Chalcogen Attached Indirectly To The Lactone Ring By Nonionic Bonding Patents (Class 549/323)
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Patent number: 10858307Abstract: Provided herein are compositions and methods of treating liver cancer by novel anticancer agents.Type: GrantFiled: February 16, 2017Date of Patent: December 8, 2020Assignee: Golden Biotechnology CorporationInventors: Sheng-Yung Liu, Chih-Ming Chen
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Patent number: 9139789Abstract: A method for producing a petroleum substitute through a solvent extraction of woody tree material is provided. A raw biomass of woody tree material is processed into solvent-permeable wood particles and chips. Naturally occurring hydrocarbons suitable for use as a petroleum substitute are extracted by a mixture of polar and non-polar organic solvents in a counterflow operation. The extracted hydrocarbon oils are then separated from the solvent for use as a petroleum substitute, while the solvent is reused in the extraction process.Type: GrantFiled: June 4, 2011Date of Patent: September 22, 2015Assignee: Phytoleum Technologies Group, LLCInventor: Stephen Daniel Matthews
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Publication number: 20150093345Abstract: An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.Type: ApplicationFiled: March 27, 2013Publication date: April 2, 2015Inventors: Yuya Hayashi, Yoko Mizutare
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Publication number: 20150030577Abstract: Provided are compounds and compositions derived from Pseudomonas sp., particularly, Pseudomonas fluorescens or Pseudomonas protegens and more particularly strain having the identifying characteristics of Pseudomonas ATCC 55799 having antimicrobial properties and particularly, antibacterial properties.Type: ApplicationFiled: February 27, 2013Publication date: January 29, 2015Applicant: Marrone Bio Innovations, Inc.Inventors: Ratnakar Asolkar, Ana Lucia Cordova-Kreylos, Carly Todd
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Publication number: 20150018567Abstract: Provided herein are processes of preparing cyclohexenone compounds useful for cancer treatments and/or diseases.Type: ApplicationFiled: February 20, 2014Publication date: January 15, 2015Applicant: Golden Biotechnology CorporationInventors: Sheng-Yung Liu, Wu-Che Wen, Chih-Ming Chen, Hsiu-Yi Cheng
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Publication number: 20140343039Abstract: There is provided a process for preparing cephalotaxine esters corresponding to the following general formula I, which comprises the cephalotaxine backbone, and that can be written as C(R1)(R2)(XH)COO[CTX], wherein CTX represents the cephalotaxine backbone, being optionally substituted, the process consisting in bringing the corresponding cephalotaxine compound, or salts, isomers or tautomeric forms thereof, which is free or which is in the form of a metal alkoxide CTXOM, into contact with a heterocyclic side chain precursor having both a bifunctional protected (bidentate) and activated (acylating) form of an acid bearing a hydrogenated heteroatom, in the alpha (?) position with respect to the carboxyl group, and corresponding to the following general formula: in a customary aprotic solvent, preferably with a catalyst which may be a hindered tertiary amine, at a temperature of between ?80° C. and +100° C., preferably in the range 0 to 30° C.Type: ApplicationFiled: June 6, 2014Publication date: November 20, 2014Inventors: Jean-Pierre ROBIN, Nina RADOSEVIC, Julie BLANCHARD
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Patent number: 8816101Abstract: The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. The invention also relates to derivatives of lichesterinic acid of formula (A).Type: GrantFiled: March 4, 2011Date of Patent: August 26, 2014Assignees: Centre National de la Recherche Scientifique—CNRS, Universite de Rennes 1, Centre Hospitalier Universitaire PontchaillouInventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le-Devehat, Marylene Chollet-Krugler, Sophie Tomasi
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Publication number: 20140171498Abstract: This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from Leucas stelligera, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same.Type: ApplicationFiled: August 6, 2012Publication date: June 19, 2014Applicant: Council of Scientific & Indusrtial ReasearchInventors: Swati Joshi, Roshan Rajan Kulkarni, Ketaki Dilip Shurpali, Sampa Sarkar, Dhiman Sarkar
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Patent number: 8637684Abstract: The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.Type: GrantFiled: May 5, 2011Date of Patent: January 28, 2014Assignees: Wisconsin Alumni Research Foundation, Indiana University Research and Technology CorporationInventors: Ben Shen, Zhong-Yin Zhang
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Patent number: 8614211Abstract: Chemical entities that are arctigenin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.Type: GrantFiled: August 10, 2012Date of Patent: December 24, 2013Assignee: NeuPharma, Inc.Inventors: Xiangping Qian, Yong-Liang Zhu
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Publication number: 20130330457Abstract: A method of modifying the taste of a consumable, comprising adding to a consumable base at least one compound of the formula I in which (a) A is selected from the moieties (b) n is from 0-7, such that X is absent or a linear alkylene group in which n is from 1-7; and (c) Z is absent and Y is a moiety selected from the groups —CHO, or —CH2OH; or (d) Z is present and is a C1-7 linear alkane, and Y is selected from —CHOH, —CO, or —COC(CH3)O. The result is a consumable with enhanced mouthfeel and/or creaminess.Type: ApplicationFiled: March 12, 2013Publication date: December 12, 2013Applicant: GIVAUDAN S.A.Inventors: Jason JORDAN, David C. BOM, Philip A. CHRISTENSON, Robert G. EILERMAN, Xiaogen YANG
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Publication number: 20130330554Abstract: Insulating paint, containing a resin that can form an insulating film by application and baking, and a reducing agent having a boiling point of 160° C. or higher.Type: ApplicationFiled: August 15, 2013Publication date: December 12, 2013Applicants: Furukawa Magnet Wire Co., Ltd., Furukawa Electric Co., Ltd.Inventors: Makoto OYA, Makoto ONODERA, Keisuke IKEDA, Keiichi TOMIZAWA
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Patent number: 8580977Abstract: The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity.Type: GrantFiled: May 5, 2011Date of Patent: November 12, 2013Assignee: Wisconsin Alumni Research FoundationInventor: Ben Shen
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Publication number: 20130281381Abstract: Therapeutic compositions comprising at least one 8-substituted-dibenzylbutyrolactone lignan, preferably a lignan is selected from the group of nortrachelogenin, diasteromeric forms of nortrachelogenin, isomeric forms of nortrachelogenin and combinations thereof as well as 8-methylmatairesinol and 8-methyldimethylmatairesinol, for use in a method of treating cancer or a similar condition wherein the growth factor signaling pathway of a mammal is deregulated. The invention also provides therapeutic pharmaceutical combinations comprising a hydroxy-dibenzylbutyrolactone lignan and at least one TRAIL receptor agonist. The hydroxy-dibenzylbutyrolactone lignans and a TRAIL receptor agonist can be used as a combined preparation for administration to a patient simultaneously, separately or spaced out over a period of time in treating cancer.Type: ApplicationFiled: December 7, 2011Publication date: October 24, 2013Inventors: Emilia Peuhu, John Eriksson, Thomas Holmbom, Patrik Eklund, Rainer Sjoholm
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Patent number: 8541606Abstract: A polymer compound for a photoresist composition (a) having a high dissolution rate in a developing solution after exposure and (b) exhibiting little swelling during development. A tertiary alcohol derivative that is a raw material for the polymer compound. A tertiary alcohol that is an intermediate of the tertiary alcohol derivative. The tertiary alcohol is represented by formula (3): wherein R1 and R2 individually represent a linear, branched or cyclic alkylene group having 2 to 9 carbon atoms, which may contain an oxygen atom, and wherein R1 and R2 may together form a ring with a carbon atom to which R1 and R2 are bonded.Type: GrantFiled: December 16, 2011Date of Patent: September 24, 2013Assignee: Kuraray Co., Ltd.Inventors: Takashi Fukumoto, Ichihiro Aratani
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Patent number: 8535769Abstract: Since a polymerizable liquid crystal compound represented by the general formula (1) produces polymers exhibiting high optical anisotropy and high chemical resistance, and the optical anisotropy thereof exhibits low wavelength dependence, polymers obtained from a polymerizable liquid crystal composition comprising said polymerizable liquid crystal compound are useable as an optically anisotropic film for polarizers, wave plates, and the like, and are particularly best used in pattern formation that uses photolithography in air. (n represents an integer in the range of 3 to 10, m represents an integer in the range of 0 to 5, and q represents an integer in the range of 1 to 2.Type: GrantFiled: September 16, 2010Date of Patent: September 17, 2013Assignee: Nissan Chemical Industries, Ltd.Inventor: Daniel Antonio Sahade
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Publication number: 20130237596Abstract: The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity.Type: ApplicationFiled: October 19, 2011Publication date: September 12, 2013Applicant: ZHENGZHOU UNIVERSITYInventors: Guifu Dai, Haiwei Xu, Liping Zhu, Ruijing Dong, Fengjuan Wu, Yanan Wang, Zhiwen Jiang, Lijun Yan, Weiyi Li, Hongmin Liu
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Publication number: 20130217898Abstract: The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ?-caprolactone was obtained at an isolated yield of 82%.Type: ApplicationFiled: October 11, 2011Publication date: August 22, 2013Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITYInventors: Kazuaki Ishihara, Muhammet Uyanik
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Publication number: 20130040945Abstract: Chemical entities that are arctigenin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.Type: ApplicationFiled: August 10, 2012Publication date: February 14, 2013Inventors: Xiangping Qian, Yong-Liang Zhu
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Publication number: 20120329769Abstract: The present invention relates to compounds of formula (I) wherein Q is Q1 or Q2 P is P1, heterocyclylor heterocyclyl substituted by one to five Z; and wherein A1, A2, A3, A4, G1, Y1, Z, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (I) and to methods of using the compounds of formula (I) to control insect, acarine, nematode and mollusc pests.Type: ApplicationFiled: January 31, 2011Publication date: December 27, 2012Applicant: SYNGENTA CROP PROTECTION LLCInventors: Myriem El Qacemi, Jerome Yves Cassayre, Julie Clementine Toueg, Peter Renold, Thomas Pitterna
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Publication number: 20120329868Abstract: The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. The invention also relates to derivatives of lichesterinic acid of formula (A).Type: ApplicationFiled: March 4, 2011Publication date: December 27, 2012Applicants: Centre National de la Recherche Scientifique - CNRS, Centre Hospitalier Universitaire Pontchaillou, Universite de Rennes 1Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le-Devehat, Marylene Chollet-Krugler, Sophie Tomasi
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Publication number: 20120276546Abstract: A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2.Type: ApplicationFiled: June 21, 2012Publication date: November 1, 2012Applicant: Kao CorportationInventors: Hatsumi Souno, Hidetake Fujinaka, Junji Nakamura
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Publication number: 20120172560Abstract: Since a polymerizable liquid crystal compound represented by the general formula (1) produces polymers exhibiting high optical anisotropy and high chemical resistance, and the optical anisotropy thereof exhibits low wavelength dependence, polymers obtained from a polymerizable liquid crystal composition comprising said polymerizable liquid crystal compound are useable as an optically anisotropic film for polarizers, wave plates, and the like, and are particularly best used in pattern formation that uses photolithography in air. (n represents an integer in the range of 3 to 10, m represents an integer in the range of 0 to 5, and q represents an integer in the range of 1 to 2.Type: ApplicationFiled: September 16, 2010Publication date: July 5, 2012Inventor: Daniel Antonio Sahade
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Publication number: 20120157677Abstract: The present invention relates to lactone compounds represented by the following Formulas I and II, and methods of making such lactone compounds. The present invention also relates to methods of making other materials from such lactone compounds, such as fused ring indenol compounds (e.g., indeno-fused naphthols), and fused ring indenopyran compounds (e.g., indeno-fused naphthopyrans).Type: ApplicationFiled: December 7, 2011Publication date: June 21, 2012Applicant: TRANSITIONS OPTICAL INC.Inventors: Meng He, Darrin R. Dabideen, Ruisong Xu, Anil Kumar
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Publication number: 20120149921Abstract: A polymer compound for a photoresist composition (a) having a high dissolution rate in a developing solution after exposure and (b) exhibiting little swelling during development. A tertiary alcohol derivative that is a raw material for the polymer compound. A tertiary alcohol that is an intermediate of the tertiary alcohol derivative. The tertiary alcohol is represented by formula (3): wherein R1 and R2 individually represent a linear, branched or cyclic alkylene group having 2 to 9 carbon atoms, which may contain an oxygen atom, and wherein R1 and R2 may together form a ring with a carbon atom to which R1 and R2 are bonded.Type: ApplicationFiled: December 16, 2011Publication date: June 14, 2012Applicant: Kuraray Co., Ltd.Inventors: Takashi FUKUMOTO, Ichihiro Aratani
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Publication number: 20120121745Abstract: Compositions and methods for controlling Limnoperna sp., particularly, golden mussels are provided using Pseudomonas sp. suspension or compounds and compositions derived from said suspension.Type: ApplicationFiled: November 11, 2011Publication date: May 17, 2012Applicant: MARRONE BIO INNOVATIONS, INC.Inventors: Sarahann Rackl, Marja Koivunen, Pamela Marrone, Huazhang Huang, Ratnakar Asolkar
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Publication number: 20120015397Abstract: A marker for determining the onset of periodontal disease and a marker for determining the progression stage of periodontal disease, each containing autoinducer-2.Type: ApplicationFiled: April 15, 2010Publication date: January 19, 2012Applicant: Kao CorporationInventors: Hatsumi Souno, Hidetake Fujinaka, Junji Nakamura
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Publication number: 20120010282Abstract: The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity.Type: ApplicationFiled: May 5, 2011Publication date: January 12, 2012Applicant: Wisconsin Alumni Research FoundationInventor: Ben Shen
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Publication number: 20110300247Abstract: The invention relates compositions and methods for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans. Specifically, the invention relates to the dietary use of flaxseed lignans.Type: ApplicationFiled: April 11, 2011Publication date: December 8, 2011Inventor: Melpo CHRISTOFIDOU-SOLOMIDOU
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Publication number: 20110281942Abstract: The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.Type: ApplicationFiled: May 5, 2011Publication date: November 17, 2011Applicant: Wisconsin Alumni Research FoundationInventors: Ben Shen, Zhong-Yin Zhang
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Publication number: 20110185944Abstract: A novel chemical genus of furan-2-one antifouling compound as non-toxic, environment friendly antifouling agent, a coating material for objects submerged under the water based on the furan-2-one compounds. The substituted furan-2-one antifouling compounds have a furan-2-one ring and an alkyl side chain thereto and are of the formula: where n=6-14, representing the number of carbon atoms in said side chain.Type: ApplicationFiled: April 16, 2009Publication date: August 4, 2011Inventors: Peiyuan Qian, Ying Xu, Xiaojian Zhou, Hongping He, Nobuhiro Fusetani, Wei-Min Dai
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ANTI-CANCER ACTIVE SUBSTANCE FROM ANTRODIA CAMPHORATA, METHOD FOR PREPARING THE SAME AND USE THEREOF
Publication number: 20110123562Abstract: An anti-cancer active substance from Antrodia Camphorata, produced from mycelium of Antrodia Camphorata by following steps: (1) culturing mycelium of Antrodia Camphorata by liquid fermentation; (2) extracting the thus-obtained mycelium with ethanol and concentrating the extracted solution to obtain an ethanol extract; (3) dissolving the ethanol extract in water, and extracting with equal volume of ethyl acetate to obtain ethyl acetate extract; (4) purifying the ethyl acetate extract by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain an eluate fraction g; and (5) purifying the eluate fraction g by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain a specific eluate fraction which could be purified further to obtain the anti-cancer active substance from Antrodia Camphorata.Type: ApplicationFiled: November 24, 2010Publication date: May 26, 2011Inventors: Been-Huang CHIANG, Yu-Wei LIN -
Patent number: 7915429Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula (Type: GrantFiled: January 22, 2007Date of Patent: March 29, 2011Assignee: Wellstat Therapeutics CorporationInventors: Shalini Sharma, Reid W. von Borstel
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Patent number: 7862867Abstract: Disclosed is a bifunctional polymerizable compound represented by the formula [1]. Also disclosed is a polymerizable liquid crystal composition comprising at least one bifunctional polymerizable compound represented by the formula [1] and a polymerizable liquid crystal compound. The bifunctional polymerizable compound has a high polymerizability. When added to a polymerizable liquid crystal compound to prepare a polymerizable liquid crystal composition, the bifunctional polymerizable compound enables to remarkably improve the thermal stability of a polymer produced from the composition. The polymerizable liquid crystal composition containing the bifunctional polymerizable compound has a low crystallization temperature and shows a stable liquid-crystallinity under ordinary environment wherein X1, X2 and X3 independently represent a single bond or a benzene ring; Y represents —O— or a single bond; M represents a lactone ring or an acrylate group; and n represents an integer of 4 to 10.Type: GrantFiled: October 2, 2007Date of Patent: January 4, 2011Assignee: Nissan Chemical Industries, Ltd.Inventor: Daniel Antonio Sahade
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Publication number: 20100286262Abstract: It has been demonstrated that a group of single nucleotide polymorphisms can be used to determine the presence or absence of certain extended PTGS2 haplotypes in the genome of a subject or individual, in order to determine the susceptibility to disease of the subject, the disease prognosis of the subject, or predict the response to therapy of the subject, thereby allowing personalised therapy of said subject.Type: ApplicationFiled: October 9, 2008Publication date: November 11, 2010Inventor: Xiao-He Chen
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Publication number: 20100286414Abstract: Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.Type: ApplicationFiled: July 20, 2010Publication date: November 11, 2010Inventors: Tushar K. Bera, Jacob Emert, Jun Hua
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Patent number: 7824839Abstract: The invention provides various ionic and non-ionic photoacid generator compounds. Photoresist compositions that include the novel ionic and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for various microfabrication applications.Type: GrantFiled: October 21, 2008Date of Patent: November 2, 2010Assignee: Cornell Research Foundation, Inc.Inventors: Christopher K. Ober, Yi Yi, Ramakrishnan Ayothi
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Publication number: 20100167200Abstract: A (meth)acrylate compound having an acid-labile ester group, a photosensitive polymer, and a resist composition including the same, the (meth)acrylate compound being represented by the following Chemical Formula 1 wherein, R1 is hydrogen or methyl, R2 and R3 are each independently a substituted or unsubstituted linear alkyl, a substituted or unsubstituted cyclic alkyl, or linked each other to form a monocyclic ring or a fused-ring, and R4 is a linear ester or cyclic ester group.Type: ApplicationFiled: December 30, 2009Publication date: July 1, 2010Inventors: Sang-Jun Choi, Sung-Jae Lee, Seung-Jib Choi
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Patent number: 7745647Abstract: The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof. The present invention also relates to a pharmaceutical composition containing at least one of the novel diterpene compounds, and a use of the diterpene compound as a neuroprotective agent.Type: GrantFiled: December 24, 2008Date of Patent: June 29, 2010Assignee: Kang Jian Biotech Corp, Ltd.Inventors: Min-Nan Lai, Yueh-Hsiung Kuo, Young-Ji Shiao
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Publication number: 20100159540Abstract: Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ?-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.Type: ApplicationFiled: March 26, 2008Publication date: June 24, 2010Inventors: Ana Rodriguez, Bernd Spur
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Publication number: 20100137595Abstract: Use vaginal odorant compounds for controlling motile cell chemotaxis.Type: ApplicationFiled: June 27, 2008Publication date: June 3, 2010Applicant: Fraunhofer-Gesellshcaft zur Forderung der angewandten Forschung e.V.Inventor: Andrea Büttner
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Publication number: 20100048545Abstract: The invention relates to 4-hydroxyisoleucine, isomers, analogs, lactones, salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. More particularly, the invention relates to the use of those compounds in the prevention and treatment of disorders of fat metabolism and related syndromes. The invention further relates to the use of those compounds in the prevention and treatment of obesity and related syndromes including, but not limited to, the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight, and more particularly loss of body fat.Type: ApplicationFiled: March 22, 2007Publication date: February 25, 2010Applicant: INNODIA INC.Inventors: Lucie Jette, Patricia Mcnicol, Manjinder Gill, André Marette
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Patent number: 7601854Abstract: The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof. The present invention also relates to a pharmaceutical composition containing at least one of the novel diterpene compounds, and a use of the diterpene compound as a neuroprotective agent.Type: GrantFiled: October 25, 2006Date of Patent: October 13, 2009Assignee: Kang Jian Biotech Corp., Ltd.Inventors: Min-Nan Lai, Yueh-Hsiung Kuo, Young-Ji Shiao
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Publication number: 20090149531Abstract: The present invention is a chemical composition including: Use of the compound with the chemical formula can be applied in pharmaceutical compositions for the treatment of psoriasis.Type: ApplicationFiled: December 10, 2008Publication date: June 11, 2009Applicant: APOTEKNOS PARA LA PIEL, S.L.Inventors: Juan Pablo PIVEL RANIERI, Juan Manuel Ferrer Cuesta, Fernando Martinez Galan, Juan Manuel Irache, Jose Luis Novella Robisco, Juan Jose Perez Rueda, Ma Paz Maria Martin, Julio Alvarez-Builla Gomez, Jaime Bermejo, Fernando Vidal Vanaclocha
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Publication number: 20090136868Abstract: The invention provides various ionic and non-ionic photoacid generator compounds. Photoresist compositions that include the novel ionic and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for various microfabrication applications.Type: ApplicationFiled: October 21, 2008Publication date: May 28, 2009Inventors: Christopher K. Ober, Yi Yi, Ramakrishnan Ayothi
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Publication number: 20090118364Abstract: The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorate, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof. The present invention also relates to a pharmaceutical composition containing at least one of the novel diterpene compounds, and a use of the diterpene compound as a neuroprotective agent.Type: ApplicationFiled: December 24, 2008Publication date: May 7, 2009Inventors: Min-Nan Lai, Yueh-Hsiung Kuo, Young-Ji Shiao
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Patent number: 7528166Abstract: Novel phenolic esters of lignans, and pharmaceutical compositions, dietary supplements, and food products containing these esters.Type: GrantFiled: January 21, 2003Date of Patent: May 5, 2009Assignee: Hormos Medical CorporationInventors: Patrik Eklund, Mervi Hiilovaara-Teijo, Arja Kalapudas, Lauri Kangas, Anna Lindholm, Rainer Sjohölm, Marja Södervall, Mikko Unkila
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Publication number: 20090088545Abstract: This invention provides a polymerizable liquid crystal compound having an ?-methylene-?-butyrolactone site (for example, a polymerizable liquid crystal compound represented by formula (Z2)) useful as a material for optically anisotropic films such as optical compensation films and multidomain films, for example, in polarizing plates and phase difference plates for use in display devices such as liquid crystal display devices, and a polymerizable liquid crystal composition using the same, and their polymer and film.Type: ApplicationFiled: April 18, 2006Publication date: April 2, 2009Inventors: Daniel Antonio Sahade, Takuro Oda
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Patent number: 7511160Abstract: A lactone derivative that is expressed by the following formula (I).Type: GrantFiled: September 14, 2005Date of Patent: March 31, 2009Assignees: Toyota Jidosha Kabushiki Kaisha, Genesis Research Institute, Inc.Inventors: Masayuki Kamiya, Kiyohiko Tajima, Eiji Furuya, Hideo Hattori
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Publication number: 20090029290Abstract: (1) A polymer compound for photoresist composition which is high in dissolution rate in a developing solution after exposure and small swelling at the development and (2) a compound which is a raw material for such a polymer compound are provided. Furthermore, (3) a photoresist composition containing the subject polymer compound is provided. In detail, a tertiary alcohol derivative represented by the following general formula (1) is provided. (In the formula, R1 and R2 are taken together to form a ring together with a carbon atom to which R1 and R2 are bonded, and R1 and R2 as taken represent a linear, branched or cyclic alkylene group having from 2 to 9 carbon atoms, which may contain an oxygen atom at an arbitrary position; R3 represents a hydrogen atom or a methyl group; w represents a linear, branched or cyclic alkylene group having from 1 to 10 carbon atoms; and n represents 0 or 1.Type: ApplicationFiled: February 16, 2007Publication date: January 29, 2009Applicant: KURARAY CO., LTD.Inventors: Takashi Fukumoto, Ichihiro Aratani