Plural Ring Oxygens In The Bicyclo Ring System Patents (Class 549/306)
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Publication number: 20150098914Abstract: The invention relates to the use of specific glucuronolactone derivatives as self-tanning substances, as tanning enhancers for dihydroxyacetone or for a mixture of self-tanning substances comprising dihydroxyacetone, for modulation of the colour shade achieved in the case of tanning with dihydroxyacetone or by the mixture or preparation comprising dihydroxyacetone, as contrast-reduction agents or for colouring keratin-containing fibres, and to preparations or compositions for colouring keratin-containing fibres comprising these specific glucuronolactone derivatives.Type: ApplicationFiled: November 10, 2012Publication date: April 9, 2015Applicant: MERCK PATENT GMBHInventors: Christophe Carola, Tatjana Best
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Patent number: 7994162Abstract: The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzodiazepine compounds, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds, and to intermediate precursors to such compounds.Type: GrantFiled: November 10, 2008Date of Patent: August 9, 2011Assignee: Sanofi-AventisInventors: Jidong Zhang, Frederico Nardi, Alain Commerçon
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Patent number: 7576213Abstract: A hitherto unknown class of chemical compounds, 2H-furo[2,3-c]pyran-2-ones including derivatives and analogues thereof are disclosed herein. Methods for making compounds within said class are disclosed herein and includes, without limitation, at least the intermediates employed in the generation of said compounds. The invention also relates to the use of vinylogous 4H-pyrones, including but not limited to the hitherto unknown 2H-furo[2,3-c]pyran-2-ones. Disclosed herein are methods comprising the step of exposing biological plant material to at least a compound of the invention to promoting bioactivity within said material. In another aspect in methods for promoting growth of plant material in, for example, smoke-responsive plant species by exposing said material to a compound of the invention are disclosed herein. More specifically, methods comprising the use of these compounds for promoting seed germination of a plant, for example, a smoke-responsive plant, are disclosed herein.Type: GrantFiled: June 19, 2006Date of Patent: August 18, 2009Assignee: The University of Western AustraliaInventors: Gavin Ray Flematti, Emilio Luciano Ghisalberti, Kingsly Wayne Dixon, Robert Donald Trengove
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Publication number: 20090093459Abstract: The present invention relates to 2-alkoxy-3,4,5-trihydroxyalkylamide benzothiazepine compounds, to pharmaceutical compositions comprising such compounds, to methods of treatment comprising administering such compounds, to processes for the preparation of such compounds and to intermediate precursors to such compounds.Type: ApplicationFiled: November 10, 2008Publication date: April 9, 2009Applicant: SANOFI-AVENTISInventors: Jidong ZHANG, Yannick BENEDETTI, Frederico NARDI, Alain COMMERCON
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Patent number: 6780887Abstract: The present invention is related to a compound of formula (I), salts and pro-drugs of the compound (I) and methods for treating and/or preventing partial or total ischemia, methods for treating and/or preventing pathologies associated with ischemia or with mitochondrial deficiencies.Type: GrantFiled: July 30, 2002Date of Patent: August 24, 2004Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)Inventors: Carine Michiels, Martine Redon, Jose Remacle
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Patent number: 6670458Abstract: The present invention relates to a process for effectively preparing L-ribose, which is recognized as being highly important in relation to the development of new antiviral medicines, from 1,4-lactone compound.Type: GrantFiled: August 17, 2001Date of Patent: December 30, 2003Assignee: Hanchem Co., Ltd.Inventors: Sang Jo Lee, Myung Joon Seo, Nak Cheol Jeong, Gun Cheol Kim, Hyun Woung Hong, Sul A Kim
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Patent number: 6500962Abstract: The present invention relates to a method for producing an &agr;-methylene-&ggr;-butyrolactone which is one of basic structures often shown in drugs such as an anti-cancer agent by reacting an alene compound having an aldehyde or ketone group with carbon monoxide via cyclization in a single step in the presence of a catalyst containing ruthenium, thereby improving total yield of the entire reaction and achieving effects of cost reduction.Type: GrantFiled: March 15, 2002Date of Patent: December 31, 2002Assignee: Sungkyunkwan UniversityInventors: Suk-Koo Kang, Kwang-Jin Kim
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Patent number: 6448415Abstract: The present invention relates to a new process for effectively converting the chirality of 4- or 5-position carbon of a 1,4-lactone- or 1,5-lactone sugar compound which comprises reacting the lactone compound with secondary amine and sulfonyl group-containing compound. The compound of which chirality is converted according to the present invention can be advantageously used for preparing such expensive rare sugar compounds as L-ribose, D-talose, etc.Type: GrantFiled: July 20, 2001Date of Patent: September 10, 2002Assignee: Hanchem Co., Ltd.Inventors: Sang Jo Lee, Myung Joon Seo, Nak Cheol Jeong, Gun Cheol Kim, Hyun Woung Hong, Sul A Kim
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Patent number: 6291687Abstract: Compounds of the formula I: wherein: A′ and A″ are independently the same or different group of the formula II: wherein: R′ is H.Type: GrantFiled: December 14, 1999Date of Patent: September 18, 2001Assignee: Medivir ABInventors: Bjorn Classon, Ingemar Sven-Anders Kvarnstrom, Bengt Bertil Samuelsson
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Patent number: 6268514Abstract: The use of nitroethane derivatives of the formula I where: R1 is hydrogen, unsubstituted or substituted C1-C6-alkyl, C3-C6-alkenyl, C3-C6-alkynyl, halogen, cyano or thiocyanato; R2 is hydrogen, formyl; halogen- or C1-C3-alkoxy-substituted or unsubstituted C1-C6-alkylcarbonyl, C2-C6-alkenylcarbonyl, C4-C6-alkyldienylcarbonyl or C2-C6-alkynylcarbonyl; A is unsubstituted or substituted phenyl, naphthyl, quinolyl, quinazolyl, quinoxalyl, 1-methylindolyl, 1-methylbenzimidazolyl, 2-methylindazolyl, benzofuranyl, benzothienyl, benzoxazolyl, benzothiazolyl, furyl, thienyl, pyrrolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxazolyl, thiazolyl, imidazolyl, oxadiazolyl, thiadiazolyl, triazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl, pyranyl or thiopyranyl; as microbicides is described.Type: GrantFiled: June 13, 2000Date of Patent: July 31, 2001Assignee: BASF AktiengesellschaftInventors: Gerhard Hamprecht, John-Bryan Speakman, Gisela Lorenz, Kurt Eger, Mathias Schmidt, Uta Witt
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Patent number: 5856524Abstract: A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.Type: GrantFiled: December 18, 1997Date of Patent: January 5, 1999Assignee: The Lubrizol CorporationInventors: Jeffery G. Dietz, Mark R. Baker, Paul E. Adams
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Patent number: 5786490Abstract: A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.Type: GrantFiled: April 10, 1997Date of Patent: July 28, 1998Assignee: The Lubrizol CorporationInventors: Jeffry G. Dietz, Mark R. Baker, Paul E. Adams
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Patent number: 5739356Abstract: A process for preparing compounds useful as intermediates used for preparing lubricant and fuel additives. The intermediates include the products prepared by the process and dilactones.Type: GrantFiled: November 21, 1996Date of Patent: April 14, 1998Assignee: The Lubrizol CorporationInventors: Jeffry G. Dietz, Mark R. Baker, Paul E. Adams
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Patent number: 5527822Abstract: A method of treatment of a mammal, including humans, suffering from traumatic brain injury, which comprises administering to the sufferer a therapeutically effective amount of a butyrolactone derivative.Type: GrantFiled: December 29, 1993Date of Patent: June 18, 1996Assignee: Forest Laboratories, Inc.Inventor: Stuart L. Scheiner
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Patent number: 5488166Abstract: Provided by the present invention is a process for the biocatalytic synthesis of optically pure sphingosines from achiral starting material. The stereoisomers of sphingosine are prepared from chiral arene diols using stereospecific reaction techniques to obtain the desired sphingosine or derivative thereof.Type: GrantFiled: January 23, 1995Date of Patent: January 30, 1996Assignee: Virginia Tech Intellectual Properties, Inc.Inventor: Tomas Hudlicky
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Patent number: 5442079Abstract: There are described improved processes for the synthesis of a desired lactone useful as a synthon, the improved processes comprising oxidizing a protected arene diol with permanganate and periodate or subjecting a substituted epoxydiol to periodate oxidation to yield the desired lactone.Type: GrantFiled: May 10, 1993Date of Patent: August 15, 1995Assignee: Virginia Polytechnic Institute and State UniversityInventors: Tomas Hudlicky, Martin Mandel
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Patent number: 5332840Abstract: A method is provided for preparing a chiral benzaldehyde of the structure ##STR1## by acylating an anhydride of the structure ##STR2## with a chiral oxazolidine of the structure ##STR3## where Q is MgHal or Li, and X, Y and Z are as described herein, to form a keto acid which is reduced and cyclized. The resulting benzaldehyde may be used in making the final anti-thrombotic - anti-vasospastic compounds. Novel intermediates are also provided.Type: GrantFiled: May 27, 1993Date of Patent: July 26, 1994Assignee: Bristol-Myers Squibb CompanyInventors: Sharon D. Real, David R. Kronenthal
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Patent number: 5102909Abstract: The compounds 2-(5-methylthiomethyl-2-furyl)-2-hydroxy-3-keto-4- dihydroxyethylbutyrolactone and 2-(5-methoxymethyl-2- furyl)-2-furyl(-2-hydroxy-3-keto-4-dihydroxyethylbutyrolactone and pharmaceutical compositions containing them are useful to regulate the immune response in mammals.Type: GrantFiled: June 11, 1990Date of Patent: April 7, 1992Assignee: Theracel CorporationInventors: Robert W. Veltri, Gabor B. Fodor, Kawporn Sussangkarn
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Patent number: 5098933Abstract: Michael addition products of ascorbic acid and selected unsaturated aldehydes and ketones are useful as immunomodulators in mammals.Type: GrantFiled: September 25, 1990Date of Patent: March 24, 1992Assignee: Theracel CorporationInventors: Robert Veltri, Gabor B. Fodor
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Patent number: 4816481Abstract: Disclosed herein is a cerebral-circulation-metabolism-function-improving agent which contains a 2,6-diphenyl-3,7-dioxabicyclo[3.3.0]octane derivative represented by the following formula as the effective ingredient: ##STR1## wherein, each of R.sub.1, R.sub.3, R.sub.4 and R.sub.6 represents a hydrogen atom or a lower alkoxyl group; each of R.sub.2 and R.sub.5 represents a hydrogen atom, a .beta.-D-glucosyl group or a hydroxyl group; and each of R.sub.7 and R.sub.8 represents an oxygen atom or two hydrogen atoms.Type: GrantFiled: July 21, 1987Date of Patent: March 28, 1989Assignee: Wakunaga Seiyaku Kabushiki KaishaInventors: Naoyuki Takasugi, Mitsuyasu Ushijima, Satoshi Inoue, Terukage Hirata
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Patent number: 4620014Abstract: Novel 2-furylbutyrolactones are directly formed by reaction of 2,5-dialkoxy-2,5-dihydrofurans and 2,3-dihydroxybutenolides in aqueous media and recovering crystalline product from an anhydrous medium. These novel compounds and compositions containing same may be used for lymophocyte stimulation.Type: GrantFiled: September 29, 1983Date of Patent: October 28, 1986Assignee: National Foundation for Cancer ResearchInventors: Albert Szent-Gyorgyi, Gabor B. Fodor
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Patent number: 4581465Abstract: The invention is a process for the preparation of a 1,4-lactone of 3,6-anhydrohexanoic acid which comprises refluxing a 1,4- or 1,5-lactone of pentahydroxyhexanoic acid, or an aqueous solution of pentahydroxyhexanoic acid in an organic reaction media which azeotropes with water in the presence of an inorganic acid, under conditions such that a 1,4-lactone of 3,6-anhydrohexanoic acid is formed.Type: GrantFiled: March 16, 1984Date of Patent: April 8, 1986Assignee: The Dow Chemical CompanyInventors: Stoil K. Dirlikov, Connie J. Schneider
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Patent number: 4552895Abstract: The invention provides for certain compounds derived from ascorbic acid and their formulations which are useful in inhibiting angiogenesis in mammals.Type: GrantFiled: March 14, 1983Date of Patent: November 12, 1985Assignee: Eli Lilly and CompanyInventors: Gary A. Koppel, Russell L. Barton, Stephen L. Briggs