Halogen Or Unsaturation In Acid Moiety Patents (Class 560/172)
  • Patent number: 4243678
    Abstract: Compounds of the formula ##STR1## wherein R is (a) optionally-substituted and optionally-hydrogenated biphenylyl, (b) optionally-substituted and optionally-hydrogenated bicyclic aryl having from 8 to 12 ring carbon atoms or (c) a radical of the formula ##STR2## R.sup.1 is aliphatic hydrocarbyl, alicyclic hydrocarbyl or optionally-substituted phenyl;R.sup.2 is --H or lower aliphatic hydrocarbyl;R.sup.3 is --H, lower alkyl, cycloalkyl, optionally-substituted phenyl or, with R.sup.4, alkylene;R.sup.4 is lower alkyl, cycloalkyl, optionally-substituted phenyl, optionally-(nuclearly)-substituted phenalkyl or, with R.sup.3, alkylene;or R.sup.2,R.sup.3 and R.sup.4, together with the carbon to which each is bound, are adamantyl; andn is 3, 4 or 5;and salts thereof with a base are pharmacologically active. Esters thereof are valuable intermediates for the preparation of the pharmacologically-active compounds. Physiologically-acceptable embodiments are administered, e.g.
    Type: Grant
    Filed: December 15, 1978
    Date of Patent: January 6, 1981
    Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH
    Inventor: Walter Krastinat
  • Patent number: 4237268
    Abstract: Surface-active esters of aliphatic polyols containing at least 3 hydroxyl groups and aliphatic, cycloaliphatic or araliphatic acylaminocarboxylic acids, which contain a total of at least 8, preferably 12-60, carbon atoms and which are acylated by aliphatic carboxylic acids with 1-4 carbon atoms, aromatic or araliphatic carboxylic acids or aliphatic, aromatic or araliphatic sulphonic, carbonic or carbamic acids, are suitable as auxiliaries in the dyeing of textile materials.
    Type: Grant
    Filed: July 18, 1978
    Date of Patent: December 2, 1980
    Assignee: Bayer Aktiengesellschaft
    Inventors: Klaus Walz, Ergun Tamer
  • Patent number: 4228102
    Abstract: What is disclosed is a method for making amides of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.3 is straight-chain or branched alkyl or unsubstituted or substituted aryl, andR.sub.4 is hydrogen or straight-chain or branched unsubstituted or substituted alkyl, which comprises reacting an ester of the formula ##STR2## wherein R.sub.2 is alkyl having 1 to 6 carbon atoms, with heating and under autogenous pressure, in a homogeneous phase, with an amine of the formula ##STR3## said amine being present in an amount which is stoichiometrically deficient up to an amount which is in small stoichiometric excess with respect to said ester.
    Type: Grant
    Filed: February 23, 1979
    Date of Patent: October 14, 1980
    Assignee: Rohm GmbH
    Inventors: Siegmund Besecke, Wolfgang Gaenzler, Guenter Schroeder
  • Patent number: 4209604
    Abstract: Polymerizable acrylic monomers, and anaerobic adhesives which contain such monomers, wherein the acrylic monomers contain internal chain unsaturation in addition to terminal acrylic unsaturation.
    Type: Grant
    Filed: January 7, 1976
    Date of Patent: June 24, 1980
    Assignee: Estech Specialty Chemicals Corporation
    Inventor: Gerhardt P. Werber
  • Patent number: 4201725
    Abstract: Methylamine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein R.sub.1 and R.sub.3 each represent a hydrogen atom or a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 6 carbon atoms, R.sub.2 represents a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 2 to 7 carbon atoms with the proviso that when R.sub.2 represents an alkenyl radical of the formula CH.dbd.CH--R.sub.6 or an alkynyl radical of the formula C.tbd.C--R.sub.6, in which R.sub.6 represents a hydrogen atom or a straight- or branched-chain alkyl radical of 1 to 5 carbon atoms, R.sub.1 and R.sub.3 each represent an atom of hydrogen or an alkyl radical, R.sub.4 and R.sub.5, which are the same or different, each respresent a hydrogen atom, a straight- or branched-chain alkyl, alkenyl or alkynyl radical containing from 1 to 5 carbon atoms or an .omega.-hydroxyalkyl radical containing from 2 to 5 carbon atoms or R.sub.4 and R.sub.
    Type: Grant
    Filed: March 20, 1978
    Date of Patent: May 6, 1980
    Assignee: Labaz
    Inventors: Charles Pigerol, Pierre Eymard, Jean-Claude Vernieres, Jean-Pierre Werbenec, Madeleine C. Epse Broll
  • Patent number: 4201787
    Abstract: Isovaleric acid ester derivatives, process for producing thereof, and insecticides containing said derivatives of the general formula I: ##STR1## wherein A represents O, NH, or CH.sub.2,R.sub.1 represents, if A is O or NH, an alkyl, an alkenyl, a haloalkyl and a haloalkenyl radical with 2-6 carbon atoms, and a radical selected from those of the general formulae II, III, IV and V: ##STR2## in which n is an integer of 1-3, R.sub.3 represents hydrogen, methyl group or chlorine atom; andif A is CH.sub.2, R.sub.1 represents an alkyl, an alkenyl, a haloalkyl and a haloalkenyl radical with 1-5 carbon atoms, whileR.sub.1 --A represents a naphthyl group bonding to the main chain at the .beta.-position, andR.sub.2 represents hydrogen or a cyano group.
    Type: Grant
    Filed: November 30, 1977
    Date of Patent: May 6, 1980
    Assignee: Dainippon Jochugiku Kabushiki Kaisha
    Inventors: Yoshio Katsuda, Yoshihiro Minamite
  • Patent number: 4199345
    Abstract: This disclosure relates to N-trifluoroacetyl-N-phosphonomethylglycine dichloride derivatives and to herbicidal compositions containing same. The N-trifluoroacetyl-N-phosphonomethylglycine dichlorides are useful as post-emergent herbicides.
    Type: Grant
    Filed: October 25, 1978
    Date of Patent: April 22, 1980
    Assignee: Monsanto Company
    Inventor: John E. Franz
  • Patent number: 4180394
    Abstract: This disclosure relates to derivatives of N-trifluoroacetyl-N-phosphonomethylglycinates wherein different moieties are attached to the phosphorus atom, to herbicidal compositions containing same and to the herbicidal use thereof.
    Type: Grant
    Filed: July 10, 1978
    Date of Patent: December 25, 1979
    Assignee: Monsanto Company
    Inventors: John E. Franz, Robert J. Kaufman
  • Patent number: 4159383
    Abstract: N,N-disubstituted acryl- and methacrylamides are disclosed wherein one of the amido nitrogen atom substituents is an n-propionate radical and the other of such substituents is a hydrocarbyl group. The disclosed compounds are useful as comonomers for the preparation of polyvinyl resinous systems in general.
    Type: Grant
    Filed: March 17, 1972
    Date of Patent: June 26, 1979
    Assignee: Sherex Chemical Company, Inc.
    Inventor: Billy M. Culbertson
  • Patent number: 4108861
    Abstract: A compound of the formula ##STR1## wherein R.sub.1 is lower alkyl, aryloxy(lower)alkyl or ar(lower)alkyl,R.sub.2 is lower alkyl,Coor.sub.3 is esterified carboxy selected from lower alkoxycarbonyl and ar(lower)alkoxycarbonyl,X is halogen selected from bromine and chlorine, andX' is hydrogen or halogen selected from bromine and chlorine,Said aryl and said ar each constituting phenyl, tolyl or xylyl, and a method of making it are disclosed.
    Type: Grant
    Filed: March 28, 1977
    Date of Patent: August 22, 1978
    Assignee: Fujisawa Pharmaceutical Co., Ltd.
    Inventors: Yoshito Kishi, Shinichi Nakatsuka, Hideo Tanino
  • Patent number: 4074051
    Abstract: 3-Pyrazolidinone compounds having a solubility of at least 12 grams/liter in an aqueous medium of pH 9 of the formula: ##STR1## wherein R is a mononuclear phenyl group having substituents in the 3, 4, or 5 positions with a total of no more than 4 non-metallic atoms with an atomic number greater than 1 and the total mass of the substituents being less than that of benzene,Q is an aqueous-solubilizing group of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are independently a hydrogen, or alkyl group or together with the included nitrogen form a 5 or 6 membered heterocyclic ring composed of carbon, nitrogen and no more than one atom from the group of sulfur and oxygen, the total number of atoms in R.sup.1 and R.sup.2 having an atomic number greater than 1 being equal to or less than 6.
    Type: Grant
    Filed: November 29, 1973
    Date of Patent: February 14, 1978
    Assignee: Minnesota Mining and Manufacturing Company
    Inventor: John Stevens
  • Patent number: 4054668
    Abstract: Novel N-substituted amino acid derivatives of the formula: ##STR1## wherein R.sub.1 is an alkenyl group having 2 to 5 carbon atoms, a halogen-substituted alkenyl group having 2 to 5 carbon atoms or an alkynyl group having 2 to 5 carbon atoms, R.sub.2 is a methyl or ##STR2## group in which R.sub.2 ' is an alkyl group having 1 to 4 carbon atoms or a halogen-substituted alkyl group having 1 to 4 carbon atoms; and R.sub.3 is a hydrogen atom, an alkyl having 1 to 20 carbon atoms, cycloalkyl having 3 to 6 carbon atoms, benzyl, hydroxyethyl or methoxyethyl group, and inorganic or organic acid addition salts thereof, which possess useful soil fungicidal activities and can be produced by reacting a sarcosine derivative of the formula:CH.sub.3 HNCH.sub.2 COOR.sub.3 (II)wherein R.sub.3 is as defined above, with a halogen compound of the formula:R.sub.1 -- X (III)wherein R.sub.1 is as defined above and X is a halogen atom, or by reacting an N-substituted glycine derivative of the formula: ##STR3## wherein R.sub.1 and R.
    Type: Grant
    Filed: October 2, 1975
    Date of Patent: October 18, 1977
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Osamu Kirino, Tadashi Ooishi, Nobuyuki Kameda, Toshiro Kato, Akira Fujinami, Toshiaki Ozaki
  • Patent number: 4046803
    Abstract: A method for the preparation of .beta.-amino derivatives of .alpha.,.beta.-unsaturated esters of the formula CH.sub.3 C(NH.sub.2)=CHCOOR' where R' is C.sub.1 to C.sub.10 linear or branched alkyl or substituted C.sub.1 to C.sub.10 linear or branched alkyl. A reaction mixture of an acetoacetate ester of the formula CH.sub.3 C(O)CH.sub.2 C(O)OR' wherein R' is the same as defined above is first formed in an organic solvent and this mixture reacted with aqueous ammonium hydroxide in the presence of a salt of ammonia or of a metal selected from the group consisting of lithium, zinc, cadmium, cerium and lead. The salt is soluble in the organic solvent to an extent sufficient to catalyze the reaction between ammonia and the ester.
    Type: Grant
    Filed: October 27, 1976
    Date of Patent: September 6, 1977
    Assignee: Armstrong Cork Company
    Inventor: John S. Heckles