Encodes A Microbial Polypeptide Patents (Class 536/23.7)
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Patent number: 8658155Abstract: Methods and compositions for producing selected non-human mammalian germ cells and gametes and for making non-human animals using the produced germ cells and gametes are provided by the present invention. Methods of generating a non-human embryo and/or animal derived from donor stem cells, methods of generating chimeric non-human animals having substantially all gametes and/or germ cells derived from the donor stem cells, methods of producing a non-human host embryo lacking functional endogenous germ cells and non-human host embryos incapable of developing endogenous gametes of the present invention are described herein.Type: GrantFiled: December 27, 2011Date of Patent: February 25, 2014Assignee: The Jackson LaboratoryInventors: Michael V. Wiles, Robert Taft
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Publication number: 20140051829Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 3, or 4, the nucleotide sequence set forth in SEQ ID NO:1, 9, 10, or 11, as well as variants and fragments thereof.Type: ApplicationFiled: October 18, 2013Publication date: February 20, 2014Applicant: Athenix Corp.Inventors: Nalini Manoj Desai, Jill Hinson, Deepa Balasubramanian, Kimberly S. Sampson, Daniel J. Tomso, Duane Alan Lehtinen, Nicholas B. Duck, Rong Guo, Volker Heinrichs
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Patent number: 8652773Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: GrantFiled: September 12, 2012Date of Patent: February 18, 2014Assignee: Nationwide Children's Hospital, Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
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Publication number: 20140046049Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 3, or 4, the nucleotide sequence set forth in SEQ ID NO:1, 9, 10, or 11, as well as variants and fragments thereof.Type: ApplicationFiled: October 18, 2013Publication date: February 13, 2014Applicant: Athenix Corp.Inventors: Nalini Manoj Desai, Jill Hinson, Deepa Balasubramanian, Kimberly S. Sampson, Daniel J. Tomso, Duane Alan Lehtinen, Nicholas B. Duck, Rong Guo, Volker Heinrichs
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Publication number: 20140046048Abstract: A method for constructing a consensus sequence from a sequence alignment. The consensus sequence may be used to generate molecular standards that may substitute for genomic DNA in various assays. Since a molecular standard cannot have unresolved bases, the method removes less informative sequences to resolve all positions in the alignment. Also includes several sequences from pathogenic waterborne species that were constructed according to the method.Type: ApplicationFiled: June 28, 2013Publication date: February 13, 2014Applicant: Phthisis Diagnostics LLCInventors: Crystal R. Icenhour, Brian V. Loyal, Tyler Hartley, Linh Nguyen
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Publication number: 20140037554Abstract: The present invention discloses methods and materials for delivering a cargo compound into a cancer cell. Delivery of the cargo compound is accomplished by the use of protein transduction domains derived from cupredoxins. The invention further discloses methods for treating cancer and diagnosing cancer.Type: ApplicationFiled: September 9, 2013Publication date: February 6, 2014Applicant: The Boad of Trustees of the University of IllinoisInventors: Ananda Chakrabarty, Tapas Das Gupta, Tohru Yamada, Arsenio Fialho
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Patent number: 8642534Abstract: Therapeutic, diagnostic and environmental monitoring methods employing proteins encoded by the rbmBCDEF gene cluster and by bap1.Type: GrantFiled: January 16, 2007Date of Patent: February 4, 2014Assignee: The Regents of the University of CaliforniaInventor: Fitnat Yildiz
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Publication number: 20140033361Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: March 13, 2013Publication date: January 30, 2014Applicants: E.I Du PONT de NEMOURS and COMPANY, PIONEER HI BRED INTERNATIONAL INCInventors: Daniel J. Altier, Jennifer K. Barry, Carol A. Hendrick, Lu Liu, Phillip A. Patten, Claudia D. Perez-Ortega, Eric J. Schepers, Weiping Xie, Nasser Yalpani, Jianzhou Zhao, Xiaohong Zhong, Genhai Zhu
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Publication number: 20140033371Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: ApplicationFiled: October 3, 2013Publication date: January 30, 2014Applicants: PIONEER HI-BRED INTERNATIONAL INC, E I DU PONT DE NEMOURS AND COMPANYInventors: KEVIN E. MCBRIDE, MICHAEL W. LASSNER, LOREN L. LOOGER, BRIAN MCGONIGLE
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Publication number: 20140030286Abstract: The present invention relates to a peptide capable of forming a covalent complex consisting either of the Jo peptide, a derivative or a fragment thereof, or of the In peptide, a derivative or a fragment thereof. The present invention relates to the various uses thereof.Type: ApplicationFiled: March 26, 2012Publication date: January 30, 2014Inventors: Thierry Vernet, Anne-Marie Di Guilmi
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Publication number: 20140030287Abstract: The present invention relates to peptides of the enolase protein from Staphylococcus aureus as well as nucleic acid and nucleic acid sequence homologues encoding the peptides. The present invention also relates to a composition, particularly a S. aureus vaccine, comprising one or more of the enolase peptides described herein or a fragment, derivative or variant thereof capable of generating an immune response that induces a protective antibody response or opsonophagocytic activity of human neutrophils for S. aureus. The present invention also encompasses methods of treating and/or reducing the likelihood of a Staphylococcus infection by administering a composition of the invention.Type: ApplicationFiled: October 3, 2013Publication date: January 30, 2014Inventors: TESSIE B. MCNEELY, LESLIE COPE, SHARON SMITH, AMITA JOSHI, IRENE PAK, ARTHUR FRIDMAN
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Publication number: 20140030285Abstract: Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.Type: ApplicationFiled: July 17, 2013Publication date: January 30, 2014Applicants: Brookhaven Sciences Associates, LLC, Research Foundation of the State University of New York, University of RochesterInventors: Benjamin J. Luft, John J. Dunn, Shohei Koide, Catherine L. Lawson
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Patent number: 8636999Abstract: The invention provides compositions and methods for stable plasmid maintenance and protein expression in bacteria. Further provided are compositions and methods for promoting competence in bacteria that are otherwise not transformable.Type: GrantFiled: June 16, 2010Date of Patent: January 28, 2014Assignee: The Regents of the University of CaliforniaInventors: Joe Pogliano, Alan Derman
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Patent number: 8632783Abstract: Staphylococcus aureus Hla polypeptides having various deletions, insertions, and/or mutations which are useful for immunization are provided herein. Also provided herein are Hla heptamers which are non-haemolytic. Additionally, an effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens, including Hla polypeptides having deletions, insertions, and/or mutations, are identified for use in immunization. These polypeptides may optionally be used in combination with S. aureus saccharides.Type: GrantFiled: September 15, 2011Date of Patent: January 21, 2014Assignee: Novartis AGInventors: Fabio Bagnoli, Luigi Fiaschi
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Publication number: 20140017727Abstract: The invention provides protective antigens which are useful in vaccine compositions to induce protection against gram positive bacteria, particularly against S. agalactiae, S. pyogenes, S. pneumoniae, S. aureus, S. suis, and S. equi.Type: ApplicationFiled: June 7, 2013Publication date: January 16, 2014Inventors: Andrea Guido Oreste Manetti, Immaculada Margarit Y Ros, Guido Grandi
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Patent number: 8628917Abstract: The invention relates to the polynucleotide sequence of a nontypeable stain of Haemophilus influenzae (NTHi) and polypeptides encoded by the polynucleotides and uses thereof. The invention also relates to NTHi genes which are upregulated during or in response to NTHi infection of the middle ear and/or the nasopharynx.Type: GrantFiled: July 19, 2012Date of Patent: January 14, 2014Assignees: Nationwide Children's Hospital, Inc., The Board of Regents of the University of Oklahoma, Children's Hosptial Inc.Inventors: Lauren O. Bakaletz, Robert S. Munson, Jr., David W. Dyer
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Patent number: 8629243Abstract: Variant sucrose transporter polypeptides that enable faster sucrose utilization in bacteria are described. Additionally, variant or recombinant bacteria comprising these variant sucrose transporter polypeptides, and methods of utilizing the bacteria to produce products such as glycerol and glycerol-derived products are provided.Type: GrantFiled: August 16, 2011Date of Patent: January 14, 2014Assignee: E I du Pont de Nemours and CompanyInventors: Qi Chen, Qiong Cheng, Jian Ping Lai, Kristin Ruebling-Jass
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Patent number: 8629326Abstract: The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: GrantFiled: December 16, 2011Date of Patent: January 14, 2014Assignee: Novozymes, Inc.Inventors: Kristian Krogh, Paul Harris
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Patent number: 8629259Abstract: An isolated polynucleotide is provided. The isolated polynucleotide comprising a nucleic acid sequence encoding a polypeptide of a Type II reaction center of a photosynthetic organism, the nucleic acid sequence being capable of imparting the type II reaction center with an activity under a temperature range different than that of the type II reaction center endogenous to the photosynthetic organism. Also provided are methods of using the sequences for generating photosynthetic organisms or tailor-made thermotolerance.Type: GrantFiled: July 22, 2007Date of Patent: January 14, 2014Assignee: Yeda Research and Development Co. Ltd.Inventors: Avigdor Scherz, Oksana Shlyk-Kerner, Ilan Samish, David Kaftan, Jorge Dinamarca
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Patent number: 8629260Abstract: The present disclosure provides methods of selecting and uses of anti-arthropod vector vaccines to prevent Leishmaniasis. The present disclosure also provides compositions for vaccines to prevent Leishmaniasis.Type: GrantFiled: December 11, 2012Date of Patent: January 14, 2014Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Jesus G. Valenzuela, Yasmine Belkaid, Shaden Kamhawi, David Sacks, Jose M.C. Ribeiro
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Patent number: 8629323Abstract: The invention provides isolated and at least partially-purified dicamba-degrading enzymes, isolated DNA molecules coding for dicamba-degrading enzymes, DNA constructs coding for dicamba-degrading enzymes, transgenic host cells comprising DNA coding for dicamba-degrading enzymes, and transgenic plants and plant parts comprising one or more cells comprising DNA coding for dicamba-degrading enzymes. Expression of the dicamba-degrading enzymes results in the production of dicamba-degrading organisms, including dicamba-tolerant plants. Finally, the invention provides a method of selecting transformed plants and plant cells based on dicamba tolerance and a method of selecting or screening transformed host cells, intact organisms and parts of organisms based on the fluorescence of 3,6-dichlorosalicylic acid produced as a result of dicamba degradation.Type: GrantFiled: January 12, 2012Date of Patent: January 14, 2014Assignee: Board of Regents of the University of NebraskaInventors: Donald P. Weeks, Xiao-Zhuo Wang, Patricia L. Herman
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Publication number: 20140010835Abstract: The present invention relates to a polypeptide comprising a mutant fragment of an outer surface protein A (OspA), a nucleic acid coding the same, a pharmaceutical composition (particularly for use as a medicament of in a method of treating or preventing a Borrelia infection) comprising the polypeptide and/or the nucleic acid, a method of treating or preventing a Borrelia infection and a method of immunizing a subject.Type: ApplicationFiled: March 14, 2013Publication date: January 9, 2014Inventors: Pär Comstedt, Markus Hanner, Urban Lundberg, Andreas Meinke, Wolfgang Schueler, Benjamin Wizel
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Publication number: 20140011203Abstract: The genomic DNA of Streptoverticillium sp. 3-7, which produces UK-2, was analyzed to identify a region expected to be a UK-2 biosynthetic gene cluster. Moreover, by colony hybridization, DNAs in the region were successfully isolated. Further, the DNAs were used to prepare a strain in which the genes present in the region were disrupted. The strain was found not to produce UK-2. It was verified that the genomic region was the UK-2 biosynthetic gene cluster. Furthermore, Streptoverticillium sp. 3-7 was transformed by introduction of a vector in which the isolated UK-2 biosynthetic gene cluster was inserted. It was also found out that the UK-2 productivity by the transformant was improved about 10 to 60 times or more in comparison with that of the parental strain. Moreover, it was revealed that 2 copies of the UK-2 biosynthetic gene cluster were present per cell in these transformants, respectively.Type: ApplicationFiled: July 8, 2013Publication date: January 9, 2014Inventors: Koei KOBAYASHI, Naomi SUMIDA, Koji YANAI
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Patent number: 8624011Abstract: Compositions, recombinant vaccines and live attenuated pathogens comprising one or more isolated nucleic acid molecules that encode an immunogen in combination with an isolated nucleic acid molecule that encodes IL-15Ra or a functional fragment thereof are disclosed. Methods of inducing an immune response in an individual against an immunogen, using such compositions are disclosed.Type: GrantFiled: September 14, 2010Date of Patent: January 7, 2014Assignee: The Trustees of the University of PennsylvaniaInventors: David B Weiner, Kimberly A Kraynyak, Michele Kutzler
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Patent number: 8623609Abstract: The present invention is directed to proteins expressed by Mycobacterium tuberculosis and not by BCG and their use as diagnostic reagents.Type: GrantFiled: June 21, 2011Date of Patent: January 7, 2014Assignee: Rutgers, The State University of New JerseyInventor: Maria L. Gennaro
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Publication number: 20140007292Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest, as probes for the isolation of other homologous (or partially homologous) genes. The insecticidal proteins find use in controlling, inhibiting growth or killing lepidopteran, coleopteran, dipteran, fungal, hemipteran, and nematode pest populations and for producing compositions with insecticidal activity.Type: ApplicationFiled: March 11, 2013Publication date: January 2, 2014Applicant: Pioneer Hi Bred International IncInventors: David C. Cerf, James J. English, Carol A. Hendrick, Lu Liu, Jarred K. Oral, Phillip A. Patten, Barbara A. Rosen, Ute Schellenberger, Ingrid A. Udranszky, Jun-Zhi Wei, Genhai Zhu
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Publication number: 20130347141Abstract: A nucleic acid expression vector comprising a nucleic acid sequence encoding a dominant negative T3SS protein is disclosed. The nucleic acid expression vector further comprising a cis acting regulatory element capable of driving transcription of the nucleic acid sequence in a plant cell. Moreover, the dominant negative T3SS protein mediates assembly of a dysfunctional needle complex.Type: ApplicationFiled: March 1, 2012Publication date: December 26, 2013Applicant: FUTURAGENE ISRAEL LTD.Inventors: Hanan Stein, Dror Avisar
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Patent number: 8614079Abstract: The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.Type: GrantFiled: August 28, 2012Date of Patent: December 24, 2013Assignees: Novozymes, Inc, Novozymes A/SInventors: Soren Flensted Lassen, Paul Harris, Elena Vlasenko, Kristian Krogh
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Patent number: 8614075Abstract: The present invention relates to mutant ?5 desaturases, which have the ability to convert dihomo-?-linolenic acid [DGLA; 20:3 ?-6] to arachidonic acid [ARA; 20:4 ?-6] and/or eicosatetraenoic acid [ETA; 20:4 ?-3] to eicosapentaenoic acid [EPA; 20:5 ?-3] and which possess at least one mutation within the HPGG motif of the cytochome b5-like domain. Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding ?5 desaturases, along with a method of making long chain polyunsaturated fatty acids [“PUFAs”] using these mutant ?5 desaturases in oleaginous yeast, are disclosed.Type: GrantFiled: January 8, 2013Date of Patent: December 24, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Quinn Qun Zhu, Dana M. Walters Pollak
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Publication number: 20130330370Abstract: Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or prophylactic treatment of B. hyodysenteriae disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of diseases in animals caused by other Brachyspira species.Type: ApplicationFiled: June 10, 2013Publication date: December 12, 2013Inventors: David J. Hampson, Tom La, Matthew I. Bellgard, Nyree D. Phillips
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Publication number: 20130331550Abstract: The present inventors have solved the crystal structure of an Escherichia coli bacterial lipocalin polypeptide, which depicts a monomeric protein. Previous crystal structures have been reported, but these appear to be inaccurate, as they predicted, e.g., a dimeric protein. The crystal structure of a bacterial lipocalin provided by the present invention leads to numerous uses. For example, the present invention provides for the design, construction and use of recombinant libraries of diversified bacterial lipocalins resulting from a bacterial lipocalin polypeptide “backbone”.Type: ApplicationFiled: September 7, 2011Publication date: December 12, 2013Inventors: Arne Skerra, Andre Schiefner
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Publication number: 20130333074Abstract: The present invention relates to a polypeptide (BIG1) and variants thereof capable of enhancing the rate of cell-division of a microorganism or plant cell, as well as nucleic acid molecules encoding said polypeptides, vectors comprising said nucleic acid molecules and host cells transformed or transfected with said vectors and expressing said polypeptides. The BIG1 polypeptide which has been identified in the marine centric diatom Thalassiosira pseudonana, variants thereof and nucleic acids encoding these may be used in methods of enhancing the rate of cell-division of microorganisms, plant cells or plants which produce useful sub stances or exhibit useful properties, to increase the yield thereof.Type: ApplicationFiled: February 10, 2012Publication date: December 12, 2013Applicants: University of Washington through its Center for Commercialization, University of East AngliaInventors: Thomas Mock, Rachel Elizabeth Hipkin
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Publication number: 20130331559Abstract: To identify conserved and variable regions of the 16 S rRNA, an instant evolution experiment was performed on the entire 16 S rRNA. Analysis of these mutants identified regions that are required for function. These conserved sequences may be used as targets for pharmaceuticals that are taxonomically specific and which are refractory to the development of drug resistance.Type: ApplicationFiled: May 14, 2012Publication date: December 12, 2013Applicant: WAYNE STATE UNIVERSITYInventor: Philip R. Cunningham
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Patent number: 8604178Abstract: Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.Type: GrantFiled: September 18, 2007Date of Patent: December 10, 2013Assignees: The Board of Trustees of the University of Arkansas, The Texas A&M University of SystemInventors: Walter Bottje, Billy Hargis, Luc Berghman, Young Min Kwon, Kimberly Cole, Mandy Cox, Sherryll Layton
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Publication number: 20130323281Abstract: Bacterial flagellin protein is modified to improve adjuvant activity.Type: ApplicationFiled: May 23, 2013Publication date: December 5, 2013Inventors: Yuan Lu, James Robert Swartz
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Publication number: 20130323274Abstract: Variants of the pathogenic E. coli ‘AcfD precursor’ have been identified with increased solubility as compared to the native AcfD protein that raise a substantially similar immune response in a subject as the native AcfD protein.Type: ApplicationFiled: May 29, 2013Publication date: December 5, 2013Applicant: NOVARTIS AGInventors: Laura SERINO, Mariagrazia PIZZA, Danilo GOMES MORIEL, Maria Rita FONTANA
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Patent number: 8586022Abstract: Provided are diagnostic and pharmaceutical compositions containing a microorganism or a cell containing a DNA molecule encoding a detectable protein or a protein that a detectable signal, such as a luminescent or fluorescent protein. Methods of tumor targeting and tumor imaging using the microorganisms and cells are provided. Also provided are therapeutic methods in which the microorganisms and cells, which can encoded a therapeutic protein, such as a cytotoxic or cytostatic protein, are administered.Type: GrantFiled: October 31, 2007Date of Patent: November 19, 2013Assignee: Genelux CorporationInventors: Aladar A. Szalay, Yong A. Yu, Tatyana Timiryasova, Shahrokh Shabahang
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Patent number: 8586329Abstract: The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein the polypeptide comprises at least one degradation signal in the light chain of the neurotoxin polypeptide as well as vectors and host cells comprising the polynucleotide, polypeptides encoded thereby and antibodies specifically binding to the polypeptides. Moreover, the invention relates to medicaments comprising the polynucleotides and polypeptides, as well as specific therapeutic applications thereof. Furthermore, the present invention contemplates methods for the manufacture of the polypeptides and medicaments.Type: GrantFiled: July 1, 2010Date of Patent: November 19, 2013Assignee: Merz Pharma GmbH & Co. KGaAInventors: Fred Hofmann, Jurgen Frevert
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Publication number: 20130302380Abstract: This invention provides an IFN inducer comprising, as an active ingredient, lactic acid bacteria and capable of inducing IFN production, an immunopotentiating agent or prophylactic agent against virus infection comprising such inducer, and a food or drink product comprising such IFN inducer and having IFN-inducing activity, immunopotentiating activity, or prophylactic activity against virus infection. The agent for inducing IFN production comprises, as active ingredients, lactic acid bacteria that can activate plasmacytoid dendritic cells (pDCs) and promote IFN production, such as Lactococcus garvieae NBRC100934, Lactococcus lactis subsp. cremoris JCM16167, Lactococcus lactis subsp. cremoris NBRC100676, Lactococcus lactis subsp. hordniae JCM1180, Lactococcus lactis subsp. hordniae JCM11040, Lactococcus lactis subsp. lactis NBRC12007, Lactococcus lactis subsp. lactis NRIC1150, Lactococcus lactis subsp. lactis JCM5805, Lactococcus lactis subsp.Type: ApplicationFiled: December 28, 2011Publication date: November 14, 2013Inventors: Daisuke Fujiwara, Kenta Jonai, Tetsu Sugimura
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Publication number: 20130302908Abstract: The present invention relates to functional, modified glucose-galactose binding proteins (GGBPs), that have a greater melting temperature (Tm) than a reference GGBP. The present invention also relates to biological sensors, e.g., glucose sensors, comprising these thermostable GGBPs. The present invention also relates to nucleic acids encoding these thermostable GGBPs.Type: ApplicationFiled: July 24, 2013Publication date: November 14, 2013Inventors: Terry J. Amiss, Erin M. Gill, Douglas Byron Sherman
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Publication number: 20130302855Abstract: The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type-and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene-and DNA-sequences, as well as protein-sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield.Type: ApplicationFiled: August 1, 2011Publication date: November 14, 2013Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Klaus Selber, Bernhard Weingaertner, Hermann Wehlmann, Winfried Rosen, Alfred Puhler, Patrick Schwientek, Jörn Kalinowski, Udo Wehmeier
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Patent number: 8580556Abstract: Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.Type: GrantFiled: August 1, 2012Date of Patent: November 12, 2013Assignees: E. I. du Pont de Nemours and Company, Pioneer Hi-Bred International Inc.Inventors: Kevin E McBride, Michael W Lassner, Loren L Looger, Brian McGonigle
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Patent number: 8580940Abstract: Protoporphyrinogen oxidase having an activity of imparting acifluorfen resistance and gene thereof are provided. Cyanobacterium protoporphyrinogen oxidase gene is identified by introducing a protoporphyrinogen oxidase gene of Arabidopsis into cyanobacterium, disrupting a cyanobacterium gene with a transposon, selecting a mutant strain in which protoporphyrinogen oxidase gene is disrupted, identifying the disrupted protoporphyrinogen oxidase gene, and isolating the disrupted protoporphyrinogen oxidase gene. This procedure is effective as a gene isolation technique when a protein derived from other organism species that is homologous to a known protein (e.g., protoporphyrinogen oxidase from cyanobacterium) can not be found in a gene database of the other species.Type: GrantFiled: January 26, 2012Date of Patent: November 12, 2013Assignees: Nippon Soda Co., Ltd., National University Corporation Hokkaido UniversityInventors: Ayumi Tanaka, Ryouichi Tanaka, Kazushige Kato, Takako Fukagawa
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Patent number: 8580939Abstract: The invention provides a bacterium containing a polynucleotide comprising a nucleic acid encoding a heterologous antigen, as well as fusion protein partners. Also provided are vectors for mediating site-specific recombination and vectors comprising removable antibiotic resistance genes.Type: GrantFiled: May 2, 2011Date of Patent: November 12, 2013Assignee: Aduro BiotechInventors: Thomas W. Dubensky, Jr., Justin Skoble, Peter M. Lauer, David N. Cook
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Patent number: 8574886Abstract: The present invention relates to methods for producing a hyaluronic acid, comprising: (a) cultivating a Bacillus host cell under conditions suitable for production of the hyaluronic acid, wherein the Bacillus host cell comprises a nucleic acid construct comprising a hyaluronan synthase encoding sequence operably linked to a promoter sequence foreign to the hyaluronan synthase encoding sequence; and (b) recovering the hyaluronic acid from the cultivation medium. The present invention also relates to an isolated nucleic acid sequence encoding a hyaluronan synthase operon comprising a hyaluronan synthase gene and a UDP-glucose 6-dehydrogenase gene, and optionally one or more genes selected from the group consisting of a UDP-glucose pyrophosphorylase gene, UDP-N-acetylglucosamine pyrophosphorylase gene, and glucose-6-phosphate isomerase gene.Type: GrantFiled: February 21, 2012Date of Patent: November 5, 2013Assignee: Novozymes, Inc.Inventors: Regine Behr, William Widner, Maria Tang, Stephen Brown, Leslie Naggiar, Linda Sternberg
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Patent number: 8574884Abstract: The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.Type: GrantFiled: January 6, 2012Date of Patent: November 5, 2013Assignee: Danisco US Inc.Inventors: Andrew Shaw, Louise Wallace, David A. Estell, Ronaldus W. J. Hommes, Sang-Kyu Lee, Hiroshi Oh, Eugene S. Sadlowski
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Patent number: 8575323Abstract: Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are methods for transporting sugars across cell membranes using isolated and/or purified polypeptides and nucleic acid sequences from Alicyclobacillus acidocaldarius.Type: GrantFiled: December 20, 2012Date of Patent: November 5, 2013Assignee: Battelle Energy Alliance, LLCInventors: David N. Thompson, William A. Apel, Vicki S. Thompson, David W. Reed, Jeffrey A. Lacey
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Patent number: 8575425Abstract: Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for pesticidal polypeptides are provided. The coding sequences can be used in DNA constructs or expression cassettes for transformation and expression in plants and bacteria. Compositions also comprise transformed bacteria, plants, plant cells, tissues, and seeds. In particular, isolated pesticidal nucleic acid molecules are provided. Additionally, amino acid sequences corresponding to the polynucleotides are encompassed. In particular, the present invention provides for nucleic acid molecules comprising nucleotide sequences encoding the amino acid sequence shown in SEQ ID NO:2, 3, or 4, the nucleotide sequence set forth in SEQ ID NO:1, 9, 10, or 11, as well as variants and fragments thereof.Type: GrantFiled: July 1, 2010Date of Patent: November 5, 2013Assignee: Athenix CorporationInventors: Nalini Manoj Desai, Jill Hinson, Deepa Balasubramanian, Kimberly S. Sampson, Daniel J. Tomso, Duane Alan Lehtinen, Nicholas Duck, Rong Guo, Volker Heinrichs
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Publication number: 20130288300Abstract: Provided are isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.Type: ApplicationFiled: February 23, 2012Publication date: October 31, 2013Applicant: Novoozymes A/SInventors: Yu Zhang, Junxin Duan, Lan Tang, Wenping Wu
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Publication number: 20130291234Abstract: The present invention relates to a gene encoding Synechocystis putative DNA binding stress protein (SyDBSP protein) derived from cyanobacteria Synechocystis PCC6906; a method for enhancing the salt tolerance of a plant comprising transforming a plant cell with a recombinant vector comprising the SyDBSP gene and overexpressing the SyDBSP gene; a plant having enhanced salt tolerance produced by the aforementioned method, and seed of the plant.Type: ApplicationFiled: October 13, 2011Publication date: October 31, 2013Applicant: KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGYInventors: Jang Ryol Liu, Suk Weon Kim, Jong Hyun Kim, Sung Ran Min, Won Joong Jeong, Myung Suk Ahn, Young Min Park, Myung Jin Oh, Ji Hyun Park