Plural Diverse Saccharides Containing (e.g., Hetero Polysaccharides, Etc.) Patents (Class 536/123)
  • Patent number: 10131715
    Abstract: The invention relates to plant-derived cellulose-containing particles useful as rheology modifiers and to a process for preparing cellulose-containing particles from plant material, which process involves treating said plant material with a peroxide reagent. The process can be controlled to produce cellulose-containing particle having a viscosity up to about 7500 or 8000 cps.
    Type: Grant
    Filed: March 18, 2014
    Date of Patent: November 20, 2018
    Assignee: CELLUCOMP LIMITED
    Inventors: David Hepworth, Eric Whale
  • Patent number: 9872909
    Abstract: Methods and compositions of the invention relate to the enhancement of specific immunotherapies in cancer treatment. In particular, aspects of the invention relate to novel approaches to boost immune function using a complex carbohydrate pharmaceutical compound alone or in combination with other targeted immunotherapy to increase the efficacy of immunotherapy of cancer.
    Type: Grant
    Filed: September 17, 2013
    Date of Patent: January 23, 2018
    Assignees: Galeotin Therapeutics, Inc., Providence Health & Services—Oregon
    Inventors: Peter G. Traber, William L. Redmond, Eliezer Zomer, Anatole Klyosov, Stefanie N. Linch
  • Patent number: 9649327
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: May 16, 2017
    Assignee: Galectin Therapeutics, Inc.
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Patent number: 9637561
    Abstract: Food, consumer, and industrial product packaging materials are provided by embodiments of the present invention. Films and laminates based on a combination of negatively charged polysaccharides are provided as such packaging materials. The films can be prepared by mildly treating soft wood with steam followed by alkali extraction and enzymatic treatment. Negatively charged non-cellulosic polysaccharides are isolated with weight average molecular weight Mw higher than 10,000 g/mol and molecular structure comprising a xylan main chain substituted with more than 15 molar % of glucuronic acid and more than 5 molar % arabinose. The negatively charged non-cellulosic polysaccharides can be casted from water solution on a suitable carrier and surface acetylated or coated with acetylated polysaccharide to obtain oxygen and water barrier packaging laminate. Inventive packaging materials can have strength at break above 55 MPa, elongation to break above 2.
    Type: Grant
    Filed: February 8, 2012
    Date of Patent: May 2, 2017
    Assignee: Advanced Polymer Technology AB
    Inventor: Paul Gatenholm
  • Patent number: 9625468
    Abstract: A method for isolating derivatives of general O-linked amino acids including derivatives of O-tyrosine linked kappa casein di-O-sulfo tetrasaccharide and of O-di-phospho serine linked bovine submaxillary mucin disaccharide is provided. These derivatives are isolated and analyzed by further enzymatically separating the N-linked oligosaccharides from the O-linked oligosaccharides and then cleave O-linked oligosaccharides by decreasing the pH levels such that de-amidations are allowed. This de-amidation results in individual O-linked glycan amino acid components removed from the original glycoprotein. The O-linked glycan amino acid components are thus isolated from the glycoprotein, and can be individually analyzed.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: April 18, 2017
    Inventor: Michael A. Madson
  • Patent number: 9586984
    Abstract: The present invention provides a one-pot method of preparing an unprotected ?-O-glycolipid. The first step involves contacting a protected ?-iodo sugar with a catalyst and a lipid comprising a hydroxy group, under conditions sufficient to prepare a protected ?-O-glycolipid. The second step involves deprotecting the protected ?-O-glycolipid under conditions sufficient to prepare the unprotected ?-O-glycolipid, wherein the contacting and deprotecting steps are performed in a single vessel. The present invention also provides a one-pot method of preparing an unprotected ?-O-glycolipid following the steps for the preparation of the unprotected ?-O-glycolipid.
    Type: Grant
    Filed: January 6, 2014
    Date of Patent: March 7, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Jacquelyn Gervay-Hague, Wenjun Du, Suvarn S. Kulkarni, Matthew Schombs
  • Patent number: 9481739
    Abstract: Method for preparing a branched glucan having a chain comprising a plurality of glucose units linked by alpha 1,4-glycoside bonds and a plurality of side-groups linked to said chain via another type of glycoside bonding, which side-groups comprise one or more glucose units, the method comprising contacting a glucose source with a polysaccharide—which polysaccharide is a glucan comprising a plurality of glucose units linked by alpha 1,4-glycoside bonds and is essentially linear or branched to a lesser extent than the branched glucan that is to be prepared—in the presence of an acid catalyst under polycondensation conditions, thereby forming the branched glucan.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: November 1, 2016
    Assignee: NEDERLANDSE ORGANISATIE VOOR TOEGEPAST-NATUURWETENSCHAPPELIJK ONDERZOEK TNO
    Inventors: Maurice Karel Hubertina Essers, Johannes Wilhelmus Timmermans, Jerome Villarama Diaz, Ronald Tako Marinus van den Dool, Theodoor Maximiliaan Slaghek
  • Patent number: 9394503
    Abstract: Process for recovery and separation of sugars and oil from plants where the stems and leaves of such plants have substantial levels of both sugars and oils.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: July 19, 2016
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Stephen P Long, Vijay Singh, Haibo Huang
  • Patent number: 9044406
    Abstract: An aqueous composition for an enteric hard capsule, a method of preparing an enteric hard capsule, and an enteric hard capsule prepared using the method. The aqueous composition for an enteric hard capsule includes an enteric base material, a capsule forming aid, and a neutralizing agent.
    Type: Grant
    Filed: October 13, 2009
    Date of Patent: June 2, 2015
    Assignee: SAMSUNG FINE CHEMICALS CO., LTD.
    Inventors: Jin Ryul Son, Hyon Ho Baek, Sung Wan Lee, Min Gyu Song, Jae Uk Cha, Eun Hee Park
  • Patent number: 8999354
    Abstract: The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: April 7, 2015
    Assignee: Sanofi Pasteur Inc.
    Inventor: Robert P. Ryall
  • Publication number: 20150079227
    Abstract: The present invention relates to rolling compound powders comprising hydrogenated or non-hydrogenated isomaltulose for applying to the surface of chewing gum core materials, chewing gum products comprising such rolling compound powders, processes for reducing the stickiness of compositions of chewing gum core materials by using hydrogenated or non-hydrogenated isomaltulose-containing rolling compound powders in chewing gum preparation processes as well as the use of hydrogenated or non-hydrogenated isomaltulose in rolling compound powders for applying to the surface of chewing gum core materials.
    Type: Application
    Filed: March 7, 2013
    Publication date: March 19, 2015
    Inventors: Tillmann Dörr, Jörg Bernard
  • Publication number: 20150080566
    Abstract: The invention relates to a process for the extraction of wood, comprising the following steps: providing wood particles, at least a first class and a second class, stacking a fine layer consisting of the first class wood particles over a further layer consisting of the second class wood particles, and extracting the wood particles using a liquid extractant, in which the extractant flows from the top downwards, first through the fine layer and then through the further layer, in which the wood particles of the first class are finer than the wood particles of the second class, and thus the fine layer has a lower permeability than the further layer.
    Type: Application
    Filed: February 2, 2012
    Publication date: March 19, 2015
    Applicant: LDA AG
    Inventor: Franz Wiesbeck
  • Patent number: 8975310
    Abstract: A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a CLogP value of at least 6.5.
    Type: Grant
    Filed: July 20, 2012
    Date of Patent: March 10, 2015
    Assignee: Brigham Young University
    Inventor: Paul B. Savage
  • Patent number: 8962822
    Abstract: The present invention provides a modified polyuronic acid represented by formula (1) or a salt thereof which is excellent in surface activity: wherein R1 is a hydrogen atom, a hydrocarbon group having 1 to 40 carbon atoms or the like; X is an oxygen atom, a sulfur atom or a —NH— group, with the proviso that a ratio value of [m/(m+n)] is from 0.3 to 1.0, and a plurality of the R1 groups being present in a molecule of the modified polyuronic acid or the salt thereof may be the same or different from each other but all of the R1 groups are not hydrogen atoms at the same time.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: February 24, 2015
    Assignee: Kao Corporation
    Inventors: Kouji Ohsaki, Kazuaki Sato, Yuri Okutani
  • Patent number: 8962824
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: February 24, 2015
    Assignee: Galectin Therapeutics, Inc.
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Patent number: 8946407
    Abstract: Provided are a fructosylated mangiferin, a preparation method therefor and a use thereof, wherein the fructosylated mangiferin has a structural formula represented by the following formula (I), the method for preparing the fructosylated mangiferin includes adding a substance with fructosylating enzymatic activity to a transformed liquid containing mangiferin for biotransformation reaction, so as to convert the mangiferin into the fructosylated mangiferin, wherein the transformed liquid contains the mangiferin and a glycosyl donor; as well as a use of the fructosylated mangiferin in preparation of a medicament for treatment of tumor-related diseases.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: February 3, 2015
    Assignee: Nanjing University of Technology
    Inventors: Bingfang He, Xueming Wu, Jianlin Chu, Bin Wu, Sen Zhang, Pingkai Ouyang
  • Patent number: 8927522
    Abstract: Provided herein are microalgal polysaccharide compositions and. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The invention also provides novel microalgal compositions useful for improving the health and appearance of skin. The invention also includes insoluble polysaccharide particles for application to human skin.
    Type: Grant
    Filed: March 29, 2010
    Date of Patent: January 6, 2015
    Assignee: Solazyme, Inc.
    Inventors: Anna Coragliotti, Scott Franklin, Anthony G. Day, Stephen M. Decker
  • Patent number: 8927706
    Abstract: A method of forming a sucrose-6-ester includes in sequence the steps of: a) contacting sucrose with a organotin-based acylation promoter in a solvent in the presence of a base selected from amines and basic alkali metal salts; b) removing water to form a tin-sucrose adduct; and c) contacting the tin-sucrose adduct with an acylating agent to form the sucrose-6-ester. The sucrose-6-ester may then be converted to sucralose.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: January 6, 2015
    Assignee: Tate & Lyle Technology, Ltd.
    Inventors: Thomas Kennedy Hutton, Peter Jay Seaberg, Christopher C. Kerwood
  • Publication number: 20140377838
    Abstract: Compositions and methods for stabilizing biomolecules are disclosed. Specifically, the compositions include novel homopolymers or copolymers containing trehalose side chains conjugated to biomolecules. When such homopolymers or copolymers are placed in close proximity to biomolecules, such as proteins, the homopolymers or copolymers protect and/or stabilize the biomolecule. The compositions and methods may be suitable for use in various industries such as healthcare (pharmaceuticals), molecular biology, biofuels, paper, personal care, detergent, photographic, rubber, brewing, dairy and food processing industries.
    Type: Application
    Filed: January 25, 2013
    Publication date: December 25, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Heather D. Maynard, Rock J. Mancini, Juneyoung Lee, En-Wei Lin
  • Publication number: 20140378556
    Abstract: The presently disclosed subject matter concerns a microbial biopolymer comprising fucose in its composition. This biopolymer consists of a polysaccharide comprising fucose, which represents at least 10% of its composition. This fucose-containing polysaccharide also contains non-sugar components, namely, acyl group substituents. This disclosed subject matter also concerns the process for the production of the biopolymer, which is obtained cultivation of the bacterium Enterobacter A47 (DSM 23139), using glycerol or glycerol-rich mixtures as carbon sources. The fucose-containing biopolymer of the presently disclosed subject matter may be used in several industrial applications (e.g. pharmaceutical, cosmetics and agro-food industries) and in the treatment of industrial wastes (e.g. oil and metal recovery).
    Type: Application
    Filed: May 12, 2014
    Publication date: December 25, 2014
    Applicant: 73100- SETENTA E TRES MIL E CEM, LDA.
    Inventors: Maria D'Ascencao Carvalho Fernandes De Miranda Reis, Rui Manuel Freitas Oliveira, Maria Filomena Andrade De Freitas, Vitor Manuel Delgado Alves
  • Publication number: 20140370579
    Abstract: Dandelion processes, compositions and products are provided. One process is a method of preparing dandelion that utilizes a species of a Taraxacum genus, the process including the steps of extracting and recovering a rubber and a carbohydrate from a dandelion root substantially simultaneously. The process employs a dandelion species that is selected from the group consisting of: Taraxacum officianale, Taraxacum kok-saghyz, a rubber-bearing species of the genus Taraxacum, and a combination of two or more thereof. This Abstract is provided for the sole purpose of complying with the Abstract requirement rules that allow a reader to quickly ascertain the subject matter of the disclosure contained herein. This Abstract is submitted with the explicit understanding that it will not be used to interpret or to limit the scope or the meaning of the claims.
    Type: Application
    Filed: March 7, 2014
    Publication date: December 18, 2014
    Inventors: Daniel Swiger, James Wade
  • Publication number: 20140350238
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Application
    Filed: August 11, 2014
    Publication date: November 27, 2014
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Patent number: 8889637
    Abstract: The present invention relates to novel polymorphs of the trisaccharide 2?-O-fucosyllactose (2-FL) of formula (1), methods for producing said polymorphs and their use in pharmaceutical or nutritional compositions.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: November 18, 2014
    Assignee: Glycom A/S
    Inventors: Károly Ágoston, István Bajza, Gyula Dekany, Péter Trinka, Ágnes Ágoston, Gábor Kádár, Sándor Demkó, Ignacio Figueroa-Pérez, Markus Hederos, Ferenc Horváth, Andreas Schroven, Ioannis Vrasidas, Piroska Kovács-Pénzes, Christian Risinger, László Kalmár, Gergely Pipa, Julien Boutet, Lars Kröger, Christoph Röhrig
  • Patent number: 8871925
    Abstract: Aspects of the invention provide compositions for use in the treatment galectin-dependent diseases. In particular, compositions comprising a selectively depolymerized, branched galactoarabino-rhamnogalacturonate whose backbone is predominantly comprised of 1,4-linked galacturonic acid (GalA) moieties, with a lesser backbone composition of alternating 1,4-linked GalA and 1,2-linked rhamnose (Rha), which in-turn is linked to any number of side chains, including predominantly 1,4-b-D-galactose (Gal) and 1,5-a-L-arabinose (Ara) residues.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: October 28, 2014
    Assignee: Galectin Therapeutics Inc.
    Inventors: Eliezer Zomer, Peter G. Traber, Anatole A. Klyosov, Elena Chekhova
  • Publication number: 20140314739
    Abstract: The present invention provides a composition comprising or consisting of inulin particles for use in the reduction or inhibition of inflammation, and/or for treating or preventing inflammatory disease, in a subject. Also provided is a pharmaceutically acceptable composition comprising: particles of inulin; and a substance comprising or consisting of one or more pathogen-associated molecular patterns (PAMPs), or an equivalent kit of parts, and methods and uses of the composition and kit for inducing or modulating an immune response in a subject, such as modulating an immune response to an antigen or allergen and/or as a vaccine. Also provided is a single-dose vaccine composition comprising inulin particles, an antigen and, optionally, an antigen-binding carrier material, and methods and uses of the vaccine.
    Type: Application
    Filed: June 19, 2012
    Publication date: October 23, 2014
    Applicant: Vaxine Pty Ltd.
    Inventor: Nikolai Petrovsky
  • Publication number: 20140314722
    Abstract: The present invention discloses a matrix comprising a modified polysaccharide consisting of repeating disaccharide units whereby in at least 11% of the disaccharide units one primary alcohol group is oxidized into a carboxylic acid group.
    Type: Application
    Filed: August 17, 2012
    Publication date: October 23, 2014
    Applicant: ALBERT-LUDWIGS UNIVERSITÄT FREIBURG
    Inventors: V. Prasad Shastri, Aurelien Forget
  • Publication number: 20140243518
    Abstract: The present invention relates to a method for preparing cationic galactomannans, comprising the following steps: a) a step in which galactomannans are impregnated with an alkaline agent; b) a step in which the mixture formed in step a) is impregnated with a cationic agent; and c) a step in which the mixture is formed in step b) is dried.
    Type: Application
    Filed: October 3, 2012
    Publication date: August 28, 2014
    Inventors: Jean-Claude Le-Thiesse, Sebastien Lomel, Thierry Gisbert
  • Patent number: 8809521
    Abstract: Dispersions that comprise insoluble alginate/gelling ion particles in an alginate solution, wherein the dispersion exhibits less than 10% of final gel storage modulus after one minute in the absence of addition of non-gelling cations are disclosed. Kits and compositions for making such dispersions are disclosed and methods for making and using the dispersions, and the components used in the dispersions are also disclosed.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: August 19, 2014
    Assignee: FMC Biopolymer AS
    Inventors: Jan Egil Melvik, Jorunn E. Bjornstad, Terje Svendsen
  • Publication number: 20140221643
    Abstract: Provided are a fructosylated mangiferin, a preparation method therefor and a use thereof, wherein the fructosylated mangiferin has a structural formula represented by the following formula (I), the method for preparing the fructosylated mangiferin includes adding a substance with fructosylating enzymatic activity to a transformed liquid containing mangiferin for biotransformation reaction, so as to convert the mangiferin into the fructosylated mangiferin, wherein the transformed liquid contains the mangiferin and a glycosyl donor; as well as a use of the fructosylated mangiferin in preparation of a medicament for treatment of tumor-related diseases.
    Type: Application
    Filed: March 8, 2012
    Publication date: August 7, 2014
    Applicant: NANJING UNIVERSITY OF TECHNOLOGY
    Inventors: Bingfang He, Xueming Wu, Jianlin Chu, Bin Wu, Sen Zhang, Pingkai Ouyang
  • Publication number: 20140220643
    Abstract: A method for the production of an arabinoxylan-enriched preparation from a pentosan fraction derived from a wheat flour comprising the following sequential steps: mixing the pentosan fraction with water to obtain a pentosan slurry; centrifuging the slurry to obtain liquid and solid phases; and drying the liquid phase to provide the arabinoxylan-enriched preparation. Also provided are methods for the production of: a starch- and protein-enriched intermediate from wheat flour; a glucose-enriched preparation from wheat flour; and a starch- and protein-enriched material from wheat flour. Furthermore, there is provided a use of an arabinoxylan-enriched preparation in one or more of: food, immune stimulants, prebiotics, nutraceuticals, pharmaceuticals and food supplements. There is also an apparatus for the production of an arabinoxylan-enriched preparation from a pentosan fraction of wheat flour.
    Type: Application
    Filed: June 19, 2012
    Publication date: August 7, 2014
    Applicant: MANCHESTER METROPOLITAN UNIVERSITY
    Inventor: Weili Li
  • Patent number: 8785417
    Abstract: Absorbent boronate-galactomannan complexes comprising a hydrophobic group are disclosed. The boronate-galactomannan complexes are solid materials capable of gel forming upon contacting with liquids. The boronate-galactomannan complexes are particularly suitable for absorbing liquids.
    Type: Grant
    Filed: February 6, 2009
    Date of Patent: July 22, 2014
    Assignee: Archer Daniels Midland Co.
    Inventors: Anne-Claude Couffin, Mohammed Berrada, André Laforest, Nicolas Nourry
  • Publication number: 20140178439
    Abstract: A method of preparing a capturing agent for a selected biopolymer or bioparticle, includes the steps of: a) selecting a desired biopolymer or bioparticle, and b) providing a support matrix modified to have, at predetermined conditions, such a net negative surface charge and net surface hydrophobicity in relation to the net negative surface charge and the net surface hydrophobicity of the selected biopolymer or bioparticle that the modified support matrix is capable of selective interaction and capture of the biopolymer or bioparticle through a resulting net hydrophobic interaction being the actual hydrophobic interaction minus the actual electrostatic repulsion. The use of such a capturing agent as a therapeutically active substance, as well as in chromatography and diagnosis are also disclosed.
    Type: Application
    Filed: July 20, 2012
    Publication date: June 26, 2014
    Inventor: Stellan Hjerten
  • Patent number: 8741314
    Abstract: The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: June 3, 2014
    Assignee: Sanofi Pasteur, Inc.
    Inventor: Robert P. Ryall
  • Patent number: 8734813
    Abstract: The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 27, 2014
    Assignee: Sanofi Pasteur, Inc.
    Inventor: Robert P. Ryall
  • Patent number: 8722645
    Abstract: Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-PDGF receptors; (ii) synaptophysin; (iii) zvegf3; (iv) CCR1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) matrix metalloproteinases MMP 2 and MMP9; (viii) matrix metalloproteinase inhibitors TIMP1 and TMP2; (ix) integrins; (x) TFG-?1; (xi) endothelin receptor antagonists; and (xii) collagen synthesis and degradation modulating compounds; (xiii) actin synthesis and degradation modulating compounds; and (xiv) tyrosine kinases is administered to an animal in order to treat fibrosis.
    Type: Grant
    Filed: July 17, 2012
    Date of Patent: May 13, 2014
    Assignee: Galectin Therapeutics Inc.
    Inventors: David Platt, Eliezer Zomer, Anatole Klyosov
  • Patent number: 8722062
    Abstract: The present invention describes a combined vaccine that offers broad protection against meningococcal disease caused by the pathogenic bacteria Neisseria meningitidis. The vaccine is comprised of four distinct polysaccharide-protein conjugates that are formulated as a single dose of vaccine. Purified capsular polysaccharides from Neisseria meningitidis serogroups A, C, W-135, and Y are chemically activated and selectively attached to a carrier protein by means of a covalent chemical bond, forming polysaccharide-protein conjugates capable of eliciting long-lasting immunity to a variety of N. meningitidis strains in children as well as adults.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: May 13, 2014
    Assignee: Sanofi Pasteur, Inc.
    Inventor: Robert P. Ryall
  • Patent number: 8691976
    Abstract: A low-glycemic available carbohydrate composition of the invention contains the following components: (i) 5-60 wt. % of one or more monosaccharides selected from monosaccharides other than glucose and fructose, in particular galactose, ribose and mannose; (ii) 15-95 wt. % of oligosaccharides having a length of 2 to 20 anhydromonose units, at least half of which are anhydroglucose units linked by non-?-1,4 bonds; these oligosaccharides preferably comprising disaccharides such as palatinose, isomaltose and trehalose and/or non-?-1,4 linked higher glucose-containing oligosaccharides; (iii) 0-45 wt. % of other available carbohydrates, such as glucose and maltodextrins. This carbohydrate composition can be part of a food composition for the treatment of diabetes, obesitas, insulin resistance, or for postprandial glucose response.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: April 8, 2014
    Assignee: N.V. Nutricia
    Inventors: Katrien Maria Jozefa van Laere, Houkje Bouritius, Mirian Lansink
  • Publication number: 20140094430
    Abstract: The invention relates to the use of an additive to stabilise hyaluronic acid formulated in an aqueous composition against the degrading effect of heat or of enzymes such as hyaluronidase, characterised in that said additive comprises one or more polysaccharides having a molecular weight equal to or greater than 20,000 daltons and solubility in water at least equal to or greater than 1 g/l, the total concentration of said polysaccharide(s) and hyaluronic acid in the composition giving it a viscosity of at least 500 cP, which is particularly suitable for intra-articular, intradermal or intraocular administration to humans or animals.
    Type: Application
    Filed: December 16, 2011
    Publication date: April 3, 2014
    Applicant: ALTERGON S.A.
    Inventors: Carlo Vernasca, Andrea Maria Giori, Stefano Togni
  • Publication number: 20140088252
    Abstract: A method for preparing a specific product from a polysaccharide in which at least one hydroxyl of a saccharide unit is substituted with an ether or ester moiety. The ether or ester moiety is provided with ethenyl and/or epoxy functionality for preparing an activatable polysaccharide polymer and the activatable polysaccharide polymer with ethenyl and/or epoxy functionality is optionally reacted with an additional coupling reagent, having at least two coupling functionality for preparing polysaccharide polymer with additional activatable crosslinker.
    Type: Application
    Filed: March 22, 2012
    Publication date: March 27, 2014
    Applicant: Teknologian Tutkimuskeskus Vtt
    Inventors: Ali Harlin, Harri Setälä, Helinä Talja
  • Publication number: 20140065062
    Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.
    Type: Application
    Filed: November 4, 2013
    Publication date: March 6, 2014
    Inventor: Bahram Memarzadeh
  • Patent number: 8658787
    Abstract: Aspects of the invention provide methods for treatment of nonalcoholic steatohepatitis and associated liver fibrosis. In particular, aspects of the invention relate to the use of a therapeutic formulation comprising a galacto-rhamnogalacturonate compound for the treatment of nonalcoholic steatohepatitis and associated liver fibrosis.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: February 25, 2014
    Assignee: Galectin Therapeutics Inc.
    Inventors: Peter G. Traber, Eliezer Zomer, Anatole A. Klyosov
  • Publication number: 20140017732
    Abstract: The present application describes a dilute two-loop method for treating biomass in the production of biofuels such as ethanol. The method involves washing the biomass to dissolve sugars that are associated with the biomass, and separating the washed biomass into a solids phase and a liquids phase. The solids phase is pretreated to render the biomass more susceptible to hydrolysis under conditions that do not produce substantial amounts of sugars. The pretreated biomass is separated into a second solids phase and second liquid phase, and the second solids phase is saccharified and fermented. The first and second liquid phases are recycled to dilute the biomass at various stages of the process.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 16, 2014
    Applicant: Edeniq, Inc.
    Inventor: Edeniq, Inc.
  • Patent number: 8614314
    Abstract: Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also described.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: December 24, 2013
    Assignee: Momenta Pharmaceuticals, Inc.
    Inventors: Roy Sucharita, Takashi Kei Kishimoto, Ganesh Venkataraman
  • Patent number: 8598128
    Abstract: Fructosylated puerarin being converted from puerarin by a bioconversion method conducted in an aqueous phase or nonaqueous phase system, including monofructosyl-(2,6)-puerarin, bifructosyl-(2,6)-puerarin, trifructosyl-(2,6)-puerarin, tetrafructosyl-(2,6)-puerarin and pentafructosyl-(2,6)-puerarin. Tests have shown that the oligosaccharylated puerarin is effective to treat acute myocardial ischemia, and can markedly suppress in vitro the proliferation of human breast cancer cell strain MDA-MB-23 and human chronmyelogenors leukemia cell strain K562, and it has a low toxicity.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: December 3, 2013
    Inventors: Bingfang He, Xueming Wu, Jianlin Chu, Bin Wu, Sen Zhang, Pingkai Ouyang
  • Publication number: 20130315990
    Abstract: The invention provides formulations comprising isolated Disialyllacto-N-tetraose (DSLNT) or variants, isomers, analogs and derivatives thereof.
    Type: Application
    Filed: February 3, 2012
    Publication date: November 28, 2013
    Applicant: The Regents of the University of California
    Inventor: Lars Bode
  • Publication number: 20130316892
    Abstract: Provided are polymer particles which can be used at a high flow rate when used as a filler for chromatography, that is, has excellent resistance flow rate appropriate for processing in large quantities, and also has a high binding capacity for target molecules such as proteins when an appropriate ligand is contained in the particles, and a method for producing the polymer particles; specifically, crosslinked polymer particles and a method for producing the crosslinked polymer particles, polysaccharide composite particles and a method for producing the polysaccharide composite particles, a filler for chromatography using the polymer particles, and an adsorbent for antibody purification. Disclosed are: A.
    Type: Application
    Filed: December 14, 2011
    Publication date: November 28, 2013
    Applicant: JSR Corporation
    Inventors: Satoshi Nakamura, Tetsuo Fukuta, Kazuhiro Ikkyu, Yu Otani, Hiroshi Kawai
  • Patent number: 8592573
    Abstract: Thermoplastic heteropolysaccharide derivatives, articles employing such thermoplastic heteropolysaccharide derivatives and methods for making such thermoplastic heteropolysaccharide derivatives are provided.
    Type: Grant
    Filed: August 13, 2009
    Date of Patent: November 26, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Robert Lee Barcus, Alyssandrea Hope Hamad-Ebrahimpour, Alan Howard Ullman, Dean Van Phan, Mark Edwin Forry, John Collins Dyer, Timothy Duane Smith, Jeanette Marie Swartz, Yonas (NMN) Gizaw
  • Patent number: 8575333
    Abstract: The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation enhancers, anti-microbial effects, anti-fugal effects, facilitation of diagnostic procedures. The invention further includes methods of treatment and diagnostic kits.
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: November 5, 2013
    Inventor: Bahram Memarzadeh
  • Publication number: 20130288932
    Abstract: According to an embodiment, a method of providing a biopolymer comprises: cryodesiccating a broth, wherein the broth comprises: (A) a biopolymer, wherein the biopolymer is an exopolysaccharide; and (B) a liquid growth medium. According to certain embodiments, the biopolymer is produced by the fermentation of at least one carbohydrate via a microbe. According to an embodiment, the microbe is a bacterium. According to another embodiment, the microbe is a fungus.
    Type: Application
    Filed: April 27, 2012
    Publication date: October 31, 2013
    Applicant: HALLIBURTON ENERGY SERVICES, INC.
    Inventors: Andrew A.F. Mackenzie, Eric Davidson
  • Publication number: 20130259870
    Abstract: Aspects of the invention provides provide methods for treatment of NASH and associated liver fibrosis. In particular, aspects of the invention relate to the therapeutic formulation comprising a galactomannan polysaccharide compound for the treatment of NASH and associated liver fibrosis.
    Type: Application
    Filed: September 14, 2012
    Publication date: October 3, 2013
    Inventors: Peter G. Traber, Eliezer Zomer, Anatole A. Klyosov