Polyoxy Acid Moiety Patents (Class 560/186)
  • Patent number: 10474030
    Abstract: A resist composition comprising a base polymer and a metal salt of carboxylic acid or sulfonamide is provided, the metal being selected from calcium, strontium, barium, cerium, aluminum, indium, gallium, thallium scandium, and yttrium. The resist composition exhibits a sensitizing effect and an acid diffusion suppressing effect and forms a pattern having improved resolution, LWR and CDU.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: November 12, 2019
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Jun Hatakeyama, Masaki Ohashi, Takeshi Sasami
  • Publication number: 20150072028
    Abstract: The present invention relates to extracts, compounds isolated from Cakile arabica for use in the treatment of ulcer and to pharmaceutical compositions thereof.
    Type: Application
    Filed: September 4, 2014
    Publication date: March 12, 2015
    Applicant: KING SAUD UNIVERSITY
    Inventors: Awaad Amani SHAFEEK, Reham Moustafa EL-MELIGY, Mohammed Sobhy MARZOUK, Shroog Mohamed ALOTAIBY
  • Publication number: 20140316157
    Abstract: The invention relates to etherified lactate esters of formula (I), in which R represents alkyl and RI an alkoxylated alkyl radical and to the use thereof for enhancing the effect of plant protecting agents.
    Type: Application
    Filed: July 23, 2012
    Publication date: October 23, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Peter Baur, Klaus Lorenz, Jörg Hofmann
  • Patent number: 8829229
    Abstract: New polyol ether compounds and a process for their preparation. The process comprises reacting a polyol, a carbonyl compound, and hydrogen in the presence of hydrogenation catalyst, to provide the polyol ether. The molar ratio of polyol to carbonyl compound in the process is greater than 5:1.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: September 9, 2014
    Assignee: Dow Global Technologies LLC
    Inventors: Michael L. Tulchinsky, John R. Briggs, Cynthia L. Rand
  • Publication number: 20140120058
    Abstract: The present invention relates in general to polymer-drug conjugates. In particular, the invention relates to polymer-drug conjugates wherein the conjugated drugs are selected from prostaglandins and substituted prostaglandins, to a method of delivering such prostaglandin drugs to a subject, to a sustained drug delivery system comprising the polymer-drug conjugates, to a method of preparing the polymer-drug conjugates, and to an implant comprising the polymer-drug conjugates. The polymer-drug conjugates may be useful for delivering prostaglandins and substituted prostaglandins for the treatment of glaucoma.
    Type: Application
    Filed: April 12, 2012
    Publication date: May 1, 2014
    Inventors: Michael Shane O'Shea, Florian Hans Maximillian Graichen, Russell John Tait, Andrew Craig Donohue, Sarah Man Yee Ng, Asha Marina D'Souza
  • Patent number: 8653131
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: February 18, 2014
    Assignees: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Guohan Yang, Ton That Hai, Bennett P. Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • Publication number: 20130190523
    Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates firmed thereby.
    Type: Application
    Filed: March 12, 2013
    Publication date: July 25, 2013
    Applicant: Vascular Biogenics Ltd.
    Inventor: Vascular Biogenics Ltd.
  • Publication number: 20130158283
    Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
    Type: Application
    Filed: December 10, 2012
    Publication date: June 20, 2013
    Applicant: Vascular Biogenics Ltd.
    Inventor: Vascular Biogenics Ltd.
  • Publication number: 20130096322
    Abstract: A method of production of value-added, biobased chemicals, derivative products, and/or purified glycerin from bioglycerin of recycled oil, grease, and/or fat origin is described herein. A method of purification of bioglycerin of recycled oil, grease, and/or fat origin is also described herein. The method of purification of bioglycerin of recycled oil, grease, and/or fat origin described provides methods for desalinating, decolorizing, and/or concentrating bioglycerin of recycled oil, grease, and/or fat origin for the production of biobased chemicals, derivative products, and/or purified glycerin.
    Type: Application
    Filed: January 12, 2012
    Publication date: April 18, 2013
    Applicant: THESIS CHEMISTRY, LLC
    Inventors: John R. Peterson, Christopher M. Yost
  • Patent number: 8420109
    Abstract: The present invention provides an oily base for a cosmetic comprising an ester compound made from a multivalent alcohol and a fatty acid, characterized in that the ester compound is made from dipentaerythritol and at least one fatty acid selected from the group consisting of fatty acids having 5 to 16 carbon atoms and a molar ratio of a dipentaerythritol residue to a fatty acid residue having 5 to 16 carbon atoms in the ester compound is 1.0:3.0 to 1.0:6.0. The aforesaid oily base for a cosmetic has proper oily feeling with moistness, no uncomfortable sticky feeling, excellent safety to the skin and adhesion to the skin, excellent gloss-holding ability after application to the skin, and excellent compatibility with various oil agents. In addition, upon blending the ester compound in various cosmetics, the cosmetics also have proper emollient property.
    Type: Grant
    Filed: August 5, 2010
    Date of Patent: April 16, 2013
    Assignee: Kokyo Alcohol Kogyo Co., Ltd.
    Inventors: Naoki Sasaki, Yuki Kokeguchi, Kiyotaka Kawai
  • Patent number: 8357736
    Abstract: A defoaming agent which can effectively eliminate foams generated in the occasions of preparation, coating, drying and baking of water-based paint, by addition thereof by itself, without combined use of other kind(s) of defoaming agent(s), and furthermore without impairing appearance of baked coated film of the paint or recoatability of the paint is provided. Such a defoaming agent for water-based paint has the composition comprising (1) polyoxyethylene hydrogenated castor oil triisostearates and (2) polyalkyl vinyl ether, polybutadiene, polybutene or polyisoprene, which are dissolved in (3) liquid normal paraffin, liquid isoparaffin or liquid cycloparaffin, at such a ratio that the blended amount of (1) occupies 2-90% by weight of the total composition.
    Type: Grant
    Filed: February 1, 2012
    Date of Patent: January 22, 2013
    Assignee: Kusumoto Chemicals, Ltd.
    Inventors: Tomoko Arima, Takashi Horiguchi, Shigehiro Kawahito
  • Patent number: 8299293
    Abstract: A method for preparing ?-keto acids, especially ?-ketomethionine, and/or derivatives thereof, whereby an aldehyde is reacted with thiols to give a corresponding dithioacetal, the dithioacetal formed, is reacted with an electrophile in the presence of a strong base, and the resulting ?,?-(dithio)carboxylic acid is solvolyzed with acid-catalysis to release thiol and give the ?-keto acid or a derivative thereof. Umpolung of aliphatic or aromatic aldehydes is effected by reaction with thiols.
    Type: Grant
    Filed: July 9, 2008
    Date of Patent: October 30, 2012
    Assignee: Evonik Degussa GmbH
    Inventors: Christoph Kobler, Martin Hateley, Philipp Roth, Barbara Jaeger, Christoph Weckbecker, Klaus Huthmacher
  • Publication number: 20120095254
    Abstract: The invention provides a novel apparatus and method for preparing a solution of a shear sensitive material.
    Type: Application
    Filed: December 22, 2011
    Publication date: April 19, 2012
    Inventors: Royal D. Hathaway, JR., Joseph R. Sclafani, JR.
  • Patent number: 8143325
    Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more
    Type: Grant
    Filed: June 25, 2010
    Date of Patent: March 27, 2012
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S. Bezwada
  • Patent number: 8133945
    Abstract: A defoaming agent which can effectively eliminate foams generated in the occasions of preparation, coating, drying and baking of water-based paint, by addition thereof by itself, without combined use of other kind(s) of defoaming agent(s), and furthermore without impairing appearance of baked coated film of the paint or recoatability of the paint is provided. Such a defoaming agent for water-based paint has the composition comprising (1) polyoxyethylene hydrogenated castor oil triisostearates and (2) polyalkyl vinyl ether, polybutadiene, polybutene or polyisoprene, which are dissolved in (3) liquid normal paraffin, liquid isoparaffin or liquid cycloparaffin, at such a ratio that the blended amount of (1) occupies 2-90% by weight of the total composition.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: March 13, 2012
    Assignee: Kusumoto Chemicals, Ltd.
    Inventors: Tomoko Arima, Takashi Horiguchi, Shigehiro Kawahito
  • Patent number: 8124800
    Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
    Type: Grant
    Filed: August 24, 2010
    Date of Patent: February 28, 2012
    Assignee: Vascular Biogenics Ltd.
    Inventors: Gideon Halperin, Eti Kovalevski-Ishai
  • Publication number: 20120004385
    Abstract: Disclosed is a maintenance liquid for property carrying out imprints excellent in patternability. The maintenance liquid for imprints of an ink-jet discharging device comprises a compound comprising an ester group and/or an ether group.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 5, 2012
    Applicant: FUJIFILM CORPORATION
    Inventors: Kunihiko KODAMA, Kenichi KODAMA
  • Publication number: 20110237770
    Abstract: The present invention relates to a process for the preparation of a polyurethane, comprising the process steps: i) provision of a polyisocyanate component comprising at least one polyisocyanate; ii) provision of a polyol component comprising at least one polyether polyol, one polyester polyol or a mixture of a polyether polyol and a polyester polyol, wherein the polyol component comprises a polyol ester of a polyol and a monocarboxylic acid; iii) bringing of the polyisocyanate component into contact with the polyol component to form a polyurethane.
    Type: Application
    Filed: August 28, 2009
    Publication date: September 29, 2011
    Inventors: Peter Daute, Bernhard Bartnick
  • Publication number: 20110217245
    Abstract: The present invention is related to substituted butanol derivatives of the formula: wherein R is an unsubstituted or substituted C1-6 straight chain alkyl, an unsubstituted or substituted C3-6 branched chain alkyl, an unsubstituted or substituted C3-6 straight chain alkenyl, an unsubstituted or substituted C3-6 branched chain alkenyl, an unsubstituted or substituted C3-6 cycloalkyl, an unsubstituted or substituted C1-6 alkoxy, nitrile, halo, amino, an unsubstituted or substituted C1-6 alkylamino, an unsubstituted or substituted C1-6 dialkylamino, carboxy-C1-6 alkylamino, carboxy-C1-6 dialkylamino, an unsubstituted or substituted acetoxy, carboxy, an unsubstituted or substituted carboxyethyl, an unsubstituted or substituted C1-6 alkylcarbonyl, an unsubstituted or substituted C1-6 alkylcarboxy, an unsubstituted or substituted C1-6 alkylthio, an unsubstituted or substituted C1-6 alkyloxy, carboxamido, an unsubstituted or substituted C1-6 alkylcarboxamido or an unsubstituted or substituted C1-6 dialkylcarboxa
    Type: Application
    Filed: December 30, 2010
    Publication date: September 8, 2011
    Inventors: Frank Derosa, Michael E. Lankin, Andrew T. Lupo, JR.
  • Publication number: 20110184207
    Abstract: A new method for fabricating glycol monoalkyl ether acetate (GMAEA) is provided. A Bronsted acidic ionic liquid is used. After some reactions, two layers of materials are formed. A product of GMAEA is obtained at the upper layer. The lower layer is the ionic liquid. Thus, the ionic liquid is reusable for re-fabricating the product. And, furthermore, waste acid is reduced.
    Type: Application
    Filed: May 17, 2010
    Publication date: July 28, 2011
    Applicant: CPC CORPORATION
    Inventors: Jung-Chung Wu, Ming-Yu Huang, Jen-Chun Chang, Jann-Chen Lin
  • Publication number: 20110082200
    Abstract: Compositions containing 5,6,7-trihydroxyheptanoic acid and analogs and their use for treating posterior segment ocular diseases and diseases characterized by cellular hyperproliferation or angiogenesis, are disclosed.
    Type: Application
    Filed: December 14, 2010
    Publication date: April 7, 2011
    Applicant: ALCON, INC.
    Inventors: Peter G. KLIMKO, Mark R. HELLBERG, David P. BINGAMAN, Daviel A. GAMACHE
  • Patent number: 7888083
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: February 15, 2011
    Assignee: AstraZeneca UK Limited
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Publication number: 20110034723
    Abstract: The present invention provides an oily base for a cosmetic comprising an ester compound made from a multivalent alcohol and a fatty acid, characterized in that the ester compound is made from dipentaerythritol and at least one fatty acid selected from the group consisting of fatty acids having 5 to 16 carbon atoms and a molar ratio of a dipentaerythritol residue to a fatty acid residue having 5 to 16 carbon atoms in the ester compound is 1.0:3.0 to 1.0:6.0. The aforesaid oily base for a cosmetic has proper oily feeling with moistness, no uncomfortable sticky feeling, excellent safety to the skin and adhesion to the skin, excellent gloss-holding ability after application to the skin, and excellent compatibility with various oil agents. In addition, upon blending the ester compound in various cosmetics, the cosmetics also have proper emollient property.
    Type: Application
    Filed: August 5, 2010
    Publication date: February 10, 2011
    Inventors: Naoki Sasaki, Yuki Kokeguchi, Kiyotaka Kawai
  • Publication number: 20110021680
    Abstract: Triglyceride and other polyol ester PVC plasticizers can be produced by recovery of branched C6 to C9 aldehydes from a hydroformylation product, optional hydrogenation to the alcohol, oxidation to the acid with oxygen and/or air, recovery of the resulting acid, and esterification with glycerol, ethylene glycol, propylene glycol or mixtures thereof. The branched alkyl chains comprise at least 10% methyl branching. Special triglycerides are derived from branched aliphatic acids having alkyl chains with average carbon numbers from 6 to 9 and at least 10% methyl branching. These triglycerides are fast fusing plasticisers if before esterification with glycerol, an aryl acid is introduced together with the aliphatic acids.
    Type: Application
    Filed: March 18, 2009
    Publication date: January 27, 2011
    Inventors: Karla S. Colle, Phillippe Louis Buess, Eddy Theophile Van Driessche, Allen D. Godwin, Ramzi Yanni Saleh, Jon E.R. Stanat, Raphael Frans Caers
  • Patent number: 7858821
    Abstract: The present invention relates to intermediates useful in the synthesis of Dolasetron and synthetic precursors thereof, as well as to processes for obtaining them. In addition, it refers to the hydrochloric salt of Dolasetron and polymorphic forms of Dolasetron and precursors thereof.
    Type: Grant
    Filed: January 22, 2008
    Date of Patent: December 28, 2010
    Assignee: INKE, S.A.
    Inventors: Juan Antonio Pérez Andrés, Pere Dalmases Barjoan, Joan Huguet Clotet
  • Publication number: 20100317886
    Abstract: All labeled carbons are derived ultimately from CO, as carbon-13 is separated from its lighter isotope by cyrogenic distillation of carbon monoxide (CO). Creation of stereospecific and site-specific compounds used for starting materials will address growing demands for labeled compounds, including isotopically-labeled functionalized dienes. Functionalized diene compounds can be used as precursors for the production of isotopically labeled pharmaceuticals, biomolecules, and natural products.
    Type: Application
    Filed: June 11, 2010
    Publication date: December 16, 2010
    Inventor: Rodolfo A. Martinez
  • Publication number: 20100317881
    Abstract: Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed. Further disclosed are novel methods of introducing phosphorous-containing moieties such as phosphate moieties to compounds having glycerolic backbone and intermediates formed thereby.
    Type: Application
    Filed: August 24, 2010
    Publication date: December 16, 2010
    Applicant: Vascular Biogenics Ltd.
    Inventors: Gideon HALPERIN, Eti Kovalevski-Ishai
  • Publication number: 20100227865
    Abstract: The invention provides Beta-blocker drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the Beta-blocker drug not attached to the water soluble oligomer.
    Type: Application
    Filed: March 12, 2008
    Publication date: September 9, 2010
    Inventors: Jennifer Riggs-Sauthier, Franco J. Duarte, Aaron S. Hammons
  • Publication number: 20100217031
    Abstract: The present invention relates to a continuous process for preparing alkyl 3,3-dialkoxy-propionates of the formula (RO)2CHCH2CO2R, wherein R is C1-6 alkyl, by reacting ketene with an ortho formate of formula (RO)3CH in the presence of an acidic catalyst, characterized in that the reaction is carried out in a loop reactor.
    Type: Application
    Filed: October 29, 2008
    Publication date: August 26, 2010
    Inventors: Wolfgang Wenger, Cornelia Zur Täschler, Daniel Zollinger
  • Publication number: 20100209723
    Abstract: There is provided a novel crosslinking agent for use in crosslinked polymer fabrication, specifically a crosslinking agent containing at least one compound selected from glyoxylate and a glyoxylic acid ester derivative represented by the following general formula (1): wherein R1 and R2 each independently represents an alkyl group having 1 to 10 carbon atoms and R3 represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
    Type: Application
    Filed: August 29, 2008
    Publication date: August 19, 2010
    Applicant: THE NIPPON SYNTHETIC CHEMICAL INDUSTRY CO., LTD.
    Inventors: Shinichi Tanaka, Hideki Kageyama, Hiroyuki Ono, Akiko Kuruma
  • Patent number: 7772352
    Abstract: Absorbable polyurethanes, polyamides and polyester urethanes prepared from at least one compound selected from: or the diamines and diisocyanates thereof, wherein each X represents a member independently selected from —CH2COO— (glycolic acid moiety), —CH(CH3)COO— (lactic acid moiety), —CH2CH2OCH2COO— (dioxanone), —CH2CH2CH2CH2CH2COO— (caprolactone moiety), —(CH2)yCOO— where y is one of the numbers 2, 3, 4 or 6-24 inclusive, and —(CH2CH2O)z?CH2COO— where z? is an integer between 2 and 24, inclusive; each Y represents a member independently selected from —COCH2O— (glycolic ester moiety), —COCH(CH3)O— (lactic ester moiety), —COCH2OCH2CH2O— (dioxanone ester), —COCH2CH2CH2CH2CH2O— (caprolactone ester), —CO(CH2)mO— where m is an integer between 2, 3, 4 or 6-24 inclusive, —COCH2O(CH2CH2O)n— where n is an integer between 2 and 24, inclusive; R? is hydrogen, benzyl or an alkyl group, the alkyl group being either straight-chained or branched; p is an integer between 1 and 4, inclusive; and Rn represents one or more
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: August 10, 2010
    Assignee: Bezwada Biomedical LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20100172996
    Abstract: Disclosed is a chain-end functionalized methoxy poly(ethylene glycol) (mPEG), a process of preparing the same, a living methoxy poly(ethylene glycol) for preparing the functionalized methoxy poly(ethylene glycol), a nano-particles of transition metal or metal salt encapsulated in the micelle structure formed by the chain-end functionalized methoxy poly(ethylene glycol), and a method for preparing the nano-particles of transition metal or metal salt.
    Type: Application
    Filed: May 29, 2008
    Publication date: July 8, 2010
    Applicant: Youl Chon Chemical Co., Ltd.
    Inventors: Dong-Youn Shin, Ji Hee Kim
  • Patent number: 7732171
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Grant
    Filed: July 23, 2008
    Date of Patent: June 8, 2010
    Assignee: AstraZeneca UK Limited
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Publication number: 20100123269
    Abstract: A photosensitive resin composition and a method for forming an organic film on a substrate are provided. Because the photosensitive resin composition for imprinting includes an erythrotol-based monomer or oligomer, an organic film formed by the photosensitive resin composition for imprinting has improved restoring force. Therefore, the photosensitive resin composition is appropriate for imprinting processes.
    Type: Application
    Filed: November 12, 2009
    Publication date: May 20, 2010
    Inventors: Yeon Heui NAM, Jin Wuk Kim, Tae Joon Song, Seong Pil Cho, Byung Uk Kim, Seung Hyup Shin, Jun Yong Song, Myoung Soo Lee
  • Publication number: 20100117022
    Abstract: A polyol ester suitable for use as a lubricant or a lubricant base stock has a kinematic viscosity at 40° C. less than or equal to 22 cSt and a viscosity index of greater than or equal to 140. The ester comprises a reaction product of (a) at least one polyhydric alcohol having at least 2 primary hydroxyl groups, (b) at least one monocarboxylic acid having 2 to 15 carbon atoms and (c) at least one polycarboxylic acid having 2 to 15 carbon atoms, wherein the number of acid groups derived from the polycarboxylic acid(s) is at least 25% of the total number of acid groups derived from the monocarboxylic and polycarboxylic acids.
    Type: Application
    Filed: October 8, 2009
    Publication date: May 13, 2010
    Applicant: CHEMTURA CORPORATION
    Inventors: Dale Carr, Jeffrey Hutter, Edward T. Hessell, Richard Kelley
  • Publication number: 20100099788
    Abstract: The present invention relates to a process for the preparation of polyether ester polyols starting from fatty acid esters and starter compounds having Zerewitinoff-active hydrogen atoms, and to their use in the production of solid or foamed polyurethane materials.
    Type: Application
    Filed: October 15, 2009
    Publication date: April 22, 2010
    Applicant: Bayer MaterialScience AG
    Inventors: Klaus Lorenz, Reinhard Albers, Frank Otto
  • Publication number: 20100093757
    Abstract: A compound of Formula (I): is useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK or GK), leading to a decreased glucose threshold for insulin secretion.
    Type: Application
    Filed: August 4, 2009
    Publication date: April 15, 2010
    Applicant: AstraZeneca AB
    Inventors: Stuart Norman Lile BENNETT, Roger John Butlin, Leonie Campbell, Robert Darren Morse Davies, Graeme Richard Robb, Rolf Peter Walker, Michael James Waring, Helen Claire Pointon, Mikael Dan Brink, Jonas Rickard Fägerhag, Ulrik Jurva, Volker Schnecke, Anette Marie Svensson Henriksson, Christer Ralf Westerlund, Peter Gustaf Bonn
  • Publication number: 20100048483
    Abstract: The present invention relates to polymeric derivatives, which can be conjugated to an amino-containing drug to improve its in vivo properties. The polymeric derivative can subsequently be released to yield the drug in its native form. Methods of preparing and using these polymeric derivatives and drug conjugates are described.
    Type: Application
    Filed: August 21, 2009
    Publication date: February 25, 2010
    Applicants: BAXTER HEALTHCARE S.A., BAXTER INTERNATIONAL INC.
    Inventors: Guohan Yang, Ton T. Hai, Bennett Melnick, Paul Sanders, Cong Jiang, Catherine Quinn, Jie Li, Arounaguiry Ambroise, Larry R. Brown
  • Publication number: 20100048940
    Abstract: New polyol ether compounds and a process for their preparation. The process comprises reacting a polyol, a carbonyl compound, and hydrogen in the presence of hydrogenation catalyst, to provide the polyol ether. The molar ratio of polyol to carbonyl compound in the process is greater than 5:1.
    Type: Application
    Filed: August 19, 2009
    Publication date: February 25, 2010
    Inventors: Michael L. Tulchinsky, John R. Briggs, Cynthia L. Rand
  • Patent number: 7662861
    Abstract: The present invention provides compositions and methods for administering florfenicol to mammals. The compositions contain a prodrug of florfenicol in a pharmaceutically acceptable carrier. In one embodiment the prodrug is an esterized form of florfenicol. Examples of suitable prodrugs include one or a combination of one or a combination of the following: florfenicol acetate, florfenicol propionate, florfenicol butyrate, florfenicol pentanoate, florfenicol hexanoate, florfenicol heptanoate, florfenicol octanoate, florfenicol nanoate, florfenicol decanoate, florfenicol undecanoate, florfenicol dodecanoate, and florfenicol phthalate. In another embodiment the prodrug is converted into the florfenicol in vivo by the action of one or more endogenous esterases. The invention also provides new compounds, pharmaceutical compositions containing the compounds, and methods for their administration.
    Type: Grant
    Filed: January 31, 2007
    Date of Patent: February 16, 2010
    Assignee: IDEXX Laboratories, Inc.
    Inventors: Yerramilli V. S. N. Murthy, Robert H. Suva
  • Patent number: 7550617
    Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: June 23, 2009
    Assignees: Medical College of Georgia Research Institute, Board of Regents, The University of Texas System
    Inventors: John D. Imig, John R. Falck
  • Patent number: 7550625
    Abstract: The invention relates to compounds of formula (I): wherein R is —C(O)CH2OCH2CH2OCH3 or —C(O)CH2N(CH3)2. The invention also relates to pharmaceutical compositions comprising a compound formula (I) and methods of treating or preventing a condition in an animal comprising administering to an animal in need thereof a compound of formula (I).
    Type: Grant
    Filed: October 13, 2008
    Date of Patent: June 23, 2009
    Assignee: IDEXX Laboratories
    Inventor: Yerramilli V. S. N. Murthy
  • Patent number: 7531688
    Abstract: A method for making fatty acid esters by reacting triglycerides with an excess of alcohol in a pressurized environment, where the unreacted alcohol component is separated from the reaction product by a flash purification techniques. In this manner, the pressure of the product stream is significantly reduced to vaporize unreacted alcohol, which is then condensed for later reuse. The invention provides a cost-effective and convenient mechanism to simultaneously recycle excess alcohol and to purify ester product and/or glycerol product streams.
    Type: Grant
    Filed: June 12, 2007
    Date of Patent: May 12, 2009
    Assignee: Orbitek, Inc.
    Inventor: Christian A. Fleisher
  • Publication number: 20080312468
    Abstract: A method for making fatty acid esters by reacting triglycerides with an excess of alcohol in a pressurized environment, where the unreacted alcohol component is separated from the reaction product by a flash purification techniques. In this manner, the pressure of the product stream is significantly reduced to vaporize unreacted alcohol, which is then condensed for later reuse. The invention provides a cost-effective and convenient mechanism to simultaneously recycle excess alcohol and to purify ester product and/or glycerol product streams.
    Type: Application
    Filed: June 12, 2007
    Publication date: December 18, 2008
    Inventor: Christian A. Fleisher
  • Publication number: 20080249306
    Abstract: The present invention relates to a process for the production of statins, which are known as HMG-CoA reductase inhibitors. A few of the intermediate compounds for use in the process in accordance with the invention are novel compounds and the invention also relates to these novel intermediate compounds.
    Type: Application
    Filed: April 28, 2006
    Publication date: October 9, 2008
    Inventors: Vitali Tararov, Armin Boerner, Gerd Koenig, Andrei Korostylev
  • Patent number: 7416865
    Abstract: A process is provided for the preparation of a compound of formula (1) wherein R and R? represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
    Type: Grant
    Filed: April 27, 2006
    Date of Patent: August 26, 2008
    Assignee: AstraZeneca UK Limited
    Inventors: Andrew John Blacker, Christopher David Reeve, Robert Antony Holt
  • Publication number: 20080146663
    Abstract: Derivative compounds of 11-nonyloxy-undec-8(Z)-eonic acid that mimic epoxide metabolites are provided. Also provided are compositions comprising a therapeutically effective amount of the derivative compounds. The present invention further provides methods for the use of such compositions for the treatment of renal or cardiovascular disease and/or related conditions.
    Type: Application
    Filed: October 2, 2007
    Publication date: June 19, 2008
    Inventors: John D. Imig, John R. Falck
  • Publication number: 20080114185
    Abstract: A method for producing an unsaturated vicinal diol compound represented by the formula (2): wherein R1, R2, R3, R4, R5 and R are the same or different and each independently represent a hydrogen atom; a C1-C20 alkyl group which may be substituted with a halogen atom or atoms, a C1-C6 alkoxy group or groups, a C2-C7 alkoxycabonyl group or groups, a C6-C10 aryl group or groups, or a carboxyl group or groups; or a C6-C10 aryl group which may be substituted with a halogen atom or atoms, a C1-C6 alkoxy group or groups, a C6-C10 aryl group or groups, or a carboxyl group or groups; which comprises reacting an unsaturated epoxy compound represented by the formula (1): wherein R1, R2, R3, R4, R5 and R6 are the same as defined above, with water in the presence of a silicate containing at least one element selected from a group 5 element and a group 6 element of the long periodic table as a constituent.
    Type: Application
    Filed: September 9, 2005
    Publication date: May 15, 2008
    Applicant: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Koji Hagiya
  • Patent number: 7321059
    Abstract: Compounds of formula (I): or salts or solvate thereof, wherein: n and N independently represent an integer 2 to 12; m1 and m2 independently represent an integer 1 to 15; and R1 and R2 independently represent —(CO)xC1-9 alkyl or —(CO)xC1-9 fluoroalkyl, which fluoroalkyl moiety contains at least 1 fluorine atom and not more than 3 consecutive perfluorocarbon atoms wherein x represents 0 or 1, as well as pharmaceutical formulations containing such compounds and processes for the manufacture of such compounds are disclosed. Intermediates of such compounds and processes for the manufacture of such intermediates are also disclosed.
    Type: Grant
    Filed: October 17, 2002
    Date of Patent: January 22, 2008
    Assignee: Glaxo Group Limited
    Inventors: Brian Edgar Looker, Christopher James Lunniss, Alison Judith Redgrave
  • Patent number: 7169950
    Abstract: The invention relates to a method for producing monocarbonyl compounds or biscarbonyl compounds or hydroxyl compounds by ozonizing, unsaturated organic carbon compounds that, per molecule, have one or more olefinic or aromatic double bonds, which can be cleaved by ozone, and by subsequently processing the ozonization products.
    Type: Grant
    Filed: February 13, 2002
    Date of Patent: January 30, 2007
    Assignee: DSM Fine Chemicals Austria NFG GmbH & Co KG
    Inventors: Alexander Sajtos, Engelbert Kloimstein, Curt Zimmermann