The Ring Nitrogen Of The Six-membered Hetero Ring Is Pentavalent (e.g., Quaternary Pyridinium Salts, Etc.) Patents (Class 546/347)
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Patent number: 11121422Abstract: Ionic compounds containing an anion, and a cation having the following structural formula (1): R1R2R3N+-(linker1)-O-(linker2)-(FC)??(1) wherein: R1 and R2 either linear or branched alkyl groups or together form a N-heterocylic ring with the nitrogen atom to which they are joined; R3 is linear or branched alkyl group; linker1 and linker2 are alkylene chains or polyether chains; and the group FC is a fluorinated alkyl group, as well as an electrolyte material comprising such an ionic compound and a metal salt, and metal-air batteries using such an electrolyte material. The invention also relates to a metal-air battery containing an electrolyte material, wherein the electrolyte material comprises at least one ionic compound and a metal salt, and wherein at least one ionic compound contains an anion CnF2n+1COO? or CnF2n+1SO3?, where in each case n is at least 1 and at most 10.Type: GrantFiled: August 16, 2016Date of Patent: September 14, 2021Assignees: TOYOTA MOTOR EUROPE, KATHOLIEKE UNIVERSITEIT LEUVEN, K.U. LEUVEN R&DInventors: Fanny Barde, Gijs Vanhoutte, Sandra Dorota Hojniak-Thyssen, Koen Binnemans, Jan Fransaer
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Patent number: 10450329Abstract: A process for preparing a difluoro chelato borate salt comprising an anion A of formula (I) wherein is a bidentate radical derived from a 1,2-, 1,3- or 1,4-diol, from a 1,2-, 1,3- or 1,4-dicarboxylic acid or from a 1,2-, 1,3- or 1,4-hydroxycarboxylic acid by abstracting the two H atoms of pairs of adjacent OH groups of the respective diol, hydroxycarboxylic acid or dicarboxylic acid. The process includes step (i) reacting (a) one or more BF3 sources; (b) a dihydric compound selected from 1,2-, 1,3- and 1,4-diols, 1,2-, 1,3- and 1,4-dicarboxylic acids, and 1,2-, 1,3- and 1,4-hydroxycarboxylic acids; (c) one or more second boron sources which do not contain F; and (d) one or more proton acceptors.Type: GrantFiled: January 27, 2017Date of Patent: October 22, 2019Assignee: Gotion Inc.Inventors: Nicole Holub, Juergen Herbel
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Patent number: 10367227Abstract: An electrolyte composition and a metal-ion battery employing the same are provided. The electrolyte composition includes a metal chloride, a chlorine-containing ionic liquid, and an additive, wherein the additive has a structure represented by Formula (I) [M]i[(A(SO2CxF2x+1)y)b?]j??Formula (I), wherein M can be imidazolium cation, ammonium cation, azaannulenium cation, . . . etc., wherein M has a valence of a; a can be 1, 2, or 3; A can be N, O, Si, or C; x can be 1, 2, 3, 4, 5, or 6; y can be 1, 2, or 3; b can be 1, 2, or 3; i can be 1, 2, or 3; j can be 1, 2, or 3; a/b=j/i; and when y is 2 or 3, the (SO2CxF2x+1) moieties are the same or different.Type: GrantFiled: June 14, 2017Date of Patent: July 30, 2019Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Che-Wei Chang, Wen-Sheng Chang, Chun-Tsung Hsu, Yu-Wen Yeh, Tai-Feng Hung, Chang-Chung Yang
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Patent number: 10312551Abstract: The present invention relates to a preparation method of ionic liquids, particularly to a one-step reaction method used for synthesizing quaternary ammonium compounds or quaternary phosphonium compounds. In the method, a nitrogenous or phosphorous compound, a proton compound, and a carbonate ester are added into a reactor simultaneously to synthesize corresponding the quaternary ammonium ionic liquid or the quaternary phosphonium ionic liquid through said one-step reaction, i.e., ‘one-pot method’ reaction, during which three reactants are involved. The present invention also provides a lithium ion secondary battery comprising the ionic liquid prepared by above-mentioned preparation method. The ionic liquid preparation method of the present invention can widen the choice range of raw materials needed when preparing ionic liquids, and further widen the synthesized ionic liquid species.Type: GrantFiled: September 10, 2016Date of Patent: June 4, 2019Assignee: MICROVAST POWER SYSTEMS CO., LTD.Inventors: Zhuoqun Zheng, Dawei Shen, Jian Qiu, Yunhua Nie, Xiaozhen Zhao, Danyi Li
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Patent number: 9944878Abstract: The present invention relates to a lubricant and/or clean-out composition comprising: (a) a dispersant component comprising a succinimide dispersant and/or a quaternary ammonium salt dispersant; (b) a carrier fluid component; and (c) an optional corrosion inhibitor, as well as methods of cleaning out deposits in a lubricant system, such as a hydraulic system, using such compositions.Type: GrantFiled: October 14, 2010Date of Patent: April 17, 2018Assignee: The Lubrizol CorporationInventors: Betsy J. Butke, Grenville Holt
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Patent number: 9822063Abstract: The present invention refers to new solid forms of Enclomiphene citrate and Enclomiphene base, processes for preparing thereof and uses.Type: GrantFiled: October 26, 2015Date of Patent: November 21, 2017Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.AInventors: Pierluigi Padovan, Lorenzo Caruana, Nicolas Tesson
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Patent number: 9636298Abstract: The invention relates to prodrugs for use in the inhibition of histone deacetylase. The prodrugs of the present invention have good aqueous solubility and good aqueous stability. The prodrugs of the invention advantageously are metabolized to the active ingredient in plasma or in the blood stream of a warm-blooded animal. The invention also provides compositions and, and methods for making the prodrugs, and methods for using the prodrugs to treat fungal infections.Type: GrantFiled: January 15, 2015Date of Patent: May 2, 2017Inventors: Alain Ajamian, Yves Andre Chantigny, Arkadii Vaisburg, Franck Raeppel, Stephane Raeppel, Robert Deziel
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Patent number: 9593170Abstract: A compound that increases the photocuring rate of a photocurable composition and reduces the force for releasing a cured product from a mold is provided. A compound is represented by general formula (1): where Rf represents an alkyl group at least part of which is substituted with fluorine, RO represents an oxyalkylene group or a repeated structure of an oxyalkylene group, N represents a nitrogen atom, RA represents an alkyl group, and RB represents an alkyl group or a hydrogen atom.Type: GrantFiled: May 2, 2014Date of Patent: March 14, 2017Assignee: Canon Kabushiki KaishaInventors: Toshiki Ito, Takeshi Honma, Shiori Yonezawa, Hitoshi Sato, Youji Kawasaki
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Patent number: 9475997Abstract: Processes for removing sulfur and nitrogen contaminants from hydrocarbon streams are described. The processes include contacting the hydrocarbon stream comprising the contaminant with lean carbenium pseudo ionic liquid or a combination of carbenium pseudo ionic liquid and ionic liquid to produce a mixture comprising the hydrocarbon and rich carbenium pseudo ionic liquid or carbenium pseudo ionic liquid and ionic liquid comprising the contaminant. The mixture is separated to produce a hydrocarbon effluent and a rich carbenium pseudo ionic liquid or carbenium pseudo ionic liquid and ionic liquid effluent comprising the rich carbenium pseudo ionic liquid or carbenium pseudo ionic liquid and ionic liquid comprising the contaminant.Type: GrantFiled: November 24, 2014Date of Patent: October 25, 2016Assignee: UOP LLCInventors: Erin M. Broderick, Alakananda Bhattacharyya, Shurong Yang, Beckay J. Mezza
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Patent number: 9000180Abstract: In one form, processes for the production of certain N-substituted sulfoximine N-oxides are provided. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description.Type: GrantFiled: June 19, 2013Date of Patent: April 7, 2015Assignee: Dow AgroSciences LLCInventors: Douglas C. Bland, Ronald Ross, Jr., Peter L. Johnson, Timothy C. Johnson
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Publication number: 20150090639Abstract: Ionic liquids of the general formula C+A? where C+ represents an organic cation, specifically, but not limited to the imidazolium, pyridinium, isoquinolinium, ammonium types, which have aliphatic and aromatic substituents, while A? represents a carboxylate, aromatic and aliphatic anion. The ionic liquids are synthesized under conventional heating or microwave irradiation This invention is also related to the application of ionic liquids to remove sulfur compounds of naphthas through a liquid-liquid extraction and the recovery and reuse of ionic liquids by the application of heat, reduced pressure and washing with solvents.Type: ApplicationFiled: December 8, 2014Publication date: April 2, 2015Inventors: Rafael Martinez Palou, Natalya Victorovna Likhanova, Eugenio Alejandro Flores Oropeza, Diego Javier Guzman Lucero
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Patent number: 8946442Abstract: Foams of ionic compounds are described. Methods of making the foams are also provided. The foams are ionic and can be used for catalysis, separations, gas storage, biosensors, electronics, and electrochemical applications.Type: GrantFiled: December 21, 2010Date of Patent: February 3, 2015Assignee: E I du Pont de Nemours and CompanyInventors: Mark Brandon Shiflett, Akimichi Yokozeki
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Publication number: 20150027928Abstract: Methylcarbonate-based ionic liquids (LIs) or carboxylates, derived from aliphatic or aromatic carboxylic acids are provided for the extraction of nitrogen compounds from hydrocarbon mixture (HCs) by liquid-liquid selective extraction, at room temperature and atmospheric pressure, where the LIs are immiscible with the HCs. This process is performed through an extraction by stifling two phases, followed by separation, or in a continuous flow system where the nitrogenous compounds are transferred to the phase formed by the LI and the total nitrogen content is substantially reduced in the HCS phase. The ionic liquids have the general formula C+A?, where: C+ is a heterocyclic organic cation, or quaternary ammonium-based; and A? is a methylcarbonate- or carboxylates-based anion, derived from aliphatic or aromatic carboxylic acids.Type: ApplicationFiled: July 23, 2014Publication date: January 29, 2015Inventors: Natalya Victorovna LIKHANOVA, Rodolfo Juventino MORA VALLEJO, Georgina Cecilia LAREDO SANCHEZ, Irina Victorovna LIJANOVA, Bernando RODRIGUEZ HEREDIA
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Publication number: 20140377667Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.Type: ApplicationFiled: July 25, 2012Publication date: December 25, 2014Applicants: JACOBS UNIVERSITY BREMEN gGMBH, WESTFALISCHE WILHELMS UNIVERSITAT MUNSTERInventors: Gerd-Volker Roschenthaler, Martin Winter, Katja Vlasov, Nataliya Kalinovich, Christian Schreiner, Raphael Wilhelm Schmitz, Romek Ansgar Muller, Rene Schmitz, Alexandra Lex-Balducci, Miriam Kunze
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Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors
Publication number: 20140371266Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.Type: ApplicationFiled: August 27, 2014Publication date: December 18, 2014Inventors: Peter CROOKS, Linda P. DWOSKIN, Guangrong ZHENG, Sangeetha SUMITHRAN, Zhenfa ZHENG -
Patent number: 8907109Abstract: Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferatType: GrantFiled: January 11, 2013Date of Patent: December 9, 2014Assignees: Immunolight, LLC, Duke UniversityInventors: Eric Toone, David Gooden, Tuan Vo-Dinh, Frederic A. Bourke, Jr.
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Publication number: 20140348753Abstract: The development of a series of fluorescent materials including heterocycle-functionalized luminogens with aggregation-induced/enhanced emission (AIE/AEE), long wavelength emission, and high solid state fluorescence quantum efficiency is contemplated. The described fluorescent materials are promising candidates in selective luminescence-based chemosensor for Hg2+ or ATP, fluorescent staining for mitochondria in living cells with high photostability, stimuli-responsive luminescent materials, and materials for optical waveguides. In addition, these heterocycle-functionalized luminogens are particularly useful as fluorescent labels for biopolymers such as peptides, antibodies, or nucleic acids, making them useful as AIE-active biocompatible probes for clinical cancer imaging and diagnostics.Type: ApplicationFiled: May 24, 2013Publication date: November 27, 2014Inventors: Benzhong TANG, Wing Yip LAM, Na ZHAO, Min LI, Bin LIU, Haibin SHI, Dan DING
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Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
Patent number: 8846937Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.Type: GrantFiled: June 15, 2007Date of Patent: September 30, 2014Assignee: University of Kentucky Research FoundationInventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Zhenfa Zheng -
Patent number: 8841460Abstract: A compound, or a salt thereof, having the formula wherein Y is n is 1 or 2; each R is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl; R1 is H, lower alkyl or aralkyl; R2 is selected from H, acyl, aralkyl, phosphonyl, —SO2R3; —C(O)R5; —C(O)OR7 or —C(O)NR9R10; R3; R5; R7; R9 and R10 independently are selected from H, lower alkyl, aralkyl or aryl; and R20 is selected from alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl.Type: GrantFiled: December 14, 2012Date of Patent: September 23, 2014Assignee: State of Oregon Acting by and Through the State Board of Higher Education on Behalf of the University of OregonInventors: Darren W. Johnson, Calden Carroll, Michael M. Haley, Jeff Engle
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Publication number: 20140262818Abstract: A process for preparing an aqueous solution of N-ethyl-2-methylpyridinium bromide (2-MEPy), comprising reacting 2-picoline and ethyl bromide in a pressure reactor at a temperature above the melting point of the reaction mixture, combining the reaction product with water, wherein said reaction product consists essentially of 2-MEPy in a liquid form, and recovering an aqueous solution of 2-MEPy.Type: ApplicationFiled: March 20, 2014Publication date: September 18, 2014Applicant: BROMINE COMPOUNDS LTD.Inventors: Iris BEN-DAVID, Gershon MIASKOVSKI, Igor KOMPANIETS
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Publication number: 20140249059Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.Type: ApplicationFiled: May 14, 2014Publication date: September 4, 2014Inventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Giesleman, Christopher L. Friend, Patrick E. Mosier, Michele M. Rogers, Mark T. Tierney
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Patent number: 8821716Abstract: The present invention relates to an improved desulfurization process using an ionic liquid compound of general formula C+A?, where C+ represents an organic cation such as alkyl-pyridinium, di-alkyl imidazolium and tri-alkyl imidazolium; and A? is an anion of halides of iron (III), such as, for example, FeCl4?. The desulfurization process is also improved when producing the ionic liquid compound by heating the reactants using microwave energy. The ionic liquids can be used to desulfurize hydrocarbon mixtures by a liquid-liquid extraction.Type: GrantFiled: May 26, 2009Date of Patent: September 2, 2014Assignee: Instituto Mexicano del PetroleoInventors: Natalya Victorovna Likhanova, Rafael Martinez Palou, Jorge Froylan Palomeque Santiago
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Publication number: 20140243247Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.Type: ApplicationFiled: May 14, 2014Publication date: August 28, 2014Applicant: The Lubrizol CorporationInventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Giesleman, Christopher L. Friend, Patrick E. Mosier, Michele M. Rogers, Mark T. Tierney
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Patent number: 8796330Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.Type: GrantFiled: December 18, 2007Date of Patent: August 5, 2014Assignee: Methylgene Inc.Inventors: Robert Déziel, Alain Ajamian
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Patent number: 8785480Abstract: In one embodiment, processes for the preparation of certain functionalized pyridine N-oxides are provided. In one form, the functionalized pyridine N-oxides include 2-substituted-5-(1-alkylthio)alkyl-pyridine N-oxides. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description.Type: GrantFiled: June 13, 2013Date of Patent: July 22, 2014Assignee: Dow AgroSciences, LLC.Inventors: Douglas C. Bland, Ronald Ross, Jr., Peter L. Johnson, Timothy C. Johnson
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Patent number: 8754111Abstract: A method for the synthesis of N-substituted 3-acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine.Type: GrantFiled: July 18, 2013Date of Patent: June 17, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Peter Gebauer, Dieter Heindl, Carina Horn
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Patent number: 8735585Abstract: Disclosed is a compound of formula (I) and salts thereof. Also disclosed are methods of making the compound of formula (I) and the use of the compound as an intermediate for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.Type: GrantFiled: August 14, 2012Date of Patent: May 27, 2014Assignee: Boehringer Ingelheim International GmbHInventors: Bo Qu, Anjan Saha, Jolaine Savoie, Xudong Wei, Nathan K. Yee
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Patent number: 8728567Abstract: The present invention pertains to the double complex salts in optoelectronic components, like organic diodes, organic transistors or organic lasers, in particular an organic solar cell (OSC, OPP) and in particular from oligomers built from charged metal complexes.Type: GrantFiled: October 22, 2009Date of Patent: May 20, 2014Assignee: Cynora GmbHInventors: Hartmut Yersin, Tobias Fischer, Uwe Monkowius
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Patent number: 8669114Abstract: The subject of the invention at hand are novel, a little basic, fluorinated pentafluorophenyl imide anions, which can be used as anions in ionic liquids. Methods for producing ionic liquids are described, which contain these novel pentafluorophenyl imide ions as anions, as well as quaternary organic ammonium ions, guanidinium ions, N-organo-pyridinium ions, imidazolium, imidazolidinium or benzimidazolidinium ions, alkyl-alkylidene phosphoranes or aryl-alkylidene phosphoranes as cations. Alternative methods according to the present invention provide ionic liquids through reaction of ketene N,N-diacetals or alkyl or aryl-alkylidene phosphoranes with acids. The ionic liquids according to the present invention are suitable, for example, as solvents for syntheses, as mobile and/or stationary phase in chromatography, as electrolyte systems for batteries, galvanic elements, fuel cells and rechargeable battery packs.Type: GrantFiled: May 17, 2007Date of Patent: March 11, 2014Assignee: Philipps-Universitaet MarburgInventors: Jorg Sundermeyer, Thomas Linder
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Patent number: 8648202Abstract: The invention relates to bis(perfluoroalkyl)phosphinous acids, bis(perfluoroalkyl)thiophosphinous acids and derivatives, the synthesis thereof and the use thereof, in particular for the synthesis of air-stable metal complexes for catalytic processes.Type: GrantFiled: July 10, 2009Date of Patent: February 11, 2014Assignee: Merck Patent GmbHInventors: Berthold Hoge, Anne Julia Bader, Boris Kurscheid, Nikolai (Mykola) Ignatyev, Emil Ferdinand Aust
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Publication number: 20130288886Abstract: A method for preparing an ionic compound by mixing at least one compound of formula CxAy-zH2O (1) with at least one hydrogen donor and heating the mixture obtained is provided. The said ionic compound remains in a physical state selected from the group consisting of liquid and semisolid at a temperature below 150° C., preferably below 125° C.Type: ApplicationFiled: June 22, 2011Publication date: October 31, 2013Applicant: RELIANCE INDUSTRIES LTD.Inventors: Pavan Kumar Aduri, Parasuveera Uppara, Uday Ratnaparkhi, Mangesh Sakhalkar
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Publication number: 20130280555Abstract: A magnetic disk according to one embodiment of the present invention includes a base material and a lubricant layer provided on or over a base material. The lubricant layer contains a rod-like ionic liquid crystal compound having a cation group and an anion group.Type: ApplicationFiled: April 18, 2013Publication date: October 24, 2013Applicants: Samsung Electro-Mechanics Japan Advanced Technology Co., Ltd., UNIVERSITY OF YAMANASHIInventors: Yuichiro HARAMOTO, Mitsuo KODAMA
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Publication number: 20130102506Abstract: A lubricating base oil includes at least one of ionic liquids containing a compound represented by a formula (1): Z+A?, in which Z+ represents a cation and A? represents an anion, in which Z+ is a cyclic quaternary ammonium ion having two different side chains and A? is a conjugated amide ion.Type: ApplicationFiled: July 27, 2011Publication date: April 25, 2013Applicant: Idemitsu Kosan Co., Ltd.Inventors: Yukio Yoshida, Yukitoshi Fujinami
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Publication number: 20120330023Abstract: Alkylpyridinium dicyanamide of the formula: in which Rn1 is cyano or C1-20-alkyl and n is an integer from 0 to 3 and any R1 radicals present are the same or different, and in which R2 is C1-20-alkyl. There are processes for their preparation from alkylpyridinium halides and alkali metal dicyanamide, They can be used as polar solvents.Type: ApplicationFiled: April 6, 2005Publication date: December 27, 2012Applicant: LONZA AGInventors: Christoph Täschler, Gilbert Clausen
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Patent number: 8309736Abstract: The application relates to the use of a salt associating an ammonium cation with an alkyl H-phosphonate anion of the following formula (I) in which R is a hydrocarbon radical, the pointed bond can be present or not, the radical R3 being then present or absent, as an ionic liquid. The ammonium cation is preferably an imidazolium cation. This ionic liquid is particularly useful in the field of green chemistry as a substitute for organic solvents. The application also relates to a method for preparing such a salt by the direct dealkylation of the corresponding dialkylphosphite by the appropriate nitrated base, in one step and without any solvent. The application also relates to a method for preparing mixed methylated phosphites.Type: GrantFiled: February 15, 2008Date of Patent: November 13, 2012Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paul Sabatier Toulouse IIIInventors: Hoang-Phuong Nguyen, Michel Baboulene
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Publication number: 20120252052Abstract: A method of quantifying a target non-peptidic compound having an amino group contained in one or more biological samples, which comprises a step of producing a difference in the mass of the target non-peptidic compound between samples, by using a combination of two or more kinds of stable isotopes of a compound represented by the formula (I): wherein R1, R2 and R3 are the same or different and each is hydrogen, halogen or alkyl, or a salt thereof, as a labeling compound; and a kit and the like usable for such method.Type: ApplicationFiled: March 30, 2012Publication date: October 4, 2012Applicants: Taiyo Nippon Sanso Corporation, National University Corporation University of FukuiInventors: Shigeru MATSUKAWA, Kazumi NARITA, Haruki SHIMODAIRA
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Publication number: 20120177712Abstract: This invention relates to a bipolar antimicrobial particle for use in laundry detergent compositions, fabric conditioners, personal care and cosmetic compositions and a process for making the same. In view of the foregoing, it is an object of the present invention to provide a stabile antimicrobial agent immobilised on a carrier particle. It is a further objective to provide an antimicrobial particle with improved retention to the fabric so that larger amounts of antimicrobial will be available even after rinsing. Surprisingly it has been found that antimicrobial molecules tagged by surface reaction onto naturally occurring asymmetric clay surfaces, act as an antimicrobial particle with improved retention properties with improved stability.Type: ApplicationFiled: August 30, 2010Publication date: July 12, 2012Inventors: Arpita Bhattacharya, Sudipta Ghosh Dastidar, Vidula Iyer, Suresh Sambamurthy Jayaraman, Maya Treesa Saji
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Publication number: 20120178769Abstract: The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.Type: ApplicationFiled: July 15, 2010Publication date: July 12, 2012Applicant: The University of Medicine and DentistryInventor: Alexey G. Ryazanov
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Patent number: 8211896Abstract: Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.Type: GrantFiled: October 1, 2010Date of Patent: July 3, 2012Assignee: Chemocentryx, Inc.Inventors: Solomon Ungashe, Zheng Wei, J. J. Wright, Andrew Pennell
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Publication number: 20120157680Abstract: PROBLEM: Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point. MEANS FOR SOLVING THE PROBLEM: The present invention is the invention of the ionic liquid represented by the general formula [1]: {wherein, R1 to R3 and n pieces of R4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R5 to R7 each independently represent alkyl group, aralkyl group, or aryl group, R8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R1 to R7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R3 and R4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R5 to R7 or R5 to R6 may form hetero ring with nitrogen atom binding thereto}.Type: ApplicationFiled: August 30, 2010Publication date: June 21, 2012Applicant: Wako Pure Chemical Industries, Ltd.Inventors: Tsutomu Watahiki, Kuniaki Okamoto, Motoshige Sumino
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Patent number: 8168683Abstract: A fluorinated pyridinium cationic compound of formula (I) wherein, Rf is F(CF2)6(CH2CF2)m(CH2CH2)n—, m and n are each independently integers of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.Type: GrantFiled: October 15, 2009Date of Patent: May 1, 2012Assignee: E. I. du Pont de Nemours and CompanyInventors: Sheng Peng, Allison Mary Yake, Cheryl Lynn Casper
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Publication number: 20120101012Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.Type: ApplicationFiled: March 1, 2010Publication date: April 26, 2012Applicant: The Lubrizol CorporationInventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Gieselman, Christopher L. Friend, Patrick E. Mosier, Michelle M. Rogers, Mark T. Tierney
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Publication number: 20120077677Abstract: The invention relates to the use of 4-phenylbutyric acid and/or salts thereof, of the formula (I) for enhancing stress tolerance in plants to abiotic stress, preferably drought stress, and to the associated enhancement in plant growth and/or increase in plant yield.Type: ApplicationFiled: April 5, 2011Publication date: March 29, 2012Applicant: BAYER CROPSCIENCE AGInventors: Lothar Willms, Stefan Lehr, Marco Busch, Gunter Donn, Christopher Hugh Rosinger, Ines Heinemann, Isolde Haeuser-Hahn, Martin Jeffrey Hills
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Patent number: 8106217Abstract: The present invention relates to ionic liquids of low viscosity and high electrochemical stability, in particular for use in the area of electrochemistry and as solvents for carrying out chemical reactions.Type: GrantFiled: May 12, 2006Date of Patent: January 31, 2012Assignee: Merck Patent GmbHInventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Michael Heckmeier, German Bissky, Helge Willner
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Patent number: 8101749Abstract: The invention relates to a method for producing onium salts with tetrafluoroborate anion by reacting an onium halide with an oxonium tetrafluoroborate, sulfonium tetrafluoroborate, or triphenylcarbonium tetrafluoroborate.Type: GrantFiled: November 18, 2005Date of Patent: January 24, 2012Assignee: Merck Patent Gesellschaft mit beschrankter HaftungInventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Andriy Kucheryna, Helge Willner
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Patent number: 8093393Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.Type: GrantFiled: October 31, 2005Date of Patent: January 10, 2012Assignee: MUSC Foundation for Research DevelopmentInventors: Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen
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Publication number: 20110318691Abstract: An embodiment of the composition contains any of compounds of general formula (I) below:Type: ApplicationFiled: June 28, 2011Publication date: December 29, 2011Applicant: FUJIFILM CORPORATIONInventors: Tomotaka TSUCHIMURA, Hideaki TSUBAKI, Takeshi KAWABATA
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Publication number: 20110294153Abstract: Method and reagent for converting a carboxylic acid to a positively charged amide. The method and reagent facilitate positive ion mass spectral analysis of carboxylic acids.Type: ApplicationFiled: April 1, 2011Publication date: December 1, 2011Applicant: WASHINGTON, UNIVERSITY OFInventors: Michael H. Gelb, Frantisek Turecek, James Bollinger
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Patent number: 8022017Abstract: Corrosion of metallic tubulars in an oil, gas or geothermal well may be inhibited by introducing into the well a dithiazine of the formula: wherein R is selected from the group consisting of a C1 to C10 saturated or unsaturated hydrocarbyl group or a C1 to C10 ?-hydroxy saturated or unsaturated hydrocarbyl group. The dithiazine may be isolated from a whole spent fluid formed by reaction of hydrogen sulfide and a triazine. Alternately, the whole spent fluid containing the dithiazine may be introduced into the well. In addition, the dithiazine or whole spent fluid may be formulated with at least one component selected from alkyl, alkylaryl or arylamine quaternary salts; mono or polycyclic aromatic amine salts; imidazoline derivative or a quaternary salt thereof; a mono-, di- or trialkyl or alkylaryl phosphate ester; or a monomeric or oligomeric fatty acid.Type: GrantFiled: December 21, 2009Date of Patent: September 20, 2011Assignee: Baker Hughes IncorporatedInventor: Grahame Nigel Taylor
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Patent number: 8022018Abstract: Corrosion of metallic tubulars in an oil, gas or geothermal well may be inhibited by introducing into the well a dithiazine or dithiazine of the formula: wherein R is selected from the group consisting of a C1 to C12 saturated or unsaturated hydrocarbyl group or a C1 to C10 ?-hydroxy saturated or unsaturated hydrocarbyl group; R1 is selected from the group consisting of a C1-C24 straight chain or branched alkyl group or a C1-C24 arylalkyl; R2 is selected from the group consisting of X-R4-X, R4 being a C1-C6 alkyl group; and X is chlorine, bromine or iodine. The dithiazine may he isolated from a whole spent fluid formed by reaction of hydrogen sulfide and a triazine. Alternately, the whole spent fluid containing the dithiazine may be introduced into the well. The dithiazines of formulae (II) and (III) are quaternized derivatives of the dithiazine of formula (I).Type: GrantFiled: August 24, 2010Date of Patent: September 20, 2011Assignee: Baker Hughes IncorporatedInventor: Grahame Nigel Taylor