Carboxylic Patents (Class 536/119)
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Publication number: 20100228019Abstract: A process for producing a glucan derivative modified with a cyclic ester with a highly suppressed homopolymerization of a cyclic ester is provided. In a production process for a modified glucan derivative, by allowing a glucan derivative having a hydroxyl group to react with a cyclic ester in a solvent in the presence of a ring-opening polymerization catalyst to give a modified glucan derivative in which the cyclic ester is graft-polymerized to the glucan derivative, (1) the ring-opening polymerization catalyst is a metal complex which by itself does not initiate the polymerization of the cyclic ester; and (2) the solvent comprises a nonaromatic hydrocarbon solvent having a solubility in water of not more than 10% by weight at 20° C.Type: ApplicationFiled: January 19, 2007Publication date: September 9, 2010Applicant: DAICEL CHEMICAL INDUSTRIES, LTD., MAINICHI INTECO.Inventors: Koichi Umemoto, Hiroshi Katayama
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Patent number: 7763587Abstract: An O-acyl product derived from glucose which may be obtained by partial or total esterification of glucose and of vitamin F, comprising a mixture of esters, for example, monoesters, of glucose and of at least one acid chosen from linoleic acid, oleic acid, palmitic acid and stearic acid, compositions, for example, cosmetic and pharmaceutical compositions, comprising this novel derivative, and their use for improving the condition of head hair and/or other hairs, and, for example, for reducing and/or impeding the loss of head hair and/or other hairs, and/or for inducing and/or stimulating hair growth, as well as a process for preparing O-acyl derivatives mainly in position 6 of glucose, comprising preparing a mixed anhydride by reacting a carboxylic acid with a trimethylacetyl halide, followed by reacting said mixed anhydride formed with glucose.Type: GrantFiled: June 12, 2003Date of Patent: July 27, 2010Assignee: L'Oreal S.A.Inventors: Jean-François Michelet, Maria Dalko, Bruno Bernard, Didier Semeria, Michel Philippe
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Publication number: 20100163484Abstract: Disclosed is a method of denitrifying a solution including introducing into the solution an amount of a carbon source within a duration and at a frequency so that indigenous heterotrophic bacteria deplete dissolved oxygen in the solution and decompose oxygen from nitrate in the solution to obtain its combined oxygen. Related apparatuses and compounds also are disclosed.Type: ApplicationFiled: June 18, 2007Publication date: July 1, 2010Inventors: Murphy J. Cormier, Ronald J. Suchecki, JR., Robert K. Pertuit, Donald L. Brown, Troy L. Cormier
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Publication number: 20100160251Abstract: The present invention relates to the use of at least one lactose-derived C-glycoside of general formula (I): as an agent for protecting and/or stimulating the activity and/or the proliferation of gamma-delta T lymphocyte cells (??T cells) in a composition containing a cosmetically or pharmaceutically acceptable medium. The composition will find applications for promoting skin tissue repair, for reequilibrating epidermal proliferation and differentiation disorders which appear with lack of sleep, and for improving the appearance of the head of hair and limiting hair loss.Type: ApplicationFiled: April 5, 2007Publication date: June 24, 2010Inventor: Lionel Brenton
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Patent number: 7728124Abstract: A method for the manufacture of carboxyalkylinulin is disclosed comprising preparing an aqueous medium containing dispersed therein a halogenoalkylcarboxylate, adding to the carboxylate containing medium, under substantially neutral pH conditions, an inulin followed by heating this mixture to a temperature in the range of from 60° C. to 90° C. and proceeding with the reaction at alkaline conditions, pH 8-12, while simultaneously adding additional halogenoalkylcarboxylate and alkalihydroxide. The carboxyalkylinulin so formed is recovered in a manner known per sé.Type: GrantFiled: January 28, 2005Date of Patent: June 1, 2010Assignees: Koninklijke Cooperatie Consun U.A., Solutia Europe N.V./S.A.Inventors: Harry W. C. Raaijmakers, Ernst Neeleman
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Patent number: 7683038Abstract: The present invention relates to percarboxylated polysaccharide selected from the group consisting of gellan, carboxymethylcellulose, pectic acid, pectin and hyaluronic acid derivatives; the process for their preparation and their use in the pharmaceutical, biomedical, surgical and healthcare fields.Type: GrantFiled: February 28, 2003Date of Patent: March 23, 2010Assignee: Fidia Farmaceutici S.p.A.Inventors: Davide Bellini, Vittorio Crescenzi, Andrea Francescangeli
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Publication number: 20100022461Abstract: Disclosed is tonovel cyclic derivatives having potent inhibiting effect on melanin formation and skin hyper-pigmentation activity with no adverse response to skin. They can be used as the therapeutics for treating and preventing the skin disease caused by over-reproduced melanin.Type: ApplicationFiled: July 2, 2007Publication date: January 28, 2010Applicant: WONKISOPHARM CO., LTD.Inventors: Hyun Chul Cho, Yonghyun Choi, Jonghan Yhei
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Publication number: 20090304723Abstract: The present invention relates to a novel family of monosaccharide derivatives and disaccharide derivatives and to a method of preparation thereof. A mono- and disaccharide derivatives according to the invention comprises at least one fatty acid ester and may further comprise one or more anionic groups and are useful for, inter alia, medical, pharmaceutical, cosmetic and food applications.Type: ApplicationFiled: April 20, 2009Publication date: December 10, 2009Inventors: Lucas Alfonsus T. Hilgers, Anneke Georgine Blom
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Patent number: 7615629Abstract: The present invention relates to novel methods and novel solid support materials for the tandem synthesis of two or more different oligonucleotides on the same solid support in one synthetic run. The methods involve novel support preparations comprised of two or more types of orthogonally protected anchor groups. Subsequent to the selective removal of the first of the respective protective groups, the first oligonucleotide is assembled on the deblocked anchor groups according to standard methods, preferably via phosphoramidite chemistry. Following the capping of said first oligonucleotide, the anchor groups blocked by a second type of protective group are selectively liberated and serve as the starting point for the assembly of a second oligonucleotide, and so forth. After completion of all the syntheses on the solid support, the oligonucleotides are released from the solid support and deprotected at the nucleobases, using standard methods.Type: GrantFiled: December 31, 2002Date of Patent: November 10, 2009Assignee: Sigma-Aldrich Co.Inventor: Khalil Arar
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Publication number: 20090264525Abstract: The present invention relates to fatty acid esters of polyols or sulfonated fatty acid esters or sulfonated fatty acid amides containing at least one group Y, where Y stands for CF3—(CH2)a—O—, SF5—, CF3—(CH2)a—S—, CF3CF2S—, [CF3—(CH2)a]2N— or [CF3—(CH2)a]NH—, where a stands for an integer selected from the range from 0 to 5, or formula (I), where Rf stands for CF3—(CH2)r—, CF3—(CH2)r—O—, CF3—(CH2)r—S—, CF3CF2—S—, SF5—(CH2)t— or [CF3—(CH2)r]2N—, [CF3—(CH2)r]NH— or (CF3)2N—(CH2)r—, B stands for a single bond, O, NH, NR, CH2, C(O)—O, C(O), S, CH2—O, O—C(O), N—C(O), C(O)—N, O—C(O)—N, N—C(O)—N, O—SO2 or SO2—O, R stands for alkyl having 1 to 4 C atoms, b stands for 0 or 1 and c stands for 0 or 1, q stands for 0 or 1, where at least one radical from b and q stands for 1, and r stands for 0, 1, 2, 3, 4 or 5, to processes for the preparation of these compounds, and to uses of these surface-active compounds.Type: ApplicationFiled: July 2, 2007Publication date: October 22, 2009Applicant: MERCK PATENT GMBHInventors: Wolfgang Hierse, Nikolai (Mykola) Ignatyev, Martin Seidel, Elvira Montenegro, Peer Kirsch, Andreas Bathe
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Publication number: 20090259033Abstract: A process for the production of an ester of a non-reducing sugar or sugar derivative comprises reacting the non-reducing sugar or sugar derivative with a triglyceride of a fatty acid or a fatty acid ester of a monohydric alcohol in air, substantially in the absence of a solvent and under heterogeneous reaction conditions in which the sucrose and alkyl ester or triglyceride are present as separate phases, at a temperature in the range of from 110° C. to 140° C., wherein the reaction is conducted in the presence of a potassium soap but in the absence of an alkaline component. The process enables esters of sugars and sugar derivatives to be produced at lower temperatures than hitherto and in a much simpler process.Type: ApplicationFiled: April 26, 2007Publication date: October 15, 2009Applicant: SEBUS LIMITEDInventors: Kenneth James, James Frederick Smith
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Publication number: 20090186833Abstract: Methods for the production of pectin hydrolysis products, the pectin hydrolysis products produced in this manner, as well as their use are described.Type: ApplicationFiled: April 1, 2009Publication date: July 23, 2009Applicant: Sudzucker AktiengesellschaftInventors: Markwart Kunz, Mohammad Munir, Manfred Vogel
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Patent number: 7527949Abstract: The invention is directed to immunogenic compositions comprising polysaccharides and polysaccharide-protein conjugates that are useful to induce or detect the production of antibodies specific for H. pylori. The invention is also directed to methods of purifying the H. pylori polysaccharides from bacteria. The polysaccharide may be incorporated into an immunogenic composition or used in vitro to assay for the presence of H. pylori antibodies in a sample or biological fluid.Type: GrantFiled: October 28, 2004Date of Patent: May 5, 2009Assignee: Wyeth Holdings CorporationInventors: Mario Artur Monteiro, James Fulginiti, Deborah Ann Dilts
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Publication number: 20090054640Abstract: The present invention provides a method of controlling a chemical process, the method comprising the steps of: (i) providing a laminar flow of a first fluid, the first fluid providing a first reagent or one or more precursor thereof), a laminar flow of a second fluid, the second fluid providing a second reagent (or one or more precursor thereof) and a laminar flow of barrier fluid; and (ii) causing the first and barrier fluids to contact one another so that the barrier fluid forms a barrier between the first reagent (or one or more precursor thereof) and the second reagent (or one or more precursor thereof) wherein step (ii) comprises forming segments of first fluid encased or sandwiched by barrier fluid, the segments being surrounded by the second fluid, and the barrier fluid is permeable to one or both of the first and second reagents. Devices for performing the method of the present invention are also provided.Type: ApplicationFiled: December 20, 2006Publication date: February 26, 2009Inventors: Victoria Louise Workman, Robert Huw Davis, Daniel David Palmer
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Publication number: 20080319185Abstract: A method to synthesize benzyl group protected alpha-pentagalloylglucose (?-PGG) and related compounds. The method comprises the steps of: suspending a highly reactive acylation agent and an acylating catalyst in a donor solvent; adding ?-D-glucose or an analogue thereof to the mixture; reacting the mixture at room temperature for a time sufficient for reaction to occur; evaporating the solvent; taking up the residue in an appropriate solvent; filtering the residue and solvent mixture; and evaporating off the solvent.Type: ApplicationFiled: January 24, 2005Publication date: December 25, 2008Applicant: Ohio UniversityInventors: Klaus B. Himmeldirk, Xiaozhuo Chen
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Publication number: 20080206820Abstract: The present invention provides methods for labeling One or two oxygen atom(s) in a carboxyl group of a carboxyl-containing compound with an oxygen isotope selected from oxygen-17 (17O) or oxygen-18 (18O). The methods of the present invention are characterized in that an activated ester of the carboxyl-containing compound (carboxylic acid) is reacted with H217O or H218O in the presence of an activator. In the methods of the present invention, the reaction between the activated ester of a carboxylic acid and H217O or H218O can be allowed to proceed without including drastic conditions such as strongly acidic conditions or alkaline hydrolysis because an activator is used.Type: ApplicationFiled: May 20, 2005Publication date: August 28, 2008Inventors: Shigeyuki Yokoyama, Kazuhiko Yamada, Toshio Yamazaki
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Publication number: 20080171721Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.Type: ApplicationFiled: September 14, 2007Publication date: July 17, 2008Inventor: Bahram Memarzadeh
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Publication number: 20080076724Abstract: A polygalatenoside useful as an antidepressant agent having the formula is disclosed: wherein R, R? and R? independently are H or R1, provided that R, R? and R? are not all H, wherein R1 is wherein R2 is hydrogen, C1-C6 alkyl, C1-C6 alkoxy or halogen; or a pharmaceutically acceptable salt thereof. Preferably, R2 is H.Type: ApplicationFiled: September 21, 2006Publication date: March 27, 2008Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Mo-Chi Cheng, Feng-Nien Ko, Tian-Shung Wu
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Patent number: 7304153Abstract: Polyol polyesters useful as nondigestible fat substitutes are prepared by improved heterogeneous interesterification processes between fatty acid esters of easily removable alcohol and polyol characterized by having one or more improvements such as using low levels of soap emulsifying agent, catalyst, and/or excess fatty acid ester; reducing the size of the polyol by mechanical means; removing extraneous particulate material during the reaction; using low temperature and/or high pressure and compensating by increasing the mass transfer area; and/or using backmixing in the initial stage(s) and plug-flow conditions in the final stage(s).Type: GrantFiled: December 20, 1994Date of Patent: December 4, 2007Assignee: The Procter and Gamble Co.Inventors: Donald Benjamin Appleby, David Joseph Bruno, Jr., Patrick Joseph Corrigan, John Keeney Howie, Ju-Nan Kao, Scott David Pearson, Richard Gerard Schafermeyer, Glen Reid Wyness
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Patent number: 7276485Abstract: A flowable nondigestible oil composition having a Consistency in a temperature range of 20° C. to 40° C. of less than about 600 P.sec(n-1). The flowable nondigestible oil contains a liquid polyol polyester having a complete melt point less than 37° C., and a solid polyol polyester having a complete melt point of at least about 37° C., wherein the solid polyol polyester contains a solid saturated polyol polyester capable of forming crystallized spherulites.Type: GrantFiled: August 19, 1997Date of Patent: October 2, 2007Assignee: The Procter + Gamble Co.Inventors: Michael Kenneth Cerreta, Peter Yau-Tak Lin, Penelope Marie Edwards, Mark Lewis Agerton
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Patent number: 7135557Abstract: A method of making a carboxylated carbohydrate is disclosed, cellulose being a preferred carbohydrate material. Carboxylated cellulose fibers can be produced whose fiber strength and degree of polymerization is not significantly sacrificed. The method involves the use of a catalytic amount of a hindered cyclic oxammonium compounds as a primary oxidant and chlorine dioxide as a secondary oxidant in an aqueous environment. The oxammonium compounds may be formed in situ from their corresponding amine, hydroxylamine, or nitroxyl compounds. The oxidized cellulose may be stabilized against D.P. loss and color reversion by further treatment with an oxidant such as sodium chlorite or a chlorine dioxide/hydrogen peroxide mixture. Alternatively it may be treated with a reducing agent such as sodium borohydride. In the case of cellulose the method results in a high percentage of carboxyl groups located at the fiber surface.Type: GrantFiled: September 3, 2004Date of Patent: November 14, 2006Assignee: Weyerhaeuser CompanyInventors: S. Ananda Weerawarna, Joseph Lincoln Komen, Richard A. Jewell
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Patent number: 7074919Abstract: The invention concerns the use, in a composition for treating textile fiber articles in aqueous or moist medium, of an amphoteric polysaccharide, whereof the native skeleton is a polysaccharide consisting of a main chain comprising anhydrohexose units and branches comprising at least a neutral or anionic anhydropentose and/or anhydrohexose unit, the anhydrohexose and/or anhydropentose units being substituted of modified by groups bearing at least a (potentially) anionic load and/or at least a (potentially) cationic load, the degree of substitution or modification by the set of said groups bearing (potentially) anionic loads ranging between 0.01 and less than 3, with a ratio of the number of (potentially) anionic charges over the number of (potentially) cationic loads ranging between 99.5/0.Type: GrantFiled: December 20, 2001Date of Patent: July 11, 2006Inventors: Eric Aubay, Etienne Fleury, Ian Harrison
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Patent number: 7071327Abstract: A superabsorbent polysaccharide can be obtained by crosslinking a polysaccharide or derivative thereof with at least 1% by weight of a flexible spacer having a chain length of at least 9 chain atoms and having terminal activated coupling groups. The flexible spacer may comprise a polyalkyleneglycol with a molecular weight from about 400 to 10,000. The coupling groups may be provided by divinyl sulphone units.Type: GrantFiled: March 9, 2001Date of Patent: July 4, 2006Assignee: SCA Hygiene Products ABInventors: Guiseppe Mensitieri, Fabrizio Porro, Luigi Nicolais, Alessandro Sannino
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Patent number: 7063967Abstract: Aminoalkyl glucosaminide phosphate (AGP) compounds that are adjuvants and immunoeffectors are described and claimed. The compounds have a 2-deoxy-2-amino glucose in glycosidic linkage with an aminoalkyl (aglycon) group. Compounds are phosphorylated at the 4 or 6 carbon on the glucosaminide ring and comprise three 3-alkanoyloxyalkanoyl residues. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for using the compounds as adjuvants and immunoeffectors are also disclosed.Type: GrantFiled: January 8, 2002Date of Patent: June 20, 2006Assignee: Corixa CorporationInventors: David A. Johnson, C. Gregory Sowell
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Patent number: 7053209Abstract: The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.Type: GrantFiled: October 26, 2000Date of Patent: May 30, 2006Assignee: Durect CorporationInventors: John W. Gibson, Arthur J. Tipton
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Patent number: 7015200Abstract: The present invention provides compositions comprising at least one GHB moiety bonded to at least one physiologically compatible carrier molecule. The compositions can enhance the uptake of the drug, deliver effective therapeutic doses in a time-delayed fashion, or can target specific organs.Type: GrantFiled: September 21, 2001Date of Patent: March 21, 2006Assignee: Orphan Medical, Inc.Inventors: Mortimer Mamelak, William C. Houghton, Dayton T. Reardan, Brian L. Miller
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Patent number: 7001886Abstract: The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydramine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: GrantFiled: April 16, 2004Date of Patent: February 21, 2006Assignee: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, James R. Schleck, Vilas M. Chopdekar
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Patent number: 6974804Abstract: Acylated cellobiose compounds (CHME) which satisfy the formula; wherein X represents an acyl group (R—CO—) or H, Z represents an acyl group (R?—CO—) or H and not more than a minority of X+Z residues represent H, R represents a saturated or unsaturated, linear or branched chain hydrocarbon residue of 5 to 31 carbon atoms and R? represents a residue, different from R, which is: (i) a saturated or unsaturated, linear or branched chain hydrocarbon residue of 1 to 31 carbon atoms, or (ii) an aromatic hydrocarbon residue, or (iii) a cycloaliphatic hydrocarbon, each optionally substituted. CHME esters are particularly suited to thickening or structuring a water-immiscible liquid, for example, a phase in a cosmetic formulation, such as antiperspirant or deodorant formulations, eg water in oil emulsions and especially translucent ones.Type: GrantFiled: October 17, 2001Date of Patent: December 13, 2005Assignee: Unilever Home & Personal Care USA, division of Conopco, Inc.Inventors: Kevin Ronald Franklin, Andrew Hopkinson, Nicholas Webb, Michael Stephen White
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Patent number: 6965026Abstract: The subject invention pertains to nanoscale polyhedron-shaped molecules having molecular building blocks connected at their vertices. The subject invention also concerns methods of producing nanoscale polyhedrons utilizing a self-assembly reaction. The resultant molecules are faceted polyhedra that are porous, chemically robust, contain chemically accessible sites on their facets, and which are neutral and soluble in common laboratory solvents. The nanoscale polyhedrons can exhibit additional desirable physical properties, such as ferromagnetic properties.Type: GrantFiled: February 25, 2002Date of Patent: November 15, 2005Assignee: University of South FloridaInventors: Michael J. Zaworotko, Brian Moulton
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Patent number: 6958395Abstract: The present invention relates to a method by which saccharide compounds can be prepared in a very easy way. This method comprises the steps of: (a) attaching at least one saccharide to a cyclic or acyclic diene, (b) reacting the saccharide-containing diene obtained in step (a) or a commercially available saccharide-containing diene with a dienophile by Diels-Alder reaction.Type: GrantFiled: August 22, 2001Date of Patent: October 25, 2005Assignee: Deutsches Krebsforschungszentrum Stiftung des Offentlichen RechtsInventors: Manfred Wiessler, Hans-Christian Kliem, Bernd Sauerbrei, Birgit Schmauser
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Patent number: 6951934Abstract: The present invention relates to a novel method of chemically preparing functionalized derivatives of ?-(1,3)-glucans, enabling obtaining oligosaccharides which are free or which comprise specific groups such as, for example, sulphate, phosphate, methyl, in pre-defined positions. This method includes a reaction between a glycosyl donor of formula (Ia) or (Ib) and a glycosyl acceptor of formula (II), defined in the claims. Application: Preparation of biologically active compounds which can be used in the agricultural, cosmetic or pharmaceutical fields.Type: GrantFiled: February 2, 2001Date of Patent: October 4, 2005Assignee: Laboratories GoemarInventors: Jean-Claude Yvin, Frank Jamois, Vincent Ferrieres, Daniel Plusquellec
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Patent number: 6939856Abstract: The invention pertains to a method for preparing dexchlorpheniramine (“dexchlor”) tannate by reacting dexchlorpheniramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The dexchlorpheniramine free base may be obtained by reacting a commercially available dexchlorpheniramine salt such as dexchlorpheniramine maleate with a base such as aqueous sodium hydroxide. The resultant dexchlor tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: GrantFiled: August 14, 2003Date of Patent: September 6, 2005Assignee: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, Angelo R. Mellozzi, Vilas M. Chopdekar
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Patent number: 6939962Abstract: There is described a process for the synthesis of a sucrose-6-ester comprising: (a) reacting a mixture comprising sucrose and a polar aprotic solvent with an organotin-based acylation promoter, while adding a solvent capable of removing water by co-distillation, and removing water by co-distillation, to afford a first reaction mixture which is substantially free from water, followed by (b) adding a carboxylic anhydride to said first reaction mixture to afford a second reaction mixture, and maintaining said second reaction mixture at a temperature and for a period of time sufficient to produce a sucrose-6-ester, characterised in that step (a) is performed at a temperature of from 85 to 125° C. and at a pressure of from 20 to 80 kPa. In the most preferred embodiment, the polar aprotic solvent is DMF, the solvent capable of removing water by co-distillation is cyclohexane, the organotion-based acylation promoter is a 1,3-diacyloxy-1,1,3,3-tetrabutyldistannoxane, and step (a) is performed at approximately 97° C.Type: GrantFiled: July 19, 2001Date of Patent: September 6, 2005Assignee: Tate & Lyle Public Limited CompanyInventors: Jason D. Clark, Richard R. LeMay, Jr.
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Patent number: 6900310Abstract: This invention relates to processes for the production of purified, partially esterified polyol fatty acid polyesters and the compositions derived from those processes. The purified, partially esterified polyol fatty acid polyesters of the present invention are particularly well suited for use in a variety of food, beverage, pharmaceutical, and cosmetic applications and comprise less than about 5% by dry weight of polyol; less than about 5 ppm of residual solvent; less than about 700 ppm of lower alky esters; less than about 5% by dry weight of a soap and free fatty acid mixture; and less than about 3% by dry weight of ash. The compositions have an acid value of less than about 6.Type: GrantFiled: May 28, 2002Date of Patent: May 31, 2005Assignee: The Procter & Gamble CompanyInventors: Jared John Schaefer, James Earl Trout
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Patent number: 6891036Abstract: The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of formula (I): useful in the synthesis of nucleotides.Type: GrantFiled: May 27, 2003Date of Patent: May 10, 2005Assignee: Inalco S.p.A.Inventors: Giancarlo Tamerlani, Liana Salsini, Ilaria Lombardi, Debora Bartalucci, Giovanni Cipolletti
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Patent number: 6867194Abstract: Sugar-modified SIN-1 compositions are provided. The compositions are useful for generating NO in response to hydrolytic activity of a glycosidase specific for the O-glycosidic bond between the sugar and SIN-1 moieties. Pharmaceutical compositions containing the sugar-modified SIN-1 compositions and methods of using the compositions are also provided.Type: GrantFiled: August 9, 2001Date of Patent: March 15, 2005Assignee: Wayne State UniversityInventors: Peng George Wang, Xuejun Wu, Xiaoping Tang
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Patent number: 6846916Abstract: The present invention relates to a low temperature, solvent-free trans-acidolysis process for preparing surface-active carbohydrate fatty-acid esters comprising the steps of: (e) reacting acylated carbohydrate with free fatty acid in the presence of acid catalyst, under reduced pressure, and without adding any solvent; (f) decolorizing and separating the reaction mixture obtained in step (a) into unreacted fatty acid layer and a carbohydrate fatty-ester layer; (g) precipitating out the unreacted acylated carbohydrate; (h) librating the hydroxyl groups by partial hydrolysis in the presence of an acid catalyst; (i) removing the unreacted free fatty acids and unreacted carbohydrate esters of low molecular-weight carboxylic acids during purification, and recycling the removed unreacted free fatty acids and carbohydrate esters to the starting reactant mixture.Type: GrantFiled: January 15, 2002Date of Patent: January 25, 2005Assignee: URAH Resources (Nigeria) Ltd.Inventor: Olobo Jonathan Obaje
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Patent number: 6846917Abstract: Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides the basis for the preparation of combinatorial libraries and parallel libraries of defined glycosaminoglycan oligosaccharides. The defined glycosaminoglycan structures may be used in high-throughput screening experiments to identify carbohydrate sequences that regulate a host of recognition and signal-transduction processes. The determination of specific sequences involved in receptor binding holds great promise for the development of molecular tools which will allow modulation of processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. Notably, the present invention enables the automated synthesis of glycosaminoglycans in much the same fashion that peptides and oligonucleotides are currently assembled.Type: GrantFiled: January 22, 2002Date of Patent: January 25, 2005Assignee: Massachusetts Institute of TechnologyInventors: Peter H. Seeberger, Hernan Orgueira, Peter Schell
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Patent number: 6844328Abstract: The present invention is related to polysaccharide esters of N-derivatives of glutamic acid (N-GA derivatives). These polysaccharidic esters have antiproliferative activity and are characterized by a low systemic toxicity. The esters of the invention are used in the prevention and therapy of diseases caused by cellular hyperproliferation, particularly psoriasis, tumors, rheumatoid arthritis, or intestinal inflammatory pathologies.Type: GrantFiled: March 16, 2001Date of Patent: January 18, 2005Assignee: Eurand Pharmaceuticals Ltd.Inventors: Giuliana Miglierini, Luca Stucchi, Alessandro Rastrelli
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Patent number: 6833360Abstract: The invention pertains to a method for preparing pseudoephedrine tannate by reacting pseudoephedrine free base at a temperature of about 70 to about 110° C. with tannic acid neat or as an aqueous slurry containing about 5 to about 30 wt. % water.Type: GrantFiled: December 20, 2002Date of Patent: December 21, 2004Assignee: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, James R. Schleck, Vilas M. Chopdekar
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Publication number: 20040247551Abstract: An external preparation characterized by comprising, as selected from gallic acid derivatives of the following formula (I), 1Type: ApplicationFiled: March 18, 2004Publication date: December 9, 2004Inventors: Atsushi Yokomaku, Taketoshi Ito, Megumi Aono, Shinichi Watanabe, Yuichi Nishida
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Patent number: 6828308Abstract: The present invention relates to compounds containing as active ingredients hyaluronic acid and polyvinylpyrrolidone, for the treatment of inflammatory, ulcerative and painful conditions of moist epithelial surfaces such as mucositis, stomatitis, vestibulitis, aphthous ulcerations, and Behcet's syndrome.Type: GrantFiled: February 22, 2002Date of Patent: December 7, 2004Assignee: Sinclair Pharmaceuticals, Ltd.Inventors: Marco Mastradonato, Gianluca Braguti
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Patent number: 6818657Abstract: The present invention relates to a ternary glucosyl complex which is a bioprecursor of at least one retinoic active ingredient for percutaneous application, having formula (I), wherein E represents a linear hydrocarbon spacer group that is branched or cyclized and has an aliphatic or aromatic content capable of containing one or several heteroatoms of oxygen and carrying one or several carbonyl groups; A represents a radical of a molecule of said retinoic active ingredient linked to the spacer group by a carboxylate function and n=1 or 2.Type: GrantFiled: September 28, 2001Date of Patent: November 16, 2004Assignee: Pierre Fabre Dermo-CosmetiqueInventors: Daniel Redoules, Roger Tarroux, Didier Fournier, Jean-Jacques Perie
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Publication number: 20040219234Abstract: Method for obtaining tannin by extracting plant resources with mangrove, acacia, pine, eucalyptus, oak, hemlock and the like with lower alcohol or lower alcohol/water, or extracting outer bark of radiata pine (Pinus radiata) with water, lower alcohol or lower alcohol/water, and an adhesive containing said extracted substance for adhering woody materials such as veneer.Type: ApplicationFiled: May 28, 2004Publication date: November 4, 2004Applicants: KABUSHIKI KAISHA WOOD ONE T/A WOOD ONE CO., LTD., MONASH UNIVERSITYInventors: Yusho Nakamoto, Toshihiko Tsunoda, Keiko Ono, Naoko Kaeyama, Yoshikazu Yazaki, Huijian Jiang, Frank Lawson, Peter Heinz Theodore Uhlherr
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Publication number: 20040198641Abstract: The present invention provides polymeric compounds that can form micelles in solutions. These compounds have a hydrophobic, core that is coupled to a plurality of hydrophilic moieties.Type: ApplicationFiled: January 9, 2004Publication date: October 7, 2004Inventors: Kathryn E. Uhrich, Lu Tian
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Publication number: 20040198667Abstract: The invention pertains to a method for preparing diphenhydramine tannate by reacting diphenhydramine free base at a temperature of about 75 to about 150° C. with tannic acid neat or as an aqueous slurry containing up to about 20 wt. % water. The diphenhydramine free base may be obtained by reacting a commercially available diphenhydranine salt such as diphenhydramine maleate with a base such as aqueous sodium hydroxide. The resultant diphenhydramine tannate has extended release properties and is useful in pharmaceutical compositions as an antihistamine for human beings.Type: ApplicationFiled: April 16, 2004Publication date: October 7, 2004Applicant: Jame Fine Chemicals, Inc.Inventors: Sham N. Redkar, Raja G. Achari, James R. Schleck, Vilas M. Chopdekar
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Publication number: 20040192906Abstract: Process for the preparation of O-acylated glucose derivatives, in particular O-acylated predominantly in the 6 position, by reaction of a carboxylic acid with an alkyl haloformate, so as to form a mixed anhydride, and then reaction of the mixed anhydride with glucose.Type: ApplicationFiled: February 24, 2004Publication date: September 30, 2004Applicant: L'OREALInventors: Jean-Christophe Henrion, Michel Philippe
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Publication number: 20040192905Abstract: The present invention relates to polymerizable monomers for applications in medicine and biotechnology and synthesis thereof. The polymerizable ligands containing NAcetyl Glucosamine bind more strongly to lysozyme than NAG itself. The binding is further enhanced when a spacer arm, for example 6-Amino Caproic Acid (6-ACA) is introduced in the structure.Type: ApplicationFiled: March 31, 2003Publication date: September 30, 2004Inventors: Mohan Gopalkrishna Kulkarni, Jayant Jagannath Khandare
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Publication number: 20040176317Abstract: The invention concerns disaccharides of formula (I) derived from &agr;-maltosyl fluoride, wherein R1 and R 2 are such as defined in Claim 1. Said disaccharides are useful as glycosyl donors in transglycosylation reactions catalysed by glycoside-hydrolases or in transfer reactions catalysed by transglycosylases during the preparation of oligosaccharides or polysaccharides.Type: ApplicationFiled: January 8, 2004Publication date: September 9, 2004Inventors: Lionel Greffe, Hugues Driguez
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Publication number: 20040175808Abstract: A novel process is provided for the preparation of ribofuranose sugar derivatives which are useful in the synthesis of branched-chain ribonucleoside inhibitors of HCV polymerase for the treatment of HCV infection. Also provided are useful intermediates obtained from the instant process.Type: ApplicationFiled: December 5, 2003Publication date: September 9, 2004Inventors: Kimberly A. Savary, Zhiguo J. Song, J. Michael Williams, Feng Xu
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Patent number: 4990404Abstract: An invention is a chemical process for complete destruction and safe disposition of hazardous organic chemicals carbonaceous chemicals. The invention also comprises the process for production of an inert polymer formed essentially of Carbon and Sulfur, and also comprises the new inert polymer, itself and articles made of the new polymer. This new polymer has many of the properties of refractory materials and is an inert non-inflammable cross-linked polymer that is relatively insoluble in all generally known solvents. In the process of the invention, a carbonaceous chemical and Sulfur is heated, in an atmosphere of Nitrogen at 500.degree. to 1500.degree. C. Waste gases including sulfur and sulfides are condensed, scrubbed and the sulfur recycled. The solids residue when analyzed by a mass spectrometer contains less than one (1) part per million (1 ppm) of unreacted organic chemical.Type: GrantFiled: October 2, 1989Date of Patent: February 5, 1991Assignee: Sultech, Inc.Inventor: Harold W. Adams