Oxygen Attached Indirectly To The Cyano Group By Nonionic Bonding (e.g., Nitro Group, Etc.) Patents (Class 558/410)
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Patent number: 7598416Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.Type: GrantFiled: June 23, 2008Date of Patent: October 6, 2009Assignee: Janssen Pharmaceutica N. V.Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
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Patent number: 7598292Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.Type: GrantFiled: September 16, 2004Date of Patent: October 6, 2009Assignee: Janssen Pharmaceutica, N.V.Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan R. DeAngelis
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Patent number: 7597825Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxy crylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heType: GrantFiled: August 9, 2007Date of Patent: October 6, 2009Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Patent number: 7588702Abstract: The photostabilizing electronic excited state energy—particularly singlet state energy from a UV-absorbing molecule has been found to be readily transferred to (accepted by) ?-cyanodiphenylacrylate compounds of formulas (I) and (V) having an alkoxy radical preferably in the four (para) position (hereinafter methoxycrylenes) on one or both of the phenyl rings: wherein at least one of R1 and R2 is a straight or branched chain C1-C12 alkoxy radical, preferably C1-C8, more preferably C1-C4, and most preferably methoxy, and any non-alkoxy radical R1 or R2 is hydrogen; and R3 is a straight or branched chain C1-C24 alkyl radical, preferably C12-C24, more preferably C20; ?wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl,Type: GrantFiled: January 30, 2008Date of Patent: September 15, 2009Assignee: Hallstar Innovations Corp.Inventors: Craig A. Bonda, Anna Pavlovic
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Patent number: 7560585Abstract: The present invention relates to an environmentally benign process for the preparation of (S)-?-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl)isovalerate from its diastereomeric mixture (RS)-?-cyano-3-phenoxybenzyl-(S)-2-(4-chlorophenyl) isovalerate.Type: GrantFiled: December 10, 2004Date of Patent: July 14, 2009Assignee: Council of Scientific & Industrial ResearchInventors: Vaddu Venkata Narayana Reddy, Khwaja Ishratullah, Penumatcha Venkata Krishnam Raju, Tella Ramesh Babu, Masna Mahesh, Chappeta Venkateswara Reddy
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Publication number: 20090118532Abstract: A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R1 and n are as hereinbefore defined; m and m? are independently 0 or 1; when m and m? are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when one of m and m? is 0 and the other is 1, A is an alType: ApplicationFiled: August 8, 2006Publication date: May 7, 2009Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Martin Charles Bowden, Thomas Aitcheson Clark, Fanny Giordano, Beat Jau, Hans-Dieter Schneider, Gottfried Seifert, Martin Zeller, Dominik Faber, Juerg Wiss
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Patent number: 7517896Abstract: The invention relates to compounds of formulae (II), (IV), and (VI) as shown below, wherein the several variable groups are as defined in the specification and claims. Processes for making these materials, and methods for using them in the synthesis of compounds for treatment of cardiovascular disorders and fibrotic disorders are also disclosed.Type: GrantFiled: August 8, 2005Date of Patent: April 14, 2009Assignee: Bayer AktiengesellschaftInventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Josef Pernerstorfer, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elizabeth Perzborn, Elke Stahl
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Patent number: 7507852Abstract: A process for the preparation of gamma-cyhalothrin comprising steps of a) chlorinating 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid to give 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride and b) esterifying 1R cis-Z 3-(2-chloro-3,3,3-trifluoro-1-propenyl)-2,2-dimethyl cyclopropanecarboxylic acid chloride with the (S)-cyanohydrin of 3-phenoxy benzaldehyde (III).Type: GrantFiled: February 23, 2004Date of Patent: March 24, 2009Assignee: Syngenta LimitedInventors: Stephen Martin Brown, Brian David Gott
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Patent number: 7476759Abstract: Compounds of Formula (I): wherein: R1 is optionally substituted —C4-12 alkyl, —C2-10alkylcycloalkyl, —C2-6alkylheterocycloalkyl, —C2-6alkylaryl, optionally substituted 5- or 6-membered aryl or heteroaryl with the proviso that R2 in not pyridinyl; Z is a bond, CH2, O, S, SO, SO2, NR4, OCR4R5 or CR4R5O; or Z, R1 and Q together form an optionally substituted fused tricyclic group; Q is an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X is COR3; R2 is CONH2, CO2H, CO2R7, SO2R7 or SO2NR8R9, with the proviso that R2 is not CO2R7, when X is CONH2; R3 is OR6 or NR8R9; R4 and R5 each independently is H, C1-6 alkyl or C1-4 alkylaryl; R6 is H or C1-6 alkyl; R7 is C1-6 alkyl; and R8 and R9 each independently is H or C1-6 alkyl; or R8 and R9 together with the nitrogen atom to which they are attached form a 5- or 6-membered ring which may optionally include 1 or more further heteroatoms selected from O, S and N; or physiologically functional derivatives thereof, with the proviso that formula (I) cType: GrantFiled: August 12, 2004Date of Patent: January 13, 2009Assignee: Glaxo Group LimitedInventors: Ian Holmes, Stephen Paul Watson
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Patent number: 7470723Abstract: The present invention relates to Diphenylethylene Compounds and compositions comprising a Diphenylethylene Compound. The present invention also relates to methods for preventing or treating various diseases and disorders by administering to a subject in need thereof one or more Diphenylethylene Compounds. In particular, the invention relates to methods for preventing or treating cancer or an inflammatory disorder by administering to a subject in need thereof one or more Diphenylethylene Compounds. The present invention further relates to articles of manufacture and kits comprising one or more Diphenylethylene Compounds.Type: GrantFiled: September 3, 2004Date of Patent: December 30, 2008Assignee: Celgene CorporationInventors: George W. Muller, Faribourz Payvandi, Ling H. Zhang, Michael J. Robarge, Roger Chen, Hon-Wah Man, Alexander L. Ruchelman
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Publication number: 20080300314Abstract: Compounds of the formula I give a cooling sensation to the mouth and skin: In Formula I, m is 0 or 1; X is —(CH2)n—R, where n is 0 or 1 and R is selected from —OR?. —COOH, —COOR?, —SO2NH2, —CHO, —COR??, and —CN, R? being selected from H and C1-C3 straight- and branched-chain alkyl. R? from C1-C4 straight- and branched-chain alkyl and R?? from C1-C3 straight- and branched-chain alkyl: Y is selected from H, —COOH and —OR??, where R?? has the significance previously referred to; and Z is H; with the provisos that (iii) When Y is H and X is any of the abovementioned significances, except —CN and —COOH, X is in the 4-position; (iv) when Y has a significance other than H, it is in the 5-position when X is in the 2-position and in the 6-position when X is in the 3-position. The compounds give a cooling sensation that can be more powerful than the best current commercial materials.Type: ApplicationFiled: June 30, 2008Publication date: December 4, 2008Applicant: Givaudan SAInventors: Christophe C. Galopin, Pablo Victor Krawec, Jay Patrick Slack, Lori W. Tigani, Stefan Michael Furrer
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Patent number: 7425649Abstract: The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR modulators to treat or inhibit the progression of, for example, dyslipidemia.Type: GrantFiled: September 14, 2005Date of Patent: September 16, 2008Assignee: Janssen Pharmaceutica N.V.Inventors: Gee-Hong Kuo, Rui Zhang, Aihua Wang, Alan DeAngelis, Keith Demarest, Patricia Pelton
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Publication number: 20080200554Abstract: Compounds of formula (I) and their use as fragrance ingredients wherein R is selected from methyl, ethyl, propyl, isopropyl, methoxy and ethoxy; R is hydrogen or methyl; and n is 0 or 1.Type: ApplicationFiled: June 15, 2006Publication date: August 21, 2008Applicant: Givaudan SAInventors: Felix Flachsmann, Jean-Pierre Bachmann
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Publication number: 20080146829Abstract: A process for the preparation of entacapone, in particular as the polymorphic form A, comprising the preparation of a compound of formula (V), as herein defined, by condensation of N,N-diethyl-cyano-acetamide with a compound of formula (IV), as herein defined, in the presence of a strong basic agent; the dealkylation of said compound of formula (V) to obtain entacapone and the crystallization thereof to the polymorphic form A.Type: ApplicationFiled: December 18, 2007Publication date: June 19, 2008Applicant: DIPHARMA FRANCIS s.r.l.Inventors: Simone MANTEGAZZA, Pietro ALLEGRINI, Gabriele RAZZETTI
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Patent number: 7368479Abstract: The invention relates to ?-sulfonylamino-acetonitrile derivatives of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein Ar1, and Ar2 independently of each other stand for an optionally substituted aryl or heteroaryl group, R1, and R2 stand independently of each other for hydrogen, optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R3 designates hydrogen, C3-C5alkenyl, C3-C5alkynyl or optionally substituted C1,-C5alkyl; R4 is optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R5 and R6 are independently of each other hydrogen or optionally substituted C1-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally substituted C3-C6cycloalkyl; R7, and R8 are independently of each other hydrogen or optionally substituted C1,-C5alkyl, optionally substituted C2-C5alkenyl, C2-C5alkynyl or optionally suType: GrantFiled: June 18, 2003Date of Patent: May 6, 2008Assignee: Syngenta Crop Protection, Inc.Inventors: Martin Eberle, Daniel Stierli, Urs Müller
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Publication number: 20070299276Abstract: A one-step process for the preparation of fluoroalkoxystyrene by contacting fluorinated olefin with a solution of hydroxystyrene is disclosed.Type: ApplicationFiled: June 22, 2006Publication date: December 27, 2007Inventor: Andrew Edward Feiring
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Patent number: 7304167Abstract: Biphenylcarboxamide compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.Type: GrantFiled: January 24, 2006Date of Patent: December 4, 2007Assignee: Janssen Pharmaceutica N.V.Inventors: Lieven Meerpoel, Leo Jacobs Jozef Backx
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Patent number: 7297816Abstract: Certain sulfonamide compounds are dual CCK1/CCK2 inhibitors useful in the treatment of CCK1/CCK2 mediated diseases.Type: GrantFiled: September 19, 2005Date of Patent: November 20, 2007Assignee: Janssen Pharmaceutica N.V.Inventors: Brett Allison, Victor K. Phuong, Marna C. W. Pippel, Michael H. Rabinowitz, Hariharan Venkatesan
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Patent number: 7279478Abstract: This invention relates to class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.Type: GrantFiled: September 3, 2003Date of Patent: October 9, 2007Assignee: Merck Frosst Canada & Co.Inventors: Michael Boyd, Marc Gagnon, Cheuk Lau, Christophe Mellon, John Scheigetz
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Patent number: 7232923Abstract: The invention provides methods for hydroaminating N-alkenoyl carbamates with aromatic amines.Type: GrantFiled: February 15, 2005Date of Patent: June 19, 2007Assignee: Imperial Innovations LimitedInventor: King Kuok (Mimi) Hii
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Patent number: 7223988Abstract: Embodiments of the present invention are directed toward a photoluminescent article comprising at least one host material and at least one color tunable photoluminescent dye. In certain embodiments, the emission spectrum of the at least one tunable photoluminescent dye may be dependent on the supramolecular architecture of the material. The photoluminescent emission spectrum of the dye is capable of being shifted by subjecting the article to an external stimuli such as, but not limited to, a mechanical deformation, a temperature change, aging of the article, a pressure change, exposure to a chemical compound. In specific embodiments, the color tunable photoluminescent dye is an oligo(phenylene vinylene) compound, such as, but not limited to, 1,4-Bis-(?-cyano-4-methoxystyryl)-benzene, 1,4-bis-(?-cyano-4-methoxystyryl)-2,5-dimethoxybenzene, and 1,4-bis-(?-cyano-4-(2-ethylhexyloxystyryl)-2,5-dimethoxybenzene and 2,5-bis-(?-cyano-4-methoxystyryl)-thiophene.Type: GrantFiled: June 20, 2003Date of Patent: May 29, 2007Assignee: Case Western Reserve UniversityInventors: Christiane Lowe, Christoph Weder
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Patent number: 7166746Abstract: The invention relates to N-bisaryl- and N-aryl-cycloalkylidenyl-a-hydroxy- and a-alkoxy acetic acid amides of the general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein R1 is hydrogen, C1–C12alkyl; C2–C12alkenyl; C2–C12alkynyl; C1–C12haloalkyl; R2 is hydrogen; optionally substituted alkyl; or optionally substituted alkynyl; R3 is optionally substituted aryl or optionally substituted heteroaryl; A is an optionally substituted saturated or unsaturated C3–C8-cycloalkylidene, optionally substituted phenylidene or optionally substituted saturated or unsaturated heterocyclylidene bridge, R4 and R5 are each independently hydrogen or an organic radical, and R6 is hydrogen; tri-C1–C4alkyl-silyl; di-C1–C4alkyl-phenylsilyl; C1–C4alkyl-diphenylsilyl; triphenylsilyl; optionally substituted alkyl; optionally substituted alkenyl or optionally substituted alkynyl.Type: GrantFiled: July 23, 2003Date of Patent: January 23, 2007Assignee: Syngenta Crop Protection, Inc.Inventors: Clemens Lamberth, Martin Zeller, Tibor Goegh
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Patent number: 7153813Abstract: The invention relates to novel substituted aryl ketones of the formula (I) in which Z, X, R and n are as defined in the disclosure, to processes for their preparation and to their use as crop treatment agents, and to intermediates for preparing compounds of the formula (I).Type: GrantFiled: February 12, 2003Date of Patent: December 26, 2006Assignee: Bayer AktiengesellschaftInventors: Hans-Georg Schwarz, Mark Wilhelm Drewes, Peter Dahmen, Dieter Feucht, Rolf Pontzen, Monika Schmitt
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Patent number: 6949669Abstract: Compounds of general formula (I) wherein the substituents are as defined in claim 1 are suitable for use as herbicidesType: GrantFiled: January 23, 2001Date of Patent: September 27, 2005Assignee: Syngenta Crop Protection, Inc.Inventors: Gerald Wayne Craig, Martin Eberle, Martin Zeller, Steven Scott Bondy, Daniel Dennis Comer, Soan Cheng, Julie Elizabeth Penzotti, Peter Grootenhuis, Jürg Ehrler
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Patent number: 6921822Abstract: The present invention relates to a process for preparing stereoisomerically enriched 4-aryl-4-hydroxybutanoic acid derivatives by reducing 4-aryl-4-ketobutanoic acid derivatives in the presence of ruthenium-containing catalysts.Type: GrantFiled: June 9, 2003Date of Patent: July 26, 2005Assignee: Bayer AktiengesellschaftInventors: Hans-Christian Militzer, Boris Bosch, Markus Eckert, Benjamin Meseguer
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Publication number: 20040236137Abstract: The invention relates to compounds of the general formula 1Type: ApplicationFiled: February 17, 2004Publication date: November 25, 2004Inventors: Thomas Goebel, Pierre Ducray
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Publication number: 20040229922Abstract: &agr;- and &bgr;-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.Type: ApplicationFiled: March 30, 2004Publication date: November 18, 2004Applicant: G.D. Searle & Co.Inventors: Michael J. Vazquez, Richard A. Mueller, John J. Talley, Daniel P. Getman, Gary A. DeCrescenzo, John N. Freskos, Robert M. Heintz, Deborah E. Bertenshaw
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Publication number: 20040229882Abstract: Compounds having the formula (I), 1Type: ApplicationFiled: October 29, 2003Publication date: November 18, 2004Inventors: Guixue Yu, John Macor, Timothy Herpin, R. Michael Lawrence, George C. Morton, Rejean Ruel, Graham S. Poindexter, Edward H. Ruediger, Carl Thibault
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Publication number: 20040224991Abstract: The present invention is related to the preparation and pharmaceutical use of novel benzamide derivatives as defined in the specification of formula (I) as histone deacetylase inhibitors (HDACI), their preparations and the methods of using these compounds or their pharmaceutically acceptable salt in the treatment of cell proliferative diseases, e.g. cancer and psoriasis.Type: ApplicationFiled: February 2, 2004Publication date: November 11, 2004Inventors: Xian-Ping Lu, Zhibin Li, Aihua Xie, Leming Shi, Boyu Li, Zhiqiang Ning, Song Shan, Tuo Deng, Weiming Hu
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Patent number: 6768019Abstract: The present invention relates to a novel 3,4-dihydro-1H-naphthalene derivative having a structure of formula 1 or formula 2, its pharmaceutically acceptable salts and their geometric isomers as a highly selective cyclooxygenase-2 inhibitor. Wherein R1, R2, X, A and Q are defined in this specification respectively.Type: GrantFiled: June 5, 2003Date of Patent: July 27, 2004Assignee: Cheil Jedang CorporationInventors: Ii Hwan Cho, Jee Woong Lim, Ji Young Noh, Jong Hoon Kim, Sang Wook Park, Hyung Chul Ryu, Je Hak Kim, Hyung Ok Chun, So Young Wang, Sung Hak Lee
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Publication number: 20040116518Abstract: The present invention relates to novel cinnamide compounds that are useful for treating inflammatory and immune diseases and cerebral vasospasm, to pharmaceutical compositions containing these compounds, and to methods of inhibiting inflammation or suppressing immune response in a mammal.Type: ApplicationFiled: December 1, 2003Publication date: June 17, 2004Applicant: Abbott LaboratoriesInventor: Indrani W. Gunawardana
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Publication number: 20040072878Abstract: A 2,3-diphenylpropionic acid derivatives or the salts represented by general formula (1) below; and pharmaceutical compositions and cell adhesion inhibitors comprising the derivatives or the salts as the active ingredient. In the formula, A, B and C independently represents a hydrogen atom or a monovalent substituent; and X and X′ independently represents a hydrogen atom or a monovalent substituent.Type: ApplicationFiled: August 19, 2003Publication date: April 15, 2004Inventors: Yoichiro Hoshina, Satoru Ikegami, Akihiko Okuyama, Tatsuhiro Harada, Atsushi Matsuo
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Publication number: 20040063755Abstract: The invention provides novel &bgr;2 adrenergic receptor agonist compounds of formula (I): 1Type: ApplicationFiled: August 18, 2003Publication date: April 1, 2004Inventors: Edmund J. Moran, John R. Jacobsen, Michael R. Leadbetter, Matthew B. Nodwell, Sean G. Trapp, James Aggen, Timothy J. Church
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Publication number: 20040063644Abstract: Novel urea and urethane derivatives of general formula (I) in which R1, R2, R3, R5, R5′, X, Y, B, m, n and o are as defined in Patent claim 1, and physiologically acceptable salts or solvates thereof are integrin inhibitors and can be employed for combating thromboses, cardiac infarction, coronary heart disease, arteriosclerosis, inflammation, tumours. Osteoporosis, infections and restenosis after angioplasty or in pathological processes maintained or propagated by antiogenesis.Type: ApplicationFiled: June 18, 2003Publication date: April 1, 2004Inventors: Wolfgang Stahle, Alfred Joncyk, Oliver Schadt, Simon Goodman
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Publication number: 20040063782Abstract: A new crystalline form of bicalutamide (form II) is disclosed. Bicalutamide form II is useful as a pharmaceutical and has antiandrogenic activity.Type: ApplicationFiled: September 12, 2003Publication date: April 1, 2004Inventor: Raymond J.H. Westheim
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Publication number: 20040059004Abstract: The invention provides for a non-steroidal compound having the formula 1Type: ApplicationFiled: July 24, 2003Publication date: March 25, 2004Inventors: Gerrit Herman Veeneman, Hubert JanJozef Loozen, Eduard Willem De Zwart, Jordi Mestres
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Publication number: 20040059149Abstract: Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R2 and/or R3) as shown in Formula 1: N(R4R5)C(R2R3)CO(OR1).Type: ApplicationFiled: June 26, 2003Publication date: March 25, 2004Inventor: Adnan M.M. Mjalli
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Publication number: 20040059147Abstract: The present invention relates to a new process for the synthesis of racemic and optically active bicalutamide starting from ethyl pyruvate and methyl methacrylate. The present invention discloses processes of preparing bicalutamide intermediates including ethyl-[2-{4-fluorophenyl sulfone}]-2-hydroxy propionate, 1,2-epoxy-2-methyl propionate and 2-hydrox-2-methyl-3-(4-fluorophenylthio) propionic acid. The present invention further discloses micronized rac-bicalutamide and the preparation thereof.Type: ApplicationFiled: September 22, 2003Publication date: March 25, 2004Inventors: Ben-Zion Dolitzky, Ofer Reany, Jenny Shammai
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Publication number: 20040044072Abstract: Disclosed are compounds of the formula 1Type: ApplicationFiled: December 6, 2002Publication date: March 4, 2004Inventors: Ruth TenBrink, Michel Maillard, Martha Warpehoski
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Publication number: 20040044241Abstract: A novel salt of O-desmethyl venlafaxine is provided, O-desmethylvenlafaxine succinate. Pharmaceutical compositions, dosage forms and methods of use are also provided.Type: ApplicationFiled: September 4, 2003Publication date: March 4, 2004Applicant: WyethInventors: Anthony F. Hadfield, Syed M. Shah, Michael W. Winkley, Karen W. Sutherland, James A. Provost, Aeri Park, Rex A. Shipplett, Brenton W. Russell, Beat T. Weber
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Publication number: 20040039034Abstract: The present invention relates to compounds of formula (I): 1Type: ApplicationFiled: April 30, 2003Publication date: February 26, 2004Inventors: John A. Tucker, Brian A. Sherer, Ying Zi Xu, Louis Brogley, Shon R. Pulley, Jon S. Jacobs, James P. Beck, Varghese John
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Publication number: 20040039040Abstract: Disclosed are novel urea derivatives and their medical uses, especially as adhesion molecule inhibitors useful for therapies of inflammatory diseases.Type: ApplicationFiled: March 14, 2003Publication date: February 26, 2004Inventors: Toshiya Takahashi, Takeshi Ishigaki, Miyuki Funahashi, Koji Taniguchi, Masayuki Kaneko, Mie Kainoh, Hiroyuki Meguro
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Publication number: 20040034096Abstract: The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula 1Type: ApplicationFiled: July 3, 2003Publication date: February 19, 2004Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
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Patent number: 6686493Abstract: The present invention relates to a novel 3,4-dihydro-1H-naphthalene derivative having a structure of formula 1 or formula 2, its pharmaceutically acceptable salts and their geometric isomers as a highly selective cyclooxygenase-2 inhibitor. Wherein, R1, R2, X, A and Q are defined in this specification respectively.Type: GrantFiled: October 3, 2002Date of Patent: February 3, 2004Assignee: Cheil Jedang CorporationInventors: Il Hwan Cho, Jee Woong Lim, Ji Young Noh, Jong Hoon Kim, Sang Wook Park, Hyung Chul Ryu, Je Hak Kim, Hyung Ok Chun, So Young Wang, Sung Hak Lee
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Patent number: 6667412Abstract: The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.Type: GrantFiled: August 27, 2001Date of Patent: December 23, 2003Assignee: Eisai Co., Ltd.Inventors: Yuichi Suzuki, Noboru Yamamoto, Koki Kawano, Teiji Kimura, Koichi Ito, Satoshi Nagato, Yoshihiko Norimine, Yoichi Iimura
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Publication number: 20030207344Abstract: Ethers and esters of cyanohydrins that contain optically detectable moieties are highly effective for detecting, monitoring, and measuring the activity of enzymes that cause the cleavage of certain types of substrates. The cyanohydrins function as proaldehydes and proketones, spontaneously converting to aldehydes and ketones, respectively, which provide a large increase in optical detectability relative to both the starting esters and ethers and the cyanohydrins.Type: ApplicationFiled: January 7, 2003Publication date: November 6, 2003Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Bruce D. Hammock, Guomin Shan, Rong Zhang
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Patent number: 6444838Abstract: The present invention provides a process for the preparation of pesticidal 1,4-diaryl-2-fluoro-4-cyano-2 -butene compounds having the structural formula I and intermediates useful therefor.Type: GrantFiled: May 4, 2001Date of Patent: September 3, 2002Assignee: BASF AktiengesellschaftInventors: Yulin Hu, David Allen Hunt
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Patent number: 6399776Abstract: This invention relates to novel processes for preparing the pharmaceutically active compound 5-(3-[(2S)-exo-bicyclo[2.2.1]hept-2-yloxy]-4-methoxyphenyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one and its corresponding 2R enantiomer and for preparing certain intermediates used in the synthesis of these compounds. It also relates to novel intermediates used in the synthesis of such pharmaceutically active compounds and to other novel compounds that are related to such intermediates.Type: GrantFiled: June 11, 2001Date of Patent: June 4, 2002Assignee: Pfizer INCInventors: Thomas G. LaCour, Charles William Murtiashaw, III
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Publication number: 20020002177Abstract: Novel indane and indene derivatives are described which are endothelin receptor antagonists.Type: ApplicationFiled: July 10, 2001Publication date: January 3, 2002Applicant: SmithKline Beecham CorporationInventors: Russell Donovan Cousins, John Duncan Elliott, Maria Amparo Lago, Jack Dale Leber, Catherine Elizabeth Peishoff
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Publication number: 20010014697Abstract: 2-Methoxyethoxy-benzenes are obtained in an advantageous manner from the corresponding phenol compounds by reaction with 2-chloroethyl methyl ether if the process is carried out without the addition of a strong solvent at temperatures above 95° C. and under pressure. The present invention also relates to novel 2-methoxyethoxy-benzyl cyanides.Type: ApplicationFiled: January 30, 2001Publication date: August 16, 2001Inventors: Guido Giffels, Claus Dreisbach