Abstract: The present disclosure relates to adenosine nitrates having cardiac activity.

Abstract: Dextrin carboxylates having about 20 to 100 anhydroglucose units of which from about 2.2 to about 3.0 average OH groups per unit are esterified through one of the carboxyls of a non-aromatic polycarboxylic acid of 2-4 carboxyls containing 2 to 10 carbon atoms, are prepared by (1) reacting the dextrin with at least about 2.8 moles of the anhydride of the polycarboxylic acid in acetic acid in the presence of a tertiary amine catalyst and (2) adding the reaction mixture to a solvent which precipitates the dextrin carboxylate and (3) isolating the so-produced dextrin carboxylate.

Abstract: Polygalactosido-sucrose Poly(H-)sulfate and salts thereof useful as complement inhibitors.

Abstract: A pharmaceutical composition containing as its active ingredient a disaccharide derivative having a derivative group of the following formula (1) bonded to a carbon atom of a disaccharide: ##STR1## wherein Y is a member of the group consisting of NH and O; and when Y is NH, Z is a member of the class consisting of --O-- (disaccharide residue) and --O--, with the proviso that one of the two bonds is attached to the other carbon atom of the same disaccharide to which the formula (1) group is bonded, and when Y is O, Z is a member of the class consisting of --NH.sub.2 and --O--, with the proviso that one of the two bonds is attached to a carbon atom of a disaccharide different from that to which the formula (1) group is bonded. The disaccharide derivative can be prepared by reacting a disaccharide with an activating agent selected from the group consisting of the cyanogen halides, organic cyanic acid esters and halogenocarbonic acid alkyl esters.

Abstract: The process for removing a secondary hydroxyl group from an organic compound having at least one secondary hydroxyl group and having any amino groups protected, comprises the reaction of a reactive ester of said secondary hydroxyl group selected from the group consisting of an O-alkylthioester and an O-alkylselenoester with at least one mole of an organotin hydride, preferably tri-n-butylstannane, in an inert, aprotic solvent at a temperature of at least about 100.degree. C and under an inert atmosphere.The process is particularly useful in removing secondary alcohols in aminoglycoside antibiotics to produce deoxy derivatives thereof having antibacterial activity.Also described are novel O-sec.-alkylthiobenzoate, O-sec.-alkyl-S-methylxanthate, N-(sec.-alkoxythiocarbonyl)-imidazole esters, and di-O-alkylthiocarbonates having at least one secondary O-alkyl group, useful intermediates of the claimed process.

Abstract: Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids having hypolipemic activity.

Abstract: Monosaccharides and disaccharides in which one or more of the hydroxy groups has been replaced by a p-vinylbenzoyloxy group are provided as new compounds. These may be copolymerized with such monomers as styrene or methyl methacrylate to provide novel copolymers.

Abstract: Amphotericin B methyl ester salts, such as salts formed by reaction with mono and dicarboxylic amino acids (such as aspartic acid, or glutamic acid or pyroglutamic acid), hydroxy carboxylic acids (such as lactic acid) and mono and dicarboxylic acids (such as acetic acid) are provided and have been found to be readily water-soluble and at least as stable and active as the parent ester compound.

Abstract: The known antibiotic daunomycin, and the novel compounds daunomycin-.beta.-anomer and 4'-epidaunomycin (both .alpha.- and .beta.-anomers) are prepared by condensing daunomycinone with reactive novel intermediates which are 1-chloro-2,3,6-trideoxy-3-trifluoroacetamido-4-trifluoroacetoxy-.alpha.-L- lyxo (or arabino) hexopyranoses.

Abstract: Derivatives of amphoteric polyene macrolide antibiotics which carry, on the lactone ring, a carboxyl group and an amino sugar characterized by a primary amine group, consist of (a) the methyl, ethyl or propyl ester formed by esterification of the carboxyl group, and (b) salts of such polyene esters constituted as acid addition salts formed with the amine group. The derivatives (a) and (b) have effective antimicrobial activity, e.g. antifungal potency, comparable to the base antibiotics, and the acid salts (b), produced by suitable acids, e.g. hydrochlorides, can be made to have good water solubility which is normally unattainable with the base compounds and is of special advantage in a compound which retains strong activity. Other addition salts are also of value, for example to provide lipid-soluble forms of these antifungal polyenes.

Abstract: A process is provided for producing amphotericin B methyl ester wherein amphotericin B is initially mixed and suspended in dimethylformamide or hexamethylphosphoric triamide for a predetermined period, and thereafter aqueous ammonia is slowly added to the mixture until a clear solution is obtained. The dissolved amphotericin B is then esterified with diazomethane in accordance with conventional procedures.

Abstract: A surface active material is prepared by reacting solid particulate sucrose with at least one alkyl ester of a fatty acid in the presence of a basic trans-esterification catalyst, at a temperature from 110.degree. to 140.degree. C, at atmospheric pressure and in the absence of any solvent. The reaction product may be purified by conversion of fatty acids and salts thereof into soaps, extracting the water-insoluble material with a ketone or ester solvent and extracting the residue with an alcohol.