Polycyclo Ring System Having One Of The Two Rings Which Form The Spiro As One Of The Cyclos Patents (Class 549/336)
  • Patent number: 10351501
    Abstract: The present invention relates to a compound having the formula (I), as well as a method for preparing such a compound, a cosmetic or pharmaceutic composition containing such a compound, and the use thereof as a depigmenting, lightening, bleaching or whitening agent and for treating pigmentation disorders, notably by topical application on the skin.
    Type: Grant
    Filed: March 4, 2016
    Date of Patent: July 16, 2019
    Assignee: TFCHEM
    Inventors: Géraldine Deliencourt-Godefroy, Lénaïg Lopes
  • Patent number: 9073897
    Abstract: Provided is a novel cyclic sulfonium salt compound which is useful for the prevention or treatment of diabetes and the like. The present invention relates to a novel cyclic sulfonium salt compound represented by general formula (I) or (II), an isomer or solvate of the compound, or a pharmaceutically acceptable salt of the compound or the isomer or solvate. The present invention also relates to an ?-glucosidase inhibitor, a pharmaceutical composition for preventing or treating diabetes, and an anti-diabetes food, each of which comprises the compound represented by general formula (I) or (II) and the like.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: July 7, 2015
    Assignees: KINKI UNIVERSITY, DIABETYM CO., LTD.
    Inventors: Osamu Muraoka, Genzoh Tanabe
  • Patent number: 8933251
    Abstract: A fluorinated monomer of cyclic acetal structure has formula (1) wherein R is a C1-C20 alkyl group which may be substituted with halogen or separated by oxygen or carbonyl, and Z is a divalent organic group which forms a ring with alkylenoxy and contains a polymerizable unsaturated group. A polymer derived from the fluorinated monomer may be endowed with appropriate water repellency, water sliding property, lipophilicity, acid lability and hydrolyzability and is useful in formulating a protective coating composition and a resist composition.
    Type: Grant
    Filed: March 20, 2013
    Date of Patent: January 13, 2015
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Satoshi Shinachi, Takeshi Kinsho, Koji Hasegawa, Yuji Harada, Jun Hatakeyama, Kazunori Maeda, Tomohiro Kobayashi
  • Publication number: 20140371445
    Abstract: The present invention relates to a quinic acid derivative, preparation process of the same and pharmaceutical uses thereof. The quinic acid derivative has a quinic acid-like structure which binds to CD28, blocks T-cell signal 2 pathway via CD28, and suppresses T-cell activation. The C-1 carboxyl group, the C-3 hydroxyl group and the C-4 hydroxyl group of quinic acid are modified to attenuate the cytotoxicity of the quinic acid derivative. The preparation process of the quinic acid derivative comprises 2 steps of: treating quinic acid with the first reagent in the presence of the acid catalyst to form an immediate; and treating the immediate with the second reagent to from the quinic acid derivative. With the ability to suppress T-cell activation, the quinic acid derivative is used to treats an autoimmune disease, an allergy, transplant rejection or other related immune disorder.
    Type: Application
    Filed: June 13, 2013
    Publication date: December 18, 2014
    Inventors: HUEIH-MIN CHEN, CHUNG-MING SUN, CHIH-YU HUANG
  • Patent number: 8901295
    Abstract: The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2; A is in particular CH or N; X is in particular CO, SO2, CS, and R1 is in particular H, R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group, R6 is in particular H or an alkyl group, and R7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: December 2, 2014
    Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite Montpellier 1, Universite Paris-EST Creteil val de Marne, Assistance Publique-Hopitaux de Paris, Centre National de la Recherche Scientifique
    Inventors: Jean-Francois Guichou, Lionel Colliandre, Hakim Ahmed-Belkacem, Jean-Michel Pawlotsky
  • Publication number: 20140054498
    Abstract: A liquid crystal composition comprising a chiral dopant compound represented by the following structure (Structure 1): wherein: R1 and R2 are independently hydrogen, —(C?O)R9, —(C?O)R10, alkyl, aryl, alkaryl, alkenyl, cycloalkyl, alkoxyaryl, or heterocyclic all either substituted or unsubstituted, or combine to form a carbocyclic or heterocyclic ring; and R3-R9 are as described in the disclosure. Also featured are liquid crystal compositions comprising a chiral dopant compound represented by any of Structure 2-4 as described in the disclosure.
    Type: Application
    Filed: August 24, 2012
    Publication date: February 27, 2014
    Applicants: Kent State University, Kent Displays Incorporated
    Inventors: Donald R. Diehl, Erica N. Montbach
  • Publication number: 20140051577
    Abstract: The invention relates to substituted 5-(bicyclo[4.1.0]hept-3-en-2-yl)penta-2,4-dienes and 5-(bicyclo[4.1.0]hept-3-en-2-yl)pent-2-ene-4-ines of the formula (I) and salts thereof, where the radicals R1, R2, R3, R4, R5, [X—Y] and Q are each as defined in the description, to processes for preparation thereof and to the use thereof for enhancing stress tolerance in plants with respect to abiotic stress, and/or for increasing plant yield.
    Type: Application
    Filed: March 28, 2012
    Publication date: February 20, 2014
    Inventors: Jens Frackenpohl, Thomas Müller, Ines Heinemann, Pascal Von Koskull-Döring, Christopher Hugh Rosinger, Isolde Häuser-Hahn, Martin Jeffrey Hills
  • Patent number: 8569518
    Abstract: The invention is directed to the use of compounds of formula (I), as fragrant agents. In this formula: —R3 and R4 are independently a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group, R5 is a C1-C6 alkyl group, a C2-C6 alkenyl group or a (CH2)0-2-aryl group, R6 is a C1-C6 alkyl group, a C2-C6 alkenyl group, a (CH2)0-2-aryl group or a C5-C6 cycloalkyl or cycloalkenyl group, and R7 is a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group; or R3, R4 and R5 are as above defined, and R6 and R7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl or cycloalkenyl group.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: October 29, 2013
    Assignee: V. Mane Fils
    Inventors: Jean-Jacques Chanot, Jean Mane, Caroline Plessis
  • Publication number: 20130203718
    Abstract: The present invention relates to a compound of formula (I): for its use as progesterone receptor antagonist, in particular for its use for the prevention and/or the treatment of cancer or uterine pathologies.
    Type: Application
    Filed: May 9, 2011
    Publication date: August 8, 2013
    Inventors: Marie-Edith Rafestin-Oblin, Mouad Alami, Hugues Loosfelt, Abdallah Hamze, Ali Junaid Khan, Abdellatif Tikad, Marc Lombes, Jean-Daniel Brion
  • Patent number: 8357358
    Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: January 22, 2013
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
  • Patent number: 8357810
    Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: January 22, 2013
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
  • Publication number: 20130017497
    Abstract: The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.
    Type: Application
    Filed: July 2, 2012
    Publication date: January 17, 2013
    Applicant: ACADEMIA SINICA
    Inventors: Tahsin J. CHOW, Chung-Chih WU, Ta-Hsien CHUANG, Hsing-Hung HSIEH, Hsin-Hui HUANG
  • Patent number: 8349890
    Abstract: The present invention refers to 5,7-dioxatetracyclo[9.2.1.01.9,04.8]tetradecane derivatives of formula I wherein R1-R3 have the same meaning as given in the description. The invention furthermore refers to their preparation and to perfume compositions and fragrance applications comprising them.
    Type: Grant
    Filed: June 29, 2009
    Date of Patent: January 8, 2013
    Assignee: Givaudan S.A.
    Inventors: Jerzy A. Bajgrowicz, Christopher Furniss
  • Publication number: 20120226031
    Abstract: Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer.
    Type: Application
    Filed: February 2, 2012
    Publication date: September 6, 2012
    Inventors: GARTH POWIS, PETER WIPF
  • Publication number: 20120165557
    Abstract: The invention is directed to the use of compounds of formula (I), as fragrant agents. In this formula: —R3 and R4 are independently a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group, R5 is a C1-C6 alkyl group, a C2-C6 alkenyl group or a (CH2)0-2-aryl group, R6 is a C1-C6 alkyl group, a C2-C6 alkenyl group, a (CH2)0-2-aryl group or a C5-C6 cycloalkyl or cycloalkenyl group, and R7 is a hydrogen atom, a C1-C6 alkyl group or a C2-C6 alkenyl group; or R3, R4 and R5 are as above defined, and R6 and R7 together with the carbon atom to which they are attached form a C5-C6 cycloalkyl or cycloalkenyl group.
    Type: Application
    Filed: July 28, 2010
    Publication date: June 28, 2012
    Inventors: Jean-Jacques Chanot, Caroline Plessis
  • Publication number: 20120129818
    Abstract: Ortho methoxy phenolic compounds are provided that include methylenedioxyphenyl ferulate and ferulylproline and derivatives thereof. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease, angina, stroke, and myocardial infarction, are further provided. The compounds are also useful in reducing low-density lipoprotein oxidation, improving or increasing vasodilation, and reducing plaque destabilization in a subject.
    Type: Application
    Filed: April 23, 2010
    Publication date: May 24, 2012
    Inventor: Desikan Rajagopal
  • Publication number: 20120101052
    Abstract: The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the invention include methyl-2,3,4-trihydroxy-1-O-(7,17-dioxoandrost-5-ene-3?-yl)-?-D-glucopyranosiduronate, 16?,3?-dihydroxy-5?-androstan-17-one or 3,7,16,17-tetrahydroxyandrost-5-ene, 3,7,16,17-tetrahydroxyandrost-4-ene, 3,7,16,17-tetrahydroxyandrost-1-ene or 3,7,16,17-tetrahydroxyandrostane that can be used in the treatment method.
    Type: Application
    Filed: May 13, 2011
    Publication date: April 26, 2012
    Inventor: James M. Frincke
  • Publication number: 20120087885
    Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 12, 2012
    Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
  • Publication number: 20120087880
    Abstract: The present invention pertains to a method of counteracting a malodor by introducing a malodor counteracting effective amount of a novel 3.2.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 12, 2012
    Inventors: Benjamin Amorelli, Johan Gerwin Lodewijk Pluyter, Adam P. Closson
  • Publication number: 20120088922
    Abstract: The present invention relates to novel compounds and their use in fragrance compositions. Novel 3.2.
    Type: Application
    Filed: October 8, 2010
    Publication date: April 12, 2012
    Inventors: Adam P. Closson, Benjamin Amorelli, Nicole O'Keefe
  • Patent number: 8067620
    Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: November 29, 2011
    Assignee: Medicines for Malaria Venture MMV
    Inventors: Jonathan L. Vennerstrom, Yuxiang Dong, Susan A. Charman, Sergio Wittlin, Jacques Chollet, Darren J. Creek, Xiaofang Wang, Kamaraj Spiraghavan, Lin Zhou, Hugues Matile, William N. Charman
  • Patent number: 8053576
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: November 8, 2011
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Publication number: 20110218162
    Abstract: The invention relates to the use of compounds to treat a number of conditions, such as thrombocytopenia, neutropenia or the delayed effects of radiation therapy. Compounds that can be used in the invention include methyl-2,3,4-trihydroxy-1-O-(7,17-dioxoandrost-5-ene-3?-yl)-?-D-glucopyranosiduronate, 16?,3?-dihydroxy-5?-androstan-17-one or 3,7,16,17-tetrahydroxyandrost-5-ene, 3,7,16,17-tetrahydroxyandrost-4-ene, 3,7,16,17-tetrahydroxyandrost-1-ene or 3,7,16,17-tetrahydroxyandrostane that can be used in the treatment method.
    Type: Application
    Filed: May 13, 2011
    Publication date: September 8, 2011
    Inventor: James M. Frincke
  • Patent number: 8013174
    Abstract: Specific photochromic spirodihydrophenanthropyrans and their use in synthetic resin materials of all kinds, particularly for ophthalmic purposes. The compounds of the invention are photochromic pyran compounds derived from 9,10-dihydrophenanthrene in which at least one of the two carbon atoms at positions 9 and 10 belongs to a further ring system and thus forms a spiro linkage point.
    Type: Grant
    Filed: May 9, 2008
    Date of Patent: September 6, 2011
    Assignee: Rodenstock GmbH
    Inventors: Udo Weigand, Manfred Melzig, Yven Rohlfing
  • Patent number: 7968601
    Abstract: the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n represents an integer being 1 or 2; R1 and R2 each independently represents hydrogen C1-4alkyl, NR9R10, C1-4alkyloxy; or R1 and R2 taken together with the carbon atom with which they are attached form a C3-6cycloalkyl; and where n is 2, either R1 or R2 may be absent to form an unsaturated bond; R3 represents a C6-12cycloalkyl, preferably selected from cylo-octanyl and cyclohexyl or R3 represents a monovalent radical having one of the following formulae ?wherein said C6-12cycloalkyl or monovalent radical may optionally be substituted with one, or where possible two, three or more substituents selected from the group consisting of C1-4alkyl, C1-4alkyloxy, halo or hydroxy; Q represents Het1 or Ar2 wherein said C3-8cycloalkyl, Het1 or Ar2 are optionally substituted with one or where possible two or more substituents selected from halo, C1-4alkyl, C1-4alkyloxy, hydroxy, nitro, NR5R
    Type: Grant
    Filed: December 18, 2007
    Date of Patent: June 28, 2011
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Joannes Theodorus Maria Linders, Gustaaf Henri Maria Willemsens, Ronaldus Arnodus Hendrika Joseph Gilissen, Christophe Francis Robert Nester Buyck, Greta Constantia Peter Vanhoof, Louis Jozef Elisabeth Van Der Veken, Libuse Jaroskova
  • Publication number: 20110124886
    Abstract: This invention relates to an improved process for the preparation of a compound of Formula (I), salts of the free base cis-adamantane-2-spiro-3?-8?-[[[(2?-amino-2?-methyl propyl)amino]carbonyl]methyl]-1?,2?,4?-trioxaspiro[4.5]decane wherein X can be an anion.
    Type: Application
    Filed: May 24, 2007
    Publication date: May 26, 2011
    Applicant: RANBAXY LABORATORIES LIMITED
    Inventors: Gyan Chand Yadav, Harish N. Dorwal, Srinivas Valavala, Vinod Kamar Sharma
  • Publication number: 20110104098
    Abstract: The present disclosure refers to 5,7-dioxatetracyclo[9.2.1.01.9,04.8]tetradecane derivatives of formula I wherein R1-R3 have the same meaning as given in the description. The disclosure furthermore refers to their preparation and to perfume compositions and fragrance applications including them.
    Type: Application
    Filed: June 29, 2009
    Publication date: May 5, 2011
    Applicant: GIVAUDAN SA
    Inventors: Jerzy A. Bajgrowicz, Christopher Furniss
  • Publication number: 20110065934
    Abstract: Production of a bicyclo[3.1.0]hexane derivative, useful as a metabotropic glutamate receptor modulator, becomes possible by a production method that includes converting a compound represented by Formula (II) into a compound represented by Formula (III) by reaction with an acyl group donor in the presence of a microorganism-derived enzyme, without using an expensive optically active trans hydroxy ester as a starting material and without employing a fluorination reaction requiring an ultralow temperature reaction. Furthermore, since asymmetric synthesis can be carried out in a stage closer to the final product, the production method is useful as a production method that can mass produce a bicyclo[3.1.0]hexane derivative.
    Type: Application
    Filed: November 19, 2010
    Publication date: March 17, 2011
    Applicant: TAISHO PHARMACEUTICAL CO., LTD.
    Inventors: Mitsuaki HIROTSUKA, Joji SASAKI, Hiroaki KAMIYAMA, Motoko OSHIDA, Takaaki ISHII
  • Publication number: 20110060140
    Abstract: An in vitro synthesis of (+) cortistatin A from readily available precursors is disclosed, as are the syntheses of related 17-aryl substituted compounds, the 17-aryl substituted compounds themselves and novel compounds useful in their preparation.
    Type: Application
    Filed: April 30, 2009
    Publication date: March 10, 2011
    Inventors: Ryan A. Shenvi, Carlos A. Guerrero, Jun Shi, Chuang-Chuang Li, Phil S. Baran
  • Publication number: 20110039701
    Abstract: The invention relates to novel compounds of the formula (I) in which X, Y, Z, A, B and G have the meanings given above, to a plurality of processes and intermediates for their preparation and to their use as pesticides and/or herbicides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, the phenyl-substituted bicyclooctane-1,3-dione derivates 33 and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to increasing the activity of crop protection compositions comprising in particular phenyl-substituted bicyclooctane-1,3-dione derivates by adding ammonium salts or phosphonium salts and, if appropriate, penetrants, to the corresponding compositions, to processes for their preparation and to their use in crop protection as insecticides and/or acaricides and/or for preventing unwanted plant growth.
    Type: Application
    Filed: March 30, 2010
    Publication date: February 17, 2011
    Applicant: Bayer CropScience AG
    Inventors: Alfred ANGERMANN, Guido Bojack, Reiner Fischer, Stefan Lehr, Jan Dittgen, Dieter Feucht, Isolde Häuser-Hahn, Christopher Hugh Rosinger, Arnd Voerste
  • Patent number: 7799931
    Abstract: Spirocyclic cyclohexane compounds corresponding to formula I a method for producing them, pharmaceutical compositions containing them, and methods of using them.
    Type: Grant
    Filed: February 17, 2009
    Date of Patent: September 21, 2010
    Assignee: Gruenenthal GmbH
    Inventors: Claudia Hinze, Otto Aulenbacher, Bernd Sundermann, Stefan Oberboersch, Elmar Friderichs, Werner Englberger, Babette-Yvonne Koegel, Klaus Linz, Hans Schick, Helmut Sonnenschein, Birgitta Henkel, Valerie Sarah Rose, Michael Jonathan Lipkin
  • Patent number: 7786314
    Abstract: Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: August 31, 2010
    Assignee: Taisho Pharmaceutical Co., Ltd
    Inventors: Frederick W. Hartner, Lushi Tan, Nobuyoshi Yasuda, Naoki Yoshikawa
  • Publication number: 20090187032
    Abstract: The present invention relates to a new industrial process for the synthesis of solvate-free 17?-acetoxy-11?-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB-2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process.
    Type: Application
    Filed: May 18, 2007
    Publication date: July 23, 2009
    Applicant: RICHTER GEDEON NYRT.
    Inventors: Lajosne Dancsi, Gyorgy Visky, Zoltan Tuba, Janos Csorgei, Csaba Molnar, Endrene Magyari
  • Patent number: 7557139
    Abstract: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: July 7, 2009
    Assignee: Emory University
    Inventors: Hariharan Venkatesan, James P. Snyder, Dennis C. Liotta, Susheng Wang
  • Patent number: 7417153
    Abstract: A method for the production of acetals and ketals of 3-amino-5-(hydroxymethyl) cyclopenlane-1,2-diols of formula (I): (and/or the enantiomer), where R1 is H, C1-6-alkyl, C3-8-cycloalkyl or benzyl and (i) R2 is methyl and R3 is ethyl, (ii) R2 is H and R3 is C1-6-alkyl or phenyl or (iii) R2 and R3 together form a group of formula —(CH2)n— with n=4 to 6, present as free amines or as salts of di- or tri-basic organic acids, starting from 2-acetyl-2-aza-bicyclo[2.2.1]hept-5-en-3-one of formula (II): (and/or the enantiomer). The method is equally useful, depending on the starting material, for the production of enantiomerically-pure compounds, or mixtures with arbitrary enantiomeric content.
    Type: Grant
    Filed: January 24, 2005
    Date of Patent: August 26, 2008
    Assignee: Lonza AG
    Inventors: Gareth-John Griffiths, Silvia Lange, Walter Brieden
  • Patent number: 7407984
    Abstract: The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not only to organic solvent including olive oil, but also to water, and therefore, being usable not only as oral drugs but also as injectable solutions. The antimalarial agent of the present invention contains a compound represented by the following general formula (I) [wherein Z represents an unsubstituted or optionally substituted alicyclic hydrocarbon group, R0 represents a water-soluble functional group, m represents any one of integers of from 0 to 6, n represents any one of integers of from 0 to 10.].
    Type: Grant
    Filed: March 11, 2003
    Date of Patent: August 5, 2008
    Assignee: Okayama University
    Inventors: Yusuke Wataya, Hye-Sook Kim, Masatomo Nojima
  • Publication number: 20080139826
    Abstract: Provided is a method for manufacturing fullerene 1,3-dioxolane conveniently at high yield. Fullerene 1,3-dioxolane is manufactured by reacting a fullerene oxide and a carbonyl compound in the presence of a catalyst.
    Type: Application
    Filed: May 26, 2005
    Publication date: June 12, 2008
    Applicant: RIKEN
    Inventors: Yasuo Shigemitsu, Yusuke Tajima
  • Patent number: 7385067
    Abstract: The invention relates to a process for the preparation of compounds containing at least one —CF2—O— bridge in the molecule, in which a) an acid is added onto at least one ketene dithioketal, b) the resultant bis(alkylthio)carbenium salt is reacted with at least one compound having at least one hydroxyl group in the presence of a base, c) and subsequently, preferably in situ, the resultant dithioorthoester is subjected to oxidative fluorodesulfurisation using a fluorinating agent and an oxidant to give the compound containing at least one —CF2—O— bridge in the molecule.
    Type: Grant
    Filed: June 2, 2006
    Date of Patent: June 10, 2008
    Assignee: Merck Patent GmbH
    Inventors: Peer Kirsch, Andreas Taugerbeck, Alexander Hahn
  • Patent number: 7371778
    Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: May 13, 2008
    Assignee: Medicines for Malaria Venture MMV
    Inventors: Jonathan L. Vennerstrom, Yuxiang Dong, Jacques Chollet, Hugues Matile, Xiaofang Wang, Kamaraj Spiraghavan, William N. Chapman
  • Patent number: 7365113
    Abstract: Flavan-based and spirodichroman compound-based phosphate esters prepared by reacting flavans and spirodichroman compounds with phosphorus oxychloride, monophenyl dichlorophosphate, or diphenyl chlorophosphate compounds are described. The flavans and spirodichroman compounds can be synthesized by the reaction of resorcinol with aliphatic acetone. Such phosphate esters can be used as flame retardants.
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: April 29, 2008
    Inventors: Raj B. Durairaj, Gary A. Jesionowski
  • Patent number: 7319155
    Abstract: Novel 7,7-disubstituted (5H,9H)-6,8-dioxabenzocycloheptene compounds having the structural formula (I): are useful intermediates in the synthesis of non-steroidal derivatives of vitamin D.
    Type: Grant
    Filed: November 14, 2006
    Date of Patent: January 15, 2008
    Assignee: Galderma Research & Development
    Inventors: Eric Terranova, Jean-Claude Pascal
  • Patent number: 7169941
    Abstract: A photochromic composition and a coating composition comprising a molecular compound of a chromene compound and an aromatic compound. The photochromic composition provides a photochromic optical material as a cured product and the coating composition is applied to a lens substrate and cured to provide a photochromic optical material. The above molecular compound is also provided.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: January 30, 2007
    Assignee: Tokuyama Corporation
    Inventors: Hironobu Nagoh, Junji Momoda
  • Patent number: 7157589
    Abstract: The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R4, R5 and R6 are as described in the specification.
    Type: Grant
    Filed: March 1, 2004
    Date of Patent: January 2, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Joachim Ernst Berkner, Scott Duncan, John Mills
  • Patent number: 7034166
    Abstract: A novel process for efficiently and easily producing a compound represented by the formula: wherein ring A is a benzene ring that may be optionally further substituted in addition to the group represented by W, or a salt thereof; which comprises reacting a compound represented by the formula: wherein R1 and R2 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, Y is a halogen atom, ring A is a benzene ring that may be optionally further substituted in addition to the group represented by Y and ring B is an optionally substituted benzene ring, or a salt thereof, with a compound represented by the formula: WH wherein W is wherein ring C is an optionally substituted benzene ring, ring D is an optionally substituted 5- to 7-membered nitrogen-containing heterocyclic ring, R3 is a hydrogen atom, an aliphatic hydrocarbon group containing an aromatic group or an acyl group, and R4 is a hydrogen atom, an optio
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: April 25, 2006
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Hiroyuki Tawada, Makoto Yamashita, Yujiro Ono
  • Patent number: 6908918
    Abstract: The present invention provides compounds of general formula I or II: wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I or II, intermediates and processes useful for preparing compounds of formula I or II, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I or II.
    Type: Grant
    Filed: April 14, 2003
    Date of Patent: June 21, 2005
    Assignee: Regents of the University of California
    Inventors: Trevor C. McMorris, Michael J. Kelner
  • Patent number: 6906098
    Abstract: Disclosed herein are mixed steroidal tetraoxanes having the following structural formula 1 wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or isopropyl; R2 is H, methyl, or ethyl; R3 is H, methyl, or ethyl; R4 is H, methyl, ethyl, tert-butyl, phenyl, p-hydroxyphenyl, p-methoxyphenyl, or p-nitrophenyl, or wherein Y is a C1-C4 straight or branched-chain alkoxy, or wherein W is N, R5 is hydrogen, methyl, ethyl, n-propyl, isopropyl, or methyl ethanoate 2-yl, and R6 is hydrogen, methyl, ethyl, or n-propyl, or R5 and R6 are part of a pyrrolidine or piperidine ring; X is a C1-C4 straight or branched-chain alkoxy, a primary amino, a N-alkylamino wherein the alkyl is a straight-chain alkyl groups containing from 1 to 4 carbon atoms, methyl ethanoate-2-yl, N-phenylamino, p-nitrophenyl, N,N-dimethylamino, N,N-diethylamino, N,N-di(n-propyl)amino, N-pyrrolidino, or N-piperidino as single compounds, and any mixture of all possible stereoisomers at C(4?).
    Type: Grant
    Filed: February 7, 2003
    Date of Patent: June 14, 2005
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Bogdan Solaja, Dejan M. Opsenica, Gabriella Pocsfalvi, Wilbur K. Milhous, Dennis E. Kyle
  • Publication number: 20040173782
    Abstract: A photochromic composition and a coating composition comprising a molecular compound of a chromene compound and an aromatic compound. The photochromic composition provides a photochromic optical material as a cured product and the coating composition is applied to a lens substrate and cured to provide a photochromic optical material. The above molecular compound is also provided.
    Type: Application
    Filed: January 21, 2004
    Publication date: September 9, 2004
    Inventors: Hironobu Nagoh, Junji Momoda
  • Patent number: 6777441
    Abstract: The present invention provides synthetic methods and compositions for treatment of autoimmune and anti-inflammatory disorders comprising administering an effective amount of a derivative of triptolide alone or in combination or alternation with other anti-autoimmune or anti-inflammatory compounds.
    Type: Grant
    Filed: October 2, 2001
    Date of Patent: August 17, 2004
    Assignee: Emory University
    Inventors: Susheng Wang, Dennis C. Liotta, James P. Snyder, Hariharan Venkatesan
  • Patent number: 6737438
    Abstract: In the present invention relates to a novel series of antimalarial 1,2,4-trioxanes analogues of general formula 7, wherein R represents cycloalkyl groups selected from the groups consisting of cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl or aryl groups selected from phenyl, 4-bromophenyl and 4-chlorophenyl, R1 and R2 represent hydrogen, alkyl group selected from methyl, ethyl, propyl and decyl, aryl selected from phenyl or parts of a cyclic systems such as cyclopentane, cyclohexane, substituted cyclohexane, cycloheptane bicyclo(2.2.1)heptane, adamantane and its preparation thereof; several of these novel compounds show promising antimalarial activity against multidrug resistant malaria in mice.
    Type: Grant
    Filed: March 28, 2002
    Date of Patent: May 18, 2004
    Assignee: Council of Scientific and Industrial Research
    Inventors: Chandan Singh, Pallvi Tiwari, Sunil Kumar Puri
  • Patent number: 6716832
    Abstract: The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I): in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenalkyl, halogeno-alkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenyl-alkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups: in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.
    Type: Grant
    Filed: May 2, 2002
    Date of Patent: April 6, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Folker Lieb, Reiner Fischer, Alan Graff, Udo Schneider, Thomas Bretschneider, Christoph Erdelen, Wolfram Andersch, Mark-Wilhelm Drewes, Markus Dollinger, Ingo Wetcholowsky, Randy Allen Myers