Patent number: 6410790
Abstract: 3-amino-3-arylpropan-1-ol compounds of formula I:
R1 and R2 independently denoting C1-6 alkyl, or together denoting a (CH2)2-6 ring optionally substituted by phenyl,
R3 denoting C3-6 alkyl, C3-6 cycloalkyl, aryl optionally containing heteroatoms and optionally substituted by R6 to R8, or a substituted C1-3 alkylphenyl of formula XII:
R4 and R5 independently denoting C1-6 alkyl, C3-6 cycloalkyl, phenyl, benzyl, or phenethyl, or together forming a (CH2)3-6 or CH2CH2OCH2CH2 ring,
R6 to R8 independently denoting H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR14, NR15R16, SR14, phenyl, SO2CH3, SO2CF3, C1-6 alkyl, CN, COOR14, or CONR15R16, or together forming a OCH2O, OCH2CH2O, CH═CHO, CH═C(CH3)O or (CH2)4 ring,
R14 denoting C1-6 alkyl, phenyl, benzyl, or phenethyl,
R15 and R16 independently denoting H, C1-6 alkyl, phenyl, benzyl or phenethyl, and
A denoting optionally substituted aryl optionally containing heteroatoms,
or a diastereomer or enantiomer or pharmaceutica
Type:
Grant
Filed:
April 7, 2000
Date of Patent:
June 25, 2002
Assignee:
Gruenenthal GmbH
Inventors:
Bernd Sundermann, Hagen-Heinrich Hennies, Babette-Yvonne Koegel, Helmut Buschmann
Patent number: 6218404
Abstract: The invention relates to subtype-selective NMDA receptor ligands and the use thereof for treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neuro-degenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease and Down's syndrome, treating or preventing the adverse consequences of the overstimulation of the excitatory amino acids, treating anxiety, psychosis, convulsions, aminoglycoside antibiotics-induced hearing loss, migraine headache, chronic pain, Parkinson's disease, glaucoma, CMV retinitis, urinary incontinence, opioid tolerance or withdrawal, and inducing anesthesia, as well as for enhancing cognition.
Type:
Grant
Filed:
September 16, 1998
Date of Patent:
April 17, 2001
Assignees:
Warner-Lambert Co., Cocensys, Inc.
Inventors:
Christopher F. Bigge, Gian Luca Araldi, Sui Xiong Cai, Anthony P. Guzikowski, Donald Lamunyon, Nancy F. Lan, Zhang-Lin Zhou, John F. W. Keana