Acridines (including Hydrogenated) Patents (Class 546/102)
  • Patent number: 10642119
    Abstract: An electrochromic compound represented by the following formula (I) is provided: where each of R1 to R8 and R11 to R18 independently represents any one of a hydrogen atom, a halogen atom, a monovalent organic group, the monovalent organic group having a substituent, a polymerizable functional group, and the polymerizable functional group having a substituent; and each of R9, R10, R19, and R20 independently represents any one of a hydrogen atom, an alkyl group, and an aryl group.
    Type: Grant
    Filed: May 3, 2017
    Date of Patent: May 5, 2020
    Assignee: Ricoh Company, Ltd.
    Inventors: Satoshi Yamamoto, Toshiya Sagisaka, Masato Shinoda, Daisuke Goto
  • Patent number: 9624539
    Abstract: This invention provides nucleoside triphosphate analogs having the structure: wherein B is a base and is adenine, guanine, cytosine, uracil or thymine, wherein R? is an OH or an H, and wherein R? is azidomethyl, a hydrocarbyl, or a substituted hydrocarbyl, and which has a Raman spectroscopy peak with wavenumber from 2000 cm?1 to 2300 cm?1 or a Fourier transform-infrared spectroscopy spectroscopy peak with wavenumber from 2000 cm?1 to 2300 cm?1, and also to methods of DNA sequencing and SNP detection.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: April 18, 2017
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Jingyue Ju, Jian Wu, Zengmin Li
  • Patent number: 9512080
    Abstract: A method is provided for N-alkylation of acridine compounds by reduction of acridines to corresponding acridans to improve the reactivity of the acridine nitrogen, and subsequent N-alkylation of the acridans in ionic liquid solvents to provide the corresponding acridinium compounds in high yield. This inventive process improves chemical conversion, and does not require the use of highly toxic alkylating agents, such as 1,3-propane sultone.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: December 6, 2016
    Assignee: SIEMENS HEALTHCARE DIAGNOSTICS INC.
    Inventors: Anand Natrajan, David Wen
  • Patent number: 9493421
    Abstract: The present invention relates to a compound of general formula (I) in which: —R1 and R2 are simultaneously or independently H, OH, OCH3 or a C1-C5 alkyl radical, —R3 and R4 are simultaneously CH3, —or R3 is H and R4 is CH3, CH2CH3 or an isopropyl radical or a phenyl radical, —R5 is a C4-C24 alkyl radical or a 3-phenylpropanyl or 2,2-diphenylethanyl radical.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: November 15, 2016
    Assignee: PIERRE FABRE DERMO COSMETIQUE
    Inventors: Stéphane Poigny, Françoise Belaubre
  • Publication number: 20150141642
    Abstract: A light-emitting material containing a compound represented by the following general formula in a light-emitting layer has high light emission efficiency. In the following general formula, R1 to R10 represent a hydrogen atom or a substituent, provided that at least one of R1 to R10 represents an aryl group, a diarylamino group or a 9-carbazolyl group.
    Type: Application
    Filed: March 15, 2013
    Publication date: May 21, 2015
    Applicant: KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Chihaya Adachi, QiSheng Zhang, Kei Sakanoue, Shuzo Hirata
  • Patent number: 9000171
    Abstract: An organic electroluminescence (EL) material and an organic EL device, the organic EL material being represented by Formula 1, below:
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: April 7, 2015
    Assignee: Samsung Display Co., Ltd.
    Inventor: Hiroaki Itoi
  • Publication number: 20150060803
    Abstract: An organic compound with characteristics excelling in hole-injecting/transporting performance and having an electron blocking ability, a highly stable thin-film state, and excellent heat resistance is provided as material for an organic electroluminescent device of high efficiency and high durability, and the organic electroluminescent device of high efficiency and high durability is provided using this compound. The compound of a general formula (Chemical Formula 1) having an acridan ring structure is used as a constituent material of at least one organic layer in the organic electroluminescent device that includes a pair of electrodes and one or more organic layers sandwiched between the pair of electrodes.
    Type: Application
    Filed: April 4, 2013
    Publication date: March 5, 2015
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Daizou Kanda, Naoaki Kabasawa, Shuichi Hayashi
  • Publication number: 20150031889
    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent, an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.
    Type: Application
    Filed: August 14, 2014
    Publication date: January 29, 2015
    Inventors: Brij Pal Giri, Dinesh J. Dagli, Pritam Singh
  • Patent number: 8937121
    Abstract: A condensed heterocyclic compound which is shown by the following formula (I) and a composition containing an (a) organic material and (b) at least one type of the condensed heterocyclic compound are provided. (Y indicates a chemical single bond, —S(?O)—, or —SO2—. Ra and Rb indicate substitutable C1 to C30 organic groups. Za and Zb indicate chemical single bonds or —SO2—. X1 and X2 indicate hydrogen atoms etc. n and m respectively independently indicate integers of 0 to 2, where one of n and m is not 0).
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: January 20, 2015
    Assignee: Zeon Corporation
    Inventors: Kei Sakamoto, Satoshi Kiriki, Tomonori Ogawa, Masanobu Shinohara
  • Publication number: 20140349297
    Abstract: The present invention relates to fluorescent dyes based on acridine and acridinium derivatives and use of such dyes in for example, biochemical and/or cell-based assays.
    Type: Application
    Filed: December 20, 2012
    Publication date: November 27, 2014
    Applicant: Almac Sciences (Scotland) Limited
    Inventors: Beatrice Maltman, Adina-Elena Tirnaveanu, Graham Cotton
  • Publication number: 20140348768
    Abstract: The present invention relates to a compound of general formula (I) in which: —R1 and R2 are simultaneously or independently H, OH, OCH3 or a C1-C5 alkyl radical, —R3 and R4 are simultaneously CH3, —or R3 is H and R4 is CH3, CH2CH3 or an isopropyl radical or a phenyl radical, —R5 is a C4-C24 alkyl radical or a 3-phenylpropanyl or 2,2-diphenylethanyl radical.
    Type: Application
    Filed: December 21, 2012
    Publication date: November 27, 2014
    Inventors: Stéphane Poigny, Françoise Belaubre
  • Publication number: 20140309244
    Abstract: The present invention provides compounds of formula (I) wherein R1, R2, A, X, D1, D2 and Y3 are as defined in the claims. The invention further provides intermediates used in the preparation of these compounds, to compositions which comprise these compounds and to their use in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
    Type: Application
    Filed: September 23, 2011
    Publication date: October 16, 2014
    Applicant: SYNGENTA PARTICIPATIONS AG
    Inventors: Werner Zambach, Daniel Stierli, Kurt Nebel, Andrea Bortolato, Clara Massol
  • Patent number: 8822233
    Abstract: New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are water-soluble acridanes, enhancer coupled acridanes, bis and tris-acridanes as well as acridane-1,2-dioxetanes. Among the new 1,2-dioxetanes are electron deficient group-containing dioxetanes and tethered bis-1,2-dioxetanes. The 1,2-dioxetanes are useful as substrates for various enzymes. The acridanes can be admixed with an oxidizing agent. an aqueous buffer and, optionally, a stabilizer to form a substrate or reagent formulation useful for assaying, inter alia, HRP.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: September 2, 2014
    Inventors: Brij Pal Giri, Dinesh Dagli, Pritam Singh
  • Publication number: 20140231713
    Abstract: Novel spirobifluorene compounds for light emitting devices where the spirobifluorene ring system comprises at least one acridine-type substituent.
    Type: Application
    Filed: September 24, 2012
    Publication date: August 21, 2014
    Inventors: Dominique Bascour, Jonathan Maunoury, Enrico Orselli
  • Patent number: 8796917
    Abstract: A compound for an organic optoelectronic device, an organic light emitting diode, and a display device, the compound being represented by the following Chemical Formula 1:
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: August 5, 2014
    Assignee: Cheil Industries, Inc
    Inventors: Dong-Min Kang, Myeong-Soon Kang, Nam-Soo Kim, Chang-Ju Shin, Nam-Heon Lee, Ho-Kuk Jung, Mi-Young Chae
  • Patent number: 8779136
    Abstract: The present invention provides novel ruthenium based catalysts, and a process for preparing amines, by reacting a primary alcohol and ammonia in the presence of such catalysts, to generate the amine and water. According to the process of the invention, primary alcohols react directly with ammonia to produce primary amines and water in high yields and high turnover numbers. This reaction is catalyzed by novel ruthenium complexes, which are preferably composed of quinolinyl or acridinyl based pincer ligands.
    Type: Grant
    Filed: October 18, 2013
    Date of Patent: July 15, 2014
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: David Milstein, Chidambaram Gunanathan
  • Patent number: 8753641
    Abstract: The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of complexing a metal, which metal is preferably a radioactive metal, to the use of these molecules and to therapeutic and diagnostic compositions containing them.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: June 17, 2014
    Assignee: University of Zurich
    Inventors: Roger Ariel Alberto, Pascal Jean-Marie Hafliger
  • Patent number: 8729267
    Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: May 20, 2014
    Assignee: Applied Biosystems, LLC
    Inventors: Ronald Graham, Ruiming Zou, Krishna G. Upadhya, Scott C. Benson
  • Publication number: 20140061548
    Abstract: The present invention relates to a compound of the formula (I), to the use of the compound in an electronic device, and to an electronic device comprising a compound of the formula (I). The present invention furthermore relates to a process for the preparation of a compound of the formula (I) and to a formulation comprising one or more compounds of the formula (I).
    Type: Application
    Filed: April 14, 2012
    Publication date: March 6, 2014
    Applicant: Merck Patent CmbH
    Inventors: Elvira Montenegro, Arne Buesing, Frank Voges, Christof Pflumm
  • Publication number: 20140058099
    Abstract: The compounds represented fey the following general formula is is thermally stable and has excellent characteristics as a charge transport material [Ar1 represents a single bond, a benzene ring, etc.; X1 represents a linking group that links via an oxygen atom, a sulfur atom, a carbon atom, a nitrogen atom, a phosphorus atom or a silicon atom; either one of L1 and L2, and L3 and L4 bond to each other to represent a linking group that links via an oxygen atom, a sulfur atom, a carbon atom, a nitrogen atom, a phosphorus atom or a silicon atom; the other of L1 and L2, and L3 and L4 represent a hydrogen atom or a substituent; Y1 represents a linking group that links via a nitrogen atom, a boron atom or a phosphorus atom; R1, R2, R5 to R7 and R10 to R12 represent a hydrogen atom or a substituent; and n1 indicates an integer of 2 or more.].
    Type: Application
    Filed: March 2, 2012
    Publication date: February 27, 2014
    Applicant: KYUSHU UNIVERSITY NATIONAL UNIVERSITY CORPORATION
    Inventors: Atsushi Wakamiya, Hidetaka Nishimura, Yasujiro Murata, Tatsuya Fukushima, Hironori Kaji
  • Publication number: 20140042411
    Abstract: Provided is a method for purifying an organic material having a 10% weight reduction temperature of 250° C. or more as measured by thermogravimetry at a vacuum degree of 1×10?2 Pa or less, which may sublime and purify the organic material having high heat resistance at high sublimation temperature with high purity and high yield in a short period of time, in which the organic material is subjected sublimation purification after a concentration of inorganic impurities in the organic material is adjusted to 5,000 ppm or less.
    Type: Application
    Filed: October 7, 2013
    Publication date: February 13, 2014
    Applicant: FUJIFILM CORPORATION
    Inventor: Eiji FUKUZAKI
  • Publication number: 20140042425
    Abstract: An organic compound with characteristics excelling in hole-injecting/transporting performance and having an electron blocking ability, a highly stable thin-film state, and excellent heat resistance is provided as material for an organic electroluminescent device of high efficiency and high durability, and the organic electroluminescent device of high efficiency and high durability is provided using this compound. The compound of a general formula (Chemical Formula 1) having a substituted acridan ring structure is used as a constituent material of at least one organic layer in the organic electroluminescent device that includes a pair of electrodes and one or more organic layers sandwiched between the pair of electrodes.
    Type: Application
    Filed: April 24, 2012
    Publication date: February 13, 2014
    Applicant: HODOGAYA CHEMICAL CO., LTD.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Naoaki Kabasawa, Eiji Takahashi
  • Patent number: 8632893
    Abstract: Organic compounds and organic electroluminescence devices employing the same are provided. The organic compound has a chemical structure represented as follows: wherein R are each independently an hydrogen, or a C1-8 alkyl group, and wherein R1 and R2 are each independently an hydrogen, or a C1-8 alkyl group, R3 is a hydrogen, and R1 and R2 are not hydrogen group simultaneously; or wherein R1 and R2 link together with the carbon atoms bonded thereto to form a phenyl group; wherein R2 and R3 link together with the carbon atoms bonded thereto to form a phenyl group.
    Type: Grant
    Filed: September 15, 2011
    Date of Patent: January 21, 2014
    Assignee: Industrial Technology Research Institute
    Inventors: Chi-Jen Lin, Heh-Lung Huang, Jin-Sheng Lin, Chien-Hong Cheng, Mei-Rurng Tseng
  • Patent number: 8630703
    Abstract: Hydrophobic weak base compounds such as hydrophobic weak base chemotherapeutic agents (which are not an anthracycline) for use in the treatment of medical conditions such as proliferative disease or disorder in a subject, in combination with illumination of a region in a body of the subject which is characterized by the presence of proliferating cells, are disclosed. The hydrophobic weak base compound and a wavelength of illumination are selected such that the hydrophobic weak base compound acts as a therapeutically effective photosensitizer when exposed to the illumination.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: January 14, 2014
    Assignee: Technion Research & Development Foundation Limited
    Inventors: Yehuda G. Assaraf, Yamit Adar Turgeman, Andrzej M. Skladanowski, Arjan W. Griffioen, Henk Verheul, Kristy Gotink, Hubert Van Den Bergh, Patrycja Nowak-Sliwinska
  • Publication number: 20140004051
    Abstract: The invention provides co-crystals and salts of contrast agents as well as methods to use and prepare the co-crystals and salts.
    Type: Application
    Filed: June 28, 2013
    Publication date: January 2, 2014
    Inventor: Leonard R. MacGillivray
  • Patent number: 8569502
    Abstract: Quaternary nitrogen heterocyclic boronic acid-containing compounds are described, which are sensitive to glucose and fructose, as well as a variety of other physiologically important analytes, such as aqueous chloride and iodide, and a method of using the compounds. Also disclosed is a contact lens doped with the quaternary nitrogen heterocyclic boronic acid-containing compound, and a method of using the doped contact lens to measure the concentration of analyte in tears under physiological conditions.
    Type: Grant
    Filed: December 24, 2012
    Date of Patent: October 29, 2013
    Inventors: Chris D. Geddes, Ramachandram Badugu, Joseph R. Lakowicz
  • Publication number: 20130256645
    Abstract: A compound for an organic optoelectronic device, an organic light emitting diode including the same, and a display device including the organic light emitting diode are disclosed, the compound being represented by the following Chemical Formula 1:
    Type: Application
    Filed: June 3, 2013
    Publication date: October 3, 2013
    Inventors: Soo-Hyun MIN, Eun-Sun YU, Hyung-Sun KIM, Mi-Young CHAE
  • Publication number: 20130225517
    Abstract: The invention provides compounds of formula I: or salts thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula I and therapeutic methods for treating cancer.
    Type: Application
    Filed: February 22, 2013
    Publication date: August 29, 2013
    Applicant: University of Iowa Research Foundation
    Inventor: University of Iowa Research Foundation
  • Publication number: 20130181202
    Abstract: There is provided a compound represented by a specific formula, which has an absorption maximum at 400 nm or more and less than 720 nm in a UV-visible absorption spectrum, wherein a molar extinction coefficient is 10,000 mol?1·l·cm?1 or more at the absorption maximum wavelength, and a difference between a melting point and a deposition temperature (a melting point?a deposition temperature) is 31° C. or more.
    Type: Application
    Filed: March 7, 2013
    Publication date: July 18, 2013
    Applicant: FUJIFILM CORPORATION
    Inventor: FUJIFILM CORPORATION
  • Publication number: 20130126856
    Abstract: An organic compound with excellent characteristics excelling in hole-injecting/transporting performance and having electron blocking ability, high stability in a thin-film state and high luminous efficiency is provided as material for an organic electroluminescent device. The compound of a general formula (1) having an indenocarbazole ring structure is used as a constituent material of at least one organic layer in the organic electroluminescent device that includes a pair of electrodes and one or more organic layers sandwiched between the pair of electrodes.
    Type: Application
    Filed: July 29, 2011
    Publication date: May 23, 2013
    Applicant: HODOGAYA CHEMICAL CO., LTD.
    Inventors: Norimasa Yokoyama, Makoto Nagaoka, Kazunori Togashi, Kouki Kase, Eiji Takahashi
  • Publication number: 20130102631
    Abstract: The present invention provides compounds of formula (I) wherein R1, A1, X, Y6, Y7, Y8, G1, G2, G3 and p are as defined in the claims. The invention further provides intermediates used in the preparation of these compounds, to compositions which comprise these compounds and to their use in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
    Type: Application
    Filed: June 29, 2011
    Publication date: April 25, 2013
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Kurt Nebel, Daniel Stierli, Werner Zambach, Andrea Bortolato
  • Patent number: 8384068
    Abstract: The present invention relates to the use of (hetero)aryl-substituted acridine derivatives as matrix materials in a light-emitting layer of organic light-emitting diodes (OLEDs) and/or in a blocking layer for electrons in organic light-emitting diodes. The present invention further relates to a light-emitting layer which comprises at least one emitter material and at least one matrix material, wherein the matrix material used is at least one (hetero)aryl-substituted acridine derivative, and to an organic light-emitting diode which comprises at least one inventive light-emitting layer, to an organic light-emitting diode which comprises at least one acridine derivative of the formula (I) in a blocking layer for electrons, and to a device selected from stationary and mobile visual display units and illumination units which comprise at least one inventive organic light-emitting diode.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: February 26, 2013
    Assignee: BASF SE
    Inventors: Klaus Kahle, Oliver Molt, Nicolle Langer, Christian Lennartz, Christian Schildknecht, Simon Nord, Evelyn Fuchs, Jens Rudolph
  • Publication number: 20120319052
    Abstract: The present invention relates to compounds of the formula (1) or (2) and to the use thereof in electronic devices, and to electronic devices which comprise these compounds. The invention furthermore relates to the preparation of the compounds of the formula (1) or (2) and to formulations comprising one or more compounds of the formula (1) or (2).
    Type: Application
    Filed: January 21, 2011
    Publication date: December 20, 2012
    Applicant: Merck Patent GmbH
    Inventors: Constanze Brocke, Christof Pflumm, Amir Hossain Parham, Rocco Fortte
  • Publication number: 20120280613
    Abstract: A compound for an organic optoelectronic device, an organic light emitting diode, and a display device, the compound being represented by the following Chemical Formula 1:
    Type: Application
    Filed: July 19, 2012
    Publication date: November 8, 2012
    Inventors: Dong-Min Kang, Myeong-Soon Kang, Nam-Soo Kim, Chang-Ju Shin, Nam-Heon Lee, Ho-Kuk Jung, Mi-Young Chae
  • Patent number: 8293908
    Abstract: A method is provided for N-alkylation of acridine compounds, typically with a 1,3- propane sultone alkylating reagent, in ionic liquid solvents to provide the corresponding acridinium compounds in high yield.
    Type: Grant
    Filed: November 18, 2008
    Date of Patent: October 23, 2012
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, David Wen
  • Patent number: 8173274
    Abstract: Organic compounds and organic electroluminescence devices employing the same are provided. The organic compound has a chemical structure represented as follows: wherein, R1 and R2 are independent and can be aryl, heteroaryl, cycloalkyl, hetero-cycloalkyl, or a cycloaliphatic group, or R1 and R2 link together with the carbon atoms to which they are attached to form a fused aryl, heteroaryl, cycloalkyl, hetero-cycloalkyl, or a cycloaliphatic group, and R3, R4, and R5 are independent and can be H, C1-8 alkyl, C1-8 alkoxy, C1-8 halo-alkyl, aryl, heteroaryl, cycloalkyl, hetero-cycloalkyl, or a cycloaliphatic group.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: May 8, 2012
    Assignee: Industrial Technology Research Institute
    Inventors: Chi-Jen Lin, Heh-Lung Huang, Jin-Sheng Lin, Chien-Hong Cheng, Mei-Rurng Tseng
  • Patent number: 8129532
    Abstract: Amino(oligo)thiophene dyes useful for studying the electrophysiology of organelles, cells, and tissues are described. Compared to previously known dyes, the amino(oligo)thiophene dyes exhibit improved (faster) response to membrane potential changes, as well as the ability to be excited by 1064 nanometer femtosecond pulses. Methods of preparing the amino( oligo )thiophene dyes are also described.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: March 6, 2012
    Assignee: The University of Connecticut
    Inventors: Leslie M. Loew, Ping Yan
  • Patent number: 8119422
    Abstract: Chemiluminescent acridinium esters are provided which are fast light emitting and hydrolytically stable. The chemiluminescent acridinium esters are useful labels in assays for detecting or quantifying analytes.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: February 21, 2012
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventors: Anand Natrajan, Qingping Jiang, David Sharpe
  • Patent number: 8110562
    Abstract: This invention provides nuclear hormone receptor binding compounds, compositions comprising the same and methods of uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, prostate cancer and/or diseases or disorders of bone and muscle.
    Type: Grant
    Filed: July 19, 2007
    Date of Patent: February 7, 2012
    Assignees: University of Tennessee Research Foundation, The Ohio State University Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Igor Rakov, Casey Bohl, Michael L. Mohler
  • Patent number: 8106203
    Abstract: Methods for generating chemiluminescence rapidly by reaction of at least one compound comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups with a peroxidase enzyme and a peroxide are disclosed. The chemiluminescence thus produced can be used as a detectable signal in assays for peroxidase enzymes or peroxide-producing enzymes and in assays employing enzyme-labeled specific binding pairs. Use of the methods provides rapid signal generation, achieving a plateau intensity in under one minute. The substrate can be provided in a composition which demonstrates unexpectedly long storage stability.
    Type: Grant
    Filed: June 2, 2009
    Date of Patent: January 31, 2012
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Renuka de Silva, Wenhua Xie
  • Publication number: 20120020893
    Abstract: The invention is directed to a probe-type imaging device useful to visualize interior surfaces, e.g., the lumen of blood vessels. Specifically, the probe-type device is particularly useful for direct tissue imaging in the presence or absence of molecular imaging agents.
    Type: Application
    Filed: October 4, 2011
    Publication date: January 26, 2012
    Inventors: David R. Elmaleh, Rick A. Rogers, Hjalmar Brismar
  • Publication number: 20110288292
    Abstract: The present invention relates to substituted benzo[c]phenanthrene derivatives and to the production and to the use thereof in electronic devices, and to the electronic devices themselves. The present invention relates in particular to benzo[c]phenanthrene derivatives substituted with at least one aromatic unit or at least one diarylamino unit.
    Type: Application
    Filed: December 22, 2009
    Publication date: November 24, 2011
    Applicant: Merck Patent GmbH
    Inventors: Amir H. Parham, Arne Buesing, Holger Heil, Philipp Stoessel
  • Publication number: 20110281907
    Abstract: Derivatives and analogs of inhibitors of receptor tyrosine kinase c-Met obtained by virtual screening, pharmaceutical compositions containing derivatives and analogs of c-Met inhibitors are provided. Methods of making derivatives and analogs of c-Met inhibitors and methods of use thereof are provided.
    Type: Application
    Filed: March 31, 2009
    Publication date: November 17, 2011
    Applicant: The Government of the United States of America, as represented by the Secretary, Dept.of Health and.
    Inventors: Donald P. Bottaro, Megan Peach, Marc Nicklaus, Nelly Tan
  • Patent number: 8057990
    Abstract: The present invention provides a medicament for preventing/treating cancer, comprising a tacrine compound, or a compound promoting the binding between the tacrine compound and a protein comprising the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1.
    Type: Grant
    Filed: March 7, 2006
    Date of Patent: November 15, 2011
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Masaaki Mori, Kimiko Kanehashi
  • Publication number: 20110263457
    Abstract: We describe herein a cell-based multiplexing technique called detectable cell barcoding (DCB). In DCB, each individual sample is labeled with a different DCB signature that distinguishes each sample by one or both of detected intensity or type of detection characteristic. The samples are then combined and analyzed for a detectable characteristic of interest (e.g., presence of an analyte). By employing multiple distinct DCB labels at varying concentrations, one can perform multiplex analyses on up to hundreds or thousands (or more) of cell samples in a single reaction tube. DCB reduces reagent consumption by factors of 100-fold or more, significantly reduces data acquisition times and allows for stringent control sample analysis.
    Type: Application
    Filed: July 1, 2011
    Publication date: October 27, 2011
    Inventors: Peter O. Krutzik, Garry Nolan
  • Publication number: 20110250699
    Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
    Type: Application
    Filed: June 21, 2011
    Publication date: October 13, 2011
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Ronald J. Graham, Ruiming Zou, Krishna G. Upadhya, Scott C. Benson
  • Patent number: 8034636
    Abstract: In accordance with the present invention, it has been discovered that introduction of hydrophilic sulfoalkyl substituents and/or hydrophilic linkers derived from homocysteic acid, cysteic acid, glycine peptides, tetraethylene oxide, and the like, offset the hydrophobicity of the acridinium ring system to produce a more soluble label which can be attached to an antibody at higher loading before precipitation and aggregation problems are encountered. Additional compounds described herein contain linkers derived from short peptides and tetraethylene oxide which increase aqueous solubility due to hydrogen bonding with water molecules. The present invention also embraces reagents for multiple acridinium labeling for signal amplification composed of a peptide bearing several acridinium esters with sulfonate groups at regularly spaced intervals for increased solubility. The invention also embraces assays employing the above-described compounds.
    Type: Grant
    Filed: September 23, 2010
    Date of Patent: October 11, 2011
    Assignee: Quest Diagnostics Investments Incorporated
    Inventors: Ramon Evangelista, Martha Garrity
  • Patent number: 8034944
    Abstract: There are provided a novel benzofluoranthene compound and an organic light-emitting device which uses the benzofluoranthene compound, gives a blue emission hue with extremely good purity, and has an optical output with a high efficiency, a high luminance, and a long life. Specifically, there are provided a benzofluoranthene compound represented by the general formula shown below and an organic light-emitting device including a pair of electrodes including an anode and a cathode one of which is a transparent or translucent electrode material, and an organic compound layer disposed between the pair of electrodes and including a material for an organic light-emitting device containing the benzofluoranthene compound. In the general formula (1), one of X1, X2, X3, X4, X5, and X6 represents a substituted or unsubstituted fused heterocyclic group having four or less rings, and the others of X1, X2, X3, X4, X5, and X6 each represent a hydrogen atom.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: October 11, 2011
    Assignee: Canon Kabushiki Kaisha
    Inventors: Hiroki Ohrui, Akihito Saitoh, Chika Negishi, Hironobu Iwawaki, Masanori Muratsubaki, Hiroyuki Tomono, Tetsuya Kosuge, Akihiro Senoo
  • Patent number: 7985602
    Abstract: The present teachings generally relate to fluorescent dyes, linkable forms of fluorescent dyes, energy transfer dyes, reagents labeled with fluorescent dyes and uses thereof.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: July 26, 2011
    Assignee: Applied Biosystems, LLC
    Inventors: Ronald J. Graham, Ruiming Zou, Krishna G. Upadhya, Scott C. Benson
  • Patent number: 7973030
    Abstract: A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: July 5, 2011
    Assignee: Asahi Kasei Pharma Corporation
    Inventors: Takehiko Sasahara, Mitsunobu Mohri, Ken-Ichi Kasahara