Oxygen Attached Indirectly To The Cyano Group By Nonionic Bonding (e.g., Nitro Group, Etc.) Patents (Class 558/410)
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Patent number: 10494330Abstract: The purpose of the present invention is to provide a cooling agent composition containing a novel methyl menthol derivative having no undesirable feeling of stimulation, malodor, bitterness, or the like, it being possible to use the cooling agent composition as a cooling agent or sensory stimulation agent having exceptional persistence of a sense of coolness and refreshing feeling. The present invention pertains to a cooling agent composition containing a methyl menthol derivative represented by general formula (1A) or general formula (1B).Type: GrantFiled: March 24, 2016Date of Patent: December 3, 2019Assignee: TAKASAGO INTERNATIONAL CORPORATIONInventors: Hisanori Itoh, Yoji Hori, Masashi Otsuka, Takaji Matsumoto, Tomoharu Sato
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Patent number: 10478388Abstract: A skin engaging shaving aid member suitable for use in a shaving device, said skin engaging shaving aid member comprising a thermally resilient sensate such as N-substituted menthanecarboxamide.Type: GrantFiled: September 25, 2013Date of Patent: November 19, 2019Assignee: The Gillette Company LLCInventors: Xiandong Wang, Fatima Abdulhussain Jabalpurwala, Katharine Anne Bakes
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Publication number: 20150111910Abstract: Compounds of formula (I) are of use in the modulation of Kv3.1, Kv.3.2 and Kv3.3 channels and have utility in the treatment or prevention of related disorders.Type: ApplicationFiled: May 22, 2013Publication date: April 23, 2015Applicant: AUTIFONY THERAPEUTICS LIMITEDInventors: Agostino Marasco, Giuseppe Alvaro, Anne Dècor, Dieter Hamprecht, Paolo Dambruoso, Simona Tommasi
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Publication number: 20150094474Abstract: The present invention relates to derivatives of compounds which are known to be of use in the field of agriculture. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more changes one or more of which may be considered to represent a change of oxidation state relative to the groups in the original compound. We refer to these compounds generally as redox derivatives. The compounds are of use as insecticides, herbicides and insect repellents.Type: ApplicationFiled: March 13, 2013Publication date: April 2, 2015Inventors: William Thompson, Peter Jackson, Derek Lindsay, Thomas Screen, Benjamin Moulton, Christopher Urch
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Patent number: 8853393Abstract: The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.Type: GrantFiled: July 29, 2011Date of Patent: October 7, 2014Assignee: Anhui New Star Pharmaceutical Development Co., Ltd.Inventors: Ziao Xu, Yuanhai Zhao, Degang Li, Xiaoxiang Li
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Publication number: 20140296339Abstract: Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.Type: ApplicationFiled: June 17, 2014Publication date: October 2, 2014Inventors: Thomas G. Gant, Sepehr Sarshar
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Publication number: 20140249244Abstract: The present invention relates to polymer, homo- or copolymer or oligomer for the photoalignment of liquid crystals, especially for the planar orientation of liquid crystals, comprising a main chain and a side chain, wherein the side chain and/or main chain comprises a polar group, compositions thereof, and its use for optical and electro optical devices, especially liquid crystal devices (LCDs).Type: ApplicationFiled: September 28, 2012Publication date: September 4, 2014Applicant: ROLIC AGInventors: Sabrina Chappellet, Jean-Francois Eckert, Mohammed Ibn-Elhaj, Frederic Lincker, Satish Palika, Hubert Seiberle, Qian Tang, Eva Veenstra
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Publication number: 20140221384Abstract: The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified tetra-O-substituted NDGA compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as HIV infection, HPV infection, or HSV infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.Type: ApplicationFiled: April 7, 2014Publication date: August 7, 2014Applicant: ERIMOS PHARMACEUTICALS LLCInventors: Jonathan Daniel Heller, Qingqi Chen, Rocio Alejandra Lopez, Amanda Jean Morris
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Patent number: 8779123Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.Type: GrantFiled: December 3, 2013Date of Patent: July 15, 2014Assignee: Les Laboratoires ServierInventors: Maria Del Pilar Carranza, Maria Isabel Garcia Aranda, José Lorenzo Gonzalez, Frédéric Sanchez
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Patent number: 8779121Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.Type: GrantFiled: October 11, 2013Date of Patent: July 15, 2014Assignee: Les Laboratoires ServierInventors: Maria Del Pilar Carranza, Maria Isabel Garcia Aranda, José Lorenzo Gonzalez, Frédéric Sanchez
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Publication number: 20140163220Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.Type: ApplicationFiled: December 3, 2013Publication date: June 12, 2014Applicant: LES LABORATOIRES SERVIERInventors: Maria Del Pilar CARRANZA, Maria Isabel GARCIA ARANDA, José Lorenzo GONZALEZ, Frédéric SANCHEZ
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Publication number: 20140107334Abstract: Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.Type: ApplicationFiled: October 11, 2013Publication date: April 17, 2014Applicant: LES LABORATOIRES SERVIERInventors: Maria Del Pilar CARRANZA, Maria Isabel GARCIA ARANDA, José Lorenzo GONZALEZ, Frédéric SANCHEZ
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Publication number: 20140031576Abstract: A process for producing a mandelonitrile compound represented by the following formula (2), comprising a step of reacting a benzaldehyde compound represented by the following formula (1) with at least one member selected from the group consisting of metal cyanides and hydrogen cyanide in the presence of a phase transfer catalyst in a solvent.Type: ApplicationFiled: March 26, 2012Publication date: January 30, 2014Applicant: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Tatsuya Toriumi
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Publication number: 20130306917Abstract: The invention relates to a photovoltaic coating containing a mixture of organic N-type (acceptor) and P-type (donor) semiconductor compounds, which makes it possible, when selecting the donor/acceptor pair, to modulate the semiconductor properties of the photovoltaic coating so as to enable the use thereof within a photovoltaic device, wherein one of the organic semiconductors includes a quinone core.Type: ApplicationFiled: October 21, 2011Publication date: November 21, 2013Applicant: RHODIA OPERATIONSInventors: Floryan Decampo, Gerard Mignani, Bertrand Pavageau
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Publication number: 20130231478Abstract: The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.Type: ApplicationFiled: July 29, 2011Publication date: September 5, 2013Inventors: Ziao Xu, Yuanhai Zhao, Degang Li, Xiaoxiang Li
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Publication number: 20130158276Abstract: Provided is a catalyst for asymmetric reduction, which can be produced by a convenient and safe production method, has a strong catalytic activity, and has excellent stereoselectivity. The present invention relates to a ruthenium complex represented by the following formula (1): wherein R1 represents an alkyl group or the like; Y represents a hydrogen atom; X represents a halogen atom or the like; j and k each represent 0 or 1; R2 and R3 each represent an alkyl group or the like; R11 to R19 each represent a hydrogen atom, an alkyl group or the like; Z represents oxygen or sulfur; n1 represents 1 or 2; and n2 represents an integer from 1 to 3, a method for producing the ruthenium complex, a catalyst for asymmetric reduction formed from the ruthenium complex, and methods for selectively producing an optically active alcohol and an optically active amine using the catalyst for asymmetric reduction.Type: ApplicationFiled: June 17, 2011Publication date: June 20, 2013Applicant: TAKASAGO INTERNATIONAL CORPORATIONInventors: Taichiro Touge, Hideki Nara, Tomohiko Hakamada
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Patent number: 8278332Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold.Type: GrantFiled: October 27, 2011Date of Patent: October 2, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Patent number: 8263050Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxycrylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, hetType: GrantFiled: April 29, 2009Date of Patent: September 11, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Publication number: 20120190738Abstract: The present invention relates to compounds of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention also relates to the use of compound of general formula I for the treatment of malignancy by inhibition of PI3-Akt pathway and or induction of NO. The present invention further relates to a method of treating malignancy by inhibition of PI3-Akt pathway and or induction of NO by administration of compound or said composition to a mammal in need thereof.Type: ApplicationFiled: January 12, 2010Publication date: July 26, 2012Inventors: Santu Bandyopadhyay, Bikas Chandra Pal, Jaisankar Parasuraman, Siddhartha Roy, Jayashree Bagchi Chakrabotry, Indrani Choudhury Mukherjee, Sanjit Kumar Mahato, Aditya Konar, Srabanti Rakshit, Labanya Mandal, Dipyaman Ganguly, Kausik Paul, Anirban Manna, Jayaraman Vinayagam, Churala Pal
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Publication number: 20120172339Abstract: Novel resorcinol derivatives and methods of preparation and use are presented. These compounds can stimulate angiogenesis as a biological function triggered by the activation of one cannabinoid receptor distinct from CB1 and CB2. Thus, these compounds are specific ligands for one cannabinoid receptor distinct from CB1 and CB2. The invented compounds, when administered in a therapeutically effective amount to an individual or animal, results in a sufficiently high level of that compound in the individual or animal to cause a physiological response. The physiological response may be useful to treat a number of physiological conditions.Type: ApplicationFiled: July 9, 2010Publication date: July 5, 2012Applicant: Northeastern UniversityInventors: Alexandros Makriyannis, Spyridon P. Nikas, Shariku O. Alapafuja
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Patent number: 8168734Abstract: The invention relates to compounds represented by Formula (1): wherein Ra is independently halogen, cyano, —CF3, —CF2H, —CFH2, —OCF3, —OCF2H, —N?C?O, —N?C?S or alkyl having a carbon number of approximately 1 to approximately 20; in the alkyl, optional —CH2— may be substituted with —O—, —S—, —SO2—, —CO—, —COO—, —OCO—, —CH?CH—, —CF?CF— or —C?C—, and optional hydrogen may be substituted with halogen; Rb is fluorine or —CF3; A is independently 1,4-cyclohexylene, 1,4-cyclohexenylene, 1,4-phenylene, naphthalene-2,6-diyl, tetrahydronaphthalene-2,6-diyl, fluorene-2,7-diyl or bicyclo[2.2.Type: GrantFiled: February 23, 2011Date of Patent: May 1, 2012Assignees: JNC Corporation, Chisso Petrochemical CorporationInventor: Takashi Kato
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Patent number: 8133477Abstract: A composition comprising an inorganic particulate material in an amount of about 20 wt % to about 70 wt %, a carrier for the particulate material comprising a compound of formula (I) in an amount of about 1 wt % to about 70 wt %, a particulate material coating material in an amount of about 0 wt % to about 5 wt %, and a dispersing agent for the particulate material in an amount of about 0 wt % to about 5 wt %, based on the total weight of the composition, wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, and the non-alkoxy R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical.Type: GrantFiled: September 4, 2009Date of Patent: March 13, 2012Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Patent number: 8129560Abstract: A process for the preparation of a compound of formula (I), the process comprising: (i) the reaction of a compound of formula (III), with a compound of formula (IV) to give a compound of formula (II), and (ii) the reaction of the compound of formula (II) with a leaving group, to give the compound of formula (I).Type: GrantFiled: August 8, 2006Date of Patent: March 6, 2012Assignee: Syngenta Crop Protection, Inc.Inventors: Martin Charles Bowden, Thomas Aitcheson Clark, Fanny Giordano, Beat Jau, Hans-Dieter Schneider, Gottfried Seifert, Martin Zeller, Dominik Faber, Juerg Wiss
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Patent number: 8075808Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxycrylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, hetType: GrantFiled: April 29, 2009Date of Patent: December 13, 2011Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Patent number: 8070989Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from retinoid compounds—has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds having an alkoxy radical in the four (para) position (hereinafter “alkoxycrylenes”) on one of the phenyl rings having the formula (I): wherein one of R1 and R2 is a straight or branched chain C1-C30 alkoxy radical, preferably C1-C8, more preferably methoxy, and the non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C30 alkyl radical, preferably C2-C20. The alkoxycrylene compounds of formula (I) significantly increase the photostability of retinoid compounds in a composition by at least 3-fold and as much as 10-fold or greater. The ability of the alkoxycrylene compounds to stabilize the retinoid compound is concentration dependent, with the amount of retinoid photostabilization increasing with the concentration of the alkoxycrylene compound.Type: GrantFiled: July 31, 2009Date of Patent: December 6, 2011Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic, Jean Zhang
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Publication number: 20110282077Abstract: The object of the present invention is to solve the problems in the prior arts, and to find more improved reaction conditions for suppressing the racemization of the product and obtaining an optically active alcohol at a high optical purity. The inventors achieved to solve the above problems by using a solvent system that is capable of resolving both an asymmetric catalyst and a formate salt, allowing the hydrogen source and the asymmetric catalyst to be present in the same phase.Type: ApplicationFiled: May 10, 2011Publication date: November 17, 2011Applicant: Kanto Kagaku Kabushiki KaishaInventors: Taito Hatakeyama, Kunihiko Murata, Kunihiko Tsutsumi, Noriyuki Utsumi
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Patent number: 8039642Abstract: The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.Type: GrantFiled: October 12, 2007Date of Patent: October 18, 2011Assignee: Life Technologies CorporationInventors: Jixiang Liu, Richard Haugland, Wai-Yee Leung
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Patent number: 8008461Abstract: The present invention is to provide a process for efficiently producing an optically active alcohol including (R)-3-hydroxy-3-phenylpropanenitrile. One of the features of the present invention is a polypeptide having an activity of asymmetrically reducing 3-oxo-3-phenylpropanenitrile isolated from a microorganism belonging to the genus Candida to produce (R)-3-hydroxy-3-phenylpropanenitrile, DNA encoding the polypeptide and a transformant of producing the polypeptide. Another feature of the present invention is a process for producing an optically active alcohol such as (R)-3-hydroxy-3-phenylpropanenitrile by reducing a carbonyl compound such as 3-oxo-3-phenylpropanenitrile by use of the polypeptide or the transformant.Type: GrantFiled: October 20, 2005Date of Patent: August 30, 2011Assignee: Kaneka CorporationInventors: Noriyuki Kizaki, Makoto Ueda, Daisuke Moriyama, Naoaki Taoka, Yoshihiko Yasohara
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Patent number: 7981402Abstract: Polymers containing one or more novel photoactive moieties, sunscreen compositions including a mixture of a photoactive compound and a polymer containing one or more photoactive moieties are described herein. Polymer of formula (I): wherein the variables are as claimed. Also disclosed are methods for stabilizing a sunscreen composition, methods of filtering out ultra-violet light from a substrate by the addition of one or more of the foregoing polymers, methods accepting the triplet excited state energy with one or more of the foregoing polymer, and methods of increasing the UV-A Protective Value are described herein.Type: GrantFiled: August 11, 2010Date of Patent: July 19, 2011Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Publication number: 20110160228Abstract: The present invention relates to compounds of formula (I) below in which: —R1 and R3 represent, independently of one another, a methoxy group optionally substituted by one or more fluorine atoms, —R2 and R4 represent, independently of one another, a hydrogen atom or a methoxy group optionally substituted by one or more fluorine atoms, —A represents a ring chosen from the group comprising aryl and heteroaryl groups, said ring possibly being substituted by or fused to a heterocycle, —X represents a nitrogen atom or a CH group, and —Z1 represents a hydrogen atom or a halogen atom, preferably fluorine, and —Z2 represents a hydrogen atom, a halogen atom, preferably fluorine, a C1 to C4 alkyl group, an aryl group or a —CN, —SO2NR12R13, —SO2R9, —COOR15 or —COR15 group, and also to the pharmaceutically acceptable salts thereof, the isomers thereof and the prodrugs thereof.Type: ApplicationFiled: June 4, 2009Publication date: June 30, 2011Inventors: Mouâd Alami, Samir Messaoudi, Abdallah Hamze, Olivier Provot, Jean-Daniel Brion, Jian-Miao Liu, Jérôme Bignon, Joanna Bakala
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Patent number: 7968727Abstract: 4-bromomethyl-2?-formylbiphenyl and 4-bromomethyl-2?-hydroxymethylbiphenyl are useful starting material for the preparation various angiotenzin II antagonists, which are prepared from 4-bromomethyl-2?-cyanobiphenyl or 4?-bromomethylbiphenylcarboxyilic derivatives using selected hydride reagent.Type: GrantFiled: March 30, 2006Date of Patent: June 28, 2011Assignee: Lek Pharmaceuticals, D.D.Inventors: Anton Copar, Ljubomir Antoncic, Matej Antoncic
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Patent number: 7959834Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxycrylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, hetType: GrantFiled: July 20, 2010Date of Patent: June 14, 2011Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Publication number: 20110137049Abstract: The invention provides a chiral iridium aqua complex which has good preservation stability, can be easily produced, and enables asymmetric transfer hydrogenation in a higher yield and with higher stereoselectivity.Type: ApplicationFiled: July 6, 2009Publication date: June 9, 2011Applicants: SUMITOMO CHEMICAL COMPANY, LIMITEDInventor: Erick M. Carreira
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Patent number: 7919648Abstract: The invention relates to compounds represented by Formula (1): wherein Ra is alkyl or the like; Rb is fluorine or —CF3; A is 1,4-cyclohexylene, 1,4-phenylene or the like; Z is a single bond, alkylene or the like; Y is a single bond, alkylene or the like; and m and n are an integer of approximately 0 to approximately 5.Type: GrantFiled: December 7, 2006Date of Patent: April 5, 2011Assignees: Chisso Corporation, Chisso Petrochemical CorporationInventor: Takashi Kato
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Patent number: 7863475Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.Type: GrantFiled: August 24, 2007Date of Patent: January 4, 2011Assignee: Wellstat Therapeutics CorporationInventor: Shalini Sharma
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Patent number: 7816405Abstract: The present invention relates to calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy) -2-fluoropropoxy]phenyl]-2-isopropoxypropionate] represented by formula (I), a hydrate thereof, a crystal of the compound of formula (I), and a crystal of the hydrate of the compound of formula (I) which are useful as pharmaceuticals, and to processes for producing the same, and intermediates therefore, and processes for production thereof. There is need for (2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, in the form of a drug substance, purified so as to minimize a residual solvent content and having a uniformized specification and a highly favorable workability, and a process for producing the same. Crystalline calcium bis[(2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate], a calcium salt of (2S) -3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, solves the above problem.Type: GrantFiled: April 18, 2006Date of Patent: October 19, 2010Assignee: Eisai R&D Management Co., Ltd.Inventors: Masanobu Shinoda, Fumiyoshi Matsuura, Kaoru Murata, Masaharu Gotoda, Kenji Hayashi, Manabu Sasho, Naoki Ozeki, Susumu Inoue, Katsutoshi Nishiura, Yoshihiko Hisatake, Teiji Takigawa, Mamoru Miyazawa, Shigeto Negi, Keisuke Matsuyama
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Patent number: 7799317Abstract: Polymers containing one or more novel photoactive moieties, sunscreen compositions including a mixture of a photoactive compound and a polymer containing one or more photoactive moieties are described herein. Also disclosed are methods for stabilizing a sunscreen composition, methods of filtering out ultra-violet light from a substrate by the addition of one or more of the foregoing polymers, methods accepting the triplet excited state energy with one or more of the foregoing polymer, and methods of increasing the UV-A Protective Value are described herein.Type: GrantFiled: July 21, 2006Date of Patent: September 21, 2010Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Patent number: 7781470Abstract: The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.Type: GrantFiled: April 13, 2009Date of Patent: August 24, 2010Assignee: Bayer Schering Pharma AktiengesellschaftInventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Josef Pernerstorfer, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elizabeth Perzborn, Elke Stahl
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Publication number: 20100210719Abstract: Processes for preparing desvenlafaxine and stable amorphous O-desmethylvenlafaxine succinate solid dispersions with one or more pharmaceutically acceptable carriers.Type: ApplicationFiled: July 10, 2008Publication date: August 19, 2010Applicants: DR. REDDY'S LABORATORIES LTD., DR. REDDY'S LABORATORIES, INC.Inventors: Surya Narayana Devarakonda, Sesha Reddy Yarraguntla, Venu Nalivela, Ram Thaimattam, Subbareddy Peddireddy, Balaji Raghupati, Mohammed Azeezulla Baig, Srinivas Reddy Gade, Srinivas Reddy Mallepalli, Vijaywardhan Chitta, Satyanarayana Bollikonda, Saravanan Mohanarangam, Rajasekhar Kadaboina
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Publication number: 20100204486Abstract: The present invention is concerned with novel processes for the preparation of (+)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable salt thereof, and (?)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., pain, depression, anxiety disorders, eating disorders and urinary incontinence.Type: ApplicationFiled: April 27, 2007Publication date: August 12, 2010Applicant: MERCK & CO., INC.Inventors: Edward G. Corley, Jerry A. Murry, Bryon Simmons, Feng Xu
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Patent number: 7754191Abstract: A method of quenching fluorescence of a naphthalate polyester that is subjected to UV-radiation in an amount sufficient to cause the naphthalate polyester to reach an excited state and fluoresce, comprising adding to the naphthalate polyester a fluorescence quenching amount of a compound of formula (1): wherein R1 is an alkoxy; R2 is an organic linker; k is either zero or one; l is either zero or one, wherein the sum of k+l is one; and m is an integer in a range from zero to about twenty.Type: GrantFiled: November 3, 2008Date of Patent: July 13, 2010Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Patent number: 7713519Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxy crylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heType: GrantFiled: October 29, 2008Date of Patent: May 11, 2010Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Patent number: 7687524Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: GrantFiled: December 9, 2004Date of Patent: March 30, 2010Assignee: Merck Frosst Canada & Co.Inventors: Michael Boyd, Cheuk Lau, Christophe Mellon, Bruno Roy, John Scheigetz, Vouy Linh Truong
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Patent number: 7678792Abstract: The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit, PDGFR?, PDGFR?, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGF?, SRC, EGFR, trkB, FGFR3, FLT3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2?, BRK, KDR, c-raf or b-raf kinase, or mutant forms thereof.Type: GrantFiled: October 16, 2007Date of Patent: March 16, 2010Assignee: IRM LLCInventors: Donatella Chianelli, Christopher Cow, Yun He, Songchun Jiang, Xiaolin Li, Xiaodong Liu, Zuosheng Liu, Jon Loren, Valentina Molteni, Juliet Nabakka, Pingda Ren, Taebo Sim, Xiaodong Wang, Shuli You
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Patent number: 7662821Abstract: The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.Type: GrantFiled: October 12, 2004Date of Patent: February 16, 2010Assignee: Bayer Schering Pharma AGInventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
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Patent number: 7659309Abstract: The present invention relates to polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl)ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester, processes therein, pharmaceutical compositions thereof, and uses therewith.Type: GrantFiled: March 22, 2005Date of Patent: February 9, 2010Assignee: Vertex Pharmaceuticals IncorporatedInventors: Todd Blythe, Philip Nyce, Yong Cui
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Patent number: 7655701Abstract: Compounds of formula (I) and their use as fragrance ingredients wherein R is selected from methyl, ethyl, propyl, isopropyl, methoxy and ethoxy; R is hydrogen or methyl; and n is 0 or 1.Type: GrantFiled: June 15, 2006Date of Patent: February 2, 2010Assignee: Givaudan SAInventors: Felix Flachsmann, Jean-Pierre Bachmann
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Patent number: 7642367Abstract: The invention provides novel diamino-functionalized chalcone derivatives and analogues thereof. Use of the compounds, or compositions comprising them, as pharmaceutically active agents, in particular against bacterial and parasitic infections, is also disclosed. The invention further relates to a method for detecting inhibitory effects against e.g., bacteria, parasites, fungi, and helminths. The chalcones of the invention carry amino substituents and exhibit enhanced biological effects combined with improved metabolic and physicochemical properties, making the compounds useful as drug substances, in particular as antiparasitic and bacteriostatic agents.Type: GrantFiled: May 19, 2003Date of Patent: January 5, 2010Assignee: Lica Pharmaceuticals A/SInventors: Simon Feldbæk Nielsen, Kristian Schønning, Hasse Kromann, Thomas Boesen, Mogens Larsen
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Patent number: 7638515Abstract: The invention relates to tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents.Type: GrantFiled: October 12, 2004Date of Patent: December 29, 2009Assignee: Bayer Schering Pharma AktiengesellschaftInventors: Hartmut Rehwinkel, Stefan Baeurle, Markus Berger, Norbert Schmees, Heike Schaecke, Konrad Krolikiewicz, Anne Mengel, Duy Nguyen, Stefan Jaroch, Werner Skuballa
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Publication number: 20090291988Abstract: The instant invention relates to compounds of formula I, diagrammed below, wherein R3, E, D and Y are defined in the application, which are useful as reversible inhibitors of monoamine oxidase-B and/or monoamine oxidase-A, and therefore useful to treat or prevent neurological diseases or conditions in mammals, preferably humans.Type: ApplicationFiled: June 14, 2006Publication date: November 26, 2009Inventor: Renata Oballa