Carboxylic Patents (Class 536/119)
  • Patent number: 10221120
    Abstract: The invention relates to a process for separation of organic acids from mixture of ammonium salts of one or more organic acids and other compounds via an integrated process. The process involves suspending mixture of ammonium salts of one or more organic acids and other compounds in dry hydrocarbon solvent/s or mixtures thereof; wherein the selected hydrocarbon solvent/s or mixtures thereof have boiling point more than 100° C. and forms an azeotrope with water. The reaction mixture thus obtained is dehydrated azeotropically followed by esterification of basic salt of the organic acids by addition of alcohol in presence of metal or metal salt; thereafter the individual esters formed are separated by distillation and hydrolyzed to obtain corresponding organic acids having more than 98% purity.
    Type: Grant
    Filed: May 30, 2016
    Date of Patent: March 5, 2019
    Inventor: Arvind Mallinath Lali
  • Patent number: 10028976
    Abstract: A sterile injectable aqueous formulation in the form of a gel made up of hyaluronic acid or a salt thereof and one or more polyols is provided. The gel formulation can be applied to the intra-articular area in the treatment of joint degeneration and osteoarthritis. The gel formulation has a rheology similar to that of synovial liquid and has an elevated resistance to degradation due to the synergistic action between the hyaluronic acid and the polyols.
    Type: Grant
    Filed: August 17, 2015
    Date of Patent: July 24, 2018
    Assignee: APTISSEN SA
    Inventors: Samuel Gavard Molliard, Olivier Benoit
  • Patent number: 9944860
    Abstract: Various methods are provided for treating and reacting a metathesis feedstock. In one embodiment, the method includes providing a feedstock comprising a natural oil, chemically treating the feedstock with a metal alkoxide under conditions sufficient to diminish catalyst poisons in the feedstock, and, following the treating, combining a metathesis catalyst with the feedstock under conditions sufficient to metathesize the feedstock.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: April 17, 2018
    Assignee: Elevance Renewable Sciences, Inc.
    Inventors: Steven A. Cohen, Donde R. Anderson, Zhe Wang, Timothy M. Champagne, Thay A. Ung
  • Patent number: 9730879
    Abstract: A process for the production of carbohydrate partial esters by transesterification of glycoses with fatty acid esters in the presence of emulsifiers and a catalyst mixture, to produce products with utility in the production of foods, cosmetic preparations, and in superabsorbancy applications.
    Type: Grant
    Filed: October 29, 2005
    Date of Patent: August 15, 2017
    Assignee: Cognis IP Management GmbH
    Inventors: Catherine Le Hen Ferrenbach, Marc Beuche, Myriam Roussel
  • Patent number: 9629866
    Abstract: The present invention provides the use of cordycepin or derivatives thereof in manufacture of medicaments for antidepression, said derivatives mean pharmaceutically acceptable salts, esters of crodycepin or glycosides formed by cordycepin and saccharides.
    Type: Grant
    Filed: August 12, 2013
    Date of Patent: April 25, 2017
    Assignee: BEIJING GRAGEN BIOTECHNOLOGY CO. LTD.
    Inventor: Jing Du
  • Patent number: 9579272
    Abstract: A rheology modifier which includes a mixture of short and long chain fatty acid esters is suitable for use in liquid surfactant-based compositions. A surfactant-based composition includes a surfactant, the rheology modifier, and water. The rheology modifier includes a mixture of alkyl glycoside fatty acid esters including a long chain fatty acid ester of an alkyl glycoside and a short chain fatty acid ester of an alkyl glycoside. The long chain fatty acid ester includes at least one fatty acid residue: R1(O)O—, wherein R1 is a C12 or higher hydrocarbon. The short chain fatty acid ester includes least one fatty acid residue: R2(O)O—, wherein R2 is a C6-C10 hydrocarbon.
    Type: Grant
    Filed: June 5, 2013
    Date of Patent: February 28, 2017
    Inventors: Ramiro Galleguillos, Anchuu Wu
  • Patent number: 9295276
    Abstract: Disclosed is a flavor improving agent that is a fraction derived from fruit juice or squeeze. A fraction wherein the amount of substance ratio between polyphenols and saccharides, the latter after acid hydrolysis of the fraction, (polyphenol/saccharide) is 0.1-10, and even more preferably, wherein the amount of substance ratio of the polyphenol and the saccharide before acid hydrolysis of the fraction (polyphenol/saccharide) is 1-100, and is used as a flavor improving agent. Such fraction are obtained with a method such as by a fruit juice or squeeze being absorbed onto a synthetic resin adsorbent and the adsorbed components being eluted by a solvent, or by extracting fruit juice or squeeze with ethanol. The flavor improving agent has flavor improving effects such as suppressing sourness, bitterness and astringency of foods and beverages, reducing harsh taste, contributing to a juice-like feel and contributing to a richness.
    Type: Grant
    Filed: January 13, 2014
    Date of Patent: March 29, 2016
    Assignee: Takasago International Corporation
    Inventors: Yoshikazu Toyohara, Tadahiro Hiramoto
  • Publication number: 20150126730
    Abstract: Solutions formed by combining poly(?(1?3) glucan) with concentrated aqueous formic acid solution, optionally containing methylene chloride, have been shown to produce the formylated form of the poly(?(1?3) glucan). The solutions so formed have been shown to be useful for solution spinning into fiber of poly(?(1?3) glucan) when the spun fiber is coagulated into a coagulation bath. The fibers so produced exhibit desirable physical properties. The poly(?(1?3) glucan) employed was synthesized by the action of a recombinant enzyme prepared via fermentation.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 7, 2015
    Inventor: JOHN P. O'BRIEN
  • Publication number: 20150119344
    Abstract: The invention relates to the compounds of formula I, formula II and formula III or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, formula II or formula III and methods for the treatment of cardiovascular and neurological diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.
    Type: Application
    Filed: February 16, 2013
    Publication date: April 30, 2015
    Inventor: Mahesh KANDULA
  • Patent number: 9012411
    Abstract: The invention provides novel compounds and formulations of turmeric oil, fish oil, aspirin and anti-cancer drugs (paclitaxel) having anti-inflammatory, analgesic and/or anti-cancer activity.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 21, 2015
    Assignee: Organomed Corporation
    Inventor: James N. Jacob
  • Patent number: 9011961
    Abstract: Disclosed are methods for producing esterified propoxylated glycerols and eutectic mixtures containing one or more esterified propoxylated glycerols and one or more digestible fats. Food products containing the eutectic mixtures are also disclosed.
    Type: Grant
    Filed: October 28, 2013
    Date of Patent: April 21, 2015
    Assignees: Choco Finesse LLC, Kansas State University Institute for Commercialization
    Inventors: Leopold Strecker, David Rowe, James Louis Flowers, Dana Overman
  • Patent number: 9005578
    Abstract: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
    Type: Grant
    Filed: May 28, 2013
    Date of Patent: April 14, 2015
    Assignees: Fluoropharma, Inc., The General Hospital Corporation
    Inventors: David R. Elmaleh, Timothy M. Shoup, Hongning Fu
  • Publication number: 20150057238
    Abstract: Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease.
    Type: Application
    Filed: March 13, 2013
    Publication date: February 26, 2015
    Inventors: Leticia M. Toledo-Sherman, Celia Dominguez, Michael Prime, William Leonard Mitchell, Peter Johnson, Naomi Went
  • Patent number: 8933217
    Abstract: Aspects of the invention relate to compounds, extracts and compositions thereof, and methods of using of the same, to treat neurodegenerative disorders and/or improve brain health. In certain embodiments, said compounds are pomegranate flavonoids.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: January 13, 2015
    Assignee: Amazentis SA
    Inventors: Christopher Lawrence Rinsch, Philippe Victor Leon Dupraz
  • Patent number: 8921540
    Abstract: A method for the preparation of a sucrose-6-ester is disclosed. In a first step of the method, sucrose in a polar aprotic solvent is reacted with an organotin-based acylation promoter. The water of reaction is removed at a temperature that does not exceed about 80° C. In one aspect, the water is removed by distillation of part of the polar aprotic solvent at reduced pressure. In a second step, a carboxylic acid anhydride is added. In one aspect, the resulting reaction mixture is maintained at a temperature of 10° C. or less for a period of time sufficient to produce a sucrose-6-ester. The sucrose-6-ester can be converted to sucralose.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: December 30, 2014
    Assignee: Tate & Lyle Technology Limited
    Inventors: Edward Micinski, David Coleman, James Edwin Wiley, Jr.
  • Publication number: 20140371169
    Abstract: A water soluble iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, a process for its production and a medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 18, 2014
    Inventors: Peter Geisser, Erik Philipp, Walter Richle
  • Publication number: 20140352706
    Abstract: The present invention relates to a mutant, non-naturally occurring or transgenic plant cell comprising: (i) at least one polynucleotide comprising, consisting or consisting essentially of a sequence encoding an isopropylmalate synthase and having at least 60% sequence identity to SEQ ID NO:1 or SEQ ID NO:10 or SEQ ID NO: 12 or SEQ ID NO:14; or (ii) a polypeptide encoded by said polynucleotide(s); or (iii) a polypeptide having at least 60% sequence identity to SEQ ID NO:2 or SEQ ID NO:11 or SEQ ID NO:13 or SEQ ID NO:15; or (iv) a construct, vector or expression vector comprising said polynucleotide sequence(s), optionally wherein said construct, vector or expression vector additionally comprises a promoter comprising, consisting or consisting essentially of the sequence set forth in SEQ ID NO:8 or a variant thereof with at least about 60% identity thereto or a trichome promoter.
    Type: Application
    Filed: August 31, 2012
    Publication date: December 4, 2014
    Applicant: PHILIP MORRIS PRODUCTS S.A.
    Inventors: Nicholas Bakaher, Gregor Nicholas Bindler, Michel Philippe Blanc, Simon Goepfert, Florian Martin
  • Publication number: 20140323715
    Abstract: Poly alpha-1,3-glucan ester compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing poly alpha-1,3-glucan ester compounds and films made therefrom.
    Type: Application
    Filed: June 26, 2014
    Publication date: October 30, 2014
    Inventors: RAHUL B. KASAT, Jayme L. Paullin
  • Patent number: 8841264
    Abstract: Compositions containing a combination of hydroxytyrosol and resveratrol or liqustilide or (?)-epigallocatechin gallate or honokiol or genistein or Magnolia bark extract or a combination of oleuropein and resveratrol or ligustilide are used to treat inflammatory disorders.
    Type: Grant
    Filed: July 12, 2007
    Date of Patent: September 23, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Daniel Raederstorff, Nathalie Richard, Joseph Schwager, Karin Wertz
  • Publication number: 20140243283
    Abstract: The present invention relates to compounds useful for the treatment or prevention of bacteria infections. These compounds have formula I: The invention also provides pharmaceutically acceptable compositions containing the compounds and methods of using the compositions in the treatment of bacteria infections. Finally, the invention provides processes for making compounds of the invention.
    Type: Application
    Filed: December 18, 2013
    Publication date: August 28, 2014
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Yeeman K. Ramtohul, Sanjoy Kumar Das, Caroline Cadilhac, Thumkunta Jagadeeswar Reddy, Louis Vaillancourt, Michel Gallant, Bingcan Liu, Evelyne Dietrich, Frederic Vallee, Julien Martel, Carl Poisson
  • Publication number: 20140235848
    Abstract: A method that can be used to make a precursor of L-fucose from D-glucose that includes the steps of a) making a compound of formula (1) from D-glucose, formula (1) wherein R1 is acyloxy, and Q is a group (a), (b), (c) or (d), formula (a), (b), (c) or (d) or wherein R1 is OH, and Q is a group (e), (f) or (g); formula (e), (f) or (g) wherein R2 is acyloxy and R3 is a sulphonyl leaving group; and b) producing 6-deoxy-L-talose from the compound of formula (1) formed in step a), wherein the moiety is a highly lipophilic protecting group; compounds according to formula (1), and use of a compound according to formula (1) are provided.
    Type: Application
    Filed: September 28, 2012
    Publication date: August 21, 2014
    Applicant: Glycom A/S
    Inventors: Julien BOUTET, Nikolay KHANZHIN, Filippo BONACCORSI, Gyula DEKANY
  • Publication number: 20140235814
    Abstract: The present invention relates to the use of a compound of formula (I): wherein: R represents a linear or branched alkyl group, comprising from 3 to 27 carbon atoms, said alkyl group being substituted with at least two hydroxyl groups, and which may optionally contain one or more unsaturations; and R? is selected from sugars or sugar-alcohols; for preparing polyurethanes and polyesters.
    Type: Application
    Filed: October 2, 2012
    Publication date: August 21, 2014
    Inventors: Henri Cramail, Aurélie Boyer, Cédric Epoune Lingome, Carine Alfos, Benoit Gadenne, Eric Cloutet, Yves Queneau, Sylvie Moebs
  • Publication number: 20140221642
    Abstract: Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1?, and 6? positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1?,6?-trichloro-4,1?,6?-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities.
    Type: Application
    Filed: April 4, 2014
    Publication date: August 7, 2014
    Applicant: Lexington Pharmaceuticals Laboratories, LLC
    Inventors: William Randal Erickson, Stephen Craig Fields
  • Publication number: 20140220081
    Abstract: The present invention relates to novel galactose derivatives of general formula (I) and their use as agents for stimulating the immune system of the skin and/or as immunoregulators, and for preparing a composition containing a cosmetically or pharmaceutically acceptable medium, intended in particular to prevent and/or limit the appearance of cutaneous immune imbalances, in particular related to environmental stresses.
    Type: Application
    Filed: February 18, 2014
    Publication date: August 7, 2014
    Applicant: L'OREAL
    Inventors: Nathalie PINEAU, Maria Dalko
  • Patent number: 8796446
    Abstract: A method of removing a carboxylic acid from a liquid including a tertiary amide solvent includes: forming an extraction medium including an acid-extracting tin species and an extraction solvent that is immiscible with the tertiary amide solvent; subsequently contacting the liquid with the extraction medium, forming a phase including a de-acidified tertiary amide solvent and a phase including the extraction solvent; and removing the phase including the extraction solvent, to afford a liquid including the de-acidified tertiary amide solvent. The acid-extracting tin species is one or more tin species obtained by reaction of a di(hydrocarbyl) tin oxide with less than one equivalent of a carboxylic acid, or tin species obtainable by reaction of a 1,3-diacyloxy-1,1,3,3-tetra-(hydrocarbyl)distannoxane with an aqueous base. A method of preparing a sucralose-6-acylate includes uses the foregoing method to remove a carboxylic acid from a liquid including a tertiary amide solvent and the sucralose-6-acylate.
    Type: Grant
    Filed: May 3, 2012
    Date of Patent: August 5, 2014
    Assignee: Tate & Lyle Technology Limited
    Inventors: David T. Coleman, Edward Micinski, James Edwin Wiley, Jr., Thomas A. Eilers, David A. Dentel
  • Publication number: 20140187766
    Abstract: Poly alpha-1,3-glucan ester compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing poly alpha-1,3-glucan ester compounds and films made therefrom.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 3, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Rahul B. Kasat, Jayme L. Paullin
  • Publication number: 20140187767
    Abstract: Poly alpha-1,3-glucan ester compounds are disclosed herein with a degree of substitution of about 0.05 to about 3.0. Also disclosed are methods of producing poly alpha-1,3-glucan ester compounds and films made therefrom.
    Type: Application
    Filed: December 20, 2013
    Publication date: July 3, 2014
    Applicant: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Rahul B. Kasat, Jayme L. Paullin
  • Patent number: 8741871
    Abstract: A trehalose compound having high immunopotentiating activity and low toxicity is represented by formula (1). (In the formula, X and X? each represents a phenyl, a naphthyl, R1—CHR1— (wherein R1 and R2 each represents a C7-C21 alkyl group or the like) or the like; and n and n? each independently represents an integer of 0-3). The compound exhibits a high activating effect on macrophages and neutrophils.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: June 3, 2014
    Assignee: Glytech, Inc.
    Inventors: Mugio Nishizawa, Hiroshi Imagawa, Hirofumi Yamamoto, Jun Sakurai, Masataka Oda, Reiko Nishizawa
  • Publication number: 20140142295
    Abstract: A method for producing a diester of polyhydric alcohol and fatty acid, comprising a step of reacting a monoester of polyhydric alcohol and fatty acid in the presence of a catalyst containing a hydrotalcite compound to obtain a diester of polyhydric alcohol and fatty acid.
    Type: Application
    Filed: March 21, 2012
    Publication date: May 22, 2014
    Applicant: ASAHI KASEI CHEMICALS CORPORATION
    Inventors: Kazunobu Konishi, Mayumi Sato, Makoto Okamoto
  • Publication number: 20140127709
    Abstract: A method of determining the presence or absence in a sample of a biomarker, the method comprising: (a) linking an antigen to colloidal gold to provide a gold-antigen species; (b) contacting the gold-antigen species with the sample; (c) adding a diagnosis agent to the sample; and (d) observing the colour of the sample.
    Type: Application
    Filed: May 4, 2012
    Publication date: May 8, 2014
    Applicant: Bangor University
    Inventors: Christopher David Gwenin, Mark Stephen Baird, Vanessa Valerie Gwenin, Mark Pitts
  • Patent number: 8715764
    Abstract: Disclosed are methods for producing esterified propoxylated glycerols and eutectic mixtures containing one or more esterified propoxylated glycerols and one or more digestible fats. Food products containing the eutectic mixtures are also disclosed.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: May 6, 2014
    Assignees: Choco Finesse LLC, Kansas State University Institute for Commercialization
    Inventors: Leopold Strecker, David Stewart Rowe, James Louis Flowers, Dana Overman
  • Patent number: 8691975
    Abstract: Methods for purifying and extracting compounds from a mixture are provided using a solvent-free mechanochemical method. Methods for purifying and/or extracting sugars, amino acids, and, the like, from a mixture are also provided, using a solvent-free mechanochemical method.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 8, 2014
    Assignee: Empire Technology Development LLC
    Inventor: Mark Allan Tapsak
  • Patent number: 8679569
    Abstract: Disclosed herein are compositions that include a blend of sucrose polyesters, wherein each sucrose polyester includes a sucrose moiety and a plurality of fatty acid ester moieties, wherein a percentage range of the combined fatty acid ester moieties of the sucrose polyesters in the blend have a carbon chain that has trans content.
    Type: Grant
    Filed: December 1, 2010
    Date of Patent: March 25, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Donald Benjamin Appleby, Deborah Jean Back
  • Publication number: 20140057106
    Abstract: Polysaccharide derivatives, more particularly heteropolysaccharide derivatives, especially hemicellulose derivatives, methods for making same and structures employing same are provided.
    Type: Application
    Filed: November 7, 2013
    Publication date: February 27, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Dean Van PHAN, Robert Lee BARCUS, Alyssandrea Hope HAMAD-EBRAHIMPOUR
  • Publication number: 20140039074
    Abstract: The invention generally relates to the preparation of 18F-labeled radiopharmaceuticals. In particular, this invention relates to the advanced processes for an efficient eiution of [18F]fluoride trapped in a cartridge filled with quaternary ammonium polymer which comprises inert non-basic and non-nucleophilic counter anions. The said methods and polymer cartridges allow the rapid preparation of suitable [18F]fluoride solution, which is also less basic to reduce the formation of byproducts, finally to increase radiochemical yield and purity of 18F-radiopharmaceuticals.
    Type: Application
    Filed: September 6, 2011
    Publication date: February 6, 2014
    Applicant: PIRAMAL IMAGING SA
    Inventors: Dae Yoon Chi, Byoung Se Lee, Sang Ju Lee, Jin-Sook Ryu, Seung Ju Oh
  • Publication number: 20130331353
    Abstract: A method for synthesizing variants of Tre; novel Tre variants; and a method for introducing Tre in sufficient concentration into the intracellular environment suitable to store treated mammalian cells, treat an aggregation disease, and protect treated cells from oxygen radicals are disclosed.
    Type: Application
    Filed: June 7, 2013
    Publication date: December 12, 2013
    Applicant: UNION COLLEGE
    Inventor: Margot G. Paulick
  • Publication number: 20130324712
    Abstract: Methods for purifying and extracting compounds from a mixture are provided using a solvent-free mechanochemical method. Methods for purifying and/or extracting sugars, amino acids, and, the like, from a mixture are also provided, using a solvent-free mechanochemical method.
    Type: Application
    Filed: June 4, 2012
    Publication date: December 5, 2013
    Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC
    Inventor: Mark Allan Tapsak
  • Publication number: 20130315827
    Abstract: One aspect of the present invention relates to compounds, compositions and methods for diagnosis and/or treatment of a subject suffering from an amyloidosis-associated pathological condition. In certain embodiments, the imaging and/or therapeutic agents of the instant invention may be administered to a subject for identification and/or treatment of amyloid deposits. A specific imaging method detects amyloid deposits by administering the imaging agent to the subject and detecting the spatial distribution of the agent. Differential accumulation of the agent is indicative of AD or an amyloidosis-associated pathological condition and can be monitored by using a PET or SPECT camera.
    Type: Application
    Filed: May 28, 2013
    Publication date: November 28, 2013
    Applicants: Fluoropharma, Inc., The General Hospital Corporation
    Inventors: David R. Elmaleh, Timothy M. Shoup, Hongning Fu
  • Publication number: 20130296548
    Abstract: Surface-treated carboxyalkylated polysaccharides comprising a biobased content of at least 82% are described herein. The surface-treated carboxyalkylated polysaccharides comprise a CRC of at least 18 g/g, a FSC of at least 26 g/g, and an AUL at 0.7 psi of at least 14 g/g. Processes for the manufacture of surface-treated carboxyalkylated polysaccharides are also described herein.
    Type: Application
    Filed: May 23, 2013
    Publication date: November 7, 2013
    Inventors: Danick Godin, George Koutlakis, Nicolas Nourry, Oscar Suarez-Hernandez, Andre Laforest, Isabelle Bolduc, Shoujia Dong, Caroline Lavergne
  • Publication number: 20130273082
    Abstract: The present invention relates to the use of trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups as adjuvants, to the trisaccharide derivates as such, to a method for preparing such trisaccharides, to trisaccharides obtained with such method, to adjuvant compositions comprising such trisaccharide derivates and to a vaccine or kit comprising such adjuvant compositions.
    Type: Application
    Filed: June 3, 2011
    Publication date: October 17, 2013
    Applicant: IMMUNOVO B.V.
    Inventors: Johannes Gernardus Mathias Marie Van Bree, Everardus Joannes Peter Maria Schenkelaars, Jouwert Anne Turkstra, Maria Aldegonda Jacoba Kriek, Robert Patrick Hof, Wilhelmus Martinus Maria Schaaper
  • Patent number: 8551958
    Abstract: Pro-drugs of all non-steroidal anti-inflammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L-enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: October 8, 2013
    Assignees: Stewart Italia Srl
    Inventors: Maria Grazia Rimoli, Antonio Calignano, Rosario Cuomo, Gianpiero Boatto, Enrico Abignente, Daniela Melisi, Annalisa Curcio, Elvira Luongo, Giovanna La Rana, Oscar Sasso, Giovanni Sarnelli, Roberto Russo, Maria Nieddu, Carla Cirillo, Salvatore De Lucia
  • Publication number: 20130252909
    Abstract: The invention provides a method to prevent or treat HIV-infection with synthetic tannins, and pharmaceutical compositions comprising synthetic tannins.
    Type: Application
    Filed: March 7, 2013
    Publication date: September 26, 2013
    Applicant: University of Iowa Research Foundation
    Inventors: George A. Kraus, Wendy Maury
  • Publication number: 20130245250
    Abstract: Method for producing L-fucose includes in a first aspect, a method for the preparation of L-fucose, wherein L-fucose precursors are produced from pectin and L-fucose is produced from the L-fucose precursors; in a second aspect, a method for the preparation of L-fucose from D-galacturonic acid or a salt thereof, wherein L-fucose precursors are produced from D-galacturonic acid of a salt thereof, and L-fucose is produced from the L-fucose precursors; and an L-fucose precursor as shown in Formula A, wherein R is a linear or branched chain saturated hydrocarbon group with 1-6 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, n-hexyl, etc., preferably a methyl group.
    Type: Application
    Filed: October 13, 2011
    Publication date: September 19, 2013
    Applicant: GLYCOM A/S
    Inventors: Andreas Schroven, Gyula Dekany, Christoph Röhrig, Ioannis Vrasidas, Ignacio Figueroa Pérez, Markus Hederos, Julien Boutet, Lars Kröger, Piroska Kovács-Pénzes, Ferenc Horváth, Christian Risinger, Gergely Pipa
  • Publication number: 20130203698
    Abstract: Water soluble Iron carbohydrate complex obtainable from an aqueous solution of iron(III) salt and an aqueous solution of the oxidation product of one or more maltrodextrins using an aqueous hypochlorite solution at a pH-value within the alkaline range, where, when one maltodextrin is applied, its dextrose equivalent lies between 5 and 20, and when a mixture of several maltodextrins is applied, the dextrose equivalent of the mixture lies between 5 and 20 and the dextrose equivalent of each individual maltodextrin contained in the mixture lies between 2 and 40, process for its production and medicament for the treatment and prophylaxis of iron deficiency conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 8, 2013
    Applicant: VIFOR (INTERNATIONAL) AG.
    Inventor: Vifor (International) AG.
  • Publication number: 20130197213
    Abstract: Disclosed is a method of chlorinating a carbohydrate or derivative thereof, for example, a sucrose-6-ester at the 4,1?, and 6? positions, with irreversible removal of HCl formed during the reaction to form the chlorinated carbohydrate or derivative thereof, for example, a 4,1?,6?-trichloro-4,1?,6?-trideoxy-6-O-ester of galactosucrose (TGS-6E). The irreversible removal of HCl can be carried out by an irreversible physical process and/or an irreversible chemical process. Sucralose, an artificial sweetener, can be prepared by deesterification of the TGS-6E. The chlorination reaction takes place at low temperatures and the desired chlorinated product is obtained in high yields and in high purities.
    Type: Application
    Filed: March 14, 2013
    Publication date: August 1, 2013
    Applicant: LEXINGTON PHARMACEUTICALS LABORATORIES, LLC
    Inventor: Lexington Pharmaceuticals Laboratories, LLC
  • Publication number: 20130129784
    Abstract: The invention provides methods and compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo by administration of a fucose analog.
    Type: Application
    Filed: August 5, 2011
    Publication date: May 23, 2013
    Applicant: Seattle Genetics, Inc.
    Inventors: Peter Senter, Stephen Alley, Dennis Benjamin
  • Publication number: 20130072674
    Abstract: There is provided an improved method for the recovery of residual, unseparated ?-ACF from reaction mixtures remaining from an initial synthesis of ACF, which is in particular usable on a large industrial scale, more particularly in the production of capecitabine.
    Type: Application
    Filed: November 13, 2012
    Publication date: March 21, 2013
    Applicant: Hoffmann-La Roche Inc.
    Inventor: Hoffmann-La Roche Inc.
  • Publication number: 20130029922
    Abstract: The invention provides novel compounds and formulations of turmeric oil, fish oil, aspirin and anti-cancer drugs (paclitaxel) having anti-inflammatory, analgesic and/or anti-cancer activity.
    Type: Application
    Filed: June 29, 2012
    Publication date: January 31, 2013
    Applicant: ORGANOMED CORPORATION
    Inventor: James N. Jacob
  • Publication number: 20130017308
    Abstract: A dendritic emulsifier for forming an oil-in-water emulsion includes an anhydride-modified phytoglycogen or glycogen-type material. A method of preparing an oil-in-water emulsion includes: (a) combining oil, water, and a dendritic emulsifier; and (b) mixing a combination of the oil, water, and dendritic emulsifier. A method of preparing a dendritic emulsifier includes reacting an anhydride with a phytoglycogen or glycogen-type material in solution, thereby forming an anhydride-modified phytoglycogen or glycogen-type material.
    Type: Application
    Filed: November 17, 2010
    Publication date: January 17, 2013
    Applicant: PURDUE RESEARCH FOUNDATION
    Inventor: Yuan Yao
  • Publication number: 20130011421
    Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.
    Type: Application
    Filed: September 13, 2012
    Publication date: January 10, 2013
    Applicant: Sloan-Kettering Institute for Cancer Research
    Inventors: David Gin, Michelle Adams, Kai Deng, Nicholas Perl, Annie Won, Philip Livingston, Govind Ragupathi