Plural Alicyclic Rings In Acid Moiety Patents (Class 560/116)
  • Patent number: 9029414
    Abstract: The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.
    Type: Grant
    Filed: September 19, 2009
    Date of Patent: May 12, 2015
    Assignee: Biotechnology Research Corporation
    Inventors: Nancy Yuk-Yu Ip, Fanny Chui-Fun Ip, Yueqing Hu
  • Patent number: 8987502
    Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel amidated derivatives of oleanolic acid according to formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.
    Type: Grant
    Filed: November 30, 2012
    Date of Patent: March 24, 2015
    Assignee: Hangzhou Bensheng Pharmaceutical Co., Ltd.
    Inventors: Frank Rong, Rongzhen Xu, Fuwen Xie, Hongxi Lai
  • Patent number: 8969617
    Abstract: The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: March 3, 2015
    Assignee: Kaohsiung Medical University
    Inventors: Chun-Nan Lin, Dravidum Maitraie, Jih-Pyang Wang, Chi-Feng Hung, Huang-Yao Tu, Ya-Ting Liou, Bai-Luh Wei, Shyh-Chyun Yang
  • Patent number: 8921419
    Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
    Type: Grant
    Filed: May 8, 2012
    Date of Patent: December 30, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu, Michael B. Sporn, Karen T. Liby
  • Publication number: 20140357711
    Abstract: Methods for synthesizing amooranin (25-hydroxy-3-oxoolean-12-en-28-oic acid (AMR) and/or amooranin analogs, including amooranin methyl ester (AMR-Me), by using oleanolic acid in an oxidation process, and therapeutic uses thereof are described.
    Type: Application
    Filed: December 21, 2012
    Publication date: December 4, 2014
    Applicants: ENZYME BIO SYSTEMS, NORTHEAST OHIO MEDICAL UNIVERSITY
    Inventors: Anupam Bishayee, Ashot Martirosian, Anushavan Yeranosyan
  • Publication number: 20140343064
    Abstract: The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-substituted oleanolic acid derivatives of formula (I) or a pharmaceutically acceptable salt thereof, to a process for the preparation of these compounds, compositions containing such compounds and their use in preparing antineoplastic medicaments.
    Type: Application
    Filed: November 30, 2012
    Publication date: November 20, 2014
    Applicant: Hanghzhou Bensheng Pharmaceutical Co., Ltd
    Inventors: Rongzhen Xu, Frank Rong, Hongxi Lai, Fuwen Xie
  • Publication number: 20140296561
    Abstract: A sulfonium salt having a 4-fluorophenyl group is introduced as recurring units into a polymer comprising hydroxyphenyl(meth)acrylate units and acid labile group-containing (meth)acrylate units to form a polymer which is useful as a base resin in a resist composition. The resist composition has a high sensitivity, high resolution and minimized LER.
    Type: Application
    Filed: June 17, 2014
    Publication date: October 2, 2014
    Inventors: Youichi OHSAWA, Masaki OHASHI, Seiichiro TACHIBANA, Jun HATAKEYAMA
  • Patent number: 8802352
    Abstract: A salt represented by formula (I): wherein Q1, Q2, L1, W, and Z+are defined in the specification.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: August 12, 2014
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Koji Ichikawa, Yuichi Mukai, Isao Yoshida
  • Publication number: 20140212750
    Abstract: Disclosed is an anode active material for lithium secondary batteries that includes natural graphite particles consisting of spherical particles of agglomerated graphite sheets, outer surfaces of which are not coated with a carbon-based material, wherein the surfaces of the particles have a degree of amorphization of at least 0.3 within a range within which an R value [R=I1350/I1580] (I1350 is the intensity of Raman around 1350 cm?1 and I1580 is the intensity of Raman around 1580 cm?1) of a Raman spectrum is in the range of 0.30 to 1.0.
    Type: Application
    Filed: March 31, 2014
    Publication date: July 31, 2014
    Applicant: LG CHEM, LTD.
    Inventors: Byoung Hoon Ahn, Chang-Wan Koo, Joon Sung Bae, Jae Bin Chung
  • Publication number: 20140179928
    Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: April 22, 2013
    Publication date: June 26, 2014
    Applicant: REATA PHARMACEUTICALS, INC.
    Inventors: Eric ANDERSON, Xin JIANG, Xiaofeng LIU, Melean VISNICK
  • Publication number: 20140142334
    Abstract: Disclosed are ester compounds of the formulae wherein Rc is alkylene, arylene, arylalkylene, or alkylarylene as further defined herein, Rd is alkylene, arylene, arylalkylene, or alkylarylene as further defined herein, and m and n are integers representing the numbers of repeat monomer units. The materials are suitable for use in inks and other applications.
    Type: Application
    Filed: November 19, 2012
    Publication date: May 22, 2014
    Applicant: Xerox Corporation
    Inventors: Rina Carlini, Adela Goredema
  • Publication number: 20140138582
    Abstract: A liquid crystal compound having high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large negative dielectric anisotropy, a suitable elastic constant and excellent compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound, and a liquid crystal display device including the composition. The compound is represented by formula (1-1): wherein, for example, R1 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 2 to 10 carbons; R2 is alkyl having 1 to 10 carbons, alkoxy having 1 to 9 carbons or alkenyl having 3 to 10 carbons; ring A1 is 1,4-cyclohexylene or 1,4-phenylene; ring A2 is 1,4-cyclohexylene, 1,4-phenylene or 2,3-difluoro-1,4-phenylene; Z1 and Z2 are single bonds; L1 and L2 are fluorine; and 1 is 0, 1 or 2.
    Type: Application
    Filed: November 15, 2013
    Publication date: May 22, 2014
    Applicants: JNC PETROCHEMICAL CORPORATION, JNC CORPORATION
    Inventors: Yasuyuki GOTOH, Masahide KOBAYASHI
  • Publication number: 20140100384
    Abstract: Provided is a process for making non-phthalate plasticizers, by acylating an aromatic compound with a succinic anhydride to form a keto-acid, and then esterifying the keto-acid with C4-C13 OXO-alcohols to form a plasticizer compound. The aromatic rings of the aromatic compound may also be optionally hydrogenated.
    Type: Application
    Filed: December 9, 2013
    Publication date: April 10, 2014
    Applicant: ExxonMobil Research and Engineering Company
    Inventors: Jihad Mohammed Dakka, Edmund John Mozeleski, Lisa Saunders Baugh, Colle Karla Schall, Allen David Godwin, Diana S. Smirnova, Jorg Friedrich Wilhelm Weber, Stephen Zushma
  • Patent number: 8686166
    Abstract: A 2,2-bis(fluoroalkyl)oxirane (A) is prepared by reacting a fluorinated alcohol (1) with a chlorinating, brominating or sulfonylating agent under basic conditions to form an oxirane precursor (2) and subjecting the oxirane precursor to ring closure under basic conditions. R1 and R2 are fluoroalkyl groups, R3 and R4 are hydrogen or monovalent hydrocarbon groups, X is chlorine, bromine or —OSO2R5 group, and R5 is alkyl or aryl.
    Type: Grant
    Filed: June 19, 2012
    Date of Patent: April 1, 2014
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Masayoshi Sagehashi, Takeru Watanabe, Youichi Ohsawa, Koji Hasegawa, Masaki Ohashi
  • Publication number: 20140088277
    Abstract: This invention relates to a reaction product obtained by contacting a polymer comprising units derived from dicyclopentadiene with a vinyl terminated macromonomer, a vinyl monomer or a vinylene monomer, in the presence of a metathesis catalyst, where the vinyl monomer or vinylene monomer is represented by the formula: wherein each X is, independently, —CO2R, —CONR1R2, CN, a C1 to a C20 alkyl group; R is a C1 to a C20 alkyl group or an aromatic group; each R1 and R2 is, independently, a hydrogen, a C1 to a C20 alkyl group, or an aromatic group; each R5 is, independently, a hydrogen atom or a C1 to a C40 alkyl group; each Ar is, independently, an aromatic group; and each n is, independently, from 0 to about 40.
    Type: Application
    Filed: September 19, 2013
    Publication date: March 27, 2014
    Inventors: Ian C. Stewart, John R. Hagadorn, Mun F. Tse, George Rodriguez, Patrick Brant
  • Patent number: 8624057
    Abstract: There is provided an isoprenoid according to the general formula (I) wherein R1 and R2 are independently selected from H and alkyl; and R3, R4, R5 and R6 are independently selected from groups of the general formula (II) and (III) wherein R7 and R8 each represent a group of general formula CO—R9, in which each R9 is independently selected from H, OH, alkyl and alkoxy groups, or R7 and/or R8 present in R3 and R4 and/or in R5 and R6 combine to form a group of the general formula (IV) wherein R10 is selected from OH and alkoxy; or salts thereof. The isoprenoids are of particular use in the preparation of liposomes, for use in the delivery of pharmaceutically active components to a subject human or animal.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: January 7, 2014
    Assignee: University of Plymouth
    Inventor: Steven John Rowland
  • Publication number: 20130345159
    Abstract: A cardiogenin major isomer is obtained from a methanol extract of Geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a Chiralpak® IC™ column. The purity of the isolated cardiogenin major isomer can be further increased by crystallization, yielding isolated cardiogenin major isomer having HPLC purity as high as 98.97% (a/a) at 210 nm and a potency of 95.50%) (w/w).
    Type: Application
    Filed: December 21, 2011
    Publication date: December 26, 2013
    Applicant: HUYA BIOSCIENCE INTERNATIONAL LLC
    Inventors: Andreas Kyas, Ernst Freund, Oliver Schlörke, Joerg Lill, Lars Rogall, Dario Menia, Gary Elliott, James Paterniti
  • Publication number: 20130317156
    Abstract: This invention relates to the new functional norbornanyl ester derivative and/or polymer compositions which are easily obtainable by reacting the Diels-Alder adduct of appropriate dienes and dienophiles with carboxylic acids. In particular, this invention relates to a new process for making cyclic chemical raw materials suitable for production coating, ink, adhesive, plasticizer, thermoplastic or thermosetting plastic and functional polymers.
    Type: Application
    Filed: May 25, 2012
    Publication date: November 28, 2013
    Applicant: New Functional Polymers LLC
    Inventor: Hui Yu
  • Publication number: 20130303607
    Abstract: The present invention provides triterpenoids produced from natural compounds such as oleanolic acid, ursolic acid, betulinic acid, and hederagenin.
    Type: Application
    Filed: May 8, 2012
    Publication date: November 14, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu, Michael B. Sporn, Karen T. Liby
  • Publication number: 20130303797
    Abstract: The present invention is a method for preparing triterpenoids such as 2-cyano-3,12-dioxoolean-1,9-dien-28-methyl ester and derivatives thereof from oleanic acid, ursolic acid, betulinic acid, sumaresinolic acid or hederagenin.
    Type: Application
    Filed: May 8, 2012
    Publication date: November 14, 2013
    Applicant: Trustees of Dartmouth College
    Inventors: Gordon W. Gribble, Liangfeng Fu
  • Publication number: 20130281726
    Abstract: To provide a method for recovering a precious metal from a solution containing precious metal ions, an extracting agent or adsorbent used therefor, and a back-extracting agent or desorbent. An extracting agent or adsorbent in which precious metal ions are extracted or adsorbed, is brought into contact with a back-extracting agent or desorbent containing a sulfur-containing amino acid derivative represented by the following formula (I): wherein R1 is a methyl group, an ethyl group, a vinyl group, a C3-8 linear, branched or cyclic hydrocarbon group, or a C6-14 aromatic hydrocarbon group, R2's are each independently a hydrogen atom, a methyl group, an ethyl group, a vinyl group, a C3-8 linear, branched or cyclic hydrocarbon group or a C6-14 aromatic hydrocarbon group, and n is 0 or 1, to obtain a solution containing the precious metal ions, which is subjected to a reduction treatment to obtain a precious metal.
    Type: Application
    Filed: December 28, 2011
    Publication date: October 24, 2013
    Applicant: TOSOH CORPORATION
    Inventors: Yukinori Suso, Takashi Sakaki
  • Publication number: 20130274256
    Abstract: Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.
    Type: Application
    Filed: October 11, 2012
    Publication date: October 17, 2013
    Applicant: SEQUOIA SCIENCES, INC.
    Inventor: Sequoia Sciences, Inc.
  • Publication number: 20130274329
    Abstract: Compounds selected from the group of N-unsubstituted or N-alkylated or N-acylated 14-O-[(amino(C0-4)alkyl-hydroxy-cycloalkyl- or bicycloalkylsulfanyl)-acetyl]-mutilins which are 14-O-[(amino(C0-4)alkyl-hydroxy-cyclobutylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclopentylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cycloheptylsulfanyl)-acetyl]-mutilins, 14-O-[(amino(C0-4)alkyl-hydroxy-cyclooctylsulfanyl)-acetyl]-mutilins, or 14-O-[(amino(C0-4)alkyl-hydroxy-bicycloalkylsulfanyl)-acetyl]-mutilins, optionally in the form of a salt and/or a solvate, a pharmaceutical compositions comprising such compounds and their use as pharmaceuticals, e.g. for the treatment of microbial infections and for the treatment of acne, optionally in combination with other pharmaceutically active agents.
    Type: Application
    Filed: August 11, 2011
    Publication date: October 17, 2013
    Applicant: NABRIVA THERAPEUTICS AG
    Inventors: Rosemarie Riedl, Klaus Thirring, Werner Heilmayer
  • Publication number: 20130165658
    Abstract: This invention is directed to a process for the preparation of high yield alkyl or aryl iodide from its corresponding carboxylic acid using N-iodo amides.
    Type: Application
    Filed: June 9, 2011
    Publication date: June 27, 2013
    Inventors: Gennady Nisnevich, Mark Gandelman, Kseniya Kulbitski
  • Patent number: 8440820
    Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: May 14, 2013
    Assignee: Reata Pharmaceuticals, Inc.
    Inventors: Eric Anderson, Xin Jiang, Xiaofeng Liu, Melean Visnick
  • Publication number: 20130109752
    Abstract: The present invention is correlated with a derivative of 18?-glycyrrhetinic acid apt to suppressing cancer cells, which is selected from a group comprising of structure I and structure II: wherein residue R1 is selected from one of CH3 and CH2C6H5, residue R2 is selected from one of COOCH3, COOCH2CH3, COOCH(CH3)2, CONHCH2CH3, CONHCH2CH2CH3, and CONHCH2(CH3)2, and residue R3 is selected from one of COOCH2CH3, COOCH(CH3)2, CONHCH2CH3, CONHCH2CH2CH3, and CONHCH2(CH3)2.
    Type: Application
    Filed: March 14, 2012
    Publication date: May 2, 2013
    Inventors: Chun-Nan Lin, Kai-Wei Lin, A-Mei Huang, Tzyh-Chyuan Hour, Shyh-Chyun Yang, Yeong-Shiau Pu, Jan-Gowth Chang
  • Patent number: 8420854
    Abstract: The present invention provides an optical anisotropic material having a good light stability, and provides a di(meth)acrylate compound represented by the following formula (1) and a polymerizable liquid crystalline composition that are suitable for the production of the optical anisotropic material. Further, the present invention provides an optical element having a good light stability and an optical information writing/reading device using the same.
    Type: Grant
    Filed: January 5, 2012
    Date of Patent: April 16, 2013
    Assignee: Asahi Glass Company, Limited
    Inventors: Satoshi Okada, Makoto Hasegawa, Hiroshi Kumai, Hiromichi Nagayama
  • Publication number: 20130079490
    Abstract: A norbornane-2-spiro-?-cycloalkanone-??-spiro-2?-norbornane-5,5?,6,6?-tetracarboxylic dianhydride represented by the following general formula (1): [in the formula (1), n represents an integer of 0 to 12, and R1s, R2, R3 each independently represents a hydrogen atom or the like].
    Type: Application
    Filed: February 9, 2011
    Publication date: March 28, 2013
    Applicants: TOKYO POLYTECHNIC UNIVERSITY, JX NIPPON OIL & ENERGY CORPORATION
    Inventors: Toshihiko Matsumoto, Shinichi Komatsu
  • Publication number: 20130072694
    Abstract: The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.
    Type: Application
    Filed: November 13, 2012
    Publication date: March 21, 2013
    Applicant: Kaohsiung Medical University
    Inventor: Kaohsiung Medical University
  • Patent number: 8389573
    Abstract: The present invention relates to novel derivatives of glycyrrhetinic acid, compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR&ggr; and/or a downregulation of the expression or activity of one or more specificity (Sp) proteins, such as cancer, diabetes and Huntington's disease.
    Type: Grant
    Filed: June 27, 2007
    Date of Patent: March 5, 2013
    Assignees: Wellington Laboratories Inc., The Texas A&M University System
    Inventors: Stephen H. Safe, Sudhakar Chintharlapalli, Alan McAlees, Robert McCrindle
  • Publication number: 20130045898
    Abstract: There is disclosed use of hyperbranched polyester amides as a foamer to stabilize mixtures of oil and water especially for mixtures found in gas and/or oil wells to facilitate extraction of the well contents.
    Type: Application
    Filed: November 25, 2010
    Publication date: February 21, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Stijn Witters, Franciscus Johannes Marie Derks
  • Patent number: 8373004
    Abstract: The present invention relates to a novel process for preparing colorless, isocyanurate group-comprising polyisocyanates of (cyclo)aliphatic diisocyanates.
    Type: Grant
    Filed: March 27, 2008
    Date of Patent: February 12, 2013
    Assignee: BASF SE
    Inventors: Harald Schaefer, Carl Jokisch, Horst Binder, Matthias Kroner, Alexander Bayer
  • Patent number: 8338618
    Abstract: Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: December 25, 2012
    Assignee: Reata Pharmaceuticals, Inc.
    Inventors: Xin Jiang, Jack Greiner, Lester L. Maravetz, Stephen S. Szucs, Melean Visnick
  • Patent number: 8329940
    Abstract: The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: December 11, 2012
    Assignee: Kaohsiung Medical University
    Inventors: Chun-Nan Lin, Dravidum Maitraie, Jih-Pyang Wang, Chi-Feng Hung, Huang-Yao Tu, Ya-Ting Liou, Bai-Luh Wei, Shyh-Chyun Yang
  • Patent number: 8263793
    Abstract: The present invention relates to a new process for the preparation of 9-dihydrobaccatin III intermediates as useful precursors for the preparation of paclitaxel, 1, docetaxel, 2, and analogues thereof. More particularly, the process comprises the steps of (i) concomitantly deacetylating esters at the 10-position and 13-position of 9-dihydro-13-acetylbaccatin III to form 9-dihydro-10-deacetylbaccatin III; (ii) protecting a hydroxy group at the 7-position of 9-dihydro-10-deacetylbaccatin III; and (iii) acylating a hydroxy group at the 10-position to form a compound of formula II.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: September 11, 2012
    Assignee: Accord Healthcare Inc.
    Inventors: Gaetan Caron, Mettilda Lourdusamy
  • Patent number: 8217137
    Abstract: The present invention is directed to a series of new compounds, combining the unique properties of fullerenes and bio-active amino acid residues, and to methods for making such compounds. The present invention is directed toward fullerene-based amino acids, and to amino acid residues, peptide chains, proteins, and polypeptides made from such fullerene-based amino acids. The present invention is further directed to amino acid residues, peptide chains, proteins, and polypeptides comprising such fullerene-based amino acids and into which such fullerene-based amino acids have been incorporated. Exemplary compounds have been prepared, and these compounds have been characterized and confirmed with infrared (IR) spectroscopy, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), etc.
    Type: Grant
    Filed: January 14, 2005
    Date of Patent: July 10, 2012
    Assignee: William Marsh Rice University
    Inventors: Andrew R. Barron, Jianzhong Yang
  • Publication number: 20120172337
    Abstract: The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 5, 2012
    Applicant: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Publication number: 20120149768
    Abstract: The present invention relates to methods of activate an isoform of protein kinase C (PKC) for the treatment of neurological diseases including Alzheimer's disease and stroke using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids. The present invention also relates to methods of reducing neurodegeneration using cyclopropanated or epoxidized derivatives of mono- and polyunsaturated fatty acids.
    Type: Application
    Filed: February 21, 2012
    Publication date: June 14, 2012
    Inventors: Thomas J. Nelson, Daniel L. Alkon
  • Publication number: 20120053141
    Abstract: The present invention pertains to novel uses of glycyrrhetinic acid (GA), glycyrrhizic acid (GLA) and related compounds for prevention and/or treatment of pulmonary fibrosis, in particular, irradiation-induced pulmonary fibrosis. Also embodied are therapeutic uses of prodrugs, metabolites, derivatives (e.g., acids, esters and ethers), and salts of glycyrrhetinic acid (GA) and glycyrrhizic acid (GLA). The present invention also provides for therapeutic or pharmaceutical compositions comprising a compound of the invention in a form that can be combined with a pharmaceutically acceptable carrier.
    Type: Application
    Filed: August 25, 2010
    Publication date: March 1, 2012
    Inventors: Lurong ZHANG, Weijian Zhang, Jianhua Xu, Shanmin Yang
  • Publication number: 20120035260
    Abstract: Use of tellurium-containing compounds in a method of conception and/or for maintaining and/or augmenting fertility in female following chemotherapy and/or radiotherapy is disclosed. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and/or radiation, such that the female treated by the chemotherapeutic agent and/or radiation and by the tellurium-containing compound is instructed to refrain from conceptive sex for a pre-determined time period, following the chemotherapy and/or radiotherapy, during which conception is undesired. The tellurium-containing compound is utilized in combination with a chemotherapeutic agent and/or radiation, such that the female treated by the chemotherapeutic agent and/or radiation and by the tellurium-containing compound is instructed to refrain from sex and/or from reproduction for a pre-determined time period, and is then allowed to practice reproduction.
    Type: Application
    Filed: January 7, 2010
    Publication date: February 9, 2012
    Applicant: BIOMAS LTD.
    Inventors: Benjamin Sredni, Dror Meirow, Michael Albeck, Benjamin Ron
  • Publication number: 20110319454
    Abstract: The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 29, 2011
    Applicant: ALLERGAN, INC.
    Inventors: Richard L. Beard, John E. Donello, Vidyasagar Voligonda, Michael E. Garst
  • Patent number: 8071270
    Abstract: The present invention provides a polyhydric compound represented by the formula (I): wherein R51 to R67 each independently represent a hydrogen atom etc., at least one selected from the group consisting of R1 to R5 is a group represented by the formula (II): wherein Q1 and Q2 each independently represent a fluorine atom etc., U represents a C1-C20 divalent hydrocarbon group etc., and A+ represents an organic counter ion, and the others are hydrogen atoms or groups represented by the formula (III): wherein X1 to X4 each independently represent a hydrogen atom etc., n represents an integer of 0 to 3, W represents any one of the following groups: Z1 represents a C1-C6 alkyl group etc., and ring Y represents a C3-C20 alicyclic hydrocarbon group, and a chemically amplified resist composition containing the same.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: December 6, 2011
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Ichiki Takemoto, Nobuo Ando
  • Patent number: 8067630
    Abstract: A method for forming cascade polymers specifically utilizing the amine monomer of the formula The monomer is made by initially reacting nitromethane and CH2?CHCO2—TBu by nucleophilic addition to form the triester nitrotrialkanoate of the formula and then reducing the nitrosubstituent to afford the said amine monomer.
    Type: Grant
    Filed: September 15, 2009
    Date of Patent: November 29, 2011
    Assignee: University of South Florida
    Inventors: George R. Newkome, Charles N. Moorefield, Rajani K. Behera
  • Publication number: 20110288169
    Abstract: The present invention provides therapeutically active compounds and compositions as receptor antagonists and methods of use thereof. In one aspect, the compounds are useful in modulating pain, inflammation and acute phase reactions by inhibiting the PGE2 receptors including PGE2 EP1, EP2 and EP4 receptors.
    Type: Application
    Filed: September 19, 2009
    Publication date: November 24, 2011
    Inventors: Nancy Yuk-Yu Ip, Fanny Chui-Fun Ip, Yueqing Hu
  • Publication number: 20110274656
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating Hepatitis C, comprising the roots extract of Platycodon grandiflorum and/or saponin components in Platycodon grandiflorum useful as an antiviral agent. The composition of the present invention has no harm to human and inhibits the proliferation of Hepatitis C virus, so that it can be effectively used as a preventive or therapeutic agent for Hepatitis C.
    Type: Application
    Filed: January 21, 2010
    Publication date: November 10, 2011
    Applicant: B&C Biopharm Co., Ltd.
    Inventors: Jong Woo Kim, Sang Wook Lee, Sang Jin Park, Jung Cheul Shin, Jae Won Yang, Jong Hwan Lim
  • Patent number: 8043789
    Abstract: A photosensitive compound whose size is smaller than conventional polymer for photoresist, and which has well-defined (uniform) structure, and a photoresist composition including the same are disclosed. The photosensitive compound represented by the following formula. Also, the present invention provides a photoresist composition comprising 1 to 85 wt % (weight %) of the photosensitive compound; 0.05 to 15 weight parts of a photo-acid generator with respect to 100 weight parts of the photosensitive compound; and 10 to 5000 weight parts of an organic solvent. In the formula, n is 0 or 1, x is 1, 2, 3, 4 or 5, y is 2, 3, 4, 5 or 6, z is 0, 1, 2, 3 or 4, R, R? and R? are independently hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms, and R?? is a hydrogen atom or hydrocarbon group of 1 to 30 carbon atoms, preferably 2 to 20 carbon atoms.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: October 25, 2011
    Assignee: Dongjin Semichem Co., Ltd.
    Inventors: Jae-Woo Lee, Min-Ja Yoo, Jun-Gyeong Lee, Young-Bae Lim, Jae-Hyun Kim
  • Publication number: 20110232178
    Abstract: Compounds and methods that release 1-methylcyclopropene, 1-trifluoromethylcyclopropene, and other substituted cyclopropenes are disclosed. The compounds and methods overcome present limitations for storage, transportation, and application of the cyclopropene containing compounds by using light, including sunlight, and/or heat as the primary release trigger. Additional products released include innocuous gases and value added aryl-group compounds.
    Type: Application
    Filed: March 23, 2011
    Publication date: September 29, 2011
    Inventors: John Perrin Davis, Cheryl D. Stevenson
  • Publication number: 20110152564
    Abstract: A resin production apparatus of the present invention includes: a reactor vessel having a vessel main body which polymerizes an ingredient to produce a thermoplastic synthetic resin which solidifies at room temperature and storing the synthetic resin in the molten state, an output mechanism disposed at a bottom part of the vessel main body, which outputs the synthetic resin in the molten state, and a temperature adjustment mechanism which adjusts temperatures of the vessel main body and the output mechanism so as to maintain the molten state of the synthetic resin; a cooling mechanism arranged below the reactor vessel, which continuously cools and solidifies the synthetic resin output from the output mechanism; and a crushing mechanism which crushes the synthetic resin fed out from the cooling mechanism.
    Type: Application
    Filed: November 15, 2010
    Publication date: June 23, 2011
    Applicant: NITTO DENKO CORPORATION
    Inventors: Shuzo FUJIWARA, Yasuhide SUZUKI, Yasuhiko OKUDA, Tetsuya HIROSE
  • Patent number: 7915402
    Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: April 20, 2009
    Date of Patent: March 29, 2011
    Assignee: Reata Pharmaceuticals, Inc.
    Inventors: Eric Anderson, Xin Jiang, Xiaofeng Liu, Melean Visnick
  • Publication number: 20110069241
    Abstract: A liquid crystal compound having a good durability against light, a polymerizable liquid crystal composition and an optically anisotropic material are provided. Further, an optical element having a good durability against light and an optical information writing/reading device employing such an element are provided. The liquid crystal compound is represented by a general formula CH2?CR1—COO-(L)k-E1-E2-(E3)m-R2. E1 is preferably a trans-2,6-decahydronaphthalene group and E2 is preferably a trans-1,4-cyclohexylene group. A phase difference plate 4 produced by employing the compound has a good durability against light, and accordingly, it is possible to achieve an optical head device employing a blue laser as a light source 1 and being suitable for large capacity writing/reading.
    Type: Application
    Filed: December 2, 2010
    Publication date: March 24, 2011
    Applicant: ASAHI GLASS COMPANY, LIMITED
    Inventors: Satoshi Okada, Makoto Hasegawa, Hiroshi Kumai