Boron Or Silicon Containing Patents (Class 548/110)
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Publication number: 20100197630Abstract: Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are potent CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In formula I, A-B is an arylamide moiety.Type: ApplicationFiled: June 16, 2008Publication date: August 5, 2010Inventors: Julianne A. Hunt, Rogelio L. Martinez, Peter J. Sinclair, Ramzi F. Sweis
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Publication number: 20100197633Abstract: A compound of general formula (I): A process for preparing this compound. A compound of general formula (II) A fungicide composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition comprising it.Type: ApplicationFiled: October 4, 2006Publication date: August 5, 2010Applicant: BAYER CROPSCIENCE S.A.Inventors: Darren Mansfield, Pierre-Yves Coqueron, Heiko Rieck, Philippe Desbordes, Alain Villier, Marie-Claire Grosjean-Cournoyer, Pierre Genix
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Publication number: 20100190981Abstract: The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.Type: ApplicationFiled: January 14, 2010Publication date: July 29, 2010Inventors: Jiacheng Zhou, Pingli Liu, Qiyan Lin, Brian W. Metcalf, David Meloni, Yongchun Pan, Michael Xia, Mei Li, Tai-Yuen Yue, James D. Rodgers, Haisheng Wang
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Publication number: 20100190749Abstract: The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.Type: ApplicationFiled: September 17, 2009Publication date: July 29, 2010Inventors: Pingda Ren, Yi Liu, Troy Edward Wilson, Liansheng Li, Katrina Chan
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THIAZOLE SYSTEM ORGANIC ELECTROLUMINESCENT COMPOUNDS AND ORGANIC LIGHT EMITTING DIODE USING THE SAME
Publication number: 20100190994Abstract: The present invention relates to novel thiazole system organic electroluminescent compounds and organic light emitting diodes comprising the same. Since the thiazole system organic electroluminescent compounds according to the invention have good luminous efficiency and life property, OLED's having very good operation lifetime can be produced.Type: ApplicationFiled: March 25, 2008Publication date: July 29, 2010Inventors: Mi Ae Lee, Hyuck Joo Kwon, Bong Ok Kim, Sung Min Kim, Seung Soo Yoon -
Publication number: 20100168359Abstract: Described herein are tri-functional compounds useful in the production of ophthalmic lenses. The compounds are composed of UV absorber having a polymerization initiator directly or indirectly bonded to the ultraviolet absorber, and an olefinic group directly or indirectly bonded to the ultraviolet absorber. Also described herein are polymers and ophthalmic lenses produced from the tri-functional compounds described herein.Type: ApplicationFiled: December 17, 2009Publication date: July 1, 2010Inventors: Angelika Maria Domschke, Lynn Cook Winterton, Troy Vernon Holland, Richard Charles Turek
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Patent number: 7744838Abstract: One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acidic group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronsted-acidic group to catalyze a Bronsted-acid-catalyzed chemical reaction. A third aspect of the present invention relates to ionic liquids comprising a pendant nucleophilic group, e.g., an amine. Still another aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to catalyze a nucleophile-assisted chemical reaction. A fifth aspect of the present invention relates to the use of an ionic liquid comprising a pendant nucleophilic group to remove a gaseous impurity, e.g., carbon dioxide, from a gas, e.g., sour natural gas.Type: GrantFiled: April 24, 2007Date of Patent: June 29, 2010Assignee: University of South AlabamaInventor: James H. Davis, Jr.
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Publication number: 20100160256Abstract: Provided are compounds represented by the following formula (A-1) and formula (1), or salts thereof. The compounds of formula (A-1) and formula (1) or salts thereof have 133 adrenergic receptor agonist activity, and thus are useful as therapeutic and prophylactic agent for diabetes mellitus, obesity, hyperlipidemia, depression, diseases caused by gallstones or hypermotility of the biliary tract, diseases caused by hyperactivity of the digestive tract, interstitial cystitis, overactive bladder or urinary incontinence, or as therapeutic and prophylactic agents for diseases concomitant with decreased tears.Type: ApplicationFiled: September 29, 2009Publication date: June 24, 2010Applicant: ASAHI KASEI PHARMA CORPORATIONInventors: Seiji Nakano, Taisuke Iwanami, Kei Yamanishi, Yasuhiro Wada, Akifumi Morimoto
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Patent number: 7737236Abstract: Polymers comprising repeating units of the formula I where the variables are defined as follows: a is an integer from 0 to 3, R1, R2, R3 are identical or different and are selected independently from among hydrogen, C1-C20-alkyl, C1-C20-alkyl containing one or more Si, N, P, O or S atoms, C6-C30-aryl, preferably C6-C14-aryl, C4-C14-heteroaryl, —N(C6-C14-aryl)2, and Y1, where Y1 may be identical or different and are selected from among —CH?CH2, trans- or cis-CH?CH—C6H5, acryloyl, methacryloyl, methylstyryl, O—CH?CH2 and glycidyl, where Y2 is selected from among —CH?CH2, trans- or cis-CH?CH—C6H5, acryloyl, methacryloyl, methylstyryl, —O—CH?CH2 and glycidyl, and one or more groups Y1 or Y2 may be crosslinked to one another.Type: GrantFiled: March 11, 2005Date of Patent: June 15, 2010Assignee: BASF AktiengesellschaftInventors: Reinhold Schwalm, Yvonne Heischkel, Horst Weiss
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Publication number: 20100145062Abstract: Tetrakis(1-imidazolyl)borate (BIm4) based zwitterionic and/or related molecules for the fabrication of PLEDs is provided. Device performances with these materials approaches that of devices with Ba/Al cathodes for which the cathode contact is ohmic. Methods of producing such materials, and electron injection layers and devices containing these materials are also provided.Type: ApplicationFiled: December 1, 2009Publication date: June 10, 2010Inventors: Huaping Li, Yunhua Xu, Guillermo C. Bazan
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Patent number: 7732617Abstract: Tocopherol derivatives having the general formula: wherein n is an integer of 6 to 13, R1 is hydrogen, a silyl ether or acetate, R2 is an optionally substituted nitrogen-containing heterocycle or a polycyclic nitrogen-containing heterocycle; and pharmaceutically acceptable salts thereof are provided. A method for synthesizing the compounds is also provided. The tocopherol derivatives are capable of inhibiting the primary enzyme responsible for the metabolism of the tocopherols and tocotrienols compounds of vitamin E, namely tocopherol-?-hydroxylase, and thus increase the amount and prolong the availability of these compounds in plasma and tissue.Type: GrantFiled: May 25, 2007Date of Patent: June 8, 2010Assignees: Brock University, Cornell UniversityInventors: Jeffrey Atkinson, Robert S. Parker, Stephan Ohnmacht, Phillip John Nava, Ryan West
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Publication number: 20100137249Abstract: The present disclosure encompasses compounds and compositions that are useful as specific AI-2 antagonists for the control of bacterial quorum sensing. Although the AI-2 antagonists according to the present disclosure may not have bactericidal effect, their ability to attenuate virulence, drug resistance, and/or biofilm formation have therapeutic benefits. In addition, the AI-2 antagonists of the present disclosure can also be used as tools to probe bacterial AI-2 functions. The present disclosure also encompasses methods for inhibiting or attenuating microbial virulence, biofilm formation, and drug resistance. The methods are suitable for preventing bacteria from accruing and forming extensive biofilms that may be a health or hygiene hazard or a physical issue, such as in the blockage of water or fuel lines.Type: ApplicationFiled: June 6, 2008Publication date: June 3, 2010Inventors: Binghe Wang, Nanting Ni, Junfeng Wang, Chung-Dar Lu, Han-Ting Chou, Minyong Li, Shilong Zheng, Yunfeng Cheng, Hanjing Peng
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Publication number: 20100137243Abstract: Compounds of Formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, and compounds as shown in Formula (I) wherein C is for example (D), (E), (F); wherein A and B are independently selected from (i) and (ii); R2a to R3b are independently selected from hydrogen and fluorine; R1a and R1b are independently selected from, for example, hydroxy, —NHC(?W)R4, (a) and (b); wherein W is O or S; R4 is, for example, hydrogen, amino, (1-4C)alkyl; HET-1 is, for example, a C-linked 5-membered heteroaryl ring; HET-2 is, for example, an N-linked 5-membered, fully or partially unsaturated heterocyclic ring; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.Type: ApplicationFiled: May 28, 2008Publication date: June 3, 2010Applicant: AstraZeneca ABInventors: Michael Barry Gravestock, Neil James Hales, Michael Lingrad Swaim, Sheila Irene Hauck, Stuart Dennett Mills
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Publication number: 20100120715Abstract: Disclosed herein are ?-aminoboronic acids and their derivatives which act as inhibitors of beta-lactamases. Also disclosed herein are pharmaceutical compositions comprising ?-aminoboronic acids and methods of use thereof.Type: ApplicationFiled: May 12, 2009Publication date: May 13, 2010Inventors: Christopher J. Burns, Randy W. Jackson, Rajesh Goswami, Hongyu Xu
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Publication number: 20100120714Abstract: Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein W is O or S; V is a direct bond or NR3; Q is or CR6aR6b, O, NR7, C?N—O—R7 or C(?O); Y is —C(R5)?N—O—(CR8aR8b)p—X—(CR9aR9b)q—SiR10aR10bR10c; or a phenyl ring substituted as defined in the disclosure; or Z; and R1, R2, R3, R4, R5, R6a, R7, R8a, R8b, R9b, R10a, R10b, R10c, Z, p and q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.Type: ApplicationFiled: April 4, 2008Publication date: May 13, 2010Applicant: E.I. DU PONT DE NEMOURS AND COMPANYInventors: Bruce Lawrence Finkelstein, Andrew Edmund Taggi, Jefrey Keith Long, Paula Louise Sharpe, Chi-ping Tseng, Stephen Frederick Mccann, Amy X. Ding, Steven Lewis Swann, JR.
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Patent number: 7714013Abstract: This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, ?-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.Type: GrantFiled: August 28, 2006Date of Patent: May 11, 2010Assignee: Transtech Pharma, Inc.Inventors: Adnan M. M. Mjalli, Robert C. Andrews, Ramesh Gopalaswamy, Anitha Hari, Kwasi A. Avor, Ghassan Qabaja, Xiao-Chuan Guo, Suparna Gupta, David R. Jones, Xin Chen
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Patent number: 7709635Abstract: One aspect of the present invention relates to “boronium” ions that are stable, hydrophobic, room-temperature ionic liquids. In certain embodiments, ionic liquids of the instant invention are represented by the formula [XnBY4?n]+(n?1)(n?1)Z?1, wherein X refers to a Lewis base, Y refers to a substituent covalently bonded to boron, Z?1 is a charge diffuse anion, and x is 2, 3 or 4. In certain embodiments, the ionic liquids of the instant invention are of the general type [X2BY2]+1Tf2N?1, wherein each X is independently a tertiary amine, a N-alkylimidazole or a pyridine; and each B—X bond is a B—N bond.Type: GrantFiled: May 19, 2006Date of Patent: May 4, 2010Assignee: University of South AlabamaInventor: James H. Davis, Jr.
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Patent number: 7700781Abstract: The invention relates to salts having alkoxytris(fluoroalkyl)borate anions which on the one hand are used for the synthesis of ionic liquids, but on the other hand can be employed per se as ionic liquid, and to processes for the preparation thereof.Type: GrantFiled: July 9, 2005Date of Patent: April 20, 2010Assignee: Merck Patent GmbHInventors: Nikola (Mykola) Ignatyev, Urs Welz-Biermann, Maik Finze, Eduard Bernhardt, Helge Willner
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Publication number: 20100094010Abstract: Processes for preparing compounds of Formula I and IV are described.Type: ApplicationFiled: October 16, 2009Publication date: April 15, 2010Applicant: AstraZeneca ABInventors: Margaret Anne Butlin, Roger John Butlin, Philip John Hogan, Andreas Meudt
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Patent number: 7687490Abstract: An objective of the present invention is to provide compounds that are effective against various resistant bacteria which cause current clinical problems, for example, pneumococci including penicillin resistant Streptococcus pneumoneae (PRSP), Haemophilus influenzae including bata-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae (BLNAR), and Moraxella (Branhamella) catarrhalis.Type: GrantFiled: April 12, 2006Date of Patent: March 30, 2010Assignee: Meiji Seika Kaisha, Ltd.Inventors: Takahisa Maruyama, Yuko Kano, Takashi Ando, Takehiko Sawabe, Nobuyoshi Baba, Hiromi Takata, Hisashi Suzuki, Kazuhiro Aihara, Toshiki Fujita
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Patent number: 7678798Abstract: The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.Type: GrantFiled: April 12, 2005Date of Patent: March 16, 2010Assignee: Incyte CorporationInventors: Chu-Biao Xue, Ganfeng Cao, Taisheng Huang, Lihua Chen, Ke Zhang, Anlai Wang, David Meloni, Rajan Anand, Joseph Glenn, Brian W. Metcalf
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Publication number: 20100060829Abstract: Organosilicon compounds are represented by the following formula: wherein R is a hydrolyzable group, R? is an alkyl having 1 to 4 carbon atoms, A is an alkylene having 1 to 6 carbon atoms, X is O or S, Y is —NH— or S, L1 and L2 are C or N, Z and M are —NH—, O or S, R1 to R11 are H, alkyl having 1 to 6 carbon atoms, alkoxy or fluoroalkyl, or amino, m is 1 to 3, and n is 0 to 3. R1 and R2 or R2 and R3 may bonded together. R5 and R6 or R9 and R10 may directly bond together. R4 and R7 or R8 and R11 may form a ring skeleton. Their production processes, pressure-sensitive adhesive compositions, self-adhesive polarizers and LCDs are also disclosed.Type: ApplicationFiled: September 3, 2009Publication date: March 11, 2010Applicant: Shin-Etsu Chemical Co., Ltd.Inventor: Kazuhiro Tsuchida
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Patent number: 7674911Abstract: Methods are described for the production of hydrogen-bis(chelato)borates of the general formula H[BL1L2] and of alkali metal-bis(chelato)borates of the general formula M[BL1L2] where M=Li, Na, K, Rb, Cs L1=—OC(O)—(CR1R2)n—C(O)O— or —OC(O)—(CR3R4)—O— where n=0 or 1, R1, R2, R3, R4 independently of one another denote H, alkyl, aryl or silyl, L2=—OC(O)—(CR5R6)n—C(O)O— or —OC(O)—(CR7R8)—O— where n=0 or 1, R5, R6, R7, R8 independently of one another denote H, alkyl, aryl or silyl, wherein the respective raw materials are mixed in solid form without the addition of solvents and are reacted. Lithium-bis(oxalato)borate, lithium-bis(malonato)borate, caesium-bis-(oxalato)borate, caesium-bis-(malonato)borate and the mixed salts lithium(lactato,oxalato)borate and lithium(glycolato,oxalato)borate for example may be produced in this way.Type: GrantFiled: March 14, 2007Date of Patent: March 9, 2010Assignee: Chemetall GmbHInventors: Ulrich Wietelmann, Uwe Lischka, Klaus Schade, Jan-Christoph Panitz
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Publication number: 20100051928Abstract: An organic electroluminescence device includes: a pair of electrodes; and at least one organic layer including a light emitting layer, the light emitting layer being provided between the pair of electrodes, wherein at least one layer of the at least one organic layer contains a compound represented by formula (1): wherein each of Z11 and Z12 independently represents an aromatic heterocyclic ring or an aromatic hydrocarbon ring; R11 represents a hydrogen atom or a substituent, provided that a plurality of R11s are the same or different; m represents an integer of 1 or more; and L1 represents a single bond or an m-valent linking group and is linked to any one of C atoms in R11, Z11 and Z12, provided that when m is 1, L1 does not exist.Type: ApplicationFiled: September 4, 2009Publication date: March 4, 2010Applicant: FUJIFILM CORPORATIONInventor: Eiji FUKUZAKI
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Patent number: 7671047Abstract: One embodiment of the invention relates to compounds of the formula I, in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification. Other embodiments of the invention relate to physiologically acceptable salts of the compounds of formula I, to processes for their preparation and to medicaments comprising these compounds. The compounds of the invention are suitable for use, for example, as hypolipidemics.Type: GrantFiled: June 18, 2003Date of Patent: March 2, 2010Assignee: Sanofi-Aventis Deutschland GmbHInventors: Gerhard Jaehne, Wendelin Frick, Stefanie Flohr, Andreas Lindenschmidt, Heiner Glombik, Werner Kramer, Hubert Heuer, Hans-Ludwig Schaefer
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Patent number: 7671078Abstract: The invention relates to isothiourea derivatives of formula I: wherein R1 is a residue of one of the following structures: where the variables are as defined in the claims of the invention, as well as processes for production of these compounds.Type: GrantFiled: February 25, 2005Date of Patent: March 2, 2010Assignee: Novartis AGInventors: Fraser Glickman, Markus Streiff, Gebhard Thoma, Hans-Günter Zerwes
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Patent number: 7670692Abstract: A cyclometalated transition metal complex very efficiently emits phosphorescent light and an organic electroluminescent device using the same. The transition metal complex is suitable for an organic layer of an organic electroluminescent device, can emit light with a wavelength of 400 to 650 nm, and can emit white light when used with a red emissive material or a green emissive material.Type: GrantFiled: February 6, 2006Date of Patent: March 2, 2010Assignee: Samsung Mobile Display Co., Ltd.Inventors: Das Rupasree Ragini, Seok Chang, Eun-Sil Han, Hee-Kyung Kim, Lyong-Sun Pu, Jong-Hyoup Lee
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Publication number: 20100041895Abstract: The present invention is directed to the synthesis and stabilization of neutral molecules containing homonuclear single or multiple bonds, methods of preparation, and uses thereof.Type: ApplicationFiled: June 18, 2009Publication date: February 18, 2010Applicant: University of Georgia Research Foundation, Inc.Inventors: Gregory H. Robinson, Yuzhong Wang
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Publication number: 20100041686Abstract: The invention relates to compounds of formula I wherein R1, R2, X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of such compounds. The compounds are useful for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.Type: ApplicationFiled: July 17, 2009Publication date: February 18, 2010Inventors: Guido Galley, Annick Goergler, Katrin Groebke Zbinden, Roger Norcross
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Publication number: 20100041162Abstract: The present invention relates to the tagging of Histidine in polypeptides with arylboronic acid tagging reagents. The present invention further describes methods and devices to identify proteins in a sample by isolating and identifying Histidine-comprising peptides from one protein sample or a pool of protein samples. The present invention further describes databases of Histidine-comprising peptides from in silico cleaved proteins and their use in the identification of proteins.Type: ApplicationFiled: October 26, 2007Publication date: February 18, 2010Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V.Inventors: Ralf Hoffmann, Helga Hummel, Volker Weiler
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Publication number: 20100029589Abstract: The invention relates to compounds of formula I wherein R1, R2, X, Y, and n are defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The invention also provides pharmaceutical compositions and methods of manufacture of such compounds. The compounds are useful for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases are depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.Type: ApplicationFiled: September 14, 2009Publication date: February 4, 2010Inventors: Guido Galley, Annick Goergler, Katrin Groebke Zbinden, Roger Norcross
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Patent number: 7655805Abstract: A method for synthesizing benzotriazole comprises acts of: preparing a first solvent comprising 2-(2-hydroxy-5-methylphenyl) benzotriazole, a basic agent and molecular sieves and a second solvent comprising 3-chloro-2-alkyl propylene; mixing the solvents; and heating the solvents. This method requires only one reaction vessel and produces few by-products, therefore is simpler and cheaper to produce. Furthermore, the molecular sieves are cheaper than catalysts in conventional reactions and may be recycled, giving even greater economic benefits.Type: GrantFiled: April 24, 2008Date of Patent: February 2, 2010Assignee: UFC CorporationInventors: Ling Lu, Po-Hsuan Wei, Chung-Ning Fan, Yu-Cheng Lee, Hui-Ling Yang, Yu-Chin Lee
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Patent number: 7651978Abstract: The present invention relates to selective-herbicidal compositions, characterized in that they contain an effective amount of the compound 2-(2-trifluoromethoxy-phenylsulphonylaminocarbonyl)-4-methyl-5-methoxy-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I) and/or of salts of the compound of the formula (I), and to the use of these compositions for the selective control of weeds in crops of cereals, in particular crops of wheat, and to methods for the selective control of weeds in crops of cereals by applying the compositions together with surfactants and/or customary extenders.Type: GrantFiled: March 21, 2003Date of Patent: January 26, 2010Assignee: Arysta LifeScience North America, LLCInventors: Dieter Feucht, Hans-Joachim Santel, Klaus Lürssen, Ingo Wetcholowsky, Peter Dahmen, Klaus-Helmut Müller
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Patent number: 7635595Abstract: The spectroscopic and photophysical properties of fluorescent probes comprising donor-acceptor derivatives comprising the boric acid group or a derivative of boric acid, B(OH)3 (or borate ion, BO(OH)2?1), arsenious acid, H3 AsO3 (or arsenite ion, H2AsO3?1), telluric acid, H6TeO6 (or tellurate ion, H5 TeO6?1) or germanic acid, Ge(OH)6 (or germanate ion, GeO(OH)3?1) are described. Method of using said probes are also provided.Type: GrantFiled: March 10, 2005Date of Patent: December 22, 2009Inventors: Joseph R. Lakowicz, Nicolas Dicesare
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Publication number: 20090312231Abstract: Silicic acid esters to which fragrances are bound, preferably as 1-aza-3,7-dioxabicyclo[3,3,0]octane compounds or as monocyclic oxazolidines and that are suitable for adding fragrance to detergents and cleaning agents because they release the bound fragrances in hydrolysis.Type: ApplicationFiled: June 17, 2009Publication date: December 17, 2009Applicant: Henkel AG & Co. KGaAInventors: Ursula Huchel, Thomas Gerke, Silvia Sauf, Claudia Klink
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Publication number: 20090306014Abstract: Provided herein are C-10 taxane carbamates and pharmaceutically acceptable derivatives thereof. In certain embodiments, provided herein are compounds, compositions and methods for treating cancer and taupathy.Type: ApplicationFiled: December 27, 2006Publication date: December 10, 2009Applicants: Acidophil llc, The Trustees of the University of PennsylvaniaInventors: Carlo Ballatore, Angelo J. Castellino, Amos B. Smith, III, Joel Desharnais, Chengzao Sun, Simon E. Aspland
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Publication number: 20090306016Abstract: Disclosed are compounds of formula R—X—Y that may be used to inhibit the action of fatty acid amide hydrolase (FAAH). Inhibition of fatty acid amide hydrolase (FAAH) will slow the normal degradation and inactivation of endogenous cannabinoid ligands by FAAH hydrolysis and allow higher levels of those endogenous cannabinergic ligands to remain present. These higher levels of endocannabinoid ligands provide increased stimulation of the cannabinoid CB1i and CB2 receptors and produce physiological effects related to the activation of the cannabinoid receptors. They will also enhance the effects of other exogenous cannabinergic ligands and allow them to produce their effects at lower concentrations as compared to systems in which fatty acid amide hydrolase (FAAH) action is hot inhibited. Thus, a compound that inhibits the inactivation of endogenous cannabinoid ligands by fatty acid amide hydrolase (FAAH) may increase the levels of endocannabinoids and, thus, enhance the activation of cannabinoid receptors.Type: ApplicationFiled: July 27, 2007Publication date: December 10, 2009Inventors: Alexandros Makriyannis, Spyridon P. Nikas, Shakiru O. Alapafuja, Vidyanand G. Shukla
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Patent number: 7625936Abstract: The present invention relates to dihydropyrazole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.Type: GrantFiled: March 10, 2006Date of Patent: December 1, 2009Assignee: Merck & Co. Inc.Inventors: Paul J. Coleman, Christopher D. Cox, George D. Hartman
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Publication number: 20090291918Abstract: The present invention provides boronic acid compounds, boronic esters, and compositions thereof that can modulate apoptosis such as by inhibition of proteasome activity. The compounds and compositions can be used in methods of inducing apoptosis and treating diseases such as cancer and other disorders associated directly of indirectly with proteasome activity.Type: ApplicationFiled: July 1, 2009Publication date: November 26, 2009Applicant: Cephalon, Inc.Inventors: Raffaella Bernardini, Alberto Bernareggi, Paolo G. Cassara, Sankar Chatterjee, Germano D'Arasmo, Sergio De Munari, Edmondo Ferretti, Mohamed Iqbal, Ernesto Menta, Patricia A. Messina McLaughlin, Ambrogio Oliva
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Patent number: 7622422Abstract: A method of preparing an ionic conducting gel in solid form, known as ionogel. The method includes a step of mixing an ionic liquid with at least one molecular precursor containing at least one hydrolyzable group, if necessary in the presence of an acid, such as a carboxylic acid. The mixture is subsequently left to stand for one or more days until a gel is formed by polycondensation of the molecular precursor(s). The gel contains the aforementioned ionic liquid and can be set, in particular in transparent monolithic solid form.Type: GrantFiled: July 2, 2004Date of Patent: November 24, 2009Assignees: Centre National de la Recherche Scientifique, Universite Montpellier II, Universite Blaise Pascal Clermont IIInventors: André Vioux, Jean Le Bideau, Marie-Alexandra Neouze, Fabrice Leroux
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Publication number: 20090270590Abstract: A surface-modified inorganic material and a preparation method thereof. A surface-modified inorganic material is provided which is obtained by allowing an organosilane compound having allyl or an allyl derivative to react with an inorganic material, particularly solid silica or ITO glass, in the presence of an acid and an organic solvent, to introduce an organic group into the inorganic material even at room temperature, as well as a preparation method thereof. The invention can effectively introduce the organic group into the inorganic material even at room temperature, and thus is very effective in introducing compounds having a thermally sensitive functional group, for example, natural compounds or proteins. It is possible to introduce various organic groups into an inorganic material and to separate and purify organic molecule-bonded organosilane compounds using a silica gel column to effectively bond them to inorganic materials. Accordingly, the invention is very useful in the chemical industry.Type: ApplicationFiled: May 16, 2006Publication date: October 29, 2009Applicant: Industry-Academic Cooperation Foundation Yonsei UniversityInventors: Chul-Ho Jun, Ye-Lim Yeon, Ji-Sung Lee, Young-Jun Park
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Publication number: 20090256121Abstract: An electrochromic compound represented by Formula (1), wherein R1 is an alkyl group, an alkenyl group, an aryl group, or a heterocyclic group; R2 and R3 are each a hydrogen atom or a substituent; X is N—R4, an oxygen atom, or a sulfur atom; and R4 is a hydrogen atom or a substituent; provided that at least one of R1-R4 has a partial structure represented by Formula (2), —Si(Y)nR?(3-n) ??Formula (2) wherein Y is a halogen atom or OR, R is an alkyl group, or an aryl group; R? is an alkyl group, an alkenyl group, an aryl group, or a heterocyclic group, and n is an integer of 1-3.Type: ApplicationFiled: April 7, 2009Publication date: October 15, 2009Applicant: KONICA MINOLTA HOLDINGS, INC.Inventors: Kaori ONO, Osamu ISHIGE, Takeshi HAKII, Akihito HISAMITSU
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Publication number: 20090258999Abstract: The invention relates to and their preparation and the production of Silicon-Isocyanates from Silicon-Urea-Azolides.Type: ApplicationFiled: October 27, 2006Publication date: October 15, 2009Inventors: Peter Bissinger, Wolf Steiger
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Patent number: 7601437Abstract: Organometalic compounds, having formula I or formula (II) can serve as host materials for an organic electroluminescent device. Furthermore, the organometallic compounds can also serve as green phosphorescent dopant material for display devices.Type: GrantFiled: January 28, 2005Date of Patent: October 13, 2009Assignee: AU Optronics Corp.Inventor: Cheng-Hung Lin
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Patent number: 7601859Abstract: Organometallic complexes comprising a trivalent lanthanide metal ion complexed with one or more polydentate ligands containing one or more pyrazolyl-derived groups, such as trispyrazolyl borate species, are useful in light emitting materials e.g., in electroluminescent flat panel displays. In the complexes, several classes of which are novel, a coordinate bond is formed between the metal and one of the nitrogen atoms of the pyrazolyl rings.Type: GrantFiled: May 18, 2004Date of Patent: October 13, 2009Assignee: Isis Innovation LimitedInventor: Victor Christou
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Publication number: 20090253905Abstract: The invention relates to a method for producing onium salts comprising alkyl anions or aryl sulfonate anions or alkyl carboxylate anions or acryl carboxylate anions by reacting an onium halide with an alkyl silyl ester or trialkyl silyl ester of an alkyl sulfonic acid or aryl sulfonic acid or an alkyl carboxylic acid or aryl carboxylic acid or the anhydrides thereof.Type: ApplicationFiled: November 18, 2005Publication date: October 8, 2009Inventors: Nikolai (Mykola) Ignatyev, Urs Weiz-Biermann, Andriy Kucheryna, Helge Willner
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Patent number: 7598389Abstract: Novel silylated carboxamides of the formula (I) in which R, L, R1, R3, R3, R4 and A are as defined in the description, a plurality of processes for preparing these compounds and their use for controlling unwanted microorganisms.Type: GrantFiled: November 6, 2004Date of Patent: October 6, 2009Assignee: Bayer Cropscience AGInventors: Ralf Dunkel, Hans-Ludwig Elbe, Benoit Hartmann, Alexander Klausener, Jörg Nico Greul, Ulrike Wachendorff-Neumann, Peter Dahmen, Karl-Heinz Kuck
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Publication number: 20090230362Abstract: An organic electronic or an optoelectronic device containing a conjugated oligoelectrolyte. In more particularized embodiments, the conjugated oligoelectrolyte is the charge injection or transport layer. The conjugated oligoelectrolyte can be positively or negatively charged, and used in conjunction in a device with either or high or low work function metal.Type: ApplicationFiled: January 26, 2009Publication date: September 17, 2009Inventors: Guillermo C. Bazan, Yunhua Xu, Renqiang Yang, Thuc-Quyen Nguyen
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Publication number: 20090227786Abstract: The invention relates, in general, to an improved process for the preparation of the compounds (3R,4S)-4-(4-(benzyloxy)phenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]azetidin-2-one and (3R,4S)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-azetidin-2-one, which are key intermediates for the synthesis of ezetimibe, as well as the use of these intermediates for the preparation of ezetimibe.Type: ApplicationFiled: December 22, 2006Publication date: September 10, 2009Inventors: Ana Gavalda I Escude, Jordi Bosch I Llado, Anton Vidal I Ferran, Eva Garcia Garcia
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Publication number: 20090227792Abstract: ?-aminoalkoxysilanes wherein the ?-amino group is a tertiary amino group, and which also contains a further reactive group, display excellent reactivity of the alkoxy groups while remaining stable with respect to decomposition and byproduct formation, particularly through cleavage of the Si-C bond. The ?-aminosilanes are particularly useful for preparing alkoxysilyl-terminated prepolymers which exhibit high cure rates in the presence of moisture, and for functionalizing particles reactive therewith.Type: ApplicationFiled: November 17, 2005Publication date: September 10, 2009Applicant: WACKER CHEMIE AGInventors: Christoph Briehn, Volker Stanjek, Richard Weidner