Chalcogen Bonded Directly To The Hetero Ring Patents (Class 549/416)
  • Patent number: 4364956
    Abstract: Compounds are described of the formula ##STR1## in which R.sup.1 is COOR.sup.5, CONHR.sup.5, cyano, 5-tetrazolyl or 5-tetrazolylaminocarbonyl, where R.sup.5 is hydrogen or C.sub.1-6 alkyl; R.sup.2 is hydrogen or C.sub.1-6 alkyl; R.sup.3 is a group of the formulaR.sup.6 --(Z).sub.m --where m is O or 1, Z is O, S, SO, SO.sub.2 or CO, and R.sup.6 phenyl optionally substituted by one or more group selected from halogen, C.sub.1-4 alkyl, C.sub.3-6 cycloalkyl, C.sub.1-4 alkoxy, benzyloxy, hydroxy, nitro, C.sub.1-4 alkylthio, C.sub.1-4 alkylsulphinyl, C.sub.1-4 alkylsulphonyl, amino and NHR.sup.7 where R.sup.7 is C.sub.2-6 acyl; and R.sup.4 is hydrogen, C.sub.1-6 alkyl or halogen; and salts thereof. These compounds have pharmaceutical properties and in particular are useful in the treatment of immediate hypersensitivity conditions such as asthma.
    Type: Grant
    Filed: September 17, 1981
    Date of Patent: December 21, 1982
    Assignee: Lilly Industries Limited
    Inventors: Barry P. Clark, William J. Ross, Alec Todd
  • Patent number: 4359467
    Abstract: Prostanoic acid derivatives of the formula ##STR1## wherein R.sub.1 is an acid, ester, amide or hydroxyalkylene group; R.sub.2 and R.sub.3 are H or alkyl; R.sub.4 and R.sub.5 are both CH.sub.3 or one is Cl and the other is CH.sub.3 ; A is CH.sub.2 CH.sub.2 or --CH.dbd.CH; B is CH.sub.2 CH.sub.2, trans- ##STR2## W is free or functionally modified hydroxyalkylene or carbonyl; Z is free or functionally modified hydroxymethylene or carbonyl; X Y is either ##STR3## or, when Z is free or functionally modified hydroxymethylene, ##STR4## or, when Z is free or functionally modified carbonyl, --CH.dbd.CH--, R.sub.12 being H, CH.sub.3, CN or free or functionally modified hydroxy; and physiologically acceptable salts thereof when R.sub.1 is an acid group, possess pharmacological activity, including abortion triggering activity.
    Type: Grant
    Filed: April 22, 1981
    Date of Patent: November 16, 1982
    Assignee: Schering Aktiengesellschaft
    Inventors: Helmut Vorbruggen, Norbert Schwarz, Olaf Loge, Walter Elger
  • Patent number: 4359424
    Abstract: The compound, cyclopropylmethyl 4-(2-cyclopropylcarbonyloxyethoxy)benzoate, novel intermediates therefor, synthesis thereof, and the use of said compound for the control of pests.
    Type: Grant
    Filed: July 9, 1981
    Date of Patent: November 16, 1982
    Assignee: Zoecon Corporation
    Inventors: Clive A. Henrick, Gerardus B. Staal
  • Patent number: 4355170
    Abstract: The imidazole derivatives of the general formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.2 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms, R.sup.3 represents a straight- or branched-chain alkyl group containing from 1 to 10 carbon atoms, and m and n, which may be the same or different, each represent zero, or an integer of 1 to 10, and non-toxic acid addition salts thereof, and, when R.sup.1 represents a hydrogen atom, non-toxic salts thereof, are new compounds. These compounds have a strong inhibitory effect on thromboxane synthetase from rabbit platelet microsomes, and are useful as therapeutically active agents for inflammation, hypertension, thrombus, cerebral apoplexy and asthma.
    Type: Grant
    Filed: May 2, 1979
    Date of Patent: October 19, 1982
    Assignees: Ono Pharmaceutical Co., Ltd., Kissei Pharmaceutical Co., Ltd.
    Inventors: Masaki Hayashi, Tadao Tanouchi, Masanori Kawamura, Yoichi Iguchi
  • Patent number: 4343948
    Abstract: 2,6-Di-tert-butyl-4-methyl thiopyrylium salt of the formula (I): ##STR1## wherein Z.sup..crclbar. is an anionic function and certain intermediates encountered in its synthesis.
    Type: Grant
    Filed: March 28, 1980
    Date of Patent: August 10, 1982
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Kouichi Kawamura, Harumi Katsuyama, Hideo Sato
  • Patent number: 4343796
    Abstract: The invention relates to compounds of the formula: ##STR1## in which R.sub.1 and R.sub.2 are the same or different groups selected from hydrogen or acyl orR.sub.1 and R.sub.2 together may represent an acetal group, andX and Y are the same or different groups selected from hydroxy, an etherified hydroxy and an esterified hydroxy group,having valuable lipid lowering, anti-inflammatory and immuno-modulating properties.
    Type: Grant
    Filed: June 11, 1981
    Date of Patent: August 10, 1982
    Assignee: AKZO NV
    Inventor: Marinus B. Groen
  • Patent number: 4336196
    Abstract: Sodium salts of phenylmalonic acid mono-esters are produced by reacting a phenylacetic acid ester with carbon dioxide in the presence of a sodium substituted compound, which is prepared by substituting a sodium atom for a hydrogen atom of an organic compound selected from a group consisting of acetylene, cumene, triphenylmethane, methyl-methylthiomethyl-sulfoxide and dimethyl-sulfoxide, at a temperature in a range of -20.degree. C. to -40.degree. C.
    Type: Grant
    Filed: July 21, 1980
    Date of Patent: June 22, 1982
    Assignees: Nippon Soda Company Limited, Shionogi Company Limited
    Inventors: Shigeo Kitamura, Kazuo Yoshioka, Yoshiharu Seriyama, Hiroshi Misuta