Halogen Bonded Directly To The Cyclopentanohydrophenanthrene Ring System Patents (Class 540/69)
Oxygen bonded directly at the 11-position of the cyclopentanohydrophenanthrene ring system (Class 540/70)
  • Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
    Patent number: 5837698
    Abstract: The present invention relates to a pharmaceutical composition or preparation which comprises hydroxyl containing steroidal hormones and organic nitrite/nitrate or other nitric oxide donating agents.
    Type: Grant
    Filed: May 2, 1996
    Date of Patent: November 17, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Foe S. Tjoeng, Mark G. Currie, Mark E. Zupec
  • Process for preparation of 9.alpha. -chloro-11.beta. formyloxypregna-3.20-diones
    Patent number: 5670676
    Abstract: Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethylformamide; at a temperature within the range of about -78.degree. to about 0.degree. C.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 23, 1997
    Assignee: Schering Corporation
    Inventors: Richard W. Draper, Eugene J. Vater
  • Process for preparation of 9.alpha.-chloro-11.beta.-formyloxypregna-3,20-diones
    Patent number: 5602248
    Abstract: Disclosed is a process for producing a compound of the formula: ##STR1## by reacting a compound of the formula: ##STR2## with: (1) a chlorinating reagent selected from an N-chloroimide or an N-chloroamide; (2) an anhydrous strong acid selected from orthophosphoric acid, alkylsulfonic acids, fluoroalkylsulfonic acids or arylsulfonic acids; and (3) anhydrous dimethyl formamide; at a temperature within the range of about -78.degree. to about 0.degree. C., under anhydrous conditions under an inert atmosphere.
    Type: Grant
    Filed: March 16, 1995
    Date of Patent: February 11, 1997
    Assignee: Schering Corporation
    Inventors: Richard W. Draper, Eugene J. Vater
  • Novel steroid derivatives, pharmaceutical compositions containing them and process for preparing same
    Patent number: 5053404
    Abstract: The invention relates to antiinflammatory compounds of the formula (I), ##STR1## wherein A stands for hydrogen or hydroxyl group;X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen;R stands for hydrogen, benzoyl or C.sub.1-8 alkanoyl group;R.sup.1 and R.sup.2, which are the same or different, stand for hydrogen or a C.sub.1-4 alkyl group; or one of R.sup.1 and R.sup.2 is hydrogen and the other is phenyl group; or R.sup.1 and R.sup.2 together form a C.sub.4-5 alkylene group;means a single or double bond between two adjacent carbon atoms,as well as pharmaceutical compositions containing these compounds and a process for their preparation.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: October 1, 1991
    Assignee: Richter Gedeon Vegyeszeti Gyar R. T.
    Inventors: Csaba Molnar, Gyorgy Hajos, Laszlo Szporny, Jozsef Toth, Arpad Kiraly, Anna Boor nee Mezei, Janos Csorgei, Kristina Szekely, Lilla Forgacs, Gyorgy Fekete, Bulcsu Herenyi, Sandor Holly, Jozsef Szunyog
  • Process for the preparation of 16,17 acetals of pregnane derivatives
    Patent number: 4695625
    Abstract: A process for the preparation of 16,17 acetals of pregnane derivatives by trans-ketalization of 16,17-acetonides is described.In the instance of the preparation of 16.alpha.,17.alpha.-butylidenedioxy-11.beta.,21-dihydroxypregna-1,4-diene- 3,20-dione, a compound having useful therapeutic properties, known also as budesonide, it is possible to obtain the more active epimer with high selectivity and remarkable economic advantages in comparison with the known methods.New 16,17 acetals of pregnane derivatives, which can be prepared by the method of the invention, are also described.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: September 22, 1987
    Assignee: Sicor Societa Italiana Corticosteroidi S.p.A.
    Inventor: Peter Macdonald
  • Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid
    Patent number: 4613463
    Abstract: This invention discloses an improved process for the production of corticoids from 17.alpha.-hydroxy steroids utilizing peroxymonosulfate.
    Type: Grant
    Filed: November 1, 1984
    Date of Patent: September 23, 1986
    Assignee: The Upjohn Company
    Inventor: Clifford E. Sacks