Plural -c(=x)x- Groups Bonded Directly To The Hetero Ring Patents (Class 549/485)
-
Publication number: 20080182944Abstract: New polyols; oligomers, and polymers made from the polyols; and binders made from the new polyols, oligomers, or polymers that can be used in binders, where the binders typically include one or more polyols, and a polyfunctional acid or a polyfunctional nitrile.Type: ApplicationFiled: January 16, 2008Publication date: July 31, 2008Inventors: Herman P. Benecke, Daniel B. Garbark, Alex W. Kawczak, Michael C. Clingerman
-
Publication number: 20070232815Abstract: A method for producing furan-2,5-dicarboxylic acid (FDCA) is provided which can efficiently and quantitatively producing FDCA under mild conditions, without employing an expensive catalyst and with a reduced energy consumption. A furan ring compound having two functional groups selected from a hydroxymethyl group, a formyl group and a carboxyl group in the 2- and 5-positions of the furan ring, is oxidized with a metal permanganate in an alkaline environment to produce furan-2,5-dicarboxylic acid. Advantageously, the alkaline environment contains at least one of alkali metal hydroxides and alkali earth metal hydroxides, and the oxidation is performed at a temperature of from 1 to 50° C. by adding the permanganate metal salt to the alkaline aqueous solution containing the furan ring compound.Type: ApplicationFiled: March 7, 2007Publication date: October 4, 2007Applicant: CANON KABUSHIKI KAISHAInventors: Toshinari Miura, Hirokazu Kakinuma, Takenobu Kawano, Hirohide Matsuhisa
-
Patent number: 7019024Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.Type: GrantFiled: January 9, 2001Date of Patent: March 28, 2006Assignee: Allelix Neuroscience Inc.Inventors: Vassil Iliya Ognyanov, Laurence A. Borden, Stanley Charles Bell, Jing Zhang
-
Patent number: 6960594Abstract: A novel compound which inhibits certain integrins, particularly ?v integrins. Additionally, the novel compound may be used in a method of treating tumors or cancer which comprises administering a pharmaceutically effective amount of the compound to a patient. Additionally, the novel compound may be used in a method of inhibiting angiogensis. Finally, a method of producing the novel compound is disclosed.Type: GrantFiled: January 16, 2002Date of Patent: November 1, 2005Assignee: Shire BioChem Inc.Inventors: Denis Labrecque, Serge Lamothe, Marc Courchesne, Laval Chan, Giorgio Attardo, Karen Meerovitch
-
Patent number: 6380245Abstract: The present invention relates to novel antibiotics TKR1912-I having the following formula I and TKR1912-II having the following formula II or pharmacologically acceptable salts thereof, which are useful as a remedy for fungal infections, as well as a process for producing them and a microorganism capable of producing them.Type: GrantFiled: April 14, 2000Date of Patent: April 30, 2002Assignee: Takara Shuzo Co., Ltd.Inventors: Takesako Kazutoh, Yoshie Yoshikawa, Eiko Koyama, Tomoko Masuda, Ikunoshin Kato
-
Patent number: 5510402Abstract: The novel compounds of the formula I ##STR1## in which n is an integer from the range from 4 to 8 and m is an integer from the range from 1 to 4,A is the aliphatic, aromatic, araliphatic or heterocyclic radical of a monobasic to tetrabasic carboxylic acid, andR.sup.1 and R.sup.1', independently of one another, are C.sub.1 -C.sub.24 alkyl or C.sub.5 -C.sub.8 cycloalkyl, are suitable for stabilizing organic material against thermal, oxidative or actinic degradation.Type: GrantFiled: November 24, 1993Date of Patent: April 23, 1996Assignee: Ciba-Geigy CorporationInventors: Paul Dubs, Rita Pitteloud
-
Patent number: 5439925Abstract: Di(aromatic) compounds corresponding to the following formula: ##STR1## in which: Ar represents either ##STR2## n=1 or 2 or: ##STR3## X represents a divalent radical, Z represents O, S or a divalent radical, and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent a hydrogen atom or various organic radicals, and the salts of the compounds of formula (I) when R.sub.1 is a carboxylic acid function. Use is in human and veterinary medicine and in cosmetics.Type: GrantFiled: December 16, 1993Date of Patent: August 8, 1995Assignee: Centre International de Recherches Dermatologiques Galderma (Cird Galderma)Inventors: Jean-Michel Bernardon, Willliam R. Pilgrim
-
Patent number: 5324797Abstract: A thermosetting resinous composition contains (a) a polyfunctional oxazolidinone compound and (b) a polyamine which react with one another a polyurea polymer upon heating without emitting any emanating by-product. A novel class of polyfunctional oxazolidinone compounds and an improved method for producing the same are also disclosed.Type: GrantFiled: April 26, 1993Date of Patent: June 28, 1994Assignee: Nippon Paint Co., Ltd.Inventors: Toshiyuki Ishii, Hiroyuki Nojiri, Mitsuo Yamada, Ryuzo Mizuguchi
-
Patent number: 5298634Abstract: Near-quantitative conversion of maleate to D,L-malate is rapidly secured by heating an aqueous alkaline mixture of maleate and excess of the divalent cations calcium, magnesium or mixtures thereof in a reactor at autogenous pressures and at temperatures above reflux. The simplest raw materials for the process are maleic anhydride and calcium hydroxide. The product is secured as an unusual, typically granular solid form of the divalent metal malate salt which is very useful in processes for preparing other malate salts, malic acid, or 2,2'-oxodisuccinate laundry detergent builders.Type: GrantFiled: December 10, 1987Date of Patent: March 29, 1994Assignee: The Procter & Gamble CompanyInventors: Daniel S. Connor, Herbert C. Kretschmar
-
Patent number: 5296601Abstract: A process for producing a carboxylic acid ester, which comprises reacting an organic chloride having at least one chlorine atom on its ring of a substituted or unsubstituted, aromatic or heterocyclic hydrocarbon with carbon monoxide and an amine or an alcohol in the presence of a base by using as catalysts a palladium compound and a phosphine compound represented by the general formula (V):(R).sub.2 P--X--P(R).sub.2 (V)wherein R is an alkyl group or a substituted or unsubstituted phenyl group, and X is an alkylene group having 1 to 6 carbon atoms, ##STR1## or a binaphthyl group.Type: GrantFiled: May 27, 1992Date of Patent: March 22, 1994Assignee: Nihon Nohyaku Co., Ltd.Inventors: Keiji Suto, Masaaki Kudo, Moriharu Yamamoto
-
Patent number: 5081252Abstract: A process for the preparation of aromatic carboxylic acids or their salts comprises heating carboxyl-free aromatic compounds and aromatic carboxylic acid salts whose basic structures differ from those of the aromatic compounds, or heating polycyclic aromatic compounds with three or more rings and monocyclic or bicyclic aromatic carboxylic acid salts, under carbon dioxide pressure in the presence of one or more metal compounds selected from group (a) of compounds of zinc, cadmium, and thallium and one or more compounds selected from group (b) of compounds of cesium, Group II metals, And Group IIIa metals to effect the intermolecular transfer of the carboxyl groups.Type: GrantFiled: June 5, 1989Date of Patent: January 14, 1992Assignees: Nippon Steel Corporation, Nippon Steel Chemical Co., Ltd.Inventors: Shuichi Mitamura, Yoshimi Kata, Koichi Fujishiro, Yasuhisa Tsutsumi
-
Patent number: 5055471Abstract: This invention relates to derivatives of propanoic acid of the formula ##STR1## Useful as fungicides, insecticides and miticides, to processes for preparing them, to compositions containing them, and to methods of using them to combat fungi, especially fungal infections of plants, and to kill or control insects and mites.Type: GrantFiled: November 15, 1989Date of Patent: October 8, 1991Assignee: Imperial Chemical Industries PLCInventors: Paul J. de Fraine, Anne Martin
-
Patent number: 4977283Abstract: A process for the oxidation of 5-hydroxymethylfurfural which comprises oxidizing 5-hydroxymethylfurfural in an aqueous medium with oxygen in the presence of a catalyst which contains at least one metal of the platinum group.Type: GrantFiled: July 27, 1989Date of Patent: December 11, 1990Assignee: Hoechst AktiengesellschaftInventors: Ernst I. Leupold, Matthias Wiesner, Merten Schlingmann, Knut Rapp
-
Patent number: 4792606Abstract: A process for the preparation of a dimeric aromatic acyl cyanide of the formula ##STR1## in which Ar is optionally substituted phenyl, naphthyl or hetaryl,comprising reaction an acyl halide of the formulaAr--CO--Halin whichHal is fluorine, chlorine or bromine, with an alkali metal cyanide in a two-phase system comprising water and a water-immiscible or only sparingly water-miscible aliphatic ketone, and in the presence of a phase-transfer catalyst. The products are known intermediates for pesticides.Type: GrantFiled: July 16, 1987Date of Patent: December 20, 1988Assignee: Bayer AktiengesellschaftInventors: Reinhard Lantzsch, Hermann-Dieter Krall
-
Patent number: 4746350Abstract: The invention concerns novel compounds of the formula I ##STR1## wherein: Y is selected from phenyl, furyl, thienyl and pyrrolyl rings (each optionally substituted by group X), optionally branched alkylene or alkylenethio(oxy)alkylene;X which may be the same or different are independently selected from halogen, nitro, alkyl, substituted alkyl, hydroxy, alkoxy, carboxy, alkoxycarbonyl, alkylthio, sulfamoyl, substituted sulfamoyl, amino, substituted amino and alkanoyl;R.sup.1 is selected from hydrogen, acyl and an inorganic or organic cation;R.sup.2 is selected from alkyl, substituted alkyl, alkenyl, haloalkenyl and alkynyl;R.sup.3 is selected from alkyl; andR.sup.4 is selected from hydrogen, alkyl, and alkoxycarbonyl.Type: GrantFiled: April 14, 1986Date of Patent: May 24, 1988Assignee: Imperial Chemical Industries PLCInventor: Keith G. Watson
-
Patent number: 4743617Abstract: This invention relates to novel heterocyclyl-2-propyn-1-amines which are useful as dopamine beta hydroxylase inhibitors in the treatment of hypertension.Type: GrantFiled: August 31, 1987Date of Patent: May 10, 1988Assignee: Merrell Dow Pharmaceuticals Inc.Inventors: Thomas M. Bargar, Lawrence C. Creemer, James R. McCarthy
-
Patent number: 4595693Abstract: Analogs of 2,5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared.These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, inflammation, cardiovascular disorder, asthma, lung edema, adult respiratory distress syndrome, pain, and aggregation of platelets.Type: GrantFiled: June 4, 1984Date of Patent: June 17, 1986Assignee: Merck & Co., Inc.Inventors: Tesfaye Biftu, Thomas W. Doebber, San-Bao Hwang, Thomas R. Beattie, Tsung-Ying Shen, Robert Stevenson
-
Patent number: 4563527Abstract: Amidine compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof are novel compounds and are useful as powerful anti-trypsin, anti-plasmin, anti-kallikrein and anti-thrombin agents. They are also useful as a powerful anti-complement agent.Type: GrantFiled: July 19, 1984Date of Patent: January 7, 1986Assignee: Torii & Co., Ltd.Inventors: Setsuro Fujii, Toyoo Nakayama, Shigeki Nunomura, Kimio Sudo, Shin-ichi Watanabe, Toshiyuki Okutome, Yojiro Sakurai, Masateru Kurumi, Takuo Aoyama
-
Patent number: 4417072Abstract: Substituted hydroquinone compounds of the formula ##STR1## wherein R.sub.1 to R.sub.4 are hydrogen or alkyl and Z is an aromatic ring or a group of the formula --X--Y--X--, wherein X is an aromatic ring and Y is an electron withdrawing group, are incorporated as developers into photographic materials. These materials are suitable for activation processings.Type: GrantFiled: September 29, 1981Date of Patent: November 22, 1983Assignee: Ciba-Geigy AGInventors: Stephen R. Postle, Patrick D. P. Thomas, Brian R. D. Whitear
-
Patent number: 4401673Abstract: Novel 3-(buta-1',3'-dienyl)-cyclopropane-1-carboxylic acid compounds of the formula ##STR1## wherein X.sub.1 and X.sub.2 are individually a halogen and A is selected from the group consisting of (A) benzyl optionally substituted (B) ##STR2## wherein R.sub.1 is selected from the group consisting of hydrogen and --CH.sub.3 and R.sub.2 is selected from the group consisting of aryl and --CH.sub.2 --C.tbd.CH, (C) ##STR3## wherein R.sub.3 is an aliphatic of 2 to 6 carbon atoms containing at least one carbon-carbon unsaturation, (D) ##STR4## wherein R'.sub.1 and R'.sub.2 are individually selected from the group consisting of hydrogen, halogen, alkyl of 1 to 6 carbon atoms, aryl of 6 to 10 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms and cyano and R.sub.3 has the above definition, (E) ##STR5## wherein R.sub.4 is selected from the group consisting of hydrogen, --CN, --CH.sub.3, --CONH.sub.2, --CSNH.sub.2 and --C.tbd.CH, R.sub.5 is selected from the group consisting of chlorine and --CH.sub.Type: GrantFiled: January 26, 1981Date of Patent: August 30, 1983Assignee: Roussel UclafInventors: Jacques Martel, Jean Tessier, Pierre Girault