Previously Formed Solid Polymer Chemically Reacted With Carbohydrate Or Derivative Patents (Class 525/54.2)
  • Publication number: 20130302405
    Abstract: An object of the present invention is to provide a glucosamine-containing glucan, a modified product and a conjugate thereof. The glucosamine-containing glucan of the present invention is a glucosamine-containing glucan wherein the glucan has a plurality of non-reducing ends and at least one glucosamine residue is bound via an ?-1,4-bond to each of two or more non-reducing ends of the branched ?-1,4-glucan, but no glucosamine residue is present at a position other than the non-reducing ends of the branched ?-1,4-glucan, wherein the degree of polymerization of the glucan is 15 or more and 4×105 or less. The glucosamine-containing glucan of the present invention can be provided by allowing an ?-glucan phosphorylase to act on an aqueous solution comprising a branched ?-1,4-glucan and glucosamine-1-phosphate.
    Type: Application
    Filed: November 7, 2011
    Publication date: November 14, 2013
    Applicant: EZAKI GLICO CO., LTD.
    Inventors: Takeshi Takaha, Akiko Kubo, Michiyo Yanase
  • Publication number: 20130302401
    Abstract: A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation.
    Type: Application
    Filed: August 26, 2011
    Publication date: November 14, 2013
    Applicant: Massachusetts Institute of Technology
    Inventors: Minglin Ma, Wendy F. Liu, Robert S. Langer, Daniel Griffith Anderson
  • Publication number: 20130303695
    Abstract: Novel hyaluronic acid-containing biopolymers are provided which exhibit increased hydrophilicity and reduced protein adsorption. In one aspect, the biopolymer incorporates hyaluronic acid modified to include a linking agent in a molar excess sufficient to yield a degree of HA modification in a range of about 1-5. In another aspect, the biopolymer incorporates unmodified hyaluronic acid.
    Type: Application
    Filed: September 2, 2011
    Publication date: November 14, 2013
    Inventors: Heather Sheardown, Andrea Weeks, Lyndon Jones, David Morrision, Johan Alauzun
  • Patent number: 8580906
    Abstract: Provided are a polyrotaxane capable of using an aqueous solvent in a fabricating process although it has hydrophobicity, an aqueous composition having the polyrotaxane, a crosslinked body comprising the polyrotaxane, etc. The polyrotaxane comprises blocking groups located at both ends of a pseudo-polyrotaxane having cyclic molecules and a linear molecule which pierces the cavities of the cyclic molecules in a skewered manner to form a clathrate therewith so as not to detach the cyclic molecules, wherein the cyclic molecules have a group represented by Formula I, a group represented by Formula II and a group represented by Formula III. Incidentally, M represents, for example, a group derived from ring-opening polymerization of ?-caprolactone or the like, A represents a hydroxy group or the like, B represents a —COOH group or the like, and C represents A and/or B: -M-A??Formula I; -M-B??Formula II; and —C??Formula III.
    Type: Grant
    Filed: May 15, 2009
    Date of Patent: November 12, 2013
    Assignee: Advanced Softmaterials Inc.
    Inventors: Yuki Hayashi, Mariko Shibuya, Masabumi Kudoh, Masahiko Yamanaka
  • Patent number: 8575282
    Abstract: A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x?1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1)(OR1?), and/or at least one x-fold (x?1) chemoselectively incorporated phosphonamide group of general formula (Ia), NPO(R1)(OR1?). R1 and R1? is selected from the group containing glycerol, polyglycerol, PEG polymers of the general empirical formula C2nH4n+2On+1 with n?1, Cn-alkyl chains with n?1; functionalized Cn-alkyl chains with n?1, aryls, heteroaryl, silyl, lipids, fluorophores, saccharides, peptides, crown ethers, or a linker, which links the aforementioned groups. R1 and R1? can be identical to or different from one another.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: November 5, 2013
    Assignee: Freie Universitaet Berlin
    Inventors: Christian Hackenberger, Giuseppe Del Signore, Remigiusz Serwa, Ina Wilkening, Robert Vallee
  • Publication number: 20130289207
    Abstract: The present invention provides membrane lytic poly(amido amine) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Application
    Filed: December 12, 2011
    Publication date: October 31, 2013
    Inventors: Marina Busuek, Rubina G. Parmar, Michael Steven Poslusney, Weimin Wang, J. Michael Williams
  • Publication number: 20130281623
    Abstract: The present invention relates to a water-soluble polymer complex that includes a water-soluble block copolymer and a magnetic nanoparticle, wherein the water-soluble polymer complex has a nonzero net magnetic moment in the absence of an applied magnetic field at ambient temperatures. The water-soluble block copolymer is preferably a diblock or triblock copolymer and the magnetic nanoparticle is preferably a ferrimagnetic or ferromagnetic nanoparticle. The water-soluble complexes may be derivatized with reactive groups and conjugated to biomolecules. Exemplary water-soluble polymer complexes covered under the scope of the invention include PEG112-b-PAA40 modified CoFe2O4; NH2-PEG112-b-PAA40 modified CoFe2O4; PNIPAM68-b-PAA28 modified CoFe2O4; and mPEG-b-PCL-b-PAA modified CoFe2O4.
    Type: Application
    Filed: April 23, 2012
    Publication date: October 24, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Krishna M. Bajjuri, David Berman, Qiu Dai, Pierre-Olivier Jubert, Hareem T. Maune, Alshakim Nelson
  • Patent number: 8562964
    Abstract: A structured drug system that is useful for delivering a drug payload to a specific tissue or cell type is disclosed. The system is based on purified polymalic acid. This polymer isolated from natural sources is biocompatible, biodegradable and of very low toxicity. The polymer is extremely water soluble and contains a large number of free carboxyl groups which can used to attach a number of different active molecules. In the examples disclosed N-hydroxysuccinimide esters of the carboxyl groups are used to attach such molecules. The active molecules include monoclonal antibodies to promote specific cellular uptake and specific pro-drugs such as antisense nucleic acids designed to modify the cellular metabolism of a target cell. The pro-drugs are advantageously linked by a somewhat labile bond so that they will be released under specific conditions. In addition, the system contains amide-linked valine to encourage membrane disruption under lysosomal conditions.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: October 22, 2013
    Assignees: Cedars-Sinai Medical Center, Arrogene Nanotechnology, Inc.
    Inventors: Julia Y. Ljubimova, Keith Black, Eggehard Holler
  • Patent number: 8563651
    Abstract: The invention provides a method comprising the steps of providing a poly(ethylene glycol) having one terminal hydroxyl group; reacting the terminal hydroxyl group of the poly(ethylene glycol) with di(1-benzotriazolyl)carbonate to form a 1-benzotriazolylcarbonate ester of the poly(ethylene glycol); reacting the 1-benzotriazolylcarbonate ester of the poly(ethylene glycol) with an amino acid to form an amino acid derivative; and reacting the amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Grant
    Filed: October 30, 2012
    Date of Patent: October 22, 2013
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Publication number: 20130272994
    Abstract: Non-linear multiblock copolymer-drug conjugates for the treatment and prevention of diseases and disorders of the eye are provided. The polymer-drug conjugates can form nanoparticles, microparticles, and implants that are capable of effectively delivering therapeutic levels of one or more active agents for an extended period of time. Administration to the eye of an active agent in the form of a non-linear multiblock copolymer-drug conjugate produces decreased side effects when compared to administration of the active agent alone. Also provided are methods of treating intraocular neovascular diseases, such as wet age-related macular degeneration as well as diseases and disorders of the eye associated with inflammation, such as uveitis.
    Type: Application
    Filed: March 12, 2013
    Publication date: October 17, 2013
    Inventors: Jie Fu, Peter A. Campochiaro, Justin Scot Hanes
  • Patent number: 8552111
    Abstract: A composition comprises a polyvinylchloride homopolymer, a biodegradable plasticizer and either a swelling agent or a carbohydrate coupled to the polyvinylchloride homopolymer or a combination thereof. The composition may further comprise a blowing agent. A coated fabric comprises a textile substrate and a biodegradable coating at least partially coating the textile substrate, wherein the biodegradable coating degrades at least 60% after 28 days under the ASTM D584 standard. A method of making a biodegradable coating comprises providing a polymer and blending a biodegradable plasticizer with the polymer to form a blend. A method of making a coated textile comprises providing a textile and a composition comprising a polymer, a biodegradable plasticizer, and at least one other component; applying the composition to the textile; and curing the composition, thereby making a coated textile.
    Type: Grant
    Filed: January 11, 2008
    Date of Patent: October 8, 2013
    Assignee: Kittrich Corporation
    Inventors: Robert F. Weber, Michael Zagryn
  • Patent number: 8546487
    Abstract: The present invention provides an efficient delivery system for a nucleic acid, more specifically, a cationic poly(amino acid) that has a side chain having a plurality of different amine functional groups in a moiety including a cationic group and that has a hydrophobic group introduced into part of the side chain, and a polyion complex (PIC) of the poly(amino acid) and an oligo- or polynucleotide.
    Type: Grant
    Filed: February 15, 2010
    Date of Patent: October 1, 2013
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Shourong Wu, Takehiko Ishii, HyunJin Kim, Kanjiro Miyata, Nobuhiro Nishiyama
  • Publication number: 20130253135
    Abstract: The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
    Type: Application
    Filed: November 16, 2011
    Publication date: September 26, 2013
    Inventors: Stephanie E. Barrett, Marina Busuek, Steven L. Colletti, Robert M. Garbaccio, Erin N. Guidry, Robert A. Kowtoniuk, Jing Liao, Craig A. Parish, Rubina G. Parmar, Tao Pei, Kevin M. Schlosser, David M. Tellers, Sandra C. Tobias, Quang T. Truong, Jacob H. Waldman, Weimin Wang, J. Michael Williams
  • Publication number: 20130243862
    Abstract: A water-soluble photo-activatable polymer including: a photo-activatable group adapted to be activated by an irradiation source and to form a covalent bond between the water-soluble photo-activatable polymer and a matrix having at least one carbon; a reactive group adapted to covalently react with a biomaterial for subsequent delivery of the biomaterial to a cell; a hydrophilic group; and a polymer precursor. A composition including a monomolecular layer of the water-soluble photo-activatable polymer and a matrix having at least one carbon, wherein the monomolecular layer is covalently attached to the matrix by a covalent bond between the photo-activatable group and the at least one carbon. The composition further includes a biomaterial having a plurality of active groups, wherein the biomaterial is covalently attached to the monomolecular layer by covalent bonding between the active groups and reactive groups. Also provided is a method for delivery of a biomaterial to a cell.
    Type: Application
    Filed: September 7, 2012
    Publication date: September 19, 2013
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Ivan Alferiev, Ilia Fishbein, Michael Chorny, Robert J. Levy, Benjamin Yellen, Darryl Williams
  • Publication number: 20130237664
    Abstract: Provided is a slush molding material which exhibits excellent low-temperature meltability and heat resistance and which can yield a molded product having excellent tensile strength and elongation. The present invention is urethane resin particles (D1) comprising a urethane or urethane-urea resin (U1) that has residues (j) bonded thereto covalently, said residues (j) being residues derived from an at least trivalent aromatic polycarboxylic acid by removing hydroxyl groups, or urethane resin particles (D2) comprising a urethane resin composition (S2) which comprises both a urethane or urethane-urea resin (U2) and a compound (E) that has a residue (j) derived from an at least trivalent aromatic polycarboxylic acid by removing hydroxyl groups, said compound (E) being represented by general formula (1), wherein the residues (j) are linked respectively to urethane or urea groups (u) of the resin (U1) or (U2) by hydrogen bonds.
    Type: Application
    Filed: November 9, 2011
    Publication date: September 12, 2013
    Applicant: SANYO CHEMICAL INDUSTRIES, LTD.
    Inventors: Shinji Watanabe, Yasuhiro Tsudo, Masaki Inaba, Jun Takeuchi, Yuko Matsumoto
  • Patent number: 8524213
    Abstract: Disclosed are highly resilient and cohesive gels formed by the cross-linking of hyaluronan or hylan, their salts or derivatives thereof, using divinyl sulfone (DVS) as the cross-linking agent. Also disclosed are viscoelastic fluids containing alkylsulfone groups covalently attached to the backbone of the polymer, formed by the mono-functionalization of the cross-linking monomer DVS with hyaluronan and/or hylan. Mechanical properties such as values of hardness and cohesiveness are specified by the rheological properties of the gels. Also disclosed are methods for the preparation of such products. They have use in many applications as injectable and/or implantable devices and as drug delivery systems.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: September 3, 2013
    Assignee: Genzyme Corporation
    Inventors: Adelya K. Leshchiner, Paul Konowicz, Min-Yeh Grace Chang, Valentina Vasilyeva
  • Patent number: 8518388
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: August 27, 2013
    Assignee: Cerulean Pharma Inc.
    Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
  • Publication number: 20130211006
    Abstract: A method of conjugating a substrate includes exchanging a counter ion associated with a biomolecule with a lipophilic counter ion to form a biomolecule complex, dispersing the biomolecule complex in a nonaqueous solvent, and coupling the biomolecule complex to a substrate in the presence of the nonaqueous solvent.
    Type: Application
    Filed: February 8, 2013
    Publication date: August 15, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventor: LIFE TECHNOLOGIES CORPORATION
  • Publication number: 20130210675
    Abstract: Provided are compositions for controlled release of biomolecules, which comprise conjugates of polymers and biomolecules conjugated through non-covalent interactions. Also provided are methods for controlled release of biomolecules and their use in biochips.
    Type: Application
    Filed: July 13, 2011
    Publication date: August 15, 2013
    Applicant: CapitalBio Corporation
    Inventors: Su Guo, Guoqing Wang, Guohao Zhang, Can Wang, Bei Han, Miao Liu, Jinxiu Zhang, Tao Deng, Wanli Xing, Jing Cheng
  • Patent number: 8501308
    Abstract: Thermoplastic polymer compositions, films, continues, closures, laminates can comprise a modified vinyl polymer said modified polymer having a moiety comprising a cyclodextrin compound. The cyclodextrin compound, locked into the polymer structure, can absorb impurities, permeants, or other undesirable volatile materials. The cooperation between the cyclodextrin grafted onto the thermoplastic polymer and the polymer structure can provide barrier properties to a film, web or other polymer structure. A permeant or a contaminant can be complexed or trapped within the polymer and held within the film or Web preventing the permeant or contaminant from passing into the interior of a container or enclosure.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: August 6, 2013
    Assignee: Cellresin Technologies, LLC
    Inventors: Willard E. Wood, Neil J. Beaverson, Kasyap V. Seethamraju
  • Publication number: 20130197160
    Abstract: A new copolymer synthesized from a glycosaminoglycan (GAG) such as hyaluronan/hyaluronic acid (HA), chondroitin sulfates, derma tan sulfates, keratan sulfates, heparan sulfate, and heparin, and an anhydride functionalized hydrophobic polymer, i.e., any polyolefin which has been ‘functionalized’ (grafted onto the backbone or incorporated into the backbone) with anhydride functional groups, such as maleic anhydride-graft-polyethylene, (or, maleated polyethylene), maleic anhydride-graft-polystyrene, maleic anhydride-graft-polypropylene, etc. The functionalized polyolefin may be a polyolefin backbone to which the anhydride functional groups have been grafted, or otherwise incorporated with the backbone. Also, a unique synthesis technique combines a modified GAG with a graft polyolefin, resulting in a unique copolymer with its constituents by-and-large covalently bound to each other.
    Type: Application
    Filed: April 18, 2008
    Publication date: August 1, 2013
    Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (CSURF)
    Inventors: Susan P. James, Rachael Kurkowski Oldinski
  • Publication number: 20130195758
    Abstract: A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer.
    Type: Application
    Filed: August 3, 2012
    Publication date: August 1, 2013
    Applicants: HEALTH RESEARCH, INC., Regents of the University of Michigan, The Research Foundation of State University of New York
    Inventors: Ravindra K. Pandey, Raoul Kopelman, Anurag Gupta, Munawwar Sajjad
  • Publication number: 20130177523
    Abstract: Described herein are gold particles that can be used to reduce tumor proliferation and treat cancer. In certain aspects, the gold particles can be modified in order to enhance selectivity and uptake of the particles by cancer cells. In certain aspects, the modified gold particles have a targeting group attached to the particle via a linker. The gold particles described herein can be used in combination with other anti-cancer agents in order to enhance overall cancer treatment. Methods for making and using the gold particles are also described herein.
    Type: Application
    Filed: July 13, 2011
    Publication date: July 11, 2013
    Applicant: University of Utah Research Foundation
    Inventors: Hamid Ghandehari, Adam Gormley, Abhijit Ray, Nate Larson
  • Publication number: 20130177978
    Abstract: Provided herein are immunoreactive peptides which can selectively bind Ehrlichia-specific anti-p120 or anti-p140 antibodies. Methods and kits utilizing the immunoreactive peptides are also provided. The immunoreactive peptides may be utilized, e.g., for determining whether or not a subject is infected with Ehrlichia chaffeensis or Ehrlichia canis. In certain embodiments, the immunoreactive peptides may be utilized in an ELISA or lateral flow assay.
    Type: Application
    Filed: December 10, 2012
    Publication date: July 11, 2013
    Applicant: RESEARCH DEVELOPMENT FOUNDATION
    Inventor: Research Development Foundation
  • Publication number: 20130172985
    Abstract: Described herein are modified gelatins or the pharmaceutically-acceptable salts or esters thereof comprising at least one actinically crosslinkable group covalently bonded to gelatin. The modified gelatins are useful in producing composites that ultimately can be used to produce three-dimensional engineered biological constructs. The composites are the polymerization product between the modified gelatin and at least one actinically crosslinkable macromolecule. Methods for making the modified gelatins are also described herein.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 4, 2013
    Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Glenn D. Prestwich, Aleksander Skardal, Jianxing Zhang
  • Patent number: 8475781
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: July 2, 2013
    Assignee: Cerulean Pharma Inc.
    Inventors: Jianjun Cheng, Mark Davis, Kay T. Khin
  • Publication number: 20130149538
    Abstract: A process for producing carrier polymer particles comprising covering the surface of organic polymer particles having a particle diameter of 0.1 to 20 micrometers with a saccharide by chemically bonding the organic polymers and the saccharide.
    Type: Application
    Filed: February 8, 2013
    Publication date: June 13, 2013
    Applicant: JSR CORPORATION
    Inventor: JSR CORPORATION
  • Publication number: 20130143325
    Abstract: A method is provided for the preparation of a poly(amic acid) in which ring opening polymerization is employed to react the monomers ethylenediaminetetraacetic dianhydride and paraphenylenediamine in an aprotic solvent. The resulting poly(amic acid) composition is suitable as a biocompatible material, such as a biomedical implant, implant coating material, tissue scaffold material, controlled release drug delivery vehicle, and cellular growth substrate.
    Type: Application
    Filed: April 8, 2011
    Publication date: June 6, 2013
    Applicant: AXCELON BIOPOLYMERS CORPORATION
    Inventors: Wankei Wan, Donna Padavan
  • Publication number: 20130142734
    Abstract: Targeting of imaging probes specifically to diseased tissues such as cancer is attractive because it potentially allows the improvement of tumor detection. One of the problems associated with conventional, low molecular weight imaging probes is the limited tumor:background ratio. To circumvent this, imaging probes may be conjugated to polymeric carriers to target solid tumors by either passive accumulation of macromolecules into tumor tissues due to the “enhanced permeability and retention” effect (EPR effect) or active targeting through the incorporation of cell-specific recognition ligands that mediate binding to cancer-specific antigens. This invention describes an innovative targeting strategy for the selective delivery of diagnostic agents into solid tumors by means of polymer-NIR fluorochrome conjugates modified with targeting ligands that bind to antigens or receptors that are uniquely expressed or over-expressed on the target cells relative to normal tissues.
    Type: Application
    Filed: January 11, 2011
    Publication date: June 6, 2013
    Inventor: Ayelet David
  • Patent number: 8450415
    Abstract: It is intended to provide a crosslinked polyrotaxane formed by crosslinking polyrotaxane molecules via chemical bonds which exhibits excellent optical properties in water or in an aqueous solution of sodium chloride; a compound having this crosslinked polyrotaxane; and a process for producing the same. The above object can be achieved by a crosslinked polyrotaxane having at least two polyrotaxane molecules, wherein linear molecules are included in a skewered-like state at the opening of cyclodextrin molecules and blocking groups are provided at both ends of the linear molecules, so as to prevent the cyclodextrin molecules from leaving, and cyclodextrin molecules in at least two polyrotaxane molecules being bonded to each other via chemical bond, characterized in that hydroxyl (—OH) groups in the cyclodextrin molecules are partly substituted with non-ionic groups.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: May 28, 2013
    Assignee: The University of Tokyo
    Inventors: Kohzo Ito, Masatoshi Kidowaki, Yuzo Sakurai, Changming Zhao
  • Publication number: 20130129665
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Application
    Filed: January 11, 2013
    Publication date: May 23, 2013
    Applicant: CERULEAN PHARMA INC.
    Inventor: Cerulean Pharma Inc.
  • Patent number: 8445604
    Abstract: The present invention relates to articles made of a thermoformable resin comprising a biodegradable polymer having polybutylene succinate (PBS) via extrusion using an extruder which comprise: a biodegradable polymer having: (a) a Ts value of up to about 160° C. (e.g., in the range of from about 50° to about 150° C.); (b) a heat distortion index of up to about 150° C. (for example, up to about 120° C.); and (c) optionally, a Tm in the range of from about 70° to about 160° C. (e.g., in the range of from about 80° to about 150° C.). Thermoformed article such as a food or beverage cup, lid, cutlery item, foodservice item, molded tray, food storage container, etc provide the ability to resist deformation during higher temperature conditions that may occur during storage and distribution.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: May 21, 2013
    Assignee: International Paper Company
    Inventors: Wei Li, Richard A Tedford, Bruce J Thoman, Thomas Robert Christie
  • Patent number: 8436104
    Abstract: The application provides a method of producing a comb polymer comprising the steps of: (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerization; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond. (iii) a catalyst capable of catalysing the polymerization of the monomer; and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerization of a plurality of the monomers to produce the comb polymer. Catalysts and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: May 7, 2013
    Assignee: Warwick Effect Polymers Limited
    Inventors: David Haddleton, Francois LeColley, Lei Tao, Giuseppe Mantovani, Adrian Carmichael, Adam Peter Jarvis, Andrew Gregory Steward
  • Publication number: 20130109808
    Abstract: Polymers comprising glucosamine (GlcN) are used to make medical devices. Examples include polyGlcN and carrier molecules containing multiple GlcN residues.
    Type: Application
    Filed: September 7, 2012
    Publication date: May 2, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventor: Jennifer H. Elisseeff
  • Publication number: 20130102049
    Abstract: Novel method and reagents for generating reversibly tagged saccharides, aldehydes, carboxyl acids, or orthoacetates useful in analytical and diagnostic applications are disclosed. Saccharides are coupled at the reducing end to tagging moieties comprising a reagent selected from a ortho-diaminobenzoic(DAB)-peptide, an aldo-imidazole or N-methylated aldo-imidazole, or an ortho-phenyldiamine (OPD) or substituted OPD. The tagged saccharide further comprising detectable or functional groups coupled to the tagging moiety are provided. Kits and reagents for chromatography and mass spectrometry are disclosed.
    Type: Application
    Filed: July 12, 2012
    Publication date: April 25, 2013
    Applicant: ACADEMIA SINICA
    Inventor: Wen-Bin YANG
  • Publication number: 20130095186
    Abstract: The present invention relates to a temperature-sensitive carrier for carrying a physiologically active substance and a preparation method thereof. Specifically, the temperature-sensitive carrier according to the present invention comprises an amphiphilic biodegradable block copolymer containing polysaccharide or polysaccharide and succinic anhydride as a hydrophilic block and polylactide as a non-ionic block. A hydrophilic polymer-polylactide copolymer according to the present invention forms a stable complex with a physiologically active substance such as protein, polynucleotide and the like in vivo via ionic bonding and temperature-sensitive hydrophobic bonding. Therefore, a copolymer according to the present invention can facilitate in vivo delivery of a physiologically active substance and used as an in vivo drug delivery system.
    Type: Application
    Filed: June 29, 2011
    Publication date: April 18, 2013
    Inventors: Kun Na, Young Seok Jung
  • Publication number: 20130084543
    Abstract: The present disclosure is directed, in part, to a curable composition, a method for augmenting a structure in a patient with a resorbable biocompatible polymer, and a biodegradable, resorbable implant comprising a biocompatible copolymer. An exemplary embodiment of the curable composition comprises (a) 60 wt. % to 95 wt. % of one or more vinyl ester monomers and/or vinylcarbonate monomers, wherein said one or more vinyl ester monomers and/or vinylcarbonate monomers are respectively selected from compounds of the general formulas (I) and (II) below: wherein n, m R1 and R2 have the meaning defined herein; (b) 0.1 to 40 wt. % of one or more multifunctional thiols; and (c) 0 to 10 wt. % of a biocompatible polymerization initiator.
    Type: Application
    Filed: September 26, 2012
    Publication date: April 4, 2013
    Applicants: Technische Universitat Wien, Synthes USA, LLC
    Inventors: Synthes USA, LLC, Technische Universitat Wien
  • Publication number: 20130078210
    Abstract: The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure.
    Type: Application
    Filed: September 27, 2012
    Publication date: March 28, 2013
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: PURDUE RESEARCH FOUNDATION
  • Patent number: 8404662
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: March 26, 2013
    Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.
    Inventors: Jianjun Cheng, Mark Davis, Kay T. Khin
  • Publication number: 20130071930
    Abstract: Polyester compositions and functionalized polyester compositions are provided along with methods of making the compositions as well as methods of using the compositions, for example as a tissue engineering bioscaffold and as a drug-delivery vehicle.
    Type: Application
    Filed: January 25, 2011
    Publication date: March 21, 2013
    Applicant: University of Pittsburgh - of the Commonwealth System of Higher Education
    Inventors: Hunghao Chu, Yadong Wang, Zhengwei You
  • Patent number: 8399431
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: March 19, 2013
    Assignees: Cerulean Pharma Inc., Insert Therapeutics, Inc., Calando Pharmaceuticals, Inc.
    Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
  • Publication number: 20130052134
    Abstract: This invention belongs to the nanotechnology field, and discloses a nano drug delivery system with polyethyleneglycol-poly(lactic-co-glycolic acid)-poly-L-lysine (PEG-PLGA-PLL) polymer as the skeleton. The carrier can have the function of passive targeting through control of the carrier particle size. The polymer skeleton is modified through introducing side chains and specific targeting groups, so as to adjust and improve the carrier performance, and enable the carrier to have the function of active targeting. Such carrier material also has the functions of transporting active substances, tumor treatment and diagnosis, ultrasonic contrast, reversing or reducing drug resistance and so on.
    Type: Application
    Filed: December 28, 2010
    Publication date: February 28, 2013
    Applicant: Shanghai Cancer Institute
    Inventors: Yourong Duan, Peifeng Liu, Ying Sun, Ming Shen, Mingjie Zhu, Yanming Sun, Qi Wang, Zelai He, Liubin Qin, Hui Yu, Xiaoyu Li, Xuelian Qi, Xiaoyan Chen, Qiufen Sun, Bingwu Wang
  • Publication number: 20130052664
    Abstract: Provided are a method and kit for isolating a target cell by using particles comprising polymers having positive charge and negative charge and at least one antibody bound to polymers. The target cell in the biological sample may be efficiently isolated and detected by using a method and kit according to an exemplary embodiment.
    Type: Application
    Filed: March 7, 2011
    Publication date: February 28, 2013
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Jong-myeon Park, Jeong-gun Lee
  • Publication number: 20130045392
    Abstract: The present invention relates to a method for preparing a hydrophobized biomaterial consisting of a hydrophilic material, notably selected from vegetable fibers having hydroxyl functions, on which are grafted chains of polymers having ester functions, said method comprising a step for putting said hydrophilic material in contact with said polymers and for a transesterification reaction between said ester functions and said hydroxyl functions.
    Type: Application
    Filed: February 24, 2011
    Publication date: February 21, 2013
    Applicant: Centre National de la Recherche Scientifique (C.N.R.S)
    Inventors: Valérie Langlois, Estelle Renard, Xavier Samain
  • Publication number: 20130036558
    Abstract: Embodiments of the present disclosure provide polymer compositions, methods of making polymer compositions, structures (e.g., textile articles) having the polymer composition covalently bonded to the structure, methods of attaching the polymer to the surface of the structure, methods of decreasing the amount of microorganisms formed on a structure, and the like.
    Type: Application
    Filed: April 26, 2011
    Publication date: February 14, 2013
    Inventor: Jason J. Locklin
  • Publication number: 20130023509
    Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Application
    Filed: September 28, 2012
    Publication date: January 24, 2013
    Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.
    Inventor: ADAVANCED CARDIOVASCULAR SYSTEMS,IN
  • Publication number: 20130017167
    Abstract: Provided herein are polymers having a therapeutic agent covalently coupled to a hydrophobic block thereof, as well as micelles and therapeutic compositions thereof.
    Type: Application
    Filed: November 12, 2010
    Publication date: January 17, 2013
    Applicant: University of Washington through its Center for Commercialization
    Inventors: Sean D. Monahan, Paul H. Johnson, Charbel Diab, Priyadarsi De, Patrick S. Stayton, Allan S. Hoffman
  • Publication number: 20130011363
    Abstract: Cationic polymers hydrolyzable to zwitterionic polymers, monomers for making the cationic polymers, surfaces that include the polymers, therapeutic agent delivery systems that include the cationic polymers, methods for administering a therapeutic agent using the delivery systems, and methods for making and using the cationic polymers, monomers, surfaces, and therapeutic agent delivery systems.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: UNIVERSITY OF WASHINGTON
    Inventors: Shaoyi Jiang, Shengfu Chen, Zheng Zhang, Gang Cheng, Hong Xue, Louisa R. Carr
  • Publication number: 20130012658
    Abstract: The disclosure relates to methods of making polymer particles, said methods including the steps of: making an aqueous gel reaction mixture; forming an emulsion having dispersed aqueous phase micelles of gel reaction mixture in a continuous phase; adding an initiator oil comprising at least one polymerization initiator to the continuous phase; and performing a polymerization reaction in the micelles. Further, the initiator oil is present in a volume % relative to a volume of the aqueous gel reaction mixture of between about 1 vol % to about 20 vol %. The disclosure also relates to methods of making nucleic acid polymer particles having the same method steps and wherein the aqueous gel reaction mixture includes a nucleic acid fragment, such as a primer.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 10, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: David Light, Barnett Rosenblum
  • Patent number: 8349308
    Abstract: A polynucleotide delivery vehicle comprising a modified polymer is provided herein, the modified polymer having the following formula: in which W1, W2, W3, W4, W5, W6, Z1, Z2, Z3, Z4, Z5, Z9, R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6 are defined herein. Also disclosed are methods of delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type and methods of reducing expression of a gene in a cell or a subject in need thereof with the modified polymer.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: January 8, 2013
    Assignee: Mersana Therapeutics, Inc.
    Inventors: Aleksandr Yurkovetskiy, Mao Yin, Timothy B. Lowinger, Carolina B. Cabral, Charles E. Hammond, Cheri A. Stevenson