The Lactone Ring Is Five-membered Patents (Class 549/295)
  • Patent number: 10780428
    Abstract: A process for producing a metal carbonate-containing shaped catalyst body for the hydrogenation of an organic compound having one or more carbonyl group, in which a) a metal carbonate composition which contains, based on the total weight of the metal carbonate composition, from 70 to 94.5% by weight of a metal carbonate mixture containing two or more than two metal carbonates of two or more than two different metals (M), from 5 to 25% by weight of metallic copper, and from 0.5 to 5% by weight of tableting aid is provided, b) a shaped body is formed from the metal carbonate composition provided in step a), and c) the shaped body obtained in step b) is activated in the presence of hydrogen at a temperature in the range from 150 to 250° C.
    Type: Grant
    Filed: November 9, 2017
    Date of Patent: September 22, 2020
    Assignee: BASF SE
    Inventors: Thomas Heidemann, Barbara Wucher, Thomas Koelker, Michel Pepers, Ulf Brinkmann, Magnus Topphoff, Horst Josten
  • Patent number: 10703705
    Abstract: Control or repellency of bed bugs is accomplished by bringing the bed bugs into contact with at least one of the compounds of the structure (I); wherein R is selected from —OH, —OC(O)R4, —OR6, —(OR6)2, wherein each R6 is independently selected from an alkyl group containing from 1 to 4 carbon atoms and R4 is a branched or straight chain saturated or unsaturated hydrocarbyl group with zero to two double bonds and from 1 to 15 carbon atoms; X is O or CH2, with the proviso that when X is O R can only be =0; each Z is independently selected from (CH) and (CH2) y is a numeral selected from 1 and 2; R1 is selected from H or a branched or straight chain saturated or unsaturated hydrocarbyl group with zero to two double bonds and from 1 to 15 carbon atoms. R2 is selected from H and a branched or straight chain saturated or unsaturated hydrocarbyl group with zero to three double bonds and from 1 to 15 carbon atoms.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: July 7, 2020
    Assignee: Bedoukian Research, Inc.
    Inventor: Robert H. Bedoukian
  • Patent number: 10662451
    Abstract: The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least one exogenous nucleic acid encoding a 14-BDO and GBL pathway enzyme expressed in a sufficient amount to produce 14-BDO and GBL. The invention additionally provides methods of using such microbial organisms to produce 14-BDO and GBL.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: May 26, 2020
    Assignee: Genomatica, Inc.
    Inventors: Jun Sun, Mark J. Burk, Anthony P. Burgard, Robin E. Osterhout, Wei Niu, John D. Trawick, Robert Haselbeck
  • Patent number: 10502729
    Abstract: The present invention provides a method for diagnosing a disease or disorder selected from the group consisting of insulin resistance, a metabolic disorder, diabetes and pre-diabetes in a subject. The method comprises the step of determining the level of a compound represented by structural formula (VI): or a salt thereof. Compositions and method of making thereof are also described.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: December 10, 2019
    Assignee: Metabolon, Inc.
    Inventors: Luke Miller, Klaus Peter Adam, Michael V. Milburn, Jeffery E. Cobb, Anne M. Evans, Qibo Zhang
  • Patent number: 10227318
    Abstract: Provided is a method for producing ?-valerolactone that is hard to elute metallic components and has high productivity. ?-Valerolactone is synthesized by bringing a levulinic acid compound represented by the formula (1) (where R represents a hydrogen atom, a linear alkyl group of 1 to 6 carbon atoms or a branched alkyl group of 3 to 6 carbon atoms) into contact with hydrogen in the presence of a catalyst in which two or more different kinds of metals of Group VIII to Group X metals in the periodic table are supported on a support.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: March 12, 2019
    Assignee: UBE INDUSTRIES, LTD.
    Inventors: Atsushi Yamada, Yasushi Yamamoto
  • Patent number: 10183923
    Abstract: This disclosure provides a method for preparing a precursor of a single dairy-lactone isomer, methods of preparing a single dairy-lactone isomer, and to the organoleptic uses thereof.
    Type: Grant
    Filed: April 8, 2016
    Date of Patent: January 22, 2019
    Assignees: INSTITUT DES SCIENCES ET INDUSTRIES DU VIVANT ET DE L'ENVIRONNEMENT—AGROPARIS TECH, UNIVERSITY OF NEW ENGLAND, CIRCA GROUP PTY LTD
    Inventors: Florent Allais, Amandine Flourat, Aurélien Peru, Ben Greatrex, Warwick Raverty, Anthony Duncan
  • Patent number: 9975826
    Abstract: Provided is a method for producing an aliphatic alcohol having 8 or more and 22 or less carbon atoms through hydrogenation of a fatty acid or a fatty acid ester using a catalyst, wherein the catalyst carries a catalyst metal on a support, (a) the catalyst contains one or more elements selected from Co and Cu as the catalyst metal, (b) the total pore volume of the catalyst is 0.05 mL/g or more, and (c) the volume of pores with a pore size of 0.1 ?m or more and 500 ?m or less is 50% or more of the total pore volume of the catalyst.
    Type: Grant
    Filed: November 17, 2015
    Date of Patent: May 22, 2018
    Assignee: KAO CORPORATION
    Inventors: Sho Aida, Taichi Homma
  • Patent number: 9206151
    Abstract: The present invention relates to methods of preparing fused ring indeno compounds that involves reacting together a dienophile and a lactone compound, in the presence of a catalyst, and a carboxylic acid anhydride.
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: December 8, 2015
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Massimiliano Tomasulo, Allison Greene, Anil Kumar
  • Publication number: 20150118382
    Abstract: The object of this application is to non-enzymatically improve flavor of a butter oil and fat composition. The present invention can enrich lactones in the oil and fat composition by the following steps of keeping temperature of the oil and fat composition containing between 300 ppm and 1200 ppm of moisture content at the temperature where a solid fat exists in the oil and fat composition, and non-enzymatically producing ?-lactone or ?-lactone from triglyceride containing 4- or 5-hydroxy fatty acid in the oil and fat composition, or adding to the oil and fat composition an additive agent (such as, sucrose) which has an ability to form hydrogen bonds with water molecules, keeping temperature of the oil and fat composition at the temperature between 40 and 60° C., and non-enzymatically producing ?-lactone or ?-lactone from triglyceride containing 4- or 5-hydroxy fatty acid in the oil and fat composition.
    Type: Application
    Filed: January 11, 2013
    Publication date: April 30, 2015
    Inventor: Mitsuya Shimoda
  • Publication number: 20150073156
    Abstract: The present invention relates to a production method of ?-methylene lactone which comprises the following steps: (A) a step of producing an enolate intermediate by making lactone react with alkyl formate under the presence of an alkoxide base; and (B) making the enolate intermediate react with paraformaldehyde. The production method of the present invention is capable of reducing the process time, improving yield, and minimizing the contamination of a reactor.
    Type: Application
    Filed: July 20, 2012
    Publication date: March 12, 2015
    Inventors: Myung Ryul Lee, Sun Dae Kim, In Sik Jeon, Won Gi Lee, Sung Hee Ahn, Sang Hyun Hong
  • Publication number: 20150065339
    Abstract: Catalysts prepared from abundant, cost effective metals, such as cobalt, nickel, chromium, manganese, iron, and copper, and containing one or more neutrally charged ligands (e.g., monodentate, bidentate, and/or polydentate ligands) and methods of making and using thereof are described herein. Exemplary ligands include, but are not limited to, phosphine ligands, nitrogen-based ligands, sulfur-based ligands, and/or arsenic-based ligands. In some embodiments, the catalyst is a cobalt-based catalyst or a nickel-based catalyst. The catalysts described herein are stable and active at neutral pH and in a wide range of buffers that are both weak and strong proton acceptors. While its activity is slightly lower than state of the art cobalt-based water oxidation catalysts under some conditions, it is capable of sustaining electrolysis at high applied potentials without a significant degradation in catalytic current. This enhanced robustness gives it an advantage in industrial and large-scale water electrolysis schemes.
    Type: Application
    Filed: July 2, 2014
    Publication date: March 5, 2015
    Inventors: Aaron J. Bloomfield, Stafford W. Sheehan, Samuel L. Collom, Robert H. Crabtree, Paul T. Anastas
  • Patent number: 8957111
    Abstract: A compound of formula (ascorbate)2Sr:(M+a)x(ascorbate)y, or ascorbate)2Sr:Ca(ascorbate)2, a composition containing the same, a method of making the same and a method of administering the same as a supplement.
    Type: Grant
    Filed: February 11, 2013
    Date of Patent: February 17, 2015
    Assignee: Nutraceutical Corporation
    Inventors: Shayne Morris, Richard Bush
  • Publication number: 20140371417
    Abstract: The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4-hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4-hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms.
    Type: Application
    Filed: April 25, 2014
    Publication date: December 18, 2014
    Applicant: Genomatica, Inc.
    Inventors: Priti PHARKYA, Anthony P. BURGARD, Stephen J. VAN DIEN, Robin E. OSTERHOUT, Mark J. BURK, John D. TRAWICK, Michael P. KUCKINSKAS, Brian STEER
  • Publication number: 20140303420
    Abstract: The invention relates to a process for the production of gamma-valerolactone (GVL) by gas phase hydrogenation of furfural or furfuryl alcohol in the presence of a solid catalyst. The conversion of furfural or furfuryl alcohol to GVL is conducted in one single step.
    Type: Application
    Filed: November 2, 2012
    Publication date: October 9, 2014
    Applicant: Haldor Topsøe A/S
    Inventors: Martin Holmes Spangsberg, Hanne Stummann Zingler, Esben Taarning
  • Publication number: 20140296466
    Abstract: The present invention relates to a method of producing bio-based homoserine lactone and bio-based organic acid through hydrolysis of O-acyl homoserine produced by a microorganism in the presence of an acid catalyst. According to the present invention, O-acyl homoserine produced by a microorganism is used as a raw material for producing 1,4-butanediol, gamma-butyrolactone, tetrahydrofuran and the like, which are industrially highly useful. The O-acyl homoserine produced by a microorganism can substitute conventional petrochemical products, can solve environmental concerns, including the emission of pollutants and the exhaustion of natural resources, and can be continuously renewable so as not to exhaust natural resources.
    Type: Application
    Filed: March 19, 2014
    Publication date: October 2, 2014
    Inventors: Han Won Lee, Young Lyeol Yang, So Young Kim, Yong Uk Shin, Jin Sook Chang, Hye Won Um, Young Hyoung Goh, Sung Hoo Jhon
  • Patent number: 8779168
    Abstract: The present invention relates to lactone compounds represented by the following Formulas I and II, and methods of making such lactone compounds. The present invention also relates to methods of making other materials from such lactone compounds, such as fused ring indenol compounds (e.g., indeno-fused naphthols), and fused ring indenopyran compounds (e.g., indeno-fused naphthopyrans).
    Type: Grant
    Filed: December 7, 2011
    Date of Patent: July 15, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Meng He, Darrin R. Dabideen, Ruisong Xu, Anil Kumar
  • Publication number: 20140100376
    Abstract: ?-Hydroxycarboxylic esters and ?-lactones which are suitable as flavors can be prepared by electrochemical reductive cross-coupling of ?,?-unsaturated esters with carbonyl compounds in an undivided electrolysis cell having a cathode composed of lead, lead alloys, cadmium, cadmium alloys, mercury, steel, glassy carbon or boron-doped diamonds and a basic aqueous electrolyte comprising an electrolyte salt which suppresses the cathodic formation of hydrogen.
    Type: Application
    Filed: October 25, 2013
    Publication date: April 10, 2014
    Applicant: BASF SE
    Inventors: Itamar Michael Malkowsky, Florian Stecker, Simone Lutter, Olivier Abillard, Ralf Pelzer
  • Patent number: 8669377
    Abstract: What is disclosed in the invention is a preparation method of a supercritical Cinnamomum subavenium extract, which is made from the material, the dried stem of C. subavenium. The extract is obtained by extracting C. subavenium which is pulverized as particles with supercritical carbon dioxide fluid. The C. subavenium extract or its active ingredient, subamolide A, can be used to inhibit the growth of human urothelial carcinoma cell lines. In addition, the C. subavenium extract (or subamolide A) is able to synergistically inhibit the growth of human urothelial carcinoma cell lines with cisplatin (CDDP) or gemcitabine (Gem). Therefore, the C. subavenium extract (or subamolide A) can be an anticancer drug alone, or forms a pharmaceutical composition with CDDP (or Gem) to treat with cancers in respect of urinary system.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: March 11, 2014
    Assignee: Kaohsiung Medical University
    Inventors: Jih-Heng Li, A-Mei Huang, Chung-Yi Chen, Pei-Jung Lien, Chiung-Hui Liu
  • Publication number: 20140058021
    Abstract: A composition, which comprises a) an organic material susceptible to oxidative, thermal or light-induced degradation; and b) a compound of formula I (Formula I) (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently from each other H, C1-C8-alkyl, C4-C8-cycloalkyl, phenyl, C1-C4-alkoxy or halogen; n is 1, 2, 3, or 4; and when n is 1 A is —C(=0)-OR?1, —C(=0)-N(R?2)(R?3), —CN, phenyl, which is unsubstituted or substituted by one or more C1-C8-alkyl, C4-C8-alkoxy, C5-C7-cycloalkyl or halogen, —H or —S02-phenyl; when n is 2 A is —C(=0)-O—Z1—O—C(=0)-, —C(=0)-N(R?1)—Z2—N(R?2)—C(=0)- or piperazine-N,N?-biscarbonyl.
    Type: Application
    Filed: April 25, 2012
    Publication date: February 27, 2014
    Applicant: BASF SE
    Inventors: Walter Fischer, Abdel-Ilah Basbas, Kai-Uwe Schoning, Cinzia Tartarini, Werner Holzl, Bruno Rotzinger
  • Patent number: 8637623
    Abstract: Disclosed is a monomer having an electron-withdrawing substituent and a lactone skeleton, represented by Formula (1), wherein Ra represents, e.g., hydrogen or an alkyl group having 1 to 6 carbons; R1 represents, e.g., a halogen or an alkyl or haloalkyl group having 1 to 6 carbons; “A” represents an alkylene group having 1 to 6 carbons, oxygen, sulfur, or is nonbonding; “m” denotes an integer of 0 to 8; Xs each represent an electron-withdrawing substituent; “n” denotes an integer of 1 to 9; and Y represents a bivalent organic group having 1 to 6 carbons. The monomer is useful as a monomer component typically for a highly functional polymer, because, when the monomer is applied to a resist resin, the resin is stable and resistant to chemicals, is highly soluble in organic solvents, and has improved hydrolyzability and/or solubility in water after hydrolysis.
    Type: Grant
    Filed: February 3, 2009
    Date of Patent: January 28, 2014
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Hiroshi Koyama, Kyuhei Kitao, Akira Eguchi
  • Patent number: 8546444
    Abstract: Natural and synthetic compounds having a lactone structure methods for alleviation of pain, especially pain associated with disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. Initial studies have shown that patients can be taken off of morphine when the preferred alpha-methylene-gamma-butyrolactone is administered in a dosage of between 60 and 120 mg/day intramuscularly.
    Type: Grant
    Filed: May 28, 2012
    Date of Patent: October 1, 2013
    Assignee: Magnachem International Laboratories, Inc.
    Inventors: Federico M. Gomez, C. Federico Gomez Garcia-Godoy
  • Patent number: 8536348
    Abstract: Compounds of Formulae Ia wherein R1-R9 taken independently are preferably a hydrogen atom, a halogen atom, a hydroxyl group, or any other organic groups or grouping, Z and X are independently and preferably a heteroatom such as oxygen, sulfur, or nitrogen groupings are useful for treatment of bacterial and fungal infections.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: September 17, 2013
    Assignee: Magnachem International Laboratories, Inc.
    Inventor: David Terrero
  • Publication number: 20130217898
    Abstract: The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ?-caprolactone was obtained at an isolated yield of 82%.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 22, 2013
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Kazuaki Ishihara, Muhammet Uyanik
  • Publication number: 20130115654
    Abstract: A method for utilizing agricultural biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from agricultural biomass for producing derivative products while minimizing waste products.
    Type: Application
    Filed: November 9, 2011
    Publication date: May 9, 2013
    Applicant: Thesis Chemistry, LLC
    Inventors: John R. Peterson, Christopher M. Yost, Jian Wu
  • Publication number: 20130115653
    Abstract: A method for utilizing woody biomass components, namely cellulose, hemicellose, and lignin, and converting them to value-added biobased chemical products is described herein. The present method provides treatments to obtain a plurality of component streams from woody biomass for producing derivative products while minimizing waste products.
    Type: Application
    Filed: November 9, 2011
    Publication date: May 9, 2013
    Applicant: Thesis Chemistry, LLC
    Inventors: John R. Peterson, Christopher M. Yost, Jian Wu
  • Patent number: 8425972
    Abstract: An antimicrobial material is provided for use in forming textiles, medical devices, packaging materials, and the like, or coatings thereon. In some embodiments, the antimicrobial material may be utilized for bulk modification of an article. The antimicrobial material includes a furanone possessing vinyl and/or acrylate functional groups, optionally in combination with another monomer possessing vinyl and/or acrylate groups.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: April 23, 2013
    Assignee: Covidien LP
    Inventor: Joshua B. Stopek
  • Patent number: 8404743
    Abstract: Disclosed are compounds comprising a zinc oxide molecule chemically bound to one or more molecules having an acidic hydrogen, such as an organic acid. The invention also provides compositions comprising such compounds and methods of preparing such compounds. The compounds of the invention may be provided in, for example, topical skin formulations, pharmaceutical compositions, or delivery systems for active ingredients.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: March 26, 2013
    Assignee: Mary Kay Inc.
    Inventor: James Swanzy
  • Publication number: 20130053582
    Abstract: ?-Hydroxycarboxylic esters and ?-lactones which are suitable as flavors can be prepared by electrochemical reductive cross-coupling of ?,?-unsaturated esters with carbonyl compounds in an undivided electrolysis cell having a cathode composed of lead, lead alloys, cadmium, cadmium alloys, mercury, steel, glassy carbon or boron-doped diamonds and a basic aqueous electrolyte comprising an electrolyte salt which suppresses the cathodic formation of hydrogen.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 28, 2013
    Applicant: BASF SE
    Inventors: Itamar Michael Malkowsky, Florian Stecker, Simone Lutter, Olivier Abillard, Ralf Pelzer
  • Patent number: 8383837
    Abstract: The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a polyhydroxy compound in the presence of a catalyst containing gold in a solvent.
    Type: Grant
    Filed: June 5, 2008
    Date of Patent: February 26, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Werner Bonrath, Jocelyn Fischesser
  • Publication number: 20130034646
    Abstract: The present invention relates to the use of a compound of having the following formula: wherein either 1 or 2 of the dotted lines represent a double bond, in order to provide or enhance buttery, creamy, green, fatty and/or milky note to flavors and foods.
    Type: Application
    Filed: May 17, 2011
    Publication date: February 7, 2013
    Applicant: FIRMENICH SA
    Inventors: Kasia Aeberhardt, Eric Frerot, Elise Sarrazin
  • Patent number: 8354265
    Abstract: The present invention concerns the field of bacterial biocontrol. More precisely, the invention relates to the identification of chemicals which promote the growth of bacteria inactivating NAHL, such as gamma-caprolactone (GCL) and 4-heptanolide (HTN) and their use in soil additives.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: January 15, 2013
    Assignees: Centre National de la Recherche Scientifique, Comite Economique Agricole Production des Plants du Nord (Comite Nord Pomme de Terre)
    Inventors: Denis Faure, Amélie Cirou, Yves Dessaux
  • Patent number: 8344151
    Abstract: Process for the preparation of 4-aminobut-2-enolide compounds of the formula (I): comprising reaction of a 4-alkoxyfuran-2(5H)-one compound or 4-arylalkoxyfuran-2(5H)-one compound of the formula (II) with an amine of the formula (III) in which R1, R2 and A have the definitions given in the description, in the presence of a Brønstedt acid.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: January 1, 2013
    Assignee: Bayer Cropscience AG
    Inventors: Norbert Lui, Jens-Dietmer Heinrich
  • Publication number: 20120329868
    Abstract: The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. The invention also relates to derivatives of lichesterinic acid of formula (A).
    Type: Application
    Filed: March 4, 2011
    Publication date: December 27, 2012
    Applicants: Centre National de la Recherche Scientifique - CNRS, Centre Hospitalier Universitaire Pontchaillou, Universite de Rennes 1
    Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le-Devehat, Marylene Chollet-Krugler, Sophie Tomasi
  • Publication number: 20120197030
    Abstract: The current invention relates to the structure, synthesis of dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate, as well as its applications in the palladium catalyzed carbon-chlorine bond activation for Suzuki coupling reactions and carbon-nitrogen bond formation reactions. The dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine or its tetrafluoroborate could coordinate with the palladium catalyst to activate the inert carbon-chlorine bond highly selectively and catalyze Suzuki coupling reaction with arylboronic acid or carbon-nitrogen bond formation reaction with organic amines. The current invention uses only one step to synthesize dialkyl(2,4,6- or 2,6-alkoxyphenyl)phosphine and its tetrafluoroborate is stable in the air. Compared with known synthetic routes of ligands used in activating carbon-chlorine bonds, the method of current invention is short, easy to operate.
    Type: Application
    Filed: December 21, 2009
    Publication date: August 2, 2012
    Applicant: Zhejiang University
    Inventors: Shengming Ma, Bo Lü, Chunling Fu
  • Patent number: 8188145
    Abstract: Natural and synthetic compounds having a lactone structure methods for alleviation of pain, especially pain associated with disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. Initial studies have shown that patients can be taken off of morphine when the preferred alpha-methylene-gamma-butyrolactone is administered in a dosage of between 60 and 120 mg/day intramuscularly.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: May 29, 2012
    Assignee: Magnachem International Laboratories, Inc.
    Inventors: Federico M. Gomez, C. Federico Gomez Garcia-Godoy
  • Patent number: 8177896
    Abstract: A novel chemical genus of furan-2-one antifouling compound as non-toxic, environment friendly antifouling agent, a coating material for objects submerged under the water based on the furan-2-one compounds. The substituted furan-2-one antifouling compounds have a furan-2-one ring and an alkyl side chain thereto and are of the formula: where n=6-14, representing the number of carbon atoms in said side chain.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: May 15, 2012
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Peiyuan Qian, Ying Xu, Xiaojian Zhou, Hongping He, Nobuhiro Fusetani, Wei-Min Dai
  • Publication number: 20110200848
    Abstract: Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particles to suspensions and/or via the surface modification of the solid in semi-solids (e.g., by coating the solid with a more electron conductive coating material to increase the power of the device). High energy density and high power redox flow devices are disclosed. The redox flow devices described herein can also include one or more inventive design features. In addition, inventive chemistries for use in redox flow devices are also described.
    Type: Application
    Filed: December 16, 2010
    Publication date: August 18, 2011
    Applicants: Massachusetts Institute of Technology, 24-M Technologies, Inc.
    Inventors: Yet-Ming Chiang, W. Craig Carter, Bryan Y. Ho, Mihai Duduta, Pimpa Limthongkul
  • Publication number: 20110190513
    Abstract: Three biosynthetic pathways are disclosed for microorganism bio-production of 1,4-Butanediol from various carbon sources. Exemplary methods are provided. The recombinant microorganisms comprising any of these 1,4-Butanediol biosynthesis pathways may also comprise genetic modifications directed to improved tolerance for 1,4-Butanediol.
    Type: Application
    Filed: July 8, 2009
    Publication date: August 4, 2011
    Inventor: Michael D. Lynch
  • Publication number: 20110185944
    Abstract: A novel chemical genus of furan-2-one antifouling compound as non-toxic, environment friendly antifouling agent, a coating material for objects submerged under the water based on the furan-2-one compounds. The substituted furan-2-one antifouling compounds have a furan-2-one ring and an alkyl side chain thereto and are of the formula: where n=6-14, representing the number of carbon atoms in said side chain.
    Type: Application
    Filed: April 16, 2009
    Publication date: August 4, 2011
    Inventors: Peiyuan Qian, Ying Xu, Xiaojian Zhou, Hongping He, Nobuhiro Fusetani, Wei-Min Dai
  • Publication number: 20110184059
    Abstract: The present invention relates to novel methylene furanone derivatives as well as the use thereof as a protective, antioxidant, or depigmentation agent in cosmetic or dermatological compositions. The invention also relates to a method for preparing said derivatives involving a Suzuki-Miyaura coupling reaction from corresponding dibromofuranone derivatives. The invention also relates to a method of preparation involving a coupling reaction of 2-methoxy-furan derivatives with a ketone followed by dehydration.
    Type: Application
    Filed: September 25, 2009
    Publication date: July 28, 2011
    Applicant: PIERRE FABRE DERMO-COSMETIQUE
    Inventors: Estelle Marchal, Philippe Uriac, Yves Brunel, Stéphane Poigny
  • Patent number: 7956088
    Abstract: Natural and synthetic compounds having a lactone structure methods for using and making the compounds have been disclosed. The compounds are useful as anti-bacterial, anti-fungal and anti-inflammatory agents, and for treating proliferation disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. The compounds are also effective for treatment or prevention of inflammatory diseases such as atherosclerosis, lung fibrosis, systemic lupus erythematosus, pancreatitis, sarcoidosis, glomerulitis, and organ transplant rejection. They are also effective for treatment or prevention of bacterial and fungal infections, including treatment of peptic ulcers, gastritis, dyspepsia and gastric cancer, gingivitis and periodontitis.
    Type: Grant
    Filed: November 29, 2007
    Date of Patent: June 7, 2011
    Assignee: Magnachem International Laboratories, Inc.
    Inventor: David Terrero
  • Patent number: 7947847
    Abstract: A method for modifying ethylenic unsaturation in a triglyceride. One or more unsaturated fatty acyl moieties present in the triglyceride are substituted with a lactone or ketone moiety via an electron acceptor mediated reaction. The resulting reaction products are useful, for example, as formulations for lubricants, hydraulic fluids, dielectric fluids, and intermediates for polymer synthesis.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: May 24, 2011
    Assignee: Bunge Oils, Inc.
    Inventors: Neil Wallace Higgins, Jerry F. Stults
  • Patent number: 7906130
    Abstract: The present invention provides a stable composition which comprises a non-hydroxyl-group-containing solvent mixture comprising N,N-diethyl-m-toluamide and ?-hexalactone, optionally with dimethyl sulfoxide, eucalyptol and 1-methoxy-2-propyl acetate; and an effective amount of each of amitraz and at least one additional parasiticidal compound, such as R-28153. Said composition allows for high concentrations of a mixture of parasiticidal agents in a single application and is useful for treating and controlling parasiticidal infection and infestation in a homeothermic animal.
    Type: Grant
    Filed: October 7, 2005
    Date of Patent: March 15, 2011
    Assignee: Wyeth LLC
    Inventors: Shobhan Shashi Sabnis, Jacob A. Zupan, Robert Bruce Albright
  • Publication number: 20100291275
    Abstract: A method of providing a flavour or a fragrance to a composition, which includes adding to the composition a compound of the formula I in which R1 and R3 are independently selected from at least one of H, C1-C10 straight chain alkyl or branched chain alkyl, and R2 and R4 are independently selected from at least one of C1-C10 straight chain alkyl or branched chain alkyl. Flavored and fragranced products including a compound of the Formula I are also provided.
    Type: Application
    Filed: March 15, 2007
    Publication date: November 18, 2010
    Inventors: Stefan Michael Furrer, Peter Schieberle, Andrea Burdack-Freitag
  • Patent number: 7824839
    Abstract: The invention provides various ionic and non-ionic photoacid generator compounds. Photoresist compositions that include the novel ionic and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for various microfabrication applications.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: November 2, 2010
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Christopher K. Ober, Yi Yi, Ramakrishnan Ayothi
  • Publication number: 20100266717
    Abstract: Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.
    Type: Application
    Filed: April 20, 2010
    Publication date: October 21, 2010
    Applicant: Marrone Bio Innovations, Inc.
    Inventors: Ratnakar Asolkar, Sarahann Dow, Huazhang Huang, Marja Koivunen, Pamela Marrone, Stephanie Shu
  • Patent number: 7763741
    Abstract: The subject invention provides a method for separating a terpene trilactone from Ginkgo biloba plant material or from an extract of Ginkgo biloba comprising a mixture of terpene trilactones, the process comprising the steps of: a) subjecting the Ginkgo biloba plant material or the extract to column chromatography with an appropriate solvent system to produce at least a first fraction containing the terpene trilactone bilobalide, a second fraction eluted after the first fraction containing the terpene trilactones GA and GB, and a third fraction eluted after the second fraction containing at least a preponderance of the terpene trilactones GC and GJ; and b) alkylating the terpene trilactone GB of the second fraction so as to produce a first mixture including terpene trilactone GA and alkylated terpene trilactone GB; or alkylating the terpene trilactone GC of the third fraction so as produce a second mixture including terpene trilactone GJ and alkylated terpene trilactone GC, so as to thereby isolate a terpen
    Type: Grant
    Filed: November 9, 2004
    Date of Patent: July 27, 2010
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Koji Nakanishi, Stanislav Jaracz, Shahid Malik, Hideki Ishii, Sergei V. Dzyuba
  • Patent number: 7759044
    Abstract: A dissolution modification agent suitable for use in a photoresist composition including a polymer, a photoacid generator and casting solvent. The dissolution modification agent is insoluble in aqueous alkaline developer and inhibits dissolution of the polymer in the developer until acid is generated by the photoacid generator being exposed to actinic radiation, whereupon the dissolution modifying agent, at a suitable temperature, becomes soluble in the developer and allows the polymer to dissolve in the developer. The DMAs are glucosides, cholates, citrates and adamantanedicarboxylates protected with acid-labile ethoxyethyl, tetrahydrofuranyl, and angelicalactonyl groups.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: July 20, 2010
    Assignee: International Business Machines Corporation
    Inventors: Robert David Allen, Phillip Joe Brock, Richard Anthony DiPietro, Ratnam Sooriyakumaran, Hoa D. Truong
  • Patent number: 7749679
    Abstract: A photosensitive composition containing a compound having a specific structure, a pattern-forming method using the photosensitive composition, and a compound having a specific structure used in the photosensitive composition.
    Type: Grant
    Filed: December 21, 2006
    Date of Patent: July 6, 2010
    Assignee: FUJIFILM Corporation
    Inventors: Kenji Wada, Kunihiko Kodama
  • Publication number: 20100130754
    Abstract: The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Ru complexes with bidentate ligands, having one amino or imino coordinating group and one phosphino coordinating group, in hydrogenation processes for the reduction of esters or lactones into the corresponding alcohol or diol respectively.
    Type: Application
    Filed: January 27, 2010
    Publication date: May 27, 2010
    Inventors: Lionel Saudan, Philippe Dupau, Jean-Jacques Riedhauser, Patrick Wyss