Plural Chalcogens Bonded Directly To The Same Cyclo As Is The -(c=x)- Group Patents (Class 546/54)
Trialkoxybenzoyl bonded directly to at least one of the chalcogens (e.g., reserpine, etc.) (Class 546/55)
  • Combination therapy for the treatment of cancer and immunosuppression
    Patent number: 9511064
    Abstract: The invention relates to novel Rauwolfia alkaloid derivatives of formula (I) combinations of Rauwolfia alkaloid derivatives and a mitochondrial inhibitor, e.g. metformin, and the use of Rauwolfia alkaloid derivatives in combination with mitochondrial inhibitor for the treatment of cancer and for achieving clinical immunosuppression. The invention also relates to a fluorescence-based method for predicting the sensitivity of a cancer cell towards a compound of formula (I).
    Type: Grant
    Filed: July 3, 2013
    Date of Patent: December 6, 2016
    Assignee: BASILEA PHARMACEUTICA AG
    Inventors: Jens Pohlmann, Don Gary Benjamin, Christoph Moroni
  • CHEMOTHERAPEUTIC FOR INDUCING AN MSH2 DEPENDENT APOPTOTIC PATHWAY
    Publication number: 20140323511
    Abstract: Active compounds include compounds of Formula I and Formula II are described: along with compositions containing the same and methods of use thereof.
    Type: Application
    Filed: February 28, 2014
    Publication date: October 30, 2014
    Applicant: Wake Forest University Health Sciences
    Inventors: Freddie R. Salsbury, JR., Karin D. Scarpinato, S. Bruce King
  • METHODS TO INHIBIT OR AUGMENT AN INFLAMMATORY RESPONSE
    Publication number: 20120065401
    Abstract: Isolated and purified chemokine peptides, variants, and derivatives thereof, as well as chemokine peptide analogs, are provided.
    Type: Application
    Filed: June 7, 2011
    Publication date: March 15, 2012
    Applicant: Cambridge Enterprise Limited
    Inventors: David J. Grainger, Lauren Marie Tatalick
  • Hydroisoquinoline derivatives
    Patent number: 5441956
    Type: Grant
    Filed: January 5, 1994
    Date of Patent: August 15, 1995
    Assignee: Smithkline Beecham Farmaceutici S.p.A.
    Inventors: Vittorio Vecchietti, Giulio Dondio, Silvano Ronzoni, Roberto Colle
  • Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
    Patent number: 5416089
    Abstract: Anticancer compounds of formula I: ##STR1## and pharmaceutically acceptable salts thereof, wherein: R.sup.1, R.sup.2 and R.sup.3 are independently selected H, CH.sub.3, NH.sub.2, NO.sub.2, and CN;R.sup.9 and R.sup.10 are H or alkyl or halo, X.sup.1 and Y.sup.1 or X.sup.2 and Y.sup.2, when present, join together to form, independently, a six membered 1N heterocycle substituted with 1-2 R.sup.3 ; or the group: ##STR2## wherein one of W or Z is C.dbd.O and the other is C.dbd.O, NH, S or O; or when X.sup.2 and Y.sup.2 are not joined together and when R.sup.2 is in the 4-position, then X.sup.2 and R.sup.2 may join together to form an ethylene bridge; are disclosed.
    Type: Grant
    Filed: June 24, 1993
    Date of Patent: May 16, 1995
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: Arthur D. Patten, Gregory Pacofsky, Steven P. Seitz, Emeka A. Akamike, Robert J. Cherney, Robert F. Kaltenbach, III, Michael J. Orwat