Polycyclo Ring System Having The Hetero Ring As One Of The Cyclos Patents (Class 549/432)
  • Patent number: 10899773
    Abstract: In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 26, 2021
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C Nicolaou, Quan Cai
  • Publication number: 20150080578
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: July 8, 2014
    Publication date: March 19, 2015
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Patent number: 8859614
    Abstract: Analogs of (?)-Picropodophyllin, synthesis thereof, and uses in pharmaceuticals as inhibitors of IGF1RK.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: October 14, 2014
    Assignee: University of Nebraska—Lincoln
    Inventors: David B. Berkowitz, Sylvain Broussy
  • Publication number: 20140163242
    Abstract: Intermediates and methods of their use in the synthesis of analogs of halichondrin B are provided.
    Type: Application
    Filed: December 4, 2013
    Publication date: June 12, 2014
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Charles E. Chase, Francis G. Fang
  • Patent number: 8729118
    Abstract: The present invention relates to the use of new and known dithiine derivatives for controlling unwanted microorganisms, more particularly phytopathogenic fungi, in crop protection, in the household and hygiene sector and in the protection of materials, and also to new dithiine derivatives, to processes for preparing them, to their use, and to crop protection compositions comprising these new dithiine derivatives.
    Type: Grant
    Filed: April 14, 2011
    Date of Patent: May 20, 2014
    Assignee: Bayer CropScience AG
    Inventors: Thomas Seitz, Jürgen Benting, Ulrike Wachendorff-Neumann
  • Publication number: 20140128459
    Abstract: The present invention relates to solid forms of 13-(N-Boc-?-isobutylserinyl)-14-?hydroxybaccatin III 1, 14-carbonate (Ortataxel). Amorphous Form A, crystalline Form B, mixtures thereof and processes for preparing them are disclosed. Amorphous Form A is prepared by fast precipitation of Ortataxel from a mixture of acetone and water. Form A transforms in Form B when suspended and stirred in a mixture of ethanol and water for 4-8 hours. If the suspension is stirred for less than 4 hours, mixtures of Form B and Form A are obtained. Form B or mixtures of Forms A and B can also be obtained dissolving Ortataxel in a protic organic solvent, followed by addition of water.
    Type: Application
    Filed: December 10, 2013
    Publication date: May 8, 2014
    Applicant: Indena S.p.A.
    Inventors: Daniele Ciceri, Nicola Sardone, Bruno Gabetta, Maurizio Ricotti
  • Patent number: 8697892
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: April 15, 2014
    Assignee: GFV, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Patent number: 8362283
    Abstract: The present invention relates to methods for the synthesis of galanthamine, morphine, intermediates, salts and derivatives thereof. In preferred embodiments, the invention relates to methods for improving the efficiency and overall yield of said morphine, morphine related derivatives and intermediates thereof. In further embodiments, the invention relates to methods for improving the efficiency and overall yield of galanthamine and intermediates thereof.
    Type: Grant
    Filed: May 12, 2010
    Date of Patent: January 29, 2013
    Assignee: Board of Regents, The University of Texas System
    Inventors: Philip D. Magnus, Benjamin P. Fauber, Neeraj Sane
  • Patent number: 8362170
    Abstract: Provided is a polymerizable compound represented by the following general formula (ca-1) or (cb-1): wherein the variables in the formulae are defined in the specification.
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: January 29, 2013
    Assignee: FUJIFILM Corporation
    Inventors: Shuji Hirano, Kaoru Iwato, Hiroshi Saegusa, Yusuke Iizuka
  • Patent number: 8252877
    Abstract: Provided is a polymerizable compound represented by the following general formula (ca-1) or (cb-1): wherein the variables in the formulae are defined in the specification.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: August 28, 2012
    Assignee: FUJIFILM Corporation
    Inventors: Shuji Hirano, Kaoru Iwato, Hiroshi Saegusa, Yusuke Iizuka
  • Patent number: 8193379
    Abstract: The invention relates to a method for synthesizing 4?-amino-4?-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4?-halogenoacetamido-4?-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4?-amino-4?-demethyl-4-desoxypodophyllotoxin.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: June 5, 2012
    Inventors: Yves Guminski, Martial Grousseaud, Thierry Imbert
  • Publication number: 20120077722
    Abstract: The present invention relates primarily to the novel compound of the formula (II) and certain mixtures comprising the compound of the formula (II) and use thereof as perfume. In addition the invention relates to perfume mixtures and perfumed products comprising a (preferably sensorially effective) amount of the compound of the formula (II) or a mixture according to the invention.
    Type: Application
    Filed: September 28, 2011
    Publication date: March 29, 2012
    Applicant: SYMRISE AG
    Inventors: Erich Dilk, Marcus Eh, Horst Surburg
  • Publication number: 20120004429
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 5, 2012
    Applicant: Genta Incorporated
    Inventors: John K. Thottathil, Raymond P. Warrell, JR.
  • Publication number: 20110269722
    Abstract: The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of formula I or intermediates thereof and one more of pharmaceutically acceptable carriers, vehicles or diluents. The invention further provides methods of preparation and methods of use of prodrugs including NO-releasing prodrugs, double prodrugs and mutual prodrugs comprising the compounds of formula I.
    Type: Application
    Filed: December 23, 2010
    Publication date: November 3, 2011
    Inventor: Apparao Satyam
  • Publication number: 20110213026
    Abstract: The invention relates to the use, or methods (especially with regard to animals, especially human, that are in need of such treatment) comprising the use, of an extract and/or one or more natural compounds from plants or parts of plants, respectively, from a genus selected from the group consisting of Schisandra, Illicium, Kadsura, Steganotaenia and Magnolia, alone or as supplement, as active ingredient in the regulation of body weight and/or fat loss and/or for the management of obesity, either in humans or in animals, to the use of said extract and/or natural compound(s) or mixtures in the manufacture of a pharmaceutical or nutraceutical formulation for the regulation of body weight and/or fat loss and/or for the management of obesity either in humans or in animals. The above extract and/or compound(s) can further be used to reduce one or more adverse metabolic parameters in a subject.
    Type: Application
    Filed: July 29, 2008
    Publication date: September 1, 2011
    Applicant: INTERMED DISCOVERY GMBH
    Inventors: Torsten Grothe, Ernst Roemer, Thomas Henkel
  • Publication number: 20110178050
    Abstract: There is disclosed use of certain picro derivatives of cyclolignans for prophylaxis or treatment of diseases or conditions characterised by a hyperactive immune system. Examples of cyclolignans according to the invention include picropodophyllin, deoxypicropodophyllin, anhydropicropodophyllol or deoxyanhydropicropodophyllol.
    Type: Application
    Filed: June 18, 2009
    Publication date: July 21, 2011
    Applicant: Axelar AB
    Inventors: Magnus Axelson, Olle Larsson
  • Patent number: 7932406
    Abstract: The invention relates to a method for synthesizing 4.beta.-amino-4?-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4.beta.-halogenoacetamido-4?-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4.beta.-amino-4?-demethyl-4-desoxypodophyllotoxin.
    Type: Grant
    Filed: July 19, 2006
    Date of Patent: April 26, 2011
    Assignee: Pierre Fabre Medicament
    Inventors: Yves Guminski, Martial Grousseaud, Thierry Imbert
  • Publication number: 20110053967
    Abstract: The present invention relates to novel podophyllotoxin derivatives substituted in the 4-position by a substituted (poly)aminoalkylaminoacetamide chain, to their process of preparation and to their use as medicament as anticancer agents.
    Type: Application
    Filed: November 10, 2010
    Publication date: March 3, 2011
    Inventors: Thierry IMBERT, Yves GUMINSKI, Jean-Marc BARRET, Anna KRUCZYNSKI
  • Patent number: 7863321
    Abstract: The present invention relates to synergistic combinations of the compound 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from anthracyclines and topisomerase II inhibitors, which have anti-tumor activity. Preferably, the present invention relates to synergistic combinations of the compound 5,6-dimethylxanthenone-4-acetic acid (DMXAA) and a compound selected from etoposide, and doxorubicin. More particularly, the invention is concerned with the use of such combinations in the treatment of cancer and pharmaceutical compositions containing such combinations. The invention further provides for methods of preparing the combinations of the invention.
    Type: Grant
    Filed: July 30, 2007
    Date of Patent: January 4, 2011
    Assignee: Cancer Research Technology Limited
    Inventors: William R. Wilson, Bronwyn G. Siim
  • Publication number: 20100234454
    Abstract: The present invention relates to the use of vanilloid receptor (VR) antagonists, and more particularly vanilloid receptor 1 (VR1) antagonist, as analgesics in the treatment and/or prohylaxis of cnidaria envenomations.
    Type: Application
    Filed: June 11, 2007
    Publication date: September 16, 2010
    Applicants: Katholieke Universiteit Leuven K.U. Leuven R&D, University of Hawaii
    Inventors: Eva Cuypers, Evert Karlsson, Jan Tytgat, Angel Yanagihara
  • Publication number: 20100197646
    Abstract: A sterile composition of a pharmaceutical compound is prepared by combining solvent with a non-sterile pharmaceutical compound to form a solution and filtering to yield a sterile pharmaceutical compound, optionally removing all or part of the solvent, and under sterile conditions combining the compound with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 13, 2010
    Publication date: August 5, 2010
    Applicant: RESOLUTION CHEMICALS LIMITED
    Inventors: Parveen Bhatarah, Alan Kenneth Greenwood
  • Publication number: 20100168420
    Abstract: Taxol derivatives or their salts having the formula as following: Wherein, R1, R2, Z1, Z2, Z3 and Z4 are defined as the description. Their preparation methods and their use as antitumor agent are also disclosed.
    Type: Application
    Filed: January 5, 2007
    Publication date: July 1, 2010
    Inventor: Piaoyang Sun
  • Patent number: 7728020
    Abstract: The present invention relates to new amino acid derivatives, process for the production, their use, in particular in transplantation, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: March 8, 2005
    Date of Patent: June 1, 2010
    Assignee: Novartis AG
    Inventors: Klaus Hinterding, Klemens Högenauer
  • Patent number: 7709526
    Abstract: Compounds which inhibit the insulin-like growth factor-1 receptor (IGF-1 R) and methods for using them for treating IGF-1 R dependent diseases, such as cancer.
    Type: Grant
    Filed: February 3, 2006
    Date of Patent: May 4, 2010
    Assignee: Biovitrum AB
    Inventors: Olle Larsson, Magnus Axelson
  • Patent number: 7671219
    Abstract: Provided is a method for manufacturing fullerene 1,3-dioxolane conveniently at high yield. Fullerene 1,3-dioxolane is manufactured by reacting a fullerene oxide and a carbonyl compound in the presence of a catalyst.
    Type: Grant
    Filed: May 26, 2005
    Date of Patent: March 2, 2010
    Assignee: Institute of Medicinal Molecular Design, Inc.
    Inventors: Yasuo Shigemitsu, Yusuke Tajima
  • Publication number: 20100048923
    Abstract: The present invention is to provide ATR inhibitor containing tricyclic compound including Schizandrins and Gomisins as an active constituent, useful for an inhibitor of ATR protein kinase.
    Type: Application
    Filed: October 18, 2006
    Publication date: February 25, 2010
    Inventors: Hiroshi Nishida, Yasuo Hamamori, Tetsuya Konishi
  • Patent number: 7652065
    Abstract: Novel tellurium-containing compounds and uses thereof as immunomodulators are disclosed.
    Type: Grant
    Filed: September 15, 2005
    Date of Patent: January 26, 2010
    Assignee: BioMAS Ltd.
    Inventors: Michael Albeck, Benjamin Sredni
  • Publication number: 20090271879
    Abstract: Compounds, compositions, methods of making, and methods of using analogues of (?)-picropodophyllin, as well as a transgenic animal model and its use for identifying anticancer agents.
    Type: Application
    Filed: February 9, 2009
    Publication date: October 29, 2009
    Inventors: David B. Berkowitz, Sylvain Broussy, Argiris Efstratiadis, Apostolos Klinakis, Matthias Szabolcs
  • Patent number: 7601682
    Abstract: Mixtures are described which comprise or consist of 3-(4-methylcyclohex-3-enyl)butyraldehyde (limonenal) and (4aR,5R,7aS,9R)-octahydro-2,2,5,8,8,9a-hexamethyl-4H-4a,9-methanoazuleno(5,6-d)-1,3-dioxole (Ambrocenide®), the weight ratio of limonenal to Ambrocenide® being in the range from 150:1 to 2500:1.
    Type: Grant
    Filed: December 31, 2007
    Date of Patent: October 13, 2009
    Assignee: SYMRISE GmbH & Co. KG
    Inventors: Fred Naraschkewitz, Marcus Eh
  • Publication number: 20090202662
    Abstract: A process for the production of a substance or composition for the therapeutic or prophylactic treatment of erectile dysfunction or the enhancement of libido in a male human or animal subject comprises the step of formulating the substance or composition from at least one of plant material and an extract of plant material of at least one plant species of the family Geraniaceae.
    Type: Application
    Filed: May 23, 2007
    Publication date: August 13, 2009
    Applicant: CSIR
    Inventors: Gerda Fouche, Eric Khorombi, Vinesh Jaichand Maharaj
  • Publication number: 20090137826
    Abstract: The invention relates to a method for synthesizing 4?-amino-4?-demethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4?-halogenoacetamido-4?-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4?-amino-4?-demethyl-4-desoxypodophyllotoxin.
    Type: Application
    Filed: July 19, 2006
    Publication date: May 28, 2009
    Inventors: Yves Guminski, Martial Grousseaud, Thierry Imbert
  • Patent number: 7468236
    Abstract: Chemically amplified resist compositions comprising amine compounds having a fluorinated alkyl group offer an excellent resolution and a precise pattern profile and are useful in microfabrication by KrF, ArF, F2, EUV, EB or X-ray lithography. They are also effective in the immersion lithography.
    Type: Grant
    Filed: October 6, 2006
    Date of Patent: December 23, 2008
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Jun Hatakeyama
  • Publication number: 20080300254
    Abstract: Compounds of Formula I are described: preferably subject to the proviso that either (a) R2 and R3 together form —O—CH(R10)—O—, or (b) R5 and R6 together form —O—CH(R10)—O—, wherein R10 is H, halo, or loweralkyl. Pharmaceutical salts, formulations, and methods of using the same in the treatment of cancer are also described.
    Type: Application
    Filed: December 20, 2006
    Publication date: December 4, 2008
    Inventors: Kuo-Hsiung Lee, Linyi Wei, Kenneth F. Bastow, Arnold Brossi, Tian-Shung Wu
  • Publication number: 20080194678
    Abstract: A process to obtain synthetic and semi-synthetic derivatives of lignans, especially dibenzylbutyrolactonic, tetrahydrofuranic, aryltetralynic, furofuranic and dibenzocyclooctanic lignans obtained by means of partial synthesis and/or full synthesis or also by isolation from plant extracts. It refers to a process to obtain synthetic and semi-synthetic derivatives of (?)-cubebin, such as: (?)-O-acetylcubebin; (?)-O-methylcubebin; (?)-O—N,N-(dimethylamino-ethyl)-cubebin; (?)-hinokinin; (?)-6,6?-dinitroinokinine; (?)-O-benzylcubebin; (?)-6,6?-diaminoinokinin, (?)-6,6?-dinitroinokinin, as well as to obtain dibenzocyclooctanic lignans from dibenzylbutyrolactoinic lignans by means of structural modifications in the positions 7, 7?, 8, 8?, 9? and in the aromatic rings (introduction and/or substitution of functional groups such as: —OH, —CO2H, —CO2CH3, —NO2, —NH2, —OCH3, —OAc, —SO2CH3, —SO2NH2, prenyl and halogens) is provided. A therapeutic method using the derivatives is also provided.
    Type: Application
    Filed: July 14, 2006
    Publication date: August 14, 2008
    Applicant: Fundacao de Amparo a Pesquissa do Estado de Aao Pa
    Inventors: Marcio Luis Andrade e Silva, Rosangela da Silva, Vanderlei Rodrigues, Olavo dos Santos Pereira, Ademar Alves da Silva Filho, Paulo Marcos Donate, Sergio Albuquerque, Jairo Kenupp Bastos
  • Publication number: 20080139519
    Abstract: The present invention provides a method for the sterilization of a labile glucocorticosteroid, which method comprises heat-treating by moist heat the labile glucocorticosteroid in the form of a suspension for a sterilizing-effective time. The methods and compositions according to the invention are useful as therapeutic tools to prevent, reverse, and/or reduce the symptoms of allergic and/or inflammatory conditions in a mammalian patient. The invention also provides methods and compositions, which may be manipulated and fine-tuned to fit the condition(s) to be treated while producing fewer side effects.
    Type: Application
    Filed: May 17, 2005
    Publication date: June 12, 2008
    Inventors: Adrian Ashley, Paul Lamb, Donald MacDonald, John Miller, Martin J. Oliver, Mathew Pollard
  • Publication number: 20080139826
    Abstract: Provided is a method for manufacturing fullerene 1,3-dioxolane conveniently at high yield. Fullerene 1,3-dioxolane is manufactured by reacting a fullerene oxide and a carbonyl compound in the presence of a catalyst.
    Type: Application
    Filed: May 26, 2005
    Publication date: June 12, 2008
    Applicant: RIKEN
    Inventors: Yasuo Shigemitsu, Yusuke Tajima
  • Patent number: 7261995
    Abstract: Chemically amplified resist compositions comprising nitrogen-containing organic compounds having a 7-oxanorbornane-2-carboxylic ester structure have resolution and provide a precise pattern profile and are useful in microfabrication using electron beams or deep-UV light.
    Type: Grant
    Filed: April 21, 2005
    Date of Patent: August 28, 2007
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Takeru Watanabe, Koji Hasegawa, Katsuya Takemura, Kazumi Noda
  • Patent number: 6906101
    Abstract: A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-?-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: June 14, 2005
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta, Alessandro Pontiroli
  • Patent number: 6903086
    Abstract: This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein G1 is selected from the group consisting of a, b1 and b2, and A and G2 are as defined in the specification; or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: June 7, 2005
    Assignee: SYNTEX (U.S.A.) LLC
    Inventors: Francisco Javier Lopez-Tapia, Dov Nitzan, Counde O'Yang
  • Patent number: 6881850
    Abstract: The present invention relates to specific photochromic heterocyclically annellated indenochromene derivatives and the use thereof in plastics of all types, particularly for ophthalmic applications.
    Type: Grant
    Filed: November 25, 2003
    Date of Patent: April 19, 2005
    Assignee: Rodenstock GmbH
    Inventors: Claudia Mann, Manfred Melzig, Udo Weigand
  • Patent number: 6872841
    Abstract: Etoposide analogs such as 4?-O-demethyl-4?-[4?-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy-podophyllotoxin (12) and 4?-O-demethyl-4?-[4?-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-desoxypodophyllotoxin (13) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: March 29, 2005
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Zhiyan Xiao, Kenneth F. Bastow
  • Patent number: 6861537
    Abstract: The synthesis of taxol and other tricyclic and tetracyclic taxanes.
    Type: Grant
    Filed: July 12, 2002
    Date of Patent: March 1, 2005
    Assignee: Florida State University
    Inventors: Robert A. Holton, Carmen Somoza, Hyeong Baik Kim, Mitsuru Shindo, Ronald J. Biediger, P. Douglas Boatman, Chase Smith, Feng Liang, Krishna Murthi
  • Patent number: 6686386
    Abstract: The present invention relates to pharmaceutical and cosmetic compositions comprising at least one agonist ligand, which is specific for receptors of the RAR-&ggr; type, which are characterized as inducers of apoptosis in at least one cell population in which apoptosis can be induced by activating receptors of the RAR-&ggr; type. In one aspect of the present invention, there is provided a method of combating photoinduced or chronological ageing of skin, said method comprising administering an effective amount of at least one agonist ligand which is specific for receptors of the RAR-&ggr; type to combat photoinduced or chronological aging of skin, wherein the agonist ligand has a ratio R which is equal to or greater than 10.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: February 3, 2004
    Assignee: Galderma Research & Development S.N.C.
    Inventors: Laszlo Fesus, Zsuzsa Szondy, Uwe Reichert
  • Publication number: 20040006126
    Abstract: Etoposide analogs such as 4′-O-demethyl-4&bgr;-[4″-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy-podophyllotoxin (12) and 4′-O-demethyl-4&bgr;-[4″-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-desoxypodophyllotoxin (13) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.
    Type: Application
    Filed: January 22, 2003
    Publication date: January 8, 2004
    Inventors: Kuo-Hsiung Lee, Zhiyan Xiao, Kenneth F. Bastow
  • Patent number: 6660727
    Abstract: The present invention relates to specific photochromic heterocyclically annellated indenochromene derivatives and the use thereof in plastics of all types, particularly for ophthalmic applications.
    Type: Grant
    Filed: July 10, 2001
    Date of Patent: December 9, 2003
    Assignee: Rodenstock GmbH
    Inventors: Claudia Mann, Manfred Melzig, Udo Weigand
  • Patent number: 6653344
    Abstract: The present invention relates to the use of a dibenzocyclooctane lignan derivative of the following general formula (I) for treatment of neurodegenerative disorders: wherein R1 is H or C1-4 lower alkyl; R2, R3, R4 and R5 are respectively H, OH, C1-4 lower alkyl, C1-4 lower alkoxy, or R2 and R3 or R4 and R5 are respectively combined to form the group of —OCH2O—. Pharmaceutical preparations containing the dibenzocyclooctane lignan derivative as the active ingredient also are disclosed.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: November 25, 2003
    Assignee: Elcom Bio Technology Co., Ltd.
    Inventors: Young-Joong Kim, Sang-Hyun Sung, Mi-Gyeong Lee, So-Ra Kim, Gyeong-A Gu, Won-Ju Jeong
  • Patent number: 6566393
    Abstract: Etoposide analogs such as 4′-O-demethyl-4&bgr;-[4″-(methyl-L-tyrosine-N-carbonyl)-anilino]-4-desoxy-podophyllotoxin (12) and 4′-O-demethyl-4&bgr;-[4″-(methyl-L-tryptophan-N-carbonyl)-anilino]-4-desoxypodophyllotoxin (13) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: May 20, 2003
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Zhiyan Xiao, Kenneth F. Bastow
  • Publication number: 20030060472
    Abstract: New compounds of formula I are described: 1
    Type: Application
    Filed: June 20, 2001
    Publication date: March 27, 2003
    Inventors: David Alexander Learmonth, Patricio Manuel Vieira Araujo Soares da Silva
  • Publication number: 20030022930
    Abstract: This invention provides compounds of the formula: 1
    Type: Application
    Filed: June 27, 2002
    Publication date: January 30, 2003
    Applicant: Wyeth
    Inventors: Gary Paul Stack, John Dunlop, Alexander Alexei Greenfield, Jonathan Laird Gross
  • Patent number: RE40901
    Abstract: A novel taxane derivative with anticancer activity, a process for its preparation and a process for the preparation of 14-?-hydroxy-1,14-carbonate-baccatine III and V derivatives 13-substituted by an isoserine residue.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: September 1, 2009
    Assignee: Indena S.p.A.
    Inventors: Ezio Bombardelli, Bruno Gabetta, Alessandro Pontiroli