Two Double Bonds Between Ring Members Of The Diazole Ring (i.e., Imidazole) Patents (Class 548/335.1)
  • Patent number: 11917897
    Abstract: A polymer blend, including at least one organic semiconductor (OSC) polymer and at least one photosensitizer, such that the at least one OSC polymer is a diketopyrrolopyrrole-fused thiophene polymeric material, wherein the fused thiophene is beta-substituted.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: February 27, 2024
    Assignee: CORNING INCORPORATED
    Inventors: Mingqian He, Xin Li, Yang Li, Hongxiang Wang
  • Patent number: 11905547
    Abstract: A dry reagent composition that includes an active redox enzyme that oxidizes an analyte as a specific substrate to produce an inactive reduced form of the enzyme; and a salt of ferricyanide provides improved performance in electrochemical test strips such as those used for detection of glucose. The salt of ferricyanide consists of ferricyanide and positively-charged counter ions, and the positively charged counter ions are selected such that the salt of ferricyanide is soluble in water, and such that the salt of ferricyanide or the crystalline phase of the salt of ferricyanide has a solubility in water and/or a lower E0eff at a concentration of 100 mM than potassium ferricyanide. For example, the salt of ferricyanide may be tetramethylammonium ferricyanide.
    Type: Grant
    Filed: August 27, 2020
    Date of Patent: February 20, 2024
    Assignee: AgaMatrix, Inc.
    Inventors: Ian Harding, Mary Y. Lee, Sandie Tan
  • Patent number: 11814547
    Abstract: Provided is a polishing liquid composition that is able to improve the polishing rate of a silicon oxide film in one aspect. An aspect of the present disclosure relates to a polishing liquid composition for a silicon oxide film. The polishing liquid composition contains cerium oxide particles (component A), an additive (component B), and an aqueous medium. The component B is a compound having a reduction potential of 0.45 V or more when a 10 ppm aqueous solution of the component B is measured by cyclic voltammetry (with an Ag/AgCl electrode as a reference).
    Type: Grant
    Filed: September 18, 2019
    Date of Patent: November 14, 2023
    Assignee: KAO CORPORATION
    Inventors: Haruhiko Doi, Norihito Yamaguchi, Masato Sugahara, Takanao Seike, Masaki Inoue
  • Patent number: 11702516
    Abstract: This invention relates to a curative composition and its use in curing epoxy resins and prepregs, adhesives and moulded materials derived therefrom. The curative composition comprises a clathrate comprising a host component and a guest component, the host comprising a carboxylic acid or ester compounds as defined or phenolphthalin and the guest comprising an imidazole or imidazoline component.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: July 18, 2023
    Assignee: HEXCEL COMPOSITES LIMITED
    Inventors: David Allan Tilbrook, Christopher Robert Mason, Martin Richard Simmons
  • Patent number: 11639922
    Abstract: Systems and methods are provided for characterizing shuttle capture events in a nanopore sensor. The method first collects time-dependent current blockage signatures for at least one bias voltage. The method then identifies each signature as corresponding to a permanent or transient event. The method then generates a protein dynamics landscape (PDL) for the transient event signatures. The PDL comprises a set of histograms of nanopore current data and characterizes current through the nanopore during shuttle capture events. The method can then comprise identifying an entrance level blockage value based on the permanent event signatures. Permanent event captures can be determined by time duration which is larger than a certain threshold time value. Applying a between the fluidic chambers above a threshold voltage level can be used to control that the vast majority of events are permanent.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: May 2, 2023
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Lene V. Hau, Jene A. Golovchenko
  • Patent number: 10991984
    Abstract: A nonaqueous electrolyte of the present invention includes an ionic liquid including a first alicyclic quaternary ammonium cation having one or more substituents, a second alicyclic quaternary ammonium cation having an alicyclic skeleton that is the same as an alicyclic skeleton of the first alicyclic quaternary ammonium cation, and a counter anion to the first alicyclic quaternary ammonium cation and the second alicyclic quaternary ammonium cation and an alkali metal salt. In the second alicyclic quaternary ammonium cation, one of substituents bonded to a nitrogen atom in the alicyclic skeleton is a substituent including a halogen element. In the ionic liquid, the amount of a salt including the second alicyclic quaternary ammonium cation is less than or equal to 1 wt % per unit weight of the ionic liquid, or is less than or equal to 0.8 wt % per unit weight of the nonaqueous electrolyte.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: April 27, 2021
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Toru Itakura, Kyosuke Ito, Rie Yokoi, Jun Ishikawa
  • Patent number: 10774431
    Abstract: An anion-conducting polymeric membrane comprises vinylbenzyl-Rs and a substituted ethene. Rs is a positively charged cyclic amine group. The total weight of the vinylbenzyl-Rs groups is greater than 15% of the total weight of the membrane. In a preferred embodiment, the membrane is a Helper Membrane that increases the faradaic efficiency of an electrochemical cell into which the membrane is incorporated, and also allows product formation at lower voltages than in cells without the Helper Membrane.
    Type: Grant
    Filed: November 12, 2017
    Date of Patent: September 15, 2020
    Assignee: Dioxide Materials, Inc.
    Inventors: Richard I. Masel, Syed Dawar Sajjad, Qingmei Chen
  • Patent number: 10723859
    Abstract: This invention relates to a method for extracting valorized compounds from lignin by contacting lignins with an ionic liquid and/or a deep eutectic solvent and adding a catalyst and/or a biocatalyst to assist in breaking down the source material. Converting lignin into high value chemicals adds revenues for a bio-refinery and helps to improve the economic viability of biofuel production.
    Type: Grant
    Filed: July 17, 2018
    Date of Patent: July 28, 2020
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Jian Shi, Lalitendu Das, Enshi Liu, Joseph C. Stevens
  • Patent number: 10677532
    Abstract: Cooling medium comprising an ionic liquid with a hydrogen content of 0% to 8.5% by weight. The cooling medium can be used in a method for cooling a technical device, examples of which include: metallurgical ovens and their aggregates, ovens and aggregates in the glass and ceramic producing industry, ovens and aggregates in the cement producing industry, reactors and aggregates in gasification of organic matter and biofeedstocks, ovens and aggregates in incineration plants, reactors and aggregates in nuclear power plants, and combustion chambers and aggregates in conventional thermal power plants.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: June 9, 2020
    Assignee: PROIONIC GMBH
    Inventor: Roland Kalb
  • Patent number: 10323101
    Abstract: An object is to provide a method for producing a polysaccharide derivative without using a catalyst, a cocatalyst, or an active compound by esterification, etherification, or the like, from a polysaccharide such as cellulose as a source material, while maintaining a high molecular weight. Another object is to provide a method for producing a cellulose derivative in a separated condition directly from biomass containing lignocellulose. A method for producing a polysaccharide derivative of the present invention is characterized in that a reaction is carried out in a mixture comprising: a source material comprising a polysaccharide; an ionic liquid for which the pKa of a conjugate acid of an anion in DMSO is 12 to 19 and which is capable of producing a carbene; and a chain or cyclic ester compound or an epoxy compound. Preferably as a source material containing a polysaccharide, a biomass source material containing lignocellulose is used.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: June 18, 2019
    Assignees: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY, KANAZAWA INSTITUTE OF TECHNOLOGY
    Inventors: Ryohei Kakuchi, Kazuaki Ninomiya, Yoshiki Shibata, Kiyoshi Uzawa, Tomoki Ogoshi, Katsuhiro Maeda, Tomoyuki Ikai, Kenji Takahashi
  • Patent number: 10138209
    Abstract: The invention relates to a process for purifying an ionic liquid comprising dialkylimidazolium ions by means of stripping, wherein water vapor is used at a particular temperature. The process according to the invention is characterized in that the decomposition of the ionic liquid is minimized during the procedure of the process.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: November 27, 2018
    Assignee: Evonik Degussa GmbH
    Inventors: Matthias Bahlmann, Olivier Zehnacker, Markus Lütkehaus, Benjamin Willy, Werner Escher, Xinming Wang, Rolf Schneider, Christoph Hiller, Stefan Münzner
  • Patent number: 10000457
    Abstract: The present invention relates to a process of synthesis of certain ionic liquids di-polymerized based Radziszewsky type reaction, whereby primary amines containing at least one terminal functional group, for example —OH, aldehydes and a mineral or organic acid, react exothermically in a single step, thus resulting in an ionic liquid by condensation, then oxirane derivative molar quantities are added, by controlling the temperature and pressure a di-polymerized ionic liquid is obtained. The process of the present invention is advantageous because it provides a synthesis scheme for di-polymerized ionic liquids, primarily using short reaction times and high performance; this process can be further scaled for industrial production and it can accept alternative chemical precursors of lower cost.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: June 19, 2018
    Assignee: Instituto Mexicano del Petróleo
    Inventors: Alma Delia Miranda Olvera, José Manuel Domínguez Esquivel, Miguel Ángel Vázquez Guevara, Fabiola Irene López Vallejo
  • Patent number: 9809889
    Abstract: A process for oxidizing water using hydrated cobalt molybdenum is disclosed. A plurality of hydrated cobalt molybdenum nanoparticles are supported on an electrode and are able to catalytically interact with water molecules generating oxygen. The catalyst can be used as part of an electrochemical or photo-electrochemical cell for the generation of electrical energy.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: November 7, 2017
    Assignee: Toyota Motor Engineering & Manufacturing North America, Inc.
    Inventors: Kenneth James McDonald, Hongfei Jia
  • Patent number: 9771326
    Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: September 26, 2017
    Assignee: BIOGEN MA INC.
    Inventors: Hairuo Peng, Zhili Xin, Lihong Sun, Timothy Chan, Gnanasambandam Kumaravel, Arthur G. Taveras
  • Patent number: 9751841
    Abstract: The present invention is a novel process for the preparation of chalcogenone compounds by conversion of ionic liquids and salts comprising nitrogen-containing heterocyclic cations and basic anions to the corresponding nitrogen-containing heterocyclic chalcogenones by reaction with elemental chalcogens.
    Type: Grant
    Filed: March 30, 2010
    Date of Patent: September 5, 2017
    Assignee: Petroliam Nasional Berhad
    Inventors: Robin Don Rogers, John Holbrey, Hector Rodriguez
  • Patent number: 9732040
    Abstract: The application pertains to a process comprising a) acidifying a carbohydrate to a pH below 2; b) heating the mixture from step a) to a temperature from about 60° C. to about 100° C.; c) adding a catalyst to the mixture from step b) over a time from about 10 minutes to about 200 minutes; d) heating the mixture from step c) to a temperature from about 121° C. to about 140° C. and to a pressure of about 4.5 Kg/cm2 to about 5.3 Kg/cm2 over a time from about 15 minutes to about 90 minutes; and e) maintaining the mixture of step d) at a temperature from about 121° C. to about 140° C. and a pressure of about 4.5 Kg/cm2 to about 5.3 Kg/cm2 over a time from about 1 minute to about 300 minutes.
    Type: Grant
    Filed: January 31, 2014
    Date of Patent: August 15, 2017
    Assignee: Corn Products Development, Inc.
    Inventors: Hongxin Jiang, Felipe Torres Diaz, Brad Carnish, Jose Angel Contreras, Juan Carlos Rico, Jesus Adrian Guerra Martinez
  • Patent number: 9382816
    Abstract: Embodiments of the invention relate to a method for operating a steam cycle process performed in an apparatus having an evaporator or steam generator for the evaporation of a liquid working medium and an expander, which is lubricated by a lubricant, for the performance of mechanical work. The method comprises a) supplying the liquid working medium to the evaporator, in which it evaporates and is fed to the expander in the form of steam; b) supplying an ionic liquid, which at room temperature forms two liquid phases with the liquid working medium, to the expander as a lubricant; and c) separating the ionic liquid forming the lubricant for the expander from the working medium upstream of the evaporator.
    Type: Grant
    Filed: May 24, 2011
    Date of Patent: July 5, 2016
    Assignee: MAN Truck & Bus AG
    Inventors: Raimund Almbauer, Roland Kalb, Roland Kirchberger, Josef Klammer
  • Patent number: 9096540
    Abstract: Process for preparing 1,3-disubstituted imidazolium salts of the formula I where R1 and R3 are each, independently of one another, an organic radical having from 1 to 20 carbon atoms, R2, R4 and R5 are each, independently of one another, an H atom or an organic radical having from 1 to 20 carbon atoms, X is the anion of a hydrogen acid having a pKa of at least 2 (measured at 25° C., 1 bar in water or dimethyl sulfoxide) and n is 1, 2 or 3, wherein a) an ?-dicarbonyl compound, an aldehyde, an amine and the hydrogen acid of the anion X? are reacted with one another and b) the reaction is carried out in water, a solvent which is miscible with water or a mixture thereof.
    Type: Grant
    Filed: December 8, 2008
    Date of Patent: August 4, 2015
    Assignee: BASF SE
    Inventors: Michael Siemer, Georg Degen, Peter Groll
  • Patent number: 9090567
    Abstract: Process for preparing salts K+ X?, where K+ is an organic cation and X? is an anion, by anion exchange, wherein a salt K+ Y?, where K+ is as defined above and Y? is an organic anion having a carboxylate, sulfonate or sulfate group, is used as starting material and K+ Y? is reacted with a hydrogen acid HX whose pKa is less than the pKa of the hydrogen acid HY and after the reaction, the salt K+ X? obtained and the hydrogen acid HY obtained are present in separate liquid phases.
    Type: Grant
    Filed: March 13, 2012
    Date of Patent: July 28, 2015
    Assignee: BASF SE
    Inventors: Michael Klein, Michael Siemer, Diana Fürst, Günter Forster
  • Patent number: 9023850
    Abstract: Disclosed are compounds of Formula 1, N-oxides, and salts thereof, wherein Z is O or S; A1, A2, A3 and A4 are independently N or CR1, provided that only one of A1, A2, A3 and A4 is N; and R1, R2, R3 and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling a parasitic nematode comprising contacting the parasitic nematode or its environment with a biologically effective amount of a compound or a composition of the invention.
    Type: Grant
    Filed: October 5, 2011
    Date of Patent: May 5, 2015
    Assignee: E I du Pont de Nemours and Company
    Inventors: George Philip Lahm, Thomas Francis Pahutski, Jr.
  • Publication number: 20150119564
    Abstract: Methods for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a N-methylimidazole and methods for making oligonucleotides using N-methylimidazole are provided. In one embodiment, a method for removing 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from a feedstock containing N-methylimidazole includes contacting the feedstock with small or medium pore molecular sieves. The small or medium pore molecular sieves adsorb 1,3,5-trimethylhexahydro-1,3,5-triazine and N-methylenemethanamine from the feedstock. The method further includes separating the small or medium pore molecular sieves from the feedstock.
    Type: Application
    Filed: August 28, 2014
    Publication date: April 30, 2015
    Inventors: Venkatraman Mohan, Sandra M. Lorenz, Gregory Gajda
  • Publication number: 20150119577
    Abstract: A membrane separation process using a highly fluorinated polymer membrane that selectively permeates water of an aqueous ionic liquid solution to provide dry ionic liquid. Preferably the polymer is a polymer that includes polymerized perfluoro-2,2-dimethyl-1,3-dioxole (PDD). The process is also capable of removing small molecular compounds such as organic solvents that can be present in the solution. This membrane separation process is suitable for drying the aqueous ionic liquid byproduct from precipitating solutions of biomass dissolved in ionic liquid, and is thus instrumental to providing usable lignocellulosic products for energy consumption and other industrial uses in an environmentally benign manner.
    Type: Application
    Filed: October 29, 2014
    Publication date: April 30, 2015
    Applicant: CMS TECHNOLOGIES HOLDINGS, INC.
    Inventors: Daniel Campos, Andrew Edward Feiring, Sudipto Majumdar, Stuart Nemser
  • Publication number: 20150118104
    Abstract: Compounds and compositions are used as corrosion inhibitors for pipelines for crude oil containing water with high salt concentrations. The inhibitors are ionic liquids, imidazoles, benzotriazoles, and mixtures thereof. The composition includes two or more members of the inhibitors with a solvent. The inhibitors reduce corrosion of metallic surfaces of the pipelines containing crude oil having 0.2 and 40 wt % water, 10,000 to 70,000 ppm salt, and 9 to 600 ppm hydrogen sulfide. A synergic effect is provided by two or more different inhibitors. This synergy is derived from interactions with the metallic surface, among themselves or with the corrosive medium depending on the chain length, to inhibit the corrosion with decrease of the formulation dose. The composition can be a ternary formulation of the three families or two components of one family and a third component of a different family.
    Type: Application
    Filed: October 28, 2014
    Publication date: April 30, 2015
    Inventors: Jesus MARIN CRUZ, Araceli VEGA PAZ, Luisa Elena MONTIEL SANCHEZ, Salvador CASTILLO CERVANTES, Rafael MARTINEZ PALOU, Arquimedes ESTRADA MARTINEZ, Luis Manuel QUEJ AKE, Jose Luis Rodolfo BENITEZ AGUILAR, Veronica SANCHEZ GARCIA
  • Patent number: 9018321
    Abstract: Resin compositions which contain a compound having at least two epoxy and/or thiirane groups in the molecule (ingredient (1)) and a specific ionic liquid (ingredient (2)), as combined, are practicable resin compositions which comprise constitutive elements of readily available materials and have well-balanced suitable curing capability and storage stability. Preferably, the ionic liquid (ingredient (2)) comprises a combination of an ammonium cation or phosphonium cation and a carboxylate anion.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: April 28, 2015
    Assignee: Ajinomoto Co., Inc.
    Inventors: Hiroshi Amano, Shigeru Kawahara
  • Publication number: 20150105560
    Abstract: The invention relates to formulations comprising ionic organic compounds for use in electron transport layers or electron collecting layers of organic electronic (OE) devices, more specifically in organic photovoltaic (OPV) devices, to electron transport layers comprising or being made through the use of such formulations, and to OE and OPV devices comprising such formulations or electron transport layers.
    Type: Application
    Filed: April 12, 2013
    Publication date: April 16, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Stephane Berny, Amy Phillips, Priti Tiwana, Toby Cull, Miguel Carrasco-Orozco, Nicolas Blouin
  • Patent number: 9006279
    Abstract: The present disclosure relates to therapeutic compositions comprising substituted imidazoliums having multiple acidic groups. The compounds may be used to treat diseases or conditions such as those associated with bone, cancer, or pain. Compositions, dosage forms, methods of treating diseases or conditions, methods of preparation, and other related embodiments related to the substituted imidazoliums are also described herein.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: April 14, 2015
    Assignee: Antecip Bioventures II LLC
    Inventor: Herriot Tabuteau
  • Patent number: 9000188
    Abstract: The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: April 7, 2015
    Assignee: Trustees of Dartmouth College
    Inventors: Tadashi Honda, Emilie David, Dale Mierke
  • Publication number: 20150090639
    Abstract: Ionic liquids of the general formula C+A? where C+ represents an organic cation, specifically, but not limited to the imidazolium, pyridinium, isoquinolinium, ammonium types, which have aliphatic and aromatic substituents, while A? represents a carboxylate, aromatic and aliphatic anion. The ionic liquids are synthesized under conventional heating or microwave irradiation This invention is also related to the application of ionic liquids to remove sulfur compounds of naphthas through a liquid-liquid extraction and the recovery and reuse of ionic liquids by the application of heat, reduced pressure and washing with solvents.
    Type: Application
    Filed: December 8, 2014
    Publication date: April 2, 2015
    Inventors: Rafael Martinez Palou, Natalya Victorovna Likhanova, Eugenio Alejandro Flores Oropeza, Diego Javier Guzman Lucero
  • Patent number: 8993611
    Abstract: The invention relates to a family of stable polyamine arylethylamide compounds, and to the use of these compounds as agents inhibiting DNA damages induced by by-products of the non-enzymatic glycosylation of skin tissues. The invention also relates to cosmetic or dermocosmetic compositions intended to fight skin disorders associated with said glycosylation by-products.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: March 31, 2015
    Assignee: Exsymol
    Inventor: Marie-Christine Seguin
  • Patent number: 8969349
    Abstract: Provided herein are compounds of formula A-L-B, and pharmaceutically acceptable salts and stereoisomers thereof, wherein A is R1 and R2 together with the carbon atoms to which they are attached form a 1,2-phenylene ring optionally substituted with one or more R11; L is —C(R6)2—C(R6)2—; B is a heteroaromatic group defined herein; and -A1-A2- , A3, R11 and R6 are defined herein. Also disclosed are methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: March 3, 2015
    Assignee: Sunovion Pharmaceuticals Inc.
    Inventors: John Emmerson Campbell, Michael Charles Hewitt, Philip Jones, Linghong Xie
  • Patent number: 8962861
    Abstract: The present invention provides a catalyst composition and a method for preparing an amide. The catalyst composition of the present invention including a hydroxylamine salt, sulfuric acid, and a nitrogen-containing heterocyclic compound is used for catalyzing a ketoxime to form an amide in the Beckman rearrangement reaction. The preparation of an amide by using the catalyst composition of the present invention has high conversion rate of a ketoxime, high selectivity of an amide and high tolerance to water.
    Type: Grant
    Filed: January 27, 2012
    Date of Patent: February 24, 2015
    Assignee: China Petrochemical Development Corporation
    Inventors: Chien-Chuan Shih, Cheng-Fa Hsieh, Hung-Hung Hseuh, Tung-Han Tsai
  • Publication number: 20150045266
    Abstract: A composition including an ionic liquid alkyl ammonium salt (e.g., tetraalkylammonium cation and bis(trifluoromethanesulfonyl)imide anion) or an ionic liquid imidazolium salt (e.g., 1,3-dialkylimidazolium cation and bis(trifluoromethanesulfonyl)imide anion), that have a structure sufficient to exhibit at least partial solubility in one or more Group I-V base stocks. The disclosure also relates to a lubricating oil base stock and lubricating oil containing the composition, a multifunctional functional fluid containing the composition, and a method for improving solubility of an ionic liquid in a lubricating oil by using as the lubricating oil a formulated oil including a lubricating oil base stock as a major component, and an ionic liquid alkylammonium salt cobase stock, or an ionic liquid imidazolium salt cobase stock, as a minor component.
    Type: Application
    Filed: November 14, 2013
    Publication date: February 12, 2015
    Applicant: ExxonMobil Research and Engineering Company
    Inventors: Abhimanyu Onkar Patil, Satish Bodige, Tezcan Guney
  • Patent number: 8946442
    Abstract: Foams of ionic compounds are described. Methods of making the foams are also provided. The foams are ionic and can be used for catalysis, separations, gas storage, biosensors, electronics, and electrochemical applications.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: February 3, 2015
    Assignee: E I du Pont de Nemours and Company
    Inventors: Mark Brandon Shiflett, Akimichi Yokozeki
  • Publication number: 20150027928
    Abstract: Methylcarbonate-based ionic liquids (LIs) or carboxylates, derived from aliphatic or aromatic carboxylic acids are provided for the extraction of nitrogen compounds from hydrocarbon mixture (HCs) by liquid-liquid selective extraction, at room temperature and atmospheric pressure, where the LIs are immiscible with the HCs. This process is performed through an extraction by stifling two phases, followed by separation, or in a continuous flow system where the nitrogenous compounds are transferred to the phase formed by the LI and the total nitrogen content is substantially reduced in the HCS phase. The ionic liquids have the general formula C+A?, where: C+ is a heterocyclic organic cation, or quaternary ammonium-based; and A? is a methylcarbonate- or carboxylates-based anion, derived from aliphatic or aromatic carboxylic acids.
    Type: Application
    Filed: July 23, 2014
    Publication date: January 29, 2015
    Inventors: Natalya Victorovna LIKHANOVA, Rodolfo Juventino MORA VALLEJO, Georgina Cecilia LAREDO SANCHEZ, Irina Victorovna LIJANOVA, Bernando RODRIGUEZ HEREDIA
  • Patent number: 8940763
    Abstract: Disclosed herein are pharmaceutical compositions comprising a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of treating a patient suffering from overactive bladder, the method comprising identifying a patient in need thereof, and administering to the patient a therapeutically effective amount of extended release solifenacin, or a pharmaceutically acceptable salt thereof, and a therapeutically effective amount of pilocarpine, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 9, 2012
    Date of Patent: January 27, 2015
    Assignee: TheraVida, Inc.
    Inventors: Mehdi Paborji, Wendy Jade Limayo Hernandez, Kenneth L. Duchin, Roger S. Flugel
  • Publication number: 20150007963
    Abstract: Cooling medium comprising an ionic liquid with a hydrogen content of 0% to 8.5% by weight and its use.
    Type: Application
    Filed: December 28, 2012
    Publication date: January 8, 2015
    Applicant: VTU Holding GmbH
    Inventor: Roland Kalb
  • Patent number: 8927738
    Abstract: This invention is directed to compounds of formula I having the structure which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: January 6, 2015
    Assignee: H. Lundbeck A/S
    Inventors: Ask Puschl, Jacob Nielsen, Jan Kehler, John Paul Kilburn, Mauro Marigo, Morton Langgard
  • Patent number: 8927737
    Abstract: The present process purifies a salt Cat+X?, where Cat+ is any cation and X? is an organic anion having at least 6 carbon atoms. The salt is an impurity in a composition comprising a water-soluble salt (Cat+)nYn?, where Yn? is an inorganic anion or an organic anion, different from X?, with at most 10 carbon atoms. The process involves converting X? into an acid HX by adding an acid (H+)mZm?, forming two phases: an organic phase comprising HX and an aqueous phase comprising the water-soluble salts (Cat+)mZm? and (Cat+)nYn? or acids (H+)nYn?. The organic phase is separated and the aqueous phase passes over a basic anion exchanger which binds Zm? and Yn? and liberates OH?, giving an aqueous mixture comprising Cat+OH?. The organic phase and the aqueous mixture are converted into Cat+X? and H2O, optionally with addition of further HX.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: January 6, 2015
    Assignee: BASF SE
    Inventors: Michael Siemer, Michael Klein, Sunghee Son, Klemens Massonne, Uwe Vagt
  • Publication number: 20140377667
    Abstract: The invention relates to lithium-2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate, to the use thereof as conductive salt in lithium-based energy accumulators, and ionic liquids comprising 2-methoxy-1,1,2,2-tetrafluoro-ethanesulfonate as an anion.
    Type: Application
    Filed: July 25, 2012
    Publication date: December 25, 2014
    Applicants: JACOBS UNIVERSITY BREMEN gGMBH, WESTFALISCHE WILHELMS UNIVERSITAT MUNSTER
    Inventors: Gerd-Volker Roschenthaler, Martin Winter, Katja Vlasov, Nataliya Kalinovich, Christian Schreiner, Raphael Wilhelm Schmitz, Romek Ansgar Muller, Rene Schmitz, Alexandra Lex-Balducci, Miriam Kunze
  • Patent number: 8916564
    Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
    Type: Grant
    Filed: September 19, 2013
    Date of Patent: December 23, 2014
    Assignee: Pfizer Inc.
    Inventors: Martin Youngjin Pettersson, Douglas Scott Johnson, Chakrapani Subramanyam, Christopher John O'Donnell, Christopher William am Ende, Michael Eric Green, Nandini Chaturbhai Patel, Cory Michael Stiff, Tuan Phong Tran, Gregory Wayne Kauffman, Antonia Friederike Stepan, Patrick Robert Verhoest
  • Patent number: 8895559
    Abstract: A variety of specific compounds within the scope of formula I which are useful as PI3K inhibitors and can be employed for the treatment of autoimmune diseases, inflammation, cardiovascular diseases, neurodegenerative diseases and tumours, and pharmaceutical compositions and kits containing said specific compounds.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: November 25, 2014
    Assignee: Merck Patent GmbH
    Inventors: Markus Klein, Ulrich Emde, Hans-Peter Buchstaller, Christina Esdar, Oliver Poeschke
  • Patent number: 8883801
    Abstract: The present invention relates to certain pyrazolo[1,5-a]pyrimidine compounds of Formula (I) as inhibitors of mammalian Target Of Rapamycin (mTOR) kinase, which is also known as FRAP, RAFT, RAPT or SEP. The compounds may be used in the treatment of cancer and other disorders where mTOR is deregulated. The present invention further provides pharmaceutical compositions comprising the pyrazolo[1,5-a]pyrimidine compounds.
    Type: Grant
    Filed: August 22, 2011
    Date of Patent: November 11, 2014
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Lianyun Zhao, Duan Liu, Shuyi Tang, Amit K. Mandal, Umar Faruk Mansoor, Lalanthi Dilrukshi Vitharana, Panduranga Adulla P. Reddy, M. Arshad Siddiqui
  • Patent number: 8877759
    Abstract: The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula I: wherein the variables are as defined herein.
    Type: Grant
    Filed: September 4, 2012
    Date of Patent: November 4, 2014
    Assignee: Vertex Pharnaceuticals Incorporated
    Inventors: Jean-Damien Charrier, David Kay, Somhairle MacCormick, Pierre-Henri Storck, Joanne Pinder, Michael Edward O'Donnell, Ronald Marcellus Alphonsus Knegtel, Stephen Clinton Young, Philip Michael Reaper, Steven John Durrant, Heather Clare Twin, Christopher John Davis
  • Publication number: 20140309114
    Abstract: Amine salts of certain herbicides that in free acid form include at least one carboxylic acid moiety are described. Herbicide salts comprising the cation of various imidazole, piperazine, piperidine, and morpholine compounds are provided. The herbicide amine salts described are suitable for formulation into herbicidal application mixtures and/or stable concentration compositions that exhibit acceptable volatility characteristics upon application.
    Type: Application
    Filed: October 26, 2012
    Publication date: October 16, 2014
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventors: Junhua Zhang, Daniel R. Wright, William Abraham
  • Publication number: 20140305844
    Abstract: The ionic liquid for desulfurization of light fuels is 1-methyl-3-pentyl 1H-imidazolium periodate, having the structural formula: The compound is prepared by mixing 1-methyl-3-pentyl 1H-imidazolium tetrafluoroborate with sodium periodate in dichloromethane and water, stirring the mixture for 24 hours, and extracting the compound from the product with dichloromethane. The ionic liquid may be used for the desulfurization of light fuels by bringing the ionic liquid into contact with the crude light petroleum oil at a temperature of about 50° C. with stirring for a period of time sufficient to oxidize the sulfur containing impurities to water soluble sulfones, washing the mixture with water to remove the ionic liquids and water soluble sulfones, and drying the desulfurized light fuel product.
    Type: Application
    Filed: April 10, 2013
    Publication date: October 16, 2014
    Applicants: KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY, KING FADH UNIVERSITY OF PETROLEUM AND MINERALS
    Inventors: KING FADH UNIVERSITY OF PETROLEUM AND MINERALS, KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY
  • Patent number: 8853417
    Abstract: A non-halogen active agent for a flux is a sulfonate formed by a sulfonic acid reacting with an organic base. The sulfonic acid can be an alkyl sulfonic acid, alkyl disulfonic acid, hydroxyl sulfonic acid or halogenated sulfonic acid. The organic base can be an organic amine, carbamidine, imidazole, phosphorus. The non-halogen active agent for a flux has the advantage of high activity and low corrosion.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: October 7, 2014
    Assignee: Hunan Astar Biotechnology Ltd.
    Inventors: Zongming Yi, Yi Liu
  • Patent number: 8853139
    Abstract: Provided is a detergent-dispersant for a lubricant having excellent detergency and dispersibility effects. Specifically provided are: a detergent-dispersant including a heterocyclic compound having a heterocyclic skeleton derived from a compound selected from the group consisting of pyridines, pyrroles, pyrimidines, pyrazoles, pyridazines, imidazoles, pyrazines, triazines, triazoles, tetrazoles, oxazoles, oxadiazoles, thiazoles, thiadiazoles, furans, dioxanes, pyrans, and thiophenes; and an additive composition for a lubricant and a lubricant composition, each containing the detergent-dispersant.
    Type: Grant
    Filed: October 19, 2012
    Date of Patent: October 7, 2014
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Junya Iwasaki, Izumi Terada, Hiroaki Koshima
  • Patent number: 8846922
    Abstract: The present invention relates to functionalized fluoroalkylfluorophosphate salts, in particular as ionic liquids, to the preparation thereof and to the use thereof.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: September 30, 2014
    Assignee: Merck Patent GmbH
    Inventors: Berthold Theo Hoge, Anne Julia Bader, Nikolai Mykola Ignatyev, Michael Schulte, Wolfgang Hierse, Waldemar Wiebe, Helge Willner
  • Patent number: 8841299
    Abstract: There are provided compounds of the formula wherein R1 and R2 are as described herein. The compounds are useful as anticancer agents.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: September 23, 2014
    Assignee: Genentech, Inc.
    Inventors: Johannes Hermann, Ann Catherine Petersen, Jutta Wanner, Lin Yi
  • Patent number: 8835650
    Abstract: The present disclosure relates to therapeutic compositions comprising substituted imidazoliums having multiple acidic groups. The compounds may be used to treat diseases or conditions such as those associated with bone, cancer, or pain. Compositions, dosage forms, methods of treating diseases or conditions, methods of preparation, and other related embodiments related to the substituted imidazoliums are also described herein.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: September 16, 2014
    Assignee: Antecip Bioventures II LLC
    Inventor: Herriot Tabuteau