Plural Alicyclic Rings In Acid Moiety Patents (Class 560/116)
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Publication number: 20110069241Abstract: A liquid crystal compound having a good durability against light, a polymerizable liquid crystal composition and an optically anisotropic material are provided. Further, an optical element having a good durability against light and an optical information writing/reading device employing such an element are provided. The liquid crystal compound is represented by a general formula CH2?CR1—COO-(L)k-E1-E2-(E3)m-R2. E1 is preferably a trans-2,6-decahydronaphthalene group and E2 is preferably a trans-1,4-cyclohexylene group. A phase difference plate 4 produced by employing the compound has a good durability against light, and accordingly, it is possible to achieve an optical head device employing a blue laser as a light source 1 and being suitable for large capacity writing/reading.Type: ApplicationFiled: December 2, 2010Publication date: March 24, 2011Applicant: ASAHI GLASS COMPANY, LIMITEDInventors: Satoshi Okada, Makoto Hasegawa, Hiroshi Kumai
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Publication number: 20110052513Abstract: The present patent application relates to novel surface-active cationic compounds, to their use, in particular as hair conditioning agent, to a cosmetic treatment method, in particular for the hair, employing the said compounds, and to the cosmetic or pharmaceutical compositions, in particular hair compositions, comprising the said surfactants.Type: ApplicationFiled: February 3, 2009Publication date: March 3, 2011Applicant: L' OrealInventors: Laure Ramos-Stanbury, Herve Andrean, Christian Blaise
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Publication number: 20110038794Abstract: The present invention relates to a method of radiolabelling carbon nanotubes, to the radiolabelled carbon nanotubes that can be obtained by implementing this method, and to applications thereof.Type: ApplicationFiled: November 6, 2008Publication date: February 17, 2011Applicant: Commissariat ! L'Energie Atomique Et Aux Engeries AlternativesInventors: Frederic Taran, Dominique Georgin
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Publication number: 20110039922Abstract: The present invention provides a chemical compound having the structure being one selected from a group consisting of wherein R1 is one selected from a group consisting of COOCH3, COOCH2Ph, CONHCH(CH3)2 and CONHC6H5, R2 is one selected from a group consisting of H, CH3 and CH(CH3)2, R3 is one selected from a group consisting of H, CH3, CH(CH3)2 and CH2Ph, and R4 is one of CH(CH3)2 and C6H5.Type: ApplicationFiled: December 30, 2009Publication date: February 17, 2011Applicant: KAOHSIUNG MEDICAL UNIVERSITYInventors: Chun-Nan Lin, Dravidum Maitraie, Jih-Pyang Wang, Chi-Feng Hung, Huang-Yao Tu, Ya-Ting Liou, Bai-Luh Wei, Shyh-Chyun Yang
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Publication number: 20110028522Abstract: Described herein are methods for treating inflammatory disorders. The methods comprise administering to a subject in need thereof a therapeutically effective amount of a synthetically modified fullerene.Type: ApplicationFiled: March 3, 2009Publication date: February 3, 2011Applicant: LUNA INNOVATIONS INCORPORATEDInventors: Christopher L. Kepley, Robert P. Lenk, Stephen R. Wilson, Zhiguo Zhou, Darren K. MacFarland
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Patent number: 7868199Abstract: Fluoroalcohol compounds of formula (4) are prepared by reacting a fluorine compound of formula (1) with reducing agents or organometallic reagents of formulas (2) and (3) wherein R1 is H or a monovalent C1-C20 hydrocarbon group in which any —CH2— moiety may be replaced by —O— or —C(?O)—, R2 is H or a monovalent C1-C6 hydrocarbon group, R3 and R4 are H or a monovalent C1-C8 hydrocarbon group, and M1 is Li, Na, K, Mg, Zn, Al, B, or Si. From the fluoroalcohol compounds, fluorinated monomers can be produced in a simple and economic way, which are useful in producing polymers for the formulation of radiation-sensitive resist compositions.Type: GrantFiled: January 30, 2007Date of Patent: January 11, 2011Assignee: Eudyna Devices Inc.Inventors: Koji Hasegawa, Takeshi Kinsho, Tsunehiro Nishi, Masaki Ohashi, Takeru Watanabe
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Publication number: 20100305129Abstract: There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and compositions comprising acetyl isogambogic acid, celastrol, or a derivative thereof.Type: ApplicationFiled: August 11, 2010Publication date: December 2, 2010Applicant: Burnham Institute for Medical ResearchInventors: Zéev A. Ronai, Anindita Bhoumik, Nicholas D.P. Cosford, Russell Dahl
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Publication number: 20100297217Abstract: There is provided an isoprenoid according to the general formula (I) wherein R1 and R2 are independently selected from H and alkyl; and R3, R4, R5 and R6 are independently selected from groups of the general formula (II) and (III) wherein R7 and R8 each represent a group of general formula CO—R9, in which each R9 is independently selected from H, OH, alkyl and alkoxy groups, or R7 and/or R8 present in R3 and R4 and/or in R5 and R6 combine to form a group of the general formula (IV) wherein R10 is selected from OH and alkoxy; or salts thereof. The isoprenoids are of particular use in the preparation of liposomes, for use in the delivery of pharmaceutically active components to a subject human or animal.Type: ApplicationFiled: March 19, 2008Publication date: November 25, 2010Inventor: Steven John Rowland
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Publication number: 20100273801Abstract: The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.Type: ApplicationFiled: June 6, 2007Publication date: October 28, 2010Applicant: Valition teknillinen tutikimuskeskusInventors: Jari Yli-Kauhaluoma, Salme Koskimies, Sami Alakurtti, Taru Mäkelä, Päivi Tammela
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Publication number: 20100267983Abstract: The invention discloses water-soluble triterpenephenol compounds having antitumor activity represented by formula (I), wherein the substituents R1˜R4 and M are defined as in the description. The invention also discloses a method for preparing the compounds of formula (I) used quinone methide triterpene compounds as starting materials. The water-soluble triterpenephenol compounds disclosed in the invention can be made into various dosage forms including injection, tablet, capsule, granule and liniment, particularly suitable for making into injection.Type: ApplicationFiled: November 5, 2008Publication date: October 21, 2010Applicant: SHANGHAI HUATUO MEDICAL SCIENCE CO., LTDInventors: Jiafeng Zeng, Junfang Pan, Baoying Li, Qin Zhu, Tong Fang, Huiyan Ni
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Patent number: 7799950Abstract: A diamine includes a structure of formula (I), wherein X and Y are independently a divalence group selected from the group consisting of: —O—, —(C?O)—O—, —O—(C?O)—, —(C?O)—NH—, and —NH—(C?O)—; and R has a structure of formula (II): wherein R1, R2, R3, R4, R5, m, and n are as defined in Claim 1. A polyamic acid is prepared by reacting a diamine reactant including the aforesaid diamine of formula (I) with a tetracarboxylic dianhydride reactant. A liquid crystal orienting film contains a polyimide converted from the aforesaid polyamic acid.Type: GrantFiled: May 9, 2007Date of Patent: September 21, 2010Assignee: Daily Polymer Co., Ltd.Inventors: Chuan-Ter Yan, Chih-Hsiung Huang, Chao-Ching Huang, Chin-Wang Kao, Tin-Hun Hung
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Patent number: 7786314Abstract: Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.Type: GrantFiled: November 3, 2004Date of Patent: August 31, 2010Assignee: Taisho Pharmaceutical Co., LtdInventors: Frederick W. Hartner, Lushi Tan, Nobuyoshi Yasuda, Naoki Yoshikawa
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Publication number: 20100190985Abstract: This invention is related to heteroatom containing diamondoids (i.e., “heterodiamondoids”) which are compounds having a diamondoid nucleus in which one or more of the diamondoid nucleus carbons has been substitutionally replaced with a noncarbon atom. These heteroatom substituents impart desirable properties to the diamondoid. In addition, the heterodiamondoids are functionalized affording compounds carrying one or more functional groups covalently pendant therefrom. This invention is further related to polymerizable functionalized heterodiamondoids. In a preferred aspect of this invention the diamondoid nuclei are triamantane and higher diamondoid nuclei. In another preferred aspect, the heteroatoms are selected to give rise to diamondoid materials which can serve as n- and p-type materials in electronic devices can serve as optically active materials.Type: ApplicationFiled: December 14, 2009Publication date: July 29, 2010Applicant: Chevron U.S.A. Inc.Inventors: Shenggao Liu, Robert M. Carlson, Jeremy E. Dahl
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Publication number: 20100092418Abstract: The present invention is directed to a fragrance compound of bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, ethyl ester: and its isomeric compounds.Type: ApplicationFiled: October 14, 2008Publication date: April 15, 2010Inventors: Adam P. Closson, Anthony T. Levorse, JR., Michael G. Monteleone
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Publication number: 20100056777Abstract: This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.Type: ApplicationFiled: April 20, 2009Publication date: March 4, 2010Inventors: Eric Anderson, Xin Jiang, Xiaofeng Liu, Melean Visnick
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Publication number: 20100048911Abstract: Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.Type: ApplicationFiled: April 20, 2009Publication date: February 25, 2010Inventors: Xin Jiang, Jack Greiner, Lester L. Maravetz, Stephen S. Szucs, Melean Visnick
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Publication number: 20100036153Abstract: The invention at hand provides at least dinitroxylated diamantanes. In addition, it provides methods for producing substituted diamantanes with high yields and selectivity. According to the invention, dinitroxylated diamantanes are suitable for being reacted with nucleophiles to form the corresponding disubstituted diamantanes. Surprisingly, it was discovered that at least dinitroxylated or hydroxylated diamantanes are rearranged in the presence of a strong acid, creating at least 4,9-nitroxylated or hydroxylated diamantanes. On the basis of this, 4,9-substituted diamantanes are able to be produced in a targeted manner by reaction with further nucleophiles.Type: ApplicationFiled: December 4, 2006Publication date: February 11, 2010Inventors: Peter R. Schreiner, Andrey A. Fokin
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Publication number: 20090318551Abstract: This invention relates to novel AKBA analogs of the formula I given below: Where in R1, R2, R3, R4 and R5 in each of the said analogs are: 1. R1?OCHO, R2?H, R3?COOH, R4 & R5?O 2. R1?OCOCH2Cl, R2?H, R3?COOH, R4 & R5?O 3. R1=5?-O-methylgalloyloxy, R2?H, R3?COOH, R4 & R5?O 4. R1?OCOCH2CH2COOH, R2?H, R3?COOH, R4 & R5?O 5. R1=8?,9?-Dihydro-4?-hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 6. R1=4?-Hydroxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 7. R1=3?,4?-Dimethoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 8. R1=3?,4?-Dihydroxy-5?-methoxycinnamoyloxy, R2?H, R3?COOH, R4 & R5?O 9. R1?OCOCH2NH(tert-BOC), R2?H, R3?COOCH3, R4 & R5?O 10. R1?OCOCH2NH2HCl, R2?H, R3?COOH, R4 & R5?O 11. R1?OCOCH(CH3)NH2HCl, R2?H, R3?COOH, R4 & R5?O 12. R1?H, R2?OH, R3?COOCH3, R4 & R5?O 13. R1?H, R2?Br, R3?COOCH3, R4 & R5?O 14. R1?CN, R2?H, R3?COOCH3, R4 & R5?O 15. R1?SH, R2?H, R3?COOCH3, R4 & R5?O 16. R1 & R2?N(OH), R3?COOCH3, R4 & R5?O 17.Type: ApplicationFiled: August 28, 2009Publication date: December 24, 2009Inventors: Ganga Raju Gokaraju, Rama Raju Gokaraju, Venkata Subbaraju Gottumukkala, Trimurtulu Golakoti
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Publication number: 20090272295Abstract: A coating material including a low-molecular or medium-molecular organic compound represented by general formula (1). (In the formula, R1 is a single bond, methylene, ethylene or oxygen; and R2 is a hydrogen atom, or a hydrocarbon group, a fluorine-containing alkyl group, a cyclic form containing an aromatic group or aliphatic group, which may contain hydroxy group, carboxyl group, amino group, amide group, imide group, glycidyl group, cyano group, fluorocarbinol group, sulfonic group or sulfonylamide group, and a complex thereof, and may contain a fluorine atom, oxygen atom, nitrogen atom, silicon atom or sulfur atom, and R2's of the same type or different type may be connected by an ester bond, amide bond, ether bond, thioether bond, thioester bond or urethane bond.). This compound can be derived from a diol compound and bicyclo[2.2.2]octane-2,3:5,6-tetracarboxylic anhydride.Type: ApplicationFiled: September 5, 2006Publication date: November 5, 2009Applicant: CENTRAL GLASS COMPANY, LIMITEDInventors: Satoru Miyazawa, Satoru Kobayashi, Kazuhiko Maeda
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Patent number: 7592478Abstract: Novel ligand antagonists of the RAR receptors have the following structural formula (I): in which A is a CH2, CHOH, C?O or C?N—OH radical or a sulfur or selenium atom; B is a radical selected from among those of formulae (a) to (f): and Ar is a radical selected from among those of formulae (g) to (i):Type: GrantFiled: October 30, 2007Date of Patent: September 22, 2009Assignee: Galderma Research & DevelopmentInventors: Philippe Diaz, Catherine Raffin, Thibaud Biadatti
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Publication number: 20090203634Abstract: Amooranin (AMR) has been found to cause tumor cell death through G2/M cell cycle arrest, caspase activation, and apoptosis. Furthermore, it has been demonstrated that AMR is a substrate for P-glycoprotein. Based on these activities, AMR compounds, including AMR analogs, can be used in the treatment of a number of diseases in which aberrant cellular proliferation occurs such as drug-sensitive and drug-resistant cancers, autoimmune disorders, and inflammatory diseases.Type: ApplicationFiled: April 14, 2006Publication date: August 13, 2009Applicant: Variety Children's Hospital d/b/a Miami Children's HospitalInventors: Cheppail Ramachandran, P.K. Raveendran Nair, Steven J. Melnick
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Publication number: 20090198065Abstract: To provide a resist polymer comprising, as a structural unit, an acid-decomposable unit having a structure represented by formula (1) or (2) which exhibits a small line edge roughness and produces little defects in DUV excimer laser lithography or the like.Type: ApplicationFiled: March 26, 2009Publication date: August 6, 2009Applicant: Mitsubishi Rayon Co., Ltd.Inventors: Hikaru Momose, Atsushi Ootake, Tadashi Nakamura, Akifumi Ueda
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Publication number: 20090156856Abstract: The present invention provides a lubricating oil comprising an alicyclic compound represented by a general formula (I): wherein n is an integer of 0 or 1; one of R1 and R2 represents —CH2OR4 (wherein R4 represents a carboxylic acid residue) while the other one represents alkyl, lower alkyl-substituted or unsubstituted cycloalkyl, aryl, or aralkyl; and R3 represents —CH2OR5 (wherein R5 represents a carboxylic residue) and the like. The lubricating oil of the present invention has an excellent traction coefficient, excellent heat resistance, or the like. For the lubricating oil of the present invention, the alicyclic compound represented by the general formula (I) can be directly used as it is, and other base oils such as ester oil, poly-?-olefin, mineral oil, or silicone oil may be included therein, if necessary.Type: ApplicationFiled: September 13, 2006Publication date: June 18, 2009Applicant: KYOWA HAKKO CHEMICAL CO., LTD.Inventors: Suguru Ohara, Satoshi Hiyoshi, Yukihiro Isogai, Makoto Goto
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Publication number: 20090143611Abstract: The present invention relates to compounds of formula (I): wherein R1 is H, or a C1-C10 linear, branched or cyclic alkyl group which is unsubstituted or substituted with fluorine; R2 is an alicyclic group having 5 to 20 carbon atoms which is unsubstituted or substituted with fluorine; and R3 represents a C1-C10 linear or branched alkylene which is unsubstituted or substituted with fluorine. Processes for preparing such compounds are also disclosed. The compounds of the present invention can be used as monomers in the fields of photolithography and semiconductor fabrication.Type: ApplicationFiled: November 14, 2005Publication date: June 4, 2009Applicants: ST-JEAN PHOTOCHIMIE INC., INTERNATIONAL BUSINESS MACHINES CORPORATIONInventors: Shahrokh Motallebi, Denis Desilets, Ian Marcotte, Luc Bouchard, Khalil Feghali, Pushkara Rao Varanasi, Mahmoud Khojasteh
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Patent number: 7531685Abstract: The present application describes deuterium-enriched oxybutynin, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.Type: GrantFiled: June 1, 2007Date of Patent: May 12, 2009Assignee: Protia, LLCInventor: Anthony W. Czarnik
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Patent number: 7531686Abstract: The present invention provides a salt of the formula (I): wherein ring X represents polycyclic hydrocarbon group having tricycle or more and having 10 to 30 carbon atoms, and one or more hydrogen atom in the ring X is optionally substituted with alkyl group having 1 to 6 carbon atoms, alkoxy group having 1 to 6 carbon atoms, perfluoroalkyl group having 1 to 4 carbon atoms or cyano group; Q1 and Q2 each independently represent fluorine atom or perfluoroalkyl group having 1 to 6 carbon atoms; n shows an integer of 1 to 12; and A+ represents a cation selected from the group consist of a cation of the following formulae (IIa), (IIb) and (IIc): The present invention also provides a chemically amplified resist composition comprising the salt of the formula (I).Type: GrantFiled: October 26, 2006Date of Patent: May 12, 2009Assignee: Sumitomo Chemical Company, LimitedInventors: Yukako Harada, Isao Yoshida, Satoshi Yamaguchi
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Publication number: 20090076032Abstract: The present invention relates to novel derivatives of 18?-glycyrrhetinic acid and methods of synthesising the derivatives. Also included within the scope of the present invention are pharmaceutical compositions comprising the derivatives of the present invention and medical uses of the derivatives, including their use in inhibiting enzymes such as retinol dehydrogenases. The present invention also relates to methods of treating diseases, such as hyperproliferative diseases, neoplasms, cancers and photoageing.Type: ApplicationFiled: September 10, 2008Publication date: March 19, 2009Inventors: Simon Ward, Alice Macgowan, Stanley Roberts, Jenny Littlechild, Kirsty Line, Ed Irving, Sam Donnelly
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Patent number: 7501222Abstract: A polymer including a monomer represented by the following Formula and a photoresist composition including the same are disclosed. The polymer and photoresist composition can improve the resolution and the process margin due to the low activation energy of the deprotection reaction of the alcohol ester group including saturated cyclic hydrocarbyl group, and also can produce fine photoresist patterns because they have a stable PEB(Post Exposure Baking) temperature sensitivity, and further, can improve the focus depth margin and the line edge roughness of the resist layer. In the above Formula, R* is a hydrogen or methyl group, R1 is saturated hydrocarbyl group of 1 to 5 carbon atoms, R is mono-cyclic or multi-cyclic homo or hetero saturated hydrocarbyl group of 3 to 50 carbon atoms, and n is an integer of at least 2.Type: GrantFiled: June 21, 2006Date of Patent: March 10, 2009Assignee: Dongjin Semichem Co., Ltd.Inventors: Jung-Youl Lee, Jae-Woo Lee, Jae-Hyun Kim
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Patent number: 7494763Abstract: The present invention provides a polyhydric phenol compound represented by the formula (I): wherein at least one selected from R1, R2, R3, R4, and R5 is a group represented by the formula (II): wherein X1, X2, X3 and X4 each independently represent a hydrogen atom or a C1-C4 alkyl group, n represents an integer of 0 to 3, Z1 represents a C1-C6 alkyl group or a C3-C12 cycloalkyl group, and ring Y represents an alicyclic hydrocarbon group, and the others are hydrogen atoms, and a chemically amplified resist composition containing the same.Type: GrantFiled: October 22, 2007Date of Patent: February 24, 2009Assignee: Sumitomo Chemical Company, LimitedInventors: Ichiki Takemoto, Nobuo Ando, Junji Shigematsu
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Patent number: 7495122Abstract: A novel compound represented by a formula [1] wherein R1 and R2 respectively represent a light or heavy hydrogen atom, R3 represents a light or heavy hydrogen atom or a methyl group in which tree hydrogen atoms are respectively light or heavy hydrogen atoms, and R4 is a norbornyl group provided that four or more hydrogen atoms in the norbornyl group are heavy hydrogen atoms; and a novel polymer produced by polymerization of a composition comprising the compound are disclosed.Type: GrantFiled: July 23, 2004Date of Patent: February 24, 2009Assignees: Wako Pure Chemical Industries, Fujifilm CorporationInventors: Hiroki Sasaki, Tsuneaki Maesawa, Nobuhiro Ito, Kazushige Muto
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Publication number: 20090048204Abstract: A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9(11)-dien-28-oate (CDDO methyl ester), has a non-crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.Type: ApplicationFiled: August 13, 2008Publication date: February 19, 2009Inventors: John Walling, Stephan D. Parent, David T. Jonaitis, Robert M. Kral, JR.
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Patent number: 7488753Abstract: This invention provides composition comprising a triterpenoidal saponin, comprising two side groups attached to carbon 21, and 22 of triterpenoidal saponin backbone. This invention provides a composition for inhibiting skin or ovarian tumor cell growth, comprising an appropriate amount of said compound.Type: GrantFiled: November 28, 2005Date of Patent: February 10, 2009Assignee: Pacific Arrow LimitedInventors: Pui-Kwong Chan, May Sung Mak, Yun Wang
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Patent number: 7435848Abstract: A method for the continuous preparation of an alicyclic carboxylic acid or an ester of the alicyclic carboxylic acid. A plastic which incorporates the alicyclic carboxylic acid or an ester of the alicyclic carboxylic acid. An article made of a plastic which incorporates the alicyclic carboxylic acid or an ester of the alicyclic carboxylic acid. A liquid which incorporates the alicycic carboxylic acid or an ester of the alicyclic carboxylic acid.Type: GrantFiled: January 3, 2006Date of Patent: October 14, 2008Assignee: OXENO Olefinchemie GmbHInventors: Michael Grass, Burkhard Reeken, Axel Tuchlenski, Alfred Kaizik, Wilfried Büschken
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Patent number: 7419761Abstract: A photoresist polymer having a spiro cyclic ketal group, and a photoresist composition including the same is disclosed. The photoresist polymer and the photoresist composition can improve the resolution and the process margin due to its low activation energy of the deprotection reaction of the spiro cyclic ketal group, and can produce fine photoresist patterns due to its low PEB (Post Exposure Baking) temperature sensitivity.Type: GrantFiled: September 15, 2005Date of Patent: September 2, 2008Assignee: Dongjin Semichem Co., Ltd.Inventors: Jae-Woo Lee, Jung-Youl Lee, Deog-Bae Kim, Jae-Hyun Kim, Eun-Kyung Son
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Patent number: 7411085Abstract: A carbon nanotube dispersion includes a carbon nanotube compound represented by structural formula A and a dispersion medium in which the carbon nanotube is dispersed or dissolved, wherein a moiety represented by double lines represents a carbon nanotube R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group having one or two carbon atoms, a substituted or unsubstituted aryl group or a substituted or unsubstituted carbodiimide group, R2 represents a substituted or unsubstituted alkyl group having from 1 to 4 carbon atoms, and m and n each independently represents an integer of 1 or more.Type: GrantFiled: March 21, 2007Date of Patent: August 12, 2008Assignee: Fuji Xerox Co., Ltd.Inventors: Masaki Hirakata, Taishi Shigematsu
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Patent number: 7402712Abstract: Provided by the present invention are an adamantyl vinyl ether compound which is useful as a monomer for functional resins in the photolithography field or a raw material therefor and medical and agricultural intermediates and a production process for the same. The present invention relates to a production process for an adamantyl vinyl ether compound, characterized by subjecting an adamantyl vinyl ether compound having a specific structure and alcohol having an eliminating group in a ? position to chloroalkyl-etherification, then subjecting it to etherification to form an adamantyl group-containing ether and then subjecting it to vinyl-etherification.Type: GrantFiled: June 8, 2004Date of Patent: July 22, 2008Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Naoyoshi Hatakeyama, Shinji Tanaka, Hidetoshi Ono, Kouichi Kodoi
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Patent number: 7388070Abstract: A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.Type: GrantFiled: May 12, 2000Date of Patent: June 17, 2008Assignee: President and Fellows of Harvard CollegeInventors: Donald Coen, James Hogle, Carl Elkin, Harmon J. Zuccola, Kristie Grove Bridges, Scott Lokey
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Patent number: 7365221Abstract: Betulin and dihydrobetulin acyl derivatives according to the present invention have been found to have potent anti-HIV activity. The compounds of the present invention have Formula I as described herein, or pharmaceutically acceptable salts thereof; wherein R1 is a C2-C20 substituted or unsubstituted carboxyacyl or ester thereof; R2 is hydrogen, halogen, hydroxyl or —OR3, R3 is C2-C20 substituted or unsubstituted carboxyacyl; and R4 is hydrogen or C(C6H5)3; wherein the dashed line represents an optional double bond between C20 and C29.Type: GrantFiled: June 18, 2004Date of Patent: April 29, 2008Assignees: Panacos Pharmaceuticals, Inc., The University of North Carolina at Chapel Hill, Niigata University of Pharmacy and Applied Life SciencesInventors: Graham P. Allaway, Carl T. Wild, Yoshiki Kashiwada, Kuo-Hsiung Lee
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Patent number: 7288671Abstract: Novel compounds are disclosed that have the following chemical structures, and prodrug esters and acid-addition salts thereof, that are useful as Interleukin-1 and Tumor Necrosis Factor-? modulators, and thus are useful in the treatment of various diseases. wherein the R groups are defined as follows: if any R3-R5, R7, R8, R11-R13 is not hydrogen, R2 or R6 or R9 is not methyl, or R10 is not CH2, then R1 is selected from the group consisting of hydrogen, a halogen, COOH, C1-C12 carboxylic acids, C1-C12 acyl halides, C1-C12 acyl residues, C1-C12 esters, C1-C12 secondary amides, (C1-C12)(C1-C12) tertiary amides, (C1-C12)(C1-C12) cyclic amides, (C1-C12) amines, C1-C12 alcohols, (C1-C12)(C1-C12) ethers, C1-C12 alkyls, C1-C12 substituted alkyls, C2-C12 alkenyls, C2-C12 substituted alkenyls, and C5-C12 aryls.Type: GrantFiled: May 3, 2006Date of Patent: October 30, 2007Assignees: Nereus Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Michael Palladino, Emmanuel A. Theodorakis
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Patent number: 7253300Abstract: In a process for producing tricyclo[5.2.1.02,6]decane-2-carboxylic acid ester by reacting tricyclo[5.2.1.02,6]deca-3-ene with carbon monoxide and alcohol in the presence of HF, carried out separately are (a) a step in which tricyclo[5.2.1.02,6]deca-3-ene is reacted with carbon monoxide to produce acyl fluoride and (b) a step in which acyl fluoride obtained in the step described above is reacted with alcohol to produce an ester. Also, the reaction conditions at the step (a) described above are selected or a step for carrying out isomerization reaction of tricyclo[5.2.1.02,6]decane-2-carboxylic fluoride obtained at the step (a) is interposed between the step (a) and the step (b). Further, the crude product of tricyclo[5.2.1.02,6]decane-2-carboxylic acid ester thus obtained is subjected to contact treatment with specific glycol in the presence of an acid catalyst and then distilled.Type: GrantFiled: September 17, 2004Date of Patent: August 7, 2007Assignees: Mitsubishi Gas Chemical Company, Inc., Kao CorporationInventors: Mitsuharu Kitamura, Takashi Kojima, Yoshiharu Ataka, Tomoaki Kubota, Kinji Kato, Kazuyuki Fukuda
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Patent number: 7223882Abstract: A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 are each independently C1–C8 alkyl.Type: GrantFiled: March 18, 2003Date of Patent: May 29, 2007Assignee: Shionogi & Co., Ltd.Inventors: Haruo Koike, Katsuo Oda, Yutaka Nishino, Makoto Kakinuma
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Patent number: 7144939Abstract: The use of organic based nucleating agents to induce certain specific polymer orientations into the molded polypropylene articles such that the resultant part has improved stiffness-impact properties without sacrificing other attributes of the polypropylene is provided. Such results have been obtained through the utilization of low amount of organic nucleating compounds, including, without limitation, specific metal salts of hexahydrophthalic acid (hereinafter HHPA). Furthermore, such nucleating compounds have been found to impart, again in such low added amounts, heretofore unforeseen levels of b-axis crystalline orientation which translates into improved physical properties as well.Type: GrantFiled: July 29, 2003Date of Patent: December 5, 2006Assignee: Milliken & CompanyInventors: Darin L. Dotson, Brian M. Burkhart
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Patent number: 7119223Abstract: Novel compounds are disclosed that have the following chemical structures, and prodrug esters and acid-addition salts thereof, that are useful as Interleukin-1 and Tumor Necrosis Factor-? modulators, and thus are useful in the treatment of various diseases. wherein the R groups are defined as follows: if any R3–R5, R7, R8, R11–R13 is not hydrogen, R2 or R6 or R9 is not methyl, or R10 is not CH2, then R1 is selected from the group consisting of hydrogen, a halogen, COOH, C1–C12 carboxylic acids, C1–C12 acyl halides, C1–C12 acyl residues, C1–C12 esters, C1–C12 secondary amides, (C1–C12)(C1–C12) tertiary amides, (C1–C12)(C1–C12) cyclic amides, (C1–C12) amines, C1–C12 alcohols, (C1–C12)(C1–C12) ethers, C1–C12 alkyls, C1–C12 substituted alkyls, C2–C12 alkenyls, C2–C12 substituted alkenyls, and C5–C12 aryls.Type: GrantFiled: March 27, 2002Date of Patent: October 10, 2006Assignees: Nereus Pharmaceuticals, Inc., The Regents of the University of CaliforniaInventors: Michael Palladino, Emmanuel A. Theodorakis
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Patent number: 7019149Abstract: A method of treating ocular hypotension, hypertension, hemorrhage, myocardial ischemia, angina pectoris, coronary contraction, cerebrovascular contraction after subarachnoidal hemorrhage, cerebral hemorrhage and asthma which comprises administering to a mammal suffering therefrom a therapeutically effective amount of a thromboxane ligand which is a compound formula I, wherein Y is (CH2)x; Z is selected from the group consisting of and (CR2)x, x is an integer of 1 or 2; n is 0 or 1; R2 is hydrogen or an alkyl radical of from 1 to 4 carbons; A is an alkylene or alkenylene radical having from two to seven carbon atoms, which radical may be substituted with one or more hydroxy, oxo, alkyloxy or alkylcarboxy groups or said alkylene or alkenylene may have one or more enchained oxa or imino radicals; B is a methyl radical or a cycloalkyl radical having from three to seven carbon atoms, or an aryl radical, selected from the group consisting of hydrocarbyl aryl and heteroaryl radicals wherein the heteroatom isType: GrantFiled: September 17, 2004Date of Patent: March 28, 2006Assignee: Allergan, Inc.Inventors: Robert M. Burk, Achim H-P Krauss, David F. Woodward
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Patent number: 6930128Abstract: The application discloses methods of treating mammalian diseases characterized by abnormal cell mitosis by administering estradiol derivatives including those comprising colchicine or combretastatin A-4 structural motifs of the general formulae found below in a dosage sufficient to inhibit cell mitosis. The application discloses novel compounds used in the methods.Type: GrantFiled: July 10, 2003Date of Patent: August 16, 2005Assignee: The Children's Medical Center CorporationInventors: Robert John D'Amato, Moses Judah Folkman
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Patent number: 6881857Abstract: Disclosed herein are novel tricyclic diterpene compounds. These compounds, including their prodrug esters and acid-addition salts, are useful as Interleukin-1 and Tumor Necrosis Factor-? modulators, and thus are useful in the treatment of various diseases. Also disclosed are pharmaceutical compositions comprising a therapeutically effective amount of the novel compounds that are useful as anti-inflammatory analgesics, in treating immune disorders, as anti-cancer and anti-tumor agents, and in the treatment of cardiovascular disease, skin redness, and viral infection. Completely synthetic and semi-synthetic methods of making the compounds and their analogs are also disclosed, as are methods of using these synthetic and semi-synthetic compounds in the treatment of the above-listed disease states.Type: GrantFiled: February 4, 2002Date of Patent: April 19, 2005Assignees: Nereus Pharmaceuticals, Inc., University of CaliforniaInventors: Michael Palladino, Emmanuel A. Theodorakis
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Patent number: 6872846Abstract: The production process of the present invention comprises a step of allowing a carboxylic acid derivative represented by the formula (1): wherein ring Z is a monocyclic or polycyclic non-aromatic or aromatic ring, and R1 is a halogen atom or a group represented by the formula (2): —OR??(2) wherein R is a hydrogen atom or a hydrocarbon group, to react with an organometallic compound represented by the formula (3): R2-M??(3) wherein R2 is a hydrocarbon group, and M is a metallic atom which may have a ligand, or the formula (4): -MgY??(4) wherein Y is a halogen atom, and a carboxylic acid halide represented by the formula (5): wherein R3 is a hydrocarbon group or a heterocyclic group, and X is a halogen atom, to yield the tertiary alcohol ester represented by the formula (6): wherein Z, R2 and R3 have the same meanings as defined above.Type: GrantFiled: November 13, 2001Date of Patent: March 29, 2005Assignee: Daicel Chemical Industries, Ltd.Inventors: Shinya Nagano, Hiroshi Shimojitosho
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Patent number: 6864278Abstract: Sordarin derivatives prepared from C-11-hydroxysordarin are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.Type: GrantFiled: July 12, 2002Date of Patent: March 8, 2005Assignee: Merck & Co., Inc.Inventors: James M. Balkovec, Bruno Tse
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Patent number: 6852885Abstract: There is provided a method for obtaining a target organic compound such as an alkyladamantyl ester efficiently by purifying a crude organic compound which contains, as impurities, sublimable materials which start to sublime at temperatures lower than a boiling point of the target organic compound by use of such a simple method as distillation during its production process, without being adversely affected by adherence of the sublimable materials. The distillation is carried out in the presence of a compound having a boiling point which is lower than a boiling point of the target organic compound, e.g., a carbonyl-group-containing compound. For example, 2-methyl-2-adamantyl methacrylate (boiling point: 92° C./0.3 mmHg) containing sublimable impurities such as adamantane (sublimation starting temperature: room temperature or lower) is distilled in the presence of 1,3-dimethyl-2-imidazolidinone (boiling point: 225° C.).Type: GrantFiled: January 26, 2001Date of Patent: February 8, 2005Assignee: Tokuyama CorporationInventors: Hiromasa Yamamoto, Masao Yamaguchi, Hideki Kikuchi
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Patent number: 6833388Abstract: There is provided a trisadamantane based compound which is useful not only as a photoresist additive but also as pharmaceuticals, an agrochemical intermediate, a resin additive (heat resistance improver) and the like, and which is represented by the general formula (I): wherein R1 and R2 are each an alkyl group having 1 to 8 carbon atoms; X1 and X2 are each hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, hydroxyl group, an alkoxy group having 1 to 8 carbon atoms, carboxyl group or COOR3 in which R3 is an alkyl group having 1 to 8 carbon atoms.Type: GrantFiled: December 17, 2003Date of Patent: December 21, 2004Assignee: Idemitsu Petrochemical Co., Ltd.Inventors: Shinji Tanaka, Toshihide Yoshitome, Takashi Nakagawa, Kouichi Kodoi