Additional Nitrogen In Acid Moiety Patents (Class 560/169)
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Publication number: 20110008634Abstract: A rust inhibitor usable for metal surface coating includes, as an effective component, a compound containing a chelate group, and a long chain alkyl group and/or a cyclic alkyl group, which are bonded by an ester bond or other bonds.Type: ApplicationFiled: July 2, 2009Publication date: January 13, 2011Applicants: AUTONETWORKS TECHNOLOGIES, LTD., SUMITOMO WIRING SYSTEMS, LTD., SUMITOMO ELECTRIC INDUSTRIES, LTD., KYUSHU UNIVERSITYInventors: Tatsuya Hase, Makoto Mizoguchi
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Publication number: 20100331345Abstract: The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ?-amyloid peptide.Type: ApplicationFiled: February 5, 2007Publication date: December 30, 2010Inventors: Song Li, Guochao Liao, Junhai Xiao, Aihua Nie, Lili Wang, Wu Zhong, Zhibing Zheng
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Publication number: 20100323990Abstract: The present invention provides the use of prodrugs of pelorol and homopelorol, related compounds and pharmaceutical compositions thereof as modulators of SHIP1 activity. A compound or a pharmaceutical composition of the present invention may be used for the treatment or prophylaxis of an inflammatory, neoplastic, hematopoetic or immune disorder or condition in addition to other disorders and conditions.Type: ApplicationFiled: June 21, 2007Publication date: December 23, 2010Applicant: THE UNIVERSITY OF BRITISH COLUMBIAInventors: Raymond Andersen, Matthew Nodwell, Alice Mui
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Publication number: 20100297104Abstract: The present invention is in relation to a dendritic molecule having symmetrically sited branches having four or more generations of dendrimers wherein the branch points are tertiary amines linked together with oxygen atom of ether and the heteroatoms are separated by a substituted or non-substituted linear three methylene linker. In addition the invention also provides a process to prepare such dendritic macromolecules.Type: ApplicationFiled: August 14, 2007Publication date: November 25, 2010Applicant: INDIAN INSTITUTE OF SCIENCEInventors: Jayaraman Narayanaswamy, Jayamurugan Govindasamy
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Publication number: 20100291672Abstract: The present invention provides a reagent for introducing a protein or gene into a cell. The reagent of the present invention is, for example, a reagent for introducing a protein or gene into a cell, which comprises a composition comprising a cationic amino acid type lipid represented by the following formula (I)-1: (wherein in formula (I)-1: L is a single bond, —CONH—, or —S—S—; M1 is —(CH2)k— or —(CH2CH2O)k— (wherein k is an integer between 0 and 14); and m1 and m2 are each independently an integer between 11 and 21 (in this regard, when providing a reagent for introducing a gene into a cell, the case where both m1 and m2 are 15 is excluded)).Type: ApplicationFiled: November 26, 2007Publication date: November 18, 2010Applicant: WASEDA UNIVERSITYInventors: Shinji Takeoka, Naoya Takeda, Hitoshi Kurumizaka, Isao Sakane, Namiko Ikegaya, Yosuke Obata, Syunsuke Saito
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Publication number: 20100286008Abstract: An additive for oils that is capable of imparting oils such as lubricant base oils or fuel oils with superior wear resistance properties or superior friction resistance properties and the like are provided. The additive for oils comprising a compound represented by formula (I): [Chemical Formula 1] (A)m-W—(B)n ??(I) wherein m represents an integer of 0 to 4, n represents an integer of 2 to 6, A represents hydroxy or amino, W represents hydrocarbon or the like, and B represents formula (II): wherein a represents 0 or 1, X represents an oxygen atom or NH, Y represents OR1 or NHR2 (wherein R1 and R2 each represent alkyl optionally having one or more substituents or the like), and Z1 and Z2 each represent a hydrogen atom, NR3R4 (wherein R3 and R4 each represent alkyl optionally having one or more substituents or the like) or the like, and the like are provided.Type: ApplicationFiled: May 9, 2008Publication date: November 11, 2010Applicant: KYOWA HAKKO CHEMICAL CO., LTD.Inventors: Satoshi Hiyoshi, Junya Kishi, Shingo Nakayama, Suguru Ohara, Yukihiro Isogai
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Patent number: 7829337Abstract: A cell-sheet releasing agent of the present invention contains an aminated polyrotaxane. The polyrotaxane constituting the skeleton of the cell-releasing agent of the present invention has a structure in which cavities of a plurality of cyclic molecules are threaded onto a linear molecule and both terminals of the linear molecule have a bulky cap bonded thereto so that the cyclic molecules are not dethreaded from the linear molecule. Furthermore, the aminated polyrotaxane contained in the cell-releasing agent of the present invention is a compound in which at least some of hydroxy groups in the cyclodextrin structure contained in the polyrotaxane are each substituted with a substituent having an amino group. According to this cell-sheet releasing agent, cultured cells anchored to the surface of a container can be released without damaging the cells and without controlling the temperature.Type: GrantFiled: September 9, 2005Date of Patent: November 9, 2010Assignees: Japan Science And Technology Agency, Japan Tissue Engineering Co., Ltd., Japan Advanced Institute of Science And TechnologyInventors: Wanpen Tachaboonyakiat, Masakazu Kato, Tooru Ooya, Nobuhiko Yui
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Patent number: 7820802Abstract: Provided is an industrially safe and useful azodicarboxylic acid bis(2-alkoxyethyl) ester compound that is useful for the Mitsunobu reaction in which it is used in combination with a phosphorus compound to carry out a dehydration condensation reaction, and also useful as an oxidizing agent, and a starting material for various synthetic processes. Also provided are a production intermediate of the above-described compound, and methods for producing these compounds. An azodicarboxylic acid bis(2-alkoxyethyl) ester compound represented by formula (1); wherein A represents an alkyl group having 1 to 10 carbon atoms.Type: GrantFiled: January 30, 2008Date of Patent: October 26, 2010Inventors: Kazutake Hagiya, Takashi Sugimura
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Publication number: 20100203611Abstract: The present invention provides a peptide comprising amino acid sequences R I, F I and R I G C and containing 25 or fewer amino acid residues, and capable of transporting a functional molecule into a cell, and also into a nucleus, more efficiently than a previous PTD.Type: ApplicationFiled: March 6, 2008Publication date: August 12, 2010Inventors: Yukihito Ishizaka, Masakatsu Hasegawa, Satoshi Nohara
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Publication number: 20100197928Abstract: The disclosure relates to a method for preparing a compound of formula (I), wherein P1 and P2 are groups protecting the carboxylic acid and oxyamine functions, starting from pyroglutamic acid (S). The disclosure also relates to novel intermediates.Type: ApplicationFiled: September 12, 2008Publication date: August 5, 2010Applicant: NOVEXELInventors: Alain Priour, Alain Bonnet, Gilles Oddon, Alain Mazurie
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Patent number: 7767844Abstract: The present invention at first prepares a penta-alkyl DTPA and then processes a regioselective hydrolysis over the penta-alkyl DTPA while using a metal ion as a catalyst to obtain a tetra-alkyl DTPA, where, by the above two steps, a monoreactive DTPA derivative is manufactured.Type: GrantFiled: May 23, 2005Date of Patent: August 3, 2010Assignee: Atomic Energy CouncilInventors: Te-Wei Lee, Chia-Hsi Yang, Yen-Sheng Ho, Li-Hui Lu, Shu-Ling Chen
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Patent number: 7754898Abstract: An asymmetric synthesis of amino acid compound that is useful as a starting material or synthetic intermediate for production of medicinal products, agrichemicals, perfumes, functional polymers, etc. There is provided a method of enanthio-selective nucleophilic addition reaction to imine compound being a method of nucleophilic addition reaction of enamide compound accompanied by amino formation to imino group (—CH?N—) of imine compound, characterized in that the reaction is performed in the presence of a chiral copper catalyst. Further, there is provided a novel method of synthesizing an amino acid compound, etc., to which the above is applied.Type: GrantFiled: January 24, 2005Date of Patent: July 13, 2010Assignee: Japan Science and Technology AgencyInventor: Shu Kobayashi
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Publication number: 20100173993Abstract: A controlled release biocidal salt of a first component comprises a cation of a N?—(C1-C22)alkanoyl di-basic amino acid alkyl(C1-C22)ester cationic biocidal molecule and a second component comprising an anion of a monomeric anionic molecule having insignificant biocidal activity. The salt is characterized such that when the salt is exposed to an aqueous medium, the salt partially dissolves thereby releasing biocidal ions in an amount sufficient to exceed the MIC or MBC of a target bacteria being controlled, and further characterized as leaving a residual reservoir of undissolved salt capable of releasing more biocidal ions as the salt is consumed or otherwise removed from the environment encompassing the target bacteria. The preferred cationic biocidal molecule comprises N?-lauroyl-L-arginine ethyl ester (“LAE”).Type: ApplicationFiled: February 4, 2010Publication date: July 8, 2010Inventors: Anthony J. Sawyer, Richard F. Stockel
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Publication number: 20100152480Abstract: The present invention relates to the methods of synthesizing hydrochloride salt of N-fatty acyl substituted amino acid ethyl ester which comprises a) condensation of aqueous solution of esterified amino acid with an acid halide to obtain an intermediate suspension and b) isolating a hydrochloride salt of N-fatty acylsubstituted amino acid ethyl ester from the intermediate suspension.Type: ApplicationFiled: December 11, 2009Publication date: June 17, 2010Inventor: Ghare Vishwas Sadhu
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Publication number: 20100152447Abstract: A method for preparing compounds of the formula (I) by the cyclization of tetraacetic acid alkyl esters of the formula (II) in the presence of ammonia and formamide as well as to the compounds of the formula (II), which are used in this method.Type: ApplicationFiled: November 23, 2007Publication date: June 17, 2010Applicant: Cyathus Exquirere Pharmaforschungs GmbHInventors: Andreas Koch, Erwin Neufellner
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Publication number: 20100144528Abstract: The present invention provides active ingredients and herbicide formulations, as well as the production processes therefor. The active ingredient of the invention is a dry, solid ammonium salt of glyphosate, having high purity (95 to 100%) and low humidity (<1.0% m/m), and is useful as “technical salt” for the preparation of dry, solid, and water-soluble herbicide formulations of the invention. The production process of said active ingredient comprises a solid/liquid/solid reaction between a solid ammonium salt and solid glyphosate acid, both solid being dispersed in an organic liquid medium. The products of the invention are highly water-soluble and are useful for controlling crop weeds.Type: ApplicationFiled: December 17, 2007Publication date: June 10, 2010Inventor: Ricardo Amaral Remer
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Patent number: 7732558Abstract: A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.Type: GrantFiled: December 27, 2005Date of Patent: June 8, 2010Assignee: Industrial Technology Research InstituteInventors: Abraham Josephk, Hui-Ju Cho, Yu-Hau Shih, Chao-Hung Kao, Huang-Chien Liang
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Publication number: 20100130770Abstract: A method of preparing a N-acyl-N,N?,N?-alkylenediamine trialkanoic acid ester comprising contacting a cyclic amidine with an ester of a haloalkanoic acid is provided. In some embodiments, the method involves preparing a N-acyl-N,N?,N?-ethylenediamine trialkanoic acid ester by contacting a 2-alkyl imidazoline with the ester of haloalkanoic acid. In some embodiments, the N-acyl-N,N?,N?-alkylenediamine trialkanoic acid ester is a synthetic intermediate in the preparation of a N-acyl-N,N?,N?-alkylenediamine trialkanoic acid or a salt thereof. In some embodiments, the method provides novel N-acyl-N,N?,N?-alkylenediamine trialkanoic acids and/or esters, which can be used, for example, as chelating agents.Type: ApplicationFiled: November 12, 2009Publication date: May 27, 2010Inventors: George Petros Yiannikouros, Panos Kalaritis
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Publication number: 20100125138Abstract: The present invention relates generally to processes of making (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione, intermediates thereof, and a process for making a particular polymorph of (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione.Type: ApplicationFiled: November 12, 2009Publication date: May 20, 2010Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: David Paul Provencal, Todd Miller, Yuxin Zhao, Jonathon S. Salsbury
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Publication number: 20100120727Abstract: In one aspect, the present invention provides a composition of a covalent conjugate of an eflornithine analog with an anti-inflammatory drug. In another aspect, the present invention provides a composition of an eflornithine prodrug. In another aspect, the present invention provides a composition of an eflornithine or its derivatives aspirin salt. In another aspect, the present invention provides methods for treating or preventing cancer using the conjugates or salts of eflornithine analogs or eflornithine prodrugs.Type: ApplicationFiled: November 12, 2009Publication date: May 13, 2010Applicant: Kyphia Pharmaceuticals, Inc.Inventor: Feng Xu
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Publication number: 20100095749Abstract: The present invention provides a technique for crystallizing a desired protein at a high probability; namely, a protein crystallizing agent and a method of crystallizing protein. The present invention also provides a technique for determining the conditions for protein crystallization easily with high efficiency; namely, a method of screening the conditions for protein crystallization and a protein crystallization screening reagent. As the protein crystallizing agent, at least one compound selected from the group consisting of a basic amino acid, acidic amino acid, ester derivative of amino acid and amide derivative of amino acid is used, or at least one of these compounds is used in combination with another protein crystallizing agent.Type: ApplicationFiled: September 19, 2007Publication date: April 22, 2010Inventors: Hiroshi Yamaguchi, Len Ito
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Publication number: 20100069544Abstract: Hydrogel contact lens comprising a polymer composition obtainable by polymerising a monomer mixture comprising (a) a betaine ester and (b) an alkyl (meth) acrylate. The hydrogel contact lens has a high affinity for water, high water content and a high water retaining capability and provides a contact lens wearer with a high wearing comfort.Type: ApplicationFiled: November 29, 2007Publication date: March 18, 2010Inventors: Bernardus Franciscus Maria Wanders, Henk Haitjema
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Publication number: 20100056628Abstract: Green and naturally derived biocides such as N?—(C1-C22) alkanoyl di basic amino acid alkyl (C1 to C22) ester salt cationic molecules can be combined with an anionic molecule not generally considered as having significant biocidal activity to provide antimicrobial, antibacterial, and/or antifungal properties with multifunctional benefits including preservative or self-preserving activity.Type: ApplicationFiled: October 19, 2009Publication date: March 4, 2010Inventors: Richard F. Stockel, Anthony Joseph Sawyer
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Publication number: 20100048881Abstract: Provided is an industrially safe and useful azodicarboxylic acid bis(2-alkoxyethyl) ester compound that is useful for the Mitsunobu reaction in which it is used in combination with a phosphorus compound to carry out a dehydration condensation reaction, and also useful as an oxidizing agent, and a starting material for various synthetic processes. Also provided are a production intermediate of the above-described compound, and methods for producing these compounds. An azodicarboxylic acid bis(2-alkoxyethyl) ester compound represented by formula (1); wherein A represents an alkyl group having 1 to 10 carbon atoms.Type: ApplicationFiled: January 30, 2008Publication date: February 25, 2010Applicant: Toyo Kasei Kogyo Co., Ltd.Inventors: Kazutake Hagiya, Takashi Sugimura
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Publication number: 20090326242Abstract: The invention relates to a process for preparing 3-dihalomethylpyrazole-4-carboxylic acid derivatives of the formula (I) by reacting ?-fluoroamines of the formula (III) in the presence of Lewis acids with acrylic acid derivatives of the formula (II) to give vinamidinium salts of the formula (IV) and the subsequent reaction thereof with hydrazines, and to the vinamidinium salts of the formula (IV) themselves.Type: ApplicationFiled: August 22, 2007Publication date: December 31, 2009Applicant: Bayer CropScience AGInventors: Sergi Pazenok, Lui Norbert, Arnd Neeff
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Patent number: 7632836Abstract: The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.Type: GrantFiled: November 28, 2007Date of Patent: December 15, 2009Assignee: CeNeRx Biopharma, Inc.Inventor: Michael Rafferty
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Patent number: 7619050Abstract: The instant invention relates to novel alkoxyamine initiators/regulators containing an ethylenically unsaturated, radically polymerizable group. The compounds are useful for the preparation of complex polymeric architectures. Further aspects of the invention are a polymerizable composition and a polymerization process comprising the alkoxyamine initiators/regulators, a macroinitiator obtainable by said polymerization process and a process for polymerizing with the macroinitiator.Type: GrantFiled: May 17, 2005Date of Patent: November 17, 2009Assignee: Ciba Specialty Chemicals CorporationInventors: Peter Nesvadba, Andreas Kramer, Lucienne Bugnon
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Patent number: 7608621Abstract: The invention described herein relates to certain pyridazinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.Type: GrantFiled: January 11, 2008Date of Patent: October 27, 2009Assignee: SmithKline Beecham, Corp.Inventors: Antony N. Shaw, Kevin J. Duffy, William Henry Miller, Andrea K. Myers, Michael N. Zimmerman
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Publication number: 20090263745Abstract: It is a main object of the present invention to provide a polyimide precursor and a polyimide precursor resin composition, which precursor being easy to synthesize, available at low cost, excellent in storage and capable of giving polyimide that is low in impurities after imidization, irrespective of the chemical structure of the finally-obtained polyimide.Type: ApplicationFiled: March 27, 2009Publication date: October 22, 2009Inventor: Katsuya SAKAYORI
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Publication number: 20090139433Abstract: The present invention relates to an alkylenediamine-N,N,N?,N?-tetraacetic acid-(meth)acrylamide of formula (I) The invention also relates to a polymerizable composition which is characterized in that it comprises at least one alkylenediamine-N,N,N?,N?-tetraacetic acid-(meth)acrylamide of formula (I), and its use in particular as dental material.Type: ApplicationFiled: September 10, 2008Publication date: June 4, 2009Applicant: Ivoclar Vivadent AGInventors: Norbert MOSZNER, Jorg ANGERMANN, Urs Karl FISCHER, Volker M. RHEINBERGER
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Publication number: 20090111813Abstract: The present embodiments are related to the compound of Formula 1 or Formula 2 below and pharmaceutical formulations thereof as well as treatments for a wide variety of Central Nervous System disorders with the pharmaceutical formulations. Some embodiments include the use of a variety of the instant compounds which surprisingly and advantageously exhibit improved pharmacokinetic and therapeutic profiles in comparison to pivagabine.Type: ApplicationFiled: November 28, 2007Publication date: April 30, 2009Applicant: CeNeRx Biopharma, Inc.Inventor: Michael Rafferty
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Publication number: 20090105091Abstract: The present invention provides a compound of the general formula (I), wherein X is the connection between the CO-hydrazine and the NR1-oxalic acid or ester group, and uses and synthesis methods. These compounds represent amino acid derivatives, wherein the amine group is turned into an acidic group by the oxalic acid group and the carboxylic acid is turned into an amine functionality by the hydrazine group; as well as peptidomimetics comprising the compound and methods for their synthesis.Type: ApplicationFiled: November 24, 2006Publication date: April 23, 2009Applicant: TECHNISCHE UNIVERSITAT WIENInventors: Ulrich Jordis, Jaywant B. Phopase
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Publication number: 20090080074Abstract: A polymer film includes: a wavelength dispersion regulator represented by formula (I): wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group or an aryl group, provided that both R1 and R2 are not hydrogen atoms at the same time; and R3 and R4 each independently represents an electron-withdrawing substituent, and R1 and R2, or R3 and R4 may be bonded together to form a ring, and wherein the polymer film has a retardation value that satisfies the following formulae (1) and (2): 70 nm?Rth(548)?300 nm??Formula (1) Rth(628)<Rth(548)<Rth(446)??Formula (2) wherein Rth(?) represents a retardation value expressed in nm in a film thickness direction measured at a wavelength of ? nm.Type: ApplicationFiled: September 4, 2008Publication date: March 26, 2009Applicant: FUJIFILM CorporationInventors: Nobutaka Fukagawa, Masaki Noro, Teruki Niori
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Publication number: 20090047435Abstract: One aspect of the invention is a compound of formula (I) Ro-[L-(CqH2qS)pCrH2rRf]2??(I) wherein Ro is a divalent organic group having 2 to 40 carbon atoms; L is a linking group selected from —NHC(O)NH— or —C(O)NH— wherein the left side of the linking group is bonded to Ro; p is an integer of 0 or 1; q is an integer of 2 to 10; r is an integer of 1 to 10; and Rf is a linear or branched C1-C6 perfluoroalkyl group. Another aspect of the invention is a composite material comprising a porous support and a porous nanoweb, wherein said porous nanoweb comprises fibrous structures of between about 10 nm and about 1000 nm effective average fiber diameter as determined with electron microscopy; said fibrous structures being comprised of one or more compositions of formula (I). Another aspect of the invention is a method for making a composite material comprising a porous support and a porous nanoweb.Type: ApplicationFiled: August 13, 2007Publication date: February 19, 2009Inventors: Keith Ward Hutchenson, Anilkumar Raghavanpillai, Stefan Reinartz
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Patent number: 7488841Abstract: According to the present invention, a process is provided for producing an acyl group-containing composition that includes a step of reacting a long chain N-acyl acidic amino acid anhydride with one or more compounds which have, per molecule, m functional groups of one kind or more selected from the group consisting of hydroxyl, amino and thiol groups in an aqueous solvent and/or a mixed solvent of water and an organic solvent (reaction step). The process makes it possible to produce an acyl group-containing composition that is free from coloration under moderate conditions.Type: GrantFiled: August 26, 2003Date of Patent: February 10, 2009Assignee: Asahi Kasei Chemicals CorporationInventors: Yukio Yamawaki, Takao Kitamura, Yamato Saitou
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Patent number: 7449446Abstract: There is provided a combination product comprising; (A) melagatran or a pharmaceutically acceptable derivative thereof; and (B) dexamethasone or a pharmaceutically acceptable derivative there of, wherein each of components (A) and (B) is formulated in admixture with a pharmaceutically-acceptable adjuvant, diluent or carrier, as well as the use of such a combination product in the treatment of conditions including disseminated intravascular coagulation.Type: GrantFiled: October 24, 2002Date of Patent: November 11, 2008Assignee: AstraZeneca ABInventor: Margareta Elg
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Publication number: 20080249030Abstract: The invention relates to a compound having general formula I, wherein: X represents CH2, C?O, C?S or CHOH, X represents CH2, C?O, C?S or CHOH, R1 represents an amino acid which is optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF3 groups and n=0.1 or 2, or X represents CH2, C?O, C?S, CHOH, R1 represents a peptide containing two amino acids, each amino acid being optionally substituted by one or more halogen atoms, preferably fluorine, or by one or more CF3 groups and n=0 or 1, or XR1 represent PO3H or SO3H and n=0.Type: ApplicationFiled: March 30, 2006Publication date: October 9, 2008Inventors: Pierre Potier, Marie-Claude Denise Michele Zelveyan, Catharine Marie Germaine Magnan
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Patent number: 7425645Abstract: This invention relates to newly identified ester-linked Gemini surfactant compounds of formula (I), where Y is either H or (Aa)x where (Aa) is a basic amino acid and x is 1 to 6, to the use of such compounds and to their production. The invention also relates to the use of the ester-linked Gemini surfactant compounds to facilitate the transfer of polynucleotide into cells.Type: GrantFiled: February 3, 2006Date of Patent: September 16, 2008Assignee: Glaxo Group LimitedInventors: Mariano Javier Castro, Christopher Kitson, Mark Ladlow, Alpesh Patel
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Publication number: 20080207776Abstract: The present invention discloses highly packed polycationic ammonium, sulfonium and phosphonium lipid compounds useful for making lipid aggregates for delivery of macromolecules and other compounds into cells. They are especially useful for the DNA-dependent transformation of cells. Methods for their preparation and use as intracellular delivery agents are also disclosed.Type: ApplicationFiled: October 31, 2007Publication date: August 28, 2008Applicant: INVITROGEN CORPORATIONInventors: Alberto Haces, Valentina C. Ciccarone
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Publication number: 20080171671Abstract: The invention relates to the use of ethoxylated derivatives of amidoamines corresponding to general formula (I): R1—OC—NR2—[(CH2)n—NR3]m—CO—R4 ??(I) In which R1, R2, R3 and R4 independently of one another represent a hydrogen atom, a branched or unbranched alkyl or alkenyl group containing 5 to 23 carbon atoms or a CO—CH=CH—COOH group and n is a number of 1 to 6 and m is a number of 1 to 8, as an emulsifier in drilling fluids which contain at least one continuous oil phase, an aqueous phase and typical additives.Type: ApplicationFiled: October 14, 2005Publication date: July 17, 2008Inventors: Heinz Mueller, Jens Hartmann, Stephan Von Tapavicza, Diana Maeker
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Publication number: 20080161395Abstract: The invention relates to a new class of compounds with action inhibiting carnitine palmitoyl transferase (CPT), pharmaceutical compounds which contain at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic conditions such as diabetes and the pathologies associated with it, congestive heart failure and obesity.Type: ApplicationFiled: February 13, 2006Publication date: July 3, 2008Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Ornella Tinti, Roberto Conti, Natalina Dell'Uomo, Tiziana Brunetti
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Patent number: 7345192Abstract: Compositions including a conjugate of ?-difluoromethylornithine can be applied topically to reduce hair growth.Type: GrantFiled: November 10, 2005Date of Patent: March 18, 2008Assignee: The Gillette CompanyInventors: Anwar Jardien, Roman Rariy, Gurpreet S. Ahluwalia, Douglas Shander
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Publication number: 20080057127Abstract: The present invention relates to compound of formula I, which are functionalized, non-phenolic amino acids, and polymers formed from the same. Polymers formed from the functionalized amino acids are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.Type: ApplicationFiled: August 29, 2007Publication date: March 6, 2008Applicant: BEZWADA BIOMEDICAL, LLCInventor: Rao S. Bezwada
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Patent number: 7279587Abstract: Disclosed is a compound of the formula wherein R1 is an alkylene, arylene, arylalkylene, or alkylarylene group, R2 and R2? each independently of the other, are alkylene, arylene, arylalkylene, or alklarylene groups, R3 and R3? each, independently of the other, are either (a) photoinitiating groups, or (b) groups which are alkyl, aryl, arylalkyl, or alkylaryl groups, provide that at least one of R3 and R3? is a photoinitiating group, and X and X? each, independently of the other, is an oxygen atom or a group of the formula —NR4—, wherein R4 is a hydrogen atom, an alkyl group, an aryl group, or an alkylaryl group.Type: GrantFiled: November 30, 2005Date of Patent: October 9, 2007Assignee: Xerox CorporationInventors: Peter G. Odell, Eniko Toma, Jennifer L. Belelie
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Patent number: 7276614Abstract: Disclosed is a compound of the formula wherein R1 and R1? each, independently of the other, is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or an alkylaryl group having at least one ethylene unsaturation, R2, R2?, and R3 each, independently of the others, are alkylene groups, arylene groups, arylalkylene groups, or alkylarylene groups, and n is an integer representing the number of repeat amide units and is at least 1.Type: GrantFiled: November 30, 2005Date of Patent: October 2, 2007Assignee: Xerox CorporationInventors: Eniko Toma, Peter G. Odell, Adela Goredema, Jennifer L. Belelie
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Patent number: 7271284Abstract: Disclosed is a process for preparing a compound of the formula wherein R1 is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or an alkylaryl group having at least one ethylenic unsaturation, R2 and R3 each, independently of the others, are alkylene groups, arylene groups, arylalkylene groups, or alkylarylene groups, R4 and R5 each, independently of the other, is a hydrogen atom or an alkyl group, and n is an integer representing the number of repeat amide units and is at least 1, said process comprising: (a) reacting a diacid of the formula HOOC—R2—COOH with a diamine of the formula in the presence of a catalyst, a solvent, and a coupling agent to form an oligoamide intermediate; and (b) reacting the oligoamide intermediate with an alcohol of the formula R1—OH to form the product.Type: GrantFiled: November 30, 2005Date of Patent: September 18, 2007Assignee: Xerox CorporationInventors: Eniko Toma, Adela Goredema, Jennifer L. Belelie, Peter G. Odell
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Patent number: 7259275Abstract: Disclosed is a process for preparing a compound of the formula wherein R1 is an alkyl group having at least one ethylenic unsaturation, an arylalkyl group having at least one ethylenic unsaturation, or an alkylaryl group having at least one ethylenic unsaturation, R2 and R3 each, independently of the others, are alkylene groups, arylene groups, arylalkylene groups, or alkylarylene groups, and n is an integer representing the number of repeat amide units and is at least 1, said process comprising: (a) reacting a diacid of the formula HOOC—R2—COOH with a diamine of the formula in the absence of a solvent while removing water from the reaction mixture to form an acid-terminated oligoamide intermediate; and (b) reacting the acid-terminated oligoamide intermediate with a monoalcohol of the formula R1—OH in the presence of a coupling agent and a catalyst to form the product.Type: GrantFiled: November 30, 2005Date of Patent: August 21, 2007Assignee: Xerox CorporationInventors: Jennifer L. Belelie, Adela Goredema, Peter G. Odell, Eniko Toma
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Patent number: 7214813Abstract: Cyclic ?-(acylamino)acrylate derivatives were hydrogenated using Ru-chiral phosphine ligand catalysts and thereafter converted to the corresponding cyclic ?-aminoacids in high yield and enantioselectivity according to the reaction scheme:Type: GrantFiled: May 27, 2004Date of Patent: May 8, 2007Assignee: The Penn State Research FoundationInventors: Xumu Zhang, Wenjun Tang
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Patent number: 7196117Abstract: Antimicrobial system which comprises a cationic surfactant, derived from the condensation of fatty acids and esterified dibasic amino acids, according to the following formula (I), where: X is Br, Cl or HSO4R1: is linear alkyl chain from an saturated fatty acid, or hydroxyacid from 8 to 14 atoms of carbon bonded to the ?-amino acid group through amidic bond. R2 is a linear or branched alkyl chain from 1 to 18 carbon atoms or aromatic. R3: is Formula (II), where n can be from 0 to 4, and at least one antimicrobial agent characterised for its enhanced activity.Type: GrantFiled: November 25, 2001Date of Patent: March 27, 2007Assignee: Laboratorios Miret, S.A.Inventors: Joan Baptista Urgell Beltran, Joan Seguer Bonaventura
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Patent number: 7148371Abstract: The present invention provides a method for industrially producing an optically active lysine derivative useful as a pharmaceutical intermediate. More particularly, the present invention provides a production method including protecting an amino group or an amino group and carboxyl group of optically active 2-amino-6-methyl-6-nitroheptanoic acid with a protecting group, reducing a nitro group to synthesize a 6,6-dimethyl lysine derivative and reacting the 6,6-dimethyl lysine derivative with an acetic acid derivative.Type: GrantFiled: August 26, 2005Date of Patent: December 12, 2006Assignee: Ajinomoto Co., Inc.Inventors: Masakazu Nakazawa, Daisuke Takahashi, Masaki Naito, Kunisuke Izawa