Chalcogen Attached Indirectly To The Lactone Ring By Nonionic Bonding Patents (Class 549/323)
  • Patent number: 10858307
    Abstract: Provided herein are compositions and methods of treating liver cancer by novel anticancer agents.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: December 8, 2020
    Assignee: Golden Biotechnology Corporation
    Inventors: Sheng-Yung Liu, Chih-Ming Chen
  • Patent number: 9139789
    Abstract: A method for producing a petroleum substitute through a solvent extraction of woody tree material is provided. A raw biomass of woody tree material is processed into solvent-permeable wood particles and chips. Naturally occurring hydrocarbons suitable for use as a petroleum substitute are extracted by a mixture of polar and non-polar organic solvents in a counterflow operation. The extracted hydrocarbon oils are then separated from the solvent for use as a petroleum substitute, while the solvent is reused in the extraction process.
    Type: Grant
    Filed: June 4, 2011
    Date of Patent: September 22, 2015
    Assignee: Phytoleum Technologies Group, LLC
    Inventor: Stephen Daniel Matthews
  • Publication number: 20150093345
    Abstract: An arctigenin derivative used for anti-aging treatment, including protection of the skin from the sun and recovery of skin elasticity. A variety of fatty acid ester derivatives, alcohol ether derivatives and alkylated derivatives are used as the arctigenin derivatives. Agents for controlling ET-1 production, elastase inhibitors, and anti-inflammatory agents are prepared. Such arctigenin derivatives are particularly useful as an external agent for the skin, such as an anti-inflammatory external agent, a sunscreen external agent, or an external agent for recovering elasticity.
    Type: Application
    Filed: March 27, 2013
    Publication date: April 2, 2015
    Inventors: Yuya Hayashi, Yoko Mizutare
  • Publication number: 20150030577
    Abstract: Provided are compounds and compositions derived from Pseudomonas sp., particularly, Pseudomonas fluorescens or Pseudomonas protegens and more particularly strain having the identifying characteristics of Pseudomonas ATCC 55799 having antimicrobial properties and particularly, antibacterial properties.
    Type: Application
    Filed: February 27, 2013
    Publication date: January 29, 2015
    Applicant: Marrone Bio Innovations, Inc.
    Inventors: Ratnakar Asolkar, Ana Lucia Cordova-Kreylos, Carly Todd
  • Publication number: 20150018567
    Abstract: Provided herein are processes of preparing cyclohexenone compounds useful for cancer treatments and/or diseases.
    Type: Application
    Filed: February 20, 2014
    Publication date: January 15, 2015
    Applicant: Golden Biotechnology Corporation
    Inventors: Sheng-Yung Liu, Wu-Che Wen, Chih-Ming Chen, Hsiu-Yi Cheng
  • Publication number: 20140343039
    Abstract: There is provided a process for preparing cephalotaxine esters corresponding to the following general formula I, which comprises the cephalotaxine backbone, and that can be written as C(R1)(R2)(XH)COO[CTX], wherein CTX represents the cephalotaxine backbone, being optionally substituted, the process consisting in bringing the corresponding cephalotaxine compound, or salts, isomers or tautomeric forms thereof, which is free or which is in the form of a metal alkoxide CTXOM, into contact with a heterocyclic side chain precursor having both a bifunctional protected (bidentate) and activated (acylating) form of an acid bearing a hydrogenated heteroatom, in the alpha (?) position with respect to the carboxyl group, and corresponding to the following general formula: in a customary aprotic solvent, preferably with a catalyst which may be a hindered tertiary amine, at a temperature of between ?80° C. and +100° C., preferably in the range 0 to 30° C.
    Type: Application
    Filed: June 6, 2014
    Publication date: November 20, 2014
    Inventors: Jean-Pierre ROBIN, Nina RADOSEVIC, Julie BLANCHARD
  • Patent number: 8816101
    Abstract: The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. The invention also relates to derivatives of lichesterinic acid of formula (A).
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: August 26, 2014
    Assignees: Centre National de la Recherche Scientifique—CNRS, Universite de Rennes 1, Centre Hospitalier Universitaire Pontchaillou
    Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le-Devehat, Marylene Chollet-Krugler, Sophie Tomasi
  • Publication number: 20140171498
    Abstract: This invention relates to diterpenes of general formula (1) belonging to labdane class, isolated from Leucas stelligera, being useful for prevention, treatment, inhibition or controlling growth and proliferation of mycobacterial activity in mammals. The invention further discloses process for isolation of the fractions containing the same.
    Type: Application
    Filed: August 6, 2012
    Publication date: June 19, 2014
    Applicant: Council of Scientific & Indusrtial Reasearch
    Inventors: Swati Joshi, Roshan Rajan Kulkarni, Ketaki Dilip Shurpali, Sampa Sarkar, Dhiman Sarkar
  • Patent number: 8637684
    Abstract: The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: January 28, 2014
    Assignees: Wisconsin Alumni Research Foundation, Indiana University Research and Technology Corporation
    Inventors: Ben Shen, Zhong-Yin Zhang
  • Patent number: 8614211
    Abstract: Chemical entities that are arctigenin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: December 24, 2013
    Assignee: NeuPharma, Inc.
    Inventors: Xiangping Qian, Yong-Liang Zhu
  • Publication number: 20130330457
    Abstract: A method of modifying the taste of a consumable, comprising adding to a consumable base at least one compound of the formula I in which (a) A is selected from the moieties (b) n is from 0-7, such that X is absent or a linear alkylene group in which n is from 1-7; and (c) Z is absent and Y is a moiety selected from the groups —CHO, or —CH2OH; or (d) Z is present and is a C1-7 linear alkane, and Y is selected from —CHOH, —CO, or —COC(CH3)O. The result is a consumable with enhanced mouthfeel and/or creaminess.
    Type: Application
    Filed: March 12, 2013
    Publication date: December 12, 2013
    Applicant: GIVAUDAN S.A.
    Inventors: Jason JORDAN, David C. BOM, Philip A. CHRISTENSON, Robert G. EILERMAN, Xiaogen YANG
  • Publication number: 20130330554
    Abstract: Insulating paint, containing a resin that can form an insulating film by application and baking, and a reducing agent having a boiling point of 160° C. or higher.
    Type: Application
    Filed: August 15, 2013
    Publication date: December 12, 2013
    Applicants: Furukawa Magnet Wire Co., Ltd., Furukawa Electric Co., Ltd.
    Inventors: Makoto OYA, Makoto ONODERA, Keisuke IKEDA, Keiichi TOMIZAWA
  • Patent number: 8580977
    Abstract: The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity.
    Type: Grant
    Filed: May 5, 2011
    Date of Patent: November 12, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Ben Shen
  • Publication number: 20130281381
    Abstract: Therapeutic compositions comprising at least one 8-substituted-dibenzylbutyrolactone lignan, preferably a lignan is selected from the group of nortrachelogenin, diasteromeric forms of nortrachelogenin, isomeric forms of nortrachelogenin and combinations thereof as well as 8-methylmatairesinol and 8-methyldimethylmatairesinol, for use in a method of treating cancer or a similar condition wherein the growth factor signaling pathway of a mammal is deregulated. The invention also provides therapeutic pharmaceutical combinations comprising a hydroxy-dibenzylbutyrolactone lignan and at least one TRAIL receptor agonist. The hydroxy-dibenzylbutyrolactone lignans and a TRAIL receptor agonist can be used as a combined preparation for administration to a patient simultaneously, separately or spaced out over a period of time in treating cancer.
    Type: Application
    Filed: December 7, 2011
    Publication date: October 24, 2013
    Inventors: Emilia Peuhu, John Eriksson, Thomas Holmbom, Patrik Eklund, Rainer Sjoholm
  • Patent number: 8541606
    Abstract: A polymer compound for a photoresist composition (a) having a high dissolution rate in a developing solution after exposure and (b) exhibiting little swelling during development. A tertiary alcohol derivative that is a raw material for the polymer compound. A tertiary alcohol that is an intermediate of the tertiary alcohol derivative. The tertiary alcohol is represented by formula (3): wherein R1 and R2 individually represent a linear, branched or cyclic alkylene group having 2 to 9 carbon atoms, which may contain an oxygen atom, and wherein R1 and R2 may together form a ring with a carbon atom to which R1 and R2 are bonded.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: September 24, 2013
    Assignee: Kuraray Co., Ltd.
    Inventors: Takashi Fukumoto, Ichihiro Aratani
  • Patent number: 8535769
    Abstract: Since a polymerizable liquid crystal compound represented by the general formula (1) produces polymers exhibiting high optical anisotropy and high chemical resistance, and the optical anisotropy thereof exhibits low wavelength dependence, polymers obtained from a polymerizable liquid crystal composition comprising said polymerizable liquid crystal compound are useable as an optically anisotropic film for polarizers, wave plates, and the like, and are particularly best used in pattern formation that uses photolithography in air. (n represents an integer in the range of 3 to 10, m represents an integer in the range of 0 to 5, and q represents an integer in the range of 1 to 2.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: September 17, 2013
    Assignee: Nissan Chemical Industries, Ltd.
    Inventor: Daniel Antonio Sahade
  • Publication number: 20130237596
    Abstract: The present invention relates to the preparation of anti-tumor drugs with andrographolide derivatives, which belongs to the field of pharmaceutical technology, and involves 15-benzylidene substituted derivatives of 14-deoxy-11,12-didehydro-andrographolide and their 3,19-ester derivatives. Proved by the experiments, these compounds significantly inhibited the colony formation and migration ability of various cancer cells, and also inhibited the migration ability of vascular endothelial cells in vitro. The compounds of this invention significantly inhibited the tumor growth, invasion, metastasis and angiogenesis on mouse xenograft models, and inhibited the experimental lung metastasis of B16-F10 malignant melanoma cells. Therefore, this class of compounds could be used as the active ingredients for the preparation of antineoplastic drugs, which are of efficiency and low-toxicity.
    Type: Application
    Filed: October 19, 2011
    Publication date: September 12, 2013
    Applicant: ZHENGZHOU UNIVERSITY
    Inventors: Guifu Dai, Haiwei Xu, Liping Zhu, Ruijing Dong, Fengjuan Wu, Yanan Wang, Zhiwen Jiang, Lijun Yan, Weiyi Li, Hongmin Liu
  • Publication number: 20130217898
    Abstract: The present invention relates to a method for manufacturing an ester from a ketone or an aldehyde, which is a reactive substrate, by a Baeyer-Villiger oxidation reaction using hydrogen peroxide, and in this method, as a catalyst, M(BAr4)n, which is a metal borate, is used (M represents an alkali metal or an alkaline earth metal; Ar represents an aryl; and n is the same number as the valence of M). For example, when cyclohexanone was used as the reactive substrate, and Sr[B(3,5-CF3C6H3)4]2 was used as the catalyst, ?-caprolactone was obtained at an isolated yield of 82%.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 22, 2013
    Applicant: NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY
    Inventors: Kazuaki Ishihara, Muhammet Uyanik
  • Publication number: 20130040945
    Abstract: Chemical entities that are arctigenin derivatives, pharmaceutical compositions and methods of treatment of cancer are described.
    Type: Application
    Filed: August 10, 2012
    Publication date: February 14, 2013
    Inventors: Xiangping Qian, Yong-Liang Zhu
  • Publication number: 20120329769
    Abstract: The present invention relates to compounds of formula (I) wherein Q is Q1 or Q2 P is P1, heterocyclylor heterocyclyl substituted by one to five Z; and wherein A1, A2, A3, A4, G1, Y1, Z, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (I) and to methods of using the compounds of formula (I) to control insect, acarine, nematode and mollusc pests.
    Type: Application
    Filed: January 31, 2011
    Publication date: December 27, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Myriem El Qacemi, Jerome Yves Cassayre, Julie Clementine Toueg, Peter Renold, Thomas Pitterna
  • Publication number: 20120329868
    Abstract: The invention relates to a mixture comprising protolichesterinic acid or a salt thereof or a diastereoisomer thereof or a derivative thereof, and lichesterinic acid or a salt thereof or an enantiomer thereof or a derivative thereof, for use for stimulating pigmentation of the skin and/or of its appendages. The invention also relates to derivatives of lichesterinic acid of formula (A).
    Type: Application
    Filed: March 4, 2011
    Publication date: December 27, 2012
    Applicants: Centre National de la Recherche Scientifique - CNRS, Centre Hospitalier Universitaire Pontchaillou, Universite de Rennes 1
    Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le-Devehat, Marylene Chollet-Krugler, Sophie Tomasi
  • Publication number: 20120276546
    Abstract: A marker for determining the onset of periodontal disease and a marker far determining the progression stage of periodontal disease, each containing autoinducer-2.
    Type: Application
    Filed: June 21, 2012
    Publication date: November 1, 2012
    Applicant: Kao Corportation
    Inventors: Hatsumi Souno, Hidetake Fujinaka, Junji Nakamura
  • Publication number: 20120172560
    Abstract: Since a polymerizable liquid crystal compound represented by the general formula (1) produces polymers exhibiting high optical anisotropy and high chemical resistance, and the optical anisotropy thereof exhibits low wavelength dependence, polymers obtained from a polymerizable liquid crystal composition comprising said polymerizable liquid crystal compound are useable as an optically anisotropic film for polarizers, wave plates, and the like, and are particularly best used in pattern formation that uses photolithography in air. (n represents an integer in the range of 3 to 10, m represents an integer in the range of 0 to 5, and q represents an integer in the range of 1 to 2.
    Type: Application
    Filed: September 16, 2010
    Publication date: July 5, 2012
    Inventor: Daniel Antonio Sahade
  • Publication number: 20120157677
    Abstract: The present invention relates to lactone compounds represented by the following Formulas I and II, and methods of making such lactone compounds. The present invention also relates to methods of making other materials from such lactone compounds, such as fused ring indenol compounds (e.g., indeno-fused naphthols), and fused ring indenopyran compounds (e.g., indeno-fused naphthopyrans).
    Type: Application
    Filed: December 7, 2011
    Publication date: June 21, 2012
    Applicant: TRANSITIONS OPTICAL INC.
    Inventors: Meng He, Darrin R. Dabideen, Ruisong Xu, Anil Kumar
  • Publication number: 20120149921
    Abstract: A polymer compound for a photoresist composition (a) having a high dissolution rate in a developing solution after exposure and (b) exhibiting little swelling during development. A tertiary alcohol derivative that is a raw material for the polymer compound. A tertiary alcohol that is an intermediate of the tertiary alcohol derivative. The tertiary alcohol is represented by formula (3): wherein R1 and R2 individually represent a linear, branched or cyclic alkylene group having 2 to 9 carbon atoms, which may contain an oxygen atom, and wherein R1 and R2 may together form a ring with a carbon atom to which R1 and R2 are bonded.
    Type: Application
    Filed: December 16, 2011
    Publication date: June 14, 2012
    Applicant: Kuraray Co., Ltd.
    Inventors: Takashi FUKUMOTO, Ichihiro Aratani
  • Publication number: 20120121745
    Abstract: Compositions and methods for controlling Limnoperna sp., particularly, golden mussels are provided using Pseudomonas sp. suspension or compounds and compositions derived from said suspension.
    Type: Application
    Filed: November 11, 2011
    Publication date: May 17, 2012
    Applicant: MARRONE BIO INNOVATIONS, INC.
    Inventors: Sarahann Rackl, Marja Koivunen, Pamela Marrone, Huazhang Huang, Ratnakar Asolkar
  • Publication number: 20120015397
    Abstract: A marker for determining the onset of periodontal disease and a marker for determining the progression stage of periodontal disease, each containing autoinducer-2.
    Type: Application
    Filed: April 15, 2010
    Publication date: January 19, 2012
    Applicant: Kao Corporation
    Inventors: Hatsumi Souno, Hidetake Fujinaka, Junji Nakamura
  • Publication number: 20120010282
    Abstract: The present invention relates to the biosynthetic gene cluster for tautomycetin (TTN) produces tautomycetin. Also provided are engineered micro-organisms for the production of TTN and analogs thereof, as well as methods of screening for compounds for activity.
    Type: Application
    Filed: May 5, 2011
    Publication date: January 12, 2012
    Applicant: Wisconsin Alumni Research Foundation
    Inventor: Ben Shen
  • Publication number: 20110300247
    Abstract: The invention relates compositions and methods for treating pathological lung conditions using whole-grain flaxseed or flaxseed lignans. Specifically, the invention relates to the dietary use of flaxseed lignans.
    Type: Application
    Filed: April 11, 2011
    Publication date: December 8, 2011
    Inventor: Melpo CHRISTOFIDOU-SOLOMIDOU
  • Publication number: 20110281942
    Abstract: The present invention relates to tautomycetin (TTN) and analogs thereof. Also provided are methods of using TTN and analogs thereof in the treatment of various diseases relating to SHP2 function.
    Type: Application
    Filed: May 5, 2011
    Publication date: November 17, 2011
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Ben Shen, Zhong-Yin Zhang
  • Publication number: 20110185944
    Abstract: A novel chemical genus of furan-2-one antifouling compound as non-toxic, environment friendly antifouling agent, a coating material for objects submerged under the water based on the furan-2-one compounds. The substituted furan-2-one antifouling compounds have a furan-2-one ring and an alkyl side chain thereto and are of the formula: where n=6-14, representing the number of carbon atoms in said side chain.
    Type: Application
    Filed: April 16, 2009
    Publication date: August 4, 2011
    Inventors: Peiyuan Qian, Ying Xu, Xiaojian Zhou, Hongping He, Nobuhiro Fusetani, Wei-Min Dai
  • Publication number: 20110123562
    Abstract: An anti-cancer active substance from Antrodia Camphorata, produced from mycelium of Antrodia Camphorata by following steps: (1) culturing mycelium of Antrodia Camphorata by liquid fermentation; (2) extracting the thus-obtained mycelium with ethanol and concentrating the extracted solution to obtain an ethanol extract; (3) dissolving the ethanol extract in water, and extracting with equal volume of ethyl acetate to obtain ethyl acetate extract; (4) purifying the ethyl acetate extract by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain an eluate fraction g; and (5) purifying the eluate fraction g by silica gel column chromatography using hexane/ethyl acetate gradient as the mobile phase to obtain a specific eluate fraction which could be purified further to obtain the anti-cancer active substance from Antrodia Camphorata.
    Type: Application
    Filed: November 24, 2010
    Publication date: May 26, 2011
    Inventors: Been-Huang CHIANG, Yu-Wei LIN
  • Patent number: 7915429
    Abstract: Agents useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, polycystic ovary syndrome, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis are disclosed, wherein n is 1 or 2; m is 0, 1, 2, 3 or 4; q is 0 or 1; t is 0 or 1; R1 is alkyl having from 1 to 3 carbon atoms; R2 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms, or alkoxy having from 1 to 3 carbon atoms; A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from: halo, hydroxy, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy; or cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula (
    Type: Grant
    Filed: January 22, 2007
    Date of Patent: March 29, 2011
    Assignee: Wellstat Therapeutics Corporation
    Inventors: Shalini Sharma, Reid W. von Borstel
  • Patent number: 7862867
    Abstract: Disclosed is a bifunctional polymerizable compound represented by the formula [1]. Also disclosed is a polymerizable liquid crystal composition comprising at least one bifunctional polymerizable compound represented by the formula [1] and a polymerizable liquid crystal compound. The bifunctional polymerizable compound has a high polymerizability. When added to a polymerizable liquid crystal compound to prepare a polymerizable liquid crystal composition, the bifunctional polymerizable compound enables to remarkably improve the thermal stability of a polymer produced from the composition. The polymerizable liquid crystal composition containing the bifunctional polymerizable compound has a low crystallization temperature and shows a stable liquid-crystallinity under ordinary environment wherein X1, X2 and X3 independently represent a single bond or a benzene ring; Y represents —O— or a single bond; M represents a lactone ring or an acrylate group; and n represents an integer of 4 to 10.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: January 4, 2011
    Assignee: Nissan Chemical Industries, Ltd.
    Inventor: Daniel Antonio Sahade
  • Publication number: 20100286262
    Abstract: It has been demonstrated that a group of single nucleotide polymorphisms can be used to determine the presence or absence of certain extended PTGS2 haplotypes in the genome of a subject or individual, in order to determine the susceptibility to disease of the subject, the disease prognosis of the subject, or predict the response to therapy of the subject, thereby allowing personalised therapy of said subject.
    Type: Application
    Filed: October 9, 2008
    Publication date: November 11, 2010
    Inventor: Xiao-He Chen
  • Publication number: 20100286414
    Abstract: Linked aromatic compounds found to act as potent soot dispersants in lubricating oil compositions; lubricating oil compositions containing such soot dispersants and precursor compounds from which the soot dispersants are derived.
    Type: Application
    Filed: July 20, 2010
    Publication date: November 11, 2010
    Inventors: Tushar K. Bera, Jacob Emert, Jun Hua
  • Patent number: 7824839
    Abstract: The invention provides various ionic and non-ionic photoacid generator compounds. Photoresist compositions that include the novel ionic and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for various microfabrication applications.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: November 2, 2010
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Christopher K. Ober, Yi Yi, Ramakrishnan Ayothi
  • Publication number: 20100167200
    Abstract: A (meth)acrylate compound having an acid-labile ester group, a photosensitive polymer, and a resist composition including the same, the (meth)acrylate compound being represented by the following Chemical Formula 1 wherein, R1 is hydrogen or methyl, R2 and R3 are each independently a substituted or unsubstituted linear alkyl, a substituted or unsubstituted cyclic alkyl, or linked each other to form a monocyclic ring or a fused-ring, and R4 is a linear ester or cyclic ester group.
    Type: Application
    Filed: December 30, 2009
    Publication date: July 1, 2010
    Inventors: Sang-Jun Choi, Sung-Jae Lee, Seung-Jib Choi
  • Patent number: 7745647
    Abstract: The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof. The present invention also relates to a pharmaceutical composition containing at least one of the novel diterpene compounds, and a use of the diterpene compound as a neuroprotective agent.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: June 29, 2010
    Assignee: Kang Jian Biotech Corp, Ltd.
    Inventors: Min-Nan Lai, Yueh-Hsiung Kuo, Young-Ji Shiao
  • Publication number: 20100159540
    Abstract: Methods are disclosed for the preparation of a new class of lipid mediators known as resolvins, with Resolvin D6 (4,17-dihydroxy-5E,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid) being exemplary. Also disclosed are methods for the efficient synthesis of key intermediates in the preparation of such resolvins, such as isotopically labeled ?-3 fatty acid metabolites, and derivatives and analogs thereof. The invention likewise extends to the intermediates so prepared, and to the resolvins prepared with their use.
    Type: Application
    Filed: March 26, 2008
    Publication date: June 24, 2010
    Inventors: Ana Rodriguez, Bernd Spur
  • Publication number: 20100137595
    Abstract: Use vaginal odorant compounds for controlling motile cell chemotaxis.
    Type: Application
    Filed: June 27, 2008
    Publication date: June 3, 2010
    Applicant: Fraunhofer-Gesellshcaft zur Forderung der angewandten Forschung e.V.
    Inventor: Andrea Büttner
  • Publication number: 20100048545
    Abstract: The invention relates to 4-hydroxyisoleucine, isomers, analogs, lactones, salts, and prodrugs thereof, to processes for their preparation, and to pharmaceutical compositions comprising the same. More particularly, the invention relates to the use of those compounds in the prevention and treatment of disorders of fat metabolism and related syndromes. The invention further relates to the use of those compounds in the prevention and treatment of obesity and related syndromes including, but not limited to, the cosmetic treatment of a mammal in order to effect a cosmetically beneficial loss of body weight, and more particularly loss of body fat.
    Type: Application
    Filed: March 22, 2007
    Publication date: February 25, 2010
    Applicant: INNODIA INC.
    Inventors: Lucie Jette, Patricia Mcnicol, Manjinder Gill, André Marette
  • Patent number: 7601854
    Abstract: The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof. The present invention also relates to a pharmaceutical composition containing at least one of the novel diterpene compounds, and a use of the diterpene compound as a neuroprotective agent.
    Type: Grant
    Filed: October 25, 2006
    Date of Patent: October 13, 2009
    Assignee: Kang Jian Biotech Corp., Ltd.
    Inventors: Min-Nan Lai, Yueh-Hsiung Kuo, Young-Ji Shiao
  • Publication number: 20090149531
    Abstract: The present invention is a chemical composition including: Use of the compound with the chemical formula can be applied in pharmaceutical compositions for the treatment of psoriasis.
    Type: Application
    Filed: December 10, 2008
    Publication date: June 11, 2009
    Applicant: APOTEKNOS PARA LA PIEL, S.L.
    Inventors: Juan Pablo PIVEL RANIERI, Juan Manuel Ferrer Cuesta, Fernando Martinez Galan, Juan Manuel Irache, Jose Luis Novella Robisco, Juan Jose Perez Rueda, Ma Paz Maria Martin, Julio Alvarez-Builla Gomez, Jaime Bermejo, Fernando Vidal Vanaclocha
  • Publication number: 20090136868
    Abstract: The invention provides various ionic and non-ionic photoacid generator compounds. Photoresist compositions that include the novel ionic and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for various microfabrication applications.
    Type: Application
    Filed: October 21, 2008
    Publication date: May 28, 2009
    Inventors: Christopher K. Ober, Yi Yi, Ramakrishnan Ayothi
  • Publication number: 20090118364
    Abstract: The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorate, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof. The present invention also relates to a pharmaceutical composition containing at least one of the novel diterpene compounds, and a use of the diterpene compound as a neuroprotective agent.
    Type: Application
    Filed: December 24, 2008
    Publication date: May 7, 2009
    Inventors: Min-Nan Lai, Yueh-Hsiung Kuo, Young-Ji Shiao
  • Patent number: 7528166
    Abstract: Novel phenolic esters of lignans, and pharmaceutical compositions, dietary supplements, and food products containing these esters.
    Type: Grant
    Filed: January 21, 2003
    Date of Patent: May 5, 2009
    Assignee: Hormos Medical Corporation
    Inventors: Patrik Eklund, Mervi Hiilovaara-Teijo, Arja Kalapudas, Lauri Kangas, Anna Lindholm, Rainer Sjohölm, Marja Södervall, Mikko Unkila
  • Publication number: 20090088545
    Abstract: This invention provides a polymerizable liquid crystal compound having an ?-methylene-?-butyrolactone site (for example, a polymerizable liquid crystal compound represented by formula (Z2)) useful as a material for optically anisotropic films such as optical compensation films and multidomain films, for example, in polarizing plates and phase difference plates for use in display devices such as liquid crystal display devices, and a polymerizable liquid crystal composition using the same, and their polymer and film.
    Type: Application
    Filed: April 18, 2006
    Publication date: April 2, 2009
    Inventors: Daniel Antonio Sahade, Takuro Oda
  • Patent number: 7511160
    Abstract: A lactone derivative that is expressed by the following formula (I).
    Type: Grant
    Filed: September 14, 2005
    Date of Patent: March 31, 2009
    Assignees: Toyota Jidosha Kabushiki Kaisha, Genesis Research Institute, Inc.
    Inventors: Masayuki Kamiya, Kiyohiko Tajima, Eiji Furuya, Hideo Hattori
  • Publication number: 20090029290
    Abstract: (1) A polymer compound for photoresist composition which is high in dissolution rate in a developing solution after exposure and small swelling at the development and (2) a compound which is a raw material for such a polymer compound are provided. Furthermore, (3) a photoresist composition containing the subject polymer compound is provided. In detail, a tertiary alcohol derivative represented by the following general formula (1) is provided. (In the formula, R1 and R2 are taken together to form a ring together with a carbon atom to which R1 and R2 are bonded, and R1 and R2 as taken represent a linear, branched or cyclic alkylene group having from 2 to 9 carbon atoms, which may contain an oxygen atom at an arbitrary position; R3 represents a hydrogen atom or a methyl group; w represents a linear, branched or cyclic alkylene group having from 1 to 10 carbon atoms; and n represents 0 or 1.
    Type: Application
    Filed: February 16, 2007
    Publication date: January 29, 2009
    Applicant: KURARAY CO., LTD.
    Inventors: Takashi Fukumoto, Ichihiro Aratani