Additional Nitrogen In Acid Moiety Patents (Class 560/169)
  • Patent number: 10086013
    Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R?, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.
    Type: Grant
    Filed: November 1, 2016
    Date of Patent: October 2, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Yizhou Dong, Kevin Thomas Love, Robert S. Langer, Daniel Griffith Anderson, Delai Chen, Yi Chen, Arturo Jose Vegas, Akinleye C. Alabi, Yunlong Zhang
  • Publication number: 20150119251
    Abstract: Provided is an agricultural plant-protecting agent including a dipeptide derivative or an agro-pharmaceutically acceptable salt thereof as an active ingredient, which has a plant disease-preventing effect, a plant growth-promoting effect, and a plant immunity-activating effect.
    Type: Application
    Filed: April 18, 2013
    Publication date: April 30, 2015
    Inventors: Kyung Seok Park, Jin Woo Park, Se Won Lee, Surk Sik Moon, In Seok Hong
  • Publication number: 20150094314
    Abstract: A method of modulating ribonucleotide reductase activity in a neoplastic cell includes administering to the cell an amount of a ribonucleotide reductase allosteric modulator (RRAmod), the amount being effective to inhibit neoplastic cell growth.
    Type: Application
    Filed: March 21, 2013
    Publication date: April 2, 2015
    Inventor: Chris Dealwis
  • Publication number: 20150079163
    Abstract: The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 19, 2015
    Inventors: Bassam B. DAMAJ, Richard Martin
  • Publication number: 20150072942
    Abstract: Disclosed herein is a method for reducing the rate of degradation of proteins in an animal, comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.
    Type: Application
    Filed: April 8, 2014
    Publication date: March 12, 2015
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: Julian Adams, Yu-Ting Ma, Ross L. Stein, Matthew Baevsky, Louis Grenier, Louis Plamondon
  • Publication number: 20150056114
    Abstract: Disclosed are a compound including an oxalate, a carbon dioxide absorbent including the same, a method of preparing the carbon dioxide absorbent and a method of removing carbon dioxide, which may overcome issues of high recycling energy and low absorptivity of a conventional carbon dioxide absorbent to considerably reduce recycling energy and absorb a greater amount of carbon dioxide per unit absorbent, so that a size of a carbon dioxide absorption tower may be reduced and a less amount of recycling energy may be used, contributing to a substantial decrease in device manufacture costs and management costs.
    Type: Application
    Filed: December 24, 2013
    Publication date: February 26, 2015
    Applicant: KOREA INSTITUTE OF ENERGY RESEARCH
    Inventors: Soon Kwan JEONG, Yeo II YOON, Sung Chan NAM, Soo Hyun CHOI, Sung Ho YOON, Nam Seok KIM, Bon Sik JOO
  • Publication number: 20150030866
    Abstract: A photochromic curable composition containing, as a radically polymerizable monomer component (A), a (meth)acrylic-amide polymerizable monomer (A1) having 2 to 6 (meth)acryloyloxy groups and 2 to 6 divalent amide groups (—NHCO—), and a non-amide polymerizable monomer (A2) having at least 3 radically polymerizable groups but having no amide bond. From the photochromic composition, there can be obtained a photochromic cured body having excellent photochromic properties such as a high color density, a high fading rate, and excellent mechanical strength.
    Type: Application
    Filed: April 17, 2013
    Publication date: January 29, 2015
    Applicant: TOKUYAMA CORPORATION
    Inventors: Shinobu Izumi, Junji Takenaka, Junji Momoda
  • Publication number: 20150030670
    Abstract: The present invention is directed to a new class of lipids, more specifically ether-lipids having a polar headgroup, as well as vesicles comprising these lipids, methods of their preparation as well as their uses in medical applications, wherein the ether-lipids are represented by general formula I
    Type: Application
    Filed: March 11, 2013
    Publication date: January 29, 2015
    Applicant: MERCK PATENT GmbH
    Inventors: Michael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
  • Publication number: 20150030669
    Abstract: The present invention is directed to carrier systems comprising ether-lipids conjugated to one or more bioactive ligands and exposed on the surface of the carrier system for use in targeted delivery and/or antigen display systems. Optionally one or more further bioactive agents may be encapsulated or embedded within or attached to or adsorbed onto the carrier system. The present invention is further directed to methods of their preparation and their uses in medical applications, such as targeted delivery of bioactive agents to specific tissues or cells and antigen display systems for the study, diagnosis, and treatment of traits, diseases and conditions that respond to said bioactive agents.
    Type: Application
    Filed: March 11, 2013
    Publication date: January 29, 2015
    Applicant: MERCK PATENT GMBH
    Inventors: Michael Wilhelm Platscher, Raymond Behrendt, Viola Groehn, Simone Rachel Hoertner, Marco Silvio Passafaro, Finn Bauer
  • Publication number: 20150023900
    Abstract: A process for preparing amino acid-modified siloxanes that can be carried out under mild conditions is provided as well as organically modified silicones for care formulations for skin, hair and textiles that are toxicologically unobjectionable.
    Type: Application
    Filed: July 15, 2014
    Publication date: January 22, 2015
    Applicant: Evonik Industries AG
    Inventors: Wilfried Knott, Frauke Henning, Sadik Amajjahe, Sarah Krauskopf, Michael Fiedel, Olga Jazkewitsch, Christian Hartung
  • Publication number: 20140364642
    Abstract: [Problem] Provision of a novel compound having read-through activity and a drug for the treatment of nonsense mutation-type disease containing this compound. [Solution] A compound represented by the following general formula (1): and a pharmaceutical composition containing this compound.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 11, 2014
    Applicant: THE UNIVERSITY OF TOKYO
    Inventors: Yoshio HAYASHI, Akihiro TAGUCHI, Fumika YAKUSHIJI, Yuri YAMAZAKI, Ryoichi MATSUDA, Masataka SHIOZUKA
  • Publication number: 20140348767
    Abstract: Provided is a compound capable of gelling various aqueous compositions containing salt, acid and the like. An amphoteric ion-type basic amino acid derivative represented by the formula (1A): wherein each substituent is as defined in DESCRIPTION, or a salt thereof.
    Type: Application
    Filed: August 6, 2014
    Publication date: November 27, 2014
    Applicant: AJINOMOTO CO., INC.
    Inventors: Kenji HANABUSA, Masahiro SUZUKI, Takanori SUGIMOTO
  • Publication number: 20140339462
    Abstract: The present invention discloses compounds of 4,4?-diaminostilbene-2,2?-disulphonic acid which are useful as optical brighteners to bleach fibres, cellulose and in particular paper and cardboard.
    Type: Application
    Filed: July 17, 2014
    Publication date: November 20, 2014
    Inventors: Ferruccio Berte', Patrick Alborghetti
  • Publication number: 20140342962
    Abstract: An object of the present invention is to provide an oil soluble compound and a lubricating composition and method of using the same in a differential. The compound can be of formula R?N((CH2)2CONHR?)2, wherein R? can be H or a C8-28 hydrocarbyl group wherein up to 4 carbon atoms in the hydrocarbyl group may optionally be replaced by nitrogen or oxygen atoms, and R? can be H or a C8-28 hydrocarbyl group. The invention further provides a method of producing an oil soluble compound suitable for limited slip performance. The method comprises preparing a Michael adduct from an acrylate and an alkylamine of formula R?NH2, followed by subjecting the Michael adduct to an amidation reaction with a further alkylamine of formula R?NH2.
    Type: Application
    Filed: December 27, 2012
    Publication date: November 20, 2014
    Applicant: The Lubrizoi Corporaton
    Inventors: Shubhamita Basu, Daniel J. Saccomando
  • Publication number: 20140332471
    Abstract: A pentaerythritol core, phosphonic acid terminated dendrimer, its preparation method and application are provided. A preparation method of the pentaerythritol core, phosphonic acid terminated dendrimer (PETA-ADA-12PO3H2) comprises steps of processing Michael addition reaction on pentaerythritol tetraacrylate (C(CH2OCOCH2=CH2)4) and alkylidene diamine (NH2CH2(CH2)nNH2), wherein n is an integer from 1 to 5, so as to obtain pentaerythritol core, amino group terminated dendrimer, and modifying the amino group by methylene phosphonic acid to obtain the PETA-ADA-12PO3H2 having a chemical formula of C[CH2OCOCH2CH2N(CH2PO3H2)CH2(CH2)nN(CH2PO3H2)2]4, wherein n is an integer from 1 to 5.
    Type: Application
    Filed: September 9, 2013
    Publication date: November 13, 2014
    Applicant: Tongji University
    Inventors: Bingru Zhang, Fengting Li, Hongmei You
  • Publication number: 20140329984
    Abstract: Disclosed are salt compositions of lysinol and dicarboxylic acids; and lysinol derived polymers including polyamide, polyimide, polyurea, cross-linked polyurea comprising urethane linkages, polyurea foams, cross-linked polyurea foams, and lysinol-epoxy thermoset.
    Type: Application
    Filed: July 22, 2014
    Publication date: November 6, 2014
    Inventors: DAVID NEIL MARKS, KENNETH GENE MOLOY, MARK A. SCIALDONE
  • Publication number: 20140308304
    Abstract: The present invention relates to novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mRNA both in vitro and in vivo. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
    Type: Application
    Filed: December 7, 2012
    Publication date: October 16, 2014
    Inventors: Muthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, Akin Akinc, Shigeo Matsuda, Martin Maier
  • Publication number: 20140303063
    Abstract: The invention relates to a washing or cleaning agent, wherein use thereof generates hydrogel layers surfaces, comprising a hydrogel former having a molecular weight less than 3500 g/Mol, wherein the hydrogel former is water-soluble at concentrations below the minimum gel formation concentration, wherein the minimum gel formation concentration is the concentration at which a yield point of at least 0.05 Pa is formed in a binary solution of water and hydrogel former at T=25° C., and wherein said minimum gel formation concentration lies below 2 wt % of hydrogel former, relative to the system consisting of water and hydrogel former. The washing or cleaning agents according to the invention enable the hydrophiliation of surfaces, and the specific and retarded releasing of active substances embedded in the hydrogel layers, such as aromatic substances or antimicrobial active substances, for example.
    Type: Application
    Filed: April 3, 2014
    Publication date: October 9, 2014
    Applicant: Henkel AG & Co. KGaA
    Inventors: Christian Kropf, Matthias Sunder, Peter Schmiedel, Ulrich Pegelow, Joerg C. Tiller, Marco Mueller, Kaoru Tachikawa, Yvonne Willemsen
  • Publication number: 20140288142
    Abstract: The invention relates to nitric oxide donor compounds and their use for treating cardiovascular diseases, inflammation, pain, fever, gastrointestinal disorders, ophthalmic diseases, hepatic disorders, renal diseases, respiratory disorders, immunological diseases, bone metobolisms dysfunctions, central and peripheral nervous system diseases, sexual dysfunctions, infectious diseases, for the inhibition of platelet aggregation and platelet adhesion, for treating pathological conditions resulting from abnormal cell proliferation, vascular diseases. The invention also relates to compositions comprising at least one nitric oxide releasing compounds of the invention and composition comprising at least one nitric oxide releasing compounds according to the invention and at least one 15 therapeutic agent.
    Type: Application
    Filed: June 9, 2014
    Publication date: September 25, 2014
    Inventors: Nicoletta ALMIRANTE, Stefano BIONDI, Ennio ONGINI, Laura STORONI, Alessia NICOTRA
  • Publication number: 20140275407
    Abstract: A composition having a polyurea made by reacting a polyisocyanate with one of the below compounds. The value x is 2 or 3. A method of: providing a polyisocyanate and one of the below compounds, spraying the polyisocyanate and the compound with a plural component pump onto a surface to form a mixture, and allowing the mixture to cure to a polyurea.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: The Government of the United States of America, as represented by the Secretary of the Navy
    Inventors: Arthur A Webb, Jozef Verborgt, Keith E Lucas
  • Publication number: 20140245929
    Abstract: A particulate material for the production of a cement foam which material includes particles including, attached to the particle surface, a surfactant which renders the particles hydrophilic, the surfactant including a moiety which is hydrolysable under alkaline conditions, which surfactant, after loss of the moiety by alkaline hydrolysis, renders the particles partially hydrophobic.
    Type: Application
    Filed: September 5, 2012
    Publication date: September 4, 2014
    Applicant: LAFARGE
    Inventors: Ellis Gartner, Lê-Chiên Hoang
  • Publication number: 20140243411
    Abstract: The present invention relates to topical trisodium diethylenetriamine pentaacetic acid (DTPA) prodrug formulations and methods of using the same.
    Type: Application
    Filed: October 19, 2012
    Publication date: August 28, 2014
    Inventors: Michael Jay, Russell Mumper, Yong Zhang
  • Publication number: 20140200257
    Abstract: The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 17, 2014
    Applicant: ALNYLAM PHARMACEUTICALS, INC.
    Inventors: Kallanthottathil G Rajeev, Muthiah Manoharan, Muthusamy Jayaraman, Martin Maier, Jayaprakash K. Nair, David Butler
  • Publication number: 20140161830
    Abstract: Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 12, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Daniel Griffith Anderson, Kathryn Ann Whitehead, Joseph R. Dorkin, Arturo Jose Vegas, Yunlong Zhang
  • Patent number: 8735623
    Abstract: The invention relates to the field of pharmaceutical chemistry, specifically to processes for preparing biologically active substances (BAS), in particular creatine amides. What is proposed is a process for preparing creatine amides which comprises treating creatine with para-toluenesulfonic acid in an organic solvent with subsequent reaction of the resultant complex with compounds comprising a primary or secondary amino group in the presence of a condensing agent and a base which are introduced subsequently. The claimed process makes it possible to increase the yield of the end product by 2-5 times in comparison with known similar processes and also to extend the range of the compounds prepared.
    Type: Grant
    Filed: September 28, 2010
    Date of Patent: May 27, 2014
    Assignee: Vertex Closed Joint Stock Company
    Inventors: Sergej Vladimirovich Burov, Olga Sergeevna Veselkina, Maria Victorovna Leko
  • Publication number: 20140121270
    Abstract: Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“BES”) of a patient, are disclosed. The BES provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient. The invention discloses systems and methods for estimating fractional gluconeogenesis, which is the % of glucose production that comes from gluconeogenesis (“GNG”), as opposed to glycogenolysis (“GLY”), the other form of glucose production. Nutritional formulations, materials, cocktails and methods for feeding patients by parenteral and other means are disclosed. The amount, type and rate of such nutritional feeding are typically based upon the above estimating. The invention discloses formulations that contain labels, such as deuterium, for medical diagnostics, such as for estimating BES and fractional gluconeogenesis.
    Type: Application
    Filed: August 2, 2013
    Publication date: May 1, 2014
    Applicant: Run Them Sweet, LLC
    Inventors: Michael A. Horning, George A. Brooks
  • Publication number: 20140113884
    Abstract: Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
    Type: Application
    Filed: April 4, 2012
    Publication date: April 24, 2014
    Inventors: John David Imig, William B. Campell, John Russell Falck
  • Publication number: 20140094399
    Abstract: Poly(?-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
    Type: Application
    Filed: September 17, 2013
    Publication date: April 3, 2014
    Applicant: Massachusetts Institute of Technology
    Inventors: Robert S. Langer, David M. Lynn, David A. Putnam, Mansoor M. Amiji, Daniel Griffith Anderson
  • Publication number: 20140094393
    Abstract: Compositions and methods of inhibiting the formation of hydrate agglomerates in fluids including water, gas, and optionally liquid hydrocarbons are disclosed. The compositions may include counterions, such as halides or carboxylates. The compositions may also include a thermodynamic hydrate inhibitor, a kinetic hydrate inhibitor, an additional anti-agglomerant, an asphaltene inhibitor, a paraffin inhibitor, a corrosion inhibitor, a scale inhibitor, an emulsifier, a water clarifier, a dispersant, an emulsion breaker, and combinations thereof.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicant: Ecolab USA, Inc.
    Inventor: Peter A. Webber
  • Patent number: 8658702
    Abstract: Novel macromolecules for filtering contaminants from water and non-aqueous solutions. Molecules such as polyethyleneimine (PEI) may be functionalized, cross-linked, and/or quaternized to improve their binding capacity or selectivity with particular water contaminants such as bromide, nitrate, and sulfate. The macromolecules may be either recyclable or non-recyclable, and may be recovered or separated from water using means such as ultrafiltration, flocculation, or immobilization on a substrate.
    Type: Grant
    Filed: December 17, 2010
    Date of Patent: February 25, 2014
    Inventors: Mamadou Diallo, Changjun Yu
  • Publication number: 20140046003
    Abstract: The present invention provides a method for preparing a sample characterized by binding a substance A containing a hydrazide group to a sugar chain and/or a sugar derivative via hydrazone formation between the hydrazide group of the substance A and the reducing end of the sugar chain and/or the sugar derivative thereby to enable the separation and purification of the sugar chain and/or the sugar derivative for an analytical sample from a biological sample containing the sugar chain and/or the sugar derivative by a simple operation.
    Type: Application
    Filed: September 25, 2013
    Publication date: February 13, 2014
    Applicant: Sumitomo Bakelite Company Limited
    Inventors: Hideyuki SHIMAOKA, Shinichiro NISHIMURA, Yasuro SHINOHARA, Yoshiaki MIURA, Jun-ichi FURUKAWA
  • Publication number: 20140045798
    Abstract: The present invention provides a compound of Formula Ia, wherein R1 is H or phosphate and the double bond is between N1 and C1 or between N2 and C1; R2 is a mitochondrial targeting moiety; R3 an alkyl, alkylaryl, alkylheteroaryl spacer group, a cleavable linker, or absent; R4 is H or an alkyl, aryl, or heteroaryl group; and R5 is alkyl, aryl, or heteroaryl; or N1 C1, and N3 together form a heterocyclic ring containing at least 5 atoms, wherein N1, N3, and R1-R5 are as defined above, or N3 and R5 together form a heterocyclic ring containing at least four atoms; or a pharmaceutically acceptable salt or prodrug thereof.
    Type: Application
    Filed: October 18, 2013
    Publication date: February 13, 2014
    Applicant: Gencia Corporation
    Inventor: Shaharyar Khan
  • Publication number: 20140024815
    Abstract: A dendritic structure includes a core and repeating units, wherein the repeating units comprise units of the type ABxCy, wherein x is 2, 3, or 4, wherein y is 1, 2, or 3, wherein C is selected from the group consisting of azides and alkynes, and wherein every repeating unit is bound to at least one other unit with at least one bond selected from the group consisting of the group consisting of an ester, an amide, a thioether, an ether, a urethane, an amine, and an imine. Advantages include that a “one-pot” growth of the dendritic structure is possible. It is possible to have more functional groups in a dendritic structure. It is possible to add different functional groups simultaneously both to an inner layer and to an outer layer in a dendritic structure.
    Type: Application
    Filed: September 25, 2013
    Publication date: January 23, 2014
    Applicant: POLYMER FACTORY SWEDEN AB
    Inventors: Anders HULT, Michael MALKOCH, Per ANTONI
  • Publication number: 20140012028
    Abstract: A compound represented by following formula (I): A-L-{D1-(E)q-D2-(B)m—Z1—R}p. In the formula, A represents a p-valent chain or cyclic residue; L represents a single bond or a divalent linking group; p represents an integer of 2 or more; D1 represents a carbonyl group (—C(?O)—) or a sulfonyl group (—S(?O)2—); D2 represents a carbonyl group (—C(?O)—), a sulfonyl group (—S(?O)2—), a carboxyl group (—C(?O)O—), a sulfonyloxyl group (—S(?O)2O—), a carbamoyl group (—C(?O)N(Alk)-) or a sulfamoyl group (—S(?O)2N(Alk)-); E represents a divalent group; and R represents a hydrogen atom, a substituted or non-substituted C8 or longer alkyl group, a perfluoroalkyl group or a trialkylsilyl group.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 9, 2014
    Applicant: FUJIFILM Corporation
    Inventors: Saisuke WATANABE, Hiyoku Nakata, Ken Kawata
  • Publication number: 20140005351
    Abstract: The invention relates to a compound of the following formula (I): to its method for making it and to its uses for preparing a polymer useful for increasing the heat resistance of polymeric compositions.
    Type: Application
    Filed: November 9, 2011
    Publication date: January 2, 2014
    Applicants: INSTITUT NATIONAL DE LA RECHERCHE ARGONOMIQUE, FAURECIA INTERIEUR INDUSTRIE
    Inventors: Laurence Dufrancatel, Pauline Kannengiesser, Gregory Yhuel, Sinisa Marinkovic, Boris Estrine, Patrice Dole
  • Patent number: 8618025
    Abstract: Disclosed and claimed is a composition and method of inhibiting the formation of hydrate agglomerates in a fluid comprising water, gas, and optionally liquid hydrocarbon comprising adding to the fluid an effective anti-agglomerant amount of the following formula and optionally salts thereof: wherein each R1 is independently absent, C1-C10 alkyl, benzyl, or H; wherein R2 is C1-C10 alkyl; wherein R3 C1-C10 alkyl; and wherein R4 is C4-C22 alkyl or alkenyl.
    Type: Grant
    Filed: December 16, 2010
    Date of Patent: December 31, 2013
    Assignee: Nalco Company
    Inventor: Peter A. Webber
  • Publication number: 20130338313
    Abstract: The invention is based on the discovery that a remarkable improvement in the performance of maleimide thermosets can be achieved by incorporating amide-extended maleimides into an adhesive formulation. Amide-extended maleimides described herein can be used to toughen bismaleimide thermosetting materials without sacrificing any thermal stability. Amide-extended maleimides are readily prepared by reacting a bismaleimide with an appropriate amine via the well-known Michael addition reaction. Acylation of the resulting secondary amines provides the amide-extended maleimide. The acylating agent can also be used to introduce polymerizable functional groups into the backbones of these thermoset monomers. Amide-extended acrylate and methacrylate monomers can also be prepared.
    Type: Application
    Filed: August 19, 2013
    Publication date: December 19, 2013
    Applicant: Designer Molecules, Inc.
    Inventors: Stephen M. Dershem, Farhad G. Mizori
  • Patent number: 8609900
    Abstract: The present invention is in relation to a dendritic molecule having symmetrically sited branches having four or more generations of dendrimers wherein the branch points are tertiary amines linked together with oxygen atom of ether and the heteroatoms are separated by a substituted or non-substituted linear three methylene linker. In addition the invention also provides a process to prepare such dendritic macromolecules.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: December 17, 2013
    Assignee: Indian Institute of Science
    Inventors: Jayaraman Narayanaswamy, Jayamurugan Govindasamy
  • Publication number: 20130317134
    Abstract: The present invention relates to a compound of formula (I) wherein R1, R2 each independently of the other are identical or different organic radicals which do not contain Zerewitinoff-active hydrogen, and R4, R5, R6 each independently of the others are saturated, linear or branched organic radicals which do not contain Zerewitinoff-active hydrogen and which are also optionally substituted in the chain by heteroatoms, for use in a polyurea system which is provided in particular for sealing, bonding, gluing or covering cell tissue. The invention further provides a polyurea system comprising the compound according to the invention, and a metering system for the polyurea system according to the invention.
    Type: Application
    Filed: February 6, 2012
    Publication date: November 28, 2013
    Applicant: Bayer Intellectual Property GmbH Creative Campus Monheim
    Inventors: Heike Heckroth, Christoph Eggert
  • Patent number: 8580852
    Abstract: The disclosure provides a series of 2-oxoamides based on dipeptides and pseudodipeptides, which were synthesized and their activities toward two human intracellular phospholipases A2 (GIVA CPLA 2 and GVIA 1PLA 2) and one human secretory phospholipase A2 (GV sPLA 2) were evaluated. Derivatives containing a free carboxyl group are selective GIVA cPLA 2 inhibitors. A derivative based on the ethyl ester of an ether pseudodipeptide is the first 2-oxoamide, which preferentially inhibits GVIA iPLA 2. The effect of 2-oxoamides on the generation of arachidonic acid from RAW 264.7 macrophages was also studied. It was found that selective GIVA cPLA 2 inhibitors preferentially inhibited cellular arachidonic acid release; in which one pseudodipeptide gave an IC50 value of 2 ?M.
    Type: Grant
    Filed: April 19, 2010
    Date of Patent: November 12, 2013
    Assignee: The Regents of the University of California
    Inventors: Edward A. Dennis, George Kokotos, Violetta Constantinou-Kokotou
  • Publication number: 20130267562
    Abstract: 2R-dodecyl 2-(N,N dimethylamino)-propionate (R-DDAIP) provides an unexpectedly improved activity in facilitating transport of a pharmaceutically active compound across biological membranes and tissues, compared to S-DDAIP of the same enantiomeric purity, or racemic DDAIP. Purified S-DDAIP is also provided.
    Type: Application
    Filed: November 30, 2011
    Publication date: October 10, 2013
    Applicant: NEXMED HOLDINGS, INC
    Inventors: Bassam B. Damaj, Richard Martin
  • Publication number: 20130245264
    Abstract: The object of the present invention is to provide a compound which is useful as a production intermediate of pyrazine carboxamide derivative such as 6-fluoro-3-hydroxy-2-pyrazine carboxamide. The present invention provides a pyrazino[2,3-d]isoxazole derivative represented by the formula (I): wherein X represents a halogen atom, a hydroxyl group or a sulfamoyloxy group, and Y represents —C(?O)R or —CN; wherein R represents a hydrogen atom, an alkoxy group an aryloxy group, an alkyl group, an aryl group or an amino group.
    Type: Application
    Filed: May 3, 2013
    Publication date: September 19, 2013
    Applicants: TOYAMA CHEMICAL CO., LTD., FUJIFILM Corporation
    Inventors: Kouki NAKAMURA, Takeshi MURAKAMI, Hiroyuki NAITOU, Naoyuki HANAKI, Katsuyuki WATANABE
  • Publication number: 20130237580
    Abstract: The present invention relates to novel peptidomimetic compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signalling pathway. The invention also relates to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.
    Type: Application
    Filed: March 7, 2013
    Publication date: September 12, 2013
    Applicant: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
    Inventors: POTTAYIL GOVINDAN NAIR SASIKUMAR, MURALIDHARA RAMACHANDRA, SEETHARAMAIAH SETTY SUDARSHAN NAREMADDEPALLI
  • Patent number: 8519156
    Abstract: The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Grant
    Filed: December 30, 2012
    Date of Patent: August 27, 2013
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20130189287
    Abstract: The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs.
    Type: Application
    Filed: December 21, 2012
    Publication date: July 25, 2013
    Applicants: Innate Pharma
    Inventors: Innate Pharma, Paul Scherrer Institut
  • Patent number: 8487126
    Abstract: The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and specificity to an intended organ. The objective of the present invention is also to provide an intermediate compound produced by the said production process. The process for preparation of the diethylenetriaminepentaacetic acid derivative (I): wherein R1 to R5 are independently C1-6 alkyl groups; comprising the steps of: reacting a diethylenetriaminepentaacetic acid pentaester with a halogenated ally compound in an aprotic solvent; removing the excess halogenated ally compound (III); and reacting a reaction product of the diethylenetriaminepentaacetic acid pentaester and the halogenated ally compound with a base in a solvent.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: July 16, 2013
    Assignee: The University of Tokushima
    Inventors: Hisao Nemoto, Tomoyuki Kawamura, Kenji Yatsuzuka, Masaki Kamiya
  • Publication number: 20130165659
    Abstract: The present invention relates to a novel method for preparing a compound of formula (2) as the intermediate, which can be effectively used for preparation of a compound of formula (1) exhibiting good inhibitory activity against dipeptidyl peptidase IV enzyme.
    Type: Application
    Filed: August 25, 2011
    Publication date: June 27, 2013
    Applicant: LG LIFE SCIENCES LTD.
    Inventors: Bong Chan Kim, Kyu Young Kim, Hee Bong Lee, Ji Eun An, Kyu Woong Lee
  • Publication number: 20130136832
    Abstract: This invention discloses a method of preservation of a food product comprising the step of adding 1) a first component comprising between 10 ppm and 1% of a biocidal salt of N?—(C1-C22) alkanoyl di-basic amino acid alkyl (C1-C22) ester cationic biocidal molecule with an anionic counterion, and 2) a second component comprising from 10 ppm to 1% by weight an acyl monoglyceride, directly to a food product. The preferred cationic biocidal molecule comprises N?-lauroyl-L-arginine ethyl ester (“LAE”). The invention also discloses the method of preservation of a food product using salts of a N?—(C1-C22) alkanoyl di-basic amino acid alkyl (C1-C22) ester cationic biocidal molecule and an anionic counterion with or without a monoglyceride of a fatty acid, whereby the packaging film is compounded with the salts and the optional monoglyceride of a fatty acid.
    Type: Application
    Filed: April 4, 2011
    Publication date: May 30, 2013
    Inventors: Anthony Joseph Sawyer, Richard F. Stockel
  • Publication number: 20130116446
    Abstract: The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: December 30, 2012
    Publication date: May 9, 2013
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Bezwada Biomedical, LLC
  • Publication number: 20130072462
    Abstract: The present invention provides a compound of Formula 1a, wherein R1 is H or phosphate and the double bond is between N? and C? or between N2 and C1; R2 is a mitochondrial targeting moiety; R3 an alkyl, alkylaryl, alkylheteroaryl spacer group, a cleavable linker, or absent; R4 is H or an alkyl, aryl, or heteroaryl group; and R5 is alkyl, aryl, or heteroaryl; or N? C?, and N3 together form a heterocyclic ring containing at least 5 atoms, wherein N1, N3, and R1-R5 are as defined above, or N3 and R5 together form a heterocyclic ring containing at least four atoms; or a pharmaceutically acceptable salt or prodrug thereof.
    Type: Application
    Filed: August 17, 2012
    Publication date: March 21, 2013
    Applicant: Gencia Corporation
    Inventor: Shaharyar Khan