Phosphorus Containing Patents (Class 554/78)
  • Publication number: 20100233349
    Abstract: Biomass extracts with high protein and nutritional value and methods for making the same are disclosed. Such extracts may include cakes with low residual oil and high levels of desirable constituents and oils that require little to no downstream processing upon extraction from the biomass. Also includes methods of extracting desirable products from an oil bearing biomass.
    Type: Application
    Filed: February 15, 2010
    Publication date: September 16, 2010
    Applicant: Crown Iron Works Company
    Inventors: Lon E. Smallridge, Floyd C. Teeter, JR.
  • Patent number: 7771711
    Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: August 10, 2010
    Assignees: Yissum Research Development Company of The Hebrew University of Jerusalem, Biolab Ltd.
    Inventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
  • Publication number: 20100172967
    Abstract: Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like.
    Type: Application
    Filed: February 19, 2010
    Publication date: July 8, 2010
    Applicants: KYOWA HAKKO KIRIN CO., LTD., TECHNO NETWORK SHIKOKU CO., LTD.
    Inventors: Hisao Nemoto, Masahiro Yamauchi, Hiroko Kusano, Yasuki Kato, Motoo Yamasaki, Toshiyuki Suzawa
  • Publication number: 20100160224
    Abstract: A shelf-stable consumable composition may comprise one or more Probiotic-Mimicking Elements (PMEs) wherein the median particle size of the one or more PMEs is less than the median particle size of a probiotic from which the one or more PMEs were derived. In some embodiments, the median particle size of the one or more PMEs may be less than about 0.2 microns. In some embodiments, the PMEs may comprise at least one of peptides, fatty acids, bacteriocins, cell surface proteins, phospholipids, teichoic acids, and nucleic acids, and may be combined with one or more prebiotics, such as oligosaccharides, inulin, short-chain fructo-oligosaccharides, xylooligosaccharides, galactooligosaccharides, soyoligosaccharides, and lactulose/lactitol. Methods for preparing and using a shelf-stable consumable composition for promoting digestive health in a subject are also described.
    Type: Application
    Filed: October 14, 2009
    Publication date: June 24, 2010
    Inventors: David Thomas, James Steele
  • Publication number: 20100145085
    Abstract: Methods are disclosed for extracting and separating polar lipids, including phospholipids, from materials containing oil, polar lipid, protein, ash, and/or carbohydrate, such as egg yolks and other phospholipid-containing materials. In particular, methods for extracting phospholipids from phospholipid-containing materials through the use of an aliphatic alcohol and control of temperature are disclosed. Using these methods, phospholipids in the aqueous liquid fraction will be efficiently separated and will precipitate readily, and can be subjected to separation for improved purity.
    Type: Application
    Filed: July 28, 2009
    Publication date: June 10, 2010
    Applicant: Martek Biosciences Corporation
    Inventor: Jesus Ruben Abril
  • Patent number: 7700792
    Abstract: To provide a highly active LPA and a method of screening therewith. There is provided a method of screening a preventive and/or therapeutic substance for diseases in which LPA takes part, characterized in that a compound represented by any of formula (I), (II) and (III): [wherein the meaning of characters are described in the description] is used. The compounds obtained by the screening method or the screening kit of the present invention, their salts, their solvates and prodrugs thereof would modulate the binding of highly active LPA with LPA receptor in human and other mammals, so that they can be used as a preventive and/or therapeutic agent for diseases in which LPA takes part, for example, urinary diseases, central nervous diseases, inflammatory diseases, circulatory diseases, cancer, diabetes, immune system disorders and alimentary diseases.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: April 20, 2010
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Akio Hayashi, Shinji Nakade, Hidehiro Suzuki
  • Publication number: 20100086583
    Abstract: The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.
    Type: Application
    Filed: September 2, 2009
    Publication date: April 8, 2010
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventor: Hansjörg EIBL
  • Publication number: 20100029523
    Abstract: A lubricant from plant and/or animal oils and fats; a method for producing a lubricating oil, and the oil produced thereby. The lubricant comprises a diester produced by epoxidising an animal or plant fat or oil having an iodine number above about 7 and reacting the epoxidised oil or fat with a carboxylic acid anhydride in the presence of a basic catalyst.
    Type: Application
    Filed: August 10, 2005
    Publication date: February 4, 2010
    Inventors: Herman Benecke, Bhima R. Vijayendran, Jeffrey Cafmeyer
  • Publication number: 20100018922
    Abstract: A method for processing vegetable oil miscella is provided. The method includes steps of feeding vegetable oil miscella to a conditioned polymeric microfiltration membrane, and recovering a permeate stream having a decreased weight percent of phospholipids compared with the weight percent of phospholipids provided in the miscella. The retentate stream can be further processed for the recovery of lecithin. The polymeric microfiltration membrane can be conditioned for the selective separation of phospholipids in the miscella. A method for conditioning a membrane for selective separation of phospholipids from vegetable oil miscella, and the resulting membrane, are provided. The membrane which can be conditioned can be characterized as having an average pore size of between about 0.1? and about 2?.
    Type: Application
    Filed: January 13, 2009
    Publication date: January 28, 2010
    Applicant: Cargill, Incorporated
    Inventors: Bassam Jirjis, Harapanahalli S. Muralidhara, Dennis D. Otten
  • Publication number: 20100008863
    Abstract: New targeting or therapeutic compounds which can be incorporated into a composition of gas-filled microvesicles. The invention further relates to gas-filled microvesicles for diagnostic and/or therapeutic use comprising said compounds and to their method of use. The new compounds are compounds of formula M-S-T, wherein: M represents a component capable of associating with an envelope of a gas-filled microvesicle; T represents a component comprising a targeting ligand or a therapeutic agent; and S represents a component comprising at least two bissulfone groups.
    Type: Application
    Filed: December 19, 2007
    Publication date: January 14, 2010
    Inventors: Rolf E. Swenson, Philippe Bussat, Bernard Lamy, Sibylle Pochon, Kondareddiar Ramalingam
  • Publication number: 20090326070
    Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.
    Type: Application
    Filed: April 30, 2009
    Publication date: December 31, 2009
    Applicant: COMPLEXA INC.
    Inventors: Bruce A. FREEMAN, Bruce BRANCHAUD
  • Publication number: 20090292019
    Abstract: There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.
    Type: Application
    Filed: August 3, 2009
    Publication date: November 26, 2009
    Inventor: Samuel FORTIN
  • Patent number: 7595411
    Abstract: The present invention relates to compositions comprising a water-insoluble pharmaceutically active ingredient or a substance having low water solubility, and a compound represented by Structural Formula (I): in which A is: The present invention further relates to methods of solubilizing substances of low water solubility, and methods of preparing compositions suitable for intravenous administration.
    Type: Grant
    Filed: October 21, 2004
    Date of Patent: September 29, 2009
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventor: Hans-Jörg Eibl
  • Patent number: 7592469
    Abstract: The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.
    Type: Grant
    Filed: October 1, 2003
    Date of Patent: September 22, 2009
    Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
    Inventor: Hansjoerg Eibl
  • Publication number: 20090215067
    Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.
    Type: Application
    Filed: April 27, 2009
    Publication date: August 27, 2009
    Applicant: MOLECULAR TRANSFER, INC.
    Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
  • Publication number: 20090209775
    Abstract: Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.
    Type: Application
    Filed: February 17, 2009
    Publication date: August 20, 2009
    Applicant: Vascular Biogenics Ltd.
    Inventors: Dror Harats, Jacob George, Gideon Halperin, Niva Yacov, Eti Kovalevski-Ishai
  • Publication number: 20090197839
    Abstract: Procedure for the obtaining a concentrate of the total fixed lipids of the kernels of the family Sapotaceae, genus Calocarpum, Chrysophyllum and Lucuma. The kernels (seeds removed of the endocarp), are squeezed by means of mechanical techniques that use pressure and heat, without using extractive liquids, getting a concentrate of lipidic juices (virgin) in a dry way and with their characteristic aroma. This concentrate of total fixed lipids can be fractioned in its main constituents by means of a process that consist of the emulsification of the lipids, followed by centrifugation or sedimentation, giving place to the stratification of the main constituents and their consequent separations. The main constituent consist of oils, of phospholipids and of residues glucosidic triterpenes plus of sterols fractions.
    Type: Application
    Filed: July 21, 2004
    Publication date: August 6, 2009
    Inventor: Luis De La Llata Romero
  • Patent number: 7553981
    Abstract: The subject of the present invention is new substances which are derived from naturally occurring ceramides and sphingosine and also from synthetic compounds with principally the same structure in that they represent dimers, trimers, tetramers etc., hence i.e. oligomers of the initial substances.
    Type: Grant
    Filed: June 4, 2004
    Date of Patent: June 30, 2009
    Assignee: PLT Patent and License Trading Ltd.
    Inventors: Hans Uwe Wolf, Jörg Martin Dormann
  • Patent number: 7550449
    Abstract: It is an object of the present invention to synthesize a carba cyclic phosphatidic acid derivative having a novel structure by substituting O at position sn-2 of the glycerol skeleton with CH2, and study the action of the obtained derivative to suppress cancer cell invasion. The present invention provides a compound represented by the following formula (I): wherein R represents a linear or branched alkyl group containing 1 to 30 carbon atoms, a linear or branched alkenyl group containing 2 to 30 carbon atoms, or a linear or branched alkynyl group containing 2 to 30 carbon atoms, wherein these groups may comprise a cycloalkane ring or aromatic ring; and M represents a hydrogen atom or counter cation.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: June 23, 2009
    Inventors: Kimiko Murofushi, Mutsuko Mukai, Susumu Kobayashi, Hiromu Murofushi
  • Patent number: 7524981
    Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: April 28, 2009
    Assignees: NOF Corporation, DAIICHI Pharmaceutical Co., Ltd.
    Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Publication number: 20090068697
    Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.
    Type: Application
    Filed: October 28, 2008
    Publication date: March 12, 2009
    Applicant: Echelon Biosciences Incorporated
    Inventors: Colin Ferguson, Glenn Prestwich
  • Patent number: 7495116
    Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: February 24, 2009
    Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.
    Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
  • Patent number: 7465817
    Abstract: The present invention relates to a phospholipid dreivative having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-1 or sn-2 position of the glycerol backbone, a pharmaceutical composition comprising said phospholipid, a method for preparing said phospholipid and a medicament comprising said phospholipid.
    Type: Grant
    Filed: November 20, 2003
    Date of Patent: December 16, 2008
    Assignee: Charite-Universitats Medizin Berlin
    Inventors: Kerstin Danker, Michael Mickeleit, Dieter Mueller, Werner Reutter
  • Publication number: 20080213324
    Abstract: Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.
    Type: Application
    Filed: March 3, 2008
    Publication date: September 4, 2008
    Applicant: Luna Innovations Incorporated
    Inventors: Zhiguo Zhou, Robert P. Lenk, Darren Macfarland, Kenneth L. Walker, Jing Zhang, Stephen R. Wilson
  • Publication number: 20080214849
    Abstract: The invention relates to phospholipid-like compounds having defined apolar constituents and to the use of such compounds as liposomes, active ingredients, and solubilizers.
    Type: Application
    Filed: August 29, 2007
    Publication date: September 4, 2008
    Applicant: Max-Planck-Gesellschaft Zur Foerderung Der Wissenshaften E.V.
    Inventors: Eibl Hansjorg, Thomas Hottkowitz
  • Patent number: 7420071
    Abstract: There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 to 50 carbons and optionally including an ionizable or charged group (e.g., carboxyl group or quaternary amine). Thus, there are provided surfactants having Formula I: wherein the variables are as defined herein. Further provided are methods of making thermally stable surfactants and compositions, including composites and nanocomposites, using fillers coated with the surfactants.
    Type: Grant
    Filed: May 4, 2005
    Date of Patent: September 2, 2008
    Assignee: UChicago Argonne, LLC
    Inventor: David J. Chaiko
  • Publication number: 20080145413
    Abstract: This disclosure describes structural elements that enhance fusogenicity of lipids and lipid assemblies (e.g. liposomes) with biological membranes, in particular cell membranes, and use of such structures. The elements are pH sensitive in terms of charge and hydrophilicity and undergo a polar—apolar transition when exposed to low pH.
    Type: Application
    Filed: December 19, 2006
    Publication date: June 19, 2008
    Inventors: Steffen Panzner, Christian Reinsch, Evgenios Siepi
  • Publication number: 20080145902
    Abstract: A method for the preparation of highly polyunsaturated fatty acid-containing phosphatidylserine and phosphatidic acid by phospholipase D-catalyzed transphosphatidylation of fish liver phosphatidylcholine and L-serine is disclosed.
    Type: Application
    Filed: February 15, 2008
    Publication date: June 19, 2008
    Inventors: Su Chen, Hung Kwong
  • Publication number: 20080132712
    Abstract: Disclosed is a method for the reduction of residual peroxides in vegetable oils, preferably epoxidized vegetable oils using a phosphorous compound preferably alkyl/aryl substituted phosphite compounds or hypophosphorous acid and its derivatives.
    Type: Application
    Filed: December 5, 2006
    Publication date: June 5, 2008
    Inventors: Michael G. Denoux, Ritchie Tregre, Garrett Mineo
  • Publication number: 20080113942
    Abstract: The present invention is a phosphorylcholine-containing chemical compound represented by the following formula (1) or (2). (CH3)3N+CH2CH2PO4?CH2COOH ??(1) (CH3)3N+CH2CH2PO4?CH2COONa ??(2) The object of the present invention is to provide a new phosphorylcholine-containing compound that is useful as a surface treatment agent or a source material of a surface treatment agent. Another object is to provide a manufacturing method that has a high industrial utility value.
    Type: Application
    Filed: November 28, 2005
    Publication date: May 15, 2008
    Inventors: Yukimitsu Suda, Kazuyuki Miyazawa
  • Publication number: 20080112917
    Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.
    Type: Application
    Filed: June 17, 2004
    Publication date: May 15, 2008
    Applicants: BIOLAB LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
  • Publication number: 20080103073
    Abstract: The present disclosure is directed to compounds and methods of making the compounds having the formula: where X is a functional group chosen from: and wherein R is chosen from hydrogen, n-alkyl, iso-alkyl, aryl, heterocyclic ring, and nitrogen or a sulfur containing group, and n ranges from 0 to 4.
    Type: Application
    Filed: October 31, 2006
    Publication date: May 1, 2008
    Inventor: Atanu Adhvaryu
  • Publication number: 20080103321
    Abstract: The present invention provides a continuous process for producing an oil based phosphate containing product. The continuous process includes mixing water with at least one base and an orthophosphoric acid to produce a liquid phosphate salt containing solution. This solution is then dried, granulated, and mixed with a base stock hydrocarbon to form the oil based phosphate containing product.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 1, 2008
    Applicant: EnviroFuels LLC
    Inventors: Dustin K. James, C. Edward Baxter
  • Patent number: 7351428
    Abstract: In order to form liposomes with a longer half-life in blood, use is made of defined formula (A)
    Type: Grant
    Filed: May 7, 2004
    Date of Patent: April 1, 2008
    Assignee: Max-Planck-Gesselschaft zur Forderung der Wissenschaften E.V.
    Inventor: Hans-Jörg Eibl
  • Patent number: 7309721
    Abstract: The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: December 18, 2007
    Assignee: Merck + Co., Inc.
    Inventors: Richard J. Budhu, George A. Doherty, Jeffrey J. Hale, Christopher L. Lynch, Sander G. Mills, William E. Neway, III
  • Patent number: 7303760
    Abstract: Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleavable dithiobenzyl linkage. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of mitomycin C in its original form. The linkage is stable under nonreducing conditions. The prodrug conjugate can be incorporated into liposomes for administration in vivo and release of mitomycin C in response to endogenous in vivo reducing conditions or in response to administration of an exogenous reducing agent.
    Type: Grant
    Filed: November 14, 2003
    Date of Patent: December 4, 2007
    Assignees: Alza Corporation, Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Samuel Zalipsky, Alberto Gabizon
  • Patent number: 6984396
    Abstract: Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The linkage is stable under nonreducing conditions. The conjugate can be incorporated into liposomes for administration in vivo and release of the therapeutic agent in response to endogeneous in vivo reducing conditions or in response to administration of an exogeneous reducing agent.
    Type: Grant
    Filed: January 25, 2002
    Date of Patent: January 10, 2006
    Assignee: Alza Corporation
    Inventors: Samuel Zalipsky, Alberto A. Gabizon
  • Patent number: 6797835
    Abstract: A phospholipidic composition with an L-&agr;-glycerophosphatidyl-choline concentration of at least 10% by weight is described, where said composition is granular and also contains, in addition to L-&agr;-glycerophosphatidylcholine, at least one granulation aid selected from the group consisting of a monophosphate, diphosphate or triphosphate of an alkali metal or an alkaline earth metal or a mixture thereof.
    Type: Grant
    Filed: July 7, 2003
    Date of Patent: September 28, 2004
    Assignee: American Lecithin Company
    Inventors: Peter Fussbroich, Johannes Gareiss
  • Publication number: 20040006242
    Abstract: The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.
    Type: Application
    Filed: May 28, 2002
    Publication date: January 8, 2004
    Inventors: Lynn D. Hawkins, Sally T. Ishizaka
  • Patent number: 6602861
    Abstract: This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the formula: or pharmaceutically acceptable salts thereof wherein one of R1 and R2 is hydrogen and the other is hydrogen, a hydrocarbyl fatty acid acyl group having 4-26 carbon atoms or a hydrocarbyl heteroatom fatty acid acyl group having 3-25 carbon atoms, or and R is a naturally occurring polar head group characteristic of a glycerophospholipid isolated from endogenous sources; R3 is hydrogen or lower alkyl and R4 is hydrogen, hydrocarbyl containing from 1-18 carbon atoms in a principal chain and up to a total of 23 carbon atoms, said principal chain may contain 1-5 double bonds or 1-2 triple bonds; phenyl which may be unsubstituted or substituted with lower alkyl; naphthyl which may be unsubstituted or substituted with low
    Type: Grant
    Filed: April 16, 1992
    Date of Patent: August 5, 2003
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Charles Pidgeon, Robert J. Markovich
  • Patent number: 6600059
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Grant
    Filed: January 10, 2002
    Date of Patent: July 29, 2003
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Publication number: 20030027800
    Abstract: The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
    Type: Application
    Filed: March 19, 2001
    Publication date: February 6, 2003
    Inventors: Duane D. Miller, Gabor Tigyi, James T. Dalton, Vineet M. Sardar, Don B. Elrod, Huiping Xu, Daniel L. Baker, Dean Wang, Karoly Liliom, David J. Fischer, Tamas Virag, Nora Nusser
  • Publication number: 20030004338
    Abstract: The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
    Type: Application
    Filed: September 5, 2001
    Publication date: January 2, 2003
    Inventors: Wen Sen Li, John E. Thornton, Zhenrong Guo, Shankar Swaminathan
  • Patent number: 6469148
    Abstract: Synthetic methods for convenient large scale preparation of D-erythro sphingosines and ceramides of high isomeric purity are described.
    Type: Grant
    Filed: May 10, 2000
    Date of Patent: October 22, 2002
    Assignee: Lipiderm Ltd.
    Inventor: Elimelech Rochlin
  • Patent number: 6448422
    Abstract: This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.
    Type: Grant
    Filed: July 3, 2000
    Date of Patent: September 10, 2002
    Assignee: Eli Lilly and Company
    Inventors: Patrick Irving Eacho, Patricia Sue Foxworthy-Mason, Richard Waltz Harper, Ho-Shen Lin, Jose Eduardo Lopez, Michael Enrico Richett
  • Patent number: 6423855
    Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.
    Type: Grant
    Filed: January 12, 2000
    Date of Patent: July 23, 2002
    Assignee: Virginia Commonwealth University
    Inventors: Richard C. Franson, Raphael M. Ottenbrite
  • Patent number: 6413543
    Abstract: In order to form liposomes with a longer half-life in blood, use is made of defined with the general formula (A)
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: July 2, 2002
    Assignee: Max-Planck-Gesselschaft zur Forderung der Wissenschaften E.V.
    Inventor: Hans-Jörg Eibl
  • Patent number: 6407137
    Abstract: The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the blood brain barrier. Once in the central nervous system, the prodrug is hydrolyzed into the fatty acid carrier and the drug to release the drug. In a preferred embodiment, the carrier is 4, 7, 10, 13, 16, 19 docosahexa-enoic acid and the drug is dopamine. Both are normal components of the central nervous system. The covalent bond between the drug and the carrier preferably is an amide bond, which bond may survive the conditions in the stomach. Thus, the prodrug may be ingested and will not be hydrolyzed completely into the carrier molecule and drug molecule in the stomach.
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: June 18, 2002
    Assignee: Protarga, Inc.
    Inventor: Victor E. Shashoua
  • Patent number: 6380177
    Abstract: Applicant has probed the Edg2 lysophosphatidic acid (LPA) receptor with a series of LPA analogs to determine receptor activation. The present invention is drawn to a series of LPA analogs which function as Edg2 receptor agonists, and methods of using such compounds to activate the Edg2 receptor of the surface of a cell. The compounds of the invention comprise a glycerol backbone with an Sn1 ester-linked saturated or unsaturated alkyl group, substitutions of the hydroxyl group (—OH) at carbon two of the glycerol backbone, and optional replacement of the phosphate di-anion with either a hydroxyl group or a dimethylated phosphate. These LPA analogs may find uses in cancer and neurological disorders.
    Type: Grant
    Filed: June 23, 2000
    Date of Patent: April 30, 2002
    Assignee: Atairgin Technologies, Inc.
    Inventor: James R. Erickson
  • Publication number: 20010056074
    Abstract: The invention consists of a compound of the general formula (I) below: 1
    Type: Application
    Filed: January 4, 2001
    Publication date: December 27, 2001
    Inventors: Jean-Jacques Yaouanc, Erwann Guenin, Jean-Claude Clement, Anne-Cecile Herve, Claude Ferec, Virginie Floch, Herve des Abbayes