Encodes An Enzyme Patents (Class 536/23.2)
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Publication number: 20120065251Abstract: The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which is a toxin. The constructs of the invention are particularly useful for treating tumors expressing miR-21.Type: ApplicationFiled: January 19, 2010Publication date: March 15, 2012Inventors: Rina Rosin-Arbesfeld, Ella Sklan, Alona Zilberberg, Naama David
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Publication number: 20120064568Abstract: The present invention generally relates to methods of modifying the glycosylation structures of recombinant proteins expressed in fungi or other lower eukaryotes, to more closely resemble the glycosylation of proteins from higher mammals, in particular humans. The present invention also relates to novel enzymes and, nucleic acids encoding them and, hosts engineered to express the enzymes, methods for producing modified glycoproteins in hosts and modified glycoproteins so produced.Type: ApplicationFiled: March 24, 2011Publication date: March 15, 2012Applicant: Glycofi, Inc.Inventor: Stephen Hamilton
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Publication number: 20120064598Abstract: The invention concerns nucleic acids coding for mutated or truncated forms of the human parkin gene, or forms comprising multiplication of exons, and the corresponding proteins and antibodies. The invention also concerns methods and kits for identifying mutations of the parkin gene, and for studying compounds for therapeutic purposes.Type: ApplicationFiled: August 15, 2011Publication date: March 15, 2012Applicants: INSTITUT NATIONAL SANTE ET RECHERCHE MEDICALE, AVENTIS PHARMA S.A.Inventors: Alexis Brice, Christophe Lucking, Patrice Denefle, Sylvain Ricard, Nacer Eddine Abbas, Sandrine Bouley
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Patent number: 8133715Abstract: The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In various aspects of the invention, the recombinant microorganisms may further comprise one or more modifications resulting in the reduction or elimination of 3 keto-acid (e.g., acetolactate and 2-aceto-2-hydroxybutyrate) and/or aldehyde-derived by-products. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.Type: GrantFiled: March 29, 2011Date of Patent: March 13, 2012Assignee: Gevo, Inc.Inventors: Thomas Buelter, Andrew Hawkins, Stephanie Porter-Scheinman, Peter Meinhold, Catherine Asleson Dundon, Aristos Aristidou, Jun Urano, Matthew Peters, Melissa Dey, Justas Jancauskas, Julie Kelly, Ruth Berry
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Patent number: 8133704Abstract: Aspects of the invention relate to methods for the production of difunctional alkanes in host cells. In particular, aspects of the invention describe components of genes associated with the difunctional alkane production from carbohydrate feedstocks in host cells. More specifically, aspects of the invention describe metabolic pathways for the production of adipic acid, aminocaproic acid, caprolactam, and hexamethylenediamine via 2-ketopimelic acid.Type: GrantFiled: March 18, 2011Date of Patent: March 13, 2012Assignee: Celexion, LLCInventors: Brian M. Baynes, John Michael Geremia
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Patent number: 8133711Abstract: The present invention provides BGL7 polypeptides with the biological activity of a ?-glucosidase and a method of producing a recombinant enzyme having ?-glucosidase activity.Type: GrantFiled: June 24, 2008Date of Patent: March 13, 2012Assignee: Danisco US Inc.Inventors: Nigel Dunn-Coleman, Michael Ward
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Patent number: 8133705Abstract: The invention relates to a novel aminotransferase, DNA encoding the enzyme, a recombinant vector into which the DNA has been introduced, and a transformant into which the vector has been introduced. Further, the invention also relates to a method for producing an optically active amino compound utilizing the enzyme or transformant. The aminotransferase of the invention has an ability of efficiently converting a ketone compound, particularly a cyclic ketone compound to an optically active amino compound. According to the invention, a method for efficiently producing an optically active amino compound, particularly an optically active cyclic amino compound is provided.Type: GrantFiled: May 22, 2006Date of Patent: March 13, 2012Assignee: Kaneka CorporationInventors: Noriyuki Ito, Yoshihiko Yasohara
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Publication number: 20120060235Abstract: Disclosed herein are nucleic acid molecules isolated from coffee (Coffea spp.) comprising sequences that encodes various sucrose metabolizing enzymes, along with their encoded proteins. Specifically, sucrose synthase, sucrose phosphate synthase and sucrose phosphatase enzymes and their encoding polynucleotides from coffee are disclosed. Also disclosed are methods for using these polynucleotides for gene regulation and manipulation of the sugar profile of coffee plants, to influence flavor, aroma, and other features of coffee beans.Type: ApplicationFiled: July 13, 2011Publication date: March 8, 2012Inventors: Isabelle M. PRIVAT, James Gérard McCarthy, Vincent Petiard, Steven D. Tanksley, Chenwei Lin
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Publication number: 20120058532Abstract: The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The invention further provides ketol-acid reductoisomerase enzymes which have been mutated or modified to increase their NADH-dependent activity or to switch the cofactor preference from NADPH to NADH and are expressed in the modified microorganisms. In addition, the invention provides isobutyraldehyde dehydrogenase enzymes expressed in modified microorganisms. Also provided are methods of producing beneficial metabolites under aerobic and anaerobic conditions by contacting a suitable substrate with the modified microorganisms of the present invention.Type: ApplicationFiled: October 11, 2011Publication date: March 8, 2012Applicants: California Institute of Technology, Gevo, Inc.Inventors: Thomas Buelter, Peter Meinhold, Reid M. Renny Feldman, Andrew Hawkins, Sabine Bastian, Frances Arnold, Jun Urano
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Publication number: 20120060243Abstract: The invention provides transgenic or non-transgenic plants with improved levels of tolerance to AHAS-inhibiting herbicides. The invention also provides nucleic acids encoding mutants of the acetohydroxyacid synthase (AHAS) large subunit, expression vectors, plants comprising the nucleic acids encoding the AHASL subunits containing one, two, or more mutations, plants comprising such AHASL subunit mutant nucleic acids, methods for making and using the same, and methods of controlling weeds.Type: ApplicationFiled: September 24, 2009Publication date: March 8, 2012Inventors: Peter Beetham, Dale Carlson, Greg Gocal, John McElver, James Pearce, Christian Schopke, Bijay Singh, Keith Walker
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Publication number: 20120058928Abstract: An alkaline protease variant derived from an alkaline protease consisting of an amino acid sequence represented by SEQ ID NO: 2 or consisting of an amino acid sequence having an identity of 90% or more therewith, which variant has mutations wherein one or more amino acid residues at positions selected from (a) position 6, (b) position 15, (c) position 16, (d) position 65, (e) position 66, (f) position 82, (g) position 83, (h) position 204, (i) position 319, and (j) position 337 of the amino acid sequence represented by SEQ ID NO: 2, or at positions corresponding thereto are substituted with the following amino acid residues: (a) or a position corresponding thereto: Typ, Leu, Val, Ile, Met, Tyr, Gln, Lys, Thr, Phe, Arg, Ser, Cys, Ala, or His; (b) or a position corresponding thereto: Glu, Met, Asp, Val, Gln, Arg, Cys, Trp, Ala, or Phe; (c) or a position corresponding thereto: Met, Glu, Arg, Val, Lys, Phe, Tyr, Ile, His, Asp, or Cys; (d) or a position corresponding thereto: Trp; (e) or a position corresponding tType: ApplicationFiled: April 26, 2010Publication date: March 8, 2012Applicant: Kao CorporationInventors: Masatoshi Tohata, Mitsuyoshi Okuda, Tsuyoshi Sato, Keiji Endo, Katsuhisa Saeki
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Publication number: 20120058244Abstract: Compositions and methods are provided for modulating the level of phytate in plants. More specifically, the invention relates to methods of modulating the level of phytate utilizing nucleic acids comprising multidrug resistance-associated protein (MRP) nucleotide sequences to modulate the expression of MRP(s) in a plant of interest. The compositions and methods of the invention find use in agriculture for improving the nutritional quality of food and feed by reducing the levels of phytate and/or increasing the levels of non-phytate phosphorus in food and feed. The invention also finds use in reducing the environmental impact of animal waste.Type: ApplicationFiled: November 11, 2011Publication date: March 8, 2012Applicants: E.I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.Inventors: JINRUI SHI, DAVID ERTL, HONGYU WANG, BAILIN LI, MARIANNA FALLER, KATHLEEN SCHELLIN
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Publication number: 20120060242Abstract: The present invention pertains to the recombinant manufacture of polyunsaturated fatty acids. Specifically, it relates to acyltransferase polypeptides, polynucleotides encoding said acyltransferases as well as vectors, host cells, non-human transgenic organisms containing said polynucleotides. Moreover, the present invention contemplates methods for the manufacture of polyunsaturated fatty acids as well as oils obtained by such methods.Type: ApplicationFiled: May 11, 2010Publication date: March 8, 2012Applicant: BASF PLANT SCIENCE COMPANY GMBHInventors: Toralf Senger, Sten Stymne, Jenny Lindberg Yilmaz
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Publication number: 20120058223Abstract: A novel cold-active beta-galactosidase is enzyme specific for lactose. The enzyme is thus useful in e.g. the food industry for catalyzing at low temperatures the hydrolysis of lactose disaccharide into its constituent monosaccharides, glucose and galactose. A method produces the cold-active beta-galactosidase by recombinant DNA technology.Type: ApplicationFiled: February 9, 2010Publication date: March 8, 2012Applicant: Kobenhavns UniversitetInventors: Peter Stougaard, Mariane Schmidt
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Patent number: 8129511Abstract: This invention relates to nucleic acids encoding amylase polypeptides, the encoded polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial qualities. Specifically, the amylases of the current invention show an altered exo-specificity and/or thermostability. Some embodiments of the invention relate to said polypeptides and nucleic acids and their uses as non-maltogenic exoamylases in producing food products.Type: GrantFiled: February 8, 2011Date of Patent: March 6, 2012Assignee: Danisco A/SInventors: Karsten Matthias Kragh, Bo Spange Sørensen, Casper Tune Berg, Kirsten Bojsen, Patrick M. F. Derkx, Carol Fioresi, Anja H. Kellett-Smith, Charlotte Refdahl Thoudahl, Oene R. Veltman, Gijsbert Gerritse, Wei Liu, Andrew Shaw
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Patent number: 8128940Abstract: The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain; polynucleotide molecules encoding such modified Clostridial toxins; and method of producing such modified Clostridial toxins.Type: GrantFiled: March 14, 2006Date of Patent: March 6, 2012Assignee: Allergan, Inc.Inventors: Lance E. Steward, Ester Fernandez-Salas, Joseph Francis, Shengwen Li, Marcella A. Gilmore, Kei R. Aoki
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Patent number: 8129591Abstract: The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: April 22, 2010Date of Patent: March 6, 2012Assignee: Novozymes, Inc.Inventors: Kimberly Brown, Michelle Maranta, Eric Abbate
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Patent number: 8129170Abstract: Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct: a nucleotide sequence from Pseudomonas fluorescens Pf5 (ATCC® BAA-477) encoding a polypeptide having sucrose transporter activity and a nucleotide sequence from Pseudomonas fluorescens Pf5 (ATCC® BAA-477) encoding a polypeptide having sucrose hydrolase activity. These nucleotide sequences are each operably linked to the same or a different promoter. Recombinant bacteria capable of metabolizing sucrose to produce glycerol and/or glycerol-derived products such as 1,3-propanediol and 3-hydroxypropionic acid are also described.Type: GrantFiled: December 6, 2010Date of Patent: March 6, 2012Assignee: E.I. du Pont de Nemours and CompanyInventor: Tina K. Van Dyk
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Patent number: 8129590Abstract: The present invention relates to isolated polypeptides having acetylxylan esterase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: GrantFiled: December 3, 2008Date of Patent: March 6, 2012Assignee: Novozymes A/SInventors: Michelle Maranta, Kimberly Brown
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Patent number: 8129160Abstract: Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.Type: GrantFiled: July 2, 2009Date of Patent: March 6, 2012Assignee: Probiodrug AGInventors: Stephan Schilling, Holger Cynis, Jens-Ulrich Rahfeld, Hans-Ulrich Demuth
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Patent number: 8129162Abstract: Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NADH are described.Type: GrantFiled: December 18, 2008Date of Patent: March 6, 2012Assignee: Butamax(TM) Advanced Biofuels LLCInventors: Yougen Li, Der-Ing Liao, Mark J. Nelson, Daniel P. Okeefe
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Patent number: 8129163Abstract: An object of the present invention is to provide a novel alcohol dehydrogenase, a gene for the alcohol dehydrogenase, a vector including the gene, a transformant transformed with the vector, and a method for producing an optically active alcohol by utilizing them. A feature of the present invention directs to a novel polypeptide isolated from Candida maltosa, a DNA coding for the polypeptide, and a transformant producing the polypeptide. Another feature of the present invention directs to a method for producing an optically-active alcohol by reducing a carbonyl compound with the polypeptide or the transformant.Type: GrantFiled: November 27, 2007Date of Patent: March 6, 2012Assignee: Kaneka CorporationInventors: Shigeru Kawano, Takeru Ishige, Keita Iguchi, Tozo Nishiyama, Yoshihiko Yasohara
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Patent number: 8129180Abstract: The present invention relates to an enzyme determining amino acid sequences of an enzyme involved in pyrethrin biosynthesis and a base sequence of the gene thereof; constructing vectors bearing the gene and transformants; and extractable from plant bodies producing pyrethrin by applying such creative techniques to plant bodies with faster growth aiming to provide a method to efficiently produce pyrethrin; and the enzyme is a gene encoding a protein of the following (i) or (ii): (i) a protein consisting of an amino acid sequence shown in Sequence No. 1; or (ii) a protein consisting of an amino acid sequence including one or more of a substitution, deletion, insertion, and/or addition of amino acid in the amino acid sequence shown in Sequence No. 1, in which the protein exhibits activity of pyrethrin biosynthetic enzyme.Type: GrantFiled: June 3, 2009Date of Patent: March 6, 2012Assignees: An Educational Foundation Kinki University, Dainihon Jochugiku Co., Ltd.Inventors: Kazuhiko Matsuda, Yukio Kikuta
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Publication number: 20120052549Abstract: Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3] to eicosapentaenoic acid [EPA; 20:5 omega-3] and possessing at least one mutation within the HPGG (SEQ ID NO:7) motif of the cytochome b5-like domain and at least one mutation within the HDASH (SEQ ID NO:8) motif are disclosed. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-5 desaturases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”], are also disclosed.Type: ApplicationFiled: August 26, 2011Publication date: March 1, 2012Applicant: E. I. DU PONT DE NEMOURS AND COMPANYInventors: Melissa D. Bosak, Michael W. Bostick, Hongxian He, Seung-Pyo Hong, Dana M. Walters Pollak, Pamela L. Sharpe, Yehong Jamie Wang, Zhixiong Xue, Narendra S. Yadav, Hongxiang Zhang, Quinn Qun Zhu
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Publication number: 20120054909Abstract: The invention relates to the isolation and characterization of a maize gene, RAMOSA3 (RA3), responsible for meristem development and inflorescence development including branching. The gene, gene product, and regulatory regions may be used to manipulate branching, meristem growth, inflorescence development and arrangement, and ultimately to improve yield of plants. The invention includes the gene and protein product as well as the use of the same for temporal and spatial expression in transgenic plants to alter plant morphology and affect yield in plants. The invention also includes the gene and protein product for SISTER OF RAMOSA3 (SRA).Type: ApplicationFiled: November 4, 2011Publication date: March 1, 2012Applicants: COLD SPRING HARBOR LABORATORY, E.I. DU PONT DE NEMOURS AND COMPANYInventors: DAVID PETER JACKSON, NAMIKO NAGASAWA, NOBUHIRO NAGASAWA, HAJIME SAKAI
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Publication number: 20120052546Abstract: The present invention relates to isolated Clostridium perfringens bacteriophage lytic enzymes from baccteriophages CP26F and CP39O, and uses in controlling Clostridium perfringens.Type: ApplicationFiled: September 1, 2010Publication date: March 1, 2012Applicant: The United State of America, as represented by the Secretary of AgricultureInventors: Bruce S. Seal, Gregory R. Siragusa, Ibn Mustafa A. Simmons, Johnna K. Garrish, David M. Donovan
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Publication number: 20120052533Abstract: The present invention relates to 4S-iota-carrageenan sulfatase and to the use thereof for partially or totally converting the iota-carrageenan into iota-/alpha-carrageenan or alpha-carrageenan. The invention also relates to the method for extracting said enzyme from a Pseudoalteromonas bacteria population or from red marine algae. Finally, the present invention relates to the use of 4S-iota-carrageenan sulfatase to prepare a texturizing agent containing alpha-carrageenan.Type: ApplicationFiled: April 22, 2010Publication date: March 1, 2012Inventors: Sabine Joncour Genicot, William Helbert
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Publication number: 20120052553Abstract: Novel protease variants derived from the DNA sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor DNA sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease. Such variant proteases have properties which are different from those of the precursor protease, such as altered wash performance. The substituted amino acid residue equivalent to positions 7, 23, 26, 28, 29, 30, 31, 47, 66, 69, 73, 82, 85, 88, 90, 92, 93, 105, 113, 139, 148, 149, 150, 151, 178, 200, 201, 231, 233, 267 and/or 273 of Bacillus amyloliquefaciens subtilisin.Type: ApplicationFiled: October 13, 2010Publication date: March 1, 2012Applicant: Danisco US Inc.Inventor: Ayrookaran J. Poulose
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Publication number: 20120052551Abstract: The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of Aspergillus niger.Type: ApplicationFiled: September 2, 2011Publication date: March 1, 2012Applicant: Danisco US Inc.Inventors: Benjamin S. Bower, Nigel Dunn-Coleman, Suzanne E. Lantz, Cherry Lin, Michael Ward
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Patent number: 8124381Abstract: A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorganisms that are useful for producing glucosamine and N-acetylglucosamine. In addition, methods of recovering N-acetylglucosamine that has been produced by a fermentation process, including methods that result in N-acetylglucosamine of high purity, are described. Also disclosed is a method to produce glucosamine from N-acetylglucosamine.Type: GrantFiled: December 19, 2007Date of Patent: February 28, 2012Assignee: Arkion Life SciencesInventors: Ming-De Deng, J. David Angerer, Don Cyron, Alan D. Grund, Thomas A. Jerrell, Jr., Candice Leanna, Owen Mathre, Reinhardt Rosson, Jeff Running, Dave Severson, Linsheng Song, Sarah Wassink
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Patent number: 8124840Abstract: Method for the inhibition of carbon flow in the glycolytic direction in a cell by increasing the intracellular availability of trehalose-6-phosphate.Type: GrantFiled: June 13, 2007Date of Patent: February 28, 2012Assignee: Syngenta Mogen B.V.Inventors: Oscar Johannes Maria Goddijn, Jan Pen, Josephus Christianus Maria Smeekens
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Patent number: 8124396Abstract: The formation of acrylamide during heat treatment in the production of a food product is reduced by treating the raw material with an enzyme before the heat treatment. The enzyme is capable of reacting on asparagine or glutamine (optionally substituted) as a substrate or is a laccase or a peroxidase.Type: GrantFiled: December 7, 2007Date of Patent: February 28, 2012Assignee: Novozymes A/SInventors: Gitte Budolfsen, Morten Tovborg Jensen, Hans Peter Heldt-Hansen, Mary Ann Stringer, Lene Lange
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Patent number: 8124842Abstract: The present invention relates to plant cells and plants having an increased content of N-acetylated glucosamine derivatives. Furthermore, the present invention relates to plant cells and plants which synthesize glucosaminoglycans. The present invention also provides processes for producing said plants and compositions comprising said plant cells.Type: GrantFiled: October 5, 2006Date of Patent: February 28, 2012Assignee: Bayer Cropscience AGInventors: Claus Frohberg, Bernd Essigmann
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Patent number: 8124749Abstract: The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or diagnostic potential.Type: GrantFiled: June 12, 2008Date of Patent: February 28, 2012Assignee: Case Western Reserve UniversityInventors: Stephen M. Selkirk, Robert H. Miller
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Patent number: 8124845Abstract: The present invention relates to plants, seeds and products derived thereof, in particular to Brassica plants, seeds products derived thereof, that have mutant sequences conferring high oleic acid profile on the seed oil. More particularly, the invention relates to mutant delta-12 fatty acid desaturase sequences, also referred to herein as FAD2 sequences, in such plants which confer high oleic acid profile on the seed oil.Type: GrantFiled: January 4, 2007Date of Patent: February 28, 2012Assignee: Monsanto S.A.S.Inventors: Jean-Pierre Despeghel, Christel Granier
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Patent number: 8124347Abstract: The present invention relates generally to hydrogen production for use in fuel cells, foodstuffs and chemical production, and more particularly, to biologically and photosynthetically produced hydrogen. Specifically, disclosed is a method for producing bacteria and green alga that can produce hydrogen in quantities that exceed four hundred percent of the hydrogen produced by green alga in nature; thus, producing organisms which can serve as hydrogen generators for fuel cells, chemical production and numerous other applications.Type: GrantFiled: April 23, 2009Date of Patent: February 28, 2012Inventors: Scott Plummer, Mark Plummer
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Patent number: 8124372Abstract: The present invention relates to a process for the amidation of C-terminal esters or acids of peptide substrates in solution-phase synthesis of peptides, comprising amidating one or more peptide substrates comprising C-terminal esters or acids using the protease subtilisin in any suitable form in the presence of an ammonium salt derived from an acid having a pKa above 0. This process is useful in the production of protected or unprotected peptides.Type: GrantFiled: June 24, 2008Date of Patent: February 28, 2012Assignee: N.V. OrganonInventors: Ivo Franci Eggen, Carmen Gabriela Boeriu
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Patent number: 8124846Abstract: The invention concerns a novel method for making herbicide-tolerant plants, in particular to HPPD inhibiting herbicides, the nucleic acid sequences coding for enzymes capable of being used in said method, expression cassettes containing them and transgenic plants comprising at least one of said expression cassettes.Type: GrantFiled: November 6, 2007Date of Patent: February 28, 2012Assignee: Bayer CropScience S.A.S.Inventors: Olivier Zink, Eric Paget, Anne Rolland, Alain Sailland, Georges Freyssinet
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Patent number: 8124388Abstract: Methods of using beta-alanine/pyruvate aminotransferase to produce 3-hydroxypropionic acid and derivatives thereof, from beta-alanine, are disclosed. Cells and recombinant nucleic acids that can be used to practice the methods are also disclosed.Type: GrantFiled: June 29, 2010Date of Patent: February 28, 2012Assignee: Novozymes A/SInventors: Hans H. Liao, Ravi R. Gokarn, Steven John Gort, Holly Jean Jessen, Olga V. Selifonova
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Publication number: 20120047604Abstract: An isolated nucleic acid molecule comprising a nucleotide sequence which encodes a polypeptide comprising both a steroidogenic acute regulatory protein-related lipid transfer (START) domain and a kinase domain is provided, as well as plant cells and transgenic plants comprising said nucleic acid molecule, said transgenic plants being resistant to plant disease.Type: ApplicationFiled: February 21, 2010Publication date: February 23, 2012Inventors: Jorge Dubcovsky, Tzion Fahima, Assaf Distelfeld, Cristobal Uauy, Ann E. Blechl, Daolin Fu
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Publication number: 20120047600Abstract: The invention provides methods for increasing lignin content in plants by expression of a cinnamoyl CoA reductase 2 (CCR2) coding sequence in the plant. Also provided are methods for reducing lignin content in a plant by down-regulation of CCR2 expression in the plant. Nucleic acid molecules for modulation of CCR2 expression and transgenic plants the same are also provided. Plants described herein may be used, for example, as improved biofuel feedstock and as highly digestible forage crops. Methods for processing plant tissue and for producing biofuels by utilizing such plants are also provided.Type: ApplicationFiled: July 12, 2011Publication date: February 23, 2012Inventors: Rui ZHOU, Richard A. DIXON, Fang CHEN
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Publication number: 20120045390Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.Type: ApplicationFiled: September 5, 2003Publication date: February 23, 2012Applicant: Genentech, Inc.Inventors: Frederic J. DeSauvage, William I. Wood, Zemin Zhang
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NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES
Publication number: 20120045777Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: June 27, 2011Publication date: February 23, 2012Applicant: Millennium Pharmaceuticals, Inc.Inventors: Christopher C. Fraser, Thomas M. Barnes, John D. Sharp, Susan J. Kirst, Paul S. Myers, Kevin R. Leiby, Douglas A. Holtzman, Sean A. McCarthy, Nicholas Wrighton, Charles R. Mackay, Andrew D.J. Goodearl -
Publication number: 20120045817Abstract: Described are compositions and methods relating to variant alpha-amylases having altered biochemical properties and advantageous performance characteristics as compared to a reference alpha-amylase. The variants are suitable for use in various industrial applications such as starch conversion, ethanol production, laundry, dishwashing, pulp and paper production, textile desizing, and/or sweetener production.Type: ApplicationFiled: April 1, 2010Publication date: February 23, 2012Inventors: David A. Estell, Brian E. Jones, Marc Kolkman, Christian D. Adams, Edward M. Concar
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Publication number: 20120045811Abstract: The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.Type: ApplicationFiled: November 1, 2011Publication date: February 23, 2012Applicant: Danisco US Inc.Inventors: Nigel Dunn-Coleman, Frits Goedegebuur, Michael Ward, Jian Yao
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Publication number: 20120045549Abstract: The present invention relates to an asparaginase having the width of the pH activity profile which is at least 3.5. Furthermore the invention relates to newly identified asparaginase polypeptide according to any one of SEQ ID NO: 2 or SEQ ID NO: 4 and to variants thereof and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the invention relates to the use of these novel asparaginase variants in industrial processes.Type: ApplicationFiled: August 29, 2011Publication date: February 23, 2012Inventors: Jan Metske Laan Van Der, Mark Cristiaan Stor, Ilse De Lange, Lisette Mohrmann
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Publication number: 20120045806Abstract: Polypeptide with an amino acid sequence according to SEQ ID No. 1 or a variant in which up to 10% of the amino acids have been altered by insertions, deletions or substitution.Type: ApplicationFiled: November 24, 2009Publication date: February 23, 2012Applicant: N-ZYME BIOTEC GMBHInventors: Holger Zorn, Marco Alexander Fraatz, Stephanie Johanna Luise Reimer, Meike Takenberg, Ulrich Krings, Ralf Günter Berger, Stefan Marx
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Publication number: 20120046339Abstract: The nucleotide sequence of a 992 bp region of cDNA and the nucleotide sequence of a 1973 bp (or a 1913 bp) of genomic DNA of the Gr-cm-1 gene were determined for G. rostochiensis. PCR primers and probes specific for G. rostochiensis and G. pallida were generated. PCR assays, including a real-time TaqMan PCR were used to identify G. rostochiensis and G. pallida and to differentiate G. rostochiensis from G. pallida. Transgenic hairy roots expressing Gr-cm-1 dsRNA were generated. There was a 52% reduction in the average number of females per root in the Gr-cm-1 dsRNA transgenic lines when compared with the infected control lines.Type: ApplicationFiled: July 24, 2009Publication date: February 23, 2012Inventors: Xiaohong Wang, Shunwen Lu
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Publication number: 20120047603Abstract: Isolated polynucleotides and polypeptides and recombinant DNA constructs useful for conferring drought tolerance, compositions (such as plants or seeds) comprising these recombinant DNA constructs, and methods utilizing these recombinant DNA constructs. The recombinant DNA construct comprises a polynucleotide operably linked to a promoter that is functional in a plant, wherein said polynucleotide encodes a Fatty Acid Desaturase Family (FADF) polypeptide.Type: ApplicationFiled: June 2, 2010Publication date: February 23, 2012Inventors: Stephen M. Allen, Stanley Luck, Jeffrey Mullen, Hajime Sakai, Scott V. Tingey, Robert Wayne Williams
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Publication number: 20120045813Abstract: According to the present invention, a protein having an ability to enhance a selenate reduction activity, a gene encoding it, and a method for selenate reduction using them are providedType: ApplicationFiled: October 5, 2009Publication date: February 23, 2012Inventors: Mitsuo Yamashita, Michihiko Ike