Plural Ring Oxygens In The Bicyclo Ring System Patents (Class 549/306)
  • Publication number: 20150098914
    Abstract: The invention relates to the use of specific glucuronolactone derivatives as self-tanning substances, as tanning enhancers for dihydroxyacetone or for a mixture of self-tanning substances comprising dihydroxyacetone, for modulation of the colour shade achieved in the case of tanning with dihydroxyacetone or by the mixture or preparation comprising dihydroxyacetone, as contrast-reduction agents or for colouring keratin-containing fibres, and to preparations or compositions for colouring keratin-containing fibres comprising these specific glucuronolactone derivatives.
    Type: Application
    Filed: November 10, 2012
    Publication date: April 9, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Christophe Carola, Tatjana Best
  • Patent number: 7994162
    Abstract: The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzodiazepine compounds, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds, and to intermediate precursors to such compounds.
    Type: Grant
    Filed: November 10, 2008
    Date of Patent: August 9, 2011
    Assignee: Sanofi-Aventis
    Inventors: Jidong Zhang, Frederico Nardi, Alain Commerçon
  • Patent number: 7576213
    Abstract: A hitherto unknown class of chemical compounds, 2H-furo[2,3-c]pyran-2-ones including derivatives and analogues thereof are disclosed herein. Methods for making compounds within said class are disclosed herein and includes, without limitation, at least the intermediates employed in the generation of said compounds. The invention also relates to the use of vinylogous 4H-pyrones, including but not limited to the hitherto unknown 2H-furo[2,3-c]pyran-2-ones. Disclosed herein are methods comprising the step of exposing biological plant material to at least a compound of the invention to promoting bioactivity within said material. In another aspect in methods for promoting growth of plant material in, for example, smoke-responsive plant species by exposing said material to a compound of the invention are disclosed herein. More specifically, methods comprising the use of these compounds for promoting seed germination of a plant, for example, a smoke-responsive plant, are disclosed herein.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: August 18, 2009
    Assignee: The University of Western Australia
    Inventors: Gavin Ray Flematti, Emilio Luciano Ghisalberti, Kingsly Wayne Dixon, Robert Donald Trengove
  • Publication number: 20090093459
    Abstract: The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzothiazepine compounds, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds and to intermediate precursors to such compounds.
    Type: Application
    Filed: November 10, 2008
    Publication date: April 9, 2009
    Applicant: SANOFI-AVENTIS
    Inventors: Jidong ZHANG, Yannick BENEDETTI, Frederico NARDI, Alain COMMERCON
  • Patent number: 6780887
    Abstract: The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating and/or preventing pathologies associated with ischemia or with mitochondrial deficiencies.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: August 24, 2004
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
    Inventors: Carine Michiels, Martine Redon, Jose Remacle
  • Patent number: 6670458
    Abstract: The present invention relates to a process for effectively preparing L-ribose, which is recognized as being highly important in relation to the development of new antiviral medicines, from 1,4-lactone compound.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: December 30, 2003
    Assignee: Hanchem Co., Ltd.
    Inventors: Sang Jo Lee, Myung Joon Seo, Nak Cheol Jeong, Gun Cheol Kim, Hyun Woung Hong, Sul A Kim
  • Patent number: 6500962
    Abstract: The present invention relates to a method for producing an &agr;-methylene-&ggr;-butyrolactone which is one of basic structures often shown in drugs such as an anti-cancer agent by reacting an alene compound having an aldehyde or ketone group with carbon monoxide via cyclization in a single step in the presence of a catalyst containing ruthenium, thereby improving total yield of the entire reaction and achieving effects of cost reduction.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: December 31, 2002
    Assignee: Sungkyunkwan University
    Inventors: Suk-Koo Kang, Kwang-Jin Kim
  • Patent number: 6448415
    Abstract: The present invention relates to a new process for effectively converting the chirality of 4- or 5-position carbon of a 1,4-lactone- or 1,5-lactone sugar compound which comprises reacting the lactone compound with secondary amine and sulfonyl group-containing compound. The compound of which chirality is converted according to the present invention can be advantageously used for preparing such expensive rare sugar compounds as L-ribose, D-talose, etc.
    Type: Grant
    Filed: July 20, 2001
    Date of Patent: September 10, 2002
    Assignee: Hanchem Co., Ltd.
    Inventors: Sang Jo Lee, Myung Joon Seo, Nak Cheol Jeong, Gun Cheol Kim, Hyun Woung Hong, Sul A Kim
  • Patent number: 6291687
    Abstract: Compounds of the formula I: wherein: A′ and A″ are independently the same or different group of the formula II: wherein: R′ is H.
    Type: Grant
    Filed: December 14, 1999
    Date of Patent: September 18, 2001
    Assignee: Medivir AB
    Inventors: Bjorn Classon, Ingemar Sven-Anders Kvarnstrom, Bengt Bertil Samuelsson
  • Patent number: 6268514
    Abstract: The use of nitroethane derivatives of the formula I where: R1 is hydrogen, unsubstituted or substituted C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl, halogen, cyano or thiocyanato; R2 is hydrogen, formyl; halogen- or C1-C3-alkoxy-substituted or unsubstituted C1-C6-alkylcarbonyl, C2-C6-alkenylcarbonyl, C4-C6-alkyldienylcarbonyl or C2-C6-alkynylcarbonyl; A is unsubstituted or substituted phenyl, naphthyl, quinolyl, quinazolyl, quinoxalyl, 1-methylindolyl, 1-methylbenzimidazolyl, 2-methylindazolyl, benzofuranyl, benzothienyl, benzoxazolyl, benzothiazolyl, furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl, pyranyl or thiopyranyl; as microbicides is described.
    Type: Grant
    Filed: June 13, 2000
    Date of Patent: July 31, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerhard Hamprecht, John-Bryan Speakman, Gisela Lorenz, Kurt Eger, Mathias Schmidt, Uta Witt
  • Patent number: 5856524
    Abstract: A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.
    Type: Grant
    Filed: December 18, 1997
    Date of Patent: January 5, 1999
    Assignee: The Lubrizol Corporation
    Inventors: Jeffery G. Dietz, Mark R. Baker, Paul E. Adams
  • Patent number: 5786490
    Abstract: A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.
    Type: Grant
    Filed: April 10, 1997
    Date of Patent: July 28, 1998
    Assignee: The Lubrizol Corporation
    Inventors: Jeffry G. Dietz, Mark R. Baker, Paul E. Adams
  • Patent number: 5739356
    Abstract: A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: April 14, 1998
    Assignee: The Lubrizol Corporation
    Inventors: Jeffry G. Dietz, Mark R. Baker, Paul E. Adams
  • Patent number: 5527822
    Abstract: A method of treatment of a mammal, including humans, suffering from traumatic brain injury, which comprises administering to the sufferer a therapeutically effective amount of a butyrolactone derivative.
    Type: Grant
    Filed: December 29, 1993
    Date of Patent: June 18, 1996
    Assignee: Forest Laboratories, Inc.
    Inventor: Stuart L. Scheiner
  • Patent number: 5488166
    Abstract: Provided by the present invention is a process for the biocatalytic synthesis of optically pure sphingosines from achiral starting material. The stereoisomers of sphingosine are prepared from chiral arene diols using stereospecific reaction techniques to obtain the desired sphingosine or derivative thereof.
    Type: Grant
    Filed: January 23, 1995
    Date of Patent: January 30, 1996
    Assignee: Virginia Tech Intellectual Properties, Inc.
    Inventor: Tomas Hudlicky
  • Patent number: 5442079
    Abstract: There are described improved processes for the synthesis of a desired lactone useful as a synthon, the improved processes comprising oxidizing a protected arene diol with permanganate and periodate or subjecting a substituted epoxydiol to periodate oxidation to yield the desired lactone.
    Type: Grant
    Filed: May 10, 1993
    Date of Patent: August 15, 1995
    Assignee: Virginia Polytechnic Institute and State University
    Inventors: Tomas Hudlicky, Martin Mandel
  • Patent number: 5332840
    Abstract: A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic - anti-vasospastic compounds. Novel intermediates are also provided.
    Type: Grant
    Filed: May 27, 1993
    Date of Patent: July 26, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Sharon D. Real, David R. Kronenthal
  • Patent number: 5102909
    Abstract: The compounds 2-(5-methylthiomethyl-2-furyl)-2-hydroxy-3-keto-4- dihydroxyethylbutyrolactone and 2-(5-methoxymethyl-2- furyl)-2-furyl(-2-hydroxy-3-keto-4-dihydroxyethylbutyrolactone and pharmaceutical compositions containing them are useful to regulate the immune response in mammals.
    Type: Grant
    Filed: June 11, 1990
    Date of Patent: April 7, 1992
    Assignee: Theracel Corporation
    Inventors: Robert W. Veltri, Gabor B. Fodor, Kawporn Sussangkarn
  • Patent number: 5098933
    Abstract: Michael addition products of ascorbic acid and selected unsaturated aldehydes and ketones are useful as immunomodulators in mammals.
    Type: Grant
    Filed: September 25, 1990
    Date of Patent: March 24, 1992
    Assignee: Theracel Corporation
    Inventors: Robert Veltri, Gabor B. Fodor
  • Patent number: 4816481
    Abstract: Disclosed herein is a cerebral-circulation-metabolism-function-improving agent which contains a 2,6-diphenyl-3,7-dioxabicyclo[3.3.0]octane derivative represented by the following formula as the effective ingredient: ##STR1## wherein, each of R.sub.1, R.sub.3, R.sub.4 and R.sub.6 represents a hydrogen atom or a lower alkoxyl group; each of R.sub.2 and R.sub.5 represents a hydrogen atom, a .beta.-D-glucosyl group or a hydroxyl group; and each of R.sub.7 and R.sub.8 represents an oxygen atom or two hydrogen atoms.
    Type: Grant
    Filed: July 21, 1987
    Date of Patent: March 28, 1989
    Assignee: Wakunaga Seiyaku Kabushiki Kaisha
    Inventors: Naoyuki Takasugi, Mitsuyasu Ushijima, Satoshi Inoue, Terukage Hirata
  • Patent number: 4620014
    Abstract: Novel 2-furylbutyrolactones are directly formed by reaction of 2,5-dialkoxy-2,5-dihydrofurans and 2,3-dihydroxybutenolides in aqueous media and recovering crystalline product from an anhydrous medium. These novel compounds and compositions containing same may be used for lymophocyte stimulation.
    Type: Grant
    Filed: September 29, 1983
    Date of Patent: October 28, 1986
    Assignee: National Foundation for Cancer Research
    Inventors: Albert Szent-Gyorgyi, Gabor B. Fodor
  • Patent number: 4581465
    Abstract: The invention is a process for the preparation of a 1,4-lactone of 3,6-anhydrohexanoic acid which comprises refluxing a 1,4- or 1,5-lactone of pentahydroxyhexanoic acid, or an aqueous solution of pentahydroxyhexanoic acid in an organic reaction media which azeotropes with water in the presence of an inorganic acid, under conditions such that a 1,4-lactone of 3,6-anhydrohexanoic acid is formed.
    Type: Grant
    Filed: March 16, 1984
    Date of Patent: April 8, 1986
    Assignee: The Dow Chemical Company
    Inventors: Stoil K. Dirlikov, Connie J. Schneider
  • Patent number: 4552895
    Abstract: The invention provides for certain compounds derived from ascorbic acid and their formulations which are useful in inhibiting angiogenesis in mammals.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: November 12, 1985
    Assignee: Eli Lilly and Company
    Inventors: Gary A. Koppel, Russell L. Barton, Stephen L. Briggs