Additional Chalcogen Attached Indirectly To The Hetero Ring By Nonionic Bonding Patents (Class 549/488)
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Publication number: 20140128625Abstract: Provided is a two-step method of producing a compound of chemical formula 1 in the presence of an alcohol solvent and a Group 3B metal catalyst or a salt thereof, comprising a first step comprising alkylation or isomerization of an aldohexose-containing substrate to obtain an intermediate, and a second step comprising dehydration of the intermediate to produce a compound of chemical formula 1. Preferably, additional solvent and/or catalyst are not added in the second step.Type: ApplicationFiled: October 29, 2013Publication date: May 8, 2014Applicant: Samsung Electronics Co., Ltd.Inventors: Jong Min LEE, Hyeon Su HEO, Moo Ho LEE, Kyung Hae LEE
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Publication number: 20140121389Abstract: The invention relates to a method for preparing 5-hydroxymethylfurfural (HMF) by reacting hexose in water and in the presence of carboxylic acid. The present invention further relates to the preparation of 5-hydroxymethylfurfural (HMF) by reacting hexose in water and in the presence of carboxylic acid and of a heterogenous acid catalyst. The invention also relates to an HMF-rich carboxylic acid solution.Type: ApplicationFiled: May 16, 2012Publication date: May 1, 2014Applicants: Université Claude Bernard Lyon 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventors: Nadine Essayem, Rodrigo Lopes De Souza, Franck Rataboul
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METHOD TO CONVERT MONOSACCHARIDES TO 5-(HYDROXYMETHYL) FURFURAL (HMF) USING BIOMASS-DERIVED SOLVENTS
Publication number: 20140107355Abstract: Described is a process to produce hydroxymethyl furfural (HMF) from biomass-derived sugars. The process includes the steps of reacting a C5 and/or C6 sugar-containing reactant derived from biomass in a monophasic or biphasic reaction solution comprising water and a co-solvent. The co-solvent can be beta-, gamma-, and/or delta-lactones derived from biomass, tetrahydrofuran (THF) derived from biomass, and/or methyltetrahydrofuran (MTHF) derived from biomass. The reaction takes place in the presence of an acid catalyst and a dehydration catalyst for a time and under conditions such that at least a portion of glucose or fructose present in the reactant is converted to HMF.Type: ApplicationFiled: October 11, 2012Publication date: April 17, 2014Inventors: James A. Dumesic, Jean Marcel Ribeiro Gallo, David Alonso -
Patent number: 8697893Abstract: The present invention relates to systems and methods for producing fuels and fuel precursors from carbohydrates. In an embodiment the invention includes a method of producing 5-hydroxymethylfurfural (HMF), including contacting a saccharide with a metal oxide catalyst at a temperature of greater than about 100 degrees Celsius. In an embodiment the invention includes a method of producing a biofuel including contacting a saccharide with a metal oxide catalyst at a temperature of greater than about 100 degrees Celsius. Other embodiments are also described herein.Type: GrantFiled: December 22, 2009Date of Patent: April 15, 2014Assignee: Sartec CorporationInventors: Clayton V. McNeff, Daniel T. Nowlan
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Publication number: 20140100378Abstract: The present disclosure provides methods to produce substituted furans (e.g., halomethylfurfural, hydroxymethylfurfural, and furfural), by acid-catalyzed conversion of biomass using a gaseous acid in a multiphase reactor, such as a fluidized bed reactor.Type: ApplicationFiled: June 6, 2012Publication date: April 10, 2014Applicant: MICROMIDAS, INC.Inventors: Makoto N. Masuno, John Bissell, Ryan L. Smith, Brian Higgins, Alex Benjamin Wood, Marc Foster
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Patent number: 8642791Abstract: Described is a process to make hydroxymethylfurfural (HMF) from glucose. The process includes the steps of reacting a feedstock solution comprising glucose, in the presence of a homogeneous Brønsted acid catalyst and a homogeneous Lewis acid catalyst, in a reaction vessel containing a biphasic reaction medium. The reaction medium includes an aqueous reaction solution and a substantially immiscible organic extraction solution. HMF is produced in the aqueous reaction solution and extracted into the organic extraction solution.Type: GrantFiled: December 7, 2011Date of Patent: February 4, 2014Assignee: Wisconsin Alumni Research FoundationInventors: James A. Dumesic, Yomaira J. Pagán-Torres, Tianfu Wang, Brent Howard Shanks
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Patent number: 8642790Abstract: 5-hydroxymethylfurfural of the formula II is prepared via a 5-acyloxymethylfurfural as an intermediate.Type: GrantFiled: February 15, 2008Date of Patent: February 4, 2014Assignee: Evonik Degussa GmbHInventors: Dietmar Reichert, Martin Sarich, Friedhelm Merz
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Publication number: 20130310579Abstract: Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan.Type: ApplicationFiled: July 25, 2013Publication date: November 21, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventors: VLADIMIR GRUSHIN, Leo Ernest Manzer, Walter Partenheimer
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Publication number: 20130281719Abstract: The present invention relates to a method for efficient conversion of carbohydrates into 5-hydroxymethylfurfural (HMF) in the presence of tantalum-containing solid acid, which shows good activity and high selectivity for HMF preparation from saccharides. The catalyst is stable in aqueous system which makes it as an ideal catalyst for HMF production. High HMF yield was obtained even in mild condition. The catalysts of the invention are advantageous in that they are environment-friendly, easy separation and recovery, can be re-used in subsequent reactions, do not corrode reaction reactors. These features make the catalyst as an ideal catalyst for HMF preparation and have strong industrial application significance.Type: ApplicationFiled: November 30, 2010Publication date: October 24, 2013Applicant: Dalian Institute of Chemical Physics, Chinese Academy of SciencesInventors: Yuguang Du, Qishun Liu, Fengli Yang, Xuefang Bai, Jingmei Zhao
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Patent number: 8563756Abstract: In an embodiment of the invention, an apparatus for preparing hydroxymethylfurfural (HMF) is provided. The apparatus includes a reaction area including a first organic layer including sugar and a solvent and a second organic layer including a solvent mixture with azeotropy and extractability, a boiling area including a mixing solution formed by the hydroxymethylfurfural and the solvent mixture, connected with the reaction area, and a distilling area including water and a liquid layer including the solvent mixture, connected to the reaction area. In another embodiment of the invention, a method for preparing hydroxymethylfurfural (HMF) is provided.Type: GrantFiled: December 20, 2010Date of Patent: October 22, 2013Assignee: Industrial Technology Research InstituteInventors: Ruey-Fu Shih, Hsi-Yen Hsu
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Patent number: 8524924Abstract: Furfural is produced from a lignocellulosic feedstock comprising glucan and xylan. The feedstock is contacted with water in the presence of an acid catalyst. The resulting mixture is contacted with at least one water-immiscible organic solvent to form a mixture comprising an aqueous phase and an organic phase. Under suitable reaction conditions, furfural is produced and preferentially partitions into the organic phase, from which it may be recovered.Type: GrantFiled: December 21, 2010Date of Patent: September 3, 2013Assignee: E I du Pont de Nemours and CompanyInventors: Christopher Burket, Subramaniam Sabesan
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Patent number: 8512934Abstract: Compounds of the formula (I), wherein X is a single bond, CRaRb O, S, NRC, NCORC, CO, SO or SO2; L, L1, L2, L3, L4, L5, L6, L7 and L8 are for example hydrogen, R1 or COT; T denotes T1 or O-T2; T1 and T2 for example are hydrogen, C1-C20alkyl, C3-C12cycloalkyl, C2-C20alkenyl, C5-C12cycloalkenyl, C6-C14aryl, C3-C12heteroaryl, C1-C20alkyl substituted by one or more D, C2-C20alkyl interrupted by one or more E, C2-C20alkyl substituted by one or more D and interrupted by one or more E or Q; R1, R2, R3, R4, Ra, Rb and Rc are T1; D is for example R5, OR5, SR5 or Q1; E is for example O, S, COO or Q2; R5 and R6 for example are hydrogen, C1-C12alkyl or phenyl; Q is for example C6-C12bicycloalkyl, C6-C12bicycloalkenyl or C6-C12tricycloalkyl; Q1 is for example, C6-C14aryl or C3-C12heteroaryl; Q2 is for example C6-C14arylene or C3-C12heteroarylene; Y is an anion; and M is a cation; provided that at least one of L, L1, L2, L3, L4, L5, L6, L7 and L8 is other than hydrogen; and provided that (i) at least one of T1 or T2 is a gType: GrantFiled: September 29, 2008Date of Patent: August 20, 2013Assignee: BASF SEInventors: Pascal Hayoz, Hitoshi Yamato
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Patent number: 8501971Abstract: The subject of the present invention is a novel process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl]methanesulfonamide of formula I: and the new intermediates of the preparation process.Type: GrantFiled: May 24, 2012Date of Patent: August 6, 2013Assignee: SanofiInventors: Antal Friesz, Zsolt Dombrady, Mariann Csatarine Nagy
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Publication number: 20130190516Abstract: Disclosed are compositions and methods for the production of mono-esters and di-esters from the reaction of HMF and a reactant selected from a diacid or a diacid derivative; typical reactants are PAN, phthaloyl dichloride, dimethyl phthalate, maleic acid, and maleic anhydride or mono-esters that can be prepared from HMF and MAN.Type: ApplicationFiled: July 20, 2012Publication date: July 25, 2013Applicant: Battelle Memorial InstituteInventors: Herman Paul Benecke, Jerry L. King, II, Alex Walter Kawczak, Donald W. Zehnder, II, Erica E. Hirschl
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Publication number: 20130172580Abstract: Disclosed are processes comprising contacting an aqueous reaction mixture having an initial pH between about 3 and about 6 and comprising levoglucosenone with a catalyst, and heating the reaction mixture to form a product mixture comprising 5-hydroxymethyl-2-furfural. The processes may further comprise heating the product mixture comprising 5-hydroxymethyl-2-furfural in the presence of hydrogen and a hydrogenation catalyst to form a second product mixture comprising one or more of 2,5-furandimethanol, tetrahydrofuran 2,5-dimethanol, 1,2,6-hexanetriol, 2-hydroxymethyltetrahydropyran, and 1,6-hexanediol.Type: ApplicationFiled: December 28, 2012Publication date: July 4, 2013Applicant: E I DU PONT DE NEMOURS AND COMPANYInventor: E I DU PONT DE NEMOURS AND COMPANY
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Publication number: 20130158254Abstract: A method for converting a carbohydrate to a furan in a polar aprotic solvent in the presence of a chloride, bromide, or iodide salt or a mixture thereof and optionally in the presence of an acid catalyst, a metal halide catalyst and/or an ionic liquid (up to 40 wt %). The method can be employed in particular to produce furfural or 5-hydroxymethylfurfural.Type: ApplicationFiled: October 30, 2012Publication date: June 20, 2013Inventors: Joseph Bartholomew BINDER, Ronald Thaddeus Raines
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Publication number: 20130150595Abstract: Described is a process to make hydroxymethylfurfural (HMF) from glucose. The process includes the steps of reacting a feedstock solution comprising glucose, in the presence of a homogeneous Brønsted acid catalyst and a homogeneous Lewis acid catalyst, in a reaction vessel containing a biphasic reaction medium. The reaction medium includes an aqueous reaction solution and a substantially immiscible organic extraction solution. HMF is produced in the aqueous reaction solution and extracted into the organic extraction solution.Type: ApplicationFiled: December 7, 2011Publication date: June 13, 2013Inventors: James A. Dumesic, Yomaira J. Pagán-Torres, Tianfu Wang, Brent Howard Shanks
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Publication number: 20130150597Abstract: A process for preparing 5-hydroxymethylfurfural (HMF), which comprises a) feeding solutions (hereinafter called starting solution) comprising one or more saccharides and an organic solvent having a boiling point greater than 200° C. (at standard pressure) (called high boiler for short) and water, ?and a solvent having a boiling point greater than 60° C. and less than 200° C. (at standard pressure, called low boiler for short) to a reaction vessel, b) effecting a conversion of hexose to HMF in the reaction vessel in the presence of water vapor with simultaneous distillative removal of the HMF and c) obtaining, as the distillate, an aqueous, HMF-comprising solution (hereinafter called distillate).Type: ApplicationFiled: December 12, 2012Publication date: June 13, 2013Applicant: BASF SEInventor: BASF SE
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Publication number: 20130150596Abstract: Method for producing 5-hydroxymethylfurfural (HMF), wherein a) solutions (hereinbelow called starting solution) which comprise a hexose and an organic solvent with a boiling point greater than 200° C. (at standard pressure) (for short called high-boiling component), and steam are fed to a reaction vessel, b) in the reaction vessel, a conversion of the hexose to HMF takes place in the presence of steam with the simultaneous distillative removal of the HMF and c) as distillate, an aqueous, HMF-comprising solution (hereinbelow called distillate) is obtained.Type: ApplicationFiled: December 12, 2012Publication date: June 13, 2013Applicant: BASF SEInventor: BASF SE
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Publication number: 20130123520Abstract: Methods for the production of dehydrated sugars and derivatives of dehydrated sugars using microwave (MW) irradiation and methods of purifying the same are described. The dehydrated sugars derivatives include 5-hydroxymethyl-2-furfural (HMF) and anhydrosugar alcohols such as sorbitans and isosorbide. The derivatives include HMF ethers, levulinic acid esters, and ether derivatives of the anhydrosugar alcohols. The described methods require lower reaction temperatures and shorter reaction times than similar non microwave mediated reactions known in the art. Typical reaction conditions are 120-210° C., and typical reaction times are 30 minutes or less.Type: ApplicationFiled: July 18, 2011Publication date: May 16, 2013Applicant: Archer Daniels Midland CompanyInventors: Stephen J. Howard, Alexandra J. Sanborn
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Publication number: 20130085285Abstract: Method for the manufacture of furan compounds by using a heterogeneous catalyst in aqueous solution.Type: ApplicationFiled: September 28, 2012Publication date: April 4, 2013Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNGInventor: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERU
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Patent number: 8389749Abstract: Described is a catalytic process for converting biomass to furan derivatives (e.g., furfural, furfuryl alcohol, etc.) using a biphasic reactor containing a reactive aqueous phase and an organic extracting phase containing an alkylphenol. The process provides a cost-effective route for producing furfural, furfuryl alcohol, levulinic acid hydroxymethylfurfural, ?-valerolactone, and the like. The products formed are useful as value-added intermediates to produce polymers, as precursors to diesel fuel, and as fuel additives.Type: GrantFiled: May 25, 2011Date of Patent: March 5, 2013Assignee: Wisconsin Alumni Research FoundationInventors: James Dumesic, David Alonso, Jesse Bond, Thatcher Root, Mei Chia
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Publication number: 20130023679Abstract: A method of preparing furfural compounds and a mixture for preparing the same are disclosed. First, a solution is prepared by mixing an organic ammonium salt and a hydroxyl organic solvent. Then, a carbohydrate is mixed with the solution to form a mixture. The mixture is heated to a reaction temperature for conversion of the carbohydrate to produce the furfural compounds.Type: ApplicationFiled: October 17, 2011Publication date: January 24, 2013Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ruey-Fu Shih, Hsi-Yen Hsu, Jinn-Jong Wong
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Publication number: 20120330039Abstract: The present invention relates to a method for dehydrating a carbohydrate-comprising composition.Type: ApplicationFiled: June 21, 2012Publication date: December 27, 2012Applicant: BASF SEInventors: Alois Kindler, Klemens Massonne
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Patent number: 8338626Abstract: Method for the manufacture of 5-alkoxymethylfurfural derivatives by reacting a fructose and/or glucose-containing starting material with an alcohol in the presence of a catalytic or sub-stoechiometric amount of heterogeneous acid catalyst. The catalysts may be employed in a continuous flow fixed bed or catalytic distillation reactor. The ethers can be applied as a fuel or fuel additive.Type: GrantFiled: December 8, 2011Date of Patent: December 25, 2012Assignee: Furanix Technologies B.V.Inventors: Gerardus Johannes Maria Gruter, Frits Dautzenberg
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Publication number: 20120302765Abstract: Described is a catalytic process for converting biomass to furan derivatives (e.g., furfural, furfuryl alcohol, etc.) using a biphasic reactor containing a reactive aqueous phase and an organic extracting phase containing an alkylphenol. The process provides a cost-effective route for producing furfural, furfuryl alcohol, levulinic acid hydroxymethylfurfural, ?-valerolactone, and the like. The products formed are useful as value-added intermediates to produce polymers, as precursors to diesel fuel, and as fuel additives.Type: ApplicationFiled: May 25, 2011Publication date: November 29, 2012Inventors: James Dumesic, David Alonso, Jesse Bond, Thatcher Root, Mei Chia
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Publication number: 20120294900Abstract: Provided are compositions and methods for modulating quorum sensing in microbes. The compounds are AI-2 analogs and as such have structures similar to 4,5-dihydroxy-2,3-pentanedione that can act as agonists/antagonists of quorum sensing. The compounds are useful for modulating quorum sensing in bacteria and can be used in methods for prophylaxis or therapy of bacterial infections and for reduction of biofilms.Type: ApplicationFiled: March 26, 2012Publication date: November 22, 2012Applicant: UNIVERSITY OF MARYLAND, COLLEGE PARKInventors: Herman Sintim, William E. Bentley, Varnika Roy, Jacqueline Smith
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Patent number: 8247582Abstract: Disclosed are compositions and methods for the production of mono-esters and di-esters from the reaction of HMF and a reactant selected from a diacid or a diacid derivative; typical reactants are PAN, phthaloyl dichloride, dimethyl phthalate, maleic acid, and maleic anhydride or mono-esters that can be prepared from HMF and MAN.Type: GrantFiled: February 7, 2007Date of Patent: August 21, 2012Assignee: Battelle Memorial InstituteInventors: Herman P. Benecke, Jerry L. King, II, Alex Walter Kawczak, Donald W. Zehnder, II, Erica E. Hirschl
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Patent number: 8236973Abstract: Presently disclosed are methods and apparatus for separation of reaction products from reaction mixtures in an ionic liquid catalysis process, particularly in conversion of biomass, cellulose, and sugars into chemical intermediates such as 5-hydroxymethylfurfural (HMF). In one embodiment an ion exclusion adsorption mechanism is used for the separation process. The process comprises (i) mixing the ionic liquid-containing reaction mixture with de-ionized water, (ii) flowing the water solution mixture into an adsorption column, (iii) eluting the column with a water- and/or alcohol-based fluid, and (iv) collecting separated fractions at different elution times.Type: GrantFiled: April 8, 2010Date of Patent: August 7, 2012Assignee: Battelle Memorial InstituteInventors: Wei Liu, John E. Holladay, Feng Zheng, Heather M. Brown, Alan R. Cooper
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Patent number: 8236972Abstract: The instant invention involves a process for enhancing molecular mass of biomass reactants. The process comprises first forming a substituted or unsubstituted furfural from a biomass. The substituted or unsubstituted furfural is then reacted with an activated methylene compound in the presence of a catalyst and, if desired, a solvent to form a Knoevenagel product. The product may then be hydrogenated to products containing an alcohol, ether, aldehyde, or ketone functional groups or to an olefinic or aliphatic species wherein as much as all of the oxygen and/or nitrogen has been removed.Type: GrantFiled: July 29, 2008Date of Patent: August 7, 2012Assignee: Georgia Tech Research CorporationInventors: Travis J. C. Hoskins, Carsten Sievers, Pradeep K. Agrawal, Christopher W. Jones
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Publication number: 20120172607Abstract: A method for preparing hydroxymethylfurfural, which includes: a) mixing and dissolving triose or its derivatives and solvent 1 to obtain the first reaction mixture; b) reacting the obtained first reaction mixture with Alkaline Catalyst 1 to condense into hexose; c) mixing and dissolving the resulting hexose and solvent 2 to obtain the second reaction mixture; d) adding acid catalyst 2 to the second reaction mixture, then heating the second reaction mixture at 80˜280° C. to form the third reaction mixture including hydroxymethylfurfural; e) obtaining the hydroxymethylfurfural separating by separating from the third mixture. The method is a new synthetic way for preparing 4-hydroxymethylfurfural and 5-hydroxymethylfurfural.Type: ApplicationFiled: January 9, 2012Publication date: July 5, 2012Inventors: Yao Fu, Jin Deng, Qingxiang Guo, Jing Zhao, Lei Liu
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Publication number: 20120083610Abstract: Method for the manufacture of 5-alkoxymethylfurfural derivatives by reacting a fructose and/or glucose-containing starting material with an alcohol in the presence of a catalytic or sub-stoechiometric amount of heterogeneous acid catalyst. The catalysts may be employed in a continuous flow fixed bed or catalytic distillation reactor. The ethers can be applied as a fuel or fuel additive.Type: ApplicationFiled: December 8, 2011Publication date: April 5, 2012Applicant: FURANIX TECHNOLOGIES B.V.Inventors: Gerardus Johannes Maria Gruter, F. Dautzenberg
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Patent number: 8133289Abstract: Method for the manufacture of 5-alkoxymethylfurfural derivatives by reacting a fructose and/or glucose-containing starting material with an alcohol in the presence of a catalytic or sub-stoechiometric amount of solid (“heterogeneous”) acid catalyst. The catalysts may be employed in a continuous flow fixed bed or catalytic distillation reactor. The ethers can be applied as a fuel or fuel additive.Type: GrantFiled: March 12, 2007Date of Patent: March 13, 2012Assignee: Furanix Technologies B.V.Inventors: Gerardus Johannes Maria Gruter, Frits Dautzenberg
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Publication number: 20120053355Abstract: Disclosed is a method of preparing a petroleum-alternative bio fuel material such as 5-hydroxymethyl-2-furfural (HMF), 5-alkoxymethyl-2-furfural, levulinic acid alkil ester, etc. through a single process without saccharification, using a catalyst conversion reaction, from galactan that can be massively supplied at low costs and extracted from macroalgae of marine reusable resources. Thus, the macroalgae of the marine biomass resources is used so that a carbon source can be more easily extracted than that of a lignocellulosic biomass resource without a problem of having an effect on grain price like a crop-based biomass.Type: ApplicationFiled: April 15, 2010Publication date: March 1, 2012Applicant: KOREA INSTITUTE OF INDUSTRIAL TECHNOLOGYInventors: Jin-Ku Cho, Sang-Yong Kim, Do-Hoon Lee, Bo-Ra Kim, Jae-Won Jung
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Publication number: 20120042566Abstract: Polycarbon biofuels may be made from feedstock such as wood waste, agricultural wastes and waste paper. The feedstock may be cooked under acidic conditions to convert cellulose and similar material in the feedstock into a biofuel that is hydrophobic, readily pelletized, and has a high energy density. The biofuel may be blended with coal or other fuels to provide blended fuels that may be burned in conventional burners. One process forms a slurry of the feedstock, sparges carbon dioxide through the slurry to achieve a pH below 5 and cooks the slurry at temperatures in the range of 170 C to 300 C until conversion of the feedstock to polycarbon biofuel has occurred. The biofuel may be separated from liquids in the slurry by filtration.Type: ApplicationFiled: April 30, 2010Publication date: February 23, 2012Applicant: EVE RESEARCH INC.Inventor: Alexis Fosse Mackintosh
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Publication number: 20120016141Abstract: In an embodiment of the invention, an apparatus for preparing hydroxymethylfurfural (HMF) is provided. The apparatus includes a reaction area including a first organic layer including sugar and a solvent and a second organic layer including a solvent mixture with azeotropy and extractability, a boiling area including a mixing solution formed by the hydroxymethylfurfural and the solvent mixture, connected with the reaction area, and a distilling area including water and a liquid layer including the solvent mixture, connected to the reaction area. In another embodiment of the invention, a method for preparing hydroxymethylfurfural (HMF) is provided.Type: ApplicationFiled: December 20, 2010Publication date: January 19, 2012Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Ruey-Fu Shih, Hsi-Yen Hsu
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Publication number: 20120004430Abstract: The invention provides a process for making hydroxymethylfurfural comprising exposing a saccharide, e.g. glucose or fructose, to a metal complex of an N-heterocyclic carbene.Type: ApplicationFiled: June 18, 2008Publication date: January 5, 2012Applicant: Agency for Science, Technology and ResearchInventors: Yugen Zhang, Jackie Y. Ying
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Publication number: 20110288076Abstract: This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particularly, this disclosure relates to sphingosine-1-phosphate 1 (S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.Type: ApplicationFiled: October 16, 2009Publication date: November 24, 2011Applicant: EXELIXIS, INC.Inventors: Mohamed Abdulkader Ibrahim, Joon Won Jeong, Henry William Beecroft Johnson, Patrick Kearney, James W. Leahy, Gary L. Lewis, Robin Tammie Noguchi, John M. Nuss
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Patent number: 8058458Abstract: A method for utilizing an industrially convenient fructose source for a dehydration reaction converting a carbohydrate to a furan derivative is provided. Recovery methods also are provided. Embodiments of the methods improve upon the known methods of producing furan derivatives.Type: GrantFiled: July 13, 2009Date of Patent: November 15, 2011Assignee: Archer Daniels Midland CompanyInventor: Alexandra J. Sanborn
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Patent number: 8058273Abstract: New inhibitors of histone deacetylases having antitumor activity, and the process of preparation thereof are herein described. These compounds belong to the structural formula (I) where R1 is a linear or branched chain containing at least two conjugated double bonds, A is an optionally substituted phenyl or pyridyl ring, Ar is an aryl or heteroaryl group, and R3 is hydrogen or alkoxyalkyl. The application also describes the use of said compounds in the treatment of diseases associated to the deregulation of histone deacetylases activity, such as tumors, as well as the relevant pharmaceutical compositions for administration to patients requiring said treatment.Type: GrantFiled: June 1, 2010Date of Patent: November 15, 2011Assignee: DAC S.R.L.Inventors: Saverio Minucci, Pier Giuseppe Pelicci, Antonello Mai, Marco Ballarini, Gaetano Gargiulo, Silvio Massa
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Publication number: 20110257196Abstract: The present invention relates to novel compounds having anti-cancer activity, methods of making these compounds, and their use for treating cancer and drug-resistant tumors, e.g. melanoma, metastatic melanoma, drug resistant melanoma, prostate cancer and drug resistant prostate cancer.Type: ApplicationFiled: December 29, 2010Publication date: October 20, 2011Inventors: Yan Lu, Chien-Ming Li, Zhao Wang, Jianjun Chen, Wei Li, James T. Dalton, Duane D. Miller, Charles Duke, Sunjoo Ahn
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Patent number: 7956203Abstract: Alcohols are catalytically oxidized to aldehydes, in particular to benzaldehyde and diformylfuran, which are useful as intermediates for a multiplicity of purposes. The invention also relates to the polymerization of the dialdehyde and to the decarbonylation of the dialdehyde to furan.Type: GrantFiled: March 27, 2001Date of Patent: June 7, 2011Assignee: E. I. du Pont de Nemours and CompanyInventors: Vladimir Grushin, Walter Partenheimer, Leo E. Manzer
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Publication number: 20110130561Abstract: A method for obtaining a saccharide by lysing cellulose which is substance that is not readily lysed. Cellulose is mixed in acidic electrolyzed water, and the resulting mixture is stirred at a maximum temperature of 210° C. and at saturation vapor pressure of 1.9 MPa to obtain a saccharide.Type: ApplicationFiled: November 12, 2010Publication date: June 2, 2011Applicant: HONDA MOTOR CO., LTD.Inventor: Kohichi MIYASHITA
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Patent number: 7939681Abstract: Methods are described for converting carbohydrates including, e.g., monosaccharides, disaccharides, and polysaccharides in ionic liquids to value-added chemicals including furans, useful as chemical intermediates and/or feedstocks. Fructose is converted to 5-hydroxylmethylfurfural (HMF) in the presence of metal halide and acid catalysts. Glucose is effectively converted to HMF in the presence of chromium chloride catalysts. Yields of up to about 70% are achieved with low levels of impurities such as levulinic acid.Type: GrantFiled: July 6, 2007Date of Patent: May 10, 2011Assignee: Battelle Memorial InstituteInventors: Haibo Zhao, Johnathan E. Holladay, Zongchao C. Zhang
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Publication number: 20110082304Abstract: Method for the manufacture of 5-hydroxymethylfurfural derivatives by reacting a fructose and/or glucose-containing starting material with an alcohol in the presence of a catalytic or sub-stoichiometric amount of solid (“heterogeneous”) acid catalyst. The catalysts may be employed in a continuous flow fixed bed or catalytic distillation reactor. The ethers can be applied as a fuel or fuel additive.Type: ApplicationFiled: December 15, 2010Publication date: April 7, 2011Applicant: FURANIX TECHNOLOGIES B.V.Inventors: Gerardus Johannes Maria Gruter, F. Dautzenberg
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Publication number: 20110071306Abstract: A method is disclosed for the acid hydrolysis of carbohydrates in or from biomass, using a solvent system including an aqueous ether, where the ether form a majority of the system, which affords high yields to the platform chemicals such as 2-furfural and 5-hydroxymethylfurfural (5-HMF). The later can also undergo a domino reaction to chemicals including levulinic acid, particularly with oxygenated anions and greater water content. A total dissolution and reaction of biomass occurs under a range of relatively mild conditions (combined Severity range ˜2.2-2.6). Lignin and lignin derived products can be easily separated by precipitation.Type: ApplicationFiled: September 24, 2009Publication date: March 24, 2011Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMInventor: J. Michael Robinson
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Patent number: 7897794Abstract: Disclosed are methods of at least partially purifying HMF from an aqueous mixture containing reactants and products of HMF synthesis from fructose that relies on use of non-functional polymeric resins. A first type of non-functional polymeric resin preferentially adsorbs HMF relative to fructose and is used to remove a majority of fructose from the reaction mixture. HMF is desorbed from the first non-functional polymeric resin with an organic solvent such as acetone. A second type of non-functional polymeric resin preferential adsorbs furfural from an aqueous reaction mixture allowing HMF to pass through. In one embodiment, these non-functional polymeric resins may be used alone in combination with each other to obtain HMF of high purity. In other embodiments, one or more of the foregoing non-functional polymeric resin resins is used in combination with cation exchange chromatography to still further purify the HMF.Type: GrantFiled: June 18, 2008Date of Patent: March 1, 2011Assignee: Archer Daniels Midland CompanyInventors: Douglas F. Geier, John Glenn Soper
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Publication number: 20100297542Abstract: Compounds of the formula (I), wherein X is a single bond, CRaRb O, S, NRC, NCORC, CO, SO or SO2; L, L1, L2, L3, L4, L5, L6, L7 and L8 are for example hydrogen, R1 or COT; T denotes T1 or O-T2; T1 and T2 for example are hydrogen, C1-C20alkyl, C3-C12cycloalkyl, C2-C20alkenyl, C5-C12cycloalkenyl, C6-C14aryl, C3-C12heteroaryl, C1-C20alkyl substituted by one or more D, C2-C20alkyl interrupted by one or more E, C2-C20alkyl substituted by one or more D and interrupted by one or more E or Q; R1, R2, R3, R4, Ra, Rb and Rc are T1; D is for example R5, OR5, SR5 or Q1; E is for example O, S, COO or Q2; R5 and R6 for example are hydrogen, C1-C12alkyl or phenyl; Q is for example C6-C12bicycloalkyl, C6-C12bicycloalkenyl or C6-C12tricycloalkyl; Q1 is for example, C6-C14aryl or C3-C12heteroaryl; Q2 is for example C6-C14arylene or C3-C12heteroarylene; Y is an anion; and M is a cation; provided that at least one of L, L1, L2, L3, L4, L5, L6, L7 and L8 is other than hydrogen; and provided that (i) at least one of T1 or T2 is a gType: ApplicationFiled: September 29, 2008Publication date: November 25, 2010Applicant: BASF SEInventors: Pascal Hayoz, Hitoshi Yamato
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Publication number: 20100273835Abstract: The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the description and claims. The compounds of the present invention are useful as inhibitors of prolyl endopeptidase (PEP, EC 3.4.21.26) and/or IL-6.Type: ApplicationFiled: July 10, 2008Publication date: October 28, 2010Applicant: PROBIODRUG AGInventors: Ulrich Heiser, Andre J. Niestroj, Ingo Schulz
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Patent number: RE43327Abstract: The disclosed invention provides new polyamine analogs and derivatives containing a hydrophobic region and a polyamine region as well as methods and compositions for their use.Type: GrantFiled: January 8, 2002Date of Patent: April 24, 2012Assignee: Aminex Therapeutics, Inc.Inventors: Mark R. Burns, Gerard F. Graminski, Nand Baindur