Addition Salts Of Morpholine Which Is Unsubstituted Or Hydrocarbyl Substituted Only Patents (Class 544/107)
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Patent number: 4529602Abstract: A method for the therapeutic treatment and/or prophylaxis of gastro-intestinal diseases using a sulfodehydroabietic acid of the formula: ##STR1## or a pharmaceutically acceptable salt thereof is disclosed.Type: GrantFiled: June 14, 1984Date of Patent: July 16, 1985Assignee: Tanabe Seiyaku Co., Ltd.Inventors: Hiroshi Wada, Masatoshi Kawamori, Hajime Tamaki, Yuichi Onoda
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Patent number: 4486429Abstract: Compounds of the formula I: ##STR1## in which R represents a hydrogen atom or an alkyl radical containing from 1 to 8 carbon atoms and R.sub.1 and R.sub.2, which may be identical or different independently represent a hydrogen atom, an alkyl radical containing from 1 to 4 carbon atoms, a --CONH.sub.2 radical, a --CO.sub.2 alk.sub.1 radical in which alk.sub.1 represents an alkyl radical containing from 2 to 8 carbon atoms, or an--SO.sub.2 alk.sub.2 radical in which alk.sub.2 represents an alkyl radical containing from 1 to 8 carbon atoms, or R.sub.1 and R.sub.2 together with the nitrogen atom form a heterocycle provided that R.sub.1 and R.sub.2 are not both hydrogen, as well as the alkali metal, alkaline earth metal, ammonium or amine salts of compounds of formula I in which R represents a hydrogen atom. These compounds are useful in treating hyperchlorhydria, gastric or gastroduodenal ulcers, gastritis, hiatal hernias and gastric or gastroduodenal ailments accompanied by gastric hyperacidity.Type: GrantFiled: October 20, 1982Date of Patent: December 4, 1984Assignee: Roussel UclafInventors: Mario Bianchi, Fernando Barzaghi
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Patent number: 4438112Abstract: Prostanoids are described of the formulae ##STR1## (and the salts thereof) in which: X is cis or trans --CH.dbd.CH-- or CH.sub.2 CH.sub.2 --;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.10 where R.sup.10 is H, C.sub.1-6 alkyl or aralkyl;Y is a saturated heterocyclic amino group; andR.sup.4 is aralkyl (in which the aryl portion is substituted by alkylthio, alkylsulphinyl, alkylsulphonyl, alkanoylamino, aroylamino, phenalkyl, aminosulphonyl, alkanoylaminosulphonyl, phenylsulphonyl, nitro, tetrazolyl, substituted phenyl or thienyl).These compounds inhibit blood platelet aggregation and have bronchodilatory action, and may be formulated for use as anti-asthmatics and antithrombotic agents.Type: GrantFiled: September 17, 1982Date of Patent: March 20, 1984Assignee: Glaxo Group LimitedInventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis, John Bradshaw
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Patent number: 4417012Abstract: Additives for rubber compositions, giving vulcanisates having improved retention of optimum physical properties, are compounds containing two or more groups of the formula --S--SO.sub.2 R linked by an organic bridging group, or polymers containing two or more groups of the formula --S--SO.sub.2 R attached to an organic polymer chain, where R represents (a) a radical OM where M is a monovalent metal, the equivalent of a multivalent metal, a monovalent ion derived by the addition of a proton to a nitrogenous base, or the equivalent of a multivalent ion derived by the addition of two or more protons to a nitrogenous base, or (b) an organic radical selected from aliphatic, cycloaliphatic, aromatic and heterocyclic radicals, and radicals which are combinations of any two or more such radicals.Type: GrantFiled: June 30, 1982Date of Patent: November 22, 1983Assignee: Monsanto Europe S.A.Inventor: Philippe G. Moniotte
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Patent number: 4385192Abstract: A process for manufacturing 1,2-dibromo-3-chloropropane is disclosed. The process comprises the steps of reacting bromine and allyl chloride at a temperature of from 5.degree. to 85.degree. C. and maintaining the reaction mixture between 60.degree. to 90.degree. C. for a sufficient length of time so as to permit the reaction between the bromine and allyl chloride to go to completion. In addition, the process also includes the step of adding an agent so as to stabilize and purify the product so formed.Type: GrantFiled: July 5, 1978Date of Patent: May 24, 1983Assignee: AMVAC Chemical CorporationInventors: Lester Friedman, Chester Callaway
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Patent number: 4376776Abstract: Dibenzofuran derivatives of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, X, A, Y, m, n, p and q have the meanings given in the description, and their use for controlling fungi.Type: GrantFiled: January 26, 1982Date of Patent: March 15, 1983Assignee: BASF AktiengesellschaftInventors: Costin Rentzea, Karl-Heinz Feuerherd, Bernd Zeeh, Hubert Sauter, Ernst-Heinrich Pommer
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Patent number: 4369206Abstract: This invention relates to new ammonium salts of .alpha.-ketocarboxylic acids, to their use for the production of amines in situ by photochemical decomposition and to photochemically hardenable coating compositions containing these ammonium salts.Type: GrantFiled: July 2, 1979Date of Patent: January 18, 1983Assignee: Bayer AktiengesellschaftInventors: Wofram Mayer, Hans Rudolph, Eckhard de Cleur, Manfred Schonfelder
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Patent number: 4366076Abstract: Corrosion-inhibited compositions are described comprising a functional fluid in contact with a ferrous metal and, as corrosion inhibitor, a compound having the formula: ##STR1## wherein X is H, an alkali- or alkaline earth metal, NH.sub.4, the residue of a protonated amine, or the group --OX is the residue of an alkanol having from 1 to 20 carbon atoms or of di-, tri- or tetra-ol having from 2 to 12 carbon atoms; R.sup.1, R.sup.2 and R.sup.4 are the same or different and each is H or --CH.sub.2 CH.sub.2 COOX wherein X has its previous meaning; R.sup.3 and R.sup.5 are the same or different and each is H, --CH.sub.2 CH.sub.2 COOX wherein X has its previous meaning, or R.sup.3 or R.sup.5 is a straight- or branched chain alkyl group having from 3 to 16 carbon atoms; or R.sup.3 and R.sup.5, together with the carbon atom to which they are each attached, may form a cycloalkanone ring containing from 5 to 15 carbon atoms.Type: GrantFiled: May 28, 1981Date of Patent: December 28, 1982Assignee: Ciba-Geigy CorporationInventor: David R. Clark
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Patent number: 4360465Abstract: New, quaternary ammonium salts of .alpha.-aminoacetanilides of secondary anilines having a good biological action, agents for regulating plant growth containing these ammonium salts, and the use of .alpha.-aminoacetanilides of secondary anilines for manufacturing the new salts.Type: GrantFiled: March 24, 1980Date of Patent: November 23, 1982Assignee: BASF AktiengesellschaftInventors: Ernst Buschmann, Ulrich Schirmer, Bernd Zeeh, Hubert Sauter, Johann Jung
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Patent number: 4342690Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.Type: GrantFiled: March 11, 1981Date of Patent: August 3, 1982Assignee: American Cyanamid CompanyInventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
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Patent number: 4342756Abstract: Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CH.dbd.CH--;R.sup.1 is C.sub.1-7 alkyl terminated by --COOR.sup.3 where R.sup.3 is H, C.sub.1-6 alkyl or C.sub.7-10 aralkyl;Y is a saturated heterocyclic amino group having 5-8 ring members; andR.sup.2 is C.sub.2-4 alkanoyl, C.sub.3-6 alkenyl (optionally substituted), C.sub.1-12 alkyl, or substituted or unsubstituted phenylalkyl, biphenylalkyl or naphthylalkyl.These compounds inhibit blood platelet aggregation and bronchoconstriction and may be formulated for use as antithrombotic and anti-asthmatic agents.Type: GrantFiled: April 29, 1981Date of Patent: August 3, 1982Assignee: Glaxo Group LimitedInventors: Eric W. Collington, Peter Hallett, Christopher J. Wallis, John Bradshaw, Norman F. Hayes
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Patent number: 4342689Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.Type: GrantFiled: March 11, 1981Date of Patent: August 3, 1982Assignee: American Cyanamid CompanyInventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
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Patent number: 4342691Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.Type: GrantFiled: March 11, 1981Date of Patent: August 3, 1982Assignee: American Cyanamid CompanyInventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
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Patent number: 4328202Abstract: Ionic compounds of the formula ##STR1## wherein X is --CONR.sub.1 R.sub.2, --CH.sub.2 NH.multidot.Acyl or --CH.sub.2 OH; Y is --NR.sub.3 R.sub.4, --NH.multidot.Acyl or OR.sub.5 ; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 can be identical or different, and each is hydrogen, C.sub.1-6 - alkyl or C.sub.2-8 -alkyl substituted by 1-5 OH groups and/or by one C.sub.1-3 -alkoxy group, R.sub.5 is C.sub.1-6 alkyl or C.sub.2-8 -alkyl substituted by 1-5 OH groups and/or by one C.sub.1-3 -alkoxy group, and Acyl, which can be the same or different in X and Y, is C.sub.2-6 -alkanoyl or C.sub.2-6 -alkanoyl substituted by 1-4 OH groups and/or by one C.sub.1-3 -alkoxy group, or a physiologically compatible salt thereof with an inorganic or organic base, have valuable properties as X-ray contrast agents.Type: GrantFiled: January 9, 1981Date of Patent: May 4, 1982Assignee: Schering, A.G.Inventors: Heinz Gries, Heinrich Pfeiffer, Ulrich Speck, Wolfgang Muetzel
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Patent number: 4301186Abstract: This invention relates to new ammonium salts of .alpha.-ketocarboxylic acids, to their use for the production of amines in situ by photochemical decomposition and to photochemically hardenable coating compositions containing these ammonium salts.Type: GrantFiled: June 28, 1979Date of Patent: November 17, 1981Assignee: Bayer AktiengesellschaftInventors: Wolfram Mayer, Hans Rudolph, Eckhard De Cleur, Manfred Schonfelder
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Patent number: 4296129Abstract: Certain new propenamides and 2-butenamides having a (carboxyalkanamido)phenyl or a (carboxyalkenamido)phenyl group at the 3-position, and certain esters thereof, and their use for antagonizing the spasmogenic activity of slow-reacting substance of anaphylaxis (SRS-A) in a human subject. In particular, the compounds of the invention are useful for preventing and treating certain obstructive airways diseases, notably allergic bronchial asthma, allergic rhinitis and certain skin disorders, in human subjects.Type: GrantFiled: October 29, 1980Date of Patent: October 20, 1981Assignee: Pfizer, Inc.Inventor: Saul B. Kadin
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Patent number: 4247715Abstract: Indanyloxy compounds having 2-alkynyl substituents which exhibit diuretic, saluretic, and uricosuric activity are described. The compounds are obtained according to a process involving selective etherification of a 5-hydroxyindanone followed by alkynylation with a silylated alkynyl bromide to provide novel silylated intermediates which are hydrolyzed to indanyloxy compounds such as (6,7-dichloro-1-oxo-2-phenyl-2-propargyl-5-indanyloxy)acetic acid.Type: GrantFiled: April 9, 1979Date of Patent: January 27, 1981Assignee: Mead Johnson & CompanyInventors: Porter C. Johnson, William L. Matier
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Patent number: 4211551Abstract: Herbicidal compositions for selective weed control comprising 4-(4'-chlorobenzyl)-phenoxy acetic acid or a salt thereof and the novel salts of 4-(4'-chlorobenzyl)-phenoxy acetic acid.A method for selectively controlling weeds by applying to a crop area an effective amount of 4-(4'-chlorobenzyl)-phenoxy acetic acid or a salt of said acid.Type: GrantFiled: November 10, 1977Date of Patent: July 8, 1980Assignee: Siegfried AGInventors: Kurt Thiele, Quazi Ahmed, Walter Scharen, Jacques Meyer
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Patent number: 4197312Abstract: This disclosure describes new compounds and compositions of matter useful as anti-inflammatory agents and as inhibitors of the progressive joint deterioration characteristic of arthritic disease and the methods of meliorating inflammation and of inhibiting joint deterioration in mammals therewith, the novel active ingredients of said compositions of matter being the pharmacologically acceptable cationic salts of benzoylacetonitrile, o-fluorobenzoylacetonitrile, m-fluorobenzoylacetonitrile, p-fluorobenzoylacetonitrile, or mixtures thereof.Type: GrantFiled: May 9, 1978Date of Patent: April 8, 1980Assignee: American Cyanamid CompanyInventors: Adolph E. Sloboda, John W. Hanifin, Jr.
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Patent number: 4161538Abstract: 4-(2-Oxo- or hydroxyimino-cycloalkan-1-ylmethyl)phenylacetic acid derivative and nontoxic pharmaceutically acceptable salt thereof are useful as an anti-inflammatory agent. The above 2-oxo-compound may be prepared by (a) hydrolyzing and decarboxylating 4-(1-alkoxycarbonyl-2-oxocycloalkan-1-ylmethyl)phenylacetic acid ester derivative or (b) reacting p-halomethylphenylacetic acid ester derivative with an enamine of cycloalkanone and hydrolyzing the resulting product. And further, the above 2-hydroxyimino-compound may be prepared by (c) reacting 4-(2-oxocycloalkan-1-ylmethyl)phenylacetic acid derivative (the product of process (a) or (b)) with hydroxylamine or (d) reacting a dilithium salt of cycloalkanone oxime with p-halomethyl- or p-sulfonyloxymethyl-phenylacetic acid ester derivative and hydrolyzing the resulting product.Type: GrantFiled: March 10, 1978Date of Patent: July 17, 1979Assignee: Sankyo Company LimitedInventors: Atsusuke Terada, Kazuyuki Wachi, Eiichi Misaka
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Patent number: 4152915Abstract: Halogenated polycondensates of fatty alcohol-acids are prepared by the following steps:A. polycondensation of said fatty alcohol-acid in a solvent,B. halogenation of the polycondensate obtained in step (a)C. salification of the halogenated polycondensate obtained in step (b) by an alkaline and/or an amine and/or ammonium base.The polycondensates may also be esterifired with a mineral acid.The products are used in aqueous solutions for metal working.Type: GrantFiled: June 14, 1978Date of Patent: May 8, 1979Assignee: Aquila S.p.A.Inventors: Giancarlo Bussi, Pierpaolo Baradel
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Patent number: 4152515Abstract: There are disclosed herein novel builder salts of alkyloxysuccinic acids, alkyloxyhydroxysuccinic acids, alkylthiosuccinic acids, alkylthiohydroxysuccinic acids, and the sulfoxide and sulfone derivatives of the alkylthiosuccinic and alkylthiohydroxysuccinic acids. The new builder compounds can be generally represented as follows: ##STR1## wherein Z is selected from the group consisting of O, S, SO and SO.sub.2 ; X is H or OH; R is an alkyl radical containing from 6 to 30 carbon atoms and M is selected from the group consisting of alkali metal cations, ammonium and substituted ammonium. These new builder compounds can be substituted in detergent compositions for existing builders containing phosphorous or nitrogen without impairing and in some cases improving the efficiency of such detergent compositions.Type: GrantFiled: April 13, 1977Date of Patent: May 1, 1979Assignee: Lever Brothers CompanyInventors: Vincent Lamberti, Mark D. Konort
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Patent number: 4137409Abstract: Carboxymethyloxysuccinic anhydrides and/or halides, their reaction products with active hydrogen compounds and methods for preparing the anhydrides, the halides and the reaction products are disclosed. The reaction products are variously useful in the fields of food flavorings, detergent builders, surfactants, lubricants, coatings, sizing agents and gasoline additives.Type: GrantFiled: April 4, 1978Date of Patent: January 30, 1979Assignee: Lever Brothers CompanyInventor: Vincent Lamberti
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Patent number: 4122200Abstract: Propionic acids and their functional derivatives having anti-inflammatory and analgesic properties correspond to the formula ##STR1## in which X is selected from phenyl, halophenyl, polyhalophenyl, lower alkylphenyl, trihalomethylphenyl, aryloxyphenyl, furyl and thienyl and R is selected from hydrogen, lower alkyl, lower omega-hydroxyalkyl, morpholinoethyl and lower dialkylaminoalkyl.Type: GrantFiled: August 9, 1977Date of Patent: October 24, 1978Assignee: Lipha, Lyonnaise Industrielle PharmaceutiqueInventors: Philippe Briet, Jean-Jacques Berthelon, Jean-Claude Depin, Eugene Boschetti
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Patent number: 4107434Abstract: Novel process for the production of antibacterially active pleuromutilin derivatives.Type: GrantFiled: January 10, 1977Date of Patent: August 15, 1978Assignee: Sandoz Ltd.Inventor: Erwin Waldvogel
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Patent number: 4101671Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or aliphatic or aromatic carboxylic acyl,R.sub.2 is hydrogen, chlorine or bromine,R.sub.3 is fluorine, alkyl of 1 to 4 carbon atoms, trifluoromethyl, cyano, carbamoyl, carboxyl, carbalkoxy, alkoxy, acetyl, 1-hydroxyethyl or ##STR2## where R.sub.6 and R.sub.7 are each alkyl, cycloalkyl, hydroxy-cycloalkyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino or morpholino, andR.sub.4 and R.sub.5 are each hydrogen, alkyl of 1 to 5 carbon atoms, mono- or di-hydroxy (alkyl of 1 to 5 carbon atoms), alkenyl of 2 to 4 carbon atoms, cycloalkyl of 5 to 7 carbon atoms, mono- or di-hydroxy (cycloalkyl of 5 to 7 carbon atoms), benzyl, morpholinocarbonylmethyl or, together with each other and the nitrogen atom to which they are attached, pyrrolidino, piperidino, hexamethyleneimino, morpholino, N-methyl-piperazino or camphidino,Provided, however, that when R.sub.3 is carboxyl or carbalkoxy, R.sub.4 and R.sub.Type: GrantFiled: March 24, 1977Date of Patent: July 18, 1978Assignee: Boehringer Ingelheim GmbHInventors: Johannes Keck, Klaus-Reinhold Noll, Helmut Pieper, Gerd Kruger, Sigfrid Puschmann
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Patent number: 4093634Abstract: Carboxymethyloxysuccinic anhydrides and/or halides, their reaction products with active hydrogen compounds and methods for preparing the anhydrides, the halides and the reaction products are disclosed. The reaction products are variously useful in the fields of food flavorings, detergent builders, surfactants, lubricants, coatings, sizing agents and gasoline additives.Type: GrantFiled: May 16, 1977Date of Patent: June 6, 1978Assignee: Lever Brothers CompanyInventors: Vincent Lamberti, Eddie Nelson Gutierrez
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Patent number: 4093631Abstract: Compounds of the formula (I): ##STR1## and salts thereof wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or benzyl; R.sub.2 is hydrogen or alkyl of 1 to 4 carbon atoms or is joined to R.sub.1 so that the NR.sub.1 R.sub.2 moiety is a 5-, 6- or 7-membered saturated heterocyclic ring; R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms or acyl of 1 to 4 carbon atoms; R.sub.4 is an aromatic group; R.sub.5 is hydrogen or alkyl of 1 to 4 carbon atoms R.sub.6 is hydrogen or alkyl of 1 to 4 carbon atoms; X is --CH.sub.2 -- or an oxygen atom and the dotted line represents a single or double bond, are useful for inducing anorexia and for their mood-modifying effects.Type: GrantFiled: June 1, 1976Date of Patent: June 6, 1978Assignee: Beecham Group LimitedInventor: Derek Victor Gardner
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Patent number: 4087526Abstract: This invention is concerned with (3-amino-5-substituted-6-fluoropyrazinoyl or pyrazinamido)guanidine compounds and derivatives thereof bearing substituents on the guanidine nitrogens. These compounds possess useful natriuretic properties. Also included are processes for preparing these compounds and a novel intermediate used in the preparation of these compounds.Type: GrantFiled: July 23, 1976Date of Patent: May 2, 1978Assignee: Merck & Co., Inc.Inventors: Edward J. Cragoe, Jr., Otto W. Woltersdorf, Jr.
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Patent number: 4077956Abstract: New 5-substituted derivatives of dipyrazolo[1,5-a:4',3'-e]pyrazine-6-carboxylic acid, esters and their salts have the formula ##STR1## R.sup.1 is hydrogen, lower alkyl or phenyl-lower alkylene; R.sup.2 and R.sup.3 each is hydrogen or lower alkyl; X is oxygen or sulfur; and R.sup.4 is hydrogen, lower alkyl, phenyl-lower alkylene or amino-lower alkylene.The new compounds are useful as anti-inflammatory agents and immunosuppressive agents.Type: GrantFiled: August 30, 1976Date of Patent: March 7, 1978Assignee: E. R. Squibb & Sons, Inc.Inventor: Uwe D. Treuner
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Patent number: 4075223Abstract: Derivatives of 2-aroyl-3-phenylindenes, 3-aroyl-4-phenyl-1,2-dihydronaphthalenes, and 1-phenyl-2-aroyl-naphthalenes are useful as antifertility agents.Type: GrantFiled: November 24, 1976Date of Patent: February 21, 1978Assignee: Eli Lilly and CompanyInventors: Tulio Suarez, C. David Jones
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Patent number: 4062955Abstract: Compounds of the general formula: ##STR1## wherein the groups CHR.sup.1 NR.sup.2 R.sup.3 and CHR.sup.4 NR.sup.5 R.sup.6 may be the same or different and where the group CHR.sup.4 NR.sup.5 R.sup.6 is in either the 1 or the 3 position and R.sup.1 and R.sup.4 independently represent a hydrogen atom or an aryl group;R.sup.2, r.sup.3, r.sup.5 and R.sup.6 which may be the same or different are each a hydrogen atom or an alkyl group or an aryl group both of which may in turn be substituted by one or more hydroxy, alkoxy, acyloxy, dialkylamino or aryl groups or the groups --NR.sup.2 R.sup.3 and/or NR.sup.5 R.sup.6 represent a heterocyclic ring containing one or more hetero atoms and which ring may optionally be substituted by an alkyl, aryl or aralkyl group and in which either aromatic ring of the naphthalene nucleus may be further substituted; with the proviso that when R.sup.1, R.sup.4, R.sup.2 and R.sup.5 are hydrogen, then R.sup.3 and R.sup.Type: GrantFiled: October 28, 1975Date of Patent: December 13, 1977Assignee: Glaxo Laboratories LimitedInventors: Derek Burn, Richard J. Coles
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Patent number: 4062669Abstract: This disclosure relates to N-organo-N-phosphonomethylglycine-N-oxides and derivatives thereof, to processes for producing same, and to herbicidal compositions and herbicidal methods. These compounds and the compositions containing them are useful as phytotoxicants or herbicides and as plant growth regulants.Type: GrantFiled: September 15, 1975Date of Patent: December 13, 1977Assignee: Monsanto CompanyInventor: John E. Franz
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Patent number: 4056531Abstract: High molecular weight N-hydrocarbyl-substituted quaternary ammonium salts in which the hydrocarbyl group has a molecular weight of from about 350-3000 such as a polybutene ammonium chloride are effective detergents and dispersants for gasoline and lubricating oils.Type: GrantFiled: September 15, 1975Date of Patent: November 1, 1977Assignee: Ethyl CorporationInventor: Robert E. Malec
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Patent number: 4042584Abstract: This application discloses arylethynylphenylcyclopropylamines and processes for their preparation. These amines exhibit monoamine oxidase (MAO) inhibiting activity.Type: GrantFiled: April 8, 1975Date of Patent: August 16, 1977Assignee: Merck & Co., Inc.Inventor: David C. Remy