Plural Ring Oxygens In The Hetero Ring Patents (Class 549/430)
  • Publication number: 20150141668
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: January 26, 2015
    Publication date: May 21, 2015
    Applicant: Eastman Chemical Company
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Patent number: 9029577
    Abstract: The present invention relates to a novel method for preparing methylene-1,3-dioxolanes of the general formula (I) in which R1 and R2 have the meanings stated in the description. Methylene-1,3-dioxolanes are important intermediates for preparing pyrazoles and anthranilic acid amides, which may be used as insecticides.
    Type: Grant
    Filed: January 30, 2013
    Date of Patent: May 12, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Sergii Pazenok, Albert Schnatterer
  • Publication number: 20150113860
    Abstract: The object of the present invention relates to a composition that can be used as fuel comprising: at least one hydrocarbon mixture at least one hydrophobic ketal or acetal of glycerine. Said composition can be advantageously used as fuel for diesel or gasoline engines.
    Type: Application
    Filed: April 3, 2013
    Publication date: April 30, 2015
    Applicant: ENI S.p.A.
    Inventors: Alberto De Angelis, Giulio Assanelli, Paolo Pollesel
  • Patent number: 8969598
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: March 3, 2015
    Assignee: Eastman Chemical Company
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20140378690
    Abstract: The present invention relates to a novel method for preparing methylene-1,3-dioxolanes of the general formula (1) in which R1 and R2 have the meanings stated in the description. Methylene-1,3-dioxolanes are important intermediates for preparing pyrazoles and anthranilic acid amides, which may be used as insecticides.
    Type: Application
    Filed: January 30, 2013
    Publication date: December 25, 2014
    Inventors: Sergii Pazenok, Albert Schnatterer
  • Publication number: 20140357875
    Abstract: Cyclic acetals can be produced in a reactive distillation apparatus by combining a polyhydroxyl compound and an aldehyde. High concentrations of cyclic acetals are removed as liquid products from the column while water is removed as an overhead vapor stream.
    Type: Application
    Filed: August 14, 2014
    Publication date: December 4, 2014
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Damon Ray Billodeaux, Robert Scott Huss, Daniel Latham Terrill, Jerome Leonard Stavinoha, JR.
  • Publication number: 20140330029
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 6, 2014
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Patent number: 8829207
    Abstract: Cyclic acetals can be produced in a reactive distillation apparatus by combining a polyhydroxyl compound and an aldehyde. High concentrations of cyclic acetals are removed as liquid products from the column while water is removed as an overhead vapor stream.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: September 9, 2014
    Assignee: Eastman Chemical Company
    Inventors: Damon Ray Billodeaux, Robert S. Huss, Daniel Latham Terrill, Jerome Leonard Stavinoha, Jr.
  • Patent number: 8669382
    Abstract: In the presence invention, a (2R)-2-fluoro-2-C-methyl-D-ribono-?-lactone precursor is produced in the form of a ring-opened fluorinated compound by reaction of a 1,2-diol with sulfuryl fluoride (SO2F2) in the presence of an organic base and, optionally, a fluoride ion source. The production method of the present invention secures less number of process steps as compared to the conventional production method (shortening of three steps: cyclic sulfurous esterification, oxidation and ring-opening fluorination to one step) and satisfies the requirements for industrial production (high yield and high reproductivity). The thus-obtained (2R)-2-fluoro-2-C-methyl-D-ribono-?-lactone precursor is useful as an important intermediate for the synthesis of 2?-deoxy-2?-fluoro-2?-C-methylcytidine with antivirus activity.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: March 11, 2014
    Assignee: Central Glass Company, Limited
    Inventors: Akihiro Ishii, Hirokatsu Nagura, Hideyuki Tsuruta
  • Patent number: 8513443
    Abstract: The present invention relates to the preparation of (R)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide and (S)—N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide.
    Type: Grant
    Filed: July 10, 2010
    Date of Patent: August 20, 2013
    Assignee: Ardea Biosciences, Inc.
    Inventors: Andreas Maderna, Jean-Michel Vernier
  • Patent number: 8497064
    Abstract: Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a nucleic acid, either terminally or internally, to provide a mechanism of nucleic acid detection.
    Type: Grant
    Filed: November 1, 2011
    Date of Patent: July 30, 2013
    Assignee: Affymetrix, Inc.
    Inventors: Glenn H. McGall, Anthony D. Barone
  • Patent number: 8466196
    Abstract: The present invention relates to the field of perfumery. More particularly, it concerns some acetal derivatives of 3-methyl citral of formula (I) wherein the dotted lines indicate the presence of a single or double bond; R1 represents a hydrogen atom or a methyl or ethyl group, R2 represents a hydrogen atom or methyl group; and each R3, taken alone, simultaneously or independently, represents a C1-3 alkyl or alkenyl group; or said R3 groups, taken together, represent a C2-6 hydrocarbon group optionally comprising an oxygen atom. The present invention concerns the use of said compounds in the perfumery industry as well as the compositions or articles containing said compounds.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: June 18, 2013
    Assignee: Firmenich SA
    Inventor: George Lem
  • Publication number: 20130096322
    Abstract: A method of production of value-added, biobased chemicals, derivative products, and/or purified glycerin from bioglycerin of recycled oil, grease, and/or fat origin is described herein. A method of purification of bioglycerin of recycled oil, grease, and/or fat origin is also described herein. The method of purification of bioglycerin of recycled oil, grease, and/or fat origin described provides methods for desalinating, decolorizing, and/or concentrating bioglycerin of recycled oil, grease, and/or fat origin for the production of biobased chemicals, derivative products, and/or purified glycerin.
    Type: Application
    Filed: January 12, 2012
    Publication date: April 18, 2013
    Applicant: THESIS CHEMISTRY, LLC
    Inventors: John R. Peterson, Christopher M. Yost
  • Publication number: 20120329696
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: May 24, 2012
    Publication date: December 27, 2012
    Inventors: Hugo Robert Germain Denutte, Johan Smets, An Pintens, Jeanne Alfons Van Aken, Freek Annie Camiel Vrielynck
  • Publication number: 20120330032
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction zone at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a solid acid such as an acidic ion exchange resin, to generate a liquid reaction mixture without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid reaction mixture from the reaction zone as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds to the reaction zone. The process produces cyclic acetal compounds in yields of at least 90% with long catalyst life. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20120330033
    Abstract: A process for making a cyclic compounds such as cyclic acetal or cyclic ketones by feeding aldehyde or ketone compounds and polyhydroxyl compounds to a reaction vessel at a molar ratio of polyhydroxyl compounds to aldehyde or ketone compounds of at least 3:1, reacting these compounds in the presence of a homogeneous acid catalyst to generate a liquid phase homogeneous reaction mixture containing the acid catalyst without separating water from the reaction mixture as it is being formed in the reaction mixture, withdrawing the liquid phase homogeneous reaction mixture from the reaction vessel as a liquid product stream, and feeding the liquid reaction product stream to a distillation column to separate cyclic acetal compounds from unreacted polyhydroxyl compounds, and optionally recycling back the unreacted polyhydroxyl compounds and/or acid catalyst to the reaction vessel. The process produces cyclic acetal compounds in high yields. The process is also suitable to make cyclic ketals from ketone compounds.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Daniel Latham Terrill, Brian David McMurray, Damon Ray Billodeaux, James Lon Little, Adam Scott Howard
  • Publication number: 20120330034
    Abstract: Cyclic acetals can be produced in a reactive distillation apparatus by combining a polyhydroxyl compound and an aldehyde. High concentrations of cyclic acetals are removed as liquid products from the column while water is removed as an overhead vapor stream.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 27, 2012
    Applicant: EASTMAN CHEMICAL COMPANY
    Inventors: Damon Ray Billodeaux, Robert S. Huss, Daniel Latham Terrill, Jerome Leonard Stavinoha, JR.
  • Publication number: 20120308486
    Abstract: The present invention primarily relates to the use of dioxolanes of the following Formula (I) as fragrance and/or flavoring substances, certain perfume and/or flavoring compositions comprising these dioxolanes and corresponding perfumed and/or flavored items. The present invention also relates to a method for producing the dioxolanes of Formula (I) and certain new dioxolanes according to Formula (I).
    Type: Application
    Filed: May 16, 2012
    Publication date: December 6, 2012
    Applicant: SYMRISE AG
    Inventors: Emilie Singer, Bernd Hölscher
  • Patent number: 8222435
    Abstract: The present invention relates to novel acylmethylene-1,3-dioxolanes and acylmethylene-1,4-dioxanes of the general formula (I) in which R1, R2, R3 and n have the meanings given in the description, and also a novel process for their preparation. Acylmethylene-1,3-dioxolanes and acylmethylene-1,4-dioxanes are important intermediates for the preparation of pyrazoles and anthranilamides, which can be used as insecticides.
    Type: Grant
    Filed: December 15, 2010
    Date of Patent: July 17, 2012
    Assignee: Bayer CropScience AG
    Inventors: Sergii Pazenok, Norbert Lui, Igor Gerus, Olga Balabon
  • Publication number: 20120172453
    Abstract: This invention relates to the 5-cis and 5-trans isomers of geranylgeranyl acetone, preferably such synthetic isomers, and pharmaceutical compositions containing such isomers. Other aspects of this invention relate to the use of geranylgeranyl acetone and its isomers in methods for inhibiting neural death, increasing neural activity, and increasing axon growth and cell viability. Geranylgeranyl acetone is a known anti-ulcer drug used commercially and in clinical situations. GGA has also been shown to exert cytoprotective effects on a variety of organs, such as the eye, brain, and heart.
    Type: Application
    Filed: August 31, 2011
    Publication date: July 5, 2012
    Inventors: Ben A. Barres, Naoki Nakayama, Hiroaki Serizawa, Ankush B. Argade
  • Patent number: 8211612
    Abstract: A method for forming a protective film of a fluorine-containing polymer composition excellent in smoothness and adhesiveness on a photoresist. Moreover, there is provided a means for removing the protective film without impairing the underlying photoresist. A polymer coating composition obtainable by dissolving a fluorine-containing polymer compound in a solvent comprising a fluorinated acetal having a specific structure is applied on a photoresist and dried to form a protective film. A fluorinated acetal having the specific structure is suitable as a solvent for being brought into contact with a fluorine-containing polymer film, peeling the film, and forming a photoresist or a lithographic pattern.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: July 3, 2012
    Assignee: Central Glass Company, Limited
    Inventors: Kazuhiko Maeda, Mitsutaka Otani, Haruhiko Komoriya, Takeo Komata, Shinya Akiba
  • Publication number: 20120164576
    Abstract: A cyclic compound represented by formula (1): wherein L, R1, R?, and m are as defined in the specification. The cyclic compound of formula (1) is highly soluble to a safety solvent, highly sensitive, and capable of forming resist patterns with good profile. Therefore, the cyclic compound is useful as a component of a radiation-sensitive composition.
    Type: Application
    Filed: August 30, 2010
    Publication date: June 28, 2012
    Applicant: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Hiromi Hayashi, Masatoshi Echigo, Dai Oguro
  • Patent number: 8158564
    Abstract: A compound which satisfies requirements for the annealing property and the lubricating property simultaneously and a process for producing the compound are provided. The compound is an alkylacetal compound represented by the following general formula (1) or (2). In the general formulae, R1 and R2 represent hydrocarbon groups, R3 to R8 represent hydrogen atom or hydrocarbon groups, i and j represent integers satisfying the relation that the sum of the integers is 8 to 98, and k represents 0 or 1.
    Type: Grant
    Filed: April 9, 2009
    Date of Patent: April 17, 2012
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Haruhito Sato, Akihiro Shishikura
  • Publication number: 20120022276
    Abstract: The invention relates to a method for producing aldehyde functional compounds by a cross-metathesis reaction of an olefinic compound having at least one hydroxy group and at least one C—C double bond with at least one at least monounsaturated fatty acid or at least one at least monounsaturated fatty acid derivative, in the presence of a metathesis catalyst at a maximum temperature of 180° C. and in the presence of at least one reagent that acts as a protective group-forming compound in relation to the aldehyde group of the aldehyde functional compounds.
    Type: Application
    Filed: January 12, 2010
    Publication date: January 26, 2012
    Applicant: EVONIK DEGUSSA GmbH
    Inventors: Michael A.R. Meier, Anastasiya Rybak, Dominik Geisker, Peter Hannen, Martin Roos
  • Publication number: 20120010114
    Abstract: Acetal derivatives of 2,2,3,6-tetramethyl-1-cyclohexane/ene-carbaldehyde of formula (I): for use in the perfumery industry as well as the resulting compositions or articles containing one or more of these compounds. In formula (I), one dotted line indicates the presence of a carbon-carbon single or double bond and the other dotted line indicates the presence of a carbon-carbon single bond, R1 represents a hydrogen atom or a methyl or ethyl group; and each R, taken alone, simultaneously or independently, represents a C1-3 alkyl or alkenyl group, or the R groups, taken together, represent a C2-6 hydrocarbon group optionally including an oxygen atom.
    Type: Application
    Filed: April 14, 2010
    Publication date: January 12, 2012
    Inventors: Philippe Dupau, Murielle Haldimann Sanchez
  • Publication number: 20110308555
    Abstract: The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.
    Type: Application
    Filed: June 22, 2011
    Publication date: December 22, 2011
    Inventors: Johan SMETS, Hugo Robert Germain Denutte, An Pintens, Koen Van Aken, Freek Annie Camiel Vrielynck
  • Patent number: 8044080
    Abstract: The present invention relates to an isoxazoline derivative having the cyclic carboxylic acid hemiketal moiety of formula (1) for use as caspase inhibitor, a process for preparing it, and a pharmaceutical composition comprising it.
    Type: Grant
    Filed: February 21, 2006
    Date of Patent: October 25, 2011
    Assignee: LG Life Sciences Ltd.
    Inventors: Hyun Ik Shin, Hyeong Wook Choi, Tae Ho Heo, Kyu Woong Lee, Jae Hoon Lee, Ki Sook Park
  • Patent number: 8039524
    Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: October 18, 2011
    Assignee: SurModics, Inc.
    Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Pam Read, legal representative, Dale G. Swan, Peter H. Duquette
  • Publication number: 20110243868
    Abstract: The present invention relates to the field of perfumery. More particularly, it concerns some acetal derivatives of 3-methyl citral of formula (I) wherein the dotted lines indicate the presence of a single or double bond; R1 represents a hydrogen atom or a methyl or ethyl group, R2 represents a hydrogen atom or methyl group; and each R3, taken alone, simultaneously or independently, represents a C1-3 alkyl or alkenyl group; or said R3 groups, taken together, represent a C2-6 hydrocarbon group optionally comprising an oxygen atom. The present invention concerns the use of said compounds in the perfumery industry as well as the compositions or articles containing said compounds.
    Type: Application
    Filed: November 12, 2009
    Publication date: October 6, 2011
    Inventor: George Lem
  • Publication number: 20110200848
    Abstract: Redox flow devices are described in which at least one of the positive electrode or negative electrode-active materials is a semi-solid or is a condensed ion-storing electroactive material, and in which at least one of the electrode-active materials is transported to and from an assembly at which the electrochemical reaction occurs, producing electrical energy. The electronic conductivity of the semi-solid is increased by the addition of conductive particles to suspensions and/or via the surface modification of the solid in semi-solids (e.g., by coating the solid with a more electron conductive coating material to increase the power of the device). High energy density and high power redox flow devices are disclosed. The redox flow devices described herein can also include one or more inventive design features. In addition, inventive chemistries for use in redox flow devices are also described.
    Type: Application
    Filed: December 16, 2010
    Publication date: August 18, 2011
    Applicants: Massachusetts Institute of Technology, 24-M Technologies, Inc.
    Inventors: Yet-Ming Chiang, W. Craig Carter, Bryan Y. Ho, Mihai Duduta, Pimpa Limthongkul
  • Patent number: 7956087
    Abstract: The present invention is to provide skin cosmetics and anti-wrinkle agents which are excellent in reducing effect on wrinkle caused by photoaging. Skin cosmetics and anti-wrinkle agents which comprise a sugar alcohol derivative represented by the following formula (1): (wherein n is 1 to 5, preferably n=2.).
    Type: Grant
    Filed: April 12, 2006
    Date of Patent: June 7, 2011
    Assignee: Kao Corporation
    Inventors: Kyoko Miura, Akinori Haratake
  • Patent number: 7790909
    Abstract: Provided are a novel compound which improves the solubility of any one of various lubricating oil additives when used as base oil, in particular, a base oil component in a lubricating oil composition, and is capable of realizing low viscosity/low volatility characteristics that have not been achieved in PAO compositions to which conventional additives are added, and a method for producing the compound. Disclosed is 2-alkyl-4,4-dialkyl-1,3-dioxolane having a structure represented by the general formula (I) below: wherein R1 to R4 each independently represent an alkyl group having 1 to 30 carbon atoms.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: September 7, 2010
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventors: Haruhito Sato, Takuji Okamoto
  • Patent number: 7754900
    Abstract: Processes comprising: providing a reactive distillation column having an upper region, a middle region and a lower region; feeding ethylene glycol and an aqueous formaldehyde solution into the reactive distillation column in the middle region of the reactive distillation column; reacting the ethylene glycol and the aqueous formaldehyde solution in the reactive distillation column in the presence of a catalyst to form dioxolane; removing a product stream comprising dioxolane in an amount of at least 75% by weight from the upper region of the reactive distillation column; and removing a bottom stream comprising one or more components having boiling points higher than dioxolane from the lower region of the reactive distillation column.
    Type: Grant
    Filed: September 6, 2006
    Date of Patent: July 13, 2010
    Assignee: BASF SE
    Inventors: Markus Siegert, Neven Lang, Eckhard Stroefer, Achim Stammer
  • Patent number: 7736689
    Abstract: A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate.
    Type: Grant
    Filed: August 29, 2007
    Date of Patent: June 15, 2010
    Assignee: Surmodics, Inc.
    Inventors: Ralph A. Chappa, Sean M. Stucke, Richard A. Amos, Terrence P. Everson, Stephen J. Chudzik, Dale G. Swan, Peter H. Duquette
  • Patent number: 7671088
    Abstract: Etoposide analogs with improved water-solubility such as 4?-O-Demethyl-4?-(N?,N?-dimethyl-glycyl)-4?-(4?-nitroanilino)-4-desoxy-podophyllotoxin (8) and 4?-O-Demethyl-4?-(N?,N?-dimethyl-glycyl)-4?-(4?-fluoroanilino)-4-desoxy-podophyllotoxin (9) are described, along with pharmaceutical formulations containing the same, methods of use thereof, and intermediates and methods of making the same.
    Type: Grant
    Filed: January 3, 2007
    Date of Patent: March 2, 2010
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Kuo-Hsiung Lee, Zhiyan Xiao, Kenneth F. Bastow
  • Patent number: 7652172
    Abstract: This invention provides a practical synthesis route for 4,5-dihydroxypentane-2,3-dione (DPD), an unstable small molecule which is proposed to be the source of universal signaling agents for quorum sensing in bacteria. The synthesis route includes new intermediates and allows preparation of isotopically-labeled DPD and ent-DPD. The method provides sufficient quantities of DPD for study of spontaneous binding of borate to DPD, the signal for the marine bacteria V. harveyi.
    Type: Grant
    Filed: September 20, 2005
    Date of Patent: January 26, 2010
    Assignee: The Trustees of Princeton University
    Inventors: Martin F. Semmelhack, Shawn R. Campagna, Bonnie L. Bassler, Michael J. Federle
  • Publication number: 20090291923
    Abstract: The invention provides novel trioxane dimers having formulae III, IV or V: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer and/or malaria using these compounds and compositions.
    Type: Application
    Filed: November 17, 2006
    Publication date: November 26, 2009
    Applicants: Johns Hopkins Universoty, The Government of the United States of America as Represented by the Secretary of the DHHS NIH, Offi
    Inventors: Gary H. Posner, Ikhyeon Paik, Kristina Borstnik, Wonsuk Chang, Sandra Sinishtaj, William Malo, John Gaetano D'Angelo, Lauren Elaine Woodard, Alvin Solomon Kalinda, Aimee R. Usera, Lindsey Catherine Hess, Andrew Scott Rosenthal, Seongho Oh, Astrid C. Baege
  • Patent number: 7622616
    Abstract: A process for obtaining vinyl compounds by dehalogenation of halofluorinated compounds having a linear, branched or cyclic structure, said halofluorinated compounds containing in the molecule at least one group: wherein Y1 and Y2, equal to or different from each other, are selected from Cl, Br, I; wherein the halofluorinated compounds are dehalogenated in the presence of a transition metal, or of transition metal couples, by operating in a biphasic system of solvents immiscible among each other, formed of a (per)fluorinated solvent and a dipolar aprotic or protic solvent (co-solvent), wherein the ratio moles co-solvent/equivalents of the halofluorinated compound ranges from 0.5 to 10, preferably from 0.5 to 5, still more preferably from 1 to 3.
    Type: Grant
    Filed: May 4, 2006
    Date of Patent: November 24, 2009
    Assignee: Solvay Solexis S.p.A.
    Inventors: Ivan Wlassics, Vito Tortelli
  • Patent number: 7585891
    Abstract: Certain novel (dihalopropenyl)phenylalkyl substituted benzodioxolane and benzodioxane derivatives have provided unexpected insecticidal activity. These compounds are represented by formula I: where R through R10, inclusively, x, A, B, y, D, E, G and M are fully described herein. Preferred compounds of the present invention are those wherein the benzofused ring moiety is attached to the remainder of the molecule at the positions designated as 1- or 2-. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula I, and optionally, an effective amount of at least one of a second compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: September 8, 2009
    Assignee: FMC Corporation
    Inventors: George Theodoridis, Edward J. Barron, Dominic P. Suarez, Y. Larry Zhang, Ping Ding, John W. Lyga, Matthew P. Whiteside, Frank J. Zawacki
  • Patent number: 7576125
    Abstract: A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 3 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 3 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a high melanogenesis-inhibiting effect; and a skin preparation containing the melanogenesis inhibitor is very stable, safe, and has a sufficient fair skin effect and a sufficient effect for curing skin dyspigmentation.
    Type: Grant
    Filed: February 12, 2004
    Date of Patent: August 18, 2009
    Assignee: Takasago International Corporation
    Inventors: Kenya Ishida, Eiko Tamai
  • Patent number: 7560598
    Abstract: Cyclic ethers or chloroketones useful as fragrance components or intermediates are made by reacting a saturated, tertiary terpene alcohol with hypochloric acid under conditions effective to promote oxidation. trans-Pinanol gives predominantly 6,9-dimethyl-7-oxatricyclo[4.3.0.03,9]-nonane, while cis-pinanol yields almost exclusively 1-acetyl-3-(2-chloroethyl)-2,2-dimethylcyclobutane, a new and versatile intermediate for making cyclobutane derivatives having interesting and diverse aromas.
    Type: Grant
    Filed: April 7, 2006
    Date of Patent: July 14, 2009
    Assignee: Millennium Specialty Chemicals, Inc.
    Inventors: Bernard J. Kane, Mark B. Erman
  • Patent number: 7468243
    Abstract: Nucleic acid labeling compounds are disclosed having the formula: These compounds are useful for attaching a detectable label to a nucleic acid.
    Type: Grant
    Filed: March 12, 2002
    Date of Patent: December 23, 2008
    Assignee: Affymetrix, Inc.
    Inventors: Glenn McGall, Anthony D. Barone
  • Publication number: 20080262032
    Abstract: The present invention relates to an isoxazoline derivative having the cyclic carboxylic acid hemiketal moiety of formula (1) for use as caspase inhibitor, a process for preparing it, and a pharmaceutical composition comprising it.
    Type: Application
    Filed: February 21, 2006
    Publication date: October 23, 2008
    Inventors: Hyun Ik Shin, Hyeong Wook Choi, Tae Ho Heo, Kyu Woong Lee, Jae Hoon Lee, Ki Sook Park
  • Publication number: 20080255376
    Abstract: Processes comprising: providing a reactive distillation column having an upper region, a middle region and a lower region; feeding ethylene glycol and an aqueous formaldehyde solution into the reactive distillation column in the middle region of the reactive distillation column; reacting the ethylene glycol and the aqueous formaldehyde solution in the reactive distillation column in the presence of a catalyst to form dioxolane; removing a product stream comprising dioxolane in an amount of at least 75% by weight from the upper region of the reactive distillation column; and removing a bottom stream comprising one or more components having boiling points higher than dioxolane from the lower region of the reactive distillation column.
    Type: Application
    Filed: September 6, 2006
    Publication date: October 16, 2008
    Inventors: Markus Siegert, Neven Lang, Eckhard Stroefer, Achim Stammer
  • Publication number: 20080234152
    Abstract: A compound which satisfies requirements for the annealing property and the lubricating property simultaneously and a process for producing the compound are provided. The compound is an alkylacetal compound represented by the following general formula (1) or (2). In the general formulae, R1 and R2 represent hydrocarbon groups, R3 to R8 represent hydrogen atom or hydrocarbon groups, i and j represent integers satisfying the relation that the sum of the integers is 8 to 98, and k represents 0 or 1.
    Type: Application
    Filed: February 22, 2005
    Publication date: September 25, 2008
    Applicant: Idemitsu Kosan Co., Ltd.
    Inventors: Haruhito Sato, Akihiro Shishikura
  • Patent number: 7354893
    Abstract: An acetal of formula I: is described in which the radicals R1 to R6 independently of one another are eac hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl or tert-butyl, n=0 or 1, and there is a single bond or double bond at the location of a broken line between two C atoms, any double bond present in the chain linking the aliphatic ring to the acetal group having the E or Z configuration, with the proviso that the number of double bonds incorporating a C atom of the aliphatic ring is 0 or 1, and the number of double bonds not incorporating a C atom of the aliphatic ring is 0 or 1.
    Type: Grant
    Filed: July 5, 2004
    Date of Patent: April 8, 2008
    Assignee: Symrise GmbH & Co., KG
    Inventor: Erich Dilk
  • Patent number: 7321052
    Abstract: A process for the preparation of a fuel oil (diesel fuel or heating oil) composition which is a mixture of an alkanol tranesterified fatty acid ester triglyceride and an acetal of glycerol is described. The process preferably provides a prestep of the formation of at least some of the alkanol transesterified triglyceride containing the glycerol for use in the formation of the acetal of glycerol. The composition can also be formed from a reaction of 1,1-dimethoxy- or 1,1-diethoxyethane and glycerol to form the acetal in the alkanol transesterified triglyceride.
    Type: Grant
    Filed: February 28, 2006
    Date of Patent: January 22, 2008
    Assignee: Board of Trustees of Michigan State University
    Inventors: Dennis J. Miller, Lars Peereboom, Aspi K. Kolah, Navinchandra S. Asthana, Carl T. Lira
  • Patent number: 7252784
    Abstract: The present invention relates to a cyclic ketone peroxide formulation comprising one or more crystallizing cyclic ketone peroxides, one or more co-crystallizing compounds which solidify in said cyclic ketone peroxide formulation at a temperature above the crystallization temperature of the crystallizing cyclic ketone peroxide, and, optionally, one or more conventional phlegmatizers (diluents). These formulations show improved safety and storage stability compared to conventional cyclic ketone peroxide formulations. The invention also pertains to the use of these formulations in (co)polymerization and (co)polymer modification processes.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: August 7, 2007
    Assignee: Akzo Nobel N.V.
    Inventors: Bart Fischer, John Meijer, Rolf Hendrik Van Den Berg, Johan Nuysink
  • Patent number: 7176324
    Abstract: The present invention relates to hexahydroindan acetal and ketal compounds and their use as fragrance chemicals suitable for incorporation in fine fragrances, cosmetics, toiletries and related applications.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: February 13, 2007
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Anthony T. Levorse, Jr., Brett D. Newirth, Margaux Des Jardins, Robert P. Belko, Michael G. Monteleone
  • Patent number: 7166622
    Abstract: Compounds of Formula I, wherein R1–R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer's Disease and Down's syndrome are described.
    Type: Grant
    Filed: June 9, 2003
    Date of Patent: January 23, 2007
    Assignees: Wyeth, ArQule, Inc.
    Inventors: Anthony Frank Kreft, Derek Cecil Cole, Kevin Roger Woller, Joseph Raymond Stock, Kristina Martha Kutterer, Dennis Martin Kubrak, Charles William Mann, William Jay Moore, David Scott Casebier