Oxygen Double Bonded And Nitrogen Bonded Directly To The Same Carbon Patents (Class 536/53)
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Publication number: 20130225523Abstract: A glycodendrimer comprising: a) a non-toxic dendrimer polypropyletherimine core supporting 16 terminal carboxylic acid groups, and b) conjugated to said core 2, 3, 4 or 5 glucosamine molecules, wherein each glucosamine is linked directly through a zero length amide bond with a residue of a terminal carboxylic acid group. The invention also extends to defined populations comprising said glycodendrimer molecules, pharmaceutical compositions comprising said molecules or populations, process for preparing the molecules and formulations, and therapeutic uses of the molecules, populations and compositions.Type: ApplicationFiled: August 22, 2011Publication date: August 29, 2013Applicant: IMPERIAL INNOVATIONS LIMITEDInventors: Sunil Shaunak, Ian Alfred Teo
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Publication number: 20130224830Abstract: The present invention addresses the problem of providing an eggshell membrane solubilization method that is capable of solving the problems associated with carrying out treatment using acids and alkalis, or problems associated with the processing methods of the conventional art that use proteases; in other words, an eggshell membrane solubilization method that is capable of solving at least one of the following problems: (1) the need for pretreatment such as pulverization, sonication or boiling; (2) the need for prolonged treatment; and (3) a low decomposition rate (approximately 20%). Eggshell membranes are efficiently solubilized by using a protease in combination with a reducing agent.Type: ApplicationFiled: August 12, 2011Publication date: August 29, 2013Applicant: AMANO ENZYME INC.Inventor: Shun-ichi Tanaka
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Publication number: 20130203979Abstract: This invention provides compounds represented by the structure of the general formula (A): wherein L is a lipid or a phospholipid, Z is either nothing, ethanolamine, serine, inositol, choline, or glycerol, Y is either nothing or a spacer group ranging in length from 2 to 30 atoms, X is a physiologically acceptable monomer, dimer, oligomer, or polymer, wherein X is a glycosaminoglycan; and n is a number from 1 to 1000, wherein any bond between L, Z, Y and X is either an amide or an esteric bond.Type: ApplicationFiled: January 11, 2013Publication date: August 8, 2013Applicant: YISSUM RESEARCH DEVELOPMENT COMPANYInventor: YISSUM RESEARCH DEVELOPMENT COMPANY
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Publication number: 20130203980Abstract: For the first time, an O-specific polysaccharide antigen that is a Shigella Sonnei, phase I, exopolysaccharide has been produced and characterized, said exopolysaccharide being an authentic natural compound in the form of a bacterial capsular polysaccharide. The exopolysaccharide contains a non-toxic lipid component, namely non-hydroxylated fatty acids, and exhibits low pyrogenicity and high immunogenicity. Without using lipopolysaccharides as the source of production, an exopolysaccharide with a high degree of purity is produced from a liquid phase culture of S. sonnei bacteria by means of a workable industrial method with a high yield.Type: ApplicationFiled: May 6, 2011Publication date: August 8, 2013Inventors: Petr Gennadievich Aparin, Vyacheslav Leonidovich Lvov, Stanislava Ivanovan Elkina, Marina Eduardovna Golovina, Vladimir Igorevich Shmigol
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Publication number: 20130196897Abstract: To develop glucosamine (GlcN) pro-drugs with properties superior to the presently available GlcN products, we have synthesized derivatives with improved pharmaceutical properties. The synthesized derivatives include peptide-GlcN ester and amide conjugates where the peptide portion consists of one or more amino acids. One such compound is (5-amino-3,4,6-trihydroxyoxan-2-yl)methyl 2-(2-aminoacetamido)-3-methylbutanoate or glycine-valine-COO-GlcN (GV-GlcN).Type: ApplicationFiled: September 19, 2012Publication date: August 1, 2013Inventors: Fahkreddin Jamali, Kamalijit Kaur, Mohammadhossien Gilzad
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Publication number: 20130195873Abstract: Immunogenic compositions that contain haptens consisting of carbohydrate moieties are useful to induce an immune response to provide antibodies to epitopes contained in CA215 and also to elicit an immune response to cancers expressing these epitopes.Type: ApplicationFiled: July 14, 2011Publication date: August 1, 2013Applicant: Vancouver Biotech LTD.Inventor: Chi-Yu Gregory Lee
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Publication number: 20130195803Abstract: Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.Type: ApplicationFiled: July 12, 2011Publication date: August 1, 2013Applicant: The Regents of the University of CaliforniaInventors: J. Bruce German, David Mills, Carlito B. Lebrilla, Daniela Barile, Riccardo LoCascio
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Patent number: 8497365Abstract: The present invention relates to novel compositions comprising polymeric moieties covalently attached to therapeutic agents, wherein the therapeutic agent is attached to the polymeric moiety through a tether. By selecting from a variety of tether groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein.Type: GrantFiled: August 4, 2011Date of Patent: July 30, 2013Inventors: Mark E. Davis, Jungyeon Hwang, Tianyi Ke, Ching-Jou Lim, Thomas Schluep
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Publication number: 20130190258Abstract: Methods and small molecule compounds for inhibition of cancer cell proliferation are provided. One example of a class of compounds that may be used is represented by the compound of Formula I or a pharmaceutically acceptable salt, N-oxide or solvate thereof, wherein A, B, D, E, F, G, I, J, R, R1, R2, R2?, R3, R4, R5, R6, R7, R8, R9 are as described herein.Type: ApplicationFiled: January 24, 2013Publication date: July 25, 2013Inventors: John CASHMAN, Mark MERCOLA, Dennis SCHADE, Masanao TSUDA
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Publication number: 20130190268Abstract: The invention relates to novel polysaccharides with an antithrombotic activity, having at least one covalent bond with biotin or a biotin derivative, wherein said covalent bond is resistant to metabolic cleavage and comprises a linkage X selected from the group consisting of —O—, —N(R)—, —N(R)—CO— and —N(R?)—CO—N(R?)—, wherein R is an alkyl group and R? and R?, which may be identical or different, are, independently of one another, a hydrogen atom or alkyl group.Type: ApplicationFiled: March 8, 2013Publication date: July 25, 2013Applicant: SANOFIInventor: SANOFI
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Publication number: 20130178613Abstract: The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce ?Gal epitopes or ?Gal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-?Gal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.Type: ApplicationFiled: December 17, 2012Publication date: July 11, 2013Applicant: NewLink Genetics Corp.Inventor: NewLink Genetics Corp.
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Publication number: 20130178426Abstract: The invention has as its object the provision of a medicine capable of reducing a volume of emphysema-suffering pulmonary alveoli or alveolar sacs by means of a respiratory region volume inhibitor containing a coating film formation as a main component and capable of forming a coating film in a respiratory region, characterized by being used in such a way that the coating film-forming component is administered to an emphysema-suffering pulmonary alveolar parenchyma in a human-respiratory region in an amount of 0.004 to 200 g/application, preferably 0.07 to 20 g/application and more preferably 0.5 to 5 g/application on each occasion.Type: ApplicationFiled: August 10, 2011Publication date: July 11, 2013Applicant: Terumo Kabushiki KaishaInventors: Takao Anzai, Atsuhiko Nogawa, Yuichi Tada
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Publication number: 20130171696Abstract: The invention relates to a method for the synthesis of compounds of general formula (1A) and salts thereof wherein one of the R groups is an ?-sialyl moiety and the other is H, X1 represents a carbohydrate linker, A is a D-glucopyranosyl unit optionally substituted with fucosyl, R1 is a protecting group that is removable by hydrogenolysis, the integer m is 0 or 1, by a transsialidation reaction.Type: ApplicationFiled: July 15, 2011Publication date: July 4, 2013Applicant: Glycom A/SInventors: Andreas Schroven, Elise Champion, Gyula Dekany, Christoph Röhrig, Ioannis Vrasidas, Ignacio Figueroa Pérez, Markus Hederos, Julien Boutet, Ágnes Ágoston, Piroska Kovács-Pénzes, Ferenc Horváth, Christian Risinger, Gergely Pipa, Sándor Demkó, Lars Kröger
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Publication number: 20130171180Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportion, in particular a mixture of enantiomers, and particularly a racemate mixture, as well as to their process of preparation, their use in the peptide synthesis, said peptide and the use of said peptide.Type: ApplicationFiled: December 22, 2011Publication date: July 4, 2013Applicant: TFCHEMInventors: Geraldine Deliencourt-Godefroy, Hyacinthe Fillon, Thibaut Martin
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Publication number: 20130172289Abstract: The present invention concerns a method for obtaining sodium chondroitin sulphate from cartilage, notably of avian origin, as well as a sodium chondroitin sulphate preparation.Type: ApplicationFiled: December 28, 2011Publication date: July 4, 2013Applicant: PIERRE FABRE MEDICAMENTInventors: Nadine Chomarat, Paul Grech, Guillermo Cueto, Edouardo Rodriguez, Jean-François Boe
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Publication number: 20130165645Abstract: A compound, which inhibits SGLT1 (sodium-dependent glucose transporter 1) activity to suppress absorption of glucose or the like, thereby suppressing abnormal glucose tolerance or postprandial hyperglycemia in diabetes, is provided.Type: ApplicationFiled: August 19, 2011Publication date: June 27, 2013Applicant: TAISHO PHARMACEUTICAL CO., LTDInventors: Hiroyuki Kakinuma, Yohei Kobashi, Tomomichi Chonan, Fumiyasu Shiozawa, Yuki Iwata, Takahiro Oi, Kenichi Kawabe
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Publication number: 20130164709Abstract: Substituted saccharide compounds, dental compositions comprising substituted saccharide compounds, and methods of using dental compositions are described. In one embodiment, the substituted saccharide amide compound comprises a hydrophobic group and at least one free-radically polymerizable group with the proviso that the hydrophobic group is not bonded to the ethylenically unsaturated carbon atom of the free-radically polymerizable group. The hydrophobic group is typically bonded to a nitrogen atom of a saccharide amine residue or a carbonyl moiety of saccharide amide residue.Type: ApplicationFiled: August 19, 2011Publication date: June 27, 2013Applicant: 3M INNOVATIVE PROPERTIES COMPANYInventors: Jie Yang, Sumita B. Mitra, Yi He, Brian A. Shukla, Naimul Karim, Afshin Falsafi, Richard B. Ross, Paul R. Klaiber, George W. Griesgraber
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Patent number: 8466113Abstract: The present invention provides 4-isopropylphenyl glucitol compounds which have no tendency to accumulate in the body and which inhibit SGLT1 activity to suppress postprandial hyperglycemia (or impaired glucose tolerance) through suppression of glucose absorption in the small intestine, whereby the compounds, for example, can suppress the onset of diabetes and metabolic syndrome or can treat these diseases. A 4-isopropylphenyl glucitol compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein R1 represents a hydrogen atom, etc., R2 represents a methyl group, etc., R3 represents a C1-4 alkyl group substituted with an amino group(s), etc., and R4 represents a hydrogen atom, etc.Type: GrantFiled: February 23, 2010Date of Patent: June 18, 2013Assignee: Taisho Pharmaceutical Co., Ltd.Inventors: Hiroyuki Kakinuma, Yohei Kobashi, Tomomichi Chonan, Takahiro Oi, Fumiyasu Shiozawa, Yuki Iwata, Kenichi Kawabe
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Publication number: 20130144050Abstract: A highly stable crystal of (1S)-1,5-anhydro-1-[5-(4-{(1E)-4-[(1-{[2-(dimethylamino)ethyl]amino}-2-methyl-1-oxopropan-2-yl)amino]-3,3-dimethyl-4-oxobut-1-en-1-yl}benzyl)-2-methoxy-4-(propan-2-yl)phenyl]-D-glucitol, and a process for producing the crystal are provided. Specifically, an ethanolate having the following physical properties, and a plurality of other crystal forms transformed from the ethanolate are provided: (a) Having peaks at 2?=5.9 degrees, 17.1 degrees, 17.6 degrees and 21.5 degrees in X-ray powder diffraction (Cu—K?); (b) Showing characteristic absorption bands at 3538 cm?1, 3357 cm?1, 2964 cm?1, 1673 cm?1, 1634 cm?1 and 1505 cm?1 in an infrared absorption spectrum; and (c) Having a melting point in a vicinity of 111° C.Type: ApplicationFiled: August 19, 2011Publication date: June 6, 2013Applicant: TAISHO PHARMACEUTICAL CO., LTD.Inventors: Yoshihiro Kimura, Koreaki Imura, Naoto Osaki, Ayumi Matsushima
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Patent number: 8450441Abstract: A polymer containing an N-linked sialo-glycan wherein a sialo-glycan is condensed to a ?-polyglutamic acid using a chemical compound having an amino group on one end and a carboxyl group on another end and represented by the structural formula (I). Formula (I) (In the formula, Z means a hydroxy group or a residue represented by the formula (II), and n represents an integer of 10 or more, with the proviso that any one or more of the Z's is represented by the formula in (II).) Formula (II) (In the formula, X means a hydroxy group or an acetylamino group, Y1 and Y2 mean a hydroxyl group or an N-acetylneuraminic acid residue, L means a hydrocarbon, an m represents 0 or an integer of 1 or 2, with the proviso that Y1 and Y2 are not the same.Type: GrantFiled: June 24, 2008Date of Patent: May 28, 2013Assignees: National University Corporation Shizuoka University, Shizuoka Prefectural Universities Corporation, Yamasa CorporationInventors: Taiichi Usui, Takeomi Murata, Takashi Suzuki, Ilpal Jwa, Yusuke Ohba, Tomoki Hamamoto, Toshitada Noguchi
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Publication number: 20130131321Abstract: The present invention relates to the use for affinity purification of an antibody or an fragment of an antibody, of a ligand-substituted matrix comprising a support material and at least one ligand covalently bonded to the support material, the ligand being represented by formula (I) wherein Sp is a spacer group; v is 0 or 1; Am is an amide group —NR1—C(O)—, and wherein either NR1 is attached to Ar1 and —C(O)— is attached to Ar2, or —C(O)— is attached to Ar1 and NR1 is attached to Ar2; and R1 is hydrogen or C1 to C4 alkyl, preferably hydrogen or methyl; and more preferably hydrogen; Ar1 is a divalent 5- or 6-membered substituted or unsubstituted aromatic ring; Ar2 is 5- or 6-membered heterocyclic aromatic ring which is (a) attached to a further 5- or 6-membered aromatic ring via a single bond; or (b) fused to a further 5- or 6-membered aromatic ring as part of a multicyclic ring system; or (c) attached to at least one substituent selected from C1 to C4 alkyl; C2 to C4 alkenyl; C2 to C4 alkynyl; aType: ApplicationFiled: August 3, 2011Publication date: May 23, 2013Applicant: GRAFFINITY PHARMACEUTICALS GMBHInventors: Holger Bittermann, Klaus Burkert, Marc Arnold, Oliver Keil, Thomas Neumann, Inge Ott, Kristina Schmidt, Daniel Schwizer, Renate Sekul
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Publication number: 20130131009Abstract: This invention provides cell culture compositions which produce significant quantities of high molecular weight hyaluronic acid. The cell cultures are obtained from cells of mole rats, such as naked mole rats and blind mole rats. The high molecular weight hyaluronic acid can be collected in the conditioned media of these cell cultures. These cell cultures provide a convenient source of large quantities of high molecular weight hyaluronic acid.Type: ApplicationFiled: March 24, 2011Publication date: May 23, 2013Applicant: UNIVERSITY OF ROCHESTERInventors: Vera Gorbunova, Andrei Seluanov, Christopher Hine
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Publication number: 20130123487Abstract: The invention relates to solid supports useful in medical applications that provide controlled release of drugs, such as peptides, nucleic acids and small molecules. The drugs are covalently coupled to the solid support through a linkage that releases the drug or a prodrug through controlled beta elimination.Type: ApplicationFiled: May 5, 2011Publication date: May 16, 2013Applicant: PROLYNX LLCInventors: Gary Ashley, Daniel V. Santi
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Publication number: 20130122094Abstract: The present invention provides sialic acid analogs and their compositions useful for the treatment of sialic acid deficiencies.Type: ApplicationFiled: October 24, 2012Publication date: May 16, 2013Applicant: ULTRAGENYX PHARMACEUTICAL, INC.Inventor: ULTRAGENYX PHARMACEUTICAL, INC.
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Publication number: 20130109808Abstract: Polymers comprising glucosamine (GlcN) are used to make medical devices. Examples include polyGlcN and carrier molecules containing multiple GlcN residues.Type: ApplicationFiled: September 7, 2012Publication date: May 2, 2013Applicant: THE JOHNS HOPKINS UNIVERSITYInventor: Jennifer H. Elisseeff
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Publication number: 20130098550Abstract: A method for adhering a medical device to biological tissue includes adhering an adhesive composition having a plurality of reactive members of a specific binding pair to tissue which has a plurality of complementary reactive members of the specific binding pair via click chemistry.Type: ApplicationFiled: March 24, 2011Publication date: April 25, 2013Applicant: COVIDIEN LPInventors: Tim Sargeant, Robert Ahmad Hadba, Joshua Stopek
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Publication number: 20130096081Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.Type: ApplicationFiled: December 5, 2012Publication date: April 18, 2013Applicant: ALLERGAN, INC.Inventors: Gabriel N. Njikang, Xiaojie Yu, Futian Liu, Nicholas J. Manesis
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Publication number: 20130096294Abstract: An amine or hydrazide derivative of a sialic acid unit, e.g. in a polysaccharide, is reacted with a bifunctional reagent at least one of the functionalities of which is an ester of N-hydroxy succinimide, to form an amide or hydrazide product. The product has a useful functionality, which allows it to be conjugated, for instance to proteins, drugs, drug delivery systems or the like. The process is of particular utility for derivatising amine groups introduced in sialic acid terminal groups of polysialic acids.Type: ApplicationFiled: October 8, 2012Publication date: April 18, 2013Applicant: Lipoxen Technologies LimitedInventor: Lipoxen Technologies Limited
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Patent number: 8410076Abstract: A cationized hyaluronic acid and/or a salt thereof includes a quaternary ammonium group-containing group, and has a degree of cationization of 0.15 to 0.6.Type: GrantFiled: April 23, 2008Date of Patent: April 2, 2013Assignee: Q.P. CorporationInventors: Kazunori Asaoka, Shunichi Fujikawa, Tomoyuki Kanemitsu, Wakako Sakamoto
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Publication number: 20130079291Abstract: N-acyl modified sialic acid (?-(2?6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (?-(2?6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.Type: ApplicationFiled: April 8, 2011Publication date: March 28, 2013Applicant: PEKING UNIVERSITYInventors: Xinshan Ye, Fan Yang, Xiujing Zheng
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Publication number: 20130078218Abstract: The invention provides methods for treating hepatitis C viral infections and related viral infections, as well as compounds and compositions that are useful for treating such infections.Type: ApplicationFiled: March 26, 2012Publication date: March 28, 2013Inventors: Yarlagadda S. Babu, Pooran Chand, Minwan Wu, Pravin L. Kotian, V. Satish Kumar, Tsu-Hsing Lin, Yahya El-Kattan, Ajit K. Ghosh
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Publication number: 20130079507Abstract: The present invention provides a separating agent for optical isomers that contains a cellulose derivative or amylose derivative that has an excellent enantioselective recognition ability. The present invention comprises a separating agent for optical isomers that uses a polysaccharide derivative provided by replacing all or a portion of the hydrogen atoms on the hydroxyl groups present in a polysaccharide with two specific atomic groups that act on optical isomers targeted for separation in an optical resolution, wherein the sum of the average introduction ratios of specific terminal substituents in these atomic groups is greater than 3.0 per monosaccharide unit.Type: ApplicationFiled: June 17, 2011Publication date: March 28, 2013Inventor: Yuki Kawata
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Publication number: 20130072638Abstract: The present invention relates to dimeric pentadentate chelators with exceptionally strong binding of metal ions, for detection, immobilization and purification of biomolecules. Dimeric chelators offer a cooperativity of binding of two adjacent immobilized metal ions simultaneously to a histidine-tagged biomolecule, which gives advantageous properties regarding strength of binding compared to a corresponding monomer chelator. In addition, a dimer increases the selectivity (ease of separation) against non-tagged biomolecules with low metal-ion affinity.Type: ApplicationFiled: May 30, 2011Publication date: March 21, 2013Applicant: GE HEALTHCARE BIO-SCIENCES ABInventors: Mattias Algotsson, Lars C. Andersson, Eggert Brekkan, Lee Hedemyr, Jean-Luc Maloisel, Ronnie Palmgren
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Publication number: 20130072388Abstract: Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3?-OH group is derivatized at the nucleobase to include a fluorescent dye attached via a linker to a photocleavable terminating group. The photocleavable-fluorescent group is designed to terminate DNA synthesis as well as be cleaved so that DNA oligomers can be sequenced efficiently in a parallel format. The design of such rapidly cleavable fluorescent groups on nucleotides and nucleosides can enhance the speed and accuracy of sequencing of large oligomers of DNA in parallel, to allow rapid whole genome sequencing, and the identification of polymorphisms and other valuable genetic information, as well as allowing further manipulation and analysis of nucleic acid molecules in their native state following cleavage of the fluorescent group.Type: ApplicationFiled: August 23, 2012Publication date: March 21, 2013Inventors: Weidong WU, Vladislav A. Litosh, Brian P. Stupi, Michael L. Metzker
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Publication number: 20130072438Abstract: Disclosed herein are opioid peptide conjugates (for example, opioid peptide esters). In some embodiments, the disclosed conjugates include an opioid peptide consisting of two to six amino acids and a moiety conjugated to the opioid peptide by an ester bond. In some examples, the moiety is an alcohol, a sugar, a lipid, or dehydroascorbic acid. Also disclosed are methods of altering nociception including administering an effective amount of one or more disclosed opioid peptide conjugates to a subject (such as a human subject).Type: ApplicationFiled: September 13, 2012Publication date: March 21, 2013Inventor: Joel S. Goldberg
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Publication number: 20130066064Abstract: A single-phase LPS extraction composition comprising water, an alcohol and a further organic solvent, where the amount of water is between about 0.8 to 1.2% (v/v).Type: ApplicationFiled: May 18, 2010Publication date: March 14, 2013Inventors: Philippe Charles, Geoffroy Geldhof, Vincent Mancuso
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Publication number: 20130059769Abstract: The present invention relates to topical glycosaminoglycan compositions, particularly hyaluronan compositions, that facilitate the penetration of modified glycosaminoglycans through the skin barrier into the epidermal and dermal layers of the skin, thereby allowing for the dermal administration of a glycosaminoglycan, such as hyaluronan, without requiring an injection. Through their ability to deliver hyaluronan to the epidermal and dermal layers, the present formulations are therefore suitable for use in dermal rejuvenation, enhancement, hyaluronan replenishment and protection therapy. The glycosaminoglycan compositions are also useful as delivery devices to facilitate the dermal and transdermal delivery of cosmetically and pharmaceutically active substances, including pharmaceuticals, polypeptides, proteins and similarly sized biomacromolecules, through the skin barrier.Type: ApplicationFiled: May 4, 2011Publication date: March 7, 2013Inventor: Eva Turley
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Patent number: 8389713Abstract: A photocrosslinked polysaccharide pseudo-sponge exhibiting a low swelling property and a high degradation ability in vivo while retaining a suitable strength. The polysaccharide pseudo-sponge is produced by a crosslinking reaction of a photoreactive polysaccharide obtained by introducing a photoreactive group into a polysaccharide, and exhibits a low swelling property and a blue dextran-low dyeaffinity.Type: GrantFiled: October 26, 2011Date of Patent: March 5, 2013Assignee: Seikagaku CorporationInventor: Tomoya Sato
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Patent number: 8367623Abstract: The invention is a glycolipid useful in treating autoimmune diseases and a medicine thereof as active ingredient for autoimmune diseases, represented by the formula wherein R1 is an aldopyranose group, R2 is a hydrogen atom or a hydroxyl group, R3 is —CH2—, —CH(OH)—CH2— or —CH?CH—, R4 is a hydrogen atom or CH3, x is 0-35, y and z represent integers satisfying y+z=0-3.Type: GrantFiled: August 14, 2002Date of Patent: February 5, 2013Assignee: Japan as Represented by President of National Center of Neurology and PsychiatryInventors: Takashi Yamamura, Sachiko Miyake
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Patent number: 8367830Abstract: The present invention relates to immobilization compounds of formula (I), immobilization products and preparations thereof as well as methods and uses for the identification of phosphatidylinositol kinase interacting compounds or for the purification or identification of phosphatidylinositol kinase proteins.Type: GrantFiled: May 14, 2010Date of Patent: February 5, 2013Assignee: Cellzome AGInventors: Kathryn Bell, Nigel Ramsden, Giovanna Bergamini Moore, Gitte Neubauer
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Publication number: 20130023658Abstract: The present invention generally relates to novel biocompatible crosslinked polysaccharide gel compositions, methods of their manufacture and use, and the novel crosslinkers used to make them. In one aspect of the invention, a novel polyethylene glycol crosslinking agent is described for crosslinking hyaluronic acid. In another aspect of the invention, novel crosslinking agents comprising more than two functional groups are described. These multifunctional crosslinking agents can be used on their own to crosslink hyaluronic acid, or they may be combined with bifunctional crosslinking agents in varying ratios to make hyaluronic acid of tunable mechanical strength and hardness. The present invention also discloses novel hyaluronic acid compositions that have been coated with polyethylene glycol and methods of their use.Type: ApplicationFiled: September 21, 2012Publication date: January 24, 2013Applicant: ALLERGAN, INC.Inventor: ALLERGAN, INC.
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Publication number: 20130023509Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.Type: ApplicationFiled: September 28, 2012Publication date: January 24, 2013Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.Inventor: ADAVANCED CARDIOVASCULAR SYSTEMS,IN
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Patent number: 8357794Abstract: An isolated polysaccharide has the structure [-?(1,3)-D-GalpNAc-?(1,4)-D-Glcp-]n The polysaccharide may be from a Bifidobacterium strain NCIMB41003. The polysaccharide exhibits immunomodulatory activity.Type: GrantFiled: May 2, 2008Date of Patent: January 22, 2013Assignee: The Procter & Gamble Company and Alimentary Health LimitedInventors: Raymond Alan Grant, Liam O'Mahony, Barbara Sheil
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Publication number: 20130017164Abstract: The invention relates to a cosmetic or dermatological composition comprising a hyaluronic acid derivative which comprises ureidopyrimidone units, to the said derivatives and to a cosmetic treatment method using them.Type: ApplicationFiled: December 14, 2010Publication date: January 17, 2013Applicant: L'OREALInventors: Sandrine Chodorowski-Kimmes, Maria Dalko
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Publication number: 20130017993Abstract: This invention relates to compounds represented by formula (I): wherein the variables are defined as herein above, which are useful for treating diseases and conditions mediated by the sodium D-glucose co-transporter (SGLT), e.g. diabetes. The invention also provides methods of treating such diseases and conditions, and compositions etc. for their treatment.Type: ApplicationFiled: September 13, 2012Publication date: January 17, 2013Applicant: NOVARTIS AGInventors: Gregory Raymond BEBERNITZ, Mark G. BOCK, Dumbala Srinivas REDDY, Atul Kashinath HAJARE, Vinod VYAVAHARE, Sandeep Bhausaheb BHOSALE, Suresh Eknath KURHADE, Videsh SALUNKHE, Nadim S. SHAIKH, Debnath BHUNIYA, P. Venkata PALLE, Lili FENG, Jessica LIANG
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Publication number: 20120329129Abstract: A magnetic nanoparticle is provided in the disclosure. The magnetic nanoparticle includes a magnetic nanoparticle; a biocompatible polymer of the following formula (II) covalently coupled to the magnetic nanoparticle, wherein R1 is alkyl, aryl, carboxyl, or amino; n is an integer from 5 to 1000; and m is an integer from 1 to 10.Type: ApplicationFiled: August 30, 2012Publication date: December 27, 2012Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Wen-Hsiang Chang, Wen-Uan Hsieh, Shiu-Hua Huang, Chin-I Lin, Shian-Jy Jassy Wang, Kelly Teng
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Publication number: 20120329755Abstract: Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.Type: ApplicationFiled: August 3, 2012Publication date: December 27, 2012Applicant: GlycoMimetics, Inc.Inventors: John L. Magnani, John T. Patton, JR., Arun K. Sarkar
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Publication number: 20120322974Abstract: 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.Type: ApplicationFiled: March 13, 2012Publication date: December 20, 2012Applicant: University of Georgia Research Foundation, Inc.Inventors: GEERT-JAN BOONS, Jun Guo, Xinghai Ning, Margaretha Wolfert
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Publication number: 20120316329Abstract: A modified hyaluronic acid and/or a salt thereof comprises a glycerin skeleton-containing group shown by the following general formula (1), —O—CH2—CHOH—CH2—OR1??(1) wherein, R1 represents a linear or branched alkyl group, or a linear or branched alkenyl group.Type: ApplicationFiled: February 18, 2011Publication date: December 13, 2012Applicant: KEWPIE CORPORATIONInventors: Shunichi Fujikawa, Masanori Kurokawa
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Publication number: 20120309708Abstract: The present invention relates to a method of treating a liquid composition containing lacto-N-biose, the method including: preparing a liquid composition containing lacto-N-biose having a pH at 25° C. of not less than 2.0 and not more than 5.5, and heating the liquid composition at a temperature of 65° C. or higher. The present invention can provide a treatment method that enables thermal decomposition of lacto-N-biose to be suppressed when a liquid composition containing lacto-N-biose is heated at a temperature of 65° C. or higher, a liquid preparation containing lacto-N-biose that is treated using the treatment method, a dried product produced from such a liquid preparation containing lacto-N-biose, and a method of producing a product containing lacto-N-biose.Type: ApplicationFiled: January 31, 2011Publication date: December 6, 2012Applicant: Morinaga Milk Industry Co., Ltd.Inventors: Motomitsu Kitaoka, Mamoru Nishimoto, Kanetada Shimizu