Nor-a Ring Patents (Class 560/258)
  • Patent number: 8461327
    Abstract: The present invention relates to a salt of a carboxylic acid with a diamine such as 2,2?-(ethylenedioxy)diethyl amine, 3,3?-(ethylenedioxy)dipropyl amine and 2,2?-oxybis(ethylamine) and a method of preparing such salts. Preferably the carboxylic acid is a fermentation product such as clavulanic acid, mycophenolic acid or pravastatin.
    Type: Grant
    Filed: March 31, 2009
    Date of Patent: June 11, 2013
    Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.
    Inventors: Robertus Mattheus De Pater, Adrianus Antonius Cornelius Van Wijk, Piotr Wnukowski
  • Patent number: 7186756
    Abstract: Steroids of the formula wherein R is defined as in the application capable of increasing the synthesis of collagen.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: March 6, 2007
    Assignee: Inovat
    Inventors: Gilles Gutierrez, Mostafa Serrar, Zohra Hadid
  • Publication number: 20020173668
    Abstract: Diels-Alder adducts of dienophiles such as epoxybutene with dienes such as cyclopentadiene and cyclohexadiene are produced by carrying out the Diels-Alder reaction thereof at an elevated pressure. Addional dienophiles disclosed include 2,5-dihydrofuran and derivatives thereof; Additional dienes include isoprene and butadiene. Compounds produced from such reactions are also disclosed.
    Type: Application
    Filed: February 8, 2002
    Publication date: November 21, 2002
    Inventors: Mark E. Welker, Marion A. Franks
  • Publication number: 20020082295
    Abstract: The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high purity. The process includes the stages of forming an solution of the compound by extraction, obtaining an ammonium salt of pravastatin from the solution, purifying the ammonium salt of the compound and transposing the salt of the compound to pravastatin sodium.
    Type: Application
    Filed: October 5, 2001
    Publication date: June 27, 2002
    Inventors: Vilmos Keri, Lajos Deak, Ilona Forgacs, Csaba Szabo, Arvai Edit Nagyne
  • Patent number: 4661149
    Abstract: The invention relates to certain substituted phenoxypropionaldehyde derivatives, formulations of said derivatives and the use thereof for preemergence or postemergence control of noxious plants, i.e., weeds.
    Type: Grant
    Filed: November 12, 1985
    Date of Patent: April 28, 1987
    Assignee: PPG Industries, Inc.
    Inventor: Muppala S. Raju
  • Patent number: 4309565
    Abstract: The present invention is directed to a process for synthesizing A-nor and A-nor-18-homo-steroids. The invention is concerned with providing a total synthesis for the compounds called Dinordin and 18-homo-Dinordin. The preparation of other compounds will also be evident.
    Type: Grant
    Filed: April 15, 1980
    Date of Patent: January 5, 1982
    Assignee: World Health Organization
    Inventor: Pierre Crabbe
  • Patent number: 4129599
    Abstract: Method is provided for cyclization of polyunsaturated substituted acylic or monocarbocyclic initiator group containing compound having an endocyclic double bond with a chalcogen atom in the allylic position of the initiator group and having at least two sites of unconjugated aliphatic unsaturation in the side chain substituent on the ring. The polyunsaturated compound is cyclized in the presence of a strong acid in a protic solvent which is inert to the acid, preferably a hydroxylic solvent. Mild temperatures and varying times are employed. The products are useful primarily as intermediates for naturally occurring and synthetic steroids. By appropriate substitution of the side chain, the steroidial products are provided with the substituent at C-11, which upon cyclization results in the alpha-configuration. By resolution of the intermediates prior to cyclization, optically active steroids can be obtained.
    Type: Grant
    Filed: June 23, 1977
    Date of Patent: December 12, 1978
    Assignee: The Board of Trustees of Leland Stanford Jr. University
    Inventors: Sina Escher, Grant E. Dubois
  • Patent number: 4055603
    Abstract: Polyenine compounds are provided having the naturally occurring geometry and a group which in the presence of acid initiates a carbocation cyclization to a steroid or A-nor-steroid structure, particularly the pregnane parent structure. The compounds are formed for the most part by condensation of two units prepared from readily available small molecules and are joined to form a polyenine, usully having a substituted carbocyclic ring which upon contact with a Lewis acid catalyst (includes protonic) cyclizes directly to provide the 5-membered D ring as well as substitution at the C-20 position.
    Type: Grant
    Filed: August 4, 1975
    Date of Patent: October 25, 1977
    Assignee: The Board of Trustees of Leland Stanford Junior University
    Inventors: William S. Johnson, Michael B. Gravestock