Boron Or Silicon Containing Patents (Class 548/110)
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Publication number: 20090227792Abstract: ?-aminoalkoxysilanes wherein the ?-amino group is a tertiary amino group, and which also contains a further reactive group, display excellent reactivity of the alkoxy groups while remaining stable with respect to decomposition and byproduct formation, particularly through cleavage of the Si-C bond. The ?-aminosilanes are particularly useful for preparing alkoxysilyl-terminated prepolymers which exhibit high cure rates in the presence of moisture, and for functionalizing particles reactive therewith.Type: ApplicationFiled: November 17, 2005Publication date: September 10, 2009Applicant: WACKER CHEMIE AGInventors: Christoph Briehn, Volker Stanjek, Richard Weidner
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Patent number: 7586015Abstract: A process is used for the preparation of 1,3,2-oxazaborolidine compounds. This process prepares compounds of formula (I) or (IA): in which: R1 is an alkyl or an aryl; and R2, R3, R4 and R5 are especially a hydrogen atom or an alkyl, wherein the following are reacted in two steps: a) a boric precursor compound with an acetal compound to give a boronate compound; and b) the boronate compound with an amino alcohol compound. This process avoids by-products and exhibits a very good stereospecificity.Type: GrantFiled: January 25, 2007Date of Patent: September 8, 2009Assignee: Zach SystemInventors: Alain Burgos, Stëphane Frein
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Publication number: 20090221762Abstract: The invention concerns compounds, oligomers, and polymers that contain: (I), (II), (III), or (IV) groups; where “-” indicates points of attachment.Type: ApplicationFiled: January 10, 2007Publication date: September 3, 2009Applicant: THE TRUSSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Michael J. Therien, Kimihiro Susumu
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Publication number: 20090216025Abstract: The present invention relates to new compositions and reactions to produce allylic alcohols or precursors of allylic alcohols (e.g., silyl ethers of allylic alcohols). Methods of the invention may comprise combining an alkene and an aldehyde in the presence of a transition metal catalyst (e.g., a nickel catalyst) to form an allylic alcohol or precursor of an allylic alcohol. Reaction products of the present invention may be valuable as intermediates and/or products in pharmaceutical and polymer research. Also, methods of the invention may be useful as fragment coupling reactions in complex molecule synthesis. Moreover, methods of the invention may include the use of reagents which, under reaction conditions known in the art, may have been unreactive, i.e., may not have been able to form the reaction product. The reagents used in the present invention may be relatively lower in cost than in other methods.Type: ApplicationFiled: August 30, 2006Publication date: August 27, 2009Applicant: Massachusetts Institute of TechnologyInventors: Timothy F Jamison, Sze-Sze Ng
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Publication number: 20090216009Abstract: An industrially easily realizable and economical process comprising only few steps, and built on new intermediates for the production of 1-(4-3(R)-[3(S)-(4-fluorophenyl)-3-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone (ezetimibe) according to the reaction scheme described herein.Type: ApplicationFiled: December 18, 2006Publication date: August 27, 2009Inventors: Jozsef Bodi, Janos Eles, Katalin Szoke, Krisztina Vukics, Tamas Gati, Krisztina Temesvari, Dorottya Kiss-Bartos
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Publication number: 20090197833Abstract: Silicon-containing compounds having selective COX-2 inhibitory activity, as well as compositions thereof are provided. The subject compounds find use in a variety of applications, including therapeutic applications. Also provided are kits containing the subject compounds and pharmaceutical preparations thereof.Type: ApplicationFiled: February 10, 2009Publication date: August 6, 2009Inventor: PATRICK ENGLEBIENNE
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Publication number: 20090192298Abstract: The present disclosure relates, according to some embodiments, to compositions, systems, and methods for preparing and using fluorescent through-bond energy transfer cassettes.Type: ApplicationFiled: November 13, 2008Publication date: July 30, 2009Inventor: Kevin Burgess
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Publication number: 20090181928Abstract: Compounds of the formula are inhibitors of protein tyrosine phosphatases (PTPases) and, thus, may be employed for the treatment of conditions mediated by PTPase activity. The compounds of the present invention may also be employed as inhibitors of other enzymes characterized with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula (I) may be employed for prevention and/or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels, conditions that accompany type-2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated.Type: ApplicationFiled: March 29, 2007Publication date: July 16, 2009Inventors: Alan Neubert, David Barnes, Young-Shin Kwak, Katsumasa Nakajima, Gregory Raymond Bebernitz, Gary Mark Coppola, Louise Kirman, Michael H. Serrano-Wu, Travis Stams, Sidney Wolf Topiol, Thalaththani Ralalage Vedananda, James Richard Wareing
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Publication number: 20090179638Abstract: Disclosed is an assay for identifying compounds that modulate a neuronal apoptotic pathway, the assay comprises: a) contacting HSP90 protein with a probe to form a probe: HSP90 complex, the probe being displaceable by a test compound; b) measuring a signal from the probe so as to establish a reference level; c) incubating the probe:HSP90 complex with the test compound; d) measuring the signal from the probe; e) comparing the signal from step d) with the reference level, a modulation of the signal indicating that the test compound binds to HSP90. Also disclosed is a probe which is labeled with a detectable label and/or an affinity tag.Type: ApplicationFiled: February 1, 2007Publication date: July 16, 2009Applicant: AEGERA THERAPEUTICS INC.Inventors: Philip A. Barker, James B. Jaquith, Stephen J. Morris, Amir Salehi
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Patent number: 7553560Abstract: Emissive phosphorescent organometallic compounds are described that produce improved electroluminescence, particularly in the blue region of the visible spectrum. Organic light emitting devices employing such emissive phosphorescent organometallic compounds are also described. Also described is an organic light emitting layer including a host material having a lowest triplet excited state having a decay rate of less than about 1 per second; a guest material dispersed in the host material, the guest material having a lowest triplet excited state having a radiative decay rate of greater than about 1×105 or about 1×106 per second and wherein the energy level of the lowest triplet excited state of the host material is lower than the energy level of the lowest triplet excited state of the guest material.Type: GrantFiled: May 6, 2008Date of Patent: June 30, 2009Assignees: The Trustees of Princeton University, The University of Southern California, Universal Display CorporationInventors: Sergey Lamansky, Mark E. Thompson, Vadim Adamovich, Peter I. Djurovich, Chihaya Adachi, Marc A. Baldo, Stephen R. Forrest, Raymond Kwong
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Publication number: 20090156554Abstract: New compounds of formula 1 are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.Type: ApplicationFiled: February 5, 2009Publication date: June 18, 2009Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Steffen BREITFELDER, Udo MAIER, Trixi BRANDL, Christoph HOENKE, Matthias GRAUERT, Alexander PAUTSCH, Matthias HOFFMANN, Frank KALKBRENNER, Anne T. JOERGENSEN, Gerhard SCHAENZLE, Stefan PETERS, Frank BUETTNER, Eckhart BAUER
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Publication number: 20090149425Abstract: The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other three of X1, X2, X3 and X4 each represent nitrogen or CR5, provided that 1 to 3 of X1, X2, X3 and X4 represent nitrogen, and Z represents oxygen, sulfur or NR6, which has pest-controlling activity.Type: ApplicationFiled: January 13, 2005Publication date: June 11, 2009Inventors: Hiromasa Mitsudera, Ken Otaka, Jun Fujiwara
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Publication number: 20090143598Abstract: Fluoroalkyl silanes are a class of compounds useful for various industrial purposes. For example, fluoroalkyl silanes which have hydrolysable groups (called hydrolysable fluoroalkyl silanes), are compounds useful as surface treatment agents which provide durable hydrophobic and oleophobic coatings. In general, hydrolysable fluoroalkyl silanes can be represented with the following formula: (RO—)3Si—RT wherein R is H or an alkyl; and RT is a monovalent organic compound terminated by a perfluoroalkyl group. When used to coat a surface, the (RO—)3 moiety reacts (via hydrolysis) with various chemical groups of the surface (e.g., hydroxyl, amine, or other reactive groups) thereby bonding the fluoroalkyl silane to the surface The RT moiety comprises a divalent organic linking group which links the silicon atom to a terminal group rich in fluorine atoms whose unique electronic properties impart desirable hydrophobic and oleophobic properties in a surface coating.Type: ApplicationFiled: November 26, 2008Publication date: June 4, 2009Inventors: Axel Hans-Joachim Herzog, Gerald Oronde Brown
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Publication number: 20090143597Abstract: Novel chemical compounds of the general formula K+A?, in which K+is a 5- or 6-membered heterocyclic ring having 1-3 hetereo atoms, which can be independently N, S, or O; with the proviso that at least one of the hetereo atoms must be a quaternized nitrogen atom having a —R?CN substituent, wherein R? is alkyl (C1 to C12); the heterocyclic ring having up to 4 or 5 substituents independently chosen from the moieties: (i) H; (ii) halogen or (iii) alkyl (C1 to C12), which is unsubstituted or partially or fully substituted by further groups, preferably F, Cl, N(CnF(2n+1?x)Hx)2, O(CnF(2n+1?x)Hx), SO2(CnF(2n+1?x)Hx)2 or CnF(2n+1?x)Hx where 1<n<6 and 0<x<13; and (iv) a phenyl ring which is unsubstituted or partially or fully substituted by further groups, preferably F, Cl, N(CnF(2n+1?x)Hx)2, O(CnF(2n+1?X)Hx), SO2(CnF(2n+1?x)Hx)2 or CnF(2n+1?x)Hx where 1<n<6 and 0<x?13; and A? is any anion that provides a salt with a low melting point, below about 100° C.Type: ApplicationFiled: August 25, 2004Publication date: June 4, 2009Applicant: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNEInventors: Paul Dyson, Dongbin Zhao, Zhaofu Fei
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Publication number: 20090134789Abstract: An organic electroluminescence device includes an anode; a cathode; and at least one organic layer, wherein the at least one organic layer includes a first organic layer which is a light-emitting layer being provided between the anode and the cathode and containing at least one light-emitting material, and the at least one organic layer contains at least one compound represented by formula (I): wherein Q1 represents an aromatic heterocyclic ring; each of R1, R2, R3 and R4 independently represents a hydrogen atom or a substituent; and each of R11, R12 and R13 independently represents an alkyl group, an aryl group, or an aromatic heterocyclic group, provided that at least one of R11, R12 and R13 represents an aryl group or an aromatic heterocyclic group.Type: ApplicationFiled: November 26, 2008Publication date: May 28, 2009Applicant: FUJIFILM CORPORATIONInventor: Toshihiro ISE
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Publication number: 20090137815Abstract: Disclosed are processes for making compounds containing 4- and 5-imidazolyl rings, also disclosed are the inter-mediates useful in the processes disclosed herein.Type: ApplicationFiled: April 16, 2007Publication date: May 28, 2009Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Rogelio Perez Frutos, Dhileepkumar Krishnamurthy, Nitinchandra D. Patel, Sonia Rodriguez, Chris Hugh Senanayake
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Publication number: 20090118512Abstract: 6,7-Dihydro-5H-imidazo[1,5-a]pyridin-8-one (I), is obtainable in high yields by: 1) a process which proceeds from a suitably protected C-(3-hydroxypyridin-2-yl)methylamine whose amine is converted to the formamide which is then cyclized to the imidazo[1,5-a]pyridine and hydrogenated to the 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one, and suitably protected C-(3-hydroxypyridin-2-yl)methylamines can be prepared either in 2 steps proceeding from commercially available 3-hydroxy-2-cyanopyridine [932-35-4] or in 3 steps proceeding from commercially available 2-hydroxymethylpyridin-3-ol [14173-30-9]; 2) a process for preparing 4-hydroxy-1-(1H-imidazol-4-yl)butan-1-one, an intermediate from the synthesis of 6,7-dihydro-5H-imidazo[1,5-a]pyridin-8-one (formula I), as described in WO 2002/040484, proceeding from N,N-dimethyl-2-(trialkylsilanyl)imidazole-1-sulphonamide by lithiation and subsequent reaction with a suitably protected 4-hydroxybutyraldehyde, followed by oxidation of the secondary alcohol, acid-induced deproType: ApplicationFiled: March 30, 2007Publication date: May 7, 2009Inventors: Pierre Martin, Andreas Boudier, Michael Quirmbach, Robert Mah, Nathalie Jotterand
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Publication number: 20090118511Abstract: The invention relates to a new process for preparing tiotropium salts of general formula 1 wherein X? may have the meanings given in the claims and in the specification.Type: ApplicationFiled: January 5, 2009Publication date: May 7, 2009Applicant: BOEHRINGER INGELHEIM PHARMA GMBH & CO., KGInventors: Ralf LOCK, Werner BELZER, Rainer HAMM, Monika HOFMANN
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Patent number: 7521435Abstract: Silicon-containing compounds having selective COX-2 inhibitory activity, as well as compositions thereof are provided. The subject compounds find use in a variety of applications, including therapeutic applications. Also provided are kits containing the subject compounds and pharmaceutical preparations thereof.Type: GrantFiled: February 16, 2006Date of Patent: April 21, 2009Assignee: Pharma Diagnostics, N.V.Inventor: Patrick Englebienne
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Organometalic compounds for electroluminescence and organic electroluminescent device using the same
Publication number: 20090078317Abstract: The present invention relates to electroluminescent compounds represented by Chemical Formula (1) L1L1M(Q)m and electroluminescent devices comprising the same as host material. The electroluminescent compound according to the invention, when used as host material of an OLED, noticeably lowers the operation voltage and enhance the power efficiency.Type: ApplicationFiled: September 5, 2008Publication date: March 26, 2009Applicant: Gracel Display Inc.Inventors: Hyun Kim, Young Jun Cho, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon -
Publication number: 20090082568Abstract: In a process for the accelerated reduction of organic substrates, selected from the group consisting of ester, amides, nitriles, acids, ketones, imines or mixtures thereof, the substrates are reacted with an amine borane, sulfide borane or ether borane complex as a borane source in the presence of organic accelerator compounds containing both Lewis acidic and Lewis basic sites in their structure, of which the Lewis acidic site can coordinate with the carbonyl or nitrile or imine group of the substrate and the Lewis basic site can coordinate with the borane.Type: ApplicationFiled: September 21, 2007Publication date: March 26, 2009Applicant: BASF AktiengesellschaftInventor: Elizabeth Burkhardt
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Publication number: 20090082308Abstract: The present invention relates to a novel class of benzothiophene amide derivatives. The hydroxamic acid compounds can be used to treat cancer. The benzothiophene amide compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention may also be useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases.Type: ApplicationFiled: April 14, 2006Publication date: March 26, 2009Inventors: Jed Lee Hubbs, Dawn M. Mampreian, Joey L. Methot, Thomas A. Miller, Karin M. Otte, Phieng Siliphaivanh, David L. Sloman, Matthew G. Stanton, Kevin J. Wilson, David J. Witter
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Publication number: 20090074682Abstract: The present invention relates to novel compounds of formula (1) and also to cosmetic compositions containing them and to the cosmetic uses thereof, in particular for protecting the skin against UV-induced oxidative stress.Type: ApplicationFiled: September 27, 2005Publication date: March 19, 2009Applicant: L'OREALInventor: Karine Lucet-Levannier
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Patent number: 7501522Abstract: Process for preparing purified 1,3-substituted imidazolium salts of the formula (I) by reacting a 1,3-substituted imidazolium salt of the formula (II), with a strong base at from 20 to 250° C. while distilling off the 1,3-substituted imidazol-2-ylidene formed, in which the 1,3-substituted imidazol-2-ylidene which has been distilled off is brought into contact in the gaseous state with the protic acid HaA (III) and/or the 1,3-substituted imidazol-2-ylidene which has been distilled off is passed in the gaseous or condensed state into a receiver comprising the protic acid HaA (III).Type: GrantFiled: June 30, 2004Date of Patent: March 10, 2009Assignee: BASF AktiengesellschaftInventors: Matthias Maase, Klemens Massonne
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Publication number: 20090036687Abstract: A multinuclear complex comprising a plurality of metal atoms and a ligand L coordinating to the metal atoms, and satisfying the following conditions (i), (ii), (iii) and (iv): (i) The ligand L has a monovalent group represented by the following general formula (1) and/or a divalent group represented by the following general formula (2), (ii) The ligand L has at least 5 coordination atoms bonding to the metal atom, (iii) At least one of the coordination atoms bonds to two of the metal atoms, or the minimum number of covalent bonds between any two selected coordination atoms is 1-5, and (iv) The ligand L is soluble in the solvent.Type: ApplicationFiled: February 8, 2007Publication date: February 5, 2009Inventors: Yoshiyuki Sugahara, Takeshi Ishiyama, Hideyuki Higashimura
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Publication number: 20090005528Abstract: In one aspect, the invention relates to silicon-based prepolymers. The disclosed prepolymers exhibit satisfactory solubility in aqueous solutions or hydrophilic solutions and can overcome undesirable shrinkage, expansion, and related problems possessed by conventional silicone monomers and related conventional polymerization techniques by producing hydrogels from a crosslinkable prepolymer. Also disclosed are polymers and molded articles produced from the disclosed prepolymers, which attain a satisfactory oxygen permeability. Also disclosed are methods for producing the disclosed prepolymers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: June 29, 2007Publication date: January 1, 2009Inventors: Kazuhiko Fujisawa, Mitsuru Yokota, Masataka Nakamura
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Publication number: 20090005344Abstract: Imidazole and benzimidazole boronic acid compounds, analogs thereof, and pharmaceutical formulations are described, along with methods of use thereof for inhibiting inflammatory cytokines such as tumor necrosis factor alpha (TNF-?) in a subject in need thereof.Type: ApplicationFiled: October 27, 2005Publication date: January 1, 2009Applicant: NKUADA, LLCInventors: James F. Burns, Leonardo A. Cabana, Glenn C. Collupy, John R. Didsbury, Tatyana A. Dyakonov, Simon N. Haydar, Michael L. Jones, Francine F. Li, Christopher J. Markworth, Jessymol Mathew, Frank J. Schoenen, David S. Van Vliet, David Middlemiss
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Publication number: 20090005557Abstract: The present invention provides a ?-electron-conjugated organice silane compound that give an organic thin film superior in peeling restance, orientation, crystallinity and eletroconductive properties, and a production method thereof. A ?-electron-conjugated organice silane compound represented by General Formula: R1-SiX1X2X3 (R1 represents an organic group having a particular monocyclic heterocyclic unit; and X1 to X3 are a group giving a hydroxyl group by hydrolysis). A method of producing the organic silane compound, comprising allowing a compound represented by General Formula: R1-Li (R1 is the same as above) or a compound represented by General Formula: R1-MgX5 (R1 is the same as above; and X5 represents a halogen atom) with a compound represented by General Formula: X4-SiX1X2X3 (X1 to X3 are the same as above; and X4 represents a hydrogen or halogen atom or a lower alkoxy group).Type: ApplicationFiled: July 4, 2005Publication date: January 1, 2009Inventors: Masatoshi Nakagawa, Hiroyuki Hanato, Toshihiro Tamura
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Patent number: 7462404Abstract: Novel boron complexes are blue emissive electroluminescent compounds.Type: GrantFiled: March 12, 2004Date of Patent: December 9, 2008Assignee: Merck Patent GmbHInventors: Poopathy Kathirgamanathan, Matthew Samuel Kirkham, Alexander Kit Lay, Subramaniam Ganeshamurugan, Gnanamoly Paramaswara, Muttulingam Kumaraverl, Arumugam Partheepan, Selvadurai Selvaranjan, Juan Antipan-Lara, Richard Price, Sivagnanasundram Surendrakumar
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Publication number: 20080280855Abstract: The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.Type: ApplicationFiled: June 20, 2006Publication date: November 13, 2008Applicant: NYCOMED GmbHInventors: Maria Vittoria Chiesa, Andreas Palmer, Wilm Buhr, Peter Jan Zimmermann, Christof Brehm, Wolfgang-Alexander Simon, Stefan Postius, Wolfgang Kromer, Antonio Zanotti-Gerosa
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Publication number: 20080261920Abstract: The invention relates to compounds of formula I wherein X, Y, R1, R2, and n are as defined herein or to a pharmaceutically suitable acid addition salt thereof. The invention also relates to pharmaceutical compositions containing such compounds and methods for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases include depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.Type: ApplicationFiled: January 25, 2008Publication date: October 23, 2008Inventors: Guido Galley, Katrin Groebke Zbinden, Roger Norcross, Henri Stalder
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Publication number: 20080261917Abstract: A compound of formula or a prodrug and/or a pharmaceutically acceptable salt thereof, wherein X is O, N or S; R1 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl; R2 is hydrogen, halo, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted hydroxyalkyl substituted or unsubstituted alkylamine, alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; R3 is hydrogen, halo, hydroxy, substituted or unsubstituted alloy substituted or unsubstituted hydroxyalkyl, substituted or unsubstituted alkylamine alkoxy, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroalkyl; and R4-R7, is used to represent groups R4, R5, R6 and R7 which are H, OH, alkyl, alkoxy, alkylamine, hydroxyalkyl, hType: ApplicationFiled: August 26, 2005Publication date: October 23, 2008Inventors: Hendrika Maria Gerarda Willems, Per Kallblad, Ian Robert Hardcastle, Robert John Griffin, Bernard Thomas Golding, John Lunec, Martin E.M. Noble, David R. Newell, Alan H. Calvert
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Publication number: 20080249290Abstract: Disclosed is a compound of the formula and dimers thereof, wherein R, R?, X, (Y)m, and (Z)n are as defined herein. The compounds are useful as colorants, particularly in applications such as phase change inks.Type: ApplicationFiled: April 4, 2007Publication date: October 9, 2008Inventors: Jeffrey H. Banning, James D. Mayo, Rina Carlini
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Publication number: 20080214829Abstract: The invention relates to salts having alkoxytris(fluoroalkyl)borate anions which on the one hand are used for the synthesis of ionic liquids, but on the other hand can be employed per se as ionic liquid, and to processes for the preparation thereof.Type: ApplicationFiled: July 9, 2005Publication date: September 4, 2008Inventors: Nikola (Mykola) Ignatyev, Urs Welz-Biermann, Maik Finze, Eduard Bernhardt, Helge Willner
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Publication number: 20080207853Abstract: Compounds are provided that are useful as precatlysts in the polymerization of olefins such as ethylene and propylene. Other compounds are useful as intermediates in the production of such precatalysts.Type: ApplicationFiled: February 23, 2007Publication date: August 28, 2008Inventors: Omofolami Tesileem Ladipo, Richard Eaves, Alexey Zazybin, Sean Parkin
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Publication number: 20080188442Abstract: Compounds of the formula I in which the substituents are as defined in claim 1 are suitable for use as microbiocides.Type: ApplicationFiled: July 17, 2006Publication date: August 7, 2008Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Clemens Lamberth, Camilla Corsi, Josef Ehrenfreund, Hans Tobler, Harald Walter
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Patent number: 7405304Abstract: The present invention provides methods for preparing complexed diaryl boronic acids from alkyl diarylborinates.Type: GrantFiled: January 9, 2003Date of Patent: July 29, 2008Assignee: The Penn State Research FoundationInventors: Ali Tavassoli, Stephen J. Benkovic
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Publication number: 20080161565Abstract: Process for preparing compounds of Formula (I); and (IV); are described.Type: ApplicationFiled: February 17, 2005Publication date: July 3, 2008Applicant: ASTRAZENECA ABInventors: Margaret Anne Butlin, Roger John Butlin, Philip John Hogan, Andreas Meudt
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Publication number: 20080161269Abstract: This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.Type: ApplicationFiled: December 19, 2007Publication date: July 3, 2008Applicants: ASTRAZENECA AB, ASTEX THERAPEUTICS LIMITEDInventors: Stefan Berg, Sofia Karlstrom, Karin Kolmodin, Johan Lindstrom, Jan-Erik Nystrom, Fernando Sehgelmeble, Peter Soderman
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Publication number: 20080146803Abstract: The structure and preparation of antibiotics incorporating borinic acid complexes are disclosed, especially hydroxyquinoline, imidazole and picolinic acid derivatives, along with compositions of these antibiotics and methods of using the antibiotics and compositions as bactericidal and fungicidal agents as well as therapeutic agents for the treatment of diseases caused by bacteria and fungi.Type: ApplicationFiled: September 6, 2007Publication date: June 19, 2008Inventors: Ving Lee, Stephen J. Benkovic
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Publication number: 20080146523Abstract: The invention relates to imidazole derivatives which have a good affinity to the trace amine associated receptors (TAARs), especially for TAAR1. The invention also relates to a pharmaceutically-suitable acid-addition salt of the above compound. The invention further relates to a composition comprising an imidazole derivative as described above, or a pharmaceutically-suitable acid-addition salt thereof, and to processes for preparing such compounds.Type: ApplicationFiled: December 5, 2007Publication date: June 19, 2008Inventors: Guido Galley, Katrin Groebke Zbinden, Roger Norcross, Henri Stalder
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Publication number: 20080146814Abstract: Process for the preparation of N-protected boryl compounds. The compounds are intermediates to functionalized compounds, both natural and synthetic which are cytotoxic, anticancer and antiviral agents.Type: ApplicationFiled: September 11, 2007Publication date: June 19, 2008Applicant: Board of Trustees of Michigan State UniversityInventors: Milton R. Smith, Robert E. Maleczka, Venkata A. Kallepalli, Edith Onyeozili
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Patent number: 7381479Abstract: Emissive phosphorescent organometallic compounds are described that produce improved electroluminescence, particularly in the blue region of the visible spectrum. Organic light emitting devices employing such emissive phosphorescent organometallic compounds are also described. Also described is an organic light emitting layer including a host material having a lowest triplet excited state having a decay rate of less than about 1 per second; a guest material dispersed in the host material, the guest material having a lowest triplet excited state having a radiative decay rate of greater than about 1×105 or about 1×106 per second and wherein the energy level of the lowest triplet excited state of the host material is lower than the energy level of the lowest triplet excited state of the guest material.Type: GrantFiled: May 3, 2005Date of Patent: June 3, 2008Assignees: The University of Southern California, The Trustees of Princeton University, Universal Display CorporationInventors: Sergey Lamansky, Mark E. Thompson, Vadim Adamovich, Peter I. Djurovich, Chihaya Adachi, Marc A. Baldo, Stephen R. Forrest, Raymond Kwong
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Publication number: 20080125396Abstract: The present invention relates to certain novel compounds of formula (I) to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) ? (NR1H3) and/or ? (NR1H2) and in treating and/or preventing clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.Type: ApplicationFiled: January 9, 2006Publication date: May 29, 2008Applicant: AtraZeneca ABInventors: Marianne Swanson, Kay Brickmann, Lanna Li
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Publication number: 20080112866Abstract: One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acidic group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronsted-acidic group to catalyze a Bronsted-acid-catalyzed chemical reaction. A third aspect of the present invention relates to ionic liquids comprising a pendant nucleophilic group, e.g., an amine. Still another aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to catalyze a nucleophile-assisted chemical reaction. A fifth aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to remove a gaseous impurity, e.g., carbon dioxide, from a gas, e.g., sour natural gas.Type: ApplicationFiled: April 24, 2007Publication date: May 15, 2008Applicant: University of South AlabamaInventor: James Hillard Davis
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Patent number: 7371868Abstract: Process for producing a 7-bromoquinolone-carboxylic acid derivative of the following formula or its salt by reacting a 2,4-dibromo-3-hydroxybenzoic acid ester compound of the formula R7a-x to obtain a 3-alkoxy-2,4-dibromobenzoic acid ester, subjecting the 3-alkoxy-2,4-dibromobenzoic acid ester to elimination reaction of the carboxyl-protecting group to obtain a 3-alkoxy-2,4-dibromobenzoic acid, subjecting the 3-alkoxy-2,4-dibromobenzoic acid to ketoesterification reaction to obtain a 3-alkoxy-2,4-dibromobenyolacetic acid ester, reacting the 3-alkoxy-2,4-dibromobenzoylacetic acid ester with an orthoester or an acetal, then reacting the reaction product with a compound of the formula R2—NH or its salt to obtain a 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester and subjecting the 2-(3-alkoxy-2,4-dibromobenzoyl)-3-substituted aminoacrylic acid ester to ring-closing reaction, and products thereof.Type: GrantFiled: March 27, 2007Date of Patent: May 13, 2008Assignee: Toyama Chemical Co., Ltd.Inventors: Katsuji Ojima, Tamotsu Takamatsu, Kyoko Taya, Taro Kiyoto
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Patent number: 7361678Abstract: This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, ?-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.Type: GrantFiled: March 5, 2003Date of Patent: April 22, 2008Assignee: TransTech Pharma, Inc.Inventors: Adnan M. M. Mjalli, Robert C. Andrews, Ramesh Gopalaswamy, Anitha Hari, Kwasi S. Avor, Ghassan Qabaja, Xiao-Chuan Guo, Suparna Gupta, David R. Jones, Xin Chen
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Patent number: 7358266Abstract: The invention relates to cis- and trans-12, 13-cyclopropyl and 12,13-cyclobutyl epothilones of formula I to IV wherein Ar is a radical represented by the following structure: and the other radicals and symbols have the meanings as defined herein; to their chemical synthesis and biological evaluation; their use in the treatment of neoplastic diseases and to pharmaceutical preparations containing such compounds. The compounds described herein are potent tubulin polymerization promoters and cytotoxic agents.Type: GrantFiled: August 23, 2002Date of Patent: April 15, 2008Assignee: The Scripps Research InstituteInventors: Kyriacos C. Nicolaou, Kenji Namoto, Andreas Ritzen, Mitsuru Shoji, Trond Ulven, Karl-Heinz Altmann
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Publication number: 20080038191Abstract: Positron emitting compounds and methods of their production are provided. The compounds have the formula: (F)m G (R)n wherein each R is a group comprising at least one carbon, nitrogen, phosphorus or sulfur atom and G is joined to R through said carbon, nitrogen, phosphorus or sulfur atom; G is silicon or boron; m is 2 to 5 and n is 1 to 3 with m+n=3 to 6 when G is silicon; m is 1 to 3 and n is 1 to 3 with m+n=3 to 4 when G is boron; and wherein the compound further comprises one or more counterions when the above formula is charged; and wherein at least one F is 18 F.Type: ApplicationFiled: February 14, 2005Publication date: February 14, 2008Inventors: David M. Perrin, Richard Ting
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Patent number: 7227026Abstract: Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4?-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.Type: GrantFiled: February 6, 2006Date of Patent: June 5, 2007Assignee: Teva Pharmaceutical Industries Ltd.Inventors: Gennady Nisnevich, Igor Rukhman, Boris Pertsikov, Julia Kaftanov, Ben-Zion Dolitzky