Plural Ring Oxygens In The Lactone Ring Patents (Class 549/296)
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Patent number: 11447446Abstract: The invention relates to a use of a fluorination gas, and the elemental fluorine (F2) is present in a high concentration, for example, in a concentration of elemental fluorine (F2), especially of equal to much higher than 15 or even 20% by volume, and to a process for the manufacture of a fluorinated compound by direct fluorination employing a fluorination gas, wherein the elemental fluorine (F2) is present in a high concentration. The process of the invention is directed to the manufacture of a fluorinated compound, for the exception of fluorinated benzene, by direct fluorination. Especially the invention is of interest in the preparation of fluorinated organic compounds, final products and as well intermediates, for usage in agro-, pharma-, electronics-, catalyst, solvent and other functional chemical applications. The fluorination process of the invention may be performed batch-wise or in a continuous manner.Type: GrantFiled: June 20, 2020Date of Patent: September 20, 2022Inventors: Changyue Zhou, Hongjun Du, Wenting Wu
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Patent number: 11292780Abstract: The present invention relates to a process for preparing cyclic carbonates of formula Ia or Ib or mixtures thereof (Ia) (Ib) comprising the process step: a) reacting a propargylic alcohol of formula II (II) with carbon dioxide in the presence of at least one transition metal catalyst TMC1, which comprises a transition metal selected from metals of groups 10, 11 and 12 of the periodic table of the elements according to IUPAC and at least one bulky ligand.Type: GrantFiled: August 14, 2018Date of Patent: April 5, 2022Assignee: BASF SEInventors: Bilguun Bayarmagnai, Thomas Schaub, Verena Mormul, Peter Rudolf
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Patent number: 9127018Abstract: The present invention relates to solid forms of 13-(N-Boc-?-isobutylserinyl)-14-? hydroxybaccatin III 1, 14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.Type: GrantFiled: December 10, 2013Date of Patent: September 8, 2015Assignee: Indena S.p.A.Inventors: Daniele Ciceri, Nicola Sardone, Bruno Gabetta, Maurizio Ricotti
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Publication number: 20140295347Abstract: Acid generator compounds are provided that comprise an oxo-1,3-dioxolane moiety and/or an oxo-1,3-dioxane moiety. The acid generators are particularly useful as a photoresist composition component.Type: ApplicationFiled: March 30, 2013Publication date: October 2, 2014Applicant: Rohm and Haas Electronic Materials, LLCInventor: Rohm and Haas Electronic Materials, LLC
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Patent number: 8703890Abstract: This invention provides a polyfunctional polymer having high stereoregularity, in particular, isotacticity, and provides a production process thereof. The present invention relates to a polymer having, in a molecule, a repeating unit represented by General Formula (2): wherein R1 and R2 are different, and each represents a hydrogen atom, an alkyl group and an aryl group; * represents an asymmetrical carbon, the polymer containing meso diad (m) and racemo diad (r) at a proportion of 60:40 to 100:0 (m:r). The invention also relates to chemical modifications and a production process of the polymer.Type: GrantFiled: January 25, 2010Date of Patent: April 22, 2014Assignee: The University of TokushimaInventor: Hitoshi Tanaka
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Patent number: 8158186Abstract: A chemical compound of the general formula I or II is useful as feed additive: wherein X=O or NR, and R=H, C1-C6-alkyl (optionally branched), C3-C6-cycloalkyl, aryl, or aralkyl, and wherein R1, R2, are identical or different and in each case H, C1-C6-alkyl (optionally branched), C3-C6-cycloalkyl, allyl, aryl, or aralkyl; or R1 and R2 together are an C2- to C6-alkylene group (optionally C1-C6-alkyl substituted).Type: GrantFiled: December 19, 2008Date of Patent: April 17, 2012Assignee: Evonik Degussa GmbHInventors: Christoph Kobler, Philipp Roth, Christoph Weckbecker, Klaus Huthmacher
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Publication number: 20120088160Abstract: The present technology relates to stabilizing additives and electrolytes containing the same for use in electrochemical devices such as lithium ion batteries and capacitors. The stabilizing additives include triazinane triones and bicyclic compounds comprising succinic anhydride, such as compounds of Formulas I and II described herein.Type: ApplicationFiled: October 7, 2010Publication date: April 12, 2012Inventors: Lu Zhang, Zhengcheng Zhang, Khalil Amine
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Publication number: 20110282004Abstract: This invention provides a polyfunctional polymer having high stereoregularity, in particular, isotacticity, and provides a production process thereof. The present invention relates to a polymer having, in a molecule, a repeating unit represented by General Formula (2): wherein R1 and R2 are different, and each represents a hydrogen atom, an alkyl group and an aryl group; * represents an asymmetrical carbon, the polymer containing meso diad (m) and racemo diad (r) at a proportion of 60:40 to 100:0 (m:r). The invention also relates to chemical modifications and a production process of the polymer.Type: ApplicationFiled: January 25, 2010Publication date: November 17, 2011Applicant: The University of TokushimaInventor: Hitoshi Tanaka
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Patent number: 7569576Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.Type: GrantFiled: January 12, 2006Date of Patent: August 4, 2009Assignee: XenoPort, Inc.Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
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Publication number: 20090162474Abstract: A chemical compound of the general formula I or II is useful as feed additive: wherein X=O or NR, and R=H, C1-C6-alkyl (optionally branched), C3-C6-cycloalkyl, aryl, or aralkyl, and wherein R1, R2, are identical or different and in each case H, C1-C6-alkyl (optionally branched), C3-C6-cycloalkyl, allyl, aryl, or aralkyl; or R1 and R2 together are an C2- to C6-alkylene group (optionally C1-C6-alkyl substituted).Type: ApplicationFiled: December 19, 2008Publication date: June 25, 2009Applicant: EVONIK DEGUSSA GmbHInventors: Christoph Kobler, Philipp Roth, Christoph Weckbecker, Klaus Huthmacher
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Patent number: 7507838Abstract: A process for preparing Z-5-carboxymethylene-1,3-dioxolan-4-ones is provided which includes the steps of reacting a bis-ketal or bis-acetal of tartaric acid with a potassium containing base to form the carboxymethylene-1,3-dioxolan-4-one. A process for preparing HIV integrase inhibitors employing the carboxymethylene-1,3-dioxolan-4-one inhibitor is also provided.Type: GrantFiled: August 22, 2005Date of Patent: March 24, 2009Assignee: Bristol-Myers Squibb CompanyInventors: William A. Nugent, Keming Zhu, James H. Simpson, Edward J. Delaney
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Publication number: 20080125483Abstract: The invention provides novel compounds of Formula (I), pharmaceutical compositions and methods of synthesis thereof.Type: ApplicationFiled: November 21, 2007Publication date: May 29, 2008Inventors: Jenn-Tsang Hwang, Chrong-Shiong Hwang, Yow-Lone Chang, Chung-Niang Yao
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Patent number: 7316884Abstract: A 5-methylene-1,3-dioxolan-4-one derivative and a monomer and copolymer thereof and a resist composition containing the polymer or copolymer where the 5-methylene-1,3 -dioxolan-4-one derivative is of formula (1): wherein R1 represents a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms, or a linear or branched alkyl group containing 1 to 6 carbon atoms which has a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms as a substituent; R2 represents a hydrogen atom, or a linear or branched alkyl group containing 1 to 6 carbon atoms; or R1 and R2 represent a bridged cyclic hydrocarbon group containing 4 to 16 carbon atoms together with the carbon atom to which they are bound, provided that the alkyl group and the bridged cyclic hydrocarbon group may have at least one substituent selected from a group consisting of a linear or branched alkyl group containing 1 to 6 carbon atoms which may be optionally substituted, a hydroxy group, a carboxy group, an acyl group containing 2 to 6 carType: GrantFiled: October 22, 2002Date of Patent: January 8, 2008Assignee: Mitsubishi Rayon Co., Ltd.Inventors: Ryuichi Ansai, Yoshihiro Kamon, Tadayuki Fujiwara, Hideaki Kuwano, Atsushi Ootake, Hikaru Momose
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Patent number: 7268238Abstract: The method of producing 4-fluoroethylene carbonate (FEC), in which ethylene carbonate (EC) reacts with a mixture of fluorine and nitrogen gases, includes feeding a mixture gas of fluorine gas and nitrogen gas into a reactor having ethylene carbonate charged therein, so as to react the ethylene carbonate with the mixture gas of the fluorine gas and the nitrogen gas. The mixture gas fed in the reactor is regulated to have a desired bubble size while passing through a gas bubble regulating column, in which a packing for a packed column is packed. In the method, EC directly reacts with F2/N2 mixture gas to produce FEC, thus a purification process is simple and it is possible to produce FEC at high conversion efficiency and selectivity.Type: GrantFiled: March 7, 2005Date of Patent: September 11, 2007Assignee: Ulsan Chemical Co., Ltd.Inventors: Byung Won Woo, Seoung Woo Yoon, Jun Ho Lee, Soon Hong Park, Nak Joon Jang, Hyo Jin Yoon
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Patent number: 7232916Abstract: The invention relates to an improved process for the synthesis of 13-(N-Boc-?-isobutylserinyl)-14-?-hydroxybaccatin III-1,14-carbonate (I), wherein carbonation of the 1,14-hydroxy groups of the baccatin skeleton is carried out with bis(trichloromethylcarbonate and the 7-hydroxy group is protected with a trichloroacetyl group.Type: GrantFiled: May 11, 2006Date of Patent: June 19, 2007Assignee: Indena S.p.A.Inventors: Bruno Gabetta, Daniele Ciceri
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Patent number: 7094805Abstract: This invention provides a total synthesis of Merrillactone and Merrilactone analogues for use as neurotrophic agents in the treatment of neurodegenerative diseases. The invention also provides intermediates for use in the synthesis of Merrilactone and its analogues.Type: GrantFiled: December 13, 2002Date of Patent: August 22, 2006Assignee: The Trustees of Columbia University in the City of New YorkInventors: Samuel J. Danishefsky, Vladimir B. Birman
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Patent number: 7019150Abstract: 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.Type: GrantFiled: August 7, 2003Date of Patent: March 28, 2006Assignee: Florida State UniversityInventors: Robert A. Holton, Suhan Tang, Feng Liang, Carmen Somoza
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Patent number: 6841667Abstract: The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.Type: GrantFiled: July 7, 2003Date of Patent: January 11, 2005Assignee: President and Fellows of Harvard CollegeInventors: Eric N. Jacobsen, Makoto Tokunaga, Jay F. Larrow
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Patent number: 6828347Abstract: This invention provides various biquinone and trimeric quinone derivatives. The invention also provides a method for synthesis of a multi-quinone compound including reacting a hydroxyquinone anion with a first quinone possessing a first directing group at a C-2 of the first quinone and a second directing group at a C-3 of the first quinone and obtaining a biquinone having one of the first and second directing groups at a C-3 of a first quinone monomer and a hydroxyl group at a C-3′ of a second quinone monomer. The biquinone can be further reacted to obtain various biquinone derivatives or with a second hydroxyquinone anion to obtain trimeric quinone derivatives, including trimeric naphthoquinone derivatives. The biquinones and trimeric quinones of this invention demonstrate antiviral activity and can be used to treat viral infections, particularly HIV infections.Type: GrantFiled: November 6, 2002Date of Patent: December 7, 2004Assignee: Illinois Institute of TechnologyInventors: Kenneth William Stagliano, Ashkan Emadi
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Patent number: 6818766Abstract: Bicalutamide and/or its intermediates are made by the use of p-fluorobenzenesulfinic acid salt as a reagent.Type: GrantFiled: October 2, 2002Date of Patent: November 16, 2004Assignee: Synthon BVInventors: Lambertus Thijs, Rolf Keltjens, Gerrit Jan Bouke Ettema
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Patent number: 6803378Abstract: Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC.Type: GrantFiled: September 25, 2002Date of Patent: October 12, 2004Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Walker, Timothy D. Johnson, Nicholas A. Meanwell, Jacque Banville
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Patent number: 6800766Abstract: The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.Type: GrantFiled: July 26, 2002Date of Patent: October 5, 2004Assignee: President and Fellows of Harvard CollegeInventors: Eric N. Jacobsen, Makoto Tokunaga, Jay F. Larrow
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Patent number: 6777440Abstract: The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the following formula, or a tautomer of said compound, or a pharmaceutically acceptable salt, solvate or prodrug thereof: wherein R1, R2 and B1 are as defined herein.Type: GrantFiled: December 6, 2002Date of Patent: August 17, 2004Assignee: Bristol-Myers Squibb CompanyInventors: Michael A. Walker, Jacques Banville, Roger Remillard, Serge Plamondon
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Patent number: 6737534Abstract: A process for the preparation of the compound 13-(N-Boc-&bgr;-isobutylisoserinyl)-14&bgr;-hydroxybaccatine III 1,14-carbonate.Type: GrantFiled: May 27, 2003Date of Patent: May 18, 2004Assignee: Indena S.p.A.Inventors: Alessandro Pontiroli, Ezio Bombardelli
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Patent number: 6720302Abstract: (6R)-4,5,6,7-Tetrahydro 3,6-dimethyl-3H-benzo[b]furan-2-one is a compound of use in perfumery and the field of flavorings. The compound can be used to impart a minty, slightly vanilla-scented odor, and its flavor imparts sweetness and roundness to the compositions to which it is added.Type: GrantFiled: January 10, 2002Date of Patent: April 13, 2004Assignee: Firmenich SAInventors: Eric Frerot, Alain Bagnoud
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Publication number: 20030176495Abstract: The present invention relates to the inhibition of HIV integrase, and to the treatment of AIDS or ARC by administering compounds of the following formula, or a tautomer of said compound, or a pharmaceutically acceptable salt, solvate or prodrug thereof: 1Type: ApplicationFiled: December 6, 2002Publication date: September 18, 2003Inventors: Michael A. Walker, Jacques Banville, Roger Remillard, Serge Plamondon
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Patent number: 6476251Abstract: The present invention relates to a novel process for preparing compounds of the formula (I) by reacting compounds of the formula (II) with a base and compounds of the formula (III) in which X, Y, Z, n, G, A, B, R1, R8 and Hal are each as defined above.Type: GrantFiled: March 12, 2001Date of Patent: November 5, 2002Assignees: Bayer Aktiengesellschaft, Bayer CorporationInventor: Volker Falbe
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Patent number: 6350907Abstract: Compounds of formula (I): or pharmaceutically acceptable salts thereof, or solvates of either entity, wherein the substituents have the values described herein, are useful as matrix metalloprotease (MMP) inhibitorsType: GrantFiled: April 11, 2000Date of Patent: February 26, 2002Assignee: Pfizer IncInventors: Michael Jonathan Fray, Roger Peter Dickinson, Kevin Neil Dack
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Patent number: 6307067Abstract: Nucleophilic oxygen species, such as primary alcohols, carboxylates, and water, are added to vinyl epoxides in a highly regioselective and enantioselective manner, providing a convenient route to enantiomerically enriched 1,2-diols and oxygen-containing heterocycles. The reaction employs a chiral Pd(0) complex and a borane or borate as co-catalysts Also described are similar additions of nitrogen nucleophiles, and the addition of carbonates to vinyl epoxides using a chiral Pd(0) catalyst.Type: GrantFiled: September 7, 1999Date of Patent: October 23, 2001Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Ernest John McEachern, Francisco Dean Toste, Barry Martin Trost
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Patent number: 6262278Abstract: The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral catalyst to produce a stereoisomerically- and/or regioisomerically-enriched product. The present invention also relates to hydrolytic kinetic resolutions of racemic and diastereomeric mixtures of epoxides.Type: GrantFiled: August 14, 1998Date of Patent: July 17, 2001Assignee: President and Fellows of Harvard CollegeInventors: Eric N. Jacobsen, Makoto Tokunaga, Jay F. Larrow
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Patent number: 5929232Abstract: The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst to produce a stereoisomerically or regioselectively enriched product.Type: GrantFiled: March 25, 1996Date of Patent: July 27, 1999Assignee: President and Fellows of Harvard CollegeInventors: Eric N. Jacobsen, James L. Leighton, Luis E. Martinez
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Patent number: 5912360Abstract: The present invention relates to intermediates, useful for the preparation of therapeutically active hydroxamic acid derivatives which are inhibitors of metalloproteinases involved in tissue degradation, and are inhibitors of the release of tumour necrosis factor from cells.Type: GrantFiled: October 23, 1997Date of Patent: June 15, 1999Assignee: British Biotech Pharmaceuticals LimitedInventor: Jonathan Philip Dickens
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Patent number: 5559252Abstract: The present invention provides a process for the preparation of compounds of formula (V) below, and analogs thereof, which are useful as intermediates for the synthesis of HIV protease inhibitors, including cyclic ureas.Type: GrantFiled: June 30, 1994Date of Patent: September 24, 1996Assignee: The DuPont Merck Pharmaceutical CompanyInventor: Robert F. Kaltenbach III
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Patent number: 5486625Abstract: Described is a process for preparing chiral compounds of the formula ##STR1## wherein X.sup.1 and X.sup.2 are independently F or Cl, and Y is Cl, Br or I, comprising reacting a triol of the formula ##STR2## wherein X.sup.1 and X.sup.2 are as defined above, with acetone in the presence of a catalyst, then with a halogen selected from Cl.sub.2, Br.sub.2 or I.sub.2, or N-bromosuccinimide or N-iodosuccinimide.Type: GrantFiled: July 8, 1994Date of Patent: January 23, 1996Assignee: Schering CorporationInventors: William Leong, Lyman H. Smith
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Patent number: 5164499Abstract: Nitroaryl carbonyl Formula (IIA) compounds, their nitrodihydroaryl carbonyl Formula (I) intermediates, processes for preparing Formula (II) compounds, and a process for preparing Formula (I) compounds, wherein each process comprises the reaction of a nitroaryl compound with a silane.Type: GrantFiled: January 2, 1990Date of Patent: November 17, 1992Assignee: E. I. Du Pont de Nemours and CompanyInventor: Thaliyil V. Rajanbabu
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Patent number: 5138074Abstract: A continuous catalyzed vapor phase process for the production of dimeric cyclic esters which comprises converting the corresponding alpha-hydroxy-carboxylic acid or ester in the vapor phase over a solid catalyst, such as a silica-alumina, preferably a silica-alumina having a high silica content, in the presence of a carrier of gas.Type: GrantFiled: June 28, 1990Date of Patent: August 11, 1992Assignee: E. I. Du Pont de Nemours and CompanyInventors: Harold E. Bellis, Kamlesh K. Bhatia
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Patent number: 5102906Abstract: Catechol derivatives which relate to the production of nerve growth factor in particular tissues of brain are disclosed.Methods for the synthesis, data on the physiological activity, and data on the toxicity of these derivatives as well as examples of preparation for their administration are also disclosed.The disclosed derivatives provide preventive and remedial effect for regressive disorders in the central nervous system including senile dementia of Alzheimer type.Type: GrantFiled: October 31, 1990Date of Patent: April 7, 1992Assignee: Mitsui Toatsu Chemicals, IncorporatedInventors: Shigenobu Nakayama, Fumiaki Ikeda
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Patent number: 5049699Abstract: Disclosed are 1- and 2-mono esters of citric acid and methods for preparing them in the pure form. These novel compounds are useful as surfactants.Type: GrantFiled: January 22, 1990Date of Patent: September 17, 1991Assignee: Haarmanns' Reimer CorpInventor: Michael P. Kotick
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Patent number: 5004832Abstract: Compounds are described of formula ##STR1## in which: Ar represents an aryl, possibly substituted;R represents a C.sub.1 -C.sub.4 alkyl;R' represents a hydroxyl, an alkoxy, an amino group possibly mono or di-alkyl substituted, or an O.sup.-- M.sup.+ group where M.sup.+ represents the cation of an alkaline metal;X represents a hydrogen, chlorine, bromine or iodine atom, a hydroxyl, or an acyloxy, alkylsulphonyloxy or arylsulphonyloxy group.The compounds of formula I can be easily transformed into alpha-arylalkanoic acids of formula ##STR2## in which Ar and R have the aforesaid meanings.Type: GrantFiled: February 6, 1989Date of Patent: April 2, 1991Assignee: Zambon S.p.A.Inventors: Graziano Castaldi, Claudio Giordano
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Patent number: 4845243Abstract: Compounds of formula ##STR1## (wherein Ar, R, R.sub.1 and X have the meanings reported in the description) are useful intermediates for the preparation of a variety of organic compounds, also optically active, like alpha-haloketones, alpha-hydroxyketones or ketals, alpha-arylalkanoic acids.Type: GrantFiled: December 18, 1987Date of Patent: July 4, 1989Assignee: Zambon S.p.A.Inventors: Claudio Giordano, Graziano Castaldi
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Patent number: 4824970Abstract: Compounds are described of formula ##STR1## in which: Ar represents a aryl, possibly substituted;R represents a C.sub.1 -C.sub.4 alkyl;R' represents a hydroxyl, an alkoxy, an amino group possibly mono or di-alkyl substituted, or an O-M+ group where M+ represents the cation of an alkaline metal;X represents a hydrogen, chlorine, bromine or iodine atom, a hydroxyl, or an acyloxy, alkylsulphonyloxy or arylsulphonyloxy group.The compounds of formula I can be easily transformed into alphaarylalkanoic acids of formula ##STR2## in which Ar and R have the aforesaid meanings.Type: GrantFiled: July 31, 1986Date of Patent: April 25, 1989Assignee: ZAMBON SpaInventors: Graziano Castaldi, Claudio Giordano
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Patent number: 4447625Abstract: The invention relates to novel 4-(1H-azolylmethyl)-1,3-dioxolan-5-one derivatives of the formula I ##STR1## and to the production and use of these compounds. In formula I, R.sub.1 and R.sub.2 are unsubstituted or substituted alkyl or phenyl, or together form a 3- to 7-membered carbocyclic ring which is unsubstituted or substituted, A is an unsubstituted or substituted phenyl radical, and X is --CH.dbd. or --N.dbd.. The compounds of the formula I can be used in the form of appropriate compositions for regulating plant growth and/or for controlling and/or protecting plants from attack by phytopathogenic microorganisms.Type: GrantFiled: September 23, 1982Date of Patent: May 8, 1984Assignee: Ciba-Geigy CorporationInventor: Walter Kunz
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Patent number: 4384879Abstract: The invention relates to novel 4-(1H-azolylmethyl)-1,3-dioxolan-5-one derivatives of the formula I ##STR1## and to the production and use of these compounds. In formula I, R.sub.1 and R.sub.2 are unsubstituted or substituted alkyl or phenyl, or together form a 3- to 7-membered carbocyclic ring which is unsubstituted or substituted, A is an unsubstituted or substituted phenyl radical, and X is --CH.dbd. or --N.dbd.. The compounds of the formula I can be used in the form of appropriate compositions for regulating plant growth and/or for controlling and/or protecting plants from attack by phytopathogenic microorganisms.Type: GrantFiled: July 6, 1981Date of Patent: May 24, 1983Assignee: Ciba-Geigy CorporationInventor: Walter Kunz
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Patent number: 4348322Abstract: The invention is concerned with novel dioxolane derivatives of the formula: ##STR1## in which R.sub.a is hydrogen or (1-4C)alkyl and R.sub.b is (1-4C)alkyl or phenyl optionally bearing a halogeno substituent; their production; and their use for the manufacture of certain known anti-arthritic acids of the formula: ##STR2## and, in particular, those acids in which R.sub.a =R.sub.b =methyl or R.sub.a =ethyl and R.sub.b =phenyl, by a novel reduction process. The preferred reduction procedures involve the use of an alkali metal borohydride or cyanoborohydride in the presence of a noble metal catalyst, or the use of an .alpha.-branched alkyl or cycloalkyl Grignard agent.The use of the derivatives of formula I avoids the need for potentially toxic reagents and reactive intermediates in the previously known processes for the production of the acids of formula V.Type: GrantFiled: March 11, 1981Date of Patent: September 7, 1982Assignee: Imperial Chemical Industries LimitedInventors: Philip N. Edwards, David M. G. Martin