Previously Formed Solid Polymer Chemically Reacted With Carbohydrate Or Derivative Patents (Class 525/54.2)
  • Publication number: 20140296435
    Abstract: This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: Chau-Hui Wang, Chia-Hung Chen, Johnson Lin, Jing-Yi Chen, Wei-Chuan Liao
  • Publication number: 20140294752
    Abstract: A hyaluronic acid conjugates including hyaluronic acid, a disulfide bond-containing crosslinking agent, and a cationic, amphiphilic polymer; a hyaluronic acid-nucleic acid complex in which a nucleic acid is bound to the hyaluronic acid conjugate; a composition in which the hyaluronic acid-nucleic acid complexes are crosslinked with each other; a nucleic acid delivery composition including the hyaluronic acid-nucleic acid complex; and a method of nucleic acid delivery using the hyaluronic acid-nucleic acid complex.
    Type: Application
    Filed: April 1, 2014
    Publication date: October 2, 2014
    Applicants: RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY, SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Hyun-Ryoung KIM, Jae Hyung Park, Hong Yeol Yoon
  • Patent number: 8846110
    Abstract: The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker.
    Type: Grant
    Filed: October 13, 2010
    Date of Patent: September 30, 2014
    Assignee: Rexahn Pharmaceuticals, Inc.
    Inventors: Young B. Lee, Deog J. Kim, Chang H. Ahn
  • Publication number: 20140288150
    Abstract: The disclosure provides for dendronized polymers, and the use of the polymers as carriers for the intracellular delivery of nucleic acids.
    Type: Application
    Filed: March 20, 2014
    Publication date: September 25, 2014
    Inventors: Zhibin Guan, Hanxiang Zeng
  • Publication number: 20140256880
    Abstract: Hybrid dendrite copolymer compositions include a hybrid dendrite copolymer including at least one ethylenically unsaturated first monomer, at least one second ethylenically unsaturated second monomer and a naturally derived hydroxyl containing chain transfer agent as an end group. The at least one first and second ethylenically unsaturated monomers are on separate side chains of the naturally derived hydroxyl containing chain transfer agent. Methods of preparing a hybrid dendrite copolymer are also included.
    Type: Application
    Filed: November 2, 2012
    Publication date: September 11, 2014
    Inventors: Klin Aloysius Rodrigues, Michael L. Standish
  • Publication number: 20140242623
    Abstract: We disclose methods and compositions for preparation of stimuli-responsive plastics that are capable of responding to chemical and/or physical signals in their environment. In one embodiment the plastics consist of patterned mixtures of poly(phthalaldehyde) polymers in which each polymer contains a different end-capping group (also called a “trigger”), responsive to a different signal. Other embodiments use different polymers and different triggers. The plastics may be homogeneous in composition, but each polymer within the plastic is capable of responding to a different signal and depolymerizing once this signal reacts with the trigger. This process of depolymerization enables the plastic to alter its physical features non-linearly to external signals: i.e., the degree of change in physical form is much larger than the intensity of the initial signal.
    Type: Application
    Filed: May 10, 2011
    Publication date: August 28, 2014
    Inventors: Scott T. Phillips, Wanji Seo, Jessica Robbins, Michael Olah, Kyle Schmid, Anthony Michael DiLauro
  • Patent number: 8816002
    Abstract: The invention provides for preparing a polymer-active agent conjugate, the method comprising the steps of reacting an amino acid derivative with a biologically active agent under conditions to form a polymer-active agent conjugate.
    Type: Grant
    Filed: October 21, 2013
    Date of Patent: August 26, 2014
    Assignee: Nektar Therapeutics
    Inventor: Antoni Kozlowski
  • Patent number: 8809454
    Abstract: A pressure-sensitive adhesive layer of pressure-sensitive adhesive sheet is formed by using: a pressure-sensitive adhesive composition comprising (A) a polyrotaxane having a linear-chain molecule passing through opening portions of at least two cyclic molecules, the cyclic molecules having a reactive group, the polyrotaxane having blocking groups at both ends of the linear-chain molecule, and (B) a pressure-sensitive adhesive polymer having two or more functional groups capable of reacting with the reactive group; or, a pressure-sensitive adhesive composition comprising (A) a polyrotaxane having a linear-chain molecule passing through opening portions of at least two cyclic molecules, the cyclic molecules having a reactive group, the polyrotaxane having blocking groups at both ends of the linear-chain molecule, (B?) a pressure-sensitive adhesive polymer having two or more reactive groups, and (C) a compound having two or more functional groups capable of reacting with the reactive group of the polyrotaxane (A
    Type: Grant
    Filed: February 21, 2007
    Date of Patent: August 19, 2014
    Assignee: Lintec Corporation
    Inventors: Takayuki Arai, Mikihiro Kashio, Toshikazu Takata
  • Patent number: 8802773
    Abstract: The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 12, 2014
    Assignee: Arrowhead Madison Inc.
    Inventors: David B Rozema, David L Lewis, Darren H Wakefield, Eric A Kitas, Philipp Hadwiger, Jon A Wolff, Ingo Roehl, Peter Mohr, Torsten Hoffmann, Kerstin Jahn-Hofmann, Hans Martin Mueller, Guenther Ott, Andrei V Blokhin, Jeffrey C Carlson, Jonathan D Benson
  • Publication number: 20140221418
    Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
    Type: Application
    Filed: April 11, 2014
    Publication date: August 7, 2014
    Applicant: Abbott Cardiovascular Systems Inc.
    Inventors: Syed Faiyaz Ahmed Hossainy, Eugene Michal, Thierry Glauser, Connie Kwok, Stephen Dirk Pacetti
  • Patent number: 8791086
    Abstract: The present invention aims to provide a gene delivery system with higher safety and higher sustainability, which is effective for the treatment of ischemic diseases and the like, and the like. The present invention provides a pharmaceutical composition containing, as an active ingredient, a polyanionic substance that suppresses expression of PHD2, and containing a polyion complex of the polyanionic substance and a polycation chargeable polymer.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: July 29, 2014
    Assignee: The University of Tokyo
    Inventors: Kazunori Kataoka, Shourong Wu, Nobuhiro Nishiyama, Keiji Itaka, Hiroyuki Koyama, Takuya Hashimoto, Yuichi Tei
  • Publication number: 20140199349
    Abstract: Disclosed is a pH-sensitive hyaluronic acid derivative, comprising at least one repeat unit as shown in the following formula (I), wherein HA represents a unit comprising N-acetyl-D-glucosamine and D-glucuronic acid, q represents an integer of 2 to 10,000; A represents a biocleavable linkage comprising at least one of hydrazone, acetal, ketal and imine; M represents at least one of a hydrophobic fragment, a hydrophilic fragment, and an amphiphilic fragment, and p represents the number of [A-M] directly grafted onto each HA unit, p represents an integer of 0 to 4, and the p of each HA unit is not 0 at the same time.
    Type: Application
    Filed: December 29, 2011
    Publication date: July 17, 2014
    Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Jean-Dean Yang, Ayi-Man Chou, Jui-Hsiang Chen, Hsia-Wei Liu, Shian-Jy Wang, Tse-Min Teng, Hsiang-Fa Liang, Ming-Cheng Wei, Maggie J.M. Lu
  • Publication number: 20140193342
    Abstract: Provided herein is a method for enzymatically triggered assembly of polymeric nanostructures for detection of cancer-associated enzymes in vivo. By detecting enzymatic signals associated with disease, one can sensitively determine the site, and extent of disease within a patient.
    Type: Application
    Filed: June 11, 2012
    Publication date: July 10, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Nathan C. Gianneschi, Michael Hahn, Robert Mattrey
  • Patent number: 8772443
    Abstract: The present invention is directed to polymeric materials including a copolymer of at least a first and second monomer that have desirable electrical and optical properties, such as a low band gap and near infrared (NIR) absorption, respectively. More specifically, the present invention is directed to polymeric materials with charge neutrality that display increased solubility in aqueous media while retaining their electrical and optical properties. The polymeric materials in accordance with the present invention can be modified with any desired functional group to tailor the polymer materials for a specific application. Also described are methods of making the polymeric materials in accordance with the present invention.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: July 8, 2014
    Assignees: Hitachi Chemical Co., Ltd., Hitachi Chemical Research Center
    Inventor: Cuihua Xue
  • Patent number: 8759444
    Abstract: Disclosed are multichromophores, and methods, articles and compositions employing them. Disclosed are methods, articles and compositions for the detection and analysis of biomolecules in a sample. Provided assays include those determining the presence of a target biomolecule in a sample or its relative amount, or the assays may be quantitative or semi-quantitative. The methods can be performed on a substrate or in an array format on a substrate. Disclosed are detection assays employing sensor biomolecules that do not comprise a fluorophore that can exchange energy with the cationic multichromophore. Disclosed are biological assays in which energy is transferred between one or more of the multichromophore, a label on the target biomolecule, a label on the sensor biomolecule, and/or a fluorescent dye specific for a polynucleotide, in all permutations.
    Type: Grant
    Filed: December 24, 2012
    Date of Patent: June 24, 2014
    Assignee: The Regents of the University of California
    Inventors: Guillermo C. Bazan, Bin Liu
  • Publication number: 20140166580
    Abstract: A separation material includes a matrix that is bound to a saccharide, enabling the separation from a liquid of substances that selectively bind the saccharide. A method for preparing the separation material and a method for separating substances from a liquid that selectively bind a saccharide of the separation material are also described. A device employs the separation material for separating from a liquid substances that selectively bind to the saccharide of the separation material.
    Type: Application
    Filed: August 7, 2012
    Publication date: June 19, 2014
    Applicant: GAMBRO LUNDIA AB
    Inventors: Martin Rempfer, Wolfgang Freudemann, Cornelia Winz, Ralf Flieg, Markus Storr, Sandra HOMEYER, Torsten KNOER
  • Publication number: 20140154203
    Abstract: The present invention relates, in part, to a biocompatible hydrophobic-core carrier comprising a carrier, and a plurality of hydrophobic groups covalently linked to the polymeric carrier. The hydrophobic groups are capable of dissociably linking load molecules such as therapeutic agents. The hydrophobic-core carrier may also comprise protective side chains, orienting molecules, and targeting molecules.
    Type: Application
    Filed: November 22, 2013
    Publication date: June 5, 2014
    Applicant: PharmaIN Corporation
    Inventors: Gerardo M. Castillo, Elijah M. Bolotin
  • Patent number: 8722754
    Abstract: This invention provides an economical process for extruding a PLA resin into a low density foam with a high closed cell content. Excellent quality, low density foam is produced easily and reproducibly. The PLA resin in the foam has a weight average molecular weight of at least 500,000 and an intrinsic viscosity of at least 1.4 deciliters/gram.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: May 13, 2014
    Assignee: NatureWorks LLC
    Inventors: James Nangeroni, Jed Richard Randall
  • Publication number: 20140128544
    Abstract: The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a substrate via at least one heparin molecule, wherein said bound heparin entity is heparinase-1 sensitive.
    Type: Application
    Filed: January 14, 2014
    Publication date: May 8, 2014
    Applicant: W. L. Gore & Associates, Inc.
    Inventors: Roy Biran, Charles D. Claude, Robert L. Cleek, Paul D. Drumheller
  • Publication number: 20140127267
    Abstract: The present invention provides for compositions and methods for a purified fungal carbohydrate-linked polymer bead platform, which can serve as an artificial fungus-like particle to measure specific patient immune responses to fungal carbohydrate antigens. A specific embodiment comprises a purified ?-1,3-glucan chemically conjugated to a polymer bead.
    Type: Application
    Filed: April 9, 2012
    Publication date: May 8, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Jatin M. Vyas, Jenny M. Tam, Michael K. Mansour
  • Patent number: 8716399
    Abstract: The present invention discloses a gene carrier and the preparation method thereof. Chondroitin sulfate (CS) is reacted with methacrylic anhydride (MA) to form chrondroitin sulfate-methacrylate (CSMA), which is further covalently bound with polyethylenimine (PEI) via the Michael addition to produce a CSMA-PEI gene carrier. The CSMA-PEI gene carrier can effectively reduce the cytotoxicity of PEI and enhance the transfection efficiency of PEI.
    Type: Grant
    Filed: November 18, 2011
    Date of Patent: May 6, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Li-Fang Wang, Kuo-Hsun Sung, Yu-Lun Lo
  • Patent number: 8703293
    Abstract: Provided herein re a composition and a coating or a device (e.g., absorbable stent) that includes a PEGylated hyaluronic acid and a PEGylated non-hyaluronic acid biocompatible polymer and the methods of use thereof.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: April 22, 2014
    Assignee: Advanced Cardiovascular Systems, Inc.
    Inventors: Lothar W. Kleiner, Connie S. Kwok
  • Publication number: 20140106979
    Abstract: Polymers having orthogonal reactive groups and solid supports comprising polymers immobilized thereto are provided. The polymers find utility in any number of applications including immobilizing analyte molecules to solid supports for high throughput assays.
    Type: Application
    Filed: October 11, 2013
    Publication date: April 17, 2014
    Applicant: NVS Technologies, Inc.
    Inventors: Aldrich N. K. Lau, Robert G. Eason
  • Publication number: 20140099507
    Abstract: The present invention provides a method for preparing a sample characterized by binding a substance A containing a hydrazide group to a sugar chain and/or a sugar derivative via hydrazone formation between the hydrazide group of the substance A and the reducing end of the sugar chain and/or the sugar derivative thereby to enable the separation and purification of the sugar chain and/or the sugar derivative for an analytical sample from a biological sample containing the sugar chain and/or the sugar derivative by a simple operation.
    Type: Application
    Filed: September 25, 2013
    Publication date: April 10, 2014
    Applicants: NATIONAL UNIVERSITY CORPORATION HOKKAIDOT UNIVERSITY, SUMITOMO BAKELITE COMPANY LIMITED
    Inventors: Hideyuki SHIMAOKA, Shinichiro NISHIMURA, Yasuro SHINOHARA, Yoshiaki MIURA, Jun-ichi FURUKAWA
  • Publication number: 20140099277
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Application
    Filed: December 6, 2013
    Publication date: April 10, 2014
    Applicant: POLYNOVO BIOMATERIALS PTY LIMITED
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Publication number: 20140094568
    Abstract: The present disclosure provides, inter alia, a method of producing an outer layer material for forming into a structure and that comprises an entanglement having a hydrophobic polymer host and a hydrophilic guest, including in one embodiment the steps of: intermingling cloaked hydrophilic guest complexes with the hydrophobic host; crosslinking molecules of the guest with the guest; and performing a hydrolysis reaction.
    Type: Application
    Filed: August 29, 2013
    Publication date: April 3, 2014
    Applicant: Colorado State University Research Foundation
    Inventors: Susan P. JAMES, Min ZHANG, Guy BEAUREGARD, Rachael Kurkowski OLDINSKI
  • Patent number: 8680202
    Abstract: The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: March 25, 2014
    Assignee: Cerulean Pharma Inc.
    Inventors: Jianjun Cheng, Mark E. Davis, Kay T. Khin
  • Patent number: 8680212
    Abstract: The present invention relates to a composite dyestuff, characterized in that it is in the form of microcapsules composed of a polymer matrix of crosslinked polyurethane, polyurea and/or polyurethane/polyurea type obtained by interfacial polycondensation, and of a pigment.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: March 25, 2014
    Assignee: L'Oreal
    Inventors: Valérie Jeanne-Rose, Ivan Rodriguez
  • Publication number: 20140080215
    Abstract: A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n? greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n?+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L? is a divalent radical comprising 3 to 30 carbons, and q/(n?+q)×100% equals about 9% to about 47%.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 20, 2014
    Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH, INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Wei Cheng, Daniel J. Coady, Amanda C. Engler, James L. Hedrick, Pei Yun Teo, Chuan Yang, Yi Yan Yang
  • Publication number: 20140079955
    Abstract: An additive comprising a phosphazene compound that has at least two reactive functional groups and at least one capping functional group bonded to phosphorus atoms of the phosphazene compound. One of the at least two reactive functional groups is configured to react with cellulose and the other of the at least two reactive functional groups is configured to react with a resin, such as an amine resin or a polycarboxylic acid resin. The at least one capping functional group is selected from the group consisting of a short chain ether group, an alkoxy group, and an aryloxy group. Also disclosed are an additive-resin admixture, a method of treating a wood product, and a wood product.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 20, 2014
    Applicant: Battelle Energy Alliance, LLC
    Inventors: Mason K. Harrup, Harry W. Rollins
  • Publication number: 20140080897
    Abstract: The present invention relates to a hyaluronic acid-nucleic acid conjugate for the development of in vivo nucleic acid delivery system, and the development of nucleic acid delivery system using the same. Specifically, a hyaluronic acid-nucleic acid complex wherein a hyaluronic acid-alkylenediamine conjugate and nucleic acid are connected by a disulfide bond; a composition for nucleic acid delivery comprising the hyaluronic acid-nucleic acid complex as an active ingredient; a method for preparing the hyaluronic acid-nucleic acid complex; and a method for in vivo delivery of nucleic acid, comprising administering the hyaluronic acid-nucleic acid complex to a subject are provided.
    Type: Application
    Filed: September 16, 2013
    Publication date: March 20, 2014
    Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Sei Kwang HAHN, Kitae Park, Jeonga Yang, Won Ho Kong, Min Young Lee
  • Publication number: 20140073738
    Abstract: A method of forming a particle includes, in a disperse phase within an aqueous suspension, polymerizing a plurality of mer units of a hydrophilic monomer having a hydrophobic protection group, thereby forming a polymeric particle including a plurality of the hydrophobic protection groups. The method further includes converting the polymeric particle to a hydrophilic particle.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 13, 2014
    Applicants: LIFE TECHNOLOGIES AS, LIFE TECHNOLOGIES CORPORATION
    Inventors: Geir FONNUM, Grete I. MODAHL, Nini H. KJUS, Astrid E. MOLTEBERG, Diem TRAN, Jo AASERUD, Talha M. GOKMEN, Steven M. MENCHEN, Carl FULLER, Luisa ANDRUZZI, Wolfgang HINZ
  • Publication number: 20140072513
    Abstract: The present invention relates to degradable polyacetal polymers having a C(O)—(CH2CH2O)n—R5 or a saccharide attached to amine radical of the backbone of the polymer, their polymer-active agent conjugates and their preparation processes, to compositions, and hydrogels containing them, as well as their use in therapy, diagnostic imaging and cosmetics.
    Type: Application
    Filed: April 3, 2012
    Publication date: March 13, 2014
    Inventor: Oscar Peña Gulin
  • Patent number: 8664295
    Abstract: Described is a polymeric compound comprising a polyvinyl alcohol, a carbohydrate, and a polyacrylic acid, in which compound the carbohydrate is present as a cross-linking agent which cross-links chains of polyvinyl alcohol and/or chains of polyacrylic acid. The novel compound has interesting properties as an alternative to known plastics materials. It is biologically degradable, has a reduced content of fossil starting material, and exhibits hardness and flexibility properties useful for widespread applications, such as packaging material and coatings. In addition, a method for producing the polymeric compound is disclosed.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: March 4, 2014
    Assignee: Nutripol Capital Sarl
    Inventor: Mustafa Kaya
  • Patent number: 8647613
    Abstract: The present invention has an object of providing a drug carrier capable of controlling in vivo pharmacokinetics. The present invention is directed to a drug carrier comprising a molecular assembly having a drug incorporated therein, and the above object can be achieved by a part of the amphiphilic molecules included in the molecular assembly being released from the molecular assembly by an external environmental change. The present invention utilizes a phenomenon that the hydrophilic-hydrophobic balance of the amphiphilic molecules is shifted toward hydrophilicity by an external environmental change and thus the amphiphilic molecules are freed from the molecular assembly.
    Type: Grant
    Filed: March 10, 2006
    Date of Patent: February 11, 2014
    Assignees: JCR Pharmaceuticals Co., Ltd., Waseda University
    Inventors: Shinji Takeoka, Yosuke Okamura, Hideo Kanazawa, Shuji Hisamoto, Kohei Kubota, Yosuke Obata
  • Patent number: 8648144
    Abstract: The present disclosure relates to a method of forming fibers. First and second precursors, each possessing a core and at least one functional group known to have click reactivity, are mixed. The mixed precursors are then extruded under heat to cross-link during fiber production.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: February 11, 2014
    Assignees: Sofradim Production, Covidien LP
    Inventors: Ahmad Robert Hadba, Sébastien Ladet
  • Publication number: 20140017762
    Abstract: Cross-linked, conjugated organic semiconducting polymer networks that combine improved solubility with improved electrical and/or optical properties in one package have been developed. New materials that combine advantages of good charge-carrier mobility organic materials and conjugated polymer networks as well as fairly good solubility in common organic solvents, into one package and thus offers a general and powerful platform suitable for use in numerous applications.
    Type: Application
    Filed: March 28, 2012
    Publication date: January 16, 2014
    Applicant: Hitachi Chemical Research Center, Inc.
    Inventor: Cuihua Xue
  • Publication number: 20140017676
    Abstract: Collection devices and kits for biological sample collection include a biologic sample collection device having a hydrophilic swab matrix that includes a modified polycaprolactone (PCL). Methods of production and use thereof are also described herein. The biologic sample collection devices, kits and methods described herein are used to collect a biologic sample (e.g., blood, buccal cells, etc.) and to enable extraction of nucleic acids (e.g., DNA) from that biologic sample so that the nucleic acids can be analyzed (e.g., sequencing and subsequent analyses of DNA).
    Type: Application
    Filed: July 13, 2012
    Publication date: January 16, 2014
    Applicant: DIOMICS CORPORATION
    Inventor: Deirdre Morhet
  • Patent number: 8629215
    Abstract: Thermoplastic polyolefin polymer composition, polymer chip, fiber, woven or nonwoven fabric, film, closures, laminates can comprise a polymer, a polymer and a nonvolatile polymer-compatible carboxylic acid. Thermoplastic polyolefin polymer composition can also comprise a polymer, a cyclodextrin-modified polymer and a nonvolatile polymer-compatible carboxylic acid. The carboxylic acid moiety of the polymer composition can react with basic materials in the polymer environment and reduce release of the basic material. The cyclodextrin can act to absorb or trap other contaminants or odors in the environment.
    Type: Grant
    Filed: July 11, 2012
    Date of Patent: January 14, 2014
    Assignee: Cellresin Technologies, LLC
    Inventors: Willard E. Wood, Neil J. Beaverson
  • Publication number: 20140004048
    Abstract: The invention relates to water-soluble nanoparticles and methods for making such nanoparticles. Specifically, the invention relates to dendrimerization to enhance the solubility of nanoparticles.
    Type: Application
    Filed: June 19, 2013
    Publication date: January 2, 2014
    Inventors: Sergei A. VINOGRADOV, Tatiana V. Esipova
  • Publication number: 20140004072
    Abstract: A method and a composition of gene therapy for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) based on polyplexes formed between linear polyethyleneimine (PEI) and DNA comprising the ?2-Adrenergic Receptor (?2AR) gene are provided.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 2, 2014
    Applicant: NATIONAL YANG MING UNIVERSITY
    Inventors: Cheng-Wen Wu, Erh-Hsuan Lin, Hsiang-Yi Chang
  • Publication number: 20130344159
    Abstract: The present invention relates to a polymer obtained from the polymerization of: (i) at least one monomer of formula (I) (CH2?CR1)CO—K (1) wherein: K represents O—Z or NH—Z, Z representing (CR2R3)m-CH3, (CH2—CH2—O)m-H, (CH2—CH2—O)m-CH3, (CH2)m-NR4R5 with m representing an integer from 1 to 30; R1, R2, R3, R4 and R5 independently represent H or a C1-C6 alkyl; (ii) at least between 0.1 and 50% mol, advantageously between 1 and 30% mol, more advantageously between 1 and 20 mol % of a cyclic monomer having a exomethylene group of formula (II) wherein: R6, R7, R8 and R9 represent independently H or a C5-C7 aryl group or R6 and R9 are absent and R7 and R8 form together with the carbon atom on which they are bonded a C5-C7 aryl group; i and j represent independently an integer chosen between 0 and 2; X represents either O or X is not present and in this latter case, CR6R7 and CR8R9 are linked via a single bond C—C and (iii) at least one bio-resorbable block copolymer cross-linker.
    Type: Application
    Filed: March 9, 2012
    Publication date: December 26, 2013
    Applicants: OCCLUGEL, UNIVERSITE PARIS DIDEROT - PARIS 7, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Laurence Moine, Alexandre Laurent, Michel Wassef, Laurent Bedouet, Stephanie Louguet, Valentin Verret, Emeline Servais
  • Patent number: 8613611
    Abstract: The conductive polyrotaxane of the present invention contains an electron-accepting cyclic molecule in each of its repeating unit. Since the electron-accepting cyclic molecule remains stable because of molecular interaction with a ?-conjugated oligomer molecule, the electron-accepting cyclic molecule is not dissociated during rotaxane polymerization reaction, and thus a conductive polyrotaxane of stable quality can be obtained.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: December 24, 2013
    Assignee: National Institute for Materials Science
    Inventors: Taichi Ikeda, Masayoshi Higuchi, Dirk G. Kurth
  • Publication number: 20130336889
    Abstract: A nanoparticle for detecting or treating a tumor is provided. The nanoparticle includes a plurality of polymer backbones and at least one first detectable substance, of which each of the polymer backbones includes a hydrophobic region, a hydrophilic region and a chelating region, and the first detectable substance is bound to the chelating region of the polymer backbone. The hydrophobic regions of the polymer backbones form a core block, and the hydrophilic regions of the polymer backbones form a shell block surrounding the core block. A method for detecting or treating a tumor using the nanoparticle is also provided.
    Type: Application
    Filed: June 14, 2012
    Publication date: December 19, 2013
    Applicant: NATIONAL TAIWAN UNIVERSITY
    Inventors: Ming-Jium Shieh, Cheng-Liang Peng, Tsai-Yueh Luo
  • Publication number: 20130331517
    Abstract: [Problem] To provide a novel polymer derivative of a cytidine metabolic antagonist which allows release of a medicament irrespective of enzymes of the living body and is expected to have high therapeutic effects.
    Type: Application
    Filed: November 16, 2011
    Publication date: December 12, 2013
    Applicant: NIPPON KAYAKU KABUSHIKI KAISHA
    Inventors: Keiichirou Yamamoto, Manami Okazaki, Dai Kawamura
  • Patent number: 8604134
    Abstract: Vinylamine-containing polymers are disclosed where the amine groups are substituted with (1) cationic functional groups, (2) anionic functional groups, (3) hydrophobic functional groups, (4) hydrophilic functional groups, (5) functional groups that impart amphoteric characteristics to the polymers, or (6) combinations thereof. Also disclosed are processes for preparing such polymers, as well as compositions comprising such polymers. Among other applications, these polymers can be used in papermaking applications as dry strength additives, wet strength additives, retention aids, drainage aids, and pitch and stickies control agents.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: December 10, 2013
    Assignee: Hercules Incorporated
    Inventors: Qu-Ming Gu, Jonathan M. McKay, Richard J. Riehle
  • Publication number: 20130324664
    Abstract: A method capable of effectively improving a rejection of a reverse osmosis membrane without remarkably reducing a permeation flux, even if the membrane is seriously degraded. An aqueous solution containing a first organic compound having a molecular weight of less than 200, a second organic compound having a molecular weight of 200 to less than 500, and a third organic compound having a molecular weight of 500 or more is passed through the reverse osmosis membrane. The first organic compound is preferably an amino acid or an amino acid derivative. The total concentration of the first organic compound and the second organic compound and the concentration of the third organic compound are each preferably 1 to 500 mg/L.
    Type: Application
    Filed: March 5, 2012
    Publication date: December 5, 2013
    Applicant: Kurita Water Industries Ltd
    Inventors: Takahiro Kawakatsu, Tetsuya Aoki, Kunihiro Hayakawa
  • Publication number: 20130312961
    Abstract: Biomimetic adhesive compositions can be used in various aspects of subterranean treatment operations. Methods for treating a subterranean formation can comprise: providing an adhesive composition that comprises a first polymer comprising a plurality of monomers that comprise a phenolic moiety, a biopolymer that is crosslinkable with the first polymer, a crosslinking agent, and an oxidizing agent; introducing the adhesive composition into a subterranean formation; and forming a coacervate-bound surface in the subterranean formation by crosslinking the first polymer.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 28, 2013
    Applicant: Halliburton Energy Services, Inc.
    Inventors: Enrique A. Reyes, Pinmanee Boontheung, Narongsak Tonmukayakul
  • Patent number: 8586020
    Abstract: Provided are a use of chemically-crosslinkable, poly(organophosphazene)s for biomaterials, chemically-crosslinkable poly(organophosphazene)s with a physiologically active substance covalently-bonded thereto, a use thereof for biomaterials, and a process for preparing the same. The chemical crosslinkings can be made by UV irradiation, and/or a crosslinker, and/or an additive, and/or an enzyme, and/or a mixing of at least one polymer.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: November 19, 2013
    Assignee: Korea Institute of Science and Technology
    Inventors: Soo-Chang Song, Thrimoorthy Potta, Mi-Ran Park
  • Patent number: 8586372
    Abstract: The invention provides molecule-responsive gel particles which change in size in response to specific molecules and a method of production of the same. A polymer gel particle with a crosslinked structure has fixed thereto a plurality of clathrate compound-forming host molecules. Two or more of the plurality of host molecules clathrate different atomic groups in a target molecule so that the two or more host molecules and the target molecule can form a crosslink in the molecule-responsive gel particle.
    Type: Grant
    Filed: April 25, 2008
    Date of Patent: November 19, 2013
    Assignees: A School Corporation Kansai University, Japan Science and Technology Agency
    Inventors: Takashi Miyata, Tadashi Uragami