The -c(=x)x- Is -c(=s)s- Patents (Class 558/235)
  • Patent number: 5274166
    Abstract: The present invention provides a dithiocarbamic acid salt which can be converted, at a very high yield, to an isothiocyanate suitable for use as an intermediate for production of thiazabicyclononane derivative or monothiourazole derivative; a process for producing said dithiocarbamic acid salt at a high yield without using thiophosgene having a toxicity problem; and a process for producing an isothiocyanate using said dithiocarbamic acid salt.The dithiocarbamic acid salt of the present invention is represented by general formula (2), and the process for producing said dithiocarbamic acid salt (2) comprises reacting an aniline represented by general formula (5) with carbon disulfide in the presence of 1,4-diazabicyclo[2.2.2]octane (3) or 4-pyrrolidinopyridine (4).The process for producing an isothiocyanate (1) according to the present invention comprises reacting the above dithiocarbamic acid salt (2) with a halogen compound.
    Type: Grant
    Filed: September 30, 1992
    Date of Patent: December 28, 1993
    Assignee: Ihara Chemical Industry Co., Ltd.
    Inventors: Mikio Yamaguchi, Hideo Ohi
  • Patent number: 5247087
    Abstract: Dithiocarbamic salts made from the reaction products of certain polyamines and epoxides have been found to be useful to clarify water, particularly the oil-in-water emulsions which accompany crude oil production. The water clarification may be accomplished by demulsification or flocculation. The polyamine reaction products themselves are novel and may have the structure ##STR1## where R" is selected from the group consisting of the structure --R--NH.sub.2 and ##STR2## where R is selected from the group consisting of straight, branched or cyclic alkylene moieties; arylene moieties; substituted straight, branched or cyclic alkylene moieties; substituted arylene moieties or mixtures thereof; and where R' is--(CH.sub.2).sub.m --O--R--O--(CH.sub.2).sub.m --where n and m independently range from 1 to 5 and q is 0 or 1. The dithiocarbamic salts made from these polyamines also find use as corrosion inhibitors.
    Type: Grant
    Filed: May 13, 1992
    Date of Patent: September 21, 1993
    Assignee: Baker Hughes Incorporated
    Inventor: Gordon T. Rivers
  • Patent number: 5159072
    Abstract: A method of heating dichloromethane laden streams to prevent discharge into the environment by contacting the laden stream with N,N-dialkyldithiocarbamate salt in the presence of oxygen and water.
    Type: Grant
    Filed: October 5, 1990
    Date of Patent: October 27, 1992
    Assignee: Eastman Kodak Company
    Inventor: Arunas V. Kavaliunas
  • Patent number: 5089619
    Abstract: Certain dithiocarbamates are used as reverse demulsifiers, corrosion and scale inhibitors, flocculants, biocides, flotation aids, water clarifiers, interface control agents and antifoaming agents.
    Type: Grant
    Filed: June 30, 1989
    Date of Patent: February 18, 1992
    Assignee: Petrolite Corporation
    Inventors: Neil E. S. Thompson, Robert G. Asperger
  • Patent number: 5073647
    Abstract: A method is provided for stabilizing alkylenebisdithiocarbamates (EBDC) by mixing the EBDC with chloralhydrate to reduce the content of alkylenethiourea (ETU) in the EBDC. The chloralhydrate is preferably added in an amount of about 0.1 to 5 weight percent based upon the EBDC. The preferably liquid (e.g., aqueous or alcoholic) reaction mixture is then preferably dried under vacuum. The stabilized EBDC product contains chloralhydrate, mono- and/or bis-trichloroethylol-alkylenethioureas, and less than about 0.015 weight percent ETU.
    Type: Grant
    Filed: April 24, 1990
    Date of Patent: December 17, 1991
    Assignee: Pennwalt France S.A.
    Inventors: Pieter C. Diepenhorst, Pieter Kool, Jacobus A. M. Nouws
  • Patent number: 5066674
    Abstract: Certain carbamate esters are used as inhibitors as cholesterol esterase and function as hypolipidemic and hypocaloric agents. The invention also relates to a method of decreasing the absorption of dietary cholesterol and fats through the wall of the intestinal tract.
    Type: Grant
    Filed: June 4, 1990
    Date of Patent: November 19, 1991
    Assignee: University of Iowa Research Foundation
    Inventor: Daniel M. Quinn
  • Patent number: 4894393
    Abstract: The subject of the invention is the choline diethyl-dithiocarbamate having the following structural formula: ##STR1## as well as a process for its preparation from choline chloride and sodium diethyl-dithio-carbamate trihydrate.This substance is useful in the treatment of degenerative brain diseases.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: January 16, 1990
    Assignee: Lafon Pharma S.A.
    Inventors: Dat-Xuong Nguyen, Jean Rapin, Thadee Staron
  • Patent number: 4883585
    Abstract: A process for the recovery of minerals from an ore or concentrate containing the same wherein the minerals are recovered in a froth from an aqueous pulp containing the ore or concentrate and wherein one or more mineral flotation agents are employed in the aqueous pulp to control the type of mineral in the froth is provided. The mineral flotation agent or agents employed in the process comprise sulfenyl dithiocarbamates characterized by the formula: ##STR1## wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen and hydrocarbyl groups with not more than one of R.sub.1 and R.sub.2 being hydrogen, n is 1 or 2, and R.sub.3 is a hydrocarbyl group.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: November 28, 1989
    Assignee: Phillips Petroleum Company
    Inventors: Clarence R. Bresson, Rector P. Louthan
  • Patent number: 4876375
    Abstract: Compounds having the formula: ##STR1## wherein: a. each of R, R.sup.2 and R.sup.4 when taken singly is a hydrogen atom, an alkyl group containing from 1 to about 15 carbon atoms, an aryl group containing from 6 to about 15 carbon atoms or a cycloalkyl group containing from 4 to about 10 carbon atoms;b. each of R.sup.1 and R.sup.3 when taken singly is a hydrogen atom, an alkyl group containing from 1 to about 15 carbon atoms; an aryl group containing from 6 to about 15 carbon atoms; a cycloalkyl group containing from 4 to about 10 carbon atoms or an alkenyl group containing from 2 to about 10 carbon atoms or R.sup.1 and R.sup.3 taken together form the group --CHYCY.dbd.CY-- in which Y is a hydrogen atom or a methyl group of R.sup.1 together with R.sup.2 form an alkylidene group containing from 1 to about 6 carbon atoms;c. R.sup.5 is a hydrogen atom or an alkyl group containing from 1 to about 15 carbon atoms;d. R.sup.
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: October 24, 1989
    Assignee: Ethyl Petroleum Additives, Inc.
    Inventor: William Y. Lam
  • Patent number: 4859787
    Abstract: A direct method of preparing dialkyl-dithiocarbamates of multivalent metals by reacting the oxide of a multivalent metal with a secondary amine and carbon disulfide while simultaneously heating to 50.degree.-95.degree. C. and removing the so-formed water of the reaction.Suitable metal oxides are preferably lead oxide, zinc oxide, copper(II)oxide, iron(III)oxide, nickel(III)oxide, antimony(III)oxide and manganese dioxide. The reaction is preferably conducted in a solvent for the metal-dialkyl-dithiocarbamate which forms an azeotrope with water in order to remove the water of the reaction with the solvent.
    Type: Grant
    Filed: April 22, 1988
    Date of Patent: August 22, 1989
    Assignee: C. F. Spiess & Sohn GmbH & Co.
    Inventors: Wolfram Spiess, Rolf Himmelreich
  • Patent number: 4853483
    Abstract: The present invention relates to a process for the preparation of alkyl semicarbazides by reaction of a dithiocarbamate and hydrazine in a weakly basic reaction media using a metal rearrangement catalyst.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: August 1, 1989
    Assignee: ICI Americas Inc.
    Inventor: Danielle A. Bright
  • Patent number: 4810811
    Abstract: The compounds of this invention are 1-phenylalkyl-2-mercaptotetrazole compounds which are dopamine-.beta.-hydroxylase inhibitors.
    Type: Grant
    Filed: August 24, 1987
    Date of Patent: March 7, 1989
    Assignee: SmithKline Beckman Corporation
    Inventors: Carl Kaiser, Lawrence I. Kruse
  • Patent number: 4761175
    Abstract: m-Anilido-urethanes of the formula ##STR1## where A and B independently of one another are oxygen or sulfur,R.sup.1 is alkyl, which is unsubstituted or substituted by halogen, alkoxy, alkoxycarbonyl or cyano, or is alkenyl which is unsubstituted or substituted by halogen, or is alkynyl which is unsubstituted or substituted by halogen or alkoxy, or is cycloalkyl which is unsubstituted or substituted by alkyl, or is aryl,R.sup.2 and R.sup.3 are each independently of one another hydrogen, alkyl, alkoxyalkyl or haloalkyl,R.sup.4 is alkylene of 1 to 6 carbon atoms which is unsubstituted or substituted by alkyl, alkoxyalkyl or haloalkyl,X is hydrogen, alkyl, haloalkyl, alkoxy, halogen, nitro or amino,Y is hydrogen, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl, halogen, alkoxy, haloalkoxy, alkylthio, nitro, aryl, thiocyanato, cyano, ##STR2## where R.sup.5 and R.sup.6 are each, independently of one another, hydrogen or have the meanings given for R.sup.
    Type: Grant
    Filed: July 5, 1983
    Date of Patent: August 2, 1988
    Assignee: BASF Aktiengesellschaft
    Inventors: Ulrich Schirmer, Rainer Becker, Bruno Wuerzer
  • Patent number: 4748186
    Abstract: S-trifluorobutenyl thiocarbonic acid esters of the formula ##STR1## and salts thereof, wherein X is R.sup.1 N or S and Y is RS or R.sup.3 R.sup.2 N;wherein R is a metal or a radical selected from alkyl, cycloalkylalkyl, halocycloalkylalkyl, alkenyl, haloalkyl, haloalkenyl, alkynyl, alkoxyalkyl, alkylthioalkyl, alkoxycarbonylalkyl, halophenoxyalkyl, trialkylsilylalkyl, (vinyl)dialkylsilylalkyl, (allyl)dialkylsilylalkyl, 2-chlorothiophene-5-ylmethyl, phenylalkyl, halophenylalkyl, nitrophenylalkyl, haloalkylphenylalkyl, dialkyl-2,3-dihydrobenzofuran-7-yl, [2-methyl-(1,1'-biphenyl)-3-yl]methyl, 3-phenoxybenzyl, phenylthioalkyl, halophenylthioalkyl, dialkylphosphoryl, dialkylthiophosphoryl, dialkylisoxazolylalkyl and thienylisoxazolylalkyl;wherein R.sup.1 is alkyl, cycloalkyl, cyano, dialkyl-2,3-dihydrobenzofuran-7-yl, halophenyl, halophenylalkyl, haloalkoxyphenyl, pyridinyl, halopyridinyl, alkyl-1,3,4-thiadiazolyl, haloalkyl-1,3,4-thiadiazolyl, benzothiazolyl, dialkyloxazolyl or thiazolinyl;wherein R.sup.
    Type: Grant
    Filed: June 30, 1986
    Date of Patent: May 31, 1988
    Assignee: FMC Corporation
    Inventors: Thomas G. Cullen, Anthony J. Martinez, Jacob J. Vukich
  • Patent number: 4736056
    Abstract: This invention relates to a process for preparing a malonic acid derivative compound of formula (i) depicted herein in high yield and high purity by reacting a malonic acid derivative compound of formula (ii) depicted herein with an alkylating agent of formula (iii) depicted herein in the presence of a solvent and a base.
    Type: Grant
    Filed: December 15, 1986
    Date of Patent: April 5, 1988
    Inventors: Oliver W. Smith, Russell J. Outcalt
  • Patent number: 4697033
    Abstract: Certain novel derivatives of carbamates and their use for the control of pests.
    Type: Grant
    Filed: December 24, 1985
    Date of Patent: September 29, 1987
    Assignee: Sandoz Ltd.
    Inventor: Clive A. Henrick
  • Patent number: 4683325
    Abstract: Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
    Type: Grant
    Filed: October 17, 1984
    Date of Patent: July 28, 1987
    Assignee: Merck Frosst Canada, Inc.
    Inventors: Richard Frenette, Joshua Rokach, Masatoshi Kakushima, Robert N. Young
  • Patent number: 4645661
    Abstract: A method for alleviating cisplatin compound-induced nephrotoxicity in animals comprising administering to the animal an effective amount of a polar dithiocarbamate compound. The polar dithiocarbamate compounds have the formula: ##STR1## In the above formula, R.sup.1 and R.sup.2 are hydrocarbon groups and R.sup.1, R.sup.2, or both R.sup.1 and R.sup.2 contain a polar group substituted thereon. M is a pharmaceutically acceptable cation and n is an integer of from 1 to 3.Novel polar dithiocarbamate compounds are disclosed as well.
    Type: Grant
    Filed: June 29, 1984
    Date of Patent: February 24, 1987
    Assignee: St. Jude Children's Research Hospital
    Inventor: Gregory R. Schonbaum
  • Patent number: 4613615
    Abstract: The invention relates to a plant protecting composition which contains 1 to 80% by weight substituted alkoxycarbonyl dithiocarbamates or thiolcarbamates of formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and stand for hydrogen, straight or branched chain, saturated or unsaturated alkyl, alkoxyalkyl, alkylaminoalkyl, dialkylaminoalkyl having 1 to 10 carbon atoms, cycloalkyl, phenyl or halogenphenyl,R.sup.3 stands for straight or branched chain, saturated or unsaturated alkyl, cycloalkyl, phenyl or halogenphenyl, andX stands for oxygen or sulfur,as well as 10 to 90% by weight solid and/or liquid diluent(s) and 1 to 30% by weight additive(s).The novel compounds of formua (I) may be obtained in such way that a salt of disubstituted dithiocarbamic acid or thiolcarbamic acid of formula (II) ##STR2## wherein R.sup.1, R.sup.
    Type: Grant
    Filed: May 21, 1984
    Date of Patent: September 23, 1986
    Assignee: Borsodi Vegyi Kombinat
    Inventors: Gyula Szilagyi, Csaba Tar, Mariann Bendly, Erzsebet Dienes nee, Mezo, Gabor Boda, Janos Csutak