The Ring Nitrogen Of The Six-membered Hetero Ring Is Pentavalent (e.g., Quaternary Pyridinium Salts, Etc.) Patents (Class 546/347)
  • Patent number: 10450329
    Abstract: A process for preparing a difluoro chelato borate salt comprising an anion A of formula (I) wherein is a bidentate radical derived from a 1,2-, 1,3- or 1,4-diol, from a 1,2-, 1,3- or 1,4-dicarboxylic acid or from a 1,2-, 1,3- or 1,4-hydroxycarboxylic acid by abstracting the two H atoms of pairs of adjacent OH groups of the respective diol, hydroxycarboxylic acid or dicarboxylic acid. The process includes step (i) reacting (a) one or more BF3 sources; (b) a dihydric compound selected from 1,2-, 1,3- and 1,4-diols, 1,2-, 1,3- and 1,4-dicarboxylic acids, and 1,2-, 1,3- and 1,4-hydroxycarboxylic acids; (c) one or more second boron sources which do not contain F; and (d) one or more proton acceptors.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: October 22, 2019
    Assignee: Gotion Inc.
    Inventors: Nicole Holub, Juergen Herbel
  • Patent number: 10367227
    Abstract: An electrolyte composition and a metal-ion battery employing the same are provided. The electrolyte composition includes a metal chloride, a chlorine-containing ionic liquid, and an additive, wherein the additive has a structure represented by Formula (I) [M]i[(A(SO2CxF2x+1)y)b?]j??Formula (I), wherein M can be imidazolium cation, ammonium cation, azaannulenium cation, . . . etc., wherein M has a valence of a; a can be 1, 2, or 3; A can be N, O, Si, or C; x can be 1, 2, 3, 4, 5, or 6; y can be 1, 2, or 3; b can be 1, 2, or 3; i can be 1, 2, or 3; j can be 1, 2, or 3; a/b=j/i; and when y is 2 or 3, the (SO2CxF2x+1) moieties are the same or different.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: July 30, 2019
    Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
    Inventors: Che-Wei Chang, Wen-Sheng Chang, Chun-Tsung Hsu, Yu-Wen Yeh, Tai-Feng Hung, Chang-Chung Yang
  • Patent number: 10312551
    Abstract: The present invention relates to a preparation method of ionic liquids, particularly to a one-step reaction method used for synthesizing quaternary ammonium compounds or quaternary phosphonium compounds. In the method, a nitrogenous or phosphorous compound, a proton compound, and a carbonate ester are added into a reactor simultaneously to synthesize corresponding the quaternary ammonium ionic liquid or the quaternary phosphonium ionic liquid through said one-step reaction, i.e., ‘one-pot method’ reaction, during which three reactants are involved. The present invention also provides a lithium ion secondary battery comprising the ionic liquid prepared by above-mentioned preparation method. The ionic liquid preparation method of the present invention can widen the choice range of raw materials needed when preparing ionic liquids, and further widen the synthesized ionic liquid species.
    Type: Grant
    Filed: September 10, 2016
    Date of Patent: June 4, 2019
    Assignee: MICROVAST POWER SYSTEMS CO., LTD.
    Inventors: Zhuoqun Zheng, Dawei Shen, Jian Qiu, Yunhua Nie, Xiaozhen Zhao, Danyi Li
  • Patent number: 9944878
    Abstract: The present invention relates to a lubricant and/or clean-out composition comprising: (a) a dispersant component comprising a succinimide dispersant and/or a quaternary ammonium salt dispersant; (b) a carrier fluid component; and (c) an optional corrosion inhibitor, as well as methods of cleaning out deposits in a lubricant system, such as a hydraulic system, using such compositions.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: April 17, 2018
    Assignee: The Lubrizol Corporation
    Inventors: Betsy J. Butke, Grenville Holt
  • Patent number: 9822063
    Abstract: The present invention refers to new solid forms of Enclomiphene citrate and Enclomiphene base, processes for preparing thereof and uses.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: November 21, 2017
    Assignee: F.I.S.—FABBRICA ITALIANA SINTETICI S.P.A
    Inventors: Pierluigi Padovan, Lorenzo Caruana, Nicolas Tesson
  • Patent number: 9636298
    Abstract: The invention relates to prodrugs for use in the inhibition of histone deacetylase. The prodrugs of the present invention have good aqueous solubility and good aqueous stability. The prodrugs of the invention advantageously are metabolized to the active ingredient in plasma or in the blood stream of a warm-blooded animal. The invention also provides compositions and, and methods for making the prodrugs, and methods for using the prodrugs to treat fungal infections.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: May 2, 2017
    Inventors: Alain Ajamian, Yves Andre Chantigny, Arkadii Vaisburg, Franck Raeppel, Stephane Raeppel, Robert Deziel
  • Patent number: 9593170
    Abstract: A compound that increases the photocuring rate of a photocurable composition and reduces the force for releasing a cured product from a mold is provided. A compound is represented by general formula (1): where Rf represents an alkyl group at least part of which is substituted with fluorine, RO represents an oxyalkylene group or a repeated structure of an oxyalkylene group, N represents a nitrogen atom, RA represents an alkyl group, and RB represents an alkyl group or a hydrogen atom.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: March 14, 2017
    Assignee: Canon Kabushiki Kaisha
    Inventors: Toshiki Ito, Takeshi Honma, Shiori Yonezawa, Hitoshi Sato, Youji Kawasaki
  • Patent number: 9475997
    Abstract: Processes for removing sulfur and nitrogen contaminants from hydrocarbon streams are described. The processes include contacting the hydrocarbon stream comprising the contaminant with lean carbenium pseudo ionic liquid or a combination of carbenium pseudo ionic liquid and ionic liquid to produce a mixture comprising the hydrocarbon and rich carbenium pseudo ionic liquid or carbenium pseudo ionic liquid and ionic liquid comprising the contaminant. The mixture is separated to produce a hydrocarbon effluent and a rich carbenium pseudo ionic liquid or carbenium pseudo ionic liquid and ionic liquid effluent comprising the rich carbenium pseudo ionic liquid or carbenium pseudo ionic liquid and ionic liquid comprising the contaminant.
    Type: Grant
    Filed: November 24, 2014
    Date of Patent: October 25, 2016
    Assignee: UOP LLC
    Inventors: Erin M. Broderick, Alakananda Bhattacharyya, Shurong Yang, Beckay J. Mezza
  • Patent number: 9000180
    Abstract: In one form, processes for the production of certain N-substituted sulfoximine N-oxides are provided. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: April 7, 2015
    Assignee: Dow AgroSciences LLC
    Inventors: Douglas C. Bland, Ronald Ross, Jr., Peter L. Johnson, Timothy C. Johnson
  • Publication number: 20150090639
    Abstract: Ionic liquids of the general formula C+A? where C+ represents an organic cation, specifically, but not limited to the imidazolium, pyridinium, isoquinolinium, ammonium types, which have aliphatic and aromatic substituents, while A? represents a carboxylate, aromatic and aliphatic anion. The ionic liquids are synthesized under conventional heating or microwave irradiation This invention is also related to the application of ionic liquids to remove sulfur compounds of naphthas through a liquid-liquid extraction and the recovery and reuse of ionic liquids by the application of heat, reduced pressure and washing with solvents.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventors: Rafael Martinez Palou, Natalya Victorovna Likhanova, Eugenio Alejandro Flores Oropeza, Diego Javier Guzman Lucero
  • Patent number: 8946442
    Abstract: Foams of ionic compounds are described. Methods of making the foams are also provided. The foams are ionic and can be used for catalysis, separations, gas storage, biosensors, electronics, and electrochemical applications.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: February 3, 2015
    Assignee: E I du Pont de Nemours and Company
    Inventors: Mark Brandon Shiflett, Akimichi Yokozeki
  • Publication number: 20150027928
    Abstract: Methylcarbonate-based ionic liquids (LIs) or carboxylates, derived from aliphatic or aromatic carboxylic acids are provided for the extraction of nitrogen compounds from hydrocarbon mixture (HCs) by liquid-liquid selective extraction, at room temperature and atmospheric pressure, where the LIs are immiscible with the HCs. This process is performed through an extraction by stifling two phases, followed by separation, or in a continuous flow system where the nitrogenous compounds are transferred to the phase formed by the LI and the total nitrogen content is substantially reduced in the HCS phase. The ionic liquids have the general formula C+A?, where: C+ is a heterocyclic organic cation, or quaternary ammonium-based; and A? is a methylcarbonate- or carboxylates-based anion, derived from aliphatic or aromatic carboxylic acids.
    Type: Application
    Filed: July 23, 2014
    Publication date: January 29, 2015
    Inventors: Natalya Victorovna LIKHANOVA, Rodolfo Juventino MORA VALLEJO, Georgina Cecilia LAREDO SANCHEZ, Irina Victorovna LIJANOVA, Bernando RODRIGUEZ HEREDIA
  • Publication number: 20140377667
    Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.
    Type: Application
    Filed: July 25, 2012
    Publication date: December 25, 2014
    Applicants: JACOBS UNIVERSITY BREMEN gGMBH, WESTFALISCHE WILHELMS UNIVERSITAT MUNSTER
    Inventors: Gerd-Volker Roschenthaler, Martin Winter, Katja Vlasov, Nataliya Kalinovich, Christian Schreiner, Raphael Wilhelm Schmitz, Romek Ansgar Muller, Rene Schmitz, Alexandra Lex-Balducci, Miriam Kunze
  • Publication number: 20140371266
    Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and gastrointestinal tract disorders.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 18, 2014
    Inventors: Peter CROOKS, Linda P. DWOSKIN, Guangrong ZHENG, Sangeetha SUMITHRAN, Zhenfa ZHENG
  • Patent number: 8907109
    Abstract: Psoralen compounds of Formula (I): wherein (N+ Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: wherein R is C1-C30 hydrocarbyl, which may be linear, branched or cyclic and contains from 1 to 15 carbon-carbon double bonds, which may be conjugated or unconjugated with one another or may include an aryl ring, and may contain one or more substituents; R1 is hydrogen, aryl, heteroaryl, alkyl, cycloalkyl, heterocyclyl, alkenyl, alkynyl, alkene-aryl, alkene-heteroaryl, alkene-heterocyclyl, alkene-cycloalkyl, fused cycloalkylaryl, fused cycloalkylheteroaryl, fused heterocyclylaryl, fused heterocyclyheteroaryl, alkylene-fused cycloalkylaryl, alkylene-fused cycloalkylheteroaryl, alkylene-fused heterocyclylaryl, alkylene-fused heterocyclyheteroaryl; n is an integer from 1 to 8 and X is a pharmaceutically acceptable counter ion; and their use in methods for the treatment of a cell proliferat
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: December 9, 2014
    Assignees: Immunolight, LLC, Duke University
    Inventors: Eric Toone, David Gooden, Tuan Vo-Dinh, Frederic A. Bourke, Jr.
  • Publication number: 20140348753
    Abstract: The development of a series of fluorescent materials including heterocycle-functionalized luminogens with aggregation-induced/enhanced emission (AIE/AEE), long wavelength emission, and high solid state fluorescence quantum efficiency is contemplated. The described fluorescent materials are promising candidates in selective luminescence-based chemosensor for Hg2+ or ATP, fluorescent staining for mitochondria in living cells with high photostability, stimuli-responsive luminescent materials, and materials for optical waveguides. In addition, these heterocycle-functionalized luminogens are particularly useful as fluorescent labels for biopolymers such as peptides, antibodies, or nucleic acids, making them useful as AIE-active biocompatible probes for clinical cancer imaging and diagnostics.
    Type: Application
    Filed: May 24, 2013
    Publication date: November 27, 2014
    Inventors: Benzhong TANG, Wing Yip LAM, Na ZHAO, Min LI, Bin LIU, Haibin SHI, Dan DING
  • Patent number: 8846937
    Abstract: Provided are monoquaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a nicotinic acetylcholine receptor, and for the prevention and/or treatment of central nervous system disorders, substance use and/or abuse, and or gastrointestinal tract disorders.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: September 30, 2014
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter Crooks, Linda P. Dwoskin, Guangrong Zheng, Sangeetha Sumithran, Zhenfa Zheng
  • Patent number: 8841460
    Abstract: A compound, or a salt thereof, having the formula wherein Y is n is 1 or 2; each R is independently H, alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl; R1 is H, lower alkyl or aralkyl; R2 is selected from H, acyl, aralkyl, phosphonyl, —SO2R3; —C(O)R5; —C(O)OR7 or —C(O)NR9R10; R3; R5; R7; R9 and R10 independently are selected from H, lower alkyl, aralkyl or aryl; and R20 is selected from alkyl, substituted alkyl, a polyether moiety, carboxyl, substituted carboxyl, carbamate, substituted carbonate, carbonyloxy, alkoxy, substituted alkoxy, haloalkyl, halogen, nitro, amino, aryloxy, cyano, hydroxyl, or sulfonyl.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: September 23, 2014
    Assignee: State of Oregon Acting by and Through the State Board of Higher Education on Behalf of the University of Oregon
    Inventors: Darren W. Johnson, Calden Carroll, Michael M. Haley, Jeff Engle
  • Publication number: 20140262818
    Abstract: A process for preparing an aqueous solution of N-ethyl-2-methylpyridinium bromide (2-MEPy), comprising reacting 2-picoline and ethyl bromide in a pressure reactor at a temperature above the melting point of the reaction mixture, combining the reaction product with water, wherein said reaction product consists essentially of 2-MEPy in a liquid form, and recovering an aqueous solution of 2-MEPy.
    Type: Application
    Filed: March 20, 2014
    Publication date: September 18, 2014
    Applicant: BROMINE COMPOUNDS LTD.
    Inventors: Iris BEN-DAVID, Gershon MIASKOVSKI, Igor KOMPANIETS
  • Publication number: 20140249059
    Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.
    Type: Application
    Filed: May 14, 2014
    Publication date: September 4, 2014
    Inventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Giesleman, Christopher L. Friend, Patrick E. Mosier, Michele M. Rogers, Mark T. Tierney
  • Patent number: 8821716
    Abstract: The present invention relates to an improved desulfurization process using an ionic liquid compound of general formula C+A?, where C+ represents an organic cation such as alkyl-pyridinium, di-alkyl imidazolium and tri-alkyl imidazolium; and A? is an anion of halides of iron (III), such as, for example, FeCl4?. The desulfurization process is also improved when producing the ionic liquid compound by heating the reactants using microwave energy. The ionic liquids can be used to desulfurize hydrocarbon mixtures by a liquid-liquid extraction.
    Type: Grant
    Filed: May 26, 2009
    Date of Patent: September 2, 2014
    Assignee: Instituto Mexicano del Petroleo
    Inventors: Natalya Victorovna Likhanova, Rafael Martinez Palou, Jorge Froylan Palomeque Santiago
  • Publication number: 20140243247
    Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.
    Type: Application
    Filed: May 14, 2014
    Publication date: August 28, 2014
    Applicant: The Lubrizol Corporation
    Inventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Giesleman, Christopher L. Friend, Patrick E. Mosier, Michele M. Rogers, Mark T. Tierney
  • Patent number: 8796330
    Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds, prodrugs thereof, and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: August 5, 2014
    Assignee: Methylgene Inc.
    Inventors: Robert Déziel, Alain Ajamian
  • Patent number: 8785480
    Abstract: In one embodiment, processes for the preparation of certain functionalized pyridine N-oxides are provided. In one form, the functionalized pyridine N-oxides include 2-substituted-5-(1-alkylthio)alkyl-pyridine N-oxides. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: July 22, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Douglas C. Bland, Ronald Ross, Jr., Peter L. Johnson, Timothy C. Johnson
  • Patent number: 8754111
    Abstract: A method for the synthesis of N-substituted 3-acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine.
    Type: Grant
    Filed: July 18, 2013
    Date of Patent: June 17, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Peter Gebauer, Dieter Heindl, Carina Horn
  • Patent number: 8735585
    Abstract: Disclosed is a compound of formula (I) and salts thereof. Also disclosed are methods of making the compound of formula (I) and the use of the compound as an intermediate for making pharmaceutically active compounds such as 11-?-hydroxysteroid hydrogenase type 1 (11-?-HSD1) inhibitors.
    Type: Grant
    Filed: August 14, 2012
    Date of Patent: May 27, 2014
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Bo Qu, Anjan Saha, Jolaine Savoie, Xudong Wei, Nathan K. Yee
  • Patent number: 8728567
    Abstract: The present invention pertains to the double complex salts in optoelectronic components, like organic diodes, organic transistors or organic lasers, in particular an organic solar cell (OSC, OPP) and in particular from oligomers built from charged metal complexes.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: May 20, 2014
    Assignee: Cynora GmbH
    Inventors: Hartmut Yersin, Tobias Fischer, Uwe Monkowius
  • Patent number: 8669114
    Abstract: The subject of the invention at hand are novel, a little basic, fluorinated pentafluorophenyl imide anions, which can be used as anions in ionic liquids. Methods for producing ionic liquids are described, which contain these novel pentafluorophenyl imide ions as anions, as well as quaternary organic ammonium ions, guanidinium ions, N-organo-pyridinium ions, imidazolium, imidazolidinium or benzimidazolidinium ions, alkyl-alkylidene phosphoranes or aryl-alkylidene phosphoranes as cations. Alternative methods according to the present invention provide ionic liquids through reaction of ketene N,N-diacetals or alkyl or aryl-alkylidene phosphoranes with acids. The ionic liquids according to the present invention are suitable, for example, as solvents for syntheses, as mobile and/or stationary phase in chromatography, as electrolyte systems for batteries, galvanic elements, fuel cells and rechargeable battery packs.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: March 11, 2014
    Assignee: Philipps-Universitaet Marburg
    Inventors: Jorg Sundermeyer, Thomas Linder
  • Patent number: 8648202
    Abstract: The invention relates to bis(perfluoroalkyl)phosphinous acids, bis(perfluoroalkyl)thiophosphinous acids and derivatives, the synthesis thereof and the use thereof, in particular for the synthesis of air-stable metal complexes for catalytic processes.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: February 11, 2014
    Assignee: Merck Patent GmbH
    Inventors: Berthold Hoge, Anne Julia Bader, Boris Kurscheid, Nikolai (Mykola) Ignatyev, Emil Ferdinand Aust
  • Publication number: 20130288886
    Abstract: A method for preparing an ionic compound by mixing at least one compound of formula CxAy-zH2O (1) with at least one hydrogen donor and heating the mixture obtained is provided. The said ionic compound remains in a physical state selected from the group consisting of liquid and semisolid at a temperature below 150° C., preferably below 125° C.
    Type: Application
    Filed: June 22, 2011
    Publication date: October 31, 2013
    Applicant: RELIANCE INDUSTRIES LTD.
    Inventors: Pavan Kumar Aduri, Parasuveera Uppara, Uday Ratnaparkhi, Mangesh Sakhalkar
  • Publication number: 20130280555
    Abstract: A magnetic disk according to one embodiment of the present invention includes a base material and a lubricant layer provided on or over a base material. The lubricant layer contains a rod-like ionic liquid crystal compound having a cation group and an anion group.
    Type: Application
    Filed: April 18, 2013
    Publication date: October 24, 2013
    Applicants: Samsung Electro-Mechanics Japan Advanced Technology Co., Ltd., UNIVERSITY OF YAMANASHI
    Inventors: Yuichiro HARAMOTO, Mitsuo KODAMA
  • Publication number: 20130102506
    Abstract: A lubricating base oil includes at least one of ionic liquids containing a compound represented by a formula (1): Z+A?, in which Z+ represents a cation and A? represents an anion, in which Z+ is a cyclic quaternary ammonium ion having two different side chains and A? is a conjugated amide ion.
    Type: Application
    Filed: July 27, 2011
    Publication date: April 25, 2013
    Applicant: Idemitsu Kosan Co., Ltd.
    Inventors: Yukio Yoshida, Yukitoshi Fujinami
  • Publication number: 20120330023
    Abstract: Alkylpyridinium dicyanamide of the formula: in which Rn1 is cyano or C1-20-alkyl and n is an integer from 0 to 3 and any R1 radicals present are the same or different, and in which R2 is C1-20-alkyl. There are processes for their preparation from alkylpyridinium halides and alkali metal dicyanamide, They can be used as polar solvents.
    Type: Application
    Filed: April 6, 2005
    Publication date: December 27, 2012
    Applicant: LONZA AG
    Inventors: Christoph Täschler, Gilbert Clausen
  • Patent number: 8309736
    Abstract: The application relates to the use of a salt associating an ammonium cation with an alkyl H-phosphonate anion of the following formula (I) in which R is a hydrocarbon radical, the pointed bond can be present or not, the radical R3 being then present or absent, as an ionic liquid. The ammonium cation is preferably an imidazolium cation. This ionic liquid is particularly useful in the field of green chemistry as a substitute for organic solvents. The application also relates to a method for preparing such a salt by the direct dealkylation of the corresponding dialkylphosphite by the appropriate nitrated base, in one step and without any solvent. The application also relates to a method for preparing mixed methylated phosphites.
    Type: Grant
    Filed: February 15, 2008
    Date of Patent: November 13, 2012
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite Paul Sabatier Toulouse III
    Inventors: Hoang-Phuong Nguyen, Michel Baboulene
  • Publication number: 20120252052
    Abstract: A method of quantifying a target non-peptidic compound having an amino group contained in one or more biological samples, which comprises a step of producing a difference in the mass of the target non-peptidic compound between samples, by using a combination of two or more kinds of stable isotopes of a compound represented by the formula (I): wherein R1, R2 and R3 are the same or different and each is hydrogen, halogen or alkyl, or a salt thereof, as a labeling compound; and a kit and the like usable for such method.
    Type: Application
    Filed: March 30, 2012
    Publication date: October 4, 2012
    Applicants: Taiyo Nippon Sanso Corporation, National University Corporation University of Fukui
    Inventors: Shigeru MATSUKAWA, Kazumi NARITA, Haruki SHIMODAIRA
  • Publication number: 20120177712
    Abstract: This invention relates to a bipolar antimicrobial particle for use in laundry detergent compositions, fabric conditioners, personal care and cosmetic compositions and a process for making the same. In view of the foregoing, it is an object of the present invention to provide a stabile antimicrobial agent immobilised on a carrier particle. It is a further objective to provide an antimicrobial particle with improved retention to the fabric so that larger amounts of antimicrobial will be available even after rinsing. Surprisingly it has been found that antimicrobial molecules tagged by surface reaction onto naturally occurring asymmetric clay surfaces, act as an antimicrobial particle with improved retention properties with improved stability.
    Type: Application
    Filed: August 30, 2010
    Publication date: July 12, 2012
    Inventors: Arpita Bhattacharya, Sudipta Ghosh Dastidar, Vidula Iyer, Suresh Sambamurthy Jayaraman, Maya Treesa Saji
  • Publication number: 20120178769
    Abstract: The present invention discloses novel compounds for inhibiting eEF2 kinase and methods of use thereof.
    Type: Application
    Filed: July 15, 2010
    Publication date: July 12, 2012
    Applicant: The University of Medicine and Dentistry
    Inventor: Alexey G. Ryazanov
  • Patent number: 8211896
    Abstract: Compounds are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: July 3, 2012
    Assignee: Chemocentryx, Inc.
    Inventors: Solomon Ungashe, Zheng Wei, J. J. Wright, Andrew Pennell
  • Publication number: 20120157680
    Abstract: PROBLEM: Providing a novel ionic liquid, which is low-cost, environment-friendly, and has low viscosity and melting point. MEANS FOR SOLVING THE PROBLEM: The present invention is the invention of the ionic liquid represented by the general formula [1]: {wherein, R1 to R3 and n pieces of R4 each independently represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, R5 to R7 each independently represent alkyl group, aralkyl group, or aryl group, R8 represents alkyl group, aralkyl group, aryl group, or the one represented by the general formula [2]: (wherein T represents alkylene chain having 1 to 8 carbon atoms, n represents 1 or 2, and R1 to R7 are the same as the above-described), X represents nitrogen atom or phosphorus atom, n represents 1 or 2. When n is 1, R3 and R4 are bound and may form cyclohexene ring together with the adjacent carbon atoms. In addition, when X is nitrogen atom, R5 to R7 or R5 to R6 may form hetero ring with nitrogen atom binding thereto}.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 21, 2012
    Applicant: Wako Pure Chemical Industries, Ltd.
    Inventors: Tsutomu Watahiki, Kuniaki Okamoto, Motoshige Sumino
  • Patent number: 8168683
    Abstract: A fluorinated pyridinium cationic compound of formula (I) wherein, Rf is F(CF2)6(CH2CF2)m(CH2CH2)n—, m and n are each independently integers of 1 to 3, and R is H, C1 to C5 linear or branched alkyl, or C1 to C5 linear or branched alkoxy, having surfactant properties for lowering surface tension in an aqueous medium or solvent medium, and for use as a foaming agent.
    Type: Grant
    Filed: October 15, 2009
    Date of Patent: May 1, 2012
    Assignee: E. I. du Pont de Nemours and Company
    Inventors: Sheng Peng, Allison Mary Yake, Cheryl Lynn Casper
  • Publication number: 20120101012
    Abstract: A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen cation and an organic anion having at least one hydrocarbyl group of sufficient length to impart oil solubility to the detergent, the detergent having a total base number (TBN) to total acid number (TAN) ratio of at least 2:1 imparts ash-free basicity to a lubricant composition.
    Type: Application
    Filed: March 1, 2010
    Publication date: April 26, 2012
    Applicant: The Lubrizol Corporation
    Inventors: Ewan E. Delbridge, Virginia A. Carrick, John K. Pudelski, Matthew D. Gieselman, Christopher L. Friend, Patrick E. Mosier, Michelle M. Rogers, Mark T. Tierney
  • Publication number: 20120077677
    Abstract: The invention relates to the use of 4-phenylbutyric acid and/or salts thereof, of the formula (I) for enhancing stress tolerance in plants to abiotic stress, preferably drought stress, and to the associated enhancement in plant growth and/or increase in plant yield.
    Type: Application
    Filed: April 5, 2011
    Publication date: March 29, 2012
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Lothar Willms, Stefan Lehr, Marco Busch, Gunter Donn, Christopher Hugh Rosinger, Ines Heinemann, Isolde Haeuser-Hahn, Martin Jeffrey Hills
  • Patent number: 8106217
    Abstract: The present invention relates to ionic liquids of low viscosity and high electrochemical stability, in particular for use in the area of electrochemistry and as solvents for carrying out chemical reactions.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: January 31, 2012
    Assignee: Merck Patent GmbH
    Inventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Michael Heckmeier, German Bissky, Helge Willner
  • Patent number: 8101749
    Abstract: The invention relates to a method for producing onium salts with tetrafluoroborate anion by reacting an onium halide with an oxonium tetrafluoroborate, sulfonium tetrafluoroborate, or triphenylcarbonium tetrafluoroborate.
    Type: Grant
    Filed: November 18, 2005
    Date of Patent: January 24, 2012
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Nikolai (Mykola) Ignatyev, Urs Welz-Biermann, Andriy Kucheryna, Helge Willner
  • Patent number: 8093393
    Abstract: The present invention relates to cationic ceramides, their dihydro-analogs and aromatic analogs and their derivatives, comprising a pyridinium group. Also provided are methods for making cationic ceramides comprising a pyridinium group, and their use for treating or preventing diseases associated with cell overproliferation and sphingolipid signal transduction, such as cancer, inflammation, and stenosis. The compounds are also useful as mitochondritropic agents that are localized to mitochondria carrying with them chemical cargoes, such as drugs, or signaling molecules, such as fluorophores for probing organelle structure and functions.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: January 10, 2012
    Assignee: MUSC Foundation for Research Development
    Inventors: Alicja Bielawska, Zdzislaw M. Szulc, Yusuf A. Hannun, Lina M. Obeid, Besim Ogretmen
  • Publication number: 20110318691
    Abstract: An embodiment of the composition contains any of compounds of general formula (I) below:
    Type: Application
    Filed: June 28, 2011
    Publication date: December 29, 2011
    Applicant: FUJIFILM CORPORATION
    Inventors: Tomotaka TSUCHIMURA, Hideaki TSUBAKI, Takeshi KAWABATA
  • Publication number: 20110294153
    Abstract: Method and reagent for converting a carboxylic acid to a positively charged amide. The method and reagent facilitate positive ion mass spectral analysis of carboxylic acids.
    Type: Application
    Filed: April 1, 2011
    Publication date: December 1, 2011
    Applicant: WASHINGTON, UNIVERSITY OF
    Inventors: Michael H. Gelb, Frantisek Turecek, James Bollinger
  • Patent number: 8022017
    Abstract: Corrosion of metallic tubulars in an oil, gas or geothermal well may be inhibited by introducing into the well a dithiazine of the formula: wherein R is selected from the group consisting of a C1 to C10 saturated or unsaturated hydrocarbyl group or a C1 to C10 ?-hydroxy saturated or unsaturated hydrocarbyl group. The dithiazine may be isolated from a whole spent fluid formed by reaction of hydrogen sulfide and a triazine. Alternately, the whole spent fluid containing the dithiazine may be introduced into the well. In addition, the dithiazine or whole spent fluid may be formulated with at least one component selected from alkyl, alkylaryl or arylamine quaternary salts; mono or polycyclic aromatic amine salts; imidazoline derivative or a quaternary salt thereof; a mono-, di- or trialkyl or alkylaryl phosphate ester; or a monomeric or oligomeric fatty acid.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: September 20, 2011
    Assignee: Baker Hughes Incorporated
    Inventor: Grahame Nigel Taylor
  • Patent number: 8022018
    Abstract: Corrosion of metallic tubulars in an oil, gas or geothermal well may be inhibited by introducing into the well a dithiazine or dithiazine of the formula: wherein R is selected from the group consisting of a C1 to C12 saturated or unsaturated hydrocarbyl group or a C1 to C10 ?-hydroxy saturated or unsaturated hydrocarbyl group; R1 is selected from the group consisting of a C1-C24 straight chain or branched alkyl group or a C1-C24 arylalkyl; R2 is selected from the group consisting of X-R4-X, R4 being a C1-C6 alkyl group; and X is chlorine, bromine or iodine. The dithiazine may he isolated from a whole spent fluid formed by reaction of hydrogen sulfide and a triazine. Alternately, the whole spent fluid containing the dithiazine may be introduced into the well. The dithiazines of formulae (II) and (III) are quaternized derivatives of the dithiazine of formula (I).
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: September 20, 2011
    Assignee: Baker Hughes Incorporated
    Inventor: Grahame Nigel Taylor
  • Publication number: 20110207036
    Abstract: An electrophoretic particle salt that includes a cationic electrophoretic particle and an anionic group ionically associated with the cationic electrophoretic particle is employed in an electrophoretic display. A spacer group chemically bonds a cationic moiety to a surface of the electrophoretic particle. A method of making the electrophoretic particle salt includes particle surface modification, nucleophilic substitution to create an interim salt and anion exchange. The electrophoretic particle salt has an ionization constant that favors dissociation into a positively charged electrophoretic particle and the anionic group in a nonpolar medium. The electrophoretic display includes a pair of electrodes and a dispersion of the electrophoretic particle salt in a nonpolar medium in a gap between the pair of electrodes.
    Type: Application
    Filed: October 30, 2008
    Publication date: August 25, 2011
    Inventors: Yoocharn Jeon, Zhang-Lin Zhou