Plural Diverse Saccharides Containing (e.g., Hetero Polysaccharides, Etc.) Patents (Class 536/123)
  • Patent number: 6818761
    Abstract: A polysaccharide of Echinacea angustifolia roots, having molecular weight of 1.3×105 Da and including rhamnose, arabinose, galactose and galacturonic acid in ratio 0.5:2.5:1.75:10.25, is recovered from spontaneous or cultivated Echinacea angustifolia roots by means process including the following steps: a) depriving the roots of non polysaccharidic constituents by extraction with solvent; b)extracting the polysaccharidic fraction from the roots as directly obtained from the preceding step; c) isolating the polysaccharide by chromatography of the polysaccharidic fraction. Due to its immune-stimulating properties, the polysaccharide can be used for the preparation of medicaments, food supplements or nutraceutical compositions to administer whenever it is desirable to strenghthen the immune system body defenses.
    Type: Grant
    Filed: November 25, 2002
    Date of Patent: November 16, 2004
    Assignee: Indena S.p.A.
    Inventors: Andrea Giori, Alessandro Anelli, Paolo Morazzoni, Francesco Di Pierro
  • Publication number: 20040220389
    Abstract: One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.
    Type: Application
    Filed: February 6, 2004
    Publication date: November 4, 2004
    Inventors: Stephen L. Buchwald, Obadiah J. Plante, Peter H. Seeberger
  • Publication number: 20040219217
    Abstract: The present invention relates to the use of fibres of polysaccharide polymers of natural origin, preferably of vegetal origin, such as for instance cellulose or cotton, or the use of yarns, non-woven fabrics (or felts), or fabrics obtained from said fibres in order to obtain pharmaceutical, cosmetic or hygienic products, or products to be used in the household or in the food industry. In particular, the polysaccharide polymers according to the invention can be used to obtain plasters, gauzes, sanitary cotton wool, vaginal and surgical tampons, bandages, gloves, stockings, masks, curtains, carpets and the like, or to obtain filters or wrappings for food.
    Type: Application
    Filed: June 14, 2004
    Publication date: November 4, 2004
    Inventors: Ivo Volpato, Bernard Emile Bizzini, Roberto Carlos Abreu, Marco Lippmann
  • Publication number: 20040220141
    Abstract: A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization.
    Type: Application
    Filed: June 1, 2004
    Publication date: November 4, 2004
    Applicant: Chromaceutical Advanced Technologies, Inc.
    Inventors: Robert A. Beck, Robert A. Mateer
  • Publication number: 20040214293
    Abstract: The present invention relates to a novel microorganism and a method for producing fructooligosaccharides and neofructooligosaccharides.
    Type: Application
    Filed: May 18, 2004
    Publication date: October 28, 2004
    Inventors: Joon Sang Han, Kang June Park, Dae Sub Shin, Jung Hoon Kim, Jin Chul Kim, Ki Chang Lee, Woon Hwa Lee, Seung Wook Kim, Seung Won Park
  • Publication number: 20040197410
    Abstract: The object of the present invention is to overcome conventional demerits of pullulan powders prepared by conventional techniques, i.e., they could not be homogeneously mixed with non-reducing saccharides composed of glucose units when mixed together, and the resulting mixtures do not easily dissolve in water; and to provide a pullulan-containing powder with an improved rate of water dissolution, as well as to provide preparations and uses thereof. The present invention solves the above object by providing a pullulan-containing powder which uniformly comprises pullulan as a main ingredient and a non-reducing saccharide, and their process and uses; wherein the pullulan-containing powder is prepared by the steps of preparing a solution dissolving pullulan and a non-reducing saccharide homogeneously, pulverizing the solution, and collecting the resulting pullulan-containing powder.
    Type: Application
    Filed: January 20, 2004
    Publication date: October 7, 2004
    Inventors: Toshiyuki Sugimoto, Toshio Miyake
  • Publication number: 20040197877
    Abstract: The present invention concerns a new epoxypolysaccharide-producing bacterium, the exopolysaccharide isolated from this bacterium and the use of the exopolysaccharide.
    Type: Application
    Filed: October 24, 2003
    Publication date: October 7, 2004
    Inventors: Werner Lubitz, Ewald B.M. Denner
  • Publication number: 20040192907
    Abstract: A dry hydrocolloid powder with cold-gel capabilities is produced by: dissolving a hydrocolloid comprising polysaccharide chains in an aqueous solution; heating the dissolved hydrocolloid solution to a temperature and for a time sufficient to induce a substantial alteration in the tertiary structure of the polysaccharide chains of the hydrocolloid; cooling the dissolved hydrocolloid solution to a temperature and for a time sufficient to substantially return the polysaccharide chains of the hydrocolloid to their original tertiary structure, wherein the polysaccharide chains form a gelling network; and drying the cooled hydrocolloid solution to form a dry powder. In some embodiments, the dry powder has a viscosity of between about 10 and 40 mPa-s when reconstituted in a 2% weight/weight solution at 25 degrees C. In other embodiments, the dry powder has a water absorption of greater than 20 g H2O/g powder.
    Type: Application
    Filed: March 26, 2003
    Publication date: September 30, 2004
    Inventors: Jeffrey J. Resch, Christopher R. Daubert
  • Patent number: 6797275
    Abstract: This invention relates to conjugates of the Vi polysaccharide of S. typhi with the carrier Pseudomonas aeruginosa recombinant exoprotein A (rEPA), and compositions thereof, and to methods of using of these conjugates and/or compositions thereof for eliciting an immunogenic response in humans, including responses which provide protection against, or reduce the severity of, S. typhi bacterial infections. The conjugates, and compositions thereof, are useful as vaccines to induce serum antibodies againt S. typhi and are useful to prevent and/or treat illnesses caused by S. typhi.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: September 28, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Zuzana Kossaczka, Shousun Chen Szu, John B. Robbins
  • Publication number: 20040185537
    Abstract: The present invention describes two novel proteins having fructosyltransferase activity. Both enzymes are derived from lactobacilli, which are food-grade micro-organisms with the Generally Recognized As Safe (GRAS) status. One of these proteins produces an inulin and fructo-oligosaccharides, while the other produces a levan and fructo-oligosaccharides. According to the invention lactobacilli capable of producing an inulin and/or a levan and/or fructo-oligosaccharides using one or both of the fructosyltransferases can be used as a probiotic or a symbiotic.
    Type: Application
    Filed: March 4, 2004
    Publication date: September 23, 2004
    Inventors: Sacha Adrianus Fokke Taco Van Hijum, Gerritdina Hendrika Van Geel-Schutten, Lubbert Dijkhuizen, Hakim Rahaoui
  • Publication number: 20040175807
    Abstract: The present invention provides a protein having &bgr;1,3-galactosyltransferase activity, a DNA encoding the protein, a transformant comprising the DNA, a process for producing the protein using the transformant, and a process for producing a galactose-containing complex carbohydrate using the transformant.
    Type: Application
    Filed: April 28, 2004
    Publication date: September 9, 2004
    Inventors: Tetsuo Endo, Satoshi Koizumi
  • Publication number: 20040175806
    Abstract: The invention includes methods of processing plant material by adding water to form a mixture, heating the mixture, and separating a liquid component from a solid-comprising component. At least one of the liquid component and the solid-comprising component undergoes additional processing. Processing of the solid-comprising component produces oils, and processing of the liquid component produces one or more of glycerol, ethylene glycol, lactic acid and propylene glycol. The invention includes a process of forming glycerol, ethylene glycol, lactic acid and propylene glycol from plant matter by adding water, heating and filtering the plant matter. The filtrate containing starch, starch fragments, hemicellulose and fragments of hemicellulose is treated to form linear poly-alcohols which are then cleaved to produce one or more of glycerol, ethylene glycol, lactic acid and propylene glycol. The invention also includes a method of producing free and/or complexed sterols and stanols from plant material.
    Type: Application
    Filed: March 3, 2003
    Publication date: September 9, 2004
    Applicant: Battelle Memorial Institute
    Inventors: Todd A. Werpy, Andrew J. Schmidt, John G. Frye, Alan H. Zacher, James A. Franz, Mikhail S. Alnajjar, Gary G. Neuenschwander, Eric V. Alderson, Rick J. Orth, Charles A. Abbas, Kyle E. Beery, Catherine J. Kim
  • Publication number: 20040166109
    Abstract: The present invention relates to novel compounds and their pharmaceutical or diagnostic use, or use as a pharmacological target. More particularly, the present invention describes the identification of partners of the FE65 protein and the use of these partners, or of any compound which is capable of modulating, at least partially, their interaction with FE65, for regulating the activity of FE65, and in particular the phenomenon of intracellular transport or of endocytosis of the APP.
    Type: Application
    Filed: December 3, 2003
    Publication date: August 26, 2004
    Applicant: Aventis Pharma S.A.
    Inventors: Isabelle Maury, Luc Mercken, Alain Fournier
  • Publication number: 20040161835
    Abstract: The object of the present invention is to provide a polypeptide which can be used to produce a saccharide having the structure of cyclo{→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→6)-&agr;-D-glucopyranosyl-(1→3)-&agr;-D-glucopyranosyl-(1→}, a DNA encoding the polypeptide, and uses thereof.
    Type: Application
    Filed: July 11, 2003
    Publication date: August 19, 2004
    Inventors: Michio Kubota, Kazuhiko Maruta, Takuo Yamamoto, Shigeharu Fukuda
  • Publication number: 20040154052
    Abstract: The invention relates to a method for producing oligosaccharides, comprising [[of]] selecting a gene which codes for an enzyme which is capable of converting sucrose into an oligosaccharide; linking the gene to suitable transcription-initiation and transcription-termination signals in order to provide an expression construct; transforming a suitable plant cell with the expression construct; regenerating a transgenic plant from the transformed plant cell; culturing the transgenic plant under conditions enabling the expression and activity of the enzyme; and isolating the oligosaccharides from the transgenic plant. The invention further relates to the product obtained by means of the method and to the use thereof, in addition to transgenic plants and parts thereof which are capable of producing oligosaccharides.
    Type: Application
    Filed: October 21, 2003
    Publication date: August 5, 2004
    Applicant: Stichting Scheikundig Onderzoek in Nederland
    Inventors: Josephus Christianus Maria Smeekens, Michael Johannes Marcus Ebskamp, Hendrikus Andrianus Maria Geerts, Petrus Jacobus Weisbeek
  • Patent number: 6770756
    Abstract: It is the object of the present invention to provide an industrially useful process for the manufacture of polyguluronic acids having degrees of polymerization less than 20 and substantially free of mannuronic acid contamination. Alginate salts of organic bases are quite soluble in aqueous solution, and remain soluble in aqueous solution throughout a hydrolysis reaction in the range of pH values at which the acidic hydrolysis is effected at a reasonably fast rate. Based on this finding, a solution containing 5 wt. % or more of alginic acid prepared by dissolving alginic acid in water by neutralization with an organic base is provided and then hydrolyzed under acidic conditions, followed by selective precipitation of polyguluronic acids under acidic conditions.
    Type: Grant
    Filed: July 20, 1999
    Date of Patent: August 3, 2004
    Assignee: Seiko Epson Corporation
    Inventor: William Alan Marritt
  • Publication number: 20040147738
    Abstract: The invention concerns a process for extracting hemicellulose from fiber, such as corn fiber. The process comprises agitating at least fiber, caustic and optional added water at a moisture content from about 10% to about 60% at high speeds in a highly fluidized state. The process substantially instantaneously extracts the hemicellulose from the fiber. Heat may be applied in the process to extract and dry the hemicellulose substantially simultaneously.
    Type: Application
    Filed: January 24, 2003
    Publication date: July 29, 2004
    Inventor: Roman Skuratowicz
  • Publication number: 20040121436
    Abstract: Ethanol is produced from biomass by the process of a heated aqueous solution containing 20 to 40 percent alkali metal hydroxide to break the lignin-cellulose bond. Then the biomass is heated further to remove carbon dioxide from the cellulose and lignin to produce a mixture of carbohydrates, modified sodium lignin, micro-cellulose, lignin-cellulose resinous products and sodium carbonate. Water is added to the mixture and most of the mixture is water soluble. An acidic salt forming compound is added to the aqueous solution until a pH of 3-7 is obtained. The lignin is precipitated. The lignin-cellulose resinous products float to the top and is skimmed off. The solution containing the carbohydrates and salt is decanted off the lignin and is concentrated by evaporating off water. The carbohydrates crystalizes from the solution and the water and salt is filtered off. Water is added to the carbohydrates then it is fermented to form ethanol. The ethanol is recovered from the water by evaporation.
    Type: Application
    Filed: January 5, 2001
    Publication date: June 24, 2004
    Inventor: David H. Blount
  • Publication number: 20040096948
    Abstract: An ammonium-based &bgr;-elimination cleavage of linked oligosaccharides from glycoproteins is described. The method enables the isolation of glycoprotein-derived oligosaccharides having a reducing end which enables subsequent derivatization for chromatographic and/or mass spectral analysis. The described glycoprotein cleavage protocol enables structural investigations using low microgram quantities of glycoproteins.
    Type: Application
    Filed: August 19, 2003
    Publication date: May 20, 2004
    Inventors: Yunping Huang, Yehia S. Mechref, Milos V. Novotny
  • Publication number: 20040097464
    Abstract: The present invention relates to a mixture of non-sulfated fucose-based oligosaccharides, characterized in that it comprises oligosaccharides of less than 13 saccharide units, comprising at least one fucose unit in a non-reducing end position, and in that at least it is capable of being obtained by means of a process that comprises at least one step of degradation of a polysaccharide from a microorganism of the gender Klebsiella pneumoiae subsp. pneumoniae. This new mixture presents significant activities on different components of the skin, providing a clearly visible anti-aging result, specially by an excellent thickening of the skin.
    Type: Application
    Filed: June 23, 2003
    Publication date: May 20, 2004
    Inventors: Ladislas Robert, Alexandre Michel Robert, Catherine Sylvie Robert, Jean-Luc Gesztesi
  • Publication number: 20040094145
    Abstract: The invention relates to a method for producing microspherical crystallites with a uniform spherical shape and an extremely narrow size distribution. Said crystallites consist wholly or partially of a linear water-insoluble polysaccharide, preferably of 1,4-&agr;-D-polyglucane, have a degree of crystallinity of >80% and can contain additional polymers and/or active ingredients, which are in particular biodegradable. They are particularly suitable for the controlled release of active ingredients. They are produced by fusing 1,4-&agr;-D-polyglucane or the polysaccharide in water, introducing the fusion into a precipitant, cooling the mixture and separating the particles that have formed.
    Type: Application
    Filed: January 8, 2004
    Publication date: May 20, 2004
    Inventors: Stephan Hausmanns, Thomas Kiy, Ivan Tomka, Rolf Muller, Peter Mertins
  • Publication number: 20040086514
    Abstract: Helicobacter pylori-binding substances comprising Gal&bgr;3GlcNAc or Gal&bgr;3GalNAc are described, as well as use thereof in pharmaceutical compositions and food-stuff, and methods for treatment of conditions due to the presence of Helicobacter pylori. Also use of said substance for the identification of bacterial adhesions, for the production of a vaccine against Helicobacter pylori, for diagnosis of Helicobacter pylori infections, for typing of Helicobacter pylori, for identification of Helicobacter pylori binding substances and for inhibition of the binding of Helicobacter pylori is described.
    Type: Application
    Filed: June 14, 2002
    Publication date: May 6, 2004
    Inventors: Karl-Anders Karlsson, Irene Leonardsson, Susann Teneberg, Jonas Angstrom
  • Publication number: 20040086981
    Abstract: The present invention relates to a method for efficiently producing oligosaccharide for use in pharmaceutical drugs, medicals, glyco chips and the like from cells, said method comprising giving saccharide primers to human cells, plant cells, or yeast, or giving saccharide primers to cells cultured using a high-density culture method.
    Type: Application
    Filed: September 11, 2003
    Publication date: May 6, 2004
    Inventors: Toshinori Sato, Emiko Sano
  • Publication number: 20040086902
    Abstract: The present invention relates to nucleic acids encoding modified polypeptides with fructosyl transferase activity, vectors containing this nucleic acid for the expression of the modified fructosyl transferase in prokaryotic or eukaryotic cells, host cells and/or transgenic plants containing these vectors, methods for producing high-molecular polyfructans with primarily &bgr;-1,2 bonds and a very low degree of branching, in particular inulin, method for producing fructooligosaccharides using the inulin produced according to the invention or using saccharose, as well as methods for producing difructose dianhydrides using the inulin produced according to the invention or using saccharose, as well as the use of the inulin produced according to the invention for the production of inulin ethers and inulin esters, and the use of fructooligosaccharides or hydrogenated fructooligosaccharides and difructose dianhydrides as a food additive, in particular as a dietetic food.
    Type: Application
    Filed: December 8, 2003
    Publication date: May 6, 2004
    Inventors: Dirk Engels, Alireza Haji Begli, Markwart Kunz, Ralf Mattes, Mohammad Munir, Manfred Vogel
  • Publication number: 20040076811
    Abstract: A process for producing a polysaccharide sponge comprises the steps of (A) freezing a photoreactive polysaccharide solution, and (B) irradiating the frozen photoreactive polysaccharide solution with light to crosslink the photoreactive polysaccharide, thereby obtaining the polysaccharide sponge. The process includes simplified steps requiring no removal of solvent, and has such an advantage that impurities are easily removed therefrom.
    Type: Application
    Filed: October 15, 2003
    Publication date: April 22, 2004
    Inventor: Tomoya Sato
  • Publication number: 20040077056
    Abstract: The present invention is directed to a Sphingomonas bacteria and a method of producing exopolysaccharides by culturing a Shingomonas bacteria in a fermentation broth for a time and temperature effective for providing a sphingan exopolysaccharide in a slime form.
    Type: Application
    Filed: July 10, 2003
    Publication date: April 22, 2004
    Applicants: Shin-Etsu Bio, Inc., Shin-Etsu Chemical Co., Ltd.
    Inventors: Motohide Yamazaki, Marcia Mikolajczak, Thomas J. Pollock, Richard W. Armentrout
  • Publication number: 20040073975
    Abstract: This invention includes a recombinant DNA molecule comprising a sequence for a fructosyltransferase capable of producing a novel fructan, a method for producing transgenic plants exhibiting a novel fructan, transformed plants and plant parts comprising said novel fructan, and products prepared therefrom.
    Type: Application
    Filed: August 20, 2003
    Publication date: April 15, 2004
    Inventor: Johan M. Stoop
  • Publication number: 20040067569
    Abstract: The present invention relates to isolated polypeptides having Family 74 xyloglucanase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Application
    Filed: April 18, 2003
    Publication date: April 8, 2004
    Applicant: Novozymes Biotech, Inc.
    Inventors: Michael W. Rey, Elizabeth J. Zaretsky, Jeffrey A. Haas
  • Publication number: 20040068108
    Abstract: Synthetic polysaccharides are disclosed containing 8-24 monosaccharide units made up of a concatenation of disaccharides consisting of a uronic acid and a hexose, wherein the hydroxyl groups of the polysaccharides are etherified with a C1-6 alkyl group or esterified in the form of a sulpho group, each disaccharide being at least monoetherified; and salts thereof, are disclosed.
    Type: Application
    Filed: October 2, 2003
    Publication date: April 8, 2004
    Inventors: Philippe Duchaussoy, Jean Marc Herbert, Guy Jaurand, Maurice Petitou, Constant Van Boeckel
  • Publication number: 20040068106
    Abstract: There are described novel cross-linked polymers based on bis-silane, bis-thioether, bis-sulphoxide, bis-sulphone and butane-di-yl derivatives of polysaccharides and oligosaccharides, their shaping as support materials useful for the separation or preparation of enantiomers; a process for preparing the said cross-linked polymer compounds, a process for preparing balls of support materials containing the said cross-linked polymer compounds; a method of obtaining balls of support materials useful in chromatography or in organic synthesis; and the use of the said support materials containing the cross-linked polymer compounds in separation or in preparation of enantiomers, through employment in chromatography or organic synthesis processes in a heterogeneous medium; and the use of the said cross-linked polymer compounds in the form of membranes in processes using percolation through membranes for the separation or the preparation of enantiomers.
    Type: Application
    Filed: October 29, 2003
    Publication date: April 8, 2004
    Inventor: Raphael Duval
  • Publication number: 20040064852
    Abstract: The present invention is in the field of fructan producing plants. Furthermore the present invention is directed to the production of at least 3 degree of polymermization. Additionally, the present invention is more specifically directed to non fructan producing plant which are transformed or crossed to contain at least two genes of the three fructosyltransferase.
    Type: Application
    Filed: September 22, 2003
    Publication date: April 1, 2004
    Inventors: Guy Weyens, Jean Lathouwers, Cornelius (Kees) Van Dun
  • Publication number: 20040058418
    Abstract: According to the present invention, &agr;1,2-fucosyltransferase can be expressed in a large amount by using Escherichia coli. Also, a fucose-containing complex carbohydrate can be economically produced in a large amount by contacting the Escherichia coli expressing the &agr;1,2-fucosyltransferase and a microorganism capable of producing GDP-fucose from a sugar and GTP, a microorganism capable of producing GTP from a precursor and an acceptor complex carbohydrate in an aqueous medium.
    Type: Application
    Filed: March 6, 2003
    Publication date: March 25, 2004
    Inventors: Tetsuo Endo, Satoshi Koizumi
  • Publication number: 20040059097
    Abstract: Disclosed are modified naturally occurring biocompatible biopolymers of plant and animal origin made by subjecting same to ionizing radiation in the presence of a mediating gas, typically acetylene to enable one to selectively enhance and modify one or more of the physiochemical properties of the starting materials which have a wide range of uses in medicine, food technology and other industrial applications. Notwithstanding the modifications, the biocompatibility of the biopolymer remains unchanged and no new or additional functional groups are introduced into the starting biopolymer.
    Type: Application
    Filed: March 28, 2003
    Publication date: March 25, 2004
    Inventors: Glyn Owen Phillips, Tjaart Andries Du Plessis, Saphwan Al-Assaf, Peter Anthony Williams
  • Publication number: 20040058016
    Abstract: A pharmaceutical composition and health care food comprise a lower alcohol-insoluble extract of Hovenia dulcis var. Koreana NAKAI or a polysaccharide isolated therefrom having a potent hepatoprotective activity.
    Type: Application
    Filed: July 31, 2003
    Publication date: March 25, 2004
    Inventors: Chun-Soo Na, Nam-Chul Jung
  • Patent number: 6709845
    Abstract: A modified S7 polysaccharide is disclosed. The polysaccharide contains 20% less glucose that S7. An S7c6 gene cluster is disclosed. A mutated Sphingomonas is also disclosed.
    Type: Grant
    Filed: June 30, 2000
    Date of Patent: March 23, 2004
    Assignees: Shin-Etsu Bio, Inc., Shin-Etsu Chemical Co., Ltd
    Inventor: Thomas J. Pollock
  • Patent number: 6706291
    Abstract: To provide a producibility improver for poultry, comprising a polymannose having a molecular weight distribution in which a polymannose having the molecular weights ranging from 1.8×103 to 1.8×105 accounts for 70% or more; the producibility improver for poultry further comprising a polyphenol compound; the producibility improver for poultry further comprising a delipidated rice bran; and a method of improving producibility for laying hens or edible chicken, using any one of the producibility improvers. According to the present invention, the improvement of producibility for poultry can be made at low costs.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: March 16, 2004
    Assignee: Taiyo Kagaku Co., Ltd.
    Inventors: Noriyuki Ishihara, Tsutomu Okubo, Seiji Shu, Lekh Raj Juneja
  • Publication number: 20040043388
    Abstract: The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds.
    Type: Application
    Filed: September 3, 2002
    Publication date: March 4, 2004
    Inventors: Jon H. Come, Frank Becker, Nikolai A. Kley, Christoph Reichel
  • Publication number: 20040038303
    Abstract: Certain aspects of the invention relate to the use of small particles in biological systems, including the delivery of biologically active agents to cells or tissues using nanoparticles of less than about 200 nm in approximate diameter. Embodiments include collection of particles having a bioactive component, a surfactant molecule, a biocompatible polymer, and a cell recognition component, wherein the cell recognition component has a binding affinity for a cell recognition target. Compositions and methods of use are also set forth.
    Type: Application
    Filed: February 28, 2003
    Publication date: February 26, 2004
    Inventor: Gretchen M. Unger
  • Publication number: 20040039192
    Abstract: The present invention provides a method of recovering O-linked oligosaccharides from a macromolecule, the method comprising the steps: exposing the macromolecule to an alkaline agent to release O-linked olisaccharides from the macromolecule; separating the released oligosaccharide from the macromolecule; and recovering the oligosaccharide.
    Type: Application
    Filed: July 28, 2003
    Publication date: February 26, 2004
    Inventors: Nicolle Hannah Packer, Niclas Karlsson
  • Publication number: 20040038367
    Abstract: The present invention provides a novel xyloglucan oligosaccharide-degrading enzyme having a different degradation mechanism from known enzymes. This enzyme specifically cleaves the second &bgr;-glucoside linkage, counted from the reducing end among the &bgr;-glucoside linkage constituting the principal chain of xyloglucan oligosaccharide. In the present invention, the enzyme is collected from microorganisms belonging to Geotrichum species, and the amino acid and base sequences of the enzyme and polynucleotide encoding the enzyme are determined. Thus, high-purity polypeptides having the xyloglucan oligosaccharide-degradation activity can be prepared at low cost through a genetic engineering process.
    Type: Application
    Filed: March 25, 2003
    Publication date: February 26, 2004
    Inventors: Katsuro Yaoi, Yasushi Mitsuishi
  • Publication number: 20040038931
    Abstract: A complex, water soluble polysaccharide fraction having potent immunostimulatory activity isolated from Aloe vera. The polysaccharide fraction has an apparent molecular weight above 2 million daltons. Its major glycosyl components are glucose, galactose, mannose and arabinose. The invention further includes pharmaceutical compositions containing the instant polysaccharide fraction, optionally in combination with acceptable pharmaceutical carriers and/or excipents. These pharmaceutical compositions may be used to provide immunostimulation to an individual in need of such treatment by administering to such an individual an effective amount of the composition. The polysaccharide fraction is also useful as a component of dietary supplements and as a standardization component of commercial Aloe products.
    Type: Application
    Filed: August 13, 2003
    Publication date: February 26, 2004
    Inventors: Mahmoud Elsobly, Samir Ross, David Stanley Pasco, Nirmal Derek Pugh
  • Publication number: 20040039193
    Abstract: A method for the manufacture of a solid porous separation material based on a polysaccharide, said method comprising the steps of: (a) providing an aqueous solution (I) of a polysaccharide, (b) solidifying the solution, preferably by transforming the solution to a gel, and (c) optionally cross-linking the polysaccharide, with the proviso that, if step (c) is present, steps (b) and (c) may be carried out simultancously. The method is characterised in that the polysaccharide provided in step (a) is modified by being inter-molecularly cross-linked to an extent such that the viscosity of solution (I) is at least 110%, preferably at least 200%, of the viscosity of an aqueous solution (II) of the corresponding polysacchaiide which has not been inter-molecularly cross-linked and which is present in the same concentration as the inter-molecularly cross-linked polysaccharide is in solution (I).
    Type: Application
    Filed: June 19, 2003
    Publication date: February 26, 2004
    Inventors: Hans Berg, Mats Carlsson
  • Patent number: 6691783
    Abstract: A novel microorganism producing a nontoxic, non-antigenic exopolysaccharide is taught. The exopolysaccharide has neutral sugars migrating at the same rate as mannose, fucose, fructose and galactose, acidic sugars migrating at the same rate as fucose and amine sugars migrating at the same rate as glucose and fucose, and wherein the ratio of galactose:fucose:glucose:mannose is about 1:2:3:6. The microbe and the exopolysaccharide have uses as a biofilm in geologic applications and have several consumer uses as food and drug polymers and use as a plasma extender.
    Type: Grant
    Filed: October 25, 2000
    Date of Patent: February 17, 2004
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Lee A. Bulla, Jr., John P. Turner
  • Patent number: 6689378
    Abstract: Methods of immobilizing uncomplexed and complexed cyclodextrins to cellulose fibers and compositions including cyclodextrin immobilized to cellulose fibers are provided. The cyclodextrins are immobilized using a crosslinking means that covalently bonds the cyclodextrin to the substrate, without the cyclodextrin being derivatized. The compositions can be used in all types of cellulose fiber containing articles, such as tissues and personal care articles, for odor absorbency or for release of complexed molecules.
    Type: Grant
    Filed: December 28, 1999
    Date of Patent: February 10, 2004
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Tong Sun, Jeffrey D. Lindsay
  • Publication number: 20040022782
    Abstract: The application relates to the purification and characterisation of a family of P-type inositolphosphoglycans (IPGs) from human liver and placenta. These substances are shown to have P-type biological activity, e.g. activating pyruvate dehydrogenase (PDH) phosphatase. The characterisation of the compounds demonstrates that they contain metal ions, in particular Mn2+ and/or Zn2+, and optionally phosphate. The compounds and their antagonists have uses as pharmaceuticals, e.g. for the treatment of diabetes, and in screening for synthetic analogues.
    Type: Application
    Filed: June 18, 2003
    Publication date: February 5, 2004
    Applicant: Rodaris Pharmaceuticals Limited
    Inventors: Thomas William Rademacher, Hugo Caro
  • Publication number: 20040024199
    Abstract: The present invention relates to a polysaccharide of Echinacea angustifolia roots, having molecular weight of 1.3×105 Da and consisting of rhamnose, arabinose, galactose and galacturonic acid in ratio 0.5:2.5:1.75:10.25.
    Type: Application
    Filed: November 25, 2002
    Publication date: February 5, 2004
    Inventors: Andrea Giori, Alessandro Anelli, Paolo Morazzoni, Francesco Di Pierro
  • Publication number: 20040022784
    Abstract: Material characterized by that the material contains at least one biologically active saccharide which is covalently bound via at least one spacer to a cross-linked matrix and that the material is autoclaved.
    Type: Application
    Filed: June 12, 2003
    Publication date: February 5, 2004
    Inventor: Kurt Nilsson
  • Publication number: 20040014961
    Abstract: The invention relates to soluble highly branched glucose polymers having a reducing sugar content of less than 1%, characterized in that they have a level of &agr;-1,6 glucoside bonds greater than 10%, preferably of between 12 and 30%, a Mw value of between 0.35×105 and 2×105 daltons, and an osmolality having a value of between 1 and 15 mOsm/kg. The invention also relates to their method of production and their applications in the Paper-Carton, Textiles, Cosmetics, and particularly Pharmaceutical and Food industries, and still more particularly in the fields of enteral and parenteral nutrition, peritoneal dialysis as a glycemia inhibiting and/or regulating agent, as an energy source during physical activities and as a digestion regulating agent.
    Type: Application
    Filed: June 4, 2003
    Publication date: January 22, 2004
    Inventors: Daniel Backer, Marie-Helene Saniez
  • Publication number: 20040014716
    Abstract: The invention is concerned with film-forming compositions containing hydrolysates of the exopolysaccharide YAS34 for the use in pharmaceutical, veterinary, food, cosmetic or other products like films for wrapping foods, aspices or jellies, preferably for predosed formulations like soft or hard capsules.
    Type: Application
    Filed: February 6, 2003
    Publication date: January 22, 2004
    Inventors: Robert Anthony Scott, Dominique Cade, Xiongwei He
  • Publication number: 20040014092
    Abstract: Nucleic acid molecules are described encoding proteins with the enzymatic activity of a fructosyl transferase. These enzymes are fructosyl transferases (FFT). Moreover, vectors and host cells are described containing the nucleic acid molecules of the invention, in particular transformed plant cells, plant tissue and plants regenerable therefrom, which express the described FFT. Furthermore, methods for the production of long-chain inulin by using the described proteins, hosts, in particular the plant cells and/or FFT produced by them, are described.
    Type: Application
    Filed: March 13, 2003
    Publication date: January 22, 2004
    Applicant: Max-Planck-Gesellschaft Zur Forderung der Wissenschaften e.V.
    Inventors: Arnd G. Heyer, Elke Hellwege, Dominique Gritscher