Abstract: A yellow light emitting device may have a light source and a color converter wherein at most 1% of the total emitted radiant power of the yellow light emitting device is emitted in a wavelength range shorter than 520 nm, as well as the use of the yellow light emitting device.

Abstract: Color converter comprising at least one polymer and at least one organic fluorescent dye comprising at least one structural unit of the formula (I) where the structural unit may be mono- or polysubstituted by identical or different substituents and where one or more CH groups of the six-membered ring of the benzimidazole structure shown may be replaced by nitrogen.

Abstract: The instant invention describes biisoquinoline compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.

Abstract: The present invention relates to cyanated naphthalenebenzimidazole compounds of the formula (I) and mixtures thereof, in which R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are each independently hydrogen, cyano or aryl which is unsubstituted or has one or more identical or different substituents RAr, where RAr is as defined in the claims and in the description, with the proviso that the compounds of the formula I comprise at least one cyano group. The invention further relates to color converters comprising at least one polymer as a matrix material and at least one cyanated naphthalenebenzimidazole compound or mixtures thereof as a fluorescent dye, to the use of the color converters and to lighting devices comprising at least one LED and at least one color converter.

Abstract: The present invention provides a new compound and an organic electronic device using the same. The organic electronic device according to the present invention exhibits excellent properties in views of efficiency, driving voltage and a life span.

Abstract: Disclosed embodiments concern polycyclic alkaloid compounds and methods for their use and synthesis. Particular embodiments concern polycyclic alkaloids having a fused, six-membered ring, while other embodiments concern polycyclic alkaloids having a fused, five-membered ring. Methods for making the polycyclic alkaloids are disclosed, as well as methods for their use as prophylactics or treatments for certain diseases. Also disclosed are pharmaceutical compositions comprising the polycyclic alkaloids and their use.

Abstract: The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.

Abstract: Color converter comprising at least one polymer and at least one organic fluorescent dye comprising at least one structural unit of the formula (I) where the structural unit may be mono- or polysubstituted by identical or different substituents and where one or more CH groups of the six-membered ring of the benzimidazole structure shown may be replaced by nitrogen.

Abstract: The present invention relates to compounds of the formulae Ia and Ib in which the variables R, n, A, B, R1 and R2 are each as defined in the description. The present invention further relates to the use of compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers in solar cells and photodetectors, and to solar cells and photodetectors which comprise such compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers.

Abstract: The present invention provides systems and methods for production of activatable diazo-derivatives for use in labeling nucleotides. Labeling nucleotides is accomplished by contacting a stable hydrazide derivative of a detectable moiety with an activating polymer reagent which is used to directly label the nucleotide sample. Labeling occurs on the phosphate backbone of the nucleotide which does not perturb hybridization of the labeled nucleotide with its anti-sense strand. Since the method involves direct labeling, all types of nucleotides can be labeled without prior amplification or alteration.

Abstract: The present invention provides compounds of Formula (I-IV): compositions containing the same, and methods of use thereof such as for the treatment of cancer.

Abstract: The present invention relates to compounds of the formulae Ia and Ib in which the variables R, n, A, B, R1 and R2 are each as defined in the description. The present invention further relates to the use of compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers in solar cells and photodetectors, and to solar cells and photodetectors which comprise such compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers.

Abstract: The present invention provides a novel nitrogen-containing heterocyclic derivative and an organic electronic device using the same. The organic electronic device according to the present invention has excellent properties in terms of efficiency, driving voltage, and a life span.

Abstract: The present invention provides a novel nitrogen-containing heterocyclic derivative and an organic electronic device using the same. The organic electronic device according to the present invention has excellent properties in terms of efficiency, driving voltage, and a life span.

Abstract: The present invention relates to the treatment of protozoal diseases by administering cytotoxic and/or cytostatic compounds, in particular those used in anticancer therapy, to patients. In particular, the invention relates to the use of anticancer agents that can penetrate into the CNS for treatment of late stage African sleeping sickness or cerebral malaria.

Abstract: Compounds of structural Formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination

Abstract: The present invention relates to a process for the preparation of pure irinotecan or salts thereof, and a process for the preparation of intermediate compound 7-ethyl-10-hydroxycamptothecin.

Abstract: Fluorescent monomers are described and claimed which are synthesized by reacting a substituted or non-substituted naphthalic anhydride with an amine and with a moiety containing a polymerizable group. Such monomers are useful for the preparation of tagged treatment polymers. Such tagged treatment polymers are useful as scale inhibitors in industrial water systems.

Abstract: Compositions for treating cancer comprising an amount of a camptothecin with a 7-ring &bgr;-hydroxy lactone ring of the formula 1

Abstract: The present invention provides novel conjugates of camptothecin compounds and long-chain unsaturated fatty acid. The novel conjugates can be used to treat mammalian cell proliferative diseases such as cancer.

Abstract: A polymorphic form of 9-nitrocamptothecin is provided, the polymorph being characterizable as having, by differential scanning calorimetry, an endotherm at between 273.9 to 275.9° C., and an exotherm at between 279.3 and 281.3° C.

Abstract: A polymorphic form of 9-nitrocamptothecin is provided, the polymorph being characterizable as having, by differential scanning calorimetry, no observable endotherm and an exotherm at between 273.6 and 275.6° C., and a solution NMR spectrum with multiplets at 1.7 and 3.7 ppm shifts.

Abstract: Disclosed are novel aromatic compounds of the formula(I) wherein G, E, W, Ar, X, Y and Z. The compounds are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.

Abstract: Novel granulatimide compounds and pharmaceutical formulations thereof are provided.

Abstract: The invention pertains to a method for preparing derivatives of the pyrazolinylnaphthalic acid having the general formula where Ar1 and Ar2 are unsubstituted or substituted phenyl radicals bearing in the para position an alkylated or acylated oxy- or amino group, or a polynuclear aryl radical, and Ar3 is a substituted N-naphthalimid or 1,8-naphthylene-1′,2′-benzimidazole. Compounds of the above general formula are high-efficient red organic luminophors and are used widely as luminescent components of dyes for plastics and liquid scintillators, in hydrogeology to study water streams, to label the chemical industry wastewaters, as laser dyes, etc.

Abstract: The invention concerns novel halogenated derivatives of the vinblastine and vinorelbine family, corresponding to general formula (I) and their therapeutically acceptable salts. The invention also concerns the application of these compounds in therapy and their method of preparation. The invention further concerns a novel method for preparing vinflunine or 20',20'-difluoro-3',4'-dihydrovinorelbine, of formula (a).

Abstract: Benzopyran dyes of the formula ##STR1## where n is 1 or 2,Xhu 1 is oxygen or imino,X.sup.2 is cyano or carbamoyl,R.sup.1 and R.sup.2 are independently of each other C.sub.1 -C.sub.13 -alkyl subject to the proviso that the sum total of the carbon atoms present in R.sup.1 and R.sup.2 shall be at least 10, andR.sup.3 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogen, cyano, nitro, carbamoyl, mono- or di(C.sub.1 -C.sub.4 -alkyl)carbamoyl, sulfamoyl or mono- or di(C.sub.1 -C.sub.4 -alkyl)sulfamoyl,are obtainable from novel iminocoumarin intermediates and useful for dyeing or printing synthetic materials.

Abstract: A compound and all possible racemic or optically active isomer forms, selected from the group consisting of compound of the formula ##STR1## wherein the substituents are defined as set forth in the application as filed. Useful for treating cerebral insufficiencies of anoxic or ischemic origin.

Abstract: Dyes of the formula ##STR1## in which F is the radical of an indigoid dye, of a benzothioxanthene or of an aromatic dye which contains at least 4 alicyclic and/or heterocyclic, fused six-membered rings and at least two ring keto groups and is not water-soluble, R.sub.1 is a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted cycloalkyl radical, a substituted or unsubstituted aryl radical or a radical of the formula--A--Qwhere A is a substituted or unsubstituted C.sub.1-4 -alkylene radical and Q is a basic radical, which may be quaternised, and R.sub.2 is hydrogen or a substituted or unsubstituted C.sub.1-4 -alkyl radical, or in which R.sub.1 and R.sub.2 together with the ##STR2## group are a phthalimide radical, and R.sub.3 is hydrogen, a substituted or unsubstituted C.sub.1-4 -alkyl radical, a substituted or unsubstituted aryl radical, a C.sub.1-4 -alkoxycarbonyl radical or a N,N-di-C.sub.1-4 -alkylcarboxamide radical and n is 1, 2, 3 or 4.

Abstract: This invention provides for a process of preparing certain trifluoromethyl substituted 7H-benzimidazo[2,1-a]benz[de]isoquinoline-7-ones.

Abstract: Dyestuffs of the formulaD--N.dbd.N--A Iin whichD represents the radical of a diazo component andA represents the radical of a coupling component of the formulae ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 designate hydrogen or non-ionic radicals,R designates hydrogen or an optionally substituted alkyl, cycloalkyl, aryl, aralkyl or heterocyclic radical,X designates OH or ##STR2## T designates the remaining members of a fused-on ring and Y and Z designate hydrogen, optionally substituted alkyl or optionally substituted aryl,processes for their preparation and process for pigmenting organic material using the dyestuffs of the formula I.

Abstract: 1,1'-Binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid compounds having the following formula: ##STR1## wherein R.sub.1 is hydrogen, halogen, or alkyl; when X is oxygen, Y is hydrogen, alkyl, a cycloalkyl, or an aryl containing at least one substituent from the group including: halogen, alkyl, or alkoxy, when X is nitrogen, Y is ##STR2## wherein R.sub.2 is hydrogen, halogen, or alkyl; Y being linked to X with the formation of a benzimidazole cycle.The method for preparing the compounds according to the present invention resides in the treatment of that 1,1'-binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid anhydride with an alkali to give a corresponding salt which is condensed with orthophenylenediamines upon heating at reflux at a pH of from 6.3 to 6.8. The resulting benzimidazole-1,1'-binaphthyl-4,4',5,5',8,8'-hexacarboxylic acid anhydride having the formula: ##STR3## wherein R.sub.

Abstract: Benzimidazo-[1,2-a]-quinolines of the formula ##STR1## In the solid and dissolved state, the compounds of the invention are strongly fluorescing from reddish-blue to red, depending on the substitution. The compounds can be used as optical brighteners and as fluorescent dyestuffs. Furthermore they are valuable intermediates for the preparation of optical brighteners and fluorescing dyestuffs. They are distinguished by a very good fastness to light.

Abstract: Dyestuffs of the formula (I) ##STR1## wherein F represents a ring system with at least 3 rings which are angularly condensed with one another, n is 1, 2 or 3, and R, R.sub.1 and R.sub.2 represent optionally substituted alkyl groups which can be interrupted by heteroatoms and also represent cycloalkyl, aralkyl, aryl or heterocyclic radicals, R and R.sub.1 can also represent hydrogen atoms, R.sub.1 and R.sub.2, together with the nitrogen atom, are able to form a ring with 5 or 6 members, and R and R.sub.2 can combine to form a nitrogen-containing heterocycle.

Abstract: Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts having the formula I: ##STR1## wherein R.sub.1 is hydrogen, lower alkyl, C.sub.4 -C.sub.6 cycloalkyl, di(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, 4-morpholinyl or 2,2-dimethylhydrazino;R.sub.2 is hydrogen, lower alkyl, lower alkylamino, di(lower alkyl)amino, C.sub.4 -C.sub.6 cycloalkylamino, lower alkoxy(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidinyl, methyl-1-pyrrolidinyl, methyl-1-piperidinyl, hexahydro-1H-azepin-1-yl, 4-morpholinyl, benzylamino, N-methylbenzylamino or 2-phenylethylamino;R.sub.3 is hydrogen or methyl;X is an anion;with the proviso that at least one of R.sub.1 and R.sub.2 is other than hydrogen, lower alkyl or C.sub.4 -C.sub.6 cycloalkyl; and with the further proviso that when R.sub.2 is dimethylamino, at least one of R.sub.1 and R.sub.3 is other than hydrogen, and intermediates used in the preparation thereof are disclosed.

Abstract: Novel anthanthrene derivatives characterized by the general formula ##STR1## where Alk is an alkyl C.sub.1 -C.sub.10, X.sub.1, X.sub.2 and X.sub.3, X.sub.4 stand for a group (1) --CH.sub.2 --CH.sub.2 -- or a group ##STR2## wherein Y is an oxygen atom or an imino-group, either unsubstitutedor containing substituents: alkyl, cycloalkyl, aryl; or, else, one of X.sub.1 and X.sub.2, as well as one of X.sub.3 and X.sub.4 is a CO-group, the other X then entering, corresponding, into the benzimidazole cycle. The structure of said compounds can be either symmetrical or non-symmetrical with respect to X.sub.1, X.sub.2 and X.sub.3, X.sub.4.Said anthanthrene derivatives are produced by cyclization in the presence of condensing agents of compounds having the formula ##STR3## where Z is either CHOH or CO, and Alk, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are as defined above.Some of the said anthanthrene derivatives are used as dyes or pigments, while others serve as starting products for producing dyes or pigments.

Abstract: Benzimidazo-[1,2-a]-quinolines, of the general formula ##STR1## which may be substituted, are prepared by reacting 2-alkoxy-benzaldehydes with 2-phenylsulfonylmethylene-benzimidazoles. The compounds are strongly fluorescing and can be used as optical brighteners and fluorescent dyestuffs.