Boron Or Silicon Containing Patents (Class 548/110)
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Patent number: 6617339Abstract: Compounds of formula (I) as defined herein, or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof, are useful as antibacterial agents. Processes for their manufacture and pharmaceutical compositions containing them are described.Type: GrantFiled: December 5, 2000Date of Patent: September 9, 2003Assignee: Syngenta LimitedInventor: Michael Barry Gravestock
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Patent number: 6610856Abstract: The present invention relates to a photo-stabilizer of the general formula (I): wherein R1 is hydrogen, halogen, C1 to C12 alkyl, alkoxy (linear and branched), R2 is hydrogen, C1-C8 alkyl, cyclopentyl, cyclohexyl or cumyl, R3 is hydrogen, C1-C4 alkyl, R4 is methyl or ethyl, R5 is C1-C8 alkyl, alkyl phenyl, alkoxy, acyl, cycloalkyl and allyl, X is O, NH, C1-C8 alkyloxy and alkylamino (linear or branched), to derivatives and intermediates thereof.Type: GrantFiled: July 25, 2002Date of Patent: August 26, 2003Assignee: Council of Scientific and Industrial ResearchInventors: Shroj Al Mohitkumar Desai, Raj Pal Singh
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Publication number: 20030158351Abstract: Phenylethynyl containing imide-silanes were prepared from aminoalkyl and aminoaryl alkoxy silanes and 4-phenyletbynylphthalic anhydride in toluene to form the imide in one step or in N-methyl-2-pyrrolidinone (NMP) to form the amide acid intermediate. Controlled molecular weight pendent phenylethynyl amide acid oligomers terminated with aminoaryl alkoxy silanes were prepared in NMP from aromatic dianhydrides, aromatic diamines, diamines containing pendent phenylethynyl groups and aminoaryl alkoxy silanes. The phenylethynyl containing imide-silanes and controlled molecular weight pendent phenylethynyl amide acid oligomers terminated with aminoaryl alkoxy silanes were used to improve the adhesion between phenylethynyl containing imide adhesives and inorganic substrates (i.e. metal). Hydrolysis of the alkoxy silane moiety formed a silanol functionality which reacted with the metal surface to form a metal-oxygen-silicon (oxane) bond under the appropriate reaction conditions.Type: ApplicationFiled: June 12, 2002Publication date: August 21, 2003Inventors: Joseph G. Smith, John W. Connell, Paul M. Hergenrother, Sharon E. Lowther, Cheol Park
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Publication number: 20030144251Abstract: The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis) 1Type: ApplicationFiled: July 18, 2002Publication date: July 31, 2003Applicant: Rhone-Poulenc Inc.Inventors: Tai-Teh Wu, Alain Chene, David Treadway Manning, Peter Wyatt Newsome, Nicholas Charles Ray, Jennifer Lantz Phillips, Patrick Doyle Lowder
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Publication number: 20030144437Abstract: The invention provides a method for converting a less active or slower to initiate system to a higher activity system so that at the end of a polymerization the most active species is present in the system. The invention generally relates to a process for converting a less active or slower to initiate catalyst system to a higher activity catalyst system wherein the process comprises contacting a protected N-heterocyclic carbene with a metathesis catalyst and an olefin in the presence of energy. One of the benefits of the invention is that the amount of catalyst required is less than or lowered in the presence of the protected N-heterocyclic carbene as compared to the amount of catalyst required in the absence of the protected N-heterocyclic carbene. The protected N-heterocyclic carbene can be unsaturated or saturated. In addition, the invention describes novel ruthenium initiators and methods of making the same.Type: ApplicationFiled: March 25, 2002Publication date: July 31, 2003Inventors: Andrew Bell, Robert H. Grubbs, John P. Morgan, Jason L. Moore
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Publication number: 20030130524Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzo ring, for example a trifluoromethyl group, which involves diazotizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: ApplicationFiled: December 10, 2002Publication date: July 10, 2003Inventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Publication number: 20030130232Abstract: Compounds of the formula 1Type: ApplicationFiled: September 23, 2002Publication date: July 10, 2003Applicant: Boehringer Ingelheim KGInventors: Ralf Anderskewitz, Kurt Schromm, Ernst-Otto Renth, Frank Himmelsbach, Franz Birke, Armin Fugner
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Publication number: 20030120083Abstract: Provided is a process for preparing 2H-benzotriazole UV absorbers containing a perfluoroalkyl moiety at the 5-position of the benzo ring, for example a trifluoromethyl group, which involves diazotizing the perfluoroalkyl substituted o-nitroaniline using concentrated sulfuric acid plus sodium nitrite or nitrosylsulfuric acid to form the corresponding monoazobenzene intermediate via the diazonium salt intermediate which is reduced to the corresponding 5-perfluoroalkyl substituted 2H-benzotriazole UV absorber compound by conventional reduction means. Also provided is a novel one-pot, multiphase reaction for the preparation of 2(2-nitrophenylazo) substituted phenols, which are precursors for 2H-benzotriazole UV absorbers.Type: ApplicationFiled: December 10, 2002Publication date: June 26, 2003Inventors: Mervin G. Wood, Deborah DeHessa, Joseph Suhadolnik, Andrew B. Naughton, Jerome Sanders, Jacqueline Lau, Rong Xiong, Joseph Babiarz
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Publication number: 20030100768Abstract: The present invention relates generally to a novel class of imidazolidinones of Formula (I): 1Type: ApplicationFiled: December 12, 2001Publication date: May 29, 2003Inventors: Amy Qi Han, Peter W. Glunz
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Publication number: 20030092913Abstract: The present invention relates to a photo-stabilizer of the general formula (I): 1Type: ApplicationFiled: July 25, 2002Publication date: May 15, 2003Inventors: Shroj Almohitkumar Desai, Raj Pal Singh
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Publication number: 20030088108Abstract: The present invention provides a novel imidazole/organic monocarboxylic acid salt derivative reaction product capable of improving the adhesion between a resin and a metal such as copper, steel or aluminum, or an inorganic material such as glass fiber, silica, aluminum oxide or aluminum hydroxide, a method for producing this imidazole/organic monocarboxylic acid salt derivative reaction product, and a surface treatment agent, resin additive and resin composition that use this imidazole/organic monocarboxylic acid salt derivative reaction product.Type: ApplicationFiled: September 5, 2001Publication date: May 8, 2003Inventors: Masashi Kumagai, Katsuyuki Tsuchida
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Patent number: 6559269Abstract: A curable resin composition which has excellent curability and storage stability, and in particular, which has improved storage stability under the condition where the resin composition only contains the resin component and the latent curing agent. A curable resin composition having a resin component having oxirane ring and thiirane ring at a ratio (oxirane ring/thiirane ring) of 95/5 to 1/100; and an oxazolidine compound represented by the following formula (1): wherein R1 represents a hydrocarbon group having 1 to 6 carbon atoms, and R2 and R3 independently represent hydrogen atom or a monovalent hydrocarbon group having 1 to 15 carbon atoms, or together form an alicyclic ring or an aromatic ring.Type: GrantFiled: March 7, 2002Date of Patent: May 6, 2003Assignee: The Yokohama Rubber Co., Ltd.Inventors: Hiroyuki Okuhira, Kazuo Suga
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Patent number: 6559310Abstract: The invention provides a process for covalently coupling organic compounds which comprises reacting an aromatic ring compound having a halogen or halogen-like substituent at a coupling position with a diboron derivative in the presence of a Group VIII metal catalyst and a suitable base. The invention also provides useful arylboron intermediates.Type: GrantFiled: May 21, 2002Date of Patent: May 6, 2003Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Sebastian Mario Marcuccio, Mary Rodopoulos, Helmut Weigold
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Publication number: 20030083445Abstract: The invention provides a method for converting a less active or slower to initiate system to a higher activity system so that at the end of a polymerization the most active species is present in the system. The invention generally relates to a process for converting a less active or slower to initiate catalyst system to a higher activity catalyst system wherein the process comprises contacting a protected N-heterocyclic carbene with a metathesis catalyst and an olefin in the presence of energy. One of the benefits of the invention is that the amount of catalyst required is less than or lowered in the presence of the protected N-heterocyclic carbene as compared to the amount of catalyst required in the absence of the protected N-heterocyclic carbene. The protected N-heterocyclic carbene can be unsaturated or saturated. In addition, the invention describes novel ruthenium initiators and methods of making the same.Type: ApplicationFiled: May 3, 2002Publication date: May 1, 2003Inventors: Robert H. Grubbs, Jason L. Moore, John P. Morgan, Andrew Bell
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Publication number: 20030069426Abstract: A salt-like chemical compound of the formula (I),Type: ApplicationFiled: September 13, 2002Publication date: April 10, 2003Inventors: Jorg Schottek, Gerhard Erker, Gerald Kehr
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Publication number: 20030055286Abstract: 1 This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).Type: ApplicationFiled: September 5, 2002Publication date: March 20, 2003Inventors: Katherine Louisa Widdowson, Qi Jin
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Patent number: 6534506Abstract: The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.Type: GrantFiled: April 6, 2001Date of Patent: March 18, 2003Assignee: Merck & Co., Inc.Inventors: Diem N. Nguyen, Craig A. Stump, Theresa M. Williams
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Patent number: 6534658Abstract: Oxadiazole derivatives represented by formula (I): (wherein R1 represents a hydrogen atom or an amino-protective group; R2, R3, and R4 each independently represents an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, or a 3,4-methylenedioxyphenyl group, or R3 and R4 are taken together to represent a C2-6 alkylene group), a process of producing the same, and a process for producing oxadiazole derivatives represented by formula (II): (wherein all symbols have the same meanings as described above) using the above derivative. According to the invention, the compound represented by formula (II) is produced through fewer steps in a high yield.Type: GrantFiled: December 19, 2001Date of Patent: March 18, 2003Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Tsutomu Kojima, Katsutoshi Hachiya, Kazuyuki Ohmoto
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Patent number: 6525099Abstract: The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.Type: GrantFiled: January 23, 2001Date of Patent: February 25, 2003Assignee: Eli Lilly and CompanyInventors: Macklin Brian Arnold, Winton Dennis Jones, Paul Leslie Ornstein, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
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Patent number: 6518266Abstract: The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R1 represents R5O, R5SO2, R5SO or R5S in which R5 is as defined herein; X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substituted C6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond; R2 is hydrogen, amino, chloro, bromo, iodo, cyano, C1-6 alkoxy, C1-6 alkyl or C6-10 aryl; and R3-R7 each represent hydrogen, halogen, straight- or branched-chain C1-4 alkyl or C1-4 alkoxy, either of which is unsubstituted or substituted by one or more halogen atoms, straight- or branched-chain C1-4 alkylthio or C1-4 alkylsulphinyl, either of which is substituted by one or more halogen atoms, nitro, cyano, or straight- or branched-chain C1-4 alkylsulphonyl group which is unsubstituted or substituted by one or more halogen atoms.Type: GrantFiled: July 21, 2000Date of Patent: February 11, 2003Assignees: 3-Dimensional Pharmaceuticals, Heska CorporationInventors: Daljit S. Dhanoa, Dario Doller, Sanath Meegalla, Richard M. Soll, Nancy Wisnewski, Gary Silver, Dan T. Stinchcomb, R. Lee Seward, Dimitris Agrafiotis, Deyou Sha
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Patent number: 6518257Abstract: To provide a composition having a steroid C17,20-lyase inhibitory activity and useful as an agent for the prophylaxis or treatment of prostatism and tumors such as breast cancer. A compound represented by the formula: wherein R is a hydrogen atom or a protecting group, R1 is a lower alkyl group or a cyclic hydrocarbon group, R2 is an aromatic hydrocarbon group optionally having substituents or an aromatic heterocyclic group optionally having substituents, R3 is a hydrocarbon group optionally having substituents, a hydroxyl group optionally having substituents, a thiol group optionally having substituents, an amino group optionally having substituents, an acyl group or a halogen atom, and n is an integer of 0 to 4, and a salt thereof have a steroid C17,20-lyase inhibitory activity, and are useful as an agent for the pophylaxis or treatment of prostatism and tumors such as beast cancer and the like.Type: GrantFiled: April 18, 2002Date of Patent: February 11, 2003Assignee: Takeda Chemical Industries, Ltd.Inventors: Akihiro Tasaka, Tomohiro Kaku, Masami Kusaka
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Publication number: 20030018198Abstract: Provided are a borosuccinimide compound obtained through reaction of (a) a succinic acid/anhydride substituted with an alkyl or alkenyl group having a number-average molecular weight of from 200 to 5,000, (b) a polyalkylene-polyamine of which at least 5 mol % has a terminal cyclic structure, and (c) a boron compound; and a succinimide compound obtained through reaction of (A) a succinic acid/anhydride substituted with an alkyl or alkenyl group having a molecular weight of from 200 to 5,000, with (D) a hydrocarbon-substituted polyalkylene-polyamine. These compounds are stable even at high temperatures and have good high-temperature detergency, and they are useful for ashless detergent dispersants having the ability to disperse fine particles. Also provided are a mixture of any of these compounds and a specific ester derivative; a lubricant additive and a fuel oil additive comprising the mixture as the essential ingredient; and a lubricant and a fuel oil composition containing the additive.Type: ApplicationFiled: May 22, 2002Publication date: January 23, 2003Inventors: Hiroaki Koshima, Ikumi Terada
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Patent number: 6509472Abstract: Prochiral ketones are enantioselectively reduced to chiral secondary alcohols with a compound having the formula I: where, the two R2 groups are identical and are each a substituted or unsubstituted, aryl, alkyl, cycloalkyl or aralkyl group; and R3 is a hydrogen atom or a substituted or unsubstituted, alkyl, aryl, aralkyl or alkoxy group; wherein the substituents on the R2 and R3 groups are substantially non-reactive.Type: GrantFiled: August 30, 2001Date of Patent: January 21, 2003Assignee: Schering CorporationInventor: Richard W. Draper
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Patent number: 6500957Abstract: A platinum complex is described to include a platinum(IV) metal center so positioned and oriented in the complex so as to complex in cis orientations with two hydride groups and with an alkyl group.Type: GrantFiled: May 16, 2002Date of Patent: December 31, 2002Assignee: Technion Research and Development Foundation Ltd.Inventors: Ehud Keinan, Ariel Haskel
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Patent number: 6489081Abstract: Compounds of formula I wherein R1, R2, and R3 independently of one another are hydrogen; C1-C20alkyl which is unsubstituted or substituted by OH, C1-C4alkoxy, C1-C4alkylthio, phenylthio, F, Cl, Br, I, CN, (C1-8alkyl)O—(CO)—, (C1-C4alkyl)—(CO)O— or/and di(C1-C4alkyl)amino; or R1, R2, and R3 independently of one another are C3-C6alkenyl; phenyl which is unsubstituted or substituted by OH, C1-C4alkoxy, C1-C4alkylthio, phenylthio, F, Cl, Br, I, CN, (C1-C8alkyl)O(CO)—, (C1-C4alkyl)—(CO)O— or/— and di(C1-C4alkyl)amino; or R1 and R2 together are C2-C9alkylene, o-xylylene, 2-butenylene, C3-C9oxaalkylene or C3-C9azaalkylene; R4, R5, R6, and R7 independently of one another are sec-C3-C20alkyl, tert-C4-C20alkyl or phenyl wherein these radicals are unsubstituted or substituted by OH, C1-C4alkoxy, C1-C4alkylthio, phenylthio, F, Cl, Br, I, CN, (C1-C8alkyl)O(CO)—, (C1-C4alkyl)—(CO)O— or/and di(C1-C4alkyl)amino; or R4 and R5, and/or R6 and R7Type: GrantFiled: November 30, 2000Date of Patent: December 3, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Akira Matsumoto, Yoshihiko Ito
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Publication number: 20020173488Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.Type: ApplicationFiled: March 18, 2002Publication date: November 21, 2002Applicant: Millennium Pharmaceuticals, Inc.Inventors: Julian Adams, Yu-Ting Ma, Ross Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
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Patent number: 6472414Abstract: Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) —O—; or (3) B is: and wherein L2, L1, R1, R2, R3, R3′, R3a, R3b, R4, R4′, R5, X, are as defined herein.Type: GrantFiled: May 18, 1999Date of Patent: October 29, 2002Assignee: Bristol-Myers Squibb CompanyInventors: Scott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, William A. Slusarchyk, Richard B. Sulsky, Joseph A. Tino
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Publication number: 20020132849Abstract: The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.Type: ApplicationFiled: September 15, 2001Publication date: September 19, 2002Inventors: Donald W. Hansen, Ronald Keith Webber, Barnett S. Pitzele, James Sikorski, Mark A. Massa, Timothy J. Hagen, Margaret Grapperhaus, Lijuan Jane Wang, Arija A. Bergmanis, Steven W. Kramer, E. Ann Hallinan
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Patent number: 6452032Abstract: Silicone-containing organic compounds useful as modulators of mammalian nuclear hormone receptors, particularly the retinoid receptors and the farnesoid receptors.Type: GrantFiled: June 9, 2000Date of Patent: September 17, 2002Assignee: Allergan Sales, LLCInventors: Richard L. Beard, Michael E. Garst, Roshantha A. Chandraratna
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Publication number: 20020128232Abstract: The present invention relates to novel angiogenic-inhibitory compounds of formula (I) 1Type: ApplicationFiled: October 12, 2001Publication date: September 12, 2002Inventors: Scott A. Henderson, Barry R. Matthews
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Patent number: 6448201Abstract: Benzoylcyclohexanediones and benzoylpyrazoles, their preparation and their use as herbicides and plant growth regulators. There are described benzoyl compounds of the formula (I), their preparation and their use as herbicides and plant growth regulators. In this formula (I), R1, R2, R3 and R4 are various radicals, X is an alkylene chain which may contain a hetero atom and Het is a heterocycle or heteroaromatic ring.Type: GrantFiled: November 2, 2000Date of Patent: September 10, 2002Assignee: Aventis CropScience GmbHInventors: Thomas Seitz, Lothar Willms, Thomas Auler, Hermann Bieringer, Felix Thürwächter
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Publication number: 20020115640Abstract: Substituted imidazoles and thiazoles having the formula 1Type: ApplicationFiled: July 25, 2001Publication date: August 22, 2002Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney,, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
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Patent number: 6436981Abstract: Compounds of formula 1 wherein: Y signifies halogen, C1-C4-alkoxy, C1-C4-alkylthio or hydroxy; R1 signifies methyl, ethyl or cyclopropyl; R2 signifies C1-C6-alkyl or C1-C6-alkyl substituted by 1 to 5 fluorine atoms; R3 is C1-C6-alkyl, C1-C6-alkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkoxy, C2-C6-alkenyl, C2-C6-alkenyloxy, C2-C6-alkinyl, C2-C6-alkinyloxy, C1-C6-alkoxycarbonyl or CN, whereby, with the exception of CN, the above-mentioned groups may be substituted by identical or different substituents; or R3 is aryl, heteroaryl, heterocyclyl, aryloxy, heteroaryloxy or heterocyclyloxy, whereby the above-mentioned groups may be substituted by identical or different substituents, R5 signifies hydrogen or methyl; have microbicidal, insecticidal and acaricidal activity and may be used to control insects and plant-pathogenic fungi in agriculture, horticulture and in the field of hygiene.Type: GrantFiled: December 13, 2000Date of Patent: August 20, 2002Assignee: Bayer AktiengesellschaftInventor: Hugo Ziegler
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Publication number: 20020102433Abstract: A compound of the following formula is described.Type: ApplicationFiled: November 28, 2001Publication date: August 1, 2002Inventors: Rong-Ho Lee, Chin-Ti Chen, Hsiu-Chih Yeh, Li-Hsin Chan
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Publication number: 20020099182Abstract: Compositions and methods are disclosed which facilitate purification of oligomers and other compounds. The disclosed compositions are silyl compositions that can be directly coupled, or coupled through a linking group, to a compound of interest, preferably to an oligomer at the end of oligomer synthesis. The silicon atom includes between one and three sidechains that function as capture tags. In one embodiment, the capture tags are lipophilic, which allows a derivatized oligomer to be separated from failure sequences by reverse phase chromatography. In another embodiment, the capture tags are compounds with a known affinity for other compounds, which other compounds are preferably associated with a solid support to allow chromatographic separation. Examples include haptens, antibodies, and ligands. Biotin, which can bind to or interact with a streptavidin-bound solid support, is a preferred capture tag of this type.Type: ApplicationFiled: July 18, 2001Publication date: July 25, 2002Inventor: Brian S. Sproat
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Patent number: 6420613Abstract: A method of preparing a reduced product by efficiently reducing an unsaturated organic compound by using, as a reducing agent, a trichlorosilane which is industrially cheaply available and is easy to handle, and a reducing agent therefor. A reduced product of an unsaturated organic compound is obtained by mixing the unsaturated organic compound and a trichlorosilane together to reduce the unsaturated organic compound in the presence of a compound that forms a silicon complex having five coordinations upon acting on the trichlorosilane such as an N-formylated product of a secondary amine having not less than 3 carbon atoms. The invention further provides a reducing agent comprising a particular silicon complex.Type: GrantFiled: December 11, 2000Date of Patent: July 16, 2002Assignee: Tokuyama CorporationInventors: Fumiaki Iwasaki, Yoshihiro Matsumura, Osamu Onomura, Kenji Tanaka
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Patent number: 6417187Abstract: 3-(Substituted aryl)-5-{substituted aryl-(alkynyl-aryl)}-[1,2,4]- triazole compounds are useful as insecticides and acaricides. New synthetic procedures and intermediates for preparing the compounds, pesticide compositions containing the compounds, and methods of controlling insects and mites using the compounds are also provided.Type: GrantFiled: April 13, 2001Date of Patent: July 9, 2002Assignee: Dow AgroSciences LLCInventors: Vidyadhar Babu Hegde, Scott Jerome Bis, Emilie Chassat Heo, Christopher Thomas Hamilton, Peter Lee Johnson, Laura Lee Karr, Timothy Patrick Martin, Paul Allen Neese, Nailah Orr, Francis Eugene Tisdell, Maurice Chee Hoong Yap, Yuanming Zhu
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Patent number: 6410768Abstract: The present invention is related to diimino compounds of formulae (I) R2—N═C(R1)(R3)nC(R1)═N—R2 and (II) (R1)2C═N—(CR24)m—N═C(R1)2 functionalized with at least one siloxy group. Said diimino compounds are useful for obtaining a solid catalyst component for polymerizing olefins wherein the diimino compound of formulae (I) or (II) is bonded to a porous inorganic support and to a transition metal selected from groups 8, 9 and 10 of the periodic table. This invention also relates to a process for preparing said diimino compounds of formulae (I) or (II), to a process for obtaining said solid catalyst component comprising the combination of the diimino compound and a porous inorganic support. Further, the invention also relates to the use of said solid catalyst in combination with a cocatalyst to polirnenrze olefins.Type: GrantFiled: March 12, 2001Date of Patent: June 25, 2002Assignee: Repsol Quimica S.A.Inventors: Luis Mendez Llatas, Antonio Muñoz-Escalona Lafuente, Juan Campora Perez, Ernesto Carmona Guzman, Manuel Lopez Reyes
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Patent number: 6403802Abstract: This invention provides a process for conducting amination reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in aminations of aryl halides and aryl pseudohalides. An amination can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than amino groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one primary amine and/or at least one secondary amine; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene.Type: GrantFiled: February 22, 2000Date of Patent: June 11, 2002Assignee: University of New Orleans Research & Technology FoundationInventors: Steven P. Nolan, Jinkun Huang, Mark L. Trudell, Chunming Zhang
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Patent number: 6403801Abstract: This invention provides a process for conducting Suzuki coupling reactions. The processes of the present invention make use of N-heterocyclic carbenes as ancillary ligands in Suzuki couplings of aryl halides and aryl pseudohalides. A Suzuki coupling can be carried out by mixing, in a liquid medium, at least one strong base; at least one aryl halide or aryl pseudohalide in which all substituents are other than boronic acid groups, wherein the aryl halide has, directly bonded to the aromatic ring(s), at least one halogen atom selected from the group consisting of a chlorine atom, a bromine atom, and an iodine atom; at least one arylboronic acid in which all substituents are other than chlorine atoms, bromine atoms, iodine atoms, or pseudohalide groups; at least one metal compound comprising at least one metal atom selected from nickel, palladium, and platinum, wherein the formal oxidation state of the metal is zero or two; and at least one N-heterocyclic carbene.Type: GrantFiled: February 22, 2000Date of Patent: June 11, 2002Assignee: University of New Orleans Research & Technology FoundationInventors: Steven P. Nolan, Jinkun Huang, Mark L. Trudell, Chunming Zhang
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Patent number: 6399783Abstract: The invention relates to a method for preparing an ester, by admixing a compound having the structure I or IV: with a base and an alcohol to produce an ester, wherein the alcohol is a precursor to Taxol and its analogs. The present invention also relates to compounds having the structure I and IV and methods of main them therefor. The invention also relates to the esterification of an alcohol by adding an alkoxide to a compound having the structure, VII: The invention further relates to compounds having the structure I, IV, and VII and methods of making them therefor. The invention further relates to alcohols, and in particular, alcohols that are synthetic precursors to Taxol and analogs thereof.Type: GrantFiled: August 25, 2000Date of Patent: June 4, 2002Assignee: Emory UniversityInventors: Dennis C. Liotta, Hariharan Venkatesan, Laura Captain, Michael V. Voronkov, James P. Snyder, Marcus A. Schestopol
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Patent number: 6387992Abstract: Compounds of formula I or II where R is a heteroaryl moiety, such as 3-pyridyl, or T is a heteroaryl moiety, such as thien-2,5-diyl, and E1 and E2 are independently hydrogen, alkyl, aralkyl and the like, are prepared by reaction of a benzotriazole substituted on the 5-position of the benzo ring by a halogen atom with a heteroarylboronic acid or ester in the presence of a transition-metal catalyst, such as palladium (II) diacetate. The benzotriazole compounds of formula I are particularly efficacious as stabilizers for automotive coatings and candle wax.Type: GrantFiled: November 27, 2000Date of Patent: May 14, 2002Assignee: Ciba Specialty Chemicals CorporationInventors: Stephen D. Pastor, Anthony DeBellis, Mervin G. Wood, Joseph Suhadolnik, Deborah DeHessa, Ramanathan Ravichandran
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Publication number: 20020055525Abstract: This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.Type: ApplicationFiled: June 11, 2001Publication date: May 9, 2002Inventors: John J. Talley, James A. Sikorski, Matthew J. Graneto, Jeffrey S. Carter, Bryan H. Norman, Balekudru Devadas, Hwang-Fun Lu
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Patent number: 6384229Abstract: Neutral, multidentate azacyclic ligands and Group 3-10 transition metal complexes that contain them are disclosed. The ligands have the general formula: Ra—A—(L)b where R is hydrogen or hydrocarbyl, A is silicon, tin, germanium, or lead, each L is a pyrazolyl, triazolyl, or tetraazolyl group, a=0 to 2, b=2 to 4, and a+b=4. When used with common activators, the transition metal complexes provide excellent single-site catalysts for olefin polymerization.Type: GrantFiled: October 4, 2000Date of Patent: May 7, 2002Assignee: Equistar Chemicals, L.P.Inventor: Gregory G. Hlatky
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Patent number: 6376669Abstract: Dye labeled imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds having immune response modulating activity are disclosed. The compounds are useful, inter alia, for determining the binding and/or receptor sites of the molecules.Type: GrantFiled: November 2, 2000Date of Patent: April 23, 2002Assignee: 3M Innovative Properties CompanyInventors: Michael J. Rice, Mark A. Tomai, Ai-Ping Wei
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Patent number: 6376679Abstract: Photoprotective, topically applicable sunscreen/cosmetic compositions well suited for the UV-photoprotection of human skin and/or hair, comprise an effective UV-photoprotecting amount of at least one novel benz-x-azole-substituted silane or siloxane having the formula (1) or (2): A—SiR′1R′2R′3 (2) in which A is a radical having the structural formula (I):Type: GrantFiled: December 20, 2000Date of Patent: April 23, 2002Assignee: Societe L'Oreal S.A.Inventors: Madeleine Leduc, HervĂ© Richard, Alain Lagrange
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Publication number: 20020045758Abstract: The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis) 1Type: ApplicationFiled: October 5, 2001Publication date: April 18, 2002Applicant: Rhone-Poulenc Inc.Inventors: Tai-Teh Wu, Alain Chene, David Treadway Manning, Peter Wyatt Newsome, Nicholas Charles Ray, Jennifer Lantz Phillips, Patrick Doyle Lowder
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Patent number: 6372914Abstract: The present invention provides an efficient stereoselective method for manufacturing (2S,4S)-2-[[(R)-hydroxy-(3R)-cyclic amine-3-yl]methyl]pyrrolidine-4-thiol or a salt thereof which is useful as an intermediate for the manufacture of carbapenem and also provides the intermediate. A method for manufacturing which comprises the step of reacting a compound of the formula (I): (wherein, R1 is a lower alkylsulfonyl group, an optionally substituted arylsulfonyl group or an alkylsilyl group; and R2 is a protecting group for an amino group) with a compound of the formula (II): (wherein, R3 is a substituted or unsubstituted lower alkyl group or aryl group; X is an oxygen atom or a sulfur atom; Y is an azide group or a nitro group; and m is an integer of 2 to 5).Type: GrantFiled: November 2, 2000Date of Patent: April 16, 2002Assignee: Eisai Co., Ltd.Inventors: Takaaki Suzuki, Isao Sugiyama, Manabu Sasho, Nobuaki Sato, Atsushi Kamada, Kazuhide Ashizawa
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Patent number: 6368395Abstract: The present invention is directed to methods of making subphthalocyanine compounds. The methods of the present invention may be used to produce known subphthalocyanine compounds, as well as, a new family of subphthalocyanine compounds. The methods of the present invention may employ environmentally-friendly solvents, which donate a hydrogen atom for use in the reaction mechanism. The methods of the present invention produce subphthalocyanine compounds at a yield of greater than about 50%, and even greater than about 94%. The present invention is further directed to subphthalocyanine compounds having improved lightfastness. The subphthalocyanine compounds may have a Subphth-Lightfastness Test Value of less than 15%.Type: GrantFiled: May 12, 2000Date of Patent: April 9, 2002Assignee: Kimberly-Clark Worldwide, Inc.Inventors: Ronald Sinclair Nohr, John G. MacDonald
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Patent number: 6350878Abstract: The invention relates to a method of synthesis for a compound of formula (I), wherein R is a heterocyclyl moiety and X1, X2, X3 and X4 are, independently of each other, protecting groups, which is appropriate for the synthesis of epothilone B and desoxyepothione B.Type: GrantFiled: November 17, 2000Date of Patent: February 26, 2002Assignee: Novartis AGInventors: Karl-Heinz Altmann, Armin Bauer, Dieter Schinzer