The Hetero Ring Contains -o-c(=x)-o- As Part Of Its Structure, Wherein X Is Chalcogen (e.g., Cyclic Carbonates, Etc.) Patents (Class 549/228)
  • Patent number: 11034664
    Abstract: Techniques regarding the synthesis of cyclic carbonate monomers are provided. For example, one or more embodiments described herein can comprise a method, which can include cyclizing a functionalized diol monomer with N,N?-carbonyldiimidazole, wherein the cyclizing produces a cyclic carbonate monomer and an imidazole carbamate. The method can also include activating the imidazole carbamate with an acid, wherein the activating promotes cyclization of the imidazole carbamate into the cyclic carbonate monomer.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: June 15, 2021
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Nathaniel H. Park, James L. Hedrick, Victoria A Piunova, Pedro Arrechea, Tim Erdmann
  • Patent number: 10266638
    Abstract: 1) Specific polyurethane prepolymer (PP2) comprising at least two terminal (2-oxo-1,3-dioxolan-4-yl)methyl carbamate groups of low viscosity, its preparation process and its use in the manufacture of an adhesive composition. 2) Multicomponent system comprising, as first component (A), a composition comprising at least one such polyurethane prepolymer and, as second component (B), a composition comprising at least one curing agent having at least two primary amine (—NH2) groups (B1). 3) Process for assembling materials employing the polyurethane prepolymer (PP2) according to the invention.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: April 23, 2019
    Assignee: BOSTIK SA
    Inventors: Guillaume Michaud, Marjorie Pereira, Frederic Simon
  • Patent number: 10059789
    Abstract: A carbamate-functional material is prepared by reacting a carbamate compound with a hydroxy-functional material using titanium (IV) alkoxide as catalyst.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: August 28, 2018
    Assignee: BASF Coatings GmbH
    Inventor: Abhijit Jadhav
  • Patent number: 9150534
    Abstract: Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition.
    Type: Grant
    Filed: February 28, 2013
    Date of Patent: October 6, 2015
    Assignees: Northwestern University, Albert Einstein College of Medicine of Yeshiva University
    Inventors: Richard B. Silverman, Mizuki Watanabe, Soosung Kang, Thomas S. Leyh
  • Publication number: 20150044264
    Abstract: Alkyl and/or alkenyl glycerol carbamate prepared by reacting a carbonate selected from the group consisting of glycerol carbonate, diglycerol carbonate, polyglycerol carbonate and mixtures thereof, with an amine of the general formula (I): HNR1R2??(I) wherein R1 represents a hydrogen atom or a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 1 to 22 carbon atoms and R2 represents a hydrocarbon group selected from the group consisting of alkyl groups and alkenyl groups having from 4 to 22 carbon atoms, and cyclic alkyl groups having 5 or 6 carbon atoms, are described along with methods for their use as pearlizing agents in surface-active preparations.
    Type: Application
    Filed: August 4, 2014
    Publication date: February 12, 2015
    Inventors: Bin Gu, Brajesh Jha, Sithamalli Chandramouli, Jie Yang
  • Patent number: 8940855
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Grant
    Filed: April 9, 2013
    Date of Patent: January 27, 2015
    Assignee: International Business Machines Corporation
    Inventors: James L. Hedrick, Alshakim Nelson, Daniel P. Sanders
  • Patent number: 8921580
    Abstract: Described herein are inventive methods for synthesis of cyclic carbonates from CO2 and epoxide. In some embodiments, the methods are carried out in the presence of a catalyst comprising an electrophilic halogen. In some embodiments, the methods are carried out in a flow reactor.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 30, 2014
    Assignee: Massachusetts Institute of Technology
    Inventors: Trevor Alan Hatton, Timothy F. Jamison, Jennifer Aiden Kozak, Fritz Simeon, Jie Wu
  • Publication number: 20140249268
    Abstract: The present invention relates to a method for making a polymer wherein during ring opening polymerisation is incorporated into the polymer chain at least one cyclic (alkyl) carbonate monomer having the formula (1) wherein Y is optional and represents the residue of a sulfhydryl reacted group, X represents a functional group reactive with a sulfhydryl group, L=—[CH2]n with n=0-10, or L=?[CH2]p-S—S—[CH2]q with p and q are 0-5 or L=-[PEG]- with PEG is a group that comprises a —[CH2CH2O]m-group with m=1-200, and R2 is hydrogen, methyl or ethyl. Optionally a cyclic (alkyl) acryloyl carbonate, or other additional monomer A may be used as comonomer. The polymer may be formed into a polymer article, such as a polymer film, such as a coating and modified and/or cross linked, to a polymer or polymer article obtainable, and to a biodevice, their use, and to the cyclic (alkyl)carbonates.
    Type: Application
    Filed: July 4, 2011
    Publication date: September 4, 2014
    Applicant: SSENS B.V.
    Inventors: Zhiyuan Zhong, Fenghua Meng, Rong Wang, Jan Feijen
  • Publication number: 20140243404
    Abstract: This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
    Type: Application
    Filed: September 13, 2011
    Publication date: August 28, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Scott Alan Snyder, Daniel S. Treitler, Alexandria P. Brucks, Andreas Gollner, Maria I. Chiriac, Nathan E. Wright, Jason J. Pflueger, Steven P. Breazzano
  • Publication number: 20140235875
    Abstract: Linear or cyclic carbonates as potential monomers for isocyanate-free polyurethanes and polycarbonates were prepared from polyols and dialkyl carbonates or diphenyl carbonates. This invention was developed to produce linear or cyclic carbonates with or without using catalysts. Polyol compounds were reacted with carbonates such as dimethyl carbonate and diethyl carbonate to produce the corresponding linear and/or cyclic carbonate.
    Type: Application
    Filed: May 14, 2012
    Publication date: August 21, 2014
    Inventors: Rajni Hatti-Kaul, Sang-Hyun Pyo
  • Patent number: 8779166
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: July 15, 2014
    Assignee: International Business Machines Corporation
    Inventors: James Lupton Hedrick, Alshakim Nelson, Daniel Paul Sanders
  • Patent number: 8754208
    Abstract: A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl)carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: June 17, 2014
    Assignee: International Business Machines Corporation
    Inventors: James L. Hedrick, Alshakim Nelson, Daniel P. Sanders
  • Patent number: 8703197
    Abstract: A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n? greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): wherein (n?+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L? is a divalent radical comprising 3 to 30 carbons, and q/(n?+q)×100% equals about 9% to about 47%.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: April 22, 2014
    Assignees: International Business Machines Corporation, Agency for Science, Technology and Research
    Inventors: Wei Cheng, Daniel J. Coady, Amanda C. Engler, James L. Hedrick, Pei Yun Teo, Chuan Yang, Yi Yan Yang
  • Publication number: 20140058058
    Abstract: The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with well-defined functionalities, e.g., polycarbonates and poly(ester-carbonates), compositions thereof, and methods for making and using the same. The invention also provides cytocompatible poly(ethylene glycol)-co-polycarobonate hydrogels (e.g., crosslinked by copper-free, strain-promoted “click” chemistry).
    Type: Application
    Filed: February 24, 2012
    Publication date: February 27, 2014
    Applicant: University of Massachusetts Medical School
    Inventors: Jie Song, Jianwen Xu
  • Patent number: 8642787
    Abstract: A composition comprises a surface modified nanoparticle comprising a core comprising a material selected from the group consisting of organic materials, organometallic materials, inorganic materials, metals, metal oxides, and combinations thereof; and a surface branch covalently linked to the core having the general formula (3):
    Type: Grant
    Filed: June 5, 2012
    Date of Patent: February 4, 2014
    Assignee: International Business Machines Corporation
    Inventors: Kazuki Fukushima, James Lupton Hedrick, Alshakim Nelson, Daniel Paul Sanders
  • Patent number: 8629231
    Abstract: An oligomer is made by capping a uretdione compound of structure with a compound (II) having an active hydrogen and a carbamate or cyclic carbonate group under conditions in which the isocyanate groups but not the uretdione group react. The product (III) is either reacted with a reactant having at least two active hydrogens under reaction conditions that cleave the uretdione ring, after which any cyclic carbonate groups may be converted to carbamate groups, or a product (III) having cyclic carbonate groups is reacted with ammonia or primary amine to provide uretdione with a hydroxy carbamate group that is then self-condensed under uretdione ring-opening conditions. A curable coating composition comprises the oligomer; a coated article is prepared by applying a layer of the curable coating composition and curing the applied layer.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: January 14, 2014
    Assignee: BASF Coatings GmbH
    Inventors: Nicholas Caiozzo, Walter H Ohrbom, David C Cranfill
  • Publication number: 20130274485
    Abstract: A method of manufacturing cyclic carbonate comprises a step of “preparation,” by preparing an ionic liquid polymer; and a step of “cyclization,” by feeding carbon dioxide and epoxide into a reactor containing the ionic liquid polymer to conduct a cyclization of the carbon dioxide and the epoxide in a batch or continuous reaction manner under the catalysis of the ionic liquid polymer, and finally to produce cyclic carbonate.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 17, 2013
    Inventor: Shiey-Shiun HORNG
  • Patent number: 8541605
    Abstract: The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N?-disuccinimidyl derivative, resulted in the formation of, isolatable, substituted cyclic [1,3]-dioxan-2-one and [1,3]-dioxan-2-thione compounds. These isolatable cyclic substituted compounds and derivatives thereof may be used for various applications, such as in vaccination.
    Type: Grant
    Filed: May 11, 2008
    Date of Patent: September 24, 2013
    Assignees: Siolab Ltd., Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
    Inventors: Aaron Garzon, Jean Hildesheim
  • Publication number: 20130245284
    Abstract: Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition.
    Type: Application
    Filed: February 28, 2013
    Publication date: September 19, 2013
    Inventors: Richard B. Silverman, Mizuki Watanabe, Soosung Kang
  • Publication number: 20130237701
    Abstract: A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl)carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.
    Type: Application
    Filed: April 24, 2013
    Publication date: September 12, 2013
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: INTERNATIONAL BUSINESS MACHINES CORPORATION
  • Patent number: 8476428
    Abstract: A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl)carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.
    Type: Grant
    Filed: April 19, 2012
    Date of Patent: July 2, 2013
    Assignee: International Business Machines Corporation
    Inventors: James Lupton Hedrick, Alshakim Nelson, Daniel Paul Sanders
  • Patent number: 8461290
    Abstract: This invention relates to the synthesis of polycarbonates prepared from carbonate monomers derived from the biomass in the presence of a system comprising an organometallic transfer agent and alcohol. It also relates to the polymers resulting from these cyclic compounds.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: June 11, 2013
    Assignees: Total Petrochemicals Research Feluy, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean-François Carpentier, Sophie Guillaume, Marion Helou, Yann Sarazin, Olivier Miserque
  • Patent number: 8450505
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: May 28, 2013
    Assignee: International Business Machines Corporation
    Inventor: James Lupton Hedrick
  • Patent number: 8450504
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: May 28, 2013
    Assignee: International Business Machines Corporation
    Inventors: James Lupton Hedrick, Alshakim Nelson, Daniel Paul Sanders
  • Patent number: 8410290
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: April 2, 2013
    Assignees: International Business Machines Corporation, Central Glass Co., Ltd.
    Inventors: Masaki Fujiwara, James Lupton Hedrick, Daniel Paul Sanders, Manabu Yasumoto
  • Patent number: 8389746
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Grant
    Filed: June 8, 2012
    Date of Patent: March 5, 2013
    Assignees: International Business Machines Corporation, Central Glass Co., Ltd.
    Inventors: Masaki Fujiwara, James Lupton Hedrick, Daniel Paul Sanders, Manabu Yasumoto
  • Publication number: 20130035497
    Abstract: A method of manufacturing cyclic carbonate with carbon dioxide including the steps of placing solid catalyst in a reaction tube, vaporizing epoxide molecules within a buffer tank to obtain an epoxide vapor, and injecting carbon dioxide into the buffer tank. The carbon dioxide mixes with the epoxide vapor in the buffer tank to obtain an air mixture. The air mixture is then conducted into the reaction tube, where catalysis by the solid catalyst generates cyclic carbonate.
    Type: Application
    Filed: August 5, 2011
    Publication date: February 7, 2013
    Inventor: Shiey-Shiun HORNG
  • Patent number: 8349502
    Abstract: Disclosed is an electrolyte comprising a compound having both a sulfonate group and a cyclic carbonate group. The electrolyte forms a more stable and dense SEI layer on the surface of an anode, and thus improves the capacity maintenance characteristics and lifespan characteristics of a battery. Also, disclosed is a compound represented by the following Formula 1, and a method for preparing the same by reacting 4-(hydroxyalkyl)-1,3-dioxolan-2-one with a sulfonyl halide compound: wherein each of R1 and R2 independently represents a C1˜C6 alkylene group optionally containing a C1˜C6 alkyl group or C2˜C6 alkenyl group introduced thereto; R3 is selected from the group consisting of a hydrogen atom, C1˜C20 alkyl group, C3˜C8 cyclic alkyl group, C2˜C6 alkenyl group, halo-substituted alkyl group, phenyl group and benzyl group.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: January 8, 2013
    Assignee: LG Chem, Ltd.
    Inventors: Jeong Hwan Koh, Yong Joon Ha, Jin Hyun Park, Chul Haeng Lee, Young Min Lim, Jeong Ae Ahn, Dmitry Pogozhev
  • Publication number: 20120294845
    Abstract: The invention relates to a method for making a polymer wherein during the polymerisation is incorporated in the polymer chain by ring opening polymerisation a cyclic (alkyl)acryloyl carbonate having the formula (4): wherein R1 and R2 each independently are hydrogen, methyl or ethyl. Preferable the polymer is an (alkyl)acryloyl polycarbonate such that at least one first monomer a cyclic (alkyl)acryloyl carbonate having the formula (4). The (alkyl)acryloyl polyester may be modified and used in biodevices.
    Type: Application
    Filed: December 4, 2009
    Publication date: November 22, 2012
    Applicant: Ssens B.V.
    Inventors: Wei Chen, Fenghua Meng, Rong Wang, Ru Cheng, Zhiyuan Zhong
  • Publication number: 20120252983
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Application
    Filed: June 8, 2012
    Publication date: October 4, 2012
    Applicants: CENTRAL GLASS CO., LTD., INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Masaki Fujiwara, James L. Hedrick, Daniel P. Sanders, Manabu Yasumoto
  • Patent number: 8241533
    Abstract: This invention publishes new usages of kinds of carbonic ester compounds. The new usage described in this invention is related to the application of carbonic ester compounds in the preparation of solvents for chemiluminescent systems. This invention also provides luminescent compositions, luminescent liquids and oxidized liquids that contain carbonic ester compounds. Chemiluminescent compositions containing carbonic ester compounds can decrease reaction pressure effectively, facilitate reaction balance heading to luminescence reaction, generate larger luminescent output without adding catalyst, decrease the dosage of catalyst or not need adding catalyst, decrease influences of over-high output at the reaction start caused by catalyst on whole luminescent time, and ensure stable light output from luminescent compositions. Carbonic ester compounds, especially long carbon chain carbonic ester, have the characters of non-toxic and high flash point, and have suitable solubility on ordinary bis oxalate ester.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: August 14, 2012
    Inventor: Chaoyang Jin
  • Publication number: 20120202993
    Abstract: A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl)carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.
    Type: Application
    Filed: April 19, 2012
    Publication date: August 9, 2012
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James Lupton Hedrick, Alshakim Nelson, Daniel Paul Sanders
  • Publication number: 20120178925
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 12, 2012
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James L. Hedrick, Alshakim Nelson, Daniel P. Sanders
  • Publication number: 20120172603
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 5, 2012
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventor: James L. Hedrick
  • Publication number: 20120172602
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 5, 2012
    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: James L. Hedrick, Alshakim Nelson, Daniel P. Sanders
  • Patent number: 8178700
    Abstract: A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl) carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: May 15, 2012
    Assignee: International Business Machines Corporation
    Inventors: James L. Hedrick, Alshakim Nelson, Daniel P. Sanders
  • Publication number: 20110269917
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Application
    Filed: April 30, 2010
    Publication date: November 3, 2011
    Applicants: CENTRAL GLASS CO., LTD., INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Masaki Fujiwara, James L. Hedrick, Daniel P. Sanders, Manabu Yasumoto
  • Publication number: 20110201828
    Abstract: Process for the preparation of cyclic carbonates by reacting a polyhydric alcohol with a dialkyl carbonate in the presence of a heterogeneous catalyst, wherein the heterogeneous catalyst is a basic mixed oxide or a basic oxide applied to a support.
    Type: Application
    Filed: October 12, 2009
    Publication date: August 18, 2011
    Applicant: BASF SE
    Inventors: Roman Prochazka, Veronika Wloka
  • Patent number: 7939621
    Abstract: A cyclic carbonate monomer, including: wherein R1, R2, and R3 are independently selected from the group consisting of H, linear or branched, substituted or unsubstituted alkyl; R10 is a connecting group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; R4 is an optional bridging group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; Z is selected from the group consisting of O, NH, NR, and S; G is a guanidine group; and P is a protecting group. The cylic carbonate monomer can be reacted with an initiator including a drug, drug candidate, probe or other molecule of interest to form an oligomer with the molecule of interest attached to one end of a carbonate backbone and guanidine groups attached to the carbonate backbone.
    Type: Grant
    Filed: April 30, 2009
    Date of Patent: May 10, 2011
    Assignees: International Business Machines Corporation, Stanford University
    Inventors: Christina Cooley, James Lupton Hedrick, Matthew Kiesewetter, Fredrik Nederberg, Brian Trantow, Robert Waymouth, Paul Wender
  • Patent number: 7902359
    Abstract: This invention relates to a compound of the following formula: wherein R1, R2, R3, G, and Z are defined herein. It also relates to is methods of treating autoimmune disease, cancer, and atherosclerosis with such a compound.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: March 8, 2011
    Assignee: Hutchison MediPharma Enterprises Limited
    Inventors: Tao Wang, Weihan Zhang, Xiaoqiang Yan, Weiguo Su, Jifeng Duan, Yu Cai
  • Publication number: 20100305281
    Abstract: A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl ester group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl ester group. Using a suitable nucleophile, the pendant pentafluorophenyl ester group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.
    Type: Application
    Filed: April 30, 2010
    Publication date: December 2, 2010
    Applicants: INTERNATIONAL BUSINESS MACHINES CORPORATION, CENTRAL GLASS CO., LTD.
    Inventors: Masaki Fujiwara, James L. Hedrick, Alshakim Nelson, Daniel P. Sanders, Yoshiharu Terui, Manabu Yasumoto
  • Publication number: 20100305333
    Abstract: The present disclosure provides processes for the preparation of lipid conjugated cyclic carbonate derivatives. More specifically, the present disclosure is based on the finding that reacting lipids, such as, ceramides, with N,N?-disuccinimidyl derivative, resulted in the formation of, isolatable, substituted cyclic [1,3]-dioxan-2-one and [1,3]-dioxan-2-thione compounds. These isolatable cyclic substituted compounds and derivatives thereof may be used for various applications, such as in vaccination.
    Type: Application
    Filed: May 11, 2008
    Publication date: December 2, 2010
    Applicants: BIOLAB LTD., NASVAX LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Aaron Garzon, Jean Hildesheim
  • Publication number: 20100280242
    Abstract: A method of preparing a cyclic monomer, comprising: forming a first mixture comprising a precursor compound, bis(pentafluorophenyl) carbonate, and a catalyst; wherein the precursor compound has a structure comprising a) two or more carbons, and b) two functional groups selected from the group consisting of primary amine, secondary amine, thiol group, hydroxyl group, and combinations thereof; and agitating the first mixture at a temperature effective to form a second mixture comprising the cyclic monomer, the cyclic monomer selected from the group consisting of a cyclic carbonate, a cyclic carbamate, a cyclic urea, a cyclic thiocarbonate, a cyclic thiocarbamate, and a cyclic dithiocarbonate.
    Type: Application
    Filed: May 4, 2009
    Publication date: November 4, 2010
    Applicant: International Business Machines Corporation
    Inventors: James L. Hedrick, Alshakim Nelson, Daniel P. Sanders
  • Publication number: 20100280219
    Abstract: A cyclic carbonate monomer, including: wherein R1, R2, and R3 are independently selected from the group consisting of H, linear or branched, substituted or unsubstituted alkyl; R10 is a connecting group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; R4 is an optional bridging group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; Z is selected from the group consisting of O, NH, NR, and S; G is a guanidine group; and P is a protecting group. The cylic carbonate monomer can be reacted with an initiator including a drug, drug candidate, probe or other molecule of interest to form an oligomer with the molecule of interest attached to one end of a carbonate backbone and guanidine groups attached to the carbonate backbone.
    Type: Application
    Filed: April 30, 2009
    Publication date: November 4, 2010
    Inventors: Christina Cooley, James L. Hedrick, Matthew Kiesewetter, Fredrik Nederberg, Brian Trantow, Robert Waymouth, Paul Wender
  • Patent number: 7825265
    Abstract: Disclosed herein are novel di-aromatic compounds and methods for using various di-aromatic compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: November 2, 2010
    Assignee: ACADIA Pharmaceuticals Inc.
    Inventors: Roger Olsson, Lene Hyldtoft, Fabrice Piu, Magnus Gustafsson, Vladimir Sherbukhin, Birgitte Winther Lund
  • Publication number: 20100240912
    Abstract: The present invention is to provide a production process capable of selectively producing various kinds of fluorine-containing carbonate compounds without any inhibition in high yields without using phosgene and without producing hydrogen chloride as a by-product. The present invention relates to a process for producing a fluorine-containing compound having a carbonate bond by reacting a compound (1) with a fluorine-containing compound having an OH group. In the formula (1) shown below, X1 to X6 each represents a hydrogen atom or a halogen atom, at least one of X1 to X3 is a halogen atom, and at least one of X4 to X6 is a halogen atom.
    Type: Application
    Filed: June 2, 2010
    Publication date: September 23, 2010
    Inventors: Hidekazu OKAMOTO, Kouhei Tajima, Takashi Okazoe
  • Patent number: 7790908
    Abstract: The present invention relates to a process for preparing highly pure glyceryl carbonate by transesterifying dialkyl carbonates or cyclic carbonates in the presence of a basic catalyst.
    Type: Grant
    Filed: October 11, 2006
    Date of Patent: September 7, 2010
    Assignee: Evonik Roehm GmbH
    Inventors: Bardo Schmitt, Joachim Knebel, Maik Caspari
  • Publication number: 20100035865
    Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I), as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I).
    Type: Application
    Filed: March 26, 2008
    Publication date: February 11, 2010
    Inventors: Kimberly Gail Estep, Anton F.J. Fliri, Christopher J. O'Donnell
  • Patent number: 7652122
    Abstract: A method for producing an aromatic carbonate, comprising: (1) performing a reaction between an organometal compound and carbon dioxide to obtain a reaction mixture containing a dialkyl carbonate formed by the reaction, (2) separating the dialkyl carbonate from the reaction mixture to obtain a residual liquid, (3) reacting the residual liquid with an alcohol to form at least one organometal compound and form water and removing the water from the organometal compound, and (4) reacting the dialkyl carbonate separated in step (2) with an aromatic hydroxy compound to obtain an aromatic carbonate.
    Type: Grant
    Filed: June 25, 2004
    Date of Patent: January 26, 2010
    Assignee: Asahi Kasei Chemicals Corporation
    Inventors: Nobuhisa Miyake, Tomonari Watanabe, Kazuhiro Onishi, Akihiro Sato
  • Patent number: 7635742
    Abstract: Modified stable polyisocyanates are described having at least one isocyanate function modified by a group having cross-linking functionality.
    Type: Grant
    Filed: June 30, 2003
    Date of Patent: December 22, 2009
    Assignee: Rhodia Chimie
    Inventor: Jean-Marie Bernard