Phosphorus Containing Patents (Class 554/78)
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Publication number: 20100233349Abstract: Biomass extracts with high protein and nutritional value and methods for making the same are disclosed. Such extracts may include cakes with low residual oil and high levels of desirable constituents and oils that require little to no downstream processing upon extraction from the biomass. Also includes methods of extracting desirable products from an oil bearing biomass.Type: ApplicationFiled: February 15, 2010Publication date: September 16, 2010Applicant: Crown Iron Works CompanyInventors: Lon E. Smallridge, Floyd C. Teeter, JR.
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Patent number: 7771711Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.Type: GrantFiled: June 17, 2004Date of Patent: August 10, 2010Assignees: Yissum Research Development Company of The Hebrew University of Jerusalem, Biolab Ltd.Inventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
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Publication number: 20100172967Abstract: Objects of the present invention are to provide a compound which is useful as a surface modifier for producing a drug carrier or the like, or a salt thereof; a fine particle comprising the same; and the like.Type: ApplicationFiled: February 19, 2010Publication date: July 8, 2010Applicants: KYOWA HAKKO KIRIN CO., LTD., TECHNO NETWORK SHIKOKU CO., LTD.Inventors: Hisao Nemoto, Masahiro Yamauchi, Hiroko Kusano, Yasuki Kato, Motoo Yamasaki, Toshiyuki Suzawa
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Publication number: 20100160224Abstract: A shelf-stable consumable composition may comprise one or more Probiotic-Mimicking Elements (PMEs) wherein the median particle size of the one or more PMEs is less than the median particle size of a probiotic from which the one or more PMEs were derived. In some embodiments, the median particle size of the one or more PMEs may be less than about 0.2 microns. In some embodiments, the PMEs may comprise at least one of peptides, fatty acids, bacteriocins, cell surface proteins, phospholipids, teichoic acids, and nucleic acids, and may be combined with one or more prebiotics, such as oligosaccharides, inulin, short-chain fructo-oligosaccharides, xylooligosaccharides, galactooligosaccharides, soyoligosaccharides, and lactulose/lactitol. Methods for preparing and using a shelf-stable consumable composition for promoting digestive health in a subject are also described.Type: ApplicationFiled: October 14, 2009Publication date: June 24, 2010Inventors: David Thomas, James Steele
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Publication number: 20100145085Abstract: Methods are disclosed for extracting and separating polar lipids, including phospholipids, from materials containing oil, polar lipid, protein, ash, and/or carbohydrate, such as egg yolks and other phospholipid-containing materials. In particular, methods for extracting phospholipids from phospholipid-containing materials through the use of an aliphatic alcohol and control of temperature are disclosed. Using these methods, phospholipids in the aqueous liquid fraction will be efficiently separated and will precipitate readily, and can be subjected to separation for improved purity.Type: ApplicationFiled: July 28, 2009Publication date: June 10, 2010Applicant: Martek Biosciences CorporationInventor: Jesus Ruben Abril
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Patent number: 7700792Abstract: To provide a highly active LPA and a method of screening therewith. There is provided a method of screening a preventive and/or therapeutic substance for diseases in which LPA takes part, characterized in that a compound represented by any of formula (I), (II) and (III): [wherein the meaning of characters are described in the description] is used. The compounds obtained by the screening method or the screening kit of the present invention, their salts, their solvates and prodrugs thereof would modulate the binding of highly active LPA with LPA receptor in human and other mammals, so that they can be used as a preventive and/or therapeutic agent for diseases in which LPA takes part, for example, urinary diseases, central nervous diseases, inflammatory diseases, circulatory diseases, cancer, diabetes, immune system disorders and alimentary diseases.Type: GrantFiled: December 22, 2004Date of Patent: April 20, 2010Assignee: Ono Pharmaceutical Co., Ltd.Inventors: Akio Hayashi, Shinji Nakade, Hidehiro Suzuki
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Publication number: 20100086583Abstract: The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.Type: ApplicationFiled: September 2, 2009Publication date: April 8, 2010Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventor: Hansjörg EIBL
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Publication number: 20100029523Abstract: A lubricant from plant and/or animal oils and fats; a method for producing a lubricating oil, and the oil produced thereby. The lubricant comprises a diester produced by epoxidising an animal or plant fat or oil having an iodine number above about 7 and reacting the epoxidised oil or fat with a carboxylic acid anhydride in the presence of a basic catalyst.Type: ApplicationFiled: August 10, 2005Publication date: February 4, 2010Inventors: Herman Benecke, Bhima R. Vijayendran, Jeffrey Cafmeyer
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Publication number: 20100018922Abstract: A method for processing vegetable oil miscella is provided. The method includes steps of feeding vegetable oil miscella to a conditioned polymeric microfiltration membrane, and recovering a permeate stream having a decreased weight percent of phospholipids compared with the weight percent of phospholipids provided in the miscella. The retentate stream can be further processed for the recovery of lecithin. The polymeric microfiltration membrane can be conditioned for the selective separation of phospholipids in the miscella. A method for conditioning a membrane for selective separation of phospholipids from vegetable oil miscella, and the resulting membrane, are provided. The membrane which can be conditioned can be characterized as having an average pore size of between about 0.1? and about 2?.Type: ApplicationFiled: January 13, 2009Publication date: January 28, 2010Applicant: Cargill, IncorporatedInventors: Bassam Jirjis, Harapanahalli S. Muralidhara, Dennis D. Otten
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Publication number: 20100008863Abstract: New targeting or therapeutic compounds which can be incorporated into a composition of gas-filled microvesicles. The invention further relates to gas-filled microvesicles for diagnostic and/or therapeutic use comprising said compounds and to their method of use. The new compounds are compounds of formula M-S-T, wherein: M represents a component capable of associating with an envelope of a gas-filled microvesicle; T represents a component comprising a targeting ligand or a therapeutic agent; and S represents a component comprising at least two bissulfone groups.Type: ApplicationFiled: December 19, 2007Publication date: January 14, 2010Inventors: Rolf E. Swenson, Philippe Bussat, Bernard Lamy, Sibylle Pochon, Kondareddiar Ramalingam
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Publication number: 20090326070Abstract: Activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids are provided herein.Type: ApplicationFiled: April 30, 2009Publication date: December 31, 2009Applicant: COMPLEXA INC.Inventors: Bruce A. FREEMAN, Bruce BRANCHAUD
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Publication number: 20090292019Abstract: There are provided various polyunsaturated fatty acid monoglycerides and derivatives thereof. These compounds can be useful as cancer chemopreventive agents, cancer treating agent, inhibiting tumor growth or cell proliferation, reducing tumor growth or as radioenhencers for radiotherapy of cancer.Type: ApplicationFiled: August 3, 2009Publication date: November 26, 2009Inventor: Samuel FORTIN
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Patent number: 7595411Abstract: The present invention relates to compositions comprising a water-insoluble pharmaceutically active ingredient or a substance having low water solubility, and a compound represented by Structural Formula (I): in which A is: The present invention further relates to methods of solubilizing substances of low water solubility, and methods of preparing compositions suitable for intravenous administration.Type: GrantFiled: October 21, 2004Date of Patent: September 29, 2009Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventor: Hans-Jörg Eibl
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Patent number: 7592469Abstract: The present invention relates to novel phosphoric triesters which comprise apolar lipid structures.Type: GrantFiled: October 1, 2003Date of Patent: September 22, 2009Assignee: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.Inventor: Hansjoerg Eibl
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Publication number: 20090215067Abstract: Cationic lipid compositions are provided that are useful for efficient delivery of macromolecules, such as nucleic acids, into a wide variety of eukaryotic cell types. Methods for using the compositions also are provided.Type: ApplicationFiled: April 27, 2009Publication date: August 27, 2009Applicant: MOLECULAR TRANSFER, INC.Inventors: Gulilat Gebeyehu, Taysir M. Jaouni, Joel Jessee
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Publication number: 20090209775Abstract: Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders, as well as inflammatory disorders, immune mediated diseases, autoimmune diseases and proliferative disorders, are provided. In addition, methods of synthesizing etherified and esterified oxidized phospholipids and of using same for preventing and treating atherosclerosis and other related disorders are also provided.Type: ApplicationFiled: February 17, 2009Publication date: August 20, 2009Applicant: Vascular Biogenics Ltd.Inventors: Dror Harats, Jacob George, Gideon Halperin, Niva Yacov, Eti Kovalevski-Ishai
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Publication number: 20090197839Abstract: Procedure for the obtaining a concentrate of the total fixed lipids of the kernels of the family Sapotaceae, genus Calocarpum, Chrysophyllum and Lucuma. The kernels (seeds removed of the endocarp), are squeezed by means of mechanical techniques that use pressure and heat, without using extractive liquids, getting a concentrate of lipidic juices (virgin) in a dry way and with their characteristic aroma. This concentrate of total fixed lipids can be fractioned in its main constituents by means of a process that consist of the emulsification of the lipids, followed by centrifugation or sedimentation, giving place to the stratification of the main constituents and their consequent separations. The main constituent consist of oils, of phospholipids and of residues glucosidic triterpenes plus of sterols fractions.Type: ApplicationFiled: July 21, 2004Publication date: August 6, 2009Inventor: Luis De La Llata Romero
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Patent number: 7553981Abstract: The subject of the present invention is new substances which are derived from naturally occurring ceramides and sphingosine and also from synthetic compounds with principally the same structure in that they represent dimers, trimers, tetramers etc., hence i.e. oligomers of the initial substances.Type: GrantFiled: June 4, 2004Date of Patent: June 30, 2009Assignee: PLT Patent and License Trading Ltd.Inventors: Hans Uwe Wolf, Jörg Martin Dormann
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Patent number: 7550449Abstract: It is an object of the present invention to synthesize a carba cyclic phosphatidic acid derivative having a novel structure by substituting O at position sn-2 of the glycerol skeleton with CH2, and study the action of the obtained derivative to suppress cancer cell invasion. The present invention provides a compound represented by the following formula (I): wherein R represents a linear or branched alkyl group containing 1 to 30 carbon atoms, a linear or branched alkenyl group containing 2 to 30 carbon atoms, or a linear or branched alkynyl group containing 2 to 30 carbon atoms, wherein these groups may comprise a cycloalkane ring or aromatic ring; and M represents a hydrogen atom or counter cation.Type: GrantFiled: June 10, 2003Date of Patent: June 23, 2009Inventors: Kimiko Murofushi, Mutsuko Mukai, Susumu Kobayashi, Hiromu Murofushi
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Patent number: 7524981Abstract: A phospholipid derivative represented by the following formula (1): wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R1CO and R2CO independently represent an acyl group having 8 to 22 carbon atoms, symbol “a” independently represents an integer of 0 to 5, symbol “b” independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1?k1?(k+2)/2, 0?k2, and k1+k2+k3=k+2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.Type: GrantFiled: December 12, 2003Date of Patent: April 28, 2009Assignees: NOF Corporation, DAIICHI Pharmaceutical Co., Ltd.Inventors: Kazuhiro Kubo, Chika Itoh, Syunsuke Ohhashi, Tohru Yasukohchi, Yusuke Ohkawa, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
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Publication number: 20090068697Abstract: Fluorogenic lysophosphatidic acid derivatives which can be used as substrates in a continuous, fluorogenic assay that can be performed in microtiter plates. The assays permit measuring LysoPLD activity levels in normal events such as pregnancy or disease states such as cancer. In addition, the present invention can be adopted to high throughout screening (HTS) for identification of potential inhibitors of lysoPLD activity.Type: ApplicationFiled: October 28, 2008Publication date: March 12, 2009Applicant: Echelon Biosciences IncorporatedInventors: Colin Ferguson, Glenn Prestwich
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Patent number: 7495116Abstract: A phospholipid derivative represented by the formula (1) (Z represents a residue of a compound having 3 to 10 hydroxyl groups; AO represents an oxyalkylene group having 2 to 4 carbon atoms; R1CO and R2CO represent an acyl group having 8 to 22 carbon atoms; X represents hydrogen atom, an alkali metal atom, ammonium or an organic ammonium; “a” represents an integer of 0 to 4; “b” represents 0 or 1; Q represents hydrogen atom or methyl group; m represents an average number of moles of the oxyalkylene group added; and m, k1, k2, and k3 are numbers satisfying the following conditions: 3?m?200, 9?m×(k1+k2+k3)?1000, 1?k1?2, 0?k2?9 and 0?k3?9, and 3?k1+k2+k3?10), which is highly safe for living bodies, and is suitably used for solubilization and dispersion of physiologically active substances and the like, or in the fields of drug delivery systems such as liposomes and cosmetics.Type: GrantFiled: March 28, 2003Date of Patent: February 24, 2009Assignees: NOF Corporation, Daiichi Pharmaceutical Co., Ltd.Inventors: Chika Itoh, Kazuhiro Kubo, Syunsuke Ohhashi, Tohru Yasukohchi, Hiroshi Kikuchi, Norio Suzuki, Miho Takahashi, Hitoshi Yamauchi
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Patent number: 7465817Abstract: The present invention relates to a phospholipid dreivative having a substituted or unsubstituted polyhydroxylated aliphatic carbocycle attached to the sn-1 or sn-2 position of the glycerol backbone, a pharmaceutical composition comprising said phospholipid, a method for preparing said phospholipid and a medicament comprising said phospholipid.Type: GrantFiled: November 20, 2003Date of Patent: December 16, 2008Assignee: Charite-Universitats Medizin BerlinInventors: Kerstin Danker, Michael Mickeleit, Dieter Mueller, Werner Reutter
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Publication number: 20080213324Abstract: Described herein are synthetically modified fullerene molecules, wherein the fullerene is preferably ellipsoid in shape with an equatorial band and two opposing poles, comprising an adduct at one or both poles, at least one adduct being a hydrophobic chemical moiety capable of anchoring the fullerene on or in a lipid membrane.Type: ApplicationFiled: March 3, 2008Publication date: September 4, 2008Applicant: Luna Innovations IncorporatedInventors: Zhiguo Zhou, Robert P. Lenk, Darren Macfarland, Kenneth L. Walker, Jing Zhang, Stephen R. Wilson
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Publication number: 20080214849Abstract: The invention relates to phospholipid-like compounds having defined apolar constituents and to the use of such compounds as liposomes, active ingredients, and solubilizers.Type: ApplicationFiled: August 29, 2007Publication date: September 4, 2008Applicant: Max-Planck-Gesellschaft Zur Foerderung Der Wissenshaften E.V.Inventors: Eibl Hansjorg, Thomas Hottkowitz
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Patent number: 7420071Abstract: There are provided novel thermally stable surfactants for use with fillers in the preparation of polymer composites and nanocomposites. Typically, surfactants of the invention are urethanes, ureas or esters of thiocarbamic acid having a hydrocarbyl group of from 10 to 50 carbons and optionally including an ionizable or charged group (e.g., carboxyl group or quaternary amine). Thus, there are provided surfactants having Formula I: wherein the variables are as defined herein. Further provided are methods of making thermally stable surfactants and compositions, including composites and nanocomposites, using fillers coated with the surfactants.Type: GrantFiled: May 4, 2005Date of Patent: September 2, 2008Assignee: UChicago Argonne, LLCInventor: David J. Chaiko
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Publication number: 20080145413Abstract: This disclosure describes structural elements that enhance fusogenicity of lipids and lipid assemblies (e.g. liposomes) with biological membranes, in particular cell membranes, and use of such structures. The elements are pH sensitive in terms of charge and hydrophilicity and undergo a polar—apolar transition when exposed to low pH.Type: ApplicationFiled: December 19, 2006Publication date: June 19, 2008Inventors: Steffen Panzner, Christian Reinsch, Evgenios Siepi
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Publication number: 20080145902Abstract: A method for the preparation of highly polyunsaturated fatty acid-containing phosphatidylserine and phosphatidic acid by phospholipase D-catalyzed transphosphatidylation of fish liver phosphatidylcholine and L-serine is disclosed.Type: ApplicationFiled: February 15, 2008Publication date: June 19, 2008Inventors: Su Chen, Hung Kwong
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Publication number: 20080132712Abstract: Disclosed is a method for the reduction of residual peroxides in vegetable oils, preferably epoxidized vegetable oils using a phosphorous compound preferably alkyl/aryl substituted phosphite compounds or hypophosphorous acid and its derivatives.Type: ApplicationFiled: December 5, 2006Publication date: June 5, 2008Inventors: Michael G. Denoux, Ritchie Tregre, Garrett Mineo
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Publication number: 20080113942Abstract: The present invention is a phosphorylcholine-containing chemical compound represented by the following formula (1) or (2). (CH3)3N+CH2CH2PO4?CH2COOH ??(1) (CH3)3N+CH2CH2PO4?CH2COONa ??(2) The object of the present invention is to provide a new phosphorylcholine-containing compound that is useful as a surface treatment agent or a source material of a surface treatment agent. Another object is to provide a manufacturing method that has a high industrial utility value.Type: ApplicationFiled: November 28, 2005Publication date: May 15, 2008Inventors: Yukimitsu Suda, Kazuyuki Miyazawa
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Publication number: 20080112917Abstract: The present invention concerns novel sphingolipid-polyalkylamines conjugates, a process for their preparation and pharmaceutical compositions comprising the same. In particular, the present invention concerns ceramide based polyalkylamine conjugates and its use as a capturing agent. A preferred ceramide polyalkylamine conjugate is a ceramide-spermine conjugate, more preferably, N-palmitoyl D-erythro sphingosyl-1-carbamoyl spermine.Type: ApplicationFiled: June 17, 2004Publication date: May 15, 2008Applicants: BIOLAB LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEMInventors: Yechezkel Barenholz, Dmitri Simberg, Elimelech Rochlin
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Publication number: 20080103073Abstract: The present disclosure is directed to compounds and methods of making the compounds having the formula: where X is a functional group chosen from: and wherein R is chosen from hydrogen, n-alkyl, iso-alkyl, aryl, heterocyclic ring, and nitrogen or a sulfur containing group, and n ranges from 0 to 4.Type: ApplicationFiled: October 31, 2006Publication date: May 1, 2008Inventor: Atanu Adhvaryu
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Publication number: 20080103321Abstract: The present invention provides a continuous process for producing an oil based phosphate containing product. The continuous process includes mixing water with at least one base and an orthophosphoric acid to produce a liquid phosphate salt containing solution. This solution is then dried, granulated, and mixed with a base stock hydrocarbon to form the oil based phosphate containing product.Type: ApplicationFiled: October 26, 2007Publication date: May 1, 2008Applicant: EnviroFuels LLCInventors: Dustin K. James, C. Edward Baxter
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Patent number: 7351428Abstract: In order to form liposomes with a longer half-life in blood, use is made of defined formula (A)Type: GrantFiled: May 7, 2004Date of Patent: April 1, 2008Assignee: Max-Planck-Gesselschaft zur Forderung der Wissenschaften E.V.Inventor: Hans-Jörg Eibl
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Patent number: 7309721Abstract: The present invention encompasses compounds or Formula (I): as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.Type: GrantFiled: February 27, 2003Date of Patent: December 18, 2007Assignee: Merck + Co., Inc.Inventors: Richard J. Budhu, George A. Doherty, Jeffrey J. Hale, Christopher L. Lynch, Sander G. Mills, William E. Neway, III
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Patent number: 7303760Abstract: Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleavable dithiobenzyl linkage. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of mitomycin C in its original form. The linkage is stable under nonreducing conditions. The prodrug conjugate can be incorporated into liposomes for administration in vivo and release of mitomycin C in response to endogenous in vivo reducing conditions or in response to administration of an exogenous reducing agent.Type: GrantFiled: November 14, 2003Date of Patent: December 4, 2007Assignees: Alza Corporation, Yissum Research Development Company of the Hebrew University of JerusalemInventors: Samuel Zalipsky, Alberto Gabizon
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Patent number: 6984396Abstract: Conjugates of a hydrophobic moiety, such as a lipid, linked through a cleavable dithiobenzyl linkage to a therapeutic agent are described. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of the therapeutic agent in its original form. The linkage is stable under nonreducing conditions. The conjugate can be incorporated into liposomes for administration in vivo and release of the therapeutic agent in response to endogeneous in vivo reducing conditions or in response to administration of an exogeneous reducing agent.Type: GrantFiled: January 25, 2002Date of Patent: January 10, 2006Assignee: Alza CorporationInventors: Samuel Zalipsky, Alberto A. Gabizon
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Patent number: 6797835Abstract: A phospholipidic composition with an L-&agr;-glycerophosphatidyl-choline concentration of at least 10% by weight is described, where said composition is granular and also contains, in addition to L-&agr;-glycerophosphatidylcholine, at least one granulation aid selected from the group consisting of a monophosphate, diphosphate or triphosphate of an alkali metal or an alkaline earth metal or a mixture thereof.Type: GrantFiled: July 7, 2003Date of Patent: September 28, 2004Assignee: American Lecithin CompanyInventors: Peter Fussbroich, Johannes Gareiss
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Publication number: 20040006242Abstract: The present invention is directed to methods of treating diseases and disorders related to immune responses by administering one or more immunomodulatory compounds. In particular, the invention is directed to methods of stimulating and reducing immune responses, treating autoimmune conditions, treating allergic reactions and asthma, and preventing ischemic damage and asthma by administering one or more immunomodulatory compounds.Type: ApplicationFiled: May 28, 2002Publication date: January 8, 2004Inventors: Lynn D. Hawkins, Sally T. Ishizaka
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Patent number: 6602861Abstract: This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the formula: or pharmaceutically acceptable salts thereof wherein one of R1 and R2 is hydrogen and the other is hydrogen, a hydrocarbyl fatty acid acyl group having 4-26 carbon atoms or a hydrocarbyl heteroatom fatty acid acyl group having 3-25 carbon atoms, or and R is a naturally occurring polar head group characteristic of a glycerophospholipid isolated from endogenous sources; R3 is hydrogen or lower alkyl and R4 is hydrogen, hydrocarbyl containing from 1-18 carbon atoms in a principal chain and up to a total of 23 carbon atoms, said principal chain may contain 1-5 double bonds or 1-2 triple bonds; phenyl which may be unsubstituted or substituted with lower alkyl; naphthyl which may be unsubstituted or substituted with lowType: GrantFiled: April 16, 1992Date of Patent: August 5, 2003Assignee: Research Corporation Technologies, Inc.Inventors: Charles Pidgeon, Robert J. Markovich
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Patent number: 6600059Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.Type: GrantFiled: January 10, 2002Date of Patent: July 29, 2003Assignee: Virginia Commonwealth UniversityInventors: Richard C. Franson, Raphael M. Ottenbrite
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Publication number: 20030027800Abstract: The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.Type: ApplicationFiled: March 19, 2001Publication date: February 6, 2003Inventors: Duane D. Miller, Gabor Tigyi, James T. Dalton, Vineet M. Sardar, Don B. Elrod, Huiping Xu, Daniel L. Baker, Dean Wang, Karoly Liliom, David J. Fischer, Tamas Virag, Nora Nusser
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Publication number: 20030004338Abstract: The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.Type: ApplicationFiled: September 5, 2001Publication date: January 2, 2003Inventors: Wen Sen Li, John E. Thornton, Zhenrong Guo, Shankar Swaminathan
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Patent number: 6469148Abstract: Synthetic methods for convenient large scale preparation of D-erythro sphingosines and ceramides of high isomeric purity are described.Type: GrantFiled: May 10, 2000Date of Patent: October 22, 2002Assignee: Lipiderm Ltd.Inventor: Elimelech Rochlin
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Patent number: 6448422Abstract: This application relates to a novel compound of formula I, as defined herein, processes and intermediates for its preparation and the use of the compound of formula I as a substrate for a pharmaceutical screen.Type: GrantFiled: July 3, 2000Date of Patent: September 10, 2002Assignee: Eli Lilly and CompanyInventors: Patrick Irving Eacho, Patricia Sue Foxworthy-Mason, Richard Waltz Harper, Ho-Shen Lin, Jose Eduardo Lopez, Michael Enrico Richett
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Patent number: 6423855Abstract: The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.Type: GrantFiled: January 12, 2000Date of Patent: July 23, 2002Assignee: Virginia Commonwealth UniversityInventors: Richard C. Franson, Raphael M. Ottenbrite
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Patent number: 6413543Abstract: In order to form liposomes with a longer half-life in blood, use is made of defined with the general formula (A)Type: GrantFiled: November 20, 1998Date of Patent: July 2, 2002Assignee: Max-Planck-Gesselschaft zur Forderung der Wissenschaften E.V.Inventor: Hans-Jörg Eibl
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Patent number: 6407137Abstract: The invention involves the formation of a prodrug from a fatty acid carrier and a neuroactive drug. The prodrug is stable in the environment of both the stomach and the bloodstream and may be delivered by ingestion. The prodrug passes readily through the blood brain barrier. Once in the central nervous system, the prodrug is hydrolyzed into the fatty acid carrier and the drug to release the drug. In a preferred embodiment, the carrier is 4, 7, 10, 13, 16, 19 docosahexa-enoic acid and the drug is dopamine. Both are normal components of the central nervous system. The covalent bond between the drug and the carrier preferably is an amide bond, which bond may survive the conditions in the stomach. Thus, the prodrug may be ingested and will not be hydrolyzed completely into the carrier molecule and drug molecule in the stomach.Type: GrantFiled: July 9, 2001Date of Patent: June 18, 2002Assignee: Protarga, Inc.Inventor: Victor E. Shashoua
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Patent number: 6380177Abstract: Applicant has probed the Edg2 lysophosphatidic acid (LPA) receptor with a series of LPA analogs to determine receptor activation. The present invention is drawn to a series of LPA analogs which function as Edg2 receptor agonists, and methods of using such compounds to activate the Edg2 receptor of the surface of a cell. The compounds of the invention comprise a glycerol backbone with an Sn1 ester-linked saturated or unsaturated alkyl group, substitutions of the hydroxyl group (—OH) at carbon two of the glycerol backbone, and optional replacement of the phosphate di-anion with either a hydroxyl group or a dimethylated phosphate. These LPA analogs may find uses in cancer and neurological disorders.Type: GrantFiled: June 23, 2000Date of Patent: April 30, 2002Assignee: Atairgin Technologies, Inc.Inventor: James R. Erickson
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Publication number: 20010056074Abstract: The invention consists of a compound of the general formula (I) below: 1Type: ApplicationFiled: January 4, 2001Publication date: December 27, 2001Inventors: Jean-Jacques Yaouanc, Erwann Guenin, Jean-Claude Clement, Anne-Cecile Herve, Claude Ferec, Virginie Floch, Herve des Abbayes