Plural Rings In Phenolic Moiety Patents (Class 560/138)
  • Patent number: 4633012
    Abstract: A liquid crystal compound represented by the following general formula: ##STR1## wherein m is a number from 0 to 10, n is a number from 5 to 14, and C having an asterisk indicates an asymmetric carbon atom.
    Type: Grant
    Filed: June 10, 1985
    Date of Patent: December 30, 1986
    Assignees: Seiko Instruments & Electronics Ltd., Teikoku Chemical Industry Co., Ltd.
    Inventors: Masaaki Taguchi, Takamasa Harada, Hitoshi Suenaga
  • Patent number: 4622163
    Abstract: New anisotropic compounds with a cross-polarizing substituent have the formula (1) ##STR1## The increase in .epsilon..perp. is achieved by the polarizing group X, preferably the cyano group or a halogen atom, which is not laterally on the ring, as with the known compounds, but is on the bridge, that is to say is part of the main bridge bonding rings A and B to one another. Ring A has the formula (1a) or (1b) given herein and is always cycloaliphatic, while ring B can be identical to ring A or is an aromatic ring of the formula (1c) or (1d) herein. R.sup.1 and R.sup.2 are identical or different end groups of the formula (1e) herein. The radical X on the bridge causes less widening of the molecule than a radical X on a ring, which provides comparatively higher clear points and moreover enables aromatic rings to be omitted from the anisotropic compounds.
    Type: Grant
    Filed: September 10, 1984
    Date of Patent: November 11, 1986
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Tuong Huynh-Ba, Maged A. Osman
  • Patent number: 4606845
    Abstract: New bicyclohexylethanes of formula IR.sup.1 --Cy--Cy--CH.sub.2 CH.sub.2 --A--(Cy).sub.n --R.sup.2 (I)wherein R.sup.1 is alkyl; R.sup.2 is alkyl, in which one or two non-adjacent CH.sub.2 groups can be replaced by O atoms, or is F, Cl, Br, CN, --COOalkyl or --O--CO-alkyl; or one of the radicals R.sup.1 and R.sup.2 can also be H; A is Cy, or 1,4-phenylene which is unsubstituted or substituted by one or two F and/or Cl atoms and/or CH.sub.3 groups or by a CN group; Cy is 1,4-cyclohexylene and n is 0 or 1; the alkyl groups in each case containing 1-10 C atoms, with the proviso that n is 1 if A is Cy and R.sup.2 is CN,can be used as constituents of dielectrics for electrooptical display elements.
    Type: Grant
    Filed: May 14, 1984
    Date of Patent: August 19, 1986
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Michael Romer, Rudolf Eidenschink, Joachim Krause, Bernhard Scheuble, Georg Weber
  • Patent number: 4596828
    Abstract: [(2-Hydroxy-5-alkoxyphenyl)methylthio]phenylmethanol and derivatives thereof were prepared from an appropriate 2-hydroxy-5-alkoxybenzaldehyde with a hydroxymethylthiophenol. These compounds were found to be potent anti-inflammatory agents.
    Type: Grant
    Filed: March 28, 1985
    Date of Patent: June 24, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Milton L. Hammond, Robert A. Zambias
  • Patent number: 4587262
    Abstract: The invention concerns novel glyceride esters of anti-bacterial halogenated phenols having the formula I in which Ra and Rb are independently (3-20C)alkyl or (3-20C)alkenyl; Rc and Rd are independently chloro or bromo; Re is hydrogen, chloro or bromo; and A is (1-6C)alkylene optionally bearing one or two (1-4C)alkyl substituents.The esters are of use in the prophylaxis and/or therapy of acne vulgaris. Pharmaceutical compositions for topical administration and processes for the manufacture of the esters are also provided.
    Type: Grant
    Filed: June 6, 1983
    Date of Patent: May 6, 1986
    Assignee: Imperial Chemical Industries PLC
    Inventors: Jean C. Arnould, John R. Evans, Geraint Jones, David S. Thomson
  • Patent number: 4584190
    Abstract: A chalcone derivative of the formula (I): ##STR1## in which R.sub.1 represents hydrogen or a methyl group, and R.sub.2 represents a linear or branched aliphatic hydrocarbon group having from 2 to 24 carbon atoms.The derivative is effective in protecting the skin when made into ultraviolet absorbing agents including an anti-sunburn oil, since it has the maximum absorbing capacity at a wave length in the vicinity of 350 nm, does not irritate the skin and is highly compatible with a cosmetic base.
    Type: Grant
    Filed: November 9, 1984
    Date of Patent: April 22, 1986
    Assignee: Kao Corporation
    Inventors: Tohru Tejima, Koichi Nakamura, Michihiro Hattori, Shinichi Masuda, Genji Imokawa, Naotake Takaishi
  • Patent number: 4584318
    Abstract: A method is described for the control of nematodes in agricultural crops which comprises applying to the situs of infestation of a nematicidal composition containing as active ingredient a compound of the formula ##STR1## wherein Q is hydroxy, carbamoyloxy, or acyloxy, R is alkyl, alkenyl, alkynyl, X is halogen or methyl, n is 1 or 2. Preparation of active ingredient compounds is described, and nematicidal utility of compositions is exemplified.
    Type: Grant
    Filed: June 20, 1983
    Date of Patent: April 22, 1986
    Assignee: FMC Corporation
    Inventors: Clinton J. Peake, Carmine P. DiSanzo, John F. Engel
  • Patent number: 4565888
    Abstract: Anthelmintically active novel substituted salicylic acid amides of the formula ##STR1## in which X and Y each independently is halogen, and,R.sup.1 is hydrogen or acetyl.
    Type: Grant
    Filed: January 11, 1985
    Date of Patent: January 21, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Peter Andrews, Horst Boshagen, Heinrich Kolling
  • Patent number: 4564628
    Abstract: Novel compounds useful as dopamine receptor agonists for the treatment of various diseases of the central nervous system such as Parkinson's disease and related disorders having the structural formula ##STR1## where R.sub.2, R.sub.3 and R.sub.4 are each selected from the group consisting of H, and OA; A is H or ##STR2## R.sub.5 is selected from the group consisting of alkyl and aromatic residues; n is 2 or 3; and R.sub.1 is selected from the group consisting of 3-hydroxyphenyl, 4-hydroxyphenyl, 3-pyridyl, 4-pyridyl, ##STR3## where X is S, O or NH; and pharmaceutically acceptable salts thereof. Also disclosed is a method for inducing a dopaminergic response in a patient by adminstering a pharmacologically-effective amount of one of the foregoing compounds.
    Type: Grant
    Filed: August 13, 1984
    Date of Patent: January 14, 1986
    Assignee: Nelson Research & Development Co.
    Inventor: Alan S. Horn
  • Patent number: 4556745
    Abstract: A liquid crystal composition includes at least one compound of Formula (I) as follows:A--CH.sub.2.CH.sub.2 --B Formula (I)where A and B are substituted ring structures which include terminal alkyl groups, A being selected from: ##STR1## where R'.sub.1 is an alkyl group R.sub.1, an alkoxy group R.sub.1 O, an alkylcarbonyloxy group R.sub.1 CO.O or an alkoxycarbonyloxy group R.sub.1 OCO.O; ##STR2## where R.sub.1 is an alkyl group; or ##STR3## where R.sub.1 is an alkyl group; and B being selected from: ##STR4## where R'.sub.2 is an alkyl group R.sub.2, an alkoxy group OR.sub.2, an alkylcarbonyloxy group OCO.R.sub.2 or an alkoxycarbonyloxy group OCO.OR'.sub.2 ; and X is hydrogen or a cyano group or a methyl group or a halogen; ##STR5## where R.sub.2 is an alkyl group; or ##STR6## where R.sub.2 is an alkyl group; ##STR7## being a trans-1,4-disubstituted cyclohexane ring and ##STR8## a 1,4-disubstituted bicyclo(2,2,2)octane ring.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: December 3, 1985
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Neil Carr, George W. Gray
  • Patent number: 4542159
    Abstract: There are prepared compounds of the formula: ##STR1## wherein X is the group >C.dbd.O or >CH(OH), Y is the group ##STR2## R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl, R.sub.3 is hydrogen or a hydroxy group and R.sub.1 is the adamantyl group or a saturated or single unsaturated C.sub.3 to C.sub.16 cycloalkyl group where the C.sub.3 to C.sub.16 cycloalkyl group can be substituted by a C.sub.1 -C.sub.4 alkyl group or a halogen atom and their salts. The compounds are useful in dilating the peripheral blood vessels and in lowering blood pressure.
    Type: Grant
    Filed: May 15, 1979
    Date of Patent: September 17, 1985
    Assignee: Degussa Akteinsellschaft
    Inventors: Jurgen Engel, Axel Kleemann, Klaus Posselt, Fritz Stroman, Klaus Thiemer
  • Patent number: 4540811
    Abstract: A carboxylic acid esters, such as methyl propionate, is prepared by carbonylation of an olefin, such as ethylene, in the presence of an alcohol by the use of a molybdenum-nickel-alkali metal, a tungsten-nickel-alkali metal or a chromium nickel-alkali metal co-catalyst and in the presence of a halide.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: September 10, 1985
    Assignee: The Halcon SD Group, Inc.
    Inventor: Nabil Rizkalla
  • Patent number: 4519936
    Abstract: The invention relates to nematic liquid crystals in electro-optical components for the modulation of light as well as for the representation of numerals, signs and images and to a method for producing the same.It is the object of the invention to create nematic liquid crystals which are well suited for electro-optical devices, preferably for two-frequency operation.It has been found that pure or mixed 2-n-alkyl-1, 4-bis-[4-acyloxy]-benzenes of the general formula ##STR1## wherein R.sup.3 =n-C.sub.m H.sub.2m+1, with m=3 to 14, are well suited for utilization in electro-optical components.It was found that 2-n-alkyl-1,4-bis-[acyloxy]-benzene which is well suited for electro-optical components, and especially for two-frequency operations, can be produced by the conversion of a correspondingly substituted benzoic acid or cyclohexane carboxylic acid or a reaction-capable derivative thereof with the corresponding 2-n-alkylhydroquinone--also in the form of its phenylate--at a temperature ranging from 0.degree. C.
    Type: Grant
    Filed: July 20, 1982
    Date of Patent: May 28, 1985
    Assignee: VEB Werk fuer Fernsehelektronik im Kombinat Mikroelektronik
    Inventors: Dietrich Demus, Wolfgang Weissflog, Horst Kresse
  • Patent number: 4505837
    Abstract: A phenylcyclohexene of the formula ##STR1## wherein n is 1 or 2, X is --H, --R, --OR, --OCOR, --OCOOR, --CF.sub.3 or --F, and when n is 1, X can also be ##STR2## R is alkyl of 1-8 C atoms and when two R groups are present they can be the same or different, has valuable liquid crystalline properties.
    Type: Grant
    Filed: March 24, 1983
    Date of Patent: March 19, 1985
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Michael Romer, Ludwig Pohl, Rudolf Eidenschink
  • Patent number: 4503256
    Abstract: Novel compounds of general formula I ##STR1## wherein R is a branched or unbranched alkyl, cycloalkyl, or aralkyl group, which group optionally contains or is substituted by a halogen or oxygen function, the oxygen function optionally being in the form of an alcohol or ether moiety;R.sub.1, R.sub.2, and R.sub.3, which may be the same or different, is hydrogen, an alkyl, acyl, or benzoyl group, which group optionally contains or is substituted by a halogen or oxygen function;R.sub.4 is hydrogen, an alkyl, alkenyl preferably being an allyl or prenyl group, or aralkyl group which group optionally contains or is substituted by an alkyl, aryl, halogen or oxygen function;R.sub.5 is hydrogen, an alkyl, aralkyl, acyl, or aryl group, which group optionally contains or is substituted by an alkyl, aryl, halogen, or oxygen function;except that R.sub.4 and R.sub.5 are not both hydrogen;and except for the compounds when R.sub.
    Type: Grant
    Filed: June 21, 1982
    Date of Patent: March 5, 1985
    Assignee: Noristan Limited
    Inventors: Theunis G. Fourie, Theodor G. Dekker, Friedrich O. Snyckers, Cornelis J. van der Schyf
  • Patent number: 4495104
    Abstract: A compound of the general formula ##STR1## wherein n is an integer of 10 to 21, inclusive; R is H or lower alkyl having 1 to 4 carbon atoms has pharmaceutical activities such as hypotensive, tissue metabolism stimulating, immuno-regulatory, lysosomal membrane stabilizing and SRS-A production inhibitory activities and is useful as a heart failure remedy, cerebral circulation disturbance remedy, immuno-regulator, and antiallergic drug.
    Type: Grant
    Filed: July 11, 1980
    Date of Patent: January 22, 1985
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Isuke Imada, Tetsuya Okutani, Masazumi Watanabe
  • Patent number: 4490552
    Abstract: A novel process for the preparation of aryl esters of organic carboxylic acids in high isomer purity by decomposing a compound of the formula ##STR1## wherein Ar is an aryl radical, X is an acyloxy of an organic carboxylic acid and Y is selected from the group consisting of an acyloxy of an organic carboxylic acid and an anion of a strong organic and mineral acid in an aqueous media in the presence of a palladium salt or in the form of a two-phase reaction, wherein the aryl thallium salt is dissolved in water and the catalytic palladium salt is dissolved in a water-immiscible organic solvent and the reaction takes place with mixing.
    Type: Grant
    Filed: December 20, 1982
    Date of Patent: December 25, 1984
    Assignee: Rutgerswerke AG
    Inventor: Ulrich Knips
  • Patent number: 4478741
    Abstract: A liquid crystal composition contains a compound of the formula: ##STR1## wherein R and R' are straight chain alkyl groups each having 1 to 7 carbon atoms.
    Type: Grant
    Filed: April 29, 1983
    Date of Patent: October 23, 1984
    Assignee: Sharp Kabushiki Kaisha
    Inventors: Kenichi Nakagawa, Shigehiro Minezaki, Fumiaki Funada
  • Patent number: 4477556
    Abstract: A photopolymerizable coating composition comprising(1) a nongaseous, ethylenically unsaturated, polymerizable compound,(2) a specified acidic o-nitroaromatic compound, and(3) an organic, radiation-sensitive, free-radical generating system which is useful for making a positive or negative polymeric image on a substrate.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: October 16, 1984
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Thomas E. Dueber, William J. Nebe
  • Patent number: 4470997
    Abstract: The invention concerns di- and tri-esters derived from alkanoic, (cycloalkyl)alkanoic, benzoic or phenylalkanoic acids with N-(acylaminoalkyl)-dihydroxyphenylethanolamines, and pharmaceutically acceptable salts thereof; processes for their preparation and manufacture; and pharmaceutical compositions thereof. The esters are useful for the topical treatment of an area of inflammation affecting the skin of a warm-blooded animal. Representative esters of the invention are 1-[3,4-bis(pivaloyloxy)phenyl]-2-[2-(2-phenylacetamido)ethylamino]-ethanol , 1-[3,4-bis(pivaloyloxy)phenyl]-2-[1,1-dimethyl-2-(2-phenoxyacetamido)ethy lamino]-ethanol, and the hydrochlorides and hydrobromides thereof.
    Type: Grant
    Filed: September 9, 1982
    Date of Patent: September 11, 1984
    Assignee: Imperial Chemical Industries PLC
    Inventors: Geraint Jones, John Preston, David S. Thomson
  • Patent number: 4468524
    Abstract: This invention pertains to an acrylate or methacyrate of monohydric or dihydric, mononuclear or binuclear phenols which are substituted by allyl, methallyl or 1-propenyl groups, or hydroxyalkyl ethers thereof.The acrylates or methacrylates of the invention can be used in compositions useful in a casting or impregnating resin, adhesive, lacquer and binder which can be cured by irradiation and/or heat.
    Type: Grant
    Filed: September 16, 1982
    Date of Patent: August 28, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Sheik A. Zahir, Sameer H. Eldin
  • Patent number: 4439015
    Abstract: Disubstituted ethanes of the formula ##STR1## wherein R.sup.2 is --R.sup.3, --OR.sup.3, --CO--R.sup.3, --CO--OR.sup.3 or O--CO--R.sup.3, R.sup.1 and R.sup.3 each are straight-chain alkyl of 1 to 12 carbon atoms and n is 1 or 2,are described. Liquid crystalline mixtures comprising Compound I as well as their use in electro-optical devices also are disclosed.
    Type: Grant
    Filed: January 22, 1982
    Date of Patent: March 27, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Roland Rich, Alois Villiger, Erich Widmer
  • Patent number: 4435394
    Abstract: 3-Sulfonamido-benzophenonimine derivatives useful for prophylactically or therapeutically treating patients suffering from viral infections are provided from 3-sulfonamido-benzophenones.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: March 6, 1984
    Assignee: Shionogi & Co., Ltd.
    Inventors: Masaru Ogata, Kosaburo Sato
  • Patent number: 4427697
    Abstract: The present invention provides 1,2-diphenylethane derivatives of the general formula: ##STR1## wherein X is a hydrogen or halogen atom, R and R', which may be the same or different, are alkyl radicals optionally substituted by halogen atoms, R.sub.1 and R.sub.2, which may be the same or different, are acyl radicals, hydroxyl groups or acylated hydroxyl groups and R.sub.3 and R.sub.4, which may be the same or different, are hydroxyl groups or acylated or alkylated hydroxyl groups.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: January 24, 1984
    Assignee: Biorex Laboratories Limited
    Inventor: Rosalind P. K. Chan
  • Patent number: 4423070
    Abstract: The invention concerns di- and tri-esters derived from alkanoic, (cycloalkyl)alkanoic, benzoic or phenylalkanoic acids with N-(acylaminoalkyl)-dihydroxyphenylethanolamines, and pharmaceutically acceptable salts thereof; processes for their preparation and manufacture; and pharmaceutical compositions thereof. The esters are useful for the topical treatment of an area of inflammation affecting the skin of a warm-blooded animal. Representative esters of the invention are 1-[3,4-bis(pivaloyloxy)phenyl]-2-[2-(2-phenylacetamido)ethylamino]-ethanol , 1-[3,4-bis(pivaloyloxy)phenyl]-2-[1,1-dimethyl-2-(2-phenoxyacetamido)-eth ylamino]-ethanol, and the hydrochlorides and hydrobromides thereof.
    Type: Grant
    Filed: November 23, 1977
    Date of Patent: December 27, 1983
    Assignee: Imperial Chemical Industries Limited
    Inventors: Geraint Jones, John Preston, David S. Thomson
  • Patent number: 4421763
    Abstract: Derivatives of 2-substituted-cyclohexane-1,3-diones possessing antihypertensive activity.
    Type: Grant
    Filed: March 26, 1982
    Date of Patent: December 20, 1983
    Assignee: Eisai Co., Ltd.
    Inventors: Sachiyuki Hamano, Shinichi Kitamura, Toshiji Igarashi, Yoshikage Nakajima
  • Patent number: 4399075
    Abstract: Phenoxytoluene derivative is chlorinated in a very high yield and selectivity in the presence of nitrogen-, sulfur-, phosphorus- or oxygen-containing compound which is capable of forming a charge-transfer complex with chlorine, chlorine radical or organic halogen compound, together with radical initiator and organic halogen compound.
    Type: Grant
    Filed: June 25, 1981
    Date of Patent: August 16, 1983
    Assignee: Asahi Chemical Company, Limited
    Inventors: Zenichi Yoshida, Susumu Kato, Takuya Fujiki, Yasuhiro Amemiya
  • Patent number: 4385067
    Abstract: A broad spectrum fungicide having the formula: ##STR1## wherein Y is acrylate, methacrylate, hydroxy, methoxy, halo, or a halogenated methyl group; k has a value of 0 or 1; m has a value of from 0 to 2, and R and R' are each independently hydrogen or methyl and mixtures of said acrylates as well as the method of their application to plants for the control of fungi infestation.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: May 24, 1983
    Assignee: GAF Corporation
    Inventor: Bruce M. Resnick
  • Patent number: 4358308
    Abstract: The 4-perfluoroacetyl-, 4-perfluoromethylthio-, 4-perfluoromethylsulfinyl-, and 4-perfluoromethylsulfonyl-4'-nitrodiphenyl ethers comprise a class of compounds that are highly effective herbicides.
    Type: Grant
    Filed: October 19, 1981
    Date of Patent: November 9, 1982
    Assignee: Rohm and Haas Company
    Inventor: Colin Swithenbank
  • Patent number: 4357078
    Abstract: Novel liquid crystal compounds exhibiting a low dielectric anisotropy have a structural formula: ##STR1## where R.sub.1 is an alkyl group, R.sub.2 is a group containing an alkyl group R and is either an alkyl group R, an alkoxy group OR, an alkylcarbonyloxy group OCOR or an alkoxycarbonyloxy group OCOOR, R.sub.1 and R containing up to 18 carbon atoms, ##STR2## is a trans-1,4-disubstituted cyclohexane ring ##STR3## or a 1,4-disubstituted bicyclo(2,2,2)octane ring ##STR4## and Ar is a 1,4 disubstituted benzene ring ##STR5## a 3-fluoro-1,4 disubstituted benzene ring ##STR6## or a 2,6 disubstituted naphthalene ring ##STR7## These compounds may be used in liquid crystal mixture compositions for use in a number of known electro-optic effects.The compounds may be prepared by routes in which the individual steps involved are known.
    Type: Grant
    Filed: January 27, 1981
    Date of Patent: November 2, 1982
    Assignee: The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Northern Ireland
    Inventors: Neil Carr, George W. Gray, Stephen M. Kelly
  • Patent number: 4349471
    Abstract: A process for the simultaneous preparation of an aromatic sulphonic acid halide and an aromatic carboxylic acid halide or the corresponding carboxylic acid is disclosed wherein an aromatic sulphonic acid or acid anhydride is reacted with an aromatic trihalogenomethyl compound in the presence of a Bronsted acid or Lewis acid at a temperature of 20.degree. to 300.degree. C., if appropriate in the presence of a solvent. Generally, at least half an equivalent of aromatic trihalogenomethyl compound is employed per equivalent of sulphonic acid.
    Type: Grant
    Filed: January 22, 1981
    Date of Patent: September 14, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz U. Blank, Erich Wolters, Norbert Langenfeld
  • Patent number: 4343796
    Abstract: The invention relates to compounds of the formula: ##STR1## in which R.sub.1 and R.sub.2 are the same or different groups selected from hydrogen or acyl orR.sub.1 and R.sub.2 together may represent an acetal group, andX and Y are the same or different groups selected from hydroxy, an etherified hydroxy and an esterified hydroxy group,having valuable lipid lowering, anti-inflammatory and immuno-modulating properties.
    Type: Grant
    Filed: June 11, 1981
    Date of Patent: August 10, 1982
    Assignee: AKZO NV
    Inventor: Marinus B. Groen
  • Patent number: 4340603
    Abstract: Novel, transient inotropic prodrug forms of the N-(2-phenylethyl)-.omega.-phenylalkylamines, notably of dobutamine, have (i) the structural formula (I): ##STR1## with the proviso that at least one R.sup.1, R.sup.2 or OR.sup.1, when R.sup.7 and/or R.sup.10 is OR.sup.1, must be R.sup.3 COXCH(R.sup.4)-- or R.sup.3 COXCH(R.sup.4)O--, respectively.
    Type: Grant
    Filed: August 13, 1980
    Date of Patent: July 20, 1982
    Assignee: INTERx Research Corporation
    Inventors: Nicholas S. Bodor, Kenneth B. Sloan, Stefano A. Pogany
  • Patent number: 4335254
    Abstract: Disclosed herein are monomeric compounds having the formula: ##STR1## wherein: R and R.sup.1 are independently hydrogen, halide or alkyl;R.sup.2 and R.sup.3 are independently hydrogen, alkyl, cycloalkyl, aryl or aralkyl;q is 0 or 1; andAr is arylene wherein no more than one of R.sup.2 and R.sup.3 is hydrogen, and a method of preparing same.These monomers can be homopolymerized or coplymerized with one or more other monomers to yield polymers having desirable solubility characteristics. In particular, copolymerizable ethylenically unsaturated monomers can comprise aldehyde-containing vinylaryl ethers to yield crosslinkable polymers useful in relief image materials or as binders in photographic layers.
    Type: Grant
    Filed: May 29, 1981
    Date of Patent: June 15, 1982
    Assignee: Eastman Kodak Company
    Inventors: John C. Wilson, Paul D. Yacobucci
  • Patent number: 4335055
    Abstract: Compounds of the formula I ##STR1## in which Z, Z.sub.1, R, m and p are as defined in patent claim 1, can be obtained in a simple and economical manner by a novel process wherein a halide of the formula II ##STR2## is reacted with a substituted or unsubstituted vinylbenzene or vinylnaphthalene derivative in the presence of a base and of certain palladium catalysts, such as palladium acetate. The compounds (I) or functional derivatives preparable therefrom are useful, for example, for the preparation of known dyes or fluorescent brighteners, or can be used directly as fluorescent brighteners or as scintillators.
    Type: Grant
    Filed: May 8, 1981
    Date of Patent: June 15, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans-Ulrich Blaser, Dieter Reinehr, Alwyn Spencer
  • Patent number: 4324800
    Abstract: A compound of the formula: ##STR1## wherein R is alkanoyl of one to 20 carbon atoms, benzoyl or lower alkyl-benzoyl, and processes for preparation thereof are disclosed. Said compound (I) and a pharmaceutically acceptable acid addition salt thereof are useful as a cardiotonic agent.
    Type: Grant
    Filed: March 12, 1981
    Date of Patent: April 13, 1982
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Norihide Umino, Tokuro Ohishi, Muneyoshi Ikezaki, Masanori Sato, Taku Nagao
  • Patent number: 4320144
    Abstract: The alkylene diphenyl ester compounds having the formula ##STR1## wherein halo is fluorine, chlorine or bromine; R is a radical having not more than 4 carbon atoms, selected from the group consisting of alkenyl, haloalkenyl and haloalkyl; R.sup.1 and R.sup.2 are each independently hydrogen or methyl; X is hydroxy or the radical RCOO--; m has a value of from 0 to 2; n has a value of from 0 to 6; w and p have values of 0 or 1, except that w is 1 when n is zero; the application of said compounds to plant in amounts sufficient to control fungi infestation and application of mixtures of said compounds to plants.
    Type: Grant
    Filed: April 3, 1981
    Date of Patent: March 16, 1982
    Assignee: GAF Corporation
    Inventor: Bruce M. Resnick
  • Patent number: 4315026
    Abstract: A novel class of chemical compounds useful as pesticides consists of alkylpolyoxysulfinyl and alkylpolythiosulfinyl derivatives of carbamate esters. The preparation of these compounds and their formulation to control insects are exemplified.
    Type: Grant
    Filed: April 11, 1980
    Date of Patent: February 9, 1982
    Assignee: The Regents of the University of California
    Inventors: Mohamed A. H. Fahmy, Tetsuo R. Fukuto, Teruomi Jojima
  • Patent number: 4314082
    Abstract: This invention provides derivatives of 2-Amino-6,7-dihydroxy-tetrahydronaphthalene (ADTN) represented by the formula ##STR1## wherein R is OH, alkyloxy, hydroxyalkyl or acyloxy, and R' is an arylalkyl where the aryl group is benzyl, substituted benzyl, phenyl or substituted phenyl and the alkyl group is a straight or branched chain alkyl having one to twenty carbon atoms; and the pharmaceutically acceptable salts thereof.These derivatives of 2-Amino-6,7-dihydroxytetrahydronaphthalene are useful as inotropes.
    Type: Grant
    Filed: January 23, 1980
    Date of Patent: February 2, 1982
    Assignee: American Hospital Supply Corporation
    Inventor: David M. Stout
  • Patent number: 4310512
    Abstract: Compounds of the formula ##STR1## wherein A, B, C individually represent hydrogen or an alkyl group of 1 to 6 carbon atoms, provided that the total combined number of carbon atoms of A, B and C does not exceed 8;X represents oxygen, sulfur, ##STR2## wherein the alkyl group has 1 to 7 carbon atoms or ##STR3## wherein R and R' represent hydrogen or a methyl group; n represents 1 or 2; andZ represents a hydroxyalkyl group of 2 to 7 carbon atomshave been found to be useful in compositions and methods for counteracting malodors.
    Type: Grant
    Filed: December 4, 1979
    Date of Patent: January 12, 1982
    Assignee: Bush Boake Allen Inc.
    Inventor: Alfred A. Schleppnik
  • Patent number: 4306097
    Abstract: Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have an oxygen atom as part of the chain, or aralkyl which can have an oxygen atom as part of the alkyl chain, their use for pharmacological and medicinal purposes, intermediates therefor and processes for their preparation.
    Type: Grant
    Filed: September 8, 1980
    Date of Patent: December 15, 1981
    Assignee: Pfizer Inc.
    Inventors: Charles A. Harbert, Michael R. Johnson, Lawrence S. Melvin, Jr.
  • Patent number: 4303649
    Abstract: The invention concerns new topical anti-inflammatory 1-phenyl-2-aminoethanol derivatives of the general formula:R.sup.1 .multidot.CH(OH).multidot.CH.sub.2 NH.multidot.CR.sup.2 R.sup.3 .multidot.A.sup.1 .multidot.NH[CO.multidot.Y.multidot.NH].sub.n .multidot.Qwherein R.sup.1 is a phenyl bearing specific combinations of (2-12C)alkanoyloxy,[(2-12C)alkanoyloxy]methyl,chloro and amino substituents, R.sup.2 and R.sup.3 are independently hydrogen or (1-4C)alkyl, A.sup.1 is a (1-4C)alkylene, Y is a (1-4C)alkylene optionally bearing a (1-4C)alkyl or benzyl, n is an integer from 1 to 4, and Q is an optionally substituted benzoyl, phenylacetyl, or phenoxyacetyl together with the acid-addition salts thereof; and the pharmaceutical compositions thereof, for use in the treatment of inflammatory skin diseases and conditions. The invention also concerns processes for the manufacture of derivatives of formula I.
    Type: Grant
    Filed: May 29, 1979
    Date of Patent: December 1, 1981
    Assignee: Imperial Chemical Industries Limited
    Inventor: Geraint Jones
  • Patent number: 4301044
    Abstract: Zwitterionic surfactant compounds are made readily biodegradable in the environment by the inclusion of a biochemically and/or hydrolytically labile chemical linkage located between the cationic and anionic charge centers of the compounds and anywhere from the second to the tenth atom distant from the cationic charge center. The biodegradable linkage is preferably an ester or amide. The alkoxylated zwitterionic surfactants herein exhibit outstanding particulate soil removal performance and are also effective in removing oily soils from fabrics, in addition to being readily biodegradable. Also described are detergent compositions containing the zwitterionic surfactants, and, optionally containing cosurfactants and detergent builders.
    Type: Grant
    Filed: January 22, 1980
    Date of Patent: November 17, 1981
    Assignee: The Procter & Gamble Company
    Inventors: George E. Wentler, Joseph McGrady, Eugene P. Gosselink, William A. Cilley
  • Patent number: 4289903
    Abstract: There are provided certain p-phenylalkoxy phenylurea and thiourea compounds useful for the control of undesirable plants in the presence of agronomic crops and to methods for the preparation of said phenylalkoxy phenylurea and thiourea compounds.
    Type: Grant
    Filed: June 25, 1979
    Date of Patent: September 15, 1981
    Assignee: American Cyanamid Company
    Inventors: David M. Spatz, Barrington Cross
  • Patent number: 4284628
    Abstract: A compound represented by the formula: ##STR1## wherein R.sub.1 is hydrogen, lower alkylcarbonyl, lower alkoxycarbonyl, phenoxycarbonyl, lower alkylsulfonyl or lower alkylcarbamoyl, R.sub.2 is phenyl; phenyl substituted by one or more members selected from the group consisting of lower alkyl, lower alkoxy, lower alkylthio, lower alkoxycarbonyl, halogen, formyl, cyano, thiocyano, nitro, lower alkylsulfinyl, lower alkylsulfonyl, lower alkylcarbonyl, acetylamino or phenyl; or naphthyl, with the proviso that when R.sub.1 is hydrogen or lower alkylcarbonyl, R.sub.2 is the said substituted phenyl or naphthyl, and use thereof as a fungicide.
    Type: Grant
    Filed: August 13, 1979
    Date of Patent: August 18, 1981
    Assignee: Nippon Kayaku Kabushiki Kaisha
    Inventors: Taizo Nakagawa, Seiji Mochizuki, Kaoru Ohmori, Kengo Koike, Mineo Maruyama, Eiichi Tanaka
  • Patent number: 4276226
    Abstract: Aromatic diketones and diesters are provided of the formula ##STR1## wherein R is independently methyl or chloro; R' is independently hydrogen or R; R.sup.2 is 1,4-phenylene, 1,3-phenylene, 2,6-naphthylene, 4,4'-biphenylene, or 4,4'-biphenylene ether; and R.sup.3 is hydrogen or ##STR2## where R.sup.4 is a hydrocarbon group of 1-10 carbon atoms.
    Type: Grant
    Filed: July 23, 1979
    Date of Patent: June 30, 1981
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Robert A. Clement, Burton C. Anderson
  • Patent number: 4275219
    Abstract: The invention relates to a novel process and novel intermediates useful in the preparation of sympathomimetic amines. The pharmacologically useful final products, which are acyl derivatives of mono- and dihydroxy aromatic amines (e.g., catechol amines) can be prepared in optically active or racemic form by reacting the corresponding mono- or dihydroxy aromatic amine with a reagent capable of forming the N-tert-butoxycarbonyl derivative thereof; reacting the novel intermediate thus obtained with an acyloxymethyl chloride to afford the corresponding novel mono- or diacylated N-protected aromatic amine; and removing the N-protecting group therefrom.
    Type: Grant
    Filed: September 24, 1979
    Date of Patent: June 23, 1981
    Assignee: INTERx Research Corporation
    Inventor: Jacob A. Zupan
  • Patent number: 4260809
    Abstract: This invention relates to copolymerizable ultraviolet light absorber compounds having the formula ##STR1## where R is alkyl C.sub.1 --C.sub.6, substituted alkyl C.sub.1 --C.sub.6 or alkoxy C.sub.1 --C.sub.6 ; andY is a copolymerizable radical selcted from acryloylC.sub.3 --C.sub.12, acryloxyalkyl C.sub.3 --C.sub.12, acryloxyhydroxyalkylC.sub.3 --C.sub.12, and alkylacryloxyhydroxyalkyl C.sub.3 --C.sub.12.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: April 7, 1981
    Assignee: GAF Corporation
    Inventors: Bruce A. Gruber, Donald H. Lorenz
  • Patent number: 4250183
    Abstract: N-substituted .omega.-aminoalkanoyl-.omega.-aminoalkanoic acids and their pharmacologically-acceptable salts (with a base) are useful, e.g., in pharmaceutical-composition form for the treatment or prophylaxis of diseases which are based on inadequate performance of the pancreas, the bile and/or the liver. The compounds are prepared, e.g., by reacting an N-(mono- or di-substituted) .omega.-amino-alkanoic acid with an N-(unsubstituted or monosubstituted) .omega.-aminoalkanoic acid.
    Type: Grant
    Filed: December 15, 1978
    Date of Patent: February 10, 1981
    Assignee: BYK Gulden Lomberg Chemische Fabrik GmbH
    Inventor: Walter Krastinat
  • Patent number: RE31731
    Abstract: Compounds of the formula ##STR1## wherein X is a hydrogen atom, a halogen atom, a trihalomethyl group, an alkyl group, or a cyano group,Y is a hydrogen atom, or a trihalomethyl group, andZ is an alkoxy group, an alkoxyalkoxy group, a hydroxyalkoxy group, an alkyl group, a halogen atom, an alkylamino group, a dialkylamino group, an alkylthio group, a carboxy group, a carbalkoxy group, a carboxyalkoxy group, a carbalkoxyalkoxy group, a carboxyalkyl group, a carbalkoxyalkyl group, a dialkylureido group, an alkanoylamino group, or carbalkoxyamino group,and compositions containing these compounds exhibit herbicidal activity.
    Type: Grant
    Filed: September 1, 1978
    Date of Patent: November 13, 1984
    Inventors: Horst O. Bayer, Colin Swithenbank, Roy Y. Yih