Previously Formed Solid Polymer Chemically Reacted With Carbohydrate Or Derivative Patents (Class 525/54.2)
  • Patent number: 10179835
    Abstract: The present invention relates to a method for producing polyether carbonate polyols, the polyether carbonate polyols having electron-poor and electron-rich double bonds, said method preferably comprising the steps of (a) providing a suspending agent and/or an H-functional starter compound and a DMC catalyst, 03) adding at least one epoxide and (y) adding carbon dioxide, an epoxide that does not contain an unsaturated group, and at least two unsaturated compounds, the unsaturated compounds in method step (y) being selected from the group comprising unsaturated epoxides and unsaturated cyclic anhydrides, and one of the unsaturated compounds having an electron-rich double bond and one of the unsaturated compounds having an electron-poor double bond. The invention also relates to the crosslinking of polyether carbonate polyols, the polyether carbonate polyols having electronpoor and electron-rich double bonds, and to the crosslinked polyether carbonates obtainable therefrom.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: January 15, 2019
    Assignee: COVESTRO DEUTSCHLAND AG
    Inventors: Thomas E. Müller, Christoph Gürtler, Muhammad A. Subhani, Burkhard Köhler, Walter Leitner
  • Patent number: 9783668
    Abstract: A thermoplastic resin composition includes (A) a first rubber-modified acrylic-based graft copolymer having an average rubber particle diameter of greater than or equal to about 100 nm and less than about 200 nm, (B) a second rubber-modified acrylic-based graft copolymer having an average rubber particle diameter of greater than or equal to about 200 nm and less than or equal to about 400 nm, (C) a first vinyl-based copolymer of an aromatic vinyl monomer and a unsaturated nitrile monomer, and (D) a second vinyl-based copolymer of an alkyl (meth)acrylate monomer, an aromatic vinyl monomer, and a unsaturated nitrile monomer. A molded article can be made using the same.
    Type: Grant
    Filed: April 9, 2014
    Date of Patent: October 10, 2017
    Assignee: Lotte Advanced Materials Co., Ltd.
    Inventors: Ji-Eun Park, Ja-Yoon Kim, Kyun-Ha Ban, Chang-Min Hong
  • Patent number: 9750846
    Abstract: A bioresorbable and biocompatible compound for surgical use is composed of functionalized collagen cross-linked with a glycosaminoglycan.
    Type: Grant
    Filed: April 27, 2012
    Date of Patent: September 5, 2017
    Assignee: Sofradim Production SAS
    Inventors: Philippe Gravagna, Yves Bayon, Sebastien Ladet
  • Patent number: 9314529
    Abstract: An excellent nucleic acid delivery composition is provided which has reduced cytotoxicity and improved nucleic acid introduction efficiency and gene expression efficiency. The composition comprises: a block copolymer having an uncharged hydrophilic polymer segment and a cationic polymer segment; a cationic polymer; and a nucleic acid, wherein the mol percentage (B/H ratio) of the cationic groups of the block copolymer to the total cationic groups of the block copolymer and the cationic polymer is between 25% and 90%.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: April 19, 2016
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Takehiko Ishii, Kensuke Osada, Qixian Chen, Keiji Itaka, Satoshi Uchida
  • Patent number: 9302203
    Abstract: The chromatographic separation material is a cyclofructan or a derivative of cyclofructan covalently bonded to a cross-linked, organic polymer. The separation material works well in hydrophilic interaction liquid chromatography.
    Type: Grant
    Filed: July 27, 2012
    Date of Patent: April 5, 2016
    Assignees: MITSUBISHI CHEMICAL CORPORATION, AZYP, LLC
    Inventors: Haixiao Qiu, Daniel W. Armstrong, Mayumi Kiyono-Shimobe
  • Patent number: 9040626
    Abstract: The invention discloses novel morphology shifting micelles and amphiphilic coated metal nanofibers. Methods of using and making the same are also disclosed.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: May 26, 2015
    Assignee: The Regents of the University of California
    Inventors: Miao-Ping Chien, Nathan C. Gianneschi
  • Publication number: 20150141575
    Abstract: Disclosed is a polymer composite (polyplex) that contains nucleic acid, a cationic polymer, and an anionic polymer. The anionic polymer covers the surface of the composite comprising the cationic polymer and nucleic acid, has a negative charge at neutral pH, and can change so as to have a positive charge at mildly acidic pH.
    Type: Application
    Filed: November 17, 2014
    Publication date: May 21, 2015
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Kazunori KATAOKA, Yan LEE, Nobuhiro NISHIYAMA, Kanjiro MIYATA, Makoto OBA, Shigehiro HIKI, Mai SANJO, HyunJin KIM
  • Publication number: 20150134048
    Abstract: The present invention is directed to polymeric materials comprising biodegradable, dioxanone-based copolymers and implantable devices (e.g., drug-delivery stents) formed of such materials. The polymeric materials can also contain at least one additional biocompatible moiety, at least one non-fouling moiety, at least one biobeneficial material, at least one bioactive agent, or a combination thereof. The polymeric materials are designed to improve the mechanical, physical and biological properties of implantable devices formed thereof.
    Type: Application
    Filed: January 22, 2015
    Publication date: May 14, 2015
    Inventor: Ni Ding
  • Publication number: 20150133584
    Abstract: The present invention provides compositions and methods involving the use of a carboxylate graft polymer having high molecular weight and low ratio of acid-to-polyoxyalkylene groups. Such clay-mitigation is particularly useful for treating clay and clay-bearing aggregates, particularly those aggregates used for construction purposes. The present invention minimizes the need to wash the aggregates, thus preserving fine aggregates (“fines”) content in construction materials, and thereby beneficiating the performance and/or properties of construction materials containing the clay-bearing aggregates.
    Type: Application
    Filed: May 3, 2013
    Publication date: May 14, 2015
    Inventors: Lawrence Kuo, Nathan Tregger, Ho Lee, O-il Kwon
  • Publication number: 20150132399
    Abstract: A nanoformulation that includes nanoparticles. Each nanoparticle includes a shell in which a glycosaminoglycan (GAG is encapsulated. The GAG is ionically or covalently bonded to the shell. The GAG is selected from the group consisting of sulfated non-anticoagulant heparin (SNACH), super-sulfated non-anticoagulant heparin (S-SNACH), and a combination thereof. The shell includes Poly (lactic-co-glycolic acid) (PLGA), Polyethylene Glycol (PEG)-PLGA, maleimide-PEG-PLGA, chitosan, chitosan-PLGA, methoxy-polyethyleneglycol-poly (lactide-co-glycolide) (MPEG-PLGA)-(maleimide-PEG-PLGA), PLGA-Polycaprolate, or calcium alginate. A method of using the nanoformulation to treat a cancer in a subject includes administering to the patient a therapeutically effective amount of the nanoformulation for treating the cancer.
    Type: Application
    Filed: October 29, 2014
    Publication date: May 14, 2015
    Inventor: Shaker A. Mousa
  • Patent number: 9029473
    Abstract: Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.
    Type: Grant
    Filed: October 23, 2007
    Date of Patent: May 12, 2015
    Assignee: University of Strathclyde
    Inventors: Peter Cormack, Duncan Graham, Aaron Hernandez-Santana, Arun Prasath Ramaswamy, William Ewen Smith
  • Publication number: 20150118152
    Abstract: Compositions of P4HB (poly-4-hydroxybutyrate) and copolymers thereof, have been developed for pultrusion, as well as processes to produce profiles from these compositions by pultrusion. These pultrusion processes provide profiles without causing structural damage to the surface of the profile. The profiles may be used in medical applications. These compositions include P4HB, and copolymers thereof, having intrinsic viscosities less than 3.2 dl/g but greater than 0.8 dl/g. The profile may be formed using conditions such as: pull rate of 0.1 to 100 mm/min, die temperature of up to 95° C., rod stock temperature up to 95° C., draw ratio of up to 100×, pulling force of greater than 10 MPa, and clamping pressure at least 10% higher than the pulling force. Preferably, the profile is formed by pulling the rod stock through a series of dies placed at intervals with the hole sizes decreasing in diameter by 0.1 to 10 mm.
    Type: Application
    Filed: October 30, 2014
    Publication date: April 30, 2015
    Inventors: Amit Ganatra, Bhavin Shah, Said Rizk, David P. Martin, Simon F. Williams
  • Patent number: 9018344
    Abstract: The present invention provides new materials that combine the advantages of well-defined polymeric starting materials and the convenience of surface modification by physical methods into one package and, thus, offers a general and powerful platform suitable for use in numerous applications.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: April 28, 2015
    Assignees: Hitachi Chemical Company, Ltd, Hitachi Chemical Research Center, Inc.
    Inventors: Anando Devadoss, Cuihua Xue
  • Publication number: 20150111194
    Abstract: A separation material includes a saccharide bound via a linker to a matrix for enabling the separation from a liquid of substances that selectively bind to saccharide moieties. A method for preparing the material, a method for separating from a liquid substances that selective bind to saccharides, and a device including the separation material are also disclosed.
    Type: Application
    Filed: August 7, 2012
    Publication date: April 23, 2015
    Applicant: GAMBRO LUNDIA AB
    Inventors: Martin Rempfer, Wolfgang Freudemann, Cornelia Winz, Ralf Flieg, Markus Storr, Manuela Klotz, Sandra Homeyer, Torsten Knoer
  • Publication number: 20150110732
    Abstract: The present invention is directed membrane active poly(vinyl ester) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cells in vivo. RNAi polynucleotides are conjugated to the poly(vinyl ester) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(vinyl ester) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 23, 2015
    Inventors: Darren H. Wakefield, Nicholas A. Rossi, Dan Sheik
  • Publication number: 20150104408
    Abstract: The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.
    Type: Application
    Filed: November 25, 2014
    Publication date: April 16, 2015
    Applicant: ARROWHEAD MADISON INC.
    Inventors: Darren H. Wakefield, Nicholas A. Rossi, David B. Rozema, Lauren J. Almeida, Anthony L. Perillo-Nicholas
  • Patent number: 8987377
    Abstract: The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Grant
    Filed: November 16, 2011
    Date of Patent: March 24, 2015
    Assignee: Alnylam Pharmaceuticals, Inc.
    Inventors: Stephanie E. Barrett, Marina Busuek, Steven L. Colletti, Robert M. Garbaccio, Erin N. Guidry, Robert A. Kowtoniuk, Jing Liao, Craig A. Parish, Rubina G. Parmar, Tao Pei, Kevin M. Schlosser, David M. Tellers, Sandra C. Tobias, Quang T. Truong, Jacob H. Waldman, Weimin Wang, J. Michael Williams
  • Publication number: 20150056158
    Abstract: The present invention relates to branched polymer comprising a support moiety and at least three block co-polymer chains covalently coupled to and extending from the moiety, wherein: (i) each of the at least three block co-polymer chains comprise (a) a cationic polymer block that is covalently coupled to a hydrophilic polymer block, or (b) a cationic polymer block that is covalently coupled to a hydrophobic polymer block, said hydrophobic polymer block being covalently coupled to a hydrophilic polymer block; and (ii) at least one of said covalent couplings associated with each of said block co-polymer chains is biodegradable.
    Type: Application
    Filed: February 1, 2013
    Publication date: February 26, 2015
    Inventors: Pathiraja Arachchillage Gunatillake, Tracey Michelle Hinton, San Thang, Mark Leslie Tizard
  • Publication number: 20150057339
    Abstract: The polymeric carrier for delivering nucleic acid material to a cell is provided herein. The polymeric carrier can include a dendrimer group having 2 to 8 termini, each of the termini having an arginine-grafted bioreducible polymer attached thereto. In one embodiment, only a portion of the termini can have an arginine-grafted bioreducible polymer attached thereto.
    Type: Application
    Filed: January 18, 2013
    Publication date: February 26, 2015
    Inventors: Sung Wan Kim, Hye Yeong Nam, Kihoon Nam, David A. Bull
  • Publication number: 20150056157
    Abstract: The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the range of the therapeutic effect. This invention describes an innovative drug targeting strategy for the selective delivery of the anticancer drugs to endothelial cells by means of polymer-drug conjugates modified with a carbohydrate ligand for the vascular selectins. A model chemotherapeutic drug, doxorubicin, and the E-selectin ligand, sLex, are attached to a biocompatible polymer (HPMA). The selective binding, cellular uptake, intracellular fate, and cell cytotoxicity of the polymer-bound drug are investigated in human endothelial cells.
    Type: Application
    Filed: August 19, 2014
    Publication date: February 26, 2015
    Inventors: Ayelet David, Gonen Ashkenasy, Yosi Shamay
  • Publication number: 20150051347
    Abstract: A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.
    Type: Application
    Filed: November 19, 2012
    Publication date: February 19, 2015
    Applicants: THE UNIVERSITY OF TOKYO, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY, NANOCARRIER CO., LTD.
    Inventors: Kazunori Kataoka, Takehiko Ishii, Mitsuru Naito, Akira Matsumoto, Yasuki Kato
  • Publication number: 20150050233
    Abstract: The invention provides a composition containing particulate composite of a polymer and a therapeutic agent. The composition also contains a complexing agent. The polymer interacts with the complexing agent in a host-guest or a guest-host interaction to form an inclusion complex. A therapeutic composition of the invention may be used to deliver the therapeutic agent and to treat various disorders. Both the polymer of the particulate composite and the complexing agent may be used to introduce functionality into the therapeutic composition. The invention also relates to a method of preparing a composition. The method combines a therapeutic agent, a polymer having host or guest functionality, and a complexing agent having guest or host functionality to form the therapeutic composition. The complexing agent forms an inclusion complex with the polymer. The invention also relates to a method of delivering a therapeutic agent.
    Type: Application
    Filed: March 4, 2014
    Publication date: February 19, 2015
    Applicants: CALANDO PHARMACEUTICALS, INC., CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Suzie Hwang Pun, Hector Gonzalez, Mark E. Davis, Nathalie C. Bellocq, Jianjun Cheng
  • Publication number: 20150045508
    Abstract: There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation or thrombus formation, which entity is covalently attached to said surface through a link comprising a 1,2,3-triazole.
    Type: Application
    Filed: September 19, 2014
    Publication date: February 12, 2015
    Inventors: Stefan Oscarson, Martina Lahmann, Karin Leontein, Robert Vestberg
  • Publication number: 20150045507
    Abstract: One aspect of the invention relates to a biocompatible medical product comprising at least 1% by weight of dry matter of a covalently cross-linked polymer that is obtained by reacting a nucleophilically activated polyoxazoline (NU-POX) with an electrophilic cross-linking agent other than an electrophilically activated polyoxazoline, said NU-POX comprising m nucleophilic groups; and said electrophilic cross-linking agent comprising n electrophilic groups, wherein the m nucleophilic groups are capable of reaction with the n electrophilic groups to form covalent bonds; wherein m?2, n?2 and m+n?5; and wherein the NU-POX comprises at least 30 oxazoline units in case the electrophilic cross-linking agent is an isocyanate. Also provided is a kit for producing the aforementioned biocompatible cross-linked polymer. The biocompatible cross-linked polymers according to the invention have excellent implant and/or sealing characteristics.
    Type: Application
    Filed: March 15, 2013
    Publication date: February 12, 2015
    Applicant: Bender Analytical Holding B.V.
    Inventors: Johannes Caspar Mathias Elizabeth Bender, Richard Hoogenboom, Jan Cornelis Maria Ven Hest, Harry Van Goor
  • Publication number: 20150038645
    Abstract: Biomimetic adhesive compositions can be used in various aspects of subterranean treatment operations. Methods for treating a subterranean formation can comprise: providing an adhesive composition that comprises a first polymer comprising a plurality of monomers that comprise a phenolic moiety, a biopolymer that is crosslinkable with the first polymer, a crosslinking agent, and an oxidizing agent; introducing the adhesive composition into a subterranean formation; and forming a coacervate-bound surface in the subterranean formation by crosslinking the first polymer.
    Type: Application
    Filed: October 22, 2014
    Publication date: February 5, 2015
    Applicant: Halliburton Energy Services, Inc.
    Inventors: Enrique A. Reyes, Pinmanee Boontheung, Narongsak Tonmukayakul
  • Patent number: 8944257
    Abstract: The invention provides modified polysulfones substituted in one or more of the phenyl rings by functional groups and membranes composed of the modified polysulfones. Also provided are methods for the preparation of monodispersed nanoporous polymeric membranes. The membranes are useful for reverse osmosis, nanofiltration, and ultrafiltration, particularly for purification of water.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: February 3, 2015
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Moris S. Eisen, Raphael Semiat, Natalia Vainrot
  • Patent number: 8945664
    Abstract: A biomimetic surfactant polymer modified with various crosslinking embodiments is described. The crosslinking embodiments provide a biomimetic surfactant coating that is designed to resist cracking, scratching, spalling and chemical dissolution. The crosslinking embodiments comprise the use of various hydrophilic and hydrophobic functional groups. The modified biomimetic surfactant adheres to different substrate surfaces, particularly the surfaces of medical devices.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: February 3, 2015
    Assignee: Greatbatch Ltd.
    Inventors: Jan J. Lewandowski, Yubiao Liu
  • Publication number: 20150031827
    Abstract: A polymer is provided. The polymer includes a polymer chain; and a saccharide bonded with the polymer chain. The polymer does not substantially include an organic solvent and a metal atom, and includes a residual monomer in an amount of not greater than 1,000 ppm, which is relatively small compared to the amount of residual monomer in a polymer prepared by a conventional method. The polymer is preferably used for a clathrate, a sheet, and an aqueous dispersion of the sheet.
    Type: Application
    Filed: March 6, 2014
    Publication date: January 29, 2015
    Applicant: RICHO COMPANY, LTD.
    Inventors: Chiyoshi Nozaki, Chiaki Tanaka, Taichi Nemoto
  • Publication number: 20150031833
    Abstract: A compound has Formula I: A, B, C, D, W, X, Y, and Z are independently selected from hydrogen, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, aryl, aldehyde, protected aldehyde, CH, N, O, S, null, and bond; Q is selected from aldehyde, protected aldehyde, and null, at least one of A, B, C, D, W, X, Y, Z, or Q is an aldehyde or protected aldehyde; the bonds between each of A-B, B-C, C-D, W-X, X-Y, and Y-Z are selected from single bond, double bond, triple bond, and no bond; L is a linker selected from a C1-C12 alkyl, aralkyl, and aryl, any of which is optionally substituted; one or more methylene unit (CH2) of the C1-C12 alkyl is optionally replaced by any combination of oxygen, carbonyl(C?O), and NH; and R1 and R2 are independently selected from —NR3R4, halogen, C1-C8 alkoxy, aralkoxy, alkenyloxy, alkynyloxy, and OCH2CH2CN; R3 and R4 are independently a C1-C4, straight chain or branched alkyl group.
    Type: Application
    Filed: October 10, 2014
    Publication date: January 29, 2015
    Inventors: Ryan Christopher SMITH, Randall SMITH, Xiaodong ZHAO
  • Patent number: 8940333
    Abstract: An amphiphilic block copolymer is disclosed. The amphiphilic block copolymer includes one or more hydrophilic polymers, one or more hydrophobic polymer, and one or more zwitterions. The invention also provides a nanoparticle and carrier including the amphiphilic block copolymer for delivery of water insoluble drugs, growth factors, genes, or water insoluble cosmetic substances.
    Type: Grant
    Filed: March 21, 2008
    Date of Patent: January 27, 2015
    Assignee: Industrial Technology Research Institute
    Inventors: Ming-Fa Hsieh, Hsuen-Tseng Cha'ng, Chin-Fu Chen, Yuan-Chia Chang, Pei Kan, Tsai-Yu Lin
  • Publication number: 20150024488
    Abstract: The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 22, 2015
    Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Pathiraja Arachchillage Gunatillake, Carlos Gurrero-Sanchez, Tracey Michelle Hinton, San Hoa Thang, Mark Leslie Tizard
  • Publication number: 20150023875
    Abstract: The present invention provides a drug delivery system for targeted delivery of therapeutic agent-containing particles to tissues, cells, and intracellular compartments. The invention provides targeted particles comprising a particle, one or more targeting moieties, and one or more therapeutic agents to be delivered and pharmaceutical compositions comprising inventive targeted particles. The present invention provides methods of designing, manufacturing, and using inventive targeted particles and pharmaceutical compositions thereof.
    Type: Application
    Filed: April 28, 2014
    Publication date: January 22, 2015
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Omid C. Farokhzad, Jianjun Cheng, Robert S. Langer, Benjamin A. Teply, Stephen E. Zale
  • Publication number: 20150017115
    Abstract: Polymeric conjugates of a polymeric backbone formed of a plurality of backbone units and having attached to portions of the backbone units two or more therapeutically active agents, or one or more therapeutically active agents and a NCAM targeting moiety, are disclosed. Uses of such polymeric conjugates in treating and/or monitoring cancer and/or medical conditions associated with angiogenesis are also disclosed.
    Type: Application
    Filed: March 5, 2013
    Publication date: January 15, 2015
    Inventors: Ronit Satchi-Fainaro, Ela Markovsky, Hemda Baabur-Cohen
  • Publication number: 20150005447
    Abstract: Some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives. Method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications are also disclosed.
    Type: Application
    Filed: June 26, 2014
    Publication date: January 1, 2015
    Inventors: Lorenzo Berti, Andrew A. Brown, Wayne N. George
  • Publication number: 20140377838
    Abstract: Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.
    Type: Application
    Filed: January 25, 2013
    Publication date: December 25, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Heather D. Maynard, Rock J. Mancini, Juneyoung Lee, En-Wei Lin
  • Patent number: 8911717
    Abstract: A drug delivery system for delivering a drug payload to a specific tissue or cell type is disclosed. The system includes a polymalic acid molecular scaffold which can be used for attaching a plurality of molecular modules. Molecular modules include targeting antibodies for promoting cellular uptake by a target cell, and pro-drugs for altering cellular metabolism, for example, a pro-drug that alters expression of protein kinase CK2.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: December 16, 2014
    Assignees: Cedars-Sinai Medical Center, Arrogene Nanotechnology, Inc.
    Inventors: Julia Y. Ljubimova, Keith L. Black, Eggehard Holler
  • Patent number: 8906343
    Abstract: A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.
    Type: Grant
    Filed: August 3, 2012
    Date of Patent: December 9, 2014
    Assignees: Health Research, Inc., The Research Foundation of State University of New York, Regents of the University of Michigan
    Inventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
  • Publication number: 20140357787
    Abstract: The invention relates to an aldehyde based resin composition that has an ultralow formaldehyde (ULF) emission both on curing and from the final cured product and to the use thereof as a binder or adhesive for the manufacture of mineral wool (glass fibre and stone fibre) products, non-woven materials, wooden boards, plywood, coated materials and/or impregnated material products. The invention further relates to a process for the manufacture of the resin composition, to a sizing composition for use in mineral wool applications, to a sizing composition for use in saturation or impregnation applications, and to a curable aqueous composition for use in board and wood applications, comprising the aldehyde resin composition according to the invention.
    Type: Application
    Filed: November 22, 2012
    Publication date: December 4, 2014
    Inventors: Andrew Jobber, Christoph Prock, Martin Emsenhuber
  • Patent number: 8901101
    Abstract: The present invention provides membrane lytic poly(amido amine) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: December 2, 2014
    Assignee: Sirna Therapeutics, Inc.
    Inventors: Marina Busuek, Rubina G. Parmar, Michael Steven Poslusney, Weimin Wang, J. Michael Williams
  • Publication number: 20140348777
    Abstract: The present invention relates to a biodegradable polysorbitol-based osmotically active transporter (PSOAT) and gene therapy using the same as a gene carrier. The biodegradable polysorbitol-based osmotically active transporter (PSOAT) of the present invention includes a sorbitol skeleton, which imparts an osmotic pressure to the cell membrane to improve membrane permeability, thereby exhibiting remarkably improved transfection efficiency. Further, the polysorbitol-based osmotically active transporter of the present invention exhibits high DNA binding ability, effectively protects DNA from nuclease, exhibits physicochemical properties suitable for use as a gene carrier, and has very low cytotoxicity in vitro and in vivo, thereby capable of being used as a gene carrier for gene therapy.
    Type: Application
    Filed: August 12, 2011
    Publication date: November 27, 2014
    Applicant: SNU R&DB FOUNDATION
    Inventors: Myung Haing Cho, Chong Su Cho
  • Publication number: 20140350184
    Abstract: Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Inventors: Shanger WANG, Robert S. WARD, Yuan TIAN, Xuwei JIANG, Keith MCCREA, Scott CURTIN
  • Patent number: 8877321
    Abstract: A novel sizing-adhesive composition for corrugating characterised in that it comprises at least one low molecular weight, water soluble polymer such as a maltodextrin, corrugating boards prepared therewith and methods of producing them.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: November 4, 2014
    Assignee: Cargill, Incorporated
    Inventors: Freddy Johannes Martina Andriessen, Leonard Jannusch, Peter Obradovic-Sandmann
  • Publication number: 20140322287
    Abstract: Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
    Type: Application
    Filed: April 28, 2014
    Publication date: October 30, 2014
    Inventors: Simon Onis, Fanny Burrows, Krishan Kapoor, Alan Rhodes, Ajay Luthra
  • Publication number: 20140322821
    Abstract: The present invention relates to a molecule capable of binding to adrenocorticotropic hormone (ACTH) with high affinity. The present invention also relates to use of the molecule for detection and/or purification of ACTH.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 30, 2014
    Applicant: SYSMEX CORPORATION
    Inventors: Katsunori ITOH, Hiroyuki KABATA
  • Patent number: 8871512
    Abstract: Sugar-acrylic monomers are synthesized to have a carbohydrate moiety linked to an acrylate group. The sugar-acrylic monomers may be polymerized to form polymers, adhesives, hydrogels, and the like. The sugar-acrylic monomers and polymers may be used in tissue engineering, adhesives and sealers, wound healing, and the like.
    Type: Grant
    Filed: October 27, 2010
    Date of Patent: October 28, 2014
    Assignee: Empire Technology Development LLC
    Inventors: William B. Carlson, Gregory D. Phelan, Phillip A. Sullivan
  • Patent number: 8864893
    Abstract: An aqueous binder composition is provided that includes a carbohydrate and a crosslinking agent. In exemplary embodiments, the carbohydrate-based binder composition may also include a catalyst, a coupling agent, a process aid, a crosslinking density enhancer, an extender, a moisture resistant agent, a dedusting oil, a colorant, a corrosion inhibitor, a surfactant, a pH adjuster, and combinations thereof. The carbohydrate may be natural in origin and derived from renewable resources. Additionally, the carbohydrate polymer may have a dextrose equivalent (DE) number from 2 to 20. In at least one exemplary embodiment, the carbohydrate is a water-soluble polysaccharide such as dextrin or maltodextrin and the crosslinking agent is citric acid. Advantageously, the carbohydrates have a low viscosity and cure at moderate temperatures. The environmentally friendly, formaldehyde-free binder may be used in the formation of insulation materials and non-woven chopped strand mats.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: October 21, 2014
    Assignee: Owens Corning Intellectual Capital, LLC
    Inventors: Christopher M. Hawkins, Jesus M. Hernandez-Torres, Liang Chen
  • Publication number: 20140309313
    Abstract: A polymer matrix is provided comprising an amine-containing polyampholyte covalently crosslinked with an electrophilic polymer to yield an immunocompatible polymer matrix. A hydrogel system incorporating the polymer matrix is also provided.
    Type: Application
    Filed: April 14, 2014
    Publication date: October 16, 2014
    Applicant: McMaster University
    Inventors: Harald Stover, Nicholas Burke
  • Publication number: 20140303320
    Abstract: The invention provides compositions and methods relating to self-assembly of structures of various size and shape completxity. The composition include synthetic single-stranded polymers having a backbone and pre-determined linear arrangement of monomers.
    Type: Application
    Filed: July 10, 2012
    Publication date: October 9, 2014
    Applicant: President and Fellows of Harvard College
    Inventors: Thomas E. Schaus, Peng Yin, Wei Sun, David Yu Zhang
  • Patent number: 8853325
    Abstract: The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: October 7, 2014
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Patent number: 8852747
    Abstract: The invention relates to coextrusion binders including renewable and/or biodegradable polymers having good adhesion properties: at least one renewable and/or biodegradable polymer (A) grafted with a functional monomer including at least one reactive function, the grafting ratio being <1% in weight of the grafted polymer (A); at least one non-grafted renewable and/or biodegradable polymer (B) identical to (A) or compatible with (A) optionally a softener (C); and optionally a starch-based material (D). The invention also relates to multilayered structures including the binder of the present invention, in which the layers are preferably made of renewable and/or biodegradable compounds. The multilayered structures are advantageously useful in the field of food packaging.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: October 7, 2014
    Assignee: Arkema France
    Inventors: Fabrice Chopinez, Johann Laffargue, Jeau-Laurent Pradel, Damien Rauline, Samuel Devisme