Nitrogen Attached Directly Or Indirectly To The Lactone Ring By Acyclic Nonionic Bonding Patents (Class 549/321)
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Patent number: 5043457Abstract: Compounds of the formula ##STR1## in which R is alkyl, arylalkyl or substituted arylkalkyl, or alkenyl containing one or more olephinic bonds; X is O, NH or NR.sub.1, where R.sub.1 is alkyl of 1 to 20 carbons or arylalkyl; and Y is H, alkyl of 1 to 20 carbons, arylalkyl, aryl, substituted aryl, substituted arylalkyl, alkenyl containing one or more olephinic bonds PO(OH).sub.2, PO(OH)OR.sub.2, PO(OH)R.sub.2 PO(OR.sub.2).sub.2, where R.sub.2 is independently alkyl of 1 to 20 carbons, phenyl, or substituted phenyl, further Y is CO--R.sub.3, CO--OR.sub.3, CONHR.sub.3, SO.sub.2 R.sub.3, SO.sub.2 NHR.sub.3, (CH.sub.2).sub.n --O--R.sub.3, or (CH.sub.2).sub.n --O--(CH.sub.2).sub.m --O--R.sub.3, where n, and m, are integers and are independently 1 to 20 and R.sub.3 is H, alkyl, alkenyl containing one or more olephinic bonds, aryl, substituted aryl, arylalkyl or substituted arylalkyl, with the proviso that when Y is CO--R.sub.3, CO--OR.sub.3, and CONHR.sub.3 then R.sub.3 is not hydrogen, are disclosed.Type: GrantFiled: April 17, 1990Date of Patent: August 27, 1991Assignee: Allergan, Inc.Inventor: Gary C. M. Lee
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Patent number: 5023351Abstract: Disclosed are .alpha.-(.omega.-Cyanoalkanoyl)-.gamma.-butyrolactone represented by the formula: ##STR1## wherein n represents an integer of 7 to 11, and a method for producing the same, which comprises reacting .omega.-cyano fatty acid ester represented by the formula:NC--(CH.sub.2).sub.n --COOR (II)wherein R represents an alkyl group having 1 to 4 carbon atoms and n has the same meaning as in the above, with .gamma.-butyrolactone in the presence of alkali metal alcoholate represented by the formula:R'OM (III)wherein R' represents an alkyl group having 1 to 4 carbon atoms and M represents an alkali metal.Type: GrantFiled: May 29, 1990Date of Patent: June 11, 1991Assignee: Ube Industries, Ltd.Inventors: Hiroshi Yoshida, Noboru Kakeya, Masanori Kashiwagi
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Patent number: 5013850Abstract: Compounds of Formula 1, and of Formula 2, ##STR1## in which R.sub.1 is H or alkyl of 1 to 20 carbon, CO--R.sub.1 * CO--O--R.sub.1 * CO--NH--R.sub.1 * or PO(OR.sub.1 *).sub.2 or PO(OR.sub.1 *)R.sub.1 * where R.sub.1 * independently is alkyl of 1 to 20 carbons, phenyl, or substituted phenyl; X is long chain alkyl having at least 5 carbon atoms, long chain alkyl of at least 5 carbons substituted with an aryl group, or long chain alkyl of at least 5 carbons substituted with a substituted aryl group; Y is COOH, COOR.sub.2, CONH.sub.2, CONHR.sub.2, CON(R.sub.2).sub.2, CHO, COR.sub.2 ; COCF.sub.3, COCHF.sub.2, CH.dbd.NR.sub.2, CR.sub.2 .dbd.N--R.sub.2, CH.dbd.N--NHR.sub.2, CH.dbd.N--N(R.sub.2).sub.2, CH.dbd.NOH, CR.sub.2 .dbd.N--OH, CH.dbd.NOR.sub.2, CR.sub.2 .dbd.NOR.sub.2, CH.sub.2 OH, CHR.sub.2 OH, C(R.sub.2).sub.2 OH, CH.sub.2 OR.sub.2 * CHR.sub.2 OR.sub.2 * C(R.sub.2).sub.2 OR.sub.2 * SO.sub.2 R.sub.2, PO(OR.sub.3).sub.2, and PS(OR.sub.3).sub.2, where R.sub.Type: GrantFiled: March 30, 1990Date of Patent: May 7, 1991Assignee: Allergan, Inc.Inventor: Gary C. M. Lee
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Patent number: 4996316Abstract: A process for the preparation of tertiary N,N-dimethylamines by the reaction of primary amines, formaldehyde, and hydrogen under pressure and at elevated temperature in the presence of a nickel-containing hydrogenation catalyst in the liquid phase. The hydrogenation catalyst is suspended in a solvent, the nickel concentration is 0.1 to 10% by weight, based on the primary amine. The starting materials are separate from each other, brought to 80.degree. to 150.degree. C. and 1 to 15 MPa and fed into the catalyst suspension simultaneously with stirring and reacted in one step to form the tertiary N,N-dimethylamines.Type: GrantFiled: December 24, 1988Date of Patent: February 26, 1991Assignee: Hoechst AktiengesellschaftInventors: Jurgen Weber, Detlef Kampmann, Claus Kniep
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Patent number: 4992562Abstract: A series of novel polypeptide derivatives, containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues, which are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin. Particularly valuable precursors for many of these compounds are certain other 5-amino-2,5-disubstituted-4-hydroxypentanoic acid derivatives.Type: GrantFiled: March 22, 1990Date of Patent: February 12, 1991Assignee: Pfizer Inc.Inventors: Edward F. Kleinman, Robert L. Rosati, Jasjit S. Bindra
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Patent number: 4950666Abstract: The present invention discloses compounds of the formula ##STR1## in which R is a 1,1-difluoroalkyl group or a 1,1-difluoroethenyl group having an even numbered carbon chain length of from 4 to 22 carbon atoms, pesticidal compositions thereof; and their use to control plant pests such as insects, acarids, and nematodes.Type: GrantFiled: March 30, 1989Date of Patent: August 21, 1990Assignee: FMC CorporationInventors: Clinton J. Peake, Thomas G. Cullen, Anthony J. Martinez
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Patent number: 4935530Abstract: A process for preparing 5-substituted-3-furaldehydes which comprises reacting 3-furaldehyde with lithium morpholide, followed by sec-butyl lithium, followed by an electrophile.Type: GrantFiled: October 18, 1988Date of Patent: June 19, 1990Assignee: Allergan, Inc.Inventor: Gary C. M. Lee
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Patent number: 4918187Abstract: The present invention relates to compounds of the formula ##STR1## wherein R.sub.c is carboxy, esterified carboxy or amidated carboxy; R.sub.2 is hydrogen or lower alkyl or joins with R.sub.a and R.sub.b and the atoms therebetween to form a fused ring ##STR2## and either R.sub.a is methyl and R.sub.b is ##STR3## or R.sub.2 and R.sub.b and the atoms therebetween form a group ##STR4## wherein R.sub.3 and R.sub.4 are either both hydrogen, or together are propylene, butylene, or with the two atoms to which they are attached form a benzene ring. Methods of manufacture and use thereof in the production of angiotensin converting enzyme inhibitors are disclosed.Type: GrantFiled: September 27, 1988Date of Patent: April 17, 1990Assignee: Ciba-Geigy CorporationInventor: Stephen K. Boyer
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Patent number: 4912220Abstract: Nitroaryl carbonyl Formula (IIA) compounds, their nitrodihydroaryl carbonyl Formula (I) intermediates, processes for preparing Formula (II) compounds, and a process for preparing Formula (I) compounds, wherein each process comprises the reaction of a nitroaryl compound with a silane.Type: GrantFiled: February 3, 1988Date of Patent: March 27, 1990Assignee: E. I. Du Pont de Nemours and CompanyInventor: Thaliyil V. Rajanbabu
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Patent number: 4910322Abstract: Geminal dinitro compounds are prepared by reacting an organic nitro compound having a replaceable hydrogen on the carbon to which the nitro group is attached with a source of nitrite ions in the presence of an oxidizing agent and a catalytic amount of an alkali metal ferricyanide.Type: GrantFiled: July 15, 1988Date of Patent: March 20, 1990Assignee: The United States of America as represented by the Secretary of the Air ForceInventors: Vytautas Grakauskas, Lee C. Garver, Kurt Baum
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Patent number: 4898977Abstract: The invention relates to novel processes and intermediates for the preparation of 5-amino-4-hydroxyvaleric acid derivatives of the formula ##STR1## in which R.sup.1 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl or the radical of a natural amino acid, R.sup.2 represents hydrogen, optionally substituted alkyl, cycloalkyl, cycloalkyl-lower alkyl, aryl, aryl-lower alkyl, amino, hydroxy, mercapto, sulphinyl, sulphonyl or the radical of a natural amino acid, and R.sup.3 represents optionally substituted hydroxy or amino, by sigmatropic rearrangement of a suitable allyl ester, halolactonisation of the resulting .gamma.,.delta.-unsaturated acid or of a suitable derivative thereof, exchange of halogen for a nitrogen-containing nucleophile, opening of the lactone ring and freeing of the amino group. Compounds of the formula I are starting materials for the preparation of renin-inhibitors which have an anti-hypertensive action.Type: GrantFiled: August 13, 1987Date of Patent: February 6, 1990Assignee: Ciba-Geigy CorporationInventors: Peter Herold, Christof Angst
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Patent number: 4876359Abstract: Novel .gamma.-butyrolactone derivatives having strong ACE inhibitory activity are provided. They are represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and mean individually a hydrogen atom or a straight-chain or branched alkyl or cycloalkyl group, or R.sup.1 and R.sup.2 are bonded together to mean an alkylene group having 2-6 carbon atoms, R.sup.3 denotes a hydrogen atom or a lower alkyl, aralkyl, amino lower alkyl or lower alkoxycarbonylamino lower alkyl group, R.sup.4 means a lower alkyl, cycloalkyl or aralkyl group, R.sup.5 means a hydrogen atom or a lower alkyl group, or R.sub.4 and R.sub.5 are bonded together to denote an alkylene group having 2-4 carbon atoms, and R.sup.6 stands for a hydrogen atom or a lower alkyl or aralkyl group; or a pharmacologically acceptable salt thereof.Type: GrantFiled: October 1, 1987Date of Patent: October 24, 1989Assignee: SS Pharmaceutical Co., Ltd.Inventors: Hiroshi Hasegawa, Noriaki Shioiri, Tadashi Narita, Tatsuhiko Katori
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Patent number: 4831166Abstract: .gamma.-butyrolactones of the general formula I ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms which may be substituted by lower alkoxy or acyloxy and R.sup.2 is hydrogen or straight-chain or branched alkyl which is unsubstituted or substituted by a functional group or is aryl, are prepared by reacting an alkylene oxide of the general formula II ##STR2## with an acylacetate of the general formla III ##STR3## where R.sup.1 and R.sup.2 have the above meanings and R.sup.3 and R.sup.4 are each alkyl of 1 to 6 carbon atoms or aryl, and R.sup.4 may furthermore be hydrogen, in the presence of a catalyst at elevated temperatures, by a process in which the reaction is carried out in the presence of an alkali metal halide, of an ammonium halide, preferably a quaternary ammonium halide, of a phosphonium halide, of an alkali metal phosphate or of an alkali metal carbonate at from 20.degree. to 200.degree. C. and under from 1 to 50 bar.Type: GrantFiled: May 8, 1987Date of Patent: May 16, 1989Assignee: BASF AktiengesellschaftInventors: Heinz Eckhardt, Walter Gramlich, Walter Best, Klaus Halbritter
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Patent number: 4783222Abstract: A surface treatment composition for glass fibers comprising an aqueous solution or emulsion of an organosilane which contains at least one isoimido group. The organosilane with the highest adhesion promotion is N-2-(isomaleimodo)aminoethyl-3-aminopropyl-trimethylsilane.Type: GrantFiled: November 17, 1987Date of Patent: November 8, 1988Assignee: International Business Machines CorporationInventor: Frank Druschke
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Patent number: 4774334Abstract: Compounds possessing antiallergy activity have the formula: ##STR1## wherein R and R.sup.1 are independently hydrogen or alkyl, or R and R.sup.1 together with the attached nitrogen form a heterocyclic ring system selected from the group consisting of piperidinyl, pyrrolidinyl, morpholinyl and 1, 2, 3, 4-tetrohydroquinolinyl, and R.sup.2 is phenyl or phenyl monosubstituted with a lower alkyl, a nitro, a halogenated methyl, a halogen or a lower alkoxy group.Type: GrantFiled: November 9, 1987Date of Patent: September 27, 1988Assignee: Pennwalt CorporationInventors: Vassil S. Georgiev, Thomas R. DeCory
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Patent number: 4743690Abstract: Nitroaryl carbonyl Formula (IIA) compounds, their nitrodihydroaryl carbonyl Formula (I) intermediates, processes for preparing Formula (II) compounds, and a process for preparing Formula (I) compounds, wherein each process comprises the reaction of a nitroaryl compound with a silane.Type: GrantFiled: January 16, 1987Date of Patent: May 10, 1988Assignee: E. I. Du Pont de Nemours and CompanyInventor: Thaliyil V. Rajanbabu
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Patent number: 4728669Abstract: 3-(N-acyl-N-arylamino)-gamma-butyrolactones and thiobutyrolactones have fungicidal activity.Type: GrantFiled: February 22, 1979Date of Patent: March 1, 1988Assignee: Chevron Research CompanyInventor: David C. K. Chan
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Patent number: 4721797Abstract: N-acyl-N-alkyl-2,6-dialkyl-3-chloroanilines of the formula ##STR1## wherein R.sub.1 is methyl or ethyl, R.sub.2 is alkoxymethyl, chloromethyl or 2-tetrahydrofuryl, R.sub.3 is alkoxymethyl, carboxy or alkoxycarbonyl and R.sub.4 is hydrogen or methyl and, if R.sub.3 is carboxy or alkoxycarbonyl, R.sub.4 is also 2-alkoxyethyl and 2-alkoxypropyl, and R.sub.3 and R.sub.4, together with the carbon atom to which both radicals are attached, may also form a 2-oxotetrahydro-3-furyl radical or a 2-oxo-5-methyltetrahydro-3-furyl radical, are prepared by reacting a 2,6-dialkylaniline of the formula ##STR2## with a halide of the formula ##STR3## wherein X is chlorine or bromine, to give an N-alkyl-2,6-dialkylaniline of the formula ##STR4## then converting said compound by further reaction with an acylating agent of the formulaX.sub.1 --CO--R.sub.2wherein X.sub.1 is chlorine, bromine or -O-CO-R.sub.Type: GrantFiled: September 2, 1986Date of Patent: January 26, 1988Assignee: Ciba-Geigy CorporationInventors: Wolfgang Eckhardt, Hans Suess
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Patent number: 4659862Abstract: Nitroaryl carbonyl Formula (IIA) compounds, their nitrodihydroaryl carbonyl Formula (I) intermediates, processes for preparing Formula (II) compounds, and a process for preparing Formula (I) compounds, wherein each process comprises the reaction of a nitroaryl compound with a silane.Type: GrantFiled: May 3, 1984Date of Patent: April 21, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventor: Thaliyil V. Rajanbabu
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Patent number: 4625040Abstract: Compounds which possess antiallergy activity have the formula: ##STR1## wherein R is selected from phenyl and phenyl mono or disubstituted with lower alkyl, nitro, halogenated methyl, halogen, lower alkoxy and combinations thereof;wherein R.sup.1 is selected from hydrogen and lower alkyl; andwhere R.sup.2 is selected from phenyl, phenyl monosubstituted with lower alkyl, nitro, halogenated methyl, halogen, and lower alkoxy, and trans-phenylcyclopropyl in which the phenyl group may be substituted with lower alkyl or halogen.Type: GrantFiled: March 13, 1986Date of Patent: November 25, 1986Assignee: Pennwalt CorporationInventors: Vassil S. Georgiev, Robert A. Mack
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Patent number: 4600775Abstract: Novel isomaleimido and isophthalimido derivatives of chromophoric compounds are provided which are useful in analytical techniques for the detection and measurement of biological compounds such as bacteria, enzymes, hormones and the like.Type: GrantFiled: August 27, 1984Date of Patent: July 15, 1986Inventor: Spyros Theodoropulos
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Patent number: 4599351Abstract: 3-(N-butyryl or valeryl-N-arylamino)-gamma-butyrolactones and their thio analogs. These compounds are useful as fungicides.Type: GrantFiled: February 1, 1984Date of Patent: July 8, 1986Assignee: Chevron Research CompanyInventor: David C. K. Chan
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Patent number: 4585789Abstract: Described are compounds of the formula: ##STR1## Wherein A is a lower alkylene group;R.sup.1 is a carboxy, hydroxy, lower alkoxycarbonyl, lower alkoxycarbonylamino, phenyl(lower)alkyloxy, benzoyloxy or lower alkanoyloxy group;R.sup.2 is a hydrogen or halogen atom or a halo(lower)alkyl group;R.sup.3 is a hydrogen or halogen atom;R.sup.4 is hydroxy, lower alkoxy, lower alkanoyloxy or lower alkoxycarbonyloxy group; andR.sup.5 is a hydrogen or halogen atom;Q is the number of double bonds which is equal to 0 or 1;n is an integer of 0 or 1, provided that when Q is 0, n is 1 and when Q is 1, n is 0.Type: GrantFiled: June 29, 1983Date of Patent: April 29, 1986Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Masanori Okamoto, Itsuo Uchida, Kazuyoshi Umehara, Masanobu Kohsaka, Hiroshi Imanaka
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Patent number: 4564629Abstract: N-Acylated N-phenyl-aminotetrahydro-2-furanones of the formula ##STR1## wherein R represents C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.1 represents C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.2 represents hydrogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.4 -alkoxy or halogen,R.sub.3 represents hydrogen or methyl, with the total number of C atoms of the substituents R, R.sub.1, R.sub.2 and R.sub.3 in the phenyl ring not exceeding the number 8,R.sub.4 represents hydrogen or methyl, whileR.sub.5 represents one of the following groups: an alkylthioalkyl or alkoxyalkyl group having 2 to 5 carbon atoms or an alkoxyalkoxymethyl group having a maximum of 6 carbon atoms, a 2-furanyl or 2-tetrahydrofuranyl group optionally substituted by halogen, a 1,2,4-triazolylmethyl group, a 1,2-pyrazolylmethyl group, or a group --CH.sub.2 --OR.sub.6 in which R.sub.6 represents a 5- or 6-membered heterocycle having oxygen as the hetero atom.are valuable fungicidal active substances.Type: GrantFiled: August 22, 1980Date of Patent: January 14, 1986Assignee: Ciba-Geigy CorporationInventors: Walter Kunz, Wolfgang Eckhardt, Adolf Hubele
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Patent number: 4537905Abstract: Substituted oximinoacetanilides of the general formula ##STR1## in which R.sup.1 denotes an alkyl or alkoxy group or a halogen atom,R.sup.2 denotes a hydrogen or halogen atom or an alkyl or trifluoromethyl group,R.sup.3 denotes a hydrogen or halogen atom or an alkyl group,R.sup.4 denotes a hydrogen atom or a methyl group,R.sup.5 denotes an alkoxy, amino or --NH--CO--NH--R.sup.7 group,whereinR.sup.7 represents a hydrogen atom or an optionally cyano-, alkoxy- or alkoxycarbonyl-substituted alkyl group, or represents a cycloalkyl group, andR.sup.6 denotes various aliphatic or heterocyclic radicals, are new and find use as pest-combating agents, in particular as fungicides.Type: GrantFiled: January 27, 1983Date of Patent: August 27, 1985Assignee: Bayer AktiengesellschaftInventors: Wilhelm Brandes, Werner Daum
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Patent number: 4508731Abstract: Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or .alpha.-naphthyl, each of which is further substituted,R.sub.1 is 2-furyl, 2-tetrahydrofuryl, alkenyl, cyclopropyl, .beta.-alkoxyethyl, hydroxymethyl, triazolylmethyl, imidazolylmethyl, pyrazolylmethyl, alkylsulfinyl, alkylsulfonyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, alkylsulfinyloxy, dialkylaminosulfinyloxy, phosphoric or thiophosphoric esters or amides, or alkylcarbonyloxy, andR.sub.9 is hydrogen or methyl,are microbicidally, in particular fungicidally active. The preferred compounds are those in which Ar is 2-methylphenyl, 2-methoxyphenyl, 2-chlorophenyl or .alpha.-naphthyl, each of which is further substituted by azido, and R.sub.9 is hydrogen.Type: GrantFiled: February 13, 1984Date of Patent: April 2, 1985Assignee: Ciba Geigy CorporationInventors: Peter Riebli, Hanspeter Fischer, Rudolph C. Thummel, Adolf Hubele
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Patent number: 4448773Abstract: Compounds of the formula ##STR1## in which Ar is 2-alkyl-, -alkoxy- or -halo-methyl-phenyl or .alpha.-naphthyl, each of which is further substituted,R.sub.1 is 2-furyl, 2-tetrahydrofuryl, alkenyl, cyclopropyl, .beta.-alkoxyethyl, hydroxymethyl, triazolylmethyl, imidazolylmethyl, pyrazolylmethyl, alkylsulfinyl, alkylsulfonyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, alkylsulfinyloxy, dialkylaminosulfinyloxy, phosphoric or thiophosphoric esters or amides, or alkylcarbonyloxy,R.sub.7 is hydrogen or optionally-substituted methyl or ethyl, andR.sub.8 is alkyl optionally substituted by alkoxy,are microbicidally, in particular fungicidally, active. Preferred compounds are those in which Ar is 2-methylphenyl, 2-methoxyphenyl, 2-chlorophenyl or .alpha.-naphthyl, each of which is further substituted by azido, and each of R.sub.7 and R.sub.8 is methyl.Type: GrantFiled: April 22, 1982Date of Patent: May 15, 1984Assignee: Ciba-Geigy CorporationInventors: Peter Riebli, Hanspeter Fischer, Rudolph C. Thummel, Adolf Hubele
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Patent number: 4440780Abstract: 3-(N-acyl-N-arylamino) and 3-(N-thionoacyl-N-arylamino)-gamma-butyrolactones and thiobutyrolactones have fungicidal activity.Type: GrantFiled: June 1, 1979Date of Patent: April 3, 1984Assignee: Chevron Research CompanyInventor: David C. K. Chan
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Patent number: 4434294Abstract: Novel imino derivatives of esters of 3-formyl-cyclopropane-1-carboxylic acids in their various isomeric forms and mixtures thereof of the formula ##STR1## wherein Z is an organic residue of a primary amine of the formula Z--NH.sub.2 and the acid moiety may have the cis or trans configuration and the alcohol moiety may have the R,S or RS configuration, novel intermediates therefore and a process for the preparation of the corresponding 3-substituted vinyl esters having insecticidal activity.Type: GrantFiled: October 1, 1981Date of Patent: February 28, 1984Assignee: Roussel UclafInventors: Jacques Martel, Jean Tessier, Andre Teche
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Patent number: 4423236Abstract: Novel condensation products between enediol ketolactones such as 5,6-0-isopropylidene ascorbic acid and 2-chloroethyl isocyanates are shown to have potent antitumor activity probably without the release of alkylating agents in vivo. While the structures of the products are not readily elucidated, activity is found to exceed that of BCNU (bis-(2-chloroethyl)-N-nitrosourea) and parallel that of the toxic and highly effective nitrosourea, MeCCNU (1-(4-trans-methylcyclohexyl)-3-(2-chloroethyl)-3-nitrosourea). Preferred compounds are condensation products of ##STR1## wherein R.sub.2 and R.sub.3 are a lower alkyl group containing 1 to 3 carbon atoms or H andhal--CH.sub.2 --CH.sub.2 --N.dbd.C.dbd.O (B)wherein hal is I, Br or Cl.Type: GrantFiled: October 23, 1981Date of Patent: December 27, 1983Assignee: National Foundation for Cancer Research, Inc.Inventor: Andrew J. Welebir
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Patent number: 4407817Abstract: 3-(N-acyl-N-arylamino) and 3-(N-thionoacyl-N-arylamino)-gamma-butyrolactones and thiobutyrolactones have fungicidal activity.Type: GrantFiled: April 19, 1982Date of Patent: October 4, 1983Assignee: Chevron Research CompanyInventor: David C. K. Chan
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Patent number: 4396775Abstract: This invention is related to homoserine aldehyde derivatives represented by the formula (I) which is important intermediate for producing mugineic acid, 2'-deoxymugineic acid, avenic acid A and homologue.Type: GrantFiled: December 21, 1981Date of Patent: August 2, 1983Assignee: Suntory LimitedInventors: Yasufumi Ohfune, Masako Tomita, Kyosuke Nomoto
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Patent number: 4350637Abstract: Novel substituted lactones of amino acids in all their possible stereoisomeric forms or mixtures thereof of the formula ##STR1## wherein A is a hydrocarbon chain of 1 to 10 chain members containing one or more heteroatoms and one or more unsaturations and the chain members being a mono- or polycyclic system or comprises a system of spiro or endo type and may contain one or more chiral atoms or the lactone copula can present a supplementary chirality due to the asymetric spatial configuration of the molecule make up and R is selected from the group consisting of: ##STR2## wherein Z is the organic remainder of an amino acid of the formula: ##STR3## Y is derived from a primary, secondary or tertiary alcohol of the formula Y-OH and B is the remainder of a heterocycle amino acid of 3 to 6 carbon atoms of the formula: ##STR4## and their preparation and their use for the resolution of amino acids.Type: GrantFiled: December 3, 1980Date of Patent: September 21, 1982Assignee: Roussel UclafInventors: Jacques Martel, Jean Tessier, Andre Teche
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Patent number: 4349378Abstract: Sulphonanilides of formula ##STR1## and salts thereof, wherein R.sup.1 represents alkyl or certain other groups;R represents alkylene or alkenylene;A represents --COR.sup.12 or a carbonyl derivative or addition compound thereof, where R.sup.12 represents hydrogen, alkyl or certain other groups; andR.sup.2 -R.sup.6 represent hydrogen, alkyl, halogen or certain other groups;are pesticides and plant growth regulants, especially herbicides and fungicides.Type: GrantFiled: December 14, 1978Date of Patent: September 14, 1982Assignee: FBC LimitedInventors: Geoffrey R. Cliff, Russell G. Hunt, Albert Percival
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Patent number: 4338450Abstract: Carbamate-sulfenyl-carba moyl fluoride compounds are valuable insecticidal compositions and are also useful intermediates in the production of bis-carbamate compounds.Type: GrantFiled: December 1, 1975Date of Patent: July 6, 1982Assignee: Union Carbide CorporationInventor: Themistocles D. J. D'Silva
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Patent number: H253Abstract: Energetic branched polynitrodiols of the formula ##STR1## wherein Z is --C(NO.sub.2).sub.3, --CF(NO.sub.2).sub.2, --C(NO.sub.2).su CH.sub.3, or --N(NO.sub.2)CH.sub.3, and a method of preparation. These diols are useful as components of energetic binders for plastic-bonded explosives.Type: GrantFiled: June 17, 1986Date of Patent: April 7, 1987Assignee: The United States of America as represented by the Secretary of the NavyInventors: Michael E. Sitzmann, William H. Gilligan