Benzene Ring Or Halogen Attached Directly To The Diazole Ring By Nonionic Bonding (e.g., 1-hydroxyethyl-4,5-diphenyl-imidazole; 1-ethyloxymethyl-2, 4,5-trichloro-imidazole, Etc.) Patents (Class 548/342.5)
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Publication number: 20140336232Abstract: The present invention relates to novel 2-iodoimidazole derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators.Type: ApplicationFiled: November 23, 2012Publication date: November 13, 2014Inventors: Hendrik Helmke, Sebastian Hoffmann, Carl Friedrich Nising, Alexander Sudau, Tomoki Tsuchiya, Jürgen Benting, Peter Dahmen, Ulrike Wachendorff-Neumann, David Bernier, Stephane Brunet, Marie-Claire Grosjean-Cournoyer, Hélène Lachaise, Philippe Rinolfi
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Publication number: 20140194620Abstract: The present invention relates to a precursor of positron emission tomography (PET) radioactive medical supplies, a preparation method thereof, and an application thereof, and more specifically, to a precursor having a tetravalent organic salt leaving group, a preparation method, and a method for preparing desired PET radioactive medical supplies in a high radiochemical yield within a short preparation time by introducing 18F using the same through a single step. The precursor having a tetravalent organic salt leaving group of the present invention can simplify the known complex multistep preparation of radioactive medical supplies into a single step, can save production costs because an excessive amount of a phase transfer catalyst is not required, facilitates separation of a compound after reaction, and enables rapid reaction velocity. The features are appropriate for the mass production of PET radioactive medical supplies by an automated synthesis system.Type: ApplicationFiled: May 11, 2012Publication date: July 10, 2014Applicant: FUTURECHEM CO., LTD.Inventors: Dae-Yoon Chi, Byoung-Se Lee, Chansoo Park, Min-Hyung Lee, Hyojin Cha, Woojin Cho, Heewon Kang, Kyunghun Kim
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Publication number: 20140163081Abstract: Compounds, pharmaceutically acceptable salts, isomers, or prodrugs thereof, of the invention are disclosed, which are useful as modulators of the activity of liver X receptors (LXR). Pharmaceutical compositions containing the compounds and methods of using the compounds are also disclosed.Type: ApplicationFiled: November 21, 2013Publication date: June 12, 2014Applicants: Exelixis Patent Company LLC, BRISTOL-MYERS SQUIBB COMPANYInventors: Brett B. Busch, William C. Stevens, JR., Ellen K. Kick, Haiying Zhang, Venkataiah Bollu, Richard Martin, Raju Mohan
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Publication number: 20140100373Abstract: The present invention provides an advantageous production method of an imidazole derivative, which is suitable for industrial production. Compound (VI) is produced by reacting compound (I) with a Grignard reagent or a magnesium reagent, and a lithium reagent, and then reacting the resulting compound with compound (V).Type: ApplicationFiled: June 14, 2012Publication date: April 10, 2014Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Yoichi Kawabata, Yasuhiro Sawai, Kazuaki Kanno, Naotaka Sawada
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Patent number: 8623942Abstract: The present invention provides a liquid curable epoxy resin composition that has excellent storage stability and curing properties and provides a cured product having excellent properties, particularly, excellent organic solvent resistance. For that purpose, a clathrate containing a carboxylic acid compound and at least one selected from the group consisting of an imidazole compound represented by formula (I), wherein R1 to R4 each represent a hydrogen atom or the like, and 1,8-diazabicyclo[5.4.0]undecene-7 (DBU) is mixed in an epoxy resin. The liquid curable epoxy resin composition uses a liquid epoxy resin or an organic solvent.Type: GrantFiled: March 9, 2010Date of Patent: January 7, 2014Assignee: Nippon Soda Co., Ltd.Inventors: Masami Kaneko, Kazuo Ono, Natsuki Amanokura, Naoyuki Kamegaya
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Publication number: 20130143929Abstract: Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein Q1, Q2, R1, R2, R3 and R4 are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling plant disease caused by a fungal pathogen comprising applying an effective amount of a compound or a composition of the invention.Type: ApplicationFiled: September 28, 2011Publication date: June 6, 2013Applicant: EI DU PONT DE NEMOURS AND COMPANYInventors: Jeffrey Keith Long, James Francis Bereznak, Moumita Kar, Andrew Edmund Taggi, Yuzhong Chen
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Publication number: 20130096315Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.Type: ApplicationFiled: September 12, 2012Publication date: April 18, 2013Inventors: Xiangping Qian, Andrew I. McDonald, Han-Jie Zhou, Luke W. Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David J. Morgans, JR., Bradley P. Morgan, Gustave Bergnes, Dashyant Dhanak, Steven D. Knight, Nicholas D. Adams, Cynthia A. Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
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Patent number: 8383829Abstract: An electrochromic compound represented by Formula (1), wherein R1 is an alkyl group, an alkenyl group, an aryl group, or a heterocyclic group; R2 and R3 are each a hydrogen atom or a substituent; X is N—R4, an oxygen atom, or a sulfur atom; and R4 is a hydrogen atom or a substituent; provided that at least one of R1-R4 has a partial structure represented by Formula (2), —Si(Y)nR?(3-n)??Formula (2) wherein Y is a halogen atom or OR, R is an alkyl group, or an aryl group; R? is an alkyl group, an alkenyl group, an aryl group, or a heterocyclic group, and n is an integer of 1-3.Type: GrantFiled: April 7, 2009Date of Patent: February 26, 2013Assignee: Konica Minolta Holdings, Inc.Inventors: Kaori Ono, Osamu Ishige, Takeshi Hakii, Akihito Hisamitsu
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Publication number: 20120004377Abstract: It is an object of the present invention to provide a clathrate that suppresses a curing reaction at low temperature to promote an improvement in storage stability (one-component stability), and can effectively cure a resin by heating treatment. A clathrate suitable for the clathrate is a clathrate containing (b1) at least one selected from the group consisting of an aliphatic polyvalent carboxylic acid, 5-nitroisophthalic acid, 5-tert-butylisophthalic acid, 5-hydroxyisophthalic acid, isophthalic acid, and benzophenone-4,4?-dicarboxylic acid; and (b2) at least one selected from the group consisting of an imidazole compound represented by the following formula (I), and 1,8-diazabicyclo[5.4.0]undecene-7, at a molar ratio of 1:1.Type: ApplicationFiled: March 15, 2010Publication date: January 5, 2012Inventors: Masami Kaneko, Kazuo Ono
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Patent number: 7915426Abstract: New 1,2,3- or 1,2,3,4- or 1,2,3,4,5- substituted imidazolium salts and their uses as solvent in catalyzed organic reactions, as well as compositions containing them and a transition metal compound. They can be used in the following reactions: the telomerisation of conjugated dienes, dimerisation of olefins, the oligomerisation of olefins, polymerization of olefins, alkylation of olefins, hydrogenation of olefins, olefin metathesis, hydroformylation of olefins, ring-closing metathesis of olefins, ring-opening metathesis polymerisation of olefins, symetric or asymetric epoxidation of olefins (including heteroatom substituted olefins) and the cyclopropanation of olefins, condensation reaction, hydrogenation reaction, isomerization reaction, Suzuki cross-coupling reactions, amination reaction, partial oxidation of alkancs, kinetic resolution of racemic mixtures, hydrogenation of imines, hydrogenation of ketones, transfer hydrogenation and hydroxylation of aromatic organic compounds.Type: GrantFiled: October 25, 2001Date of Patent: March 29, 2011Assignee: Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Yves Chauvin, Lionel Magna, Gerald Peter Niccolai, Jean-Marie Basset
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Publication number: 20110065728Abstract: The present invention provides pharmaceutical compositions containing benzene compound(s) represented by General Formula (1) below and, particularly, LPL-activating compositions for use in hyperlipidemia therapeutic and preventive agents, anti-obesity agents, and the like: wherein R1, R2, R3 and R4 are as defined in the specification.Type: ApplicationFiled: May 14, 2008Publication date: March 17, 2011Applicant: OTSUKA PHARMACEUTICAL FACTORY, INC.Inventors: Irina Neagu, Michael Ohlmeyer, Vidyadhar M. Paradkar, Kurt W. Saionz, Koushi Iwata, Takashi Okamura, Tadao Shibutani
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Publication number: 20100331380Abstract: Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of ?-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.Type: ApplicationFiled: June 29, 2009Publication date: December 30, 2010Inventors: Luke A. Esposito, F. Michael Hudson, Thomas Lake, Joel Cummings, Manfred Weigele, Alan Snow, Lesley Larsen
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Publication number: 20100240906Abstract: Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.Type: ApplicationFiled: March 26, 2010Publication date: September 23, 2010Inventors: Mark S. Bednarz, Hugh Alfred Burgoon, JR., Shinya Iimura, Ramanaiah C. Kanamarlapudi, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang
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Publication number: 20100234374Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts and tautomers thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. They are also useful for treating neurodegenerative diseases, mental retardation, schizophrenia, inflammatory diseases, restenosis, immune disorders, diabetes, cardiovascular disorders and asthma.Type: ApplicationFiled: December 21, 2006Publication date: September 16, 2010Inventors: Philip Jones, Jesus Maria Ontoria Ontoria, Rita Scarpelli, Raffaele Ingenito, Carsten Schultz-Fademrecht
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Patent number: 7750032Abstract: The invention provides trisubstituted pyrazoles and imidazoles of Formula I: wherein L2, q, R13, R14, R15, R16, Z1 and Z2 are as described in the Summary of the Invention; and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the peroxisome proliferator-activated receptor (PPAR) families, particularly the activity of PPAR?.Type: GrantFiled: February 3, 2006Date of Patent: July 6, 2010Assignee: IRM LLCInventors: Christopher Cow, Robert Epple, Xing Wang, Yongping Xie, Hans Martin Seidel
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Publication number: 20090186930Abstract: The invention concerns novel imidazole derivatives of general formula (I), wherein Z? and Z represent different variable groups. Said products have an antitumoral activity. The invention also concerns pharmaceutical compositions containing said products and their use for preparing antitumoral medicine.Type: ApplicationFiled: April 26, 2007Publication date: July 23, 2009Applicant: Societe de Conseils de Recherches et D' Applications Scientifiques (S.C.R.A.S.)Inventors: Anne-Marie Liberatore, Dennis Bigg, Dominique Pons, Grégoire Prevost
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Publication number: 20090137591Abstract: The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of the Peroxisome Proliferator-Activated Receptor (PPAR) families, particularly the activity of PPAR?.Type: ApplicationFiled: February 3, 2006Publication date: May 28, 2009Applicant: IRM LLCInventors: Christopher Cow, Robert Epple, Xing Wang, Yongping Xie, Hans Martin Seidel
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Patent number: 7026357Abstract: Compound of formula (I): and medicinal products containing the same are useful as dual ?2/5-HT2c antagonist receptors.Type: GrantFiled: June 7, 2004Date of Patent: April 11, 2006Assignee: Les Laboratoires ServierInventors: Gilbert Lavielle, Olivier Muller, Mark Millan, Anne Dekeyne, Mauricette Brocco
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Patent number: 6759387Abstract: This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidino or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length (SEQ ID NO:50).Type: GrantFiled: July 30, 2002Date of Patent: July 6, 2004Assignee: Cellgate, Inc.Inventors: Jonathan B. Rothbard, Paul A. Wender, P. Leo McGrane, Lalitha V. S. Sista, Thorsten A. Kirschberg
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Patent number: 6528535Abstract: The present invention provide compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.Type: GrantFiled: July 23, 2001Date of Patent: March 4, 2003Assignee: Warner-Lambert CompanyInventors: Jack Bikker, Ellen Myra Dobrusin, Annette Marian Doherty, Matthew Drowns, James Stanley Kaltenbronn, Juergen Kleinschroth, Dennis Joseph McNamara, John Quin, III, Joseph Thomas Repine, Marcin Stasiak
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Patent number: 6524770Abstract: A hexaaryl biimidazole compound useful as a photoinitiator, represented by Formula (I): wherein each R group represents an alkyl group which may be the same or different, and each X group is independently a fluorine or hydrogen. The compound (I) is particularly useful as an initiator in a photosensitive composition containing a polyimide precursor, which is curable under patternwise low radiation exposure to give a patterned layer having heat and chemical resistance.Type: GrantFiled: September 15, 2000Date of Patent: February 25, 2003Assignee: Hitachi Chemical Co., Ltd.Inventors: Takahiro Hidaka, Makoto Kaji
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Patent number: 6426360Abstract: A class of compounds is described for treating inflammation and inflammation-related disorders.Type: GrantFiled: May 15, 2000Date of Patent: July 30, 2002Assignee: G D Searle & Co.Inventors: Richard M Weier, Paul W Collins, Michael A Stealey, Thomas E Barta, Renee M Huff
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Patent number: 6407258Abstract: The invention relates to a process for the preparation of compounds of the formula (I) in which R(2) and R(3) independently of one another are —SR(4) or —COOR(5) and R(1), R(4) and R(5) have the meaning indicated in the description, which comprises cyclizing compounds of the formula II in which R(1), R(2) and R(3) have the meaning defined above, in the presence of alkylphosphonic anhydrides to give compounds of the formula (I), then purifying these in as is known per se by salt formation and, if appropriate, subsequent recrystallization and optionally removing radicals introduced for the protection of other functional groups in a manner known per se; and their use as intermediate for the synthesis of active compounds.Type: GrantFiled: July 26, 2000Date of Patent: June 18, 2002Assignee: Aventis Pharma Deutschland GmbHInventors: Bernd Napierski, Heinz-Peter Rebenstock, Wolfgang Holla
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Patent number: 6395724Abstract: Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like.Type: GrantFiled: June 7, 1999Date of Patent: May 28, 2002Assignee: Advanced Medicine, Inc.Inventors: J. Kevin Judice, Deborah L. Higgins, John H. Griffin
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Patent number: 6201001Abstract: Compounds of formula I inhibit celluar proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.Type: GrantFiled: August 2, 1999Date of Patent: March 13, 2001Assignee: Abbott LaboratoriesInventors: Le Wang, Qun Li, Hing L. Sham, Keith W. Woods