Previously Formed Solid Polymer Chemically Reacted With Carbohydrate Or Derivative Patents (Class 525/54.2)
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Publication number: 20140322287Abstract: Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.Type: ApplicationFiled: April 28, 2014Publication date: October 30, 2014Inventors: Simon Onis, Fanny Burrows, Krishan Kapoor, Alan Rhodes, Ajay Luthra
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Patent number: 8871512Abstract: Sugar-acrylic monomers are synthesized to have a carbohydrate moiety linked to an acrylate group. The sugar-acrylic monomers may be polymerized to form polymers, adhesives, hydrogels, and the like. The sugar-acrylic monomers and polymers may be used in tissue engineering, adhesives and sealers, wound healing, and the like.Type: GrantFiled: October 27, 2010Date of Patent: October 28, 2014Assignee: Empire Technology Development LLCInventors: William B. Carlson, Gregory D. Phelan, Phillip A. Sullivan
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Patent number: 8864893Abstract: An aqueous binder composition is provided that includes a carbohydrate and a crosslinking agent. In exemplary embodiments, the carbohydrate-based binder composition may also include a catalyst, a coupling agent, a process aid, a crosslinking density enhancer, an extender, a moisture resistant agent, a dedusting oil, a colorant, a corrosion inhibitor, a surfactant, a pH adjuster, and combinations thereof. The carbohydrate may be natural in origin and derived from renewable resources. Additionally, the carbohydrate polymer may have a dextrose equivalent (DE) number from 2 to 20. In at least one exemplary embodiment, the carbohydrate is a water-soluble polysaccharide such as dextrin or maltodextrin and the crosslinking agent is citric acid. Advantageously, the carbohydrates have a low viscosity and cure at moderate temperatures. The environmentally friendly, formaldehyde-free binder may be used in the formation of insulation materials and non-woven chopped strand mats.Type: GrantFiled: October 8, 2010Date of Patent: October 21, 2014Assignee: Owens Corning Intellectual Capital, LLCInventors: Christopher M. Hawkins, Jesus M. Hernandez-Torres, Liang Chen
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Publication number: 20140309313Abstract: A polymer matrix is provided comprising an amine-containing polyampholyte covalently crosslinked with an electrophilic polymer to yield an immunocompatible polymer matrix. A hydrogel system incorporating the polymer matrix is also provided.Type: ApplicationFiled: April 14, 2014Publication date: October 16, 2014Applicant: McMaster UniversityInventors: Harald Stover, Nicholas Burke
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Publication number: 20140303320Abstract: The invention provides compositions and methods relating to self-assembly of structures of various size and shape completxity. The composition include synthetic single-stranded polymers having a backbone and pre-determined linear arrangement of monomers.Type: ApplicationFiled: July 10, 2012Publication date: October 9, 2014Applicant: President and Fellows of Harvard CollegeInventors: Thomas E. Schaus, Peng Yin, Wei Sun, David Yu Zhang
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Patent number: 8853325Abstract: The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepared in high purity and exhibit storage stability.Type: GrantFiled: November 21, 2011Date of Patent: October 7, 2014Assignee: Nektar TherapeuticsInventor: Antoni Kozlowski
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Patent number: 8852747Abstract: The invention relates to coextrusion binders including renewable and/or biodegradable polymers having good adhesion properties: at least one renewable and/or biodegradable polymer (A) grafted with a functional monomer including at least one reactive function, the grafting ratio being <1% in weight of the grafted polymer (A); at least one non-grafted renewable and/or biodegradable polymer (B) identical to (A) or compatible with (A) optionally a softener (C); and optionally a starch-based material (D). The invention also relates to multilayered structures including the binder of the present invention, in which the layers are preferably made of renewable and/or biodegradable compounds. The multilayered structures are advantageously useful in the field of food packaging.Type: GrantFiled: May 14, 2008Date of Patent: October 7, 2014Assignee: Arkema FranceInventors: Fabrice Chopinez, Johann Laffargue, Jeau-Laurent Pradel, Damien Rauline, Samuel Devisme
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Publication number: 20140296435Abstract: This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.Type: ApplicationFiled: June 17, 2014Publication date: October 2, 2014Inventors: Chau-Hui Wang, Chia-Hung Chen, Johnson Lin, Jing-Yi Chen, Wei-Chuan Liao
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Publication number: 20140294752Abstract: A hyaluronic acid conjugates including hyaluronic acid, a disulfide bond-containing crosslinking agent, and a cationic, amphiphilic polymer; a hyaluronic acid-nucleic acid complex in which a nucleic acid is bound to the hyaluronic acid conjugate; a composition in which the hyaluronic acid-nucleic acid complexes are crosslinked with each other; a nucleic acid delivery composition including the hyaluronic acid-nucleic acid complex; and a method of nucleic acid delivery using the hyaluronic acid-nucleic acid complex.Type: ApplicationFiled: April 1, 2014Publication date: October 2, 2014Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, SAMSUNG ELECTRONICS CO., LTD.Inventors: Hyun-Ryoung KIM, Jae Hyung Park, Hong Yeol Yoon
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Patent number: 8846110Abstract: The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker.Type: GrantFiled: October 13, 2010Date of Patent: September 30, 2014Assignee: Rexahn Pharmaceuticals, Inc.Inventors: Young B. Lee, Deog J. Kim, Chang H. Ahn
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Publication number: 20140288150Abstract: The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.Type: ApplicationFiled: March 20, 2014Publication date: September 25, 2014Inventors: Zhibin Guan, Hanxiang Zeng
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Publication number: 20140256880Abstract: Hybrid dendrite copolymer compositions include a hybrid dendrite copolymer including at least one ethylenically unsaturated first monomer, at least one second ethylenically unsaturated second monomer and a naturally derived hydroxyl containing chain transfer agent as an end group. The at least one first and second ethylenically unsaturated monomers are on separate side chains of the naturally derived hydroxyl containing chain transfer agent. Methods of preparing a hybrid dendrite copolymer are also included.Type: ApplicationFiled: November 2, 2012Publication date: September 11, 2014Inventors: Klin Aloysius Rodrigues, Michael L. Standish
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Publication number: 20140242623Abstract: We disclose methods and compositions for preparation of stimuli-responsive plastics that are capable of responding to chemical and/or physical signals in their environment. In one embodiment the plastics consist of patterned mixtures of poly(phthalaldehyde) polymers in which each polymer contains a different end-capping group (also called a “trigger”), responsive to a different signal. Other embodiments use different polymers and different triggers. The plastics may be homogeneous in composition, but each polymer within the plastic is capable of responding to a different signal and depolymerizing once this signal reacts with the trigger. This process of depolymerization enables the plastic to alter its physical features non-linearly to external signals: i.e., the degree of change in physical form is much larger than the intensity of the initial signal.Type: ApplicationFiled: May 10, 2011Publication date: August 28, 2014Inventors: Scott T. Phillips, Wanji Seo, Jessica Robbins, Michael Olah, Kyle Schmid, Anthony Michael DiLauro
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Patent number: 8816002Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.Type: GrantFiled: October 21, 2013Date of Patent: August 26, 2014Assignee: Nektar TherapeuticsInventor: Antoni Kozlowski
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Patent number: 8809454Abstract: A pressure-sensitive adhesive layer of pressure-sensitive adhesive sheet is formed by using: a pressure-sensitive adhesive composition comprising (A) a polyrotaxane having a linear-chain molecule passing through opening portions of at least two cyclic molecules, the cyclic molecules having a reactive group, the polyrotaxane having blocking groups at both ends of the linear-chain molecule, and (B) a pressure-sensitive adhesive polymer having two or more functional groups capable of reacting with the reactive group; or, a pressure-sensitive adhesive composition comprising (A) a polyrotaxane having a linear-chain molecule passing through opening portions of at least two cyclic molecules, the cyclic molecules having a reactive group, the polyrotaxane having blocking groups at both ends of the linear-chain molecule, (B?) a pressure-sensitive adhesive polymer having two or more reactive groups, and (C) a compound having two or more functional groups capable of reacting with the reactive group of the polyrotaxane (AType: GrantFiled: February 21, 2007Date of Patent: August 19, 2014Assignee: Lintec CorporationInventors: Takayuki Arai, Mikihiro Kashio, Toshikazu Takata
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Patent number: 8802773Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.Type: GrantFiled: March 15, 2013Date of Patent: August 12, 2014Assignee: Arrowhead Madison Inc.Inventors: David B Rozema, David L Lewis, Darren H Wakefield, Eric A Kitas, Philipp Hadwiger, Jon A Wolff, Ingo Roehl, Peter Mohr, Torsten Hoffmann, Kerstin Jahn-Hofmann, Hans Martin Mueller, Guenther Ott, Andrei V Blokhin, Jeffrey C Carlson, Jonathan D Benson
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Publication number: 20140221418Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: ApplicationFiled: April 11, 2014Publication date: August 7, 2014Applicant: Abbott Cardiovascular Systems Inc.Inventors: Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
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Patent number: 8791086Abstract: The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.Type: GrantFiled: July 22, 2010Date of Patent: July 29, 2014Assignee: The University of TokyoInventors: Kazunori Kataoka, Shourong Wu, Nobuhiro Nishiyama, Keiji Itaka, Hiroyuki Koyama, Takuya Hashimoto, Yuichi Tei
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Publication number: 20140199349Abstract: Disclosed is a pH-sensitive hyaluronic acid derivative, comprising at least one repeat unit as shown in the following formula (I), wherein HA represents a unit comprising N-acetyl-D-glucosamine and D-glucuronic acid, q represents an integer of 2 to 10,000; A represents a biocleavable linkage comprising at least one of hydrazone, acetal, ketal and imine; M represents at least one of a hydrophobic fragment, a hydrophilic fragment, and an amphiphilic fragment, and p represents the number of [A-M] directly grafted onto each HA unit, p represents an integer of 0 to 4, and the p of each HA unit is not 0 at the same time.Type: ApplicationFiled: December 29, 2011Publication date: July 17, 2014Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Jean-Dean Yang, Ayi-Man Chou, Jui-Hsiang Chen, Hsia-Wei Liu, Shian-Jy Wang, Tse-Min Teng, Hsiang-Fa Liang, Ming-Cheng Wei, Maggie J.M. Lu
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Publication number: 20140193342Abstract: Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with disease, one can sensitively determine the site, and extent of disease within a patient.Type: ApplicationFiled: June 11, 2012Publication date: July 10, 2014Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nathan C. Gianneschi, Michael Hahn, Robert Mattrey
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Patent number: 8772443Abstract: The present invention is directed to polymeric materials including a copolymer of at least a first and second monomer that have desirable electrical and optical properties, such as a low band gap and near infrared (NIR) absorption, respectively. More specifically, the present invention is directed to polymeric materials with charge neutrality that display increased solubility in aqueous media while retaining their electrical and optical properties. The polymeric materials in accordance with the present invention can be modified with any desired functional group to tailor the polymer materials for a specific application. Also described are methods of making the polymeric materials in accordance with the present invention.Type: GrantFiled: March 28, 2011Date of Patent: July 8, 2014Assignees: Hitachi Chemical Co., Ltd., Hitachi Chemical Research CenterInventor: Cuihua Xue
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Patent number: 8759444Abstract: Disclosed are multichromophores, and methods, articles and compositions employing them. Disclosed are methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate or in an array format on a substrate. Disclosed are detection assays employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. Disclosed are biological assays in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations.Type: GrantFiled: December 24, 2012Date of Patent: June 24, 2014Assignee: The Regents of the University of CaliforniaInventors: Guillermo C. Bazan, Bin Liu
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Publication number: 20140166580Abstract: A separation material includes a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide. A method for preparing the separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material are also described. A device employs the separation material for separating from a liquid substances that selectively bind to the saccharide of the separation material.Type: ApplicationFiled: August 7, 2012Publication date: June 19, 2014Applicant: GAMBRO LUNDIA ABInventors: Martin Rempfer, Wolfgang Freudemann, Cornelia Winz, Ralf Flieg, Markus Storr, Sandra HOMEYER, Torsten KNOER
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Publication number: 20140154203Abstract: The present invention relates, in part, to a biocompatible hydrophobic-core carrier comprising a carrier, and a plurality of hydrophobic groups covalently linked to the polymeric carrier. The hydrophobic groups are capable of dissociably linking load molecules such as therapeutic agents. The hydrophobic-core carrier may also comprise protective side chains, orienting molecules, and targeting molecules.Type: ApplicationFiled: November 22, 2013Publication date: June 5, 2014Applicant: PharmaIN CorporationInventors: Gerardo M. Castillo, Elijah M. Bolotin
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Patent number: 8722754Abstract: This invention provides an economical process for extruding a PLA resin into a low density foam with a high closed cell content. Excellent quality, low density foam is produced easily and reproducibly. The PLA resin in the foam has a weight average molecular weight of at least 500,000 and an intrinsic viscosity of at least 1.4 deciliters/gram.Type: GrantFiled: April 24, 2009Date of Patent: May 13, 2014Assignee: NatureWorks LLCInventors: James Nangeroni, Jed Richard Randall
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Publication number: 20140128544Abstract: The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.Type: ApplicationFiled: January 14, 2014Publication date: May 8, 2014Applicant: W. L. Gore & Associates, Inc.Inventors: Roy Biran, Charles D. Claude, Robert L. Cleek, Paul D. Drumheller
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Publication number: 20140127267Abstract: The present invention provides for compositions and methods for a purified fungal carbohydrate-linked polymer bead platform, which can serve as an artificial fungus-like particle to measure specific patient immune responses to fungal carbohydrate antigens. A specific embodiment comprises a purified ?-1,3-glucan chemically conjugated to a polymer bead.Type: ApplicationFiled: April 9, 2012Publication date: May 8, 2014Applicant: THE GENERAL HOSPITAL CORPORATIONInventors: Jatin M. Vyas, Jenny M. Tam, Michael K. Mansour
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Patent number: 8716399Abstract: The present invention discloses a gene carrier and the preparation method thereof. Chondroitin sulfate (CS) is reacted with methacrylic anhydride (MA) to form chrondroitin sulfate-methacrylate (CSMA), which is further covalently bound with polyethylenimine (PEI) via the Michael addition to produce a CSMA-PEI gene carrier. The CSMA-PEI gene carrier can effectively reduce the cytotoxicity of PEI and enhance the transfection efficiency of PEI.Type: GrantFiled: November 18, 2011Date of Patent: May 6, 2014Assignee: Kaohsiung Medical UniversityInventors: Li-Fang Wang, Kuo-Hsun Sung, Yu-Lun Lo
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Patent number: 8703293Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.Type: GrantFiled: April 1, 2010Date of Patent: April 22, 2014Assignee: Advanced Cardiovascular Systems, Inc.Inventors: Lothar W. Kleiner, Connie S. Kwok
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Publication number: 20140106979Abstract: Polymers having orthogonal reactive groups and solid supports comprising polymers immobilized thereto are provided. The polymers find utility in any number of applications including immobilizing analyte molecules to solid supports for high throughput assays.Type: ApplicationFiled: October 11, 2013Publication date: April 17, 2014Applicant: NVS Technologies, Inc.Inventors: Aldrich N. K. Lau, Robert G. Eason
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Publication number: 20140099507Abstract: The present invention provides a method for preparing a sample characterized by binding a substance A containing a hydrazide group to a sugar chain and/or a sugar derivative via hydrazone formation between the hydrazide group of the substance A and the reducing end of the sugar chain and/or the sugar derivative thereby to enable the separation and purification of the sugar chain and/or the sugar derivative for an analytical sample from a biological sample containing the sugar chain and/or the sugar derivative by a simple operation.Type: ApplicationFiled: September 25, 2013Publication date: April 10, 2014Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDOT UNIVERSITY, SUMITOMO BAKELITE COMPANY LIMITEDInventors: Hideyuki SHIMAOKA, Shinichiro NISHIMURA, Yasuro SHINOHARA, Yoshiaki MIURA, Jun-ichi FURUKAWA
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Publication number: 20140099277Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: ApplicationFiled: December 6, 2013Publication date: April 10, 2014Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
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Publication number: 20140094568Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.Type: ApplicationFiled: August 29, 2013Publication date: April 3, 2014Applicant: Colorado State University Research FoundationInventors: Susan P. JAMES, Min ZHANG, Guy BEAUREGARD, Rachael Kurkowski OLDINSKI
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Patent number: 8680212Abstract: The present invention relates to a composite dyestuff, characterized in that it is in the form of microcapsules composed of a polymer matrix of crosslinked polyurethane, polyurea and/or polyurethane/polyurea type obtained by interfacial polycondensation, and of a pigment.Type: GrantFiled: March 21, 2007Date of Patent: March 25, 2014Assignee: L'OrealInventors: Valérie Jeanne-Rose, Ivan Rodriguez
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Patent number: 8680202Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.Type: GrantFiled: August 10, 2012Date of Patent: March 25, 2014Assignee: Cerulean Pharma Inc.Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
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HYALURONIC ACID-NUCLEIC ACID CONJUGATE AND COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE SAME
Publication number: 20140080897Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.Type: ApplicationFiled: September 16, 2013Publication date: March 20, 2014Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATIONInventors: Sei Kwang HAHN, Kitae Park, Jeonga Yang, Won Ho Kong, Min Young Lee -
Publication number: 20140079955Abstract: An additive comprising a phosphazene compound that has at least two reactive functional groups and at least one capping functional group bonded to phosphorus atoms of the phosphazene compound. One of the at least two reactive functional groups is configured to react with cellulose and the other of the at least two reactive functional groups is configured to react with a resin, such as an amine resin or a polycarboxylic acid resin. The at least one capping functional group is selected from the group consisting of a short chain ether group, an alkoxy group, and an aryloxy group. Also disclosed are an additive-resin admixture, a method of treating a wood product, and a wood product.Type: ApplicationFiled: November 20, 2013Publication date: March 20, 2014Applicant: Battelle Energy Alliance, LLCInventors: Mason K. Harrup, Harry W. Rollins
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Publication number: 20140080215Abstract: A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n? greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n?+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L? is a divalent radical comprising 3 to 30 carbons, and q/(n?+q)×100% equals about 9% to about 47%.Type: ApplicationFiled: September 13, 2012Publication date: March 20, 2014Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Wei Cheng, Daniel J. Coady, Amanda C. Engler, James L. Hedrick, Pei Yun Teo, Chuan Yang, Yi Yan Yang
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Publication number: 20140073738Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.Type: ApplicationFiled: November 18, 2013Publication date: March 13, 2014Applicants: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATIONInventors: Geir FONNUM, Grete I. MODAHL, Nini H. KJUS, Astrid E. MOLTEBERG, Diem TRAN, Jo AASERUD, Talha M. GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
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Publication number: 20140072513Abstract: The present invention relates to degradable polyacetal polymers having a C(O)—(CH2CH2O)n—R5 or a saccharide attached to amine radical of the backbone of the polymer, their polymer-active agent conjugates and their preparation processes, to compositions, and hydrogels containing them, as well as their use in therapy, diagnostic imaging and cosmetics.Type: ApplicationFiled: April 3, 2012Publication date: March 13, 2014Inventor: Oscar Peña Gulin
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Patent number: 8664295Abstract: Described is a polymeric compound comprising a polyvinyl alcohol, a carbohydrate, and a polyacrylic acid, in which compound the carbohydrate is present as a cross-linking agent which cross-links chains of polyvinyl alcohol and/or chains of polyacrylic acid. The novel compound has interesting properties as an alternative to known plastics materials. It is biologically degradable, has a reduced content of fossil starting material, and exhibits hardness and flexibility properties useful for widespread applications, such as packaging material and coatings. In addition, a method for producing the polymeric compound is disclosed.Type: GrantFiled: October 28, 2005Date of Patent: March 4, 2014Assignee: Nutripol Capital SarlInventor: Mustafa Kaya
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Patent number: 8647613Abstract: The present invention has an object of providing a drug carrier capable of controlling in vivo pharmacokinetics. The present invention is directed to a drug carrier comprising a molecular assembly having a drug incorporated therein, and the above object can be achieved by a part of the amphiphilic molecules included in the molecular assembly being released from the molecular assembly by an external environmental change. The present invention utilizes a phenomenon that the hydrophilic-hydrophobic balance of the amphiphilic molecules is shifted toward hydrophilicity by an external environmental change and thus the amphiphilic molecules are freed from the molecular assembly.Type: GrantFiled: March 10, 2006Date of Patent: February 11, 2014Assignees: JCR Pharmaceuticals Co., Ltd., Waseda UniversityInventors: Shinji Takeoka, Yosuke Okamura, Hideo Kanazawa, Shuji Hisamoto, Kohei Kubota, Yosuke Obata
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Patent number: 8648144Abstract: The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production.Type: GrantFiled: February 22, 2010Date of Patent: February 11, 2014Assignees: Sofradim Production, Covidien LPInventors: Ahmad Robert Hadba, Sébastien Ladet
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Publication number: 20140017676Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).Type: ApplicationFiled: July 13, 2012Publication date: January 16, 2014Applicant: DIOMICS CORPORATIONInventor: Deirdre Morhet
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Publication number: 20140017762Abstract: Cross-linked, conjugated organic semiconducting polymer networks that combine improved solubility with improved electrical and/or optical properties in one package have been developed. New materials that combine advantages of good charge-carrier mobility organic materials and conjugated polymer networks as well as fairly good solubility in common organic solvents, into one package and thus offers a general and powerful platform suitable for use in numerous applications.Type: ApplicationFiled: March 28, 2012Publication date: January 16, 2014Applicant: Hitachi Chemical Research Center, Inc.Inventor: Cuihua Xue
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Patent number: 8629215Abstract: Thermoplastic polyolefin polymer composition, polymer chip, fiber, woven or nonwoven fabric, film, closures, laminates can comprise a polymer, a polymer and a nonvolatile polymer-compatible carboxylic acid. Thermoplastic polyolefin polymer composition can also comprise a polymer, a cyclodextrin-modified polymer and a nonvolatile polymer-compatible carboxylic acid. The carboxylic acid moiety of the polymer composition can react with basic materials in the polymer environment and reduce release of the basic material. The cyclodextrin can act to absorb or trap other contaminants or odors in the environment.Type: GrantFiled: July 11, 2012Date of Patent: January 14, 2014Assignee: Cellresin Technologies, LLCInventors: Willard E. Wood, Neil J. Beaverson
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Publication number: 20140004048Abstract: The invention relates to water-soluble nanoparticles and methods for making such nanoparticles. Specifically, the invention relates to dendrimerization to enhance the solubility of nanoparticles.Type: ApplicationFiled: June 19, 2013Publication date: January 2, 2014Inventors: Sergei A. VINOGRADOV, Tatiana V. Esipova
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Publication number: 20140004072Abstract: A method and a composition of gene therapy for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) based on polyplexes formed between linear polyethyleneimine (PEI) and DNA comprising the ?2-Adrenergic Receptor (?2AR) gene are provided.Type: ApplicationFiled: June 29, 2012Publication date: January 2, 2014Applicant: NATIONAL YANG MING UNIVERSITYInventors: Cheng-Wen Wu, Erh-Hsuan Lin, Hsiang-Yi Chang
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Publication number: 20130344159Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.Type: ApplicationFiled: March 9, 2012Publication date: December 26, 2013Applicants: OCCLUGEL, UNIVERSITE PARIS DIDEROT - PARIS 7, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
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Patent number: 8613611Abstract: The conductive polyrotaxane of the present invention contains an electron-accepting cyclic molecule in each of its repeating unit. Since the electron-accepting cyclic molecule remains stable because of molecular interaction with a ?-conjugated oligomer molecule, the electron-accepting cyclic molecule is not dissociated during rotaxane polymerization reaction, and thus a conductive polyrotaxane of stable quality can be obtained.Type: GrantFiled: April 22, 2010Date of Patent: December 24, 2013Assignee: National Institute for Materials ScienceInventors: Taichi Ikeda, Masayoshi Higuchi, Dirk G. Kurth