Nitrogen, Other Than As Nitro Or Nitroso, Attached Directly Or Indirectly To The Tricyclo Ring System By Nonionic Bonding Patents (Class 546/99)
  • Patent number: 8921558
    Abstract: Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: December 30, 2014
    Assignee: BASF SE
    Inventors: Thomas Gessner, Helmut Reichelt, Ingo Münster, Martin Könemann, Neil Gregory Pschirer, Jianqiang Qu, Rüdiger Sens, Anja Schwögler, Antonio Manetto
  • Publication number: 20140336178
    Abstract: The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
    Type: Application
    Filed: April 29, 2014
    Publication date: November 13, 2014
    Applicants: The General Hospital Corporation, Massachusetts Institute of Technology
    Inventors: Aleksey G. Kazantsev, Anne B. Young, David E. Housman, Steven M. Hersch
  • Publication number: 20140256767
    Abstract: A method of identifying compounds as direct inhibitors of Keap1-Nrf2 interaction through high-throughput screening and lead development. The direct inhibitors of Keap1-Nrf2 interaction are more specific and free of various undesirable effects than existing indirect inhibitors, and are potential drug candidates of chemopreventive and therapeutic agents for treatment of various diseases or conditions involving oxidative stress and/or inflammation, including but not limited to cancers, diabetes, Alzheimer's, and Parkinson's. Novel compounds are identified and methods of preventing or treating diseases or conditions related to Keap1-Nrf2 interaction activity by use of the novel compounds identified or compositions containing such compounds are also disclosed.
    Type: Application
    Filed: October 31, 2012
    Publication date: September 11, 2014
    Applicants: THE BROAD INSTITUTE, INC., RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
    Inventors: Longqin Hu, Sadagopan Magesh, Lin Chen, Timothy Lewis, Ben Munoz, Lili Wang
  • Publication number: 20140206714
    Abstract: Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives. Further disclosed is a pharmacophore of LPA2 receptor.
    Type: Application
    Filed: March 21, 2014
    Publication date: July 24, 2014
    Applicant: University of Tennessee Research Foundation
    Inventors: Renukadevi Patil, James Fells, Duane Miller, Gabor Tigyi
  • Publication number: 20140184997
    Abstract: Disclosed is a polyimide prepolymer, an alignment film and a method for preparing the same, as well as a liquid display device. The polyimide prepolymer has a repeating unit as shown in Formula (1) and is capped with a capping agent having a phenylethynyl group: wherein Ar is selected from one of the structures of the following Formulae (2) and (3): and n is an integer of between 3 and 8.
    Type: Application
    Filed: September 19, 2012
    Publication date: July 3, 2014
    Inventors: Wei Yan, Dan Wang
  • Publication number: 20140094610
    Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 3, 2014
    Inventors: Wenjie LI, Philomen DECROOS, Keith R. FANDRICK, Joe Ju GAO, Nizar HADDAD, Zhi-Hui LU, Bo QU, Sonia RODRIGUEZ, Chris H. SENANAYAKE, Yongda ZHANG, Wenjun TANG
  • Publication number: 20140080220
    Abstract: Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 20, 2014
    Applicant: BASF SE
    Inventors: Thomas Gessner, Helmut Reichelt, Ingo Münster, Martin Könemann, Neil Gregory Pschirer, Jianqiang Qu, Rüdiger Sens, Anja Schwögler, Antonio Manetto
  • Publication number: 20140073059
    Abstract: Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 13, 2014
    Applicant: BASF SE
    Inventors: Thomas Gessner, Helmut Reichelt, Ingo Münster, Martin Könemann, Neil Gregory Pschirer, Jianqiang Qu, Rüdiger Sens, Anja Schwögler, Antonio Manetto
  • Publication number: 20140073794
    Abstract: The present invention relates to high transmission yellow dye for LCD, dye dispersion comprising the dye, coloring composite comprising the dye dispersion, color filter comprising the coloring composite, and synthetic method thereof.
    Type: Application
    Filed: December 31, 2012
    Publication date: March 13, 2014
    Applicants: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, LG DISPLAY CO., LTD.
    Inventors: YoungHoon KIM, JiChul LIM, ByungGun AHN, SangHun HAN, JaePil KIM, SeHun KIM, Jun CHOI, JinWoong NAMGOONG
  • Publication number: 20140057936
    Abstract: Disclosed are compounds effective for inhibiting cellular apoptosis and for protecting cells and tissues from the apoptotic effects of chemotherapeutic agents and/or ionizing radiation. Compounds of the invention act as agonists of the LPA2 receptor. Compounds of the invention comprise non-lipid benzoic acid derivatives.
    Type: Application
    Filed: August 27, 2013
    Publication date: February 27, 2014
    Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
    Inventors: Renukadevi Patil, James Fells, Duane D. Miller, Gabor Tigyi
  • Patent number: 8609846
    Abstract: The present invention relates to compounds of the formulae Ia and Ib in which the variables R, n, A, B, R1 and R2 are each as defined in the description. The present invention further relates to the use of compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers in solar cells and photodetectors, and to solar cells and photodetectors which comprise such compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers.
    Type: Grant
    Filed: December 20, 2011
    Date of Patent: December 17, 2013
    Assignee: BASF SE
    Inventors: Neil Gregory Pschirer, Jan Schoeneboom, Felix Eickemeyer, Helmut Reichelt, Ruediger Sens, Ingmar Bruder
  • Publication number: 20130203733
    Abstract: The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
    Type: Application
    Filed: December 20, 2012
    Publication date: August 8, 2013
    Applicants: Massachusetts Institute of Technology, The General Hospital Corporation
    Inventors: The General Hospital Corporation, Massachusetts Institute of Technology
  • Patent number: 8420665
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: April 16, 2013
    Assignee: Northwestern University
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschl
  • Publication number: 20130079521
    Abstract: Provided are novel salts of 2-(1-azabicyclo-[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one, methods of using such salts, and processes for producing such salts.
    Type: Application
    Filed: November 14, 2012
    Publication date: March 28, 2013
    Applicant: CHEMAGIS LTD.
    Inventor: CHEMAGIS LTD.
  • Patent number: 8304544
    Abstract: The present invention provides novel palonosetron free base in an amorphous form and crystalline form-G and processes for their preparation. The present invention also provides a process for the preparation of palonosetron hydrochloride from the novel palonosetron free base in an amorphous form and/or in crystalline form-G.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: November 6, 2012
    Assignee: Glenmark Generics Limited
    Inventors: Mubeen Khan, Mahendra Patil Raghunath, Prashant Yadav Kundlik
  • Publication number: 20120267533
    Abstract: The present invention relates to processes for the preparation of Form I and Form II of palonosetron hydrochloride. The present invention further relates to a method of determining the polymorphic forms of palonosetron hydrochloride using Fourier-Transform Infra-red (FTIR) method.
    Type: Application
    Filed: June 30, 2010
    Publication date: October 25, 2012
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Gyanendra Pandey, Kaptan Singh, Surender Dhingra, Mohan Prasad, Tippasandra G. Chandrashekhar, Somenath Ganguly, Rita Santhakumar
  • Publication number: 20120253046
    Abstract: Provided are metabolites of palonosetron that can be used in treating animals, particularly humans, of the formula (I): or a pharmaceutically acceptable salt or prodrug thereof; wherein R1 and R4 independently can be H, hydroxyl, or carbonyl; and wherein R3 can be Formule (II) or Formule (III).
    Type: Application
    Filed: November 1, 2010
    Publication date: October 4, 2012
    Applicant: Helsinn Healthcare S.A.
    Inventor: Waldo Mossi
  • Publication number: 20120171129
    Abstract: Disclosure is provided for benzimidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions including these compounds, devices including these compounds, and methods of using the same.
    Type: Application
    Filed: June 10, 2010
    Publication date: July 5, 2012
    Inventors: Christian Melander, Steven A. Rogers, Robert W. Huigens, III
  • Patent number: 8211613
    Abstract: The present invention provides a radical generator having a naphthalimide structure or a crosslinking agent and a photosensitive compound having a function as a radical generator. A photoradical polymerization initiator of the present invention comprises a compound (a) having only one naphthalimide structure-containing group in one molecule. The radial generator of the present invention comprises a compound (c) having two or more naphthalimide structure-containing groups in one molecule and also functions as a crosslinking agent. A first photosensitive compound of the present invention comprises a compound (d) having a naphthalimide structure-containing group and an ethylenic unsaturated group in one molecule. A second photosensitive compound of the present invention comprises a polymer (e) of one or more radical polymerizable compounds containing the compound (d).
    Type: Grant
    Filed: July 2, 2008
    Date of Patent: July 3, 2012
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventor: Katsuya Sakayori
  • Publication number: 20120165530
    Abstract: The present invention relates to compounds of the formulae Ia and Ib in which the variables R, n, A, B, R1 and R2 are each as defined in the description. The present invention further relates to the use of compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers in solar cells and photodetectors, and to solar cells and photodetectors which comprise such compounds of the formula Ia or Ib or mixtures of compounds of the formulae Ia and Ib and/or isomers or mixtures of the isomers of the compounds of the formulae Ia and Ib as photosensitizers.
    Type: Application
    Filed: December 20, 2011
    Publication date: June 28, 2012
    Applicant: BASF SE
    Inventors: Neil Gregory PSCHIRER, Jan Schöneboom, Felix Eickemeyer, Helmut Reichelt, Rüdiger Sens, Ingmar Bruder
  • Patent number: 8188279
    Abstract: Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
    Type: Grant
    Filed: June 1, 2011
    Date of Patent: May 29, 2012
    Assignee: Allergan, Inc.
    Inventors: Santosh C. Sinha, Smita Bhat, Ken Chow, Richard L. Beard, John E. Donello, Michael Garst
  • Publication number: 20120122915
    Abstract: The present invention provides crystalline forms of Palonosetron hydrochloride, processes for their preparation and pharmaceutical compositions containing such crystalline forms of Palonosetron HCl.
    Type: Application
    Filed: December 23, 2011
    Publication date: May 17, 2012
    Inventors: Pierluigi ROSSETTO, Peter Lindsay MacDonald, Gaia Banfi, Csilla Nemethne Racz
  • Publication number: 20120097884
    Abstract: Material for thermal insulation including an aerogel obtained by drying an organogel prepared from the pseudopeptides of formula (I). in which R represents a side chain of an amino acid, R1 represents a (C1-C8)alkyl, (C1-C8)alkoxy, aryl, aryloxy, or glycoside group, n=1 or 2 and A represents an aromatic group with one or more rings.
    Type: Application
    Filed: May 18, 2010
    Publication date: April 26, 2012
    Applicant: INSTITUT NATIONAL POLYTECHNIQUE DE LORRAINE
    Inventors: Brigitte Jamart-Gregoire, Nicolas Brosse, Quoc Nghi Pham, Danielle Barth, Alexandre Scondo, Alain Degiovanni
  • Patent number: 8093391
    Abstract: This invention relates to an improved and scalable process for the preparation of substantially pure palonosetron and its acid addition salts, in particular hydrochloride (I) which comprises of, (a) converting intermediate (IIa) as such or as its freebase (II) to a crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) via hydrogenation under pressure with an appropriately chosen hydrogenation catalyst in an suitable organic solvent. (b) making the resulting crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) substantially free from (II) or (IIa) via halogenation reaction.
    Type: Grant
    Filed: January 5, 2010
    Date of Patent: January 10, 2012
    Assignee: Sterling Biotech Research Center
    Inventors: Sugata Chatterjee, Ajay Singh Rawat, Anil V. Pawar, Jetti Rajanikanth, Penigandla Venkateswarlu
  • Publication number: 20110300072
    Abstract: Use of benzimidazole-derived compounds of formula (I) according to the following structure, wherein x is a heteroatom selected from N, S, O, P, SO, SO2 and SO3, preferably from N, S and SO3 and most preferably from N and SO3; n may be 0 or 1, R1 is a group selected from formula (II) and formula (III) and R2 is a group selected from H and formula (IV) since the aforesaid serves for the production of a formulation used as a specific marker in the case of neurodegenerative diseases and tau pathologies.
    Type: Application
    Filed: July 22, 2009
    Publication date: December 8, 2011
    Applicant: SERVICIOS CIENTIFICOS NEUROINNOVATION LTDA.
    Inventors: Ricardo Maccioni Baraona, Leonel Rojo, Rodrigo Kuljis Azocar
  • Publication number: 20110295010
    Abstract: Aromatic non-polymeric amic acid salts are designed to be thermally converted into corresponding arylene diimides. These aromatic, non-polymeric amic acid salts can be used to prepare semiconducting thin films that can be used in various articles including thin-film transistor devices that can be incorporated into a variety of electronic devices. In this manner, the arylene diimide need not be coated but is generated in situ from a solvent-soluble, easily coated aromatic, non-polymeric amic acid salt at relatively lower temperature because the cation portion of the amic acid salt acts as an internal catalyst.
    Type: Application
    Filed: May 27, 2010
    Publication date: December 1, 2011
    Inventors: Deepak Shukla, Dianne M. Meyer, Wendy G. Ahearn
  • Publication number: 20110269966
    Abstract: An amic acid or amic ester precursor can be applied to a substrate and thermally converted into a thin organic semiconducting layer of the corresponding arylene diimide. This semiconducting layer can be used in various semiconductive articles such as organic light emitting diode (OLED), photodetector, sensor, logic circuit, memory element, capacitor, photovoltaic (PV) cell, or electronic devices. In this manner, the arylene diimide need not be coated but is generated in situ from a solvent-soluble and easily coated precursor compound.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 3, 2011
    Inventors: Deepak Shukla, Dianne M. Meyer, Wendy G. Ahearn
  • Publication number: 20110213150
    Abstract: Processes for the preparation of palonosetron hydrochloride and its crystalline forms.
    Type: Application
    Filed: May 9, 2011
    Publication date: September 1, 2011
    Applicants: DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.
    Inventors: Srinivas Katkam, Rajeshwar Reddy Sagyam, Vishnuvardhan Sunkara, Sridhar Munagala, Murali Mohan Muttavarapu
  • Publication number: 20110165691
    Abstract: Novel mono-azide substituted rylene-imide derivatives, their use in methods for the detection of analytes and reagents kits for the detection of analytes comprising said novel mono-azide substituted rylene-imide derivatives.
    Type: Application
    Filed: January 14, 2011
    Publication date: July 7, 2011
    Applicant: BASF SE
    Inventors: Thomas Geßner, Helmut Reichelt, Ingo Münster, Martin Könemann, Neil Gregory Pschirer, Jian Qiang Qu, Rüdiger Sens, Anja Schwögler, Antonio Manetto
  • Patent number: 7947506
    Abstract: A hydroxyquinolone compound formulated as a fluorescent dye for protein detection, assay, quantitation, etc. The hydroxyquinolone compound may be modified, for example, by adding or removing sulfate groups, changing hydrocarbon chain lengths, etc. to result in more desirable properties such as enhanced binding to basic proteins, enhanced solubility, etc. The dye has enhanced sensitivity over commercially available protein stains, and may be used to stain proteins in solution, proteins separated on gels, proteins transferred to solid supports, etc. Methods of using the dyes are also disclosed.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: May 24, 2011
    Assignee: Pierce Biotechnology, Inc.
    Inventors: Brian David Wolf, Surbhi Desai, Peter T. Czerney, Frank G. Lehmann, Bernd G. Schweder, Matthias S. Wenzel
  • Publication number: 20110021778
    Abstract: This invention relates to an improved and scalable process for the preparation of substantially pure palonosetron and its acid addition salts, in particular hydrochloride (I) which comprises of, (a) converting intermediate (IIa) as such or as its freebase (II) to a crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) via hydrogenation under pressure with an appropriately chosen hydrogenation catalyst in an suitable organic solvent. (b) making the resulting crude mixture of diastereomeric palonosetrons (VIII) or (VIIIa) contaminated with varying amounts of unconverted intermediate (II) or (IIa) substantially free from (II) or (IIa) via halogenation reaction.
    Type: Application
    Filed: January 5, 2010
    Publication date: January 27, 2011
    Inventors: Sugata Chatterjee, Ajay Singh Rawat, Anil V. Pawar, Jetti Rajanikanth, P. Venkateswarlu
  • Patent number: 7863048
    Abstract: Protein dyes whose molecular structure is that of a coumarin moiety coupled to a quaternary ammonium heterocycle through a vinyl or polyvinyl linkage demonstrate the ability to associate with proteins in a non-covalent, non-specific manner at low pH, where the associated form displays a significantly higher fluorescence emission than the unassociated form. This makes the dyes useful as selective labels for proteins at the low pH and eliminates the need for the removal of extraneous components from the medium in which the proteins reside prior to detection.
    Type: Grant
    Filed: October 19, 2009
    Date of Patent: January 4, 2011
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Thomas R. Berkelman
  • Publication number: 20100303719
    Abstract: The present invention relates to anti-cancer compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides analogs of the known anti-cancer compound amonafide, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with hyperproliferation.
    Type: Application
    Filed: January 12, 2009
    Publication date: December 2, 2010
    Applicant: NORTHWESTERN UNIVERSITY
    Inventors: Sui Huang, John Norton, Daniel Appella, Mark Witschi
  • Publication number: 20100292267
    Abstract: The present invention provides novel palonosetron free base in an amorphous form and crystalline form-G and processes for their preparation. The present invention also provides a process for the preparation of palonosetron hydrochloride from the novel palonosetron free base in an amorphous form and/or in crystalline form-G.
    Type: Application
    Filed: December 11, 2008
    Publication date: November 18, 2010
    Applicant: GLENMARK GENERICS LTD
    Inventors: Mubeen Khan, Mahendra Patil Raghunath, Prashant Yadav Kundlik
  • Publication number: 20100168093
    Abstract: The present invention relates to substituted pyrrolidine compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animal.
    Type: Application
    Filed: April 30, 2007
    Publication date: July 1, 2010
    Inventors: Miguel Angel Pericas-Brondo, Antoni Torrens-Jover, Susana Yenes-Minguez, Félix Cuevas Cordobés, Carmen Garcia Granda
  • Patent number: 7723399
    Abstract: The invention relates to novel N-substituted imides and polymerizable compositions comprising these N-substituted imides. The invention further relates to the use of N-substituted imides as polymerization initiators.
    Type: Grant
    Filed: October 31, 2005
    Date of Patent: May 25, 2010
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Peter Nesvadba, Johannes Benkhoff, Lucienne Bugnon, Karin Powell, Tunja Jung
  • Patent number: 7662862
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: February 16, 2010
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Susana Yenes Mínguez, Josep Mas Prió, Luz Romero Alonso, Alberto Dordal Zueras, Helmut Henrich Buschmann
  • Patent number: 7598359
    Abstract: A bis(indolestyryl) compound. The bis(indolestyryl) compound has formula (I): wherein A and B comprise benzene, naphthalene, or heterocyclic ring containing O, S, or N, R1 and R1? are H, halogen, C1-5 alkyl, nitro, ester, carboxyl, sulfo, sulfonamide, amide, sulfo ester, C1-3 alkoxy, amino, alkylamino, cyano, C1-6 alkylsulfonyl, or C2-7 alkoxy carbonyl, R2, R2?, R3, and R3? comprise H, C1-6 alkyl, C6-18 aryl, C2-6 alkenyl, C3-6 cycloalkenyl, or C3-6 cycloalkyl, R4 is H, C1-5 alkyl, hydroxyl, halogen, or alkoxy, R5 and R5? comprise H, halogen, C1-5 alkyl, nitro, C1-3 alkoxy, amino, cyano, C1-6 alkylsulfonyl, or C2-7 alkoxy carbonyl, W comprises oxygen, sulfur, selenium, —NR, or —C(CH3)2, n is 1˜18 and Z1 and Z2 are different and comprise an anion or an anionic organometallic complex with +1 or +2 valence, wherein R bonded to nitrogen is C1-4 alkyl.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: October 6, 2009
    Assignee: Industrial Technology Research Institute
    Inventors: Shin-Shin Wang, Jong-Lieh Yang, Chii-Chang Lai, Hui-Ping Tsai, Wen-Ping Chu, Chien-Wen Chen, Chien-Liang Huang, Wen-Yih Liao, Ming-Chia Lee
  • Publication number: 20090181971
    Abstract: The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.
    Type: Application
    Filed: August 13, 2007
    Publication date: July 16, 2009
    Inventors: Daniel Delorme, Soon Hyung Woo, Arkadii Vaisburg
  • Patent number: 7553336
    Abstract: The present invention has for an object brightening cationic naphthalene dyes of formula (I) and colorants for keratin fibers, particularly human hair, containing these compounds
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: June 30, 2009
    Assignee: Wella AG
    Inventors: Markus Speckbacher, Hans-Juergen Braun
  • Patent number: 7553965
    Abstract: The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some 2,2a,4,5-tetrahydro-1H-3-aza-acenaphthylen substituted sulfonamide compounds, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: June 30, 2009
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Antoni Torrens Jover, Susana Yenes Mínguez, Josep Mas Prió, Luz Romero Alonso, Alberto Dordal Zueras, Helmut Henrich Buschmann
  • Patent number: 7544215
    Abstract: The present invention has for an object novel naphthalene dyes of formula (I) and colorants for keratin fibers, particularly human hair, containing these compounds.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: June 9, 2009
    Assignee: Wella AG
    Inventors: Markus Speckbacher, Hans-Juergen Braun, Jessica Chassot
  • Publication number: 20090124807
    Abstract: The present invention relates to intermediates useful in the synthesis of Dolasetron and synthetic precursors thereof, as well as to processes for obtaining them. In addition, it refers to the hydrochloric salt of Dolasetron and polymorphic forms of Dolasetron and precursors thereof.
    Type: Application
    Filed: January 22, 2008
    Publication date: May 14, 2009
    Inventors: Juan Antonio Perez Andres, Pere Dalmases Barjoan, Joan Huguet Clotet
  • Publication number: 20090062329
    Abstract: The bisnaphthalimidopropyl derivatives with anti-parasitic and anti-cancer activity. Bisnaphthalimidopropyl derivatives (A) BNIPPut, BNIPDapen, BNIPDhex, BNIPDahep, BNIPDaoct, BNIPDanon, BNTPDadec, BNIPDadod, BNPDpta, BNIPDeta were synthesized in yields ranging from 50-70 and their cytotoxicity against colon cancer cells (CaCo-2) and the parasite Leishmania infantum determined using the MTT assay and by luciferase activity present in parasite, respectively. Cytotoxicity within CaCo-2 cells was manifested with IC50 values between 0.3 and 22 m M after 48 h of compounds incubation. Against Leishmania infantum, IC50 values were encompassed within a narrower concentration range of 0.39-2.09 m M, for pro-mastigote form, and between 5.24 and 17.42 m M, for axenic amastigote and between 2.43 and 9.52 m M, for intracellular amastigote forms.
    Type: Application
    Filed: June 15, 2007
    Publication date: March 5, 2009
    Inventors: Anabela Cordeiro Da Silva, Joana Alexandra Pinto Da Costa Tavares, Paul Kong Thoo Lin
  • Publication number: 20080206885
    Abstract: The present invention provides novel fluorophore compounds.
    Type: Application
    Filed: February 26, 2007
    Publication date: August 28, 2008
    Inventors: Barbara Imperiali, Galen S. Loving
  • Publication number: 20080132600
    Abstract: The invention relates to novel N-substituted imides and polymerizable compositions comprising these N-substituted imides. The invention further relates to the use of N-substituted imides as polymerization initiators.
    Type: Application
    Filed: October 31, 2005
    Publication date: June 5, 2008
    Inventors: Peter Nesvadba, Johannes Benkhoff, Lucienne Bugnon, Karin Powell, Tunja Jung
  • Patent number: 7364804
    Abstract: A light-emitting compound that has excellent carrier transportation properties and that can exhibit long wavelength light is disclosed. Further, a method for manufacturing the light-emitting compound in a high yield is disclosed. The disclosed light-emitting compound is a pyran derivative as represented by general formula 1: wherein A1 and A2 are individually a ?-conjugated system group having 6 to 16 conjugating carbon atoms; X1 is a dialkylamino group; and Y1 is a diarylamino group or an alkylarylamino group.
    Type: Grant
    Filed: August 13, 2004
    Date of Patent: April 29, 2008
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Sachiko Yamagata, Ryoji Nomura, Satoshi Seo
  • Publication number: 20080058367
    Abstract: The present application relates to a process for purification of palonosetron or its salt substantially free of its R-isomer and structure related impurities.
    Type: Application
    Filed: August 28, 2007
    Publication date: March 6, 2008
    Inventors: Raghavendracharyulu Venkata Palle, Madhavrao Marathe Anant, Nageshwar Gunda
  • Patent number: 7320849
    Abstract: Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula where Y1 and Y2 are, each independently, an arylamine group; R1 and R2 comprise, each independently, H, an alkyl group, an alkenyl group, a heterocyclic group, or an aromatic group; X1 and X2, each independently, are bridging groups; E1 and E2 are, each independently, an epoxy group; and Z is a linking group comprising an alkyl group, an alkenyl group, a heterocyclic group, or an aromatic group; and (b) a charge generating compound. The charge transport materials can be crosslinked to a polymeric bind, either directly or through a crosslinking agent. Corresponding electrophotographic apparatuses and imaging methods are described.
    Type: Grant
    Filed: December 31, 2003
    Date of Patent: January 22, 2008
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Nusrallah Jubran, Zbigniew Tokarski, Vytautas Getautis, Tadas Malinauskas, Vygintas Jankauskas, Valentas Gaidelis
  • Patent number: 7300732
    Abstract: Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formula, where R comprises a hydrogen, an alkyl group, an alkenyl group, a heterocyclic group, or an aromatic group; X comprises an arylamine group; and Y comprises a 9-fluorenylidene group having at least a solubilizing substituent; and (b) a charge generating compound. Corresponding electrophotographic apparatuses and imaging methods are described.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: November 27, 2007
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Nusrallah Jubran, Zbigniew Tokarski, Kam W. Law