Oxy, Bonded Directly To A Ring, In Same Side Chain As Ester Function Patents (Class 560/61)
  • Patent number: 10442762
    Abstract: The subject of the invention is a novel process for the preparation of Carboprost tromethamine salt where alkylation the enone of the general formula (II) is carried out in the presence of a chiral auxiliary in aprotic solvent with a Grignard reagent. The methyl ester epimers of formula (VII) are separated by gravity silica gel chromatography and the salt formation is carried out by using solid tromethamine base.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: October 15, 2019
    Assignee: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA ZRT.
    Inventors: Péter Buzder-Lantos, Zsuzsanna Kardos, Irén Hortobágyi, István Lászlófi, Imre Juhász, László Fónagy, Csaba Váradi, Ágnes Nagyné Borkó
  • Patent number: 10166201
    Abstract: It discloses a compound of formula I that inhibits the activities of numerous of protein kinases involving the signaling of inflammatory cytokines, therefore, the compound can be used for treating cancers, autoimmune diseases and inflammatory diseases.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 1, 2019
    Assignee: RESOLVEX PHARMACEUTICALS INC.
    Inventors: Liren Tang, Junling Zhang, Tao Guo, Michael Patrick Allen Lyle
  • Patent number: 10098365
    Abstract: Provided are a freshness retaining agent that can be obtained by a simple method and exhibits excellent adsorption performance and antibacterial activity, a gas purification device including the freshness retaining agent, and a gas purification system. The freshness retaining agent is formed by adhering tea catechins to a surface and/or an inside of charcoal powders and adhering the charcoal powders to each other with clay interposed between the charcoal powders, thereby exhibiting excellent adsorption performance and antibacterial activity.
    Type: Grant
    Filed: December 10, 2014
    Date of Patent: October 16, 2018
    Assignee: TANKA CO., LTD.
    Inventor: Yasuo Irie
  • Patent number: 9221742
    Abstract: A caboxylic acid sulfonium salt having formula (1) is provided wherein R0 is hydrogen or a monovalent hydrocarbon group, R01 and R02 are hydrogen or a monovalent hydrocarbon group, at least one of R0, R01 and R02 has a cyclic structure, L is a single bond or forms an ester, sulfonate, carbonate or carbamate bond with the vicinal oxygen atom, R2, R3 and R4 are monovalent hydrocarbon groups. The sulfonium salt functions as a quencher in a resist composition, enabling to form a pattern of good profile with minimal LWR, rectangularity, and high resolution.
    Type: Grant
    Filed: September 9, 2014
    Date of Patent: December 29, 2015
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventors: Masaki Ohashi, Masahiro Fukushima, Tomohiro Kobayashi, Ryosuke Taniguchi
  • Publication number: 20150141479
    Abstract: The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II, and methods for treating or preventing or modulating moderate to severe pain in a disease may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.
    Type: Application
    Filed: February 4, 2013
    Publication date: May 21, 2015
    Inventor: Mahesh Kandula
  • Publication number: 20150133407
    Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of viscid or excessive mucus, cough, inflammation, redness in sore throat, infection in the throat, sore throat, abnormal mucus secretion, impaired mucus transport, allergic rhinitis, asthma, COPD, respiratory muscular disorders and pain in acute sore throat.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 14, 2015
    Inventor: Mahesh Kandula
  • Patent number: 8957240
    Abstract: The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method.
    Type: Grant
    Filed: July 29, 2013
    Date of Patent: February 17, 2015
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Robert R. Hogan, Ronald Rossi
  • Publication number: 20150045387
    Abstract: Bi- and tri-aromatic compounds of the formula (I) wherein R1 to RIO and X are as defined, are Nox2 inhibitors that are useful as medicaments for the treatment of a disease or condition selected from: cardiovascular diseases, respiratory diseases, inflammatory diseases, cancers, ageing and age related disorders, kidney diseases, neurodegenerative diseases, diabetes and conditions associated with diabetes. The compounds, their preparation and pharmaceutical compositions comprising them are disclosed.
    Type: Application
    Filed: September 17, 2012
    Publication date: February 12, 2015
    Inventors: Jian-Mei Li, Brendan Howlin, Daniel Nathan Meijles
  • Publication number: 20150013026
    Abstract: A new and distinct cultivar of Mentha spicata L. named KI-MsEM0110 and characterized by elevated levels of rosmarinic acid and vigorous growth.
    Type: Application
    Filed: February 7, 2012
    Publication date: January 8, 2015
    Applicant: KEMIN INDUSTRIES, INC.
    Inventors: John A. Greaves, Brindha Narasimhamoorthy, Sarah Wildgen, Rachel Barkely, Susan Ruden
  • Publication number: 20140309396
    Abstract: The invention is a polymerizable compound represented by formula (I); a polymerizable composition comprising the polymerizable compound and an initiator; a polymer obtained by polymerizing the polymerizable compound or the polymerizable composition, and an optically anisotropic article comprising the polymer. In the formula, Q1 to Q3 are a hydrogen atom, and the like; X is a C4-12 divalent aromatic group, and the like; Y1 to Y12 are a chemical single bond, —O—, —O—C(?O)—, —C(?O)—O—, and the like; G1 to G4 are a C1-20 divalent aliphatic group, and the like; Z1 to Z4 are a C2-10 alkenyl group, and the like; A1 is a trivalent aromatic group, and the like; A2 to A7 are a C4-30 divalent aromatic group, and the like; and n is 0 or 1.
    Type: Application
    Filed: June 14, 2012
    Publication date: October 16, 2014
    Applicant: ZEON CORPORATION
    Inventors: Kei Sakamoto, Kumi Okuyama
  • Publication number: 20140303395
    Abstract: The present invention relates to the use of oligohydroxybenzoic acid derivatives in washing and cleaning agents in order to improve washing or cleaning performance with respect to bleachable stains.
    Type: Application
    Filed: June 18, 2014
    Publication date: October 9, 2014
    Inventors: Christian Kropf, Mareile Job, Christian Umbreit, Siglinde Erpenbach
  • Patent number: 8846292
    Abstract: A radiation-sensitive composition containing a resist compound having a high sensitivity, a high resolution, a high etching resistance, and a low outgas which forms a resist pattern with good shape and a method of forming a resist pattern and novel compositions for forming a photoresist under coat film which is excellent in optical properties and etching resistance and contains substantially no sublimable substance and an under coat film formed by the composition. Radiation-sensitive composition containing a solvent and a cyclic compound having, e.g., a cyclic compound (A) having a molecular weight of 700 to 5000 which is synthesized by the condensation reaction of a compound having 2 to 59 carbon atoms and 1 to 4 formyl groups with a compound having 6 to 15 carbon atoms and 1 to 3 phenolic hydroxyl groups, and a cyclic compound for use in the radiation-sensitive composition.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: September 30, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Masatoshi Echigo, Dai Oguro
  • Publication number: 20140264168
    Abstract: The invention generally relates to optically variable devices, methods of preparation and applications or uses therefor. In particular, the invention includes trigger molecules employed as a dopant for a liquid crystal material. The liquid crystal material contains helical elements having a natural twist. The dopant is effective to change the natural twist of the helical elements when the dopant is addressed with incident light. Suitable dopants are selected from binaphthalene and derivatives thereof.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: OPSEC SECURITY GROUP, INC.
    Inventors: PAUL DUNN, ROBERT EDWARD RENTON, ANDREW NEIL CAMMIDGE
  • Publication number: 20140283199
    Abstract: Bio-regulators from a group of quaternary ammonium moieties modify a gene expression in undesirable plants to inhibit growth and robustness and enhance the effectiveness of herbicides. Such bio-regulator may be applied to plants through seed treatments, root drenching, spraying and dusting, or to soil were desirable crops are planted or will be planted. Bio-regulators may be duel-acting; causing beneficial modification to gene expressions in desirable plants while modifying gene expression in undesirable plants, making them more susceptible to herbicides. Bio-regulators are Ester Compounds, BMIA Compounds or related salts of those compounds.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 18, 2014
    Applicant: KamTec
    Inventor: KamTec
  • Publication number: 20140235857
    Abstract: The present invention pertains to a compound represented by a formula (I) and a method for producing thereof (in the formula, Ax is an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, Ay is a hydrogen atom, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group having 2 to 18 carbon atoms, an organic group having 2 to 30 carbon atoms that includes at least one aromatic ring selected from a group consisting of an aromatic hydrocarbon ring and an aromatic hetero ring, or the like. Ax and Ay optionally bond to each other to form a ring, and Q is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or the like.).
    Type: Application
    Filed: April 27, 2012
    Publication date: August 21, 2014
    Applicant: ZEON CORPORATION
    Inventors: Kei Sakamoto, Kumi Okuyama, Yasushi Nakano
  • Publication number: 20140228591
    Abstract: The invention relates to the use of a substituted, chiral amino alcohol, comprising one or more structural units of the following formula (1), wherein the abbreviations A, Y, R1 and R3 to R5 have the following meanings: is a covalent bond or a hydrocarbon group, Y is a covalent bond or a hydrocarbon group that can have an oxygen atom at one of its ends through which it is bonded to R1, R1 is an aliphatic or heterocyclic or aromatic radical, the carbon chain of which may be interrupted by one or more B groups, R5 is selected from the group consisting of (a) aliphatic radicals, wherein individual carbon atoms may be replaced by oxygen atoms or carbonyl groups, and wherein the carbon chains of same radicals may be optionally interrupted by a B group, and (b) araliphatic, cycloaliphatic, aromatic and heterocyclic radicals, wherein the carbon chain can be interrupted by one or more B structural elements and/or by one or more D coupling groups, R3, R4 are hydrogen or aliphatic or araliphatic substituents, which are
    Type: Application
    Filed: October 10, 2012
    Publication date: August 14, 2014
    Applicant: Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung E.V.
    Inventors: Monika Bauer, Lutz Hartmann, Frank Kuschel, Wolfgang Weissflog
  • Patent number: 8802147
    Abstract: The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: August 12, 2014
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20140213552
    Abstract: The present application provides novel compounds and methods for preparing and using these compounds. These compounds are useful in treating pain, itch, overactive bladder and/or interstitial cystitis in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) and a TRPV1 receptor activator. In one embodiment, the TRPV1 receptor activator is lidocaine.
    Type: Application
    Filed: March 20, 2014
    Publication date: July 31, 2014
    Applicant: Endo Pharmaceuticals Inc.
    Inventors: Scott Kevin Thompson, Roger Astbury Smith, Sandeep Gupta, Tony Priestley, Nicholas James Laping, Ashis K. Saha, Sonali Rudra
  • Publication number: 20140194604
    Abstract: The present invention is directed to methods for oxidizing internal olefins to ketones. In various embodiments, each method comprising contacting an organic substrate, having an initial internal olefin, with a mixture of (a) a biscationic palladium salt; and (b) an oxidizing agent; dissolved or dispersed in a solvent system to form a reaction mixture, said solvent system comprising at least one C2-6 carbon nitrile and optionally at least one secondary alkyl amide, said method conducted under conditions sufficient to convert at least 50 mol % of the initial internal olefin to a ketone, said ketone positioned on a carbon of the initial internal olefin. The transformation occurs at room temperature and shows wide substrate scope. Applications to the oxidation of seed oil derivatives and a bioactive natural product are described.
    Type: Application
    Filed: January 8, 2014
    Publication date: July 10, 2014
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Bill MORANDI, Robert H. GRUBBS, Zachary K. WICKENS
  • Patent number: 8765235
    Abstract: Provided is a novel polymerizable azomethine compound which has a high ?n and is colorless. The compound is represented by the formula (I). P1 and P2 each are a polymerizable group; m1 and m2 each are an integer of from 1 to 10; R1 and R2 each are an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, an alkoxycarbonyl group having from 2 to 5 carbon atoms, an acyloxy group having from 2 to 5 carbon atoms, an acyl group having from 2 to 4 carbon atoms, an amide group having from 2 to 5 carbon atoms, a cyano group or a halogen atom; n1 and n2 each are an integer of from 0 to 4; R3 is a hydrogen atom, or an alkyl group having from 1 to 4 carbon atoms; Z1 and L1 each are a predetermined divalent group; n is 0, 1 or 2.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: July 1, 2014
    Assignee: FUJIFILM Corporation
    Inventors: Masatoshi Mizumura, Shunya Katoh, Yasuhiro Ishiwata, Masaomi Kimura
  • Publication number: 20140154428
    Abstract: Provided is a liquid crystal alignment layer of which a constituent member is a compound represented by the general formula (I).
    Type: Application
    Filed: June 26, 2012
    Publication date: June 5, 2014
    Applicant: DIC CORPORATION
    Inventors: Martin Schadt, Sayaka Nose, Yutaka Nagashima, Isa Nishiyama, Haruyoshi Takatsu
  • Publication number: 20140107247
    Abstract: The invention provides a polymerizable compound represented by formula (I), a polymerizable composition, and a polymer that have a practical low melting point, can be produced at low cost, and can produce an optical film that achieves uniform conversion of polarized light over a wide wavelength band, and an optically anisotropic article.
    Type: Application
    Filed: April 12, 2012
    Publication date: April 17, 2014
    Applicant: ZEON CORPORATION
    Inventors: Kei Sakamoto, Kumi Okuyama
  • Publication number: 20140099370
    Abstract: The present invention relates to biodegradable polymers (e.g., polyesters and polyester amides) derived from functionalized biologically active compounds that can provide site specific delivery of bioactive compounds upon biodegradation in a controlled manner.
    Type: Application
    Filed: September 24, 2013
    Publication date: April 10, 2014
    Applicant: BEZWADA BIOMEDICAL, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20140080990
    Abstract: An object of the invention is to provide a polymerizable compound having small refractive index anisotropy and having high storage stability and high alignment properties when constituting a polymerizable liquid crystal composition, and provide a polymerizable liquid crystal composition containing the polymerizable compound. Further, the object is to provide a polymer produced by polymerizing the polymerizable liquid crystal composition and an optically anisotropic body including the polymer. The present invention provides a polymerizable compound represented by general formula (I), a polymerizable liquid crystal composition containing the compound as a constituent component, and further provides a polymer produced by polymerizing the polymerizable liquid crystal composition and an optically anisotropic body including the polymer.
    Type: Application
    Filed: April 5, 2012
    Publication date: March 20, 2014
    Applicant: DIC CORPORATION
    Inventors: Tetuo Kusumoto, Masahiro Horiguchi, Takashi Matsumoto, Yoshio Aoki, Masanao Hayashi, Masayuki Iwakubo
  • Patent number: 8633332
    Abstract: A method for isolating cimiracemate A from a Cimicifuga species is disclosed, comprising the steps of a) providing a sufficient quantity of raw materials from the Cimicifuga species, b) mixing the raw materials from the Cimicifuga species with an aqueous polar solvent at a temperature of about 20° C. to about 28° C. to obtain a solvent extract comprising cimiracemate A, and c) isolating cimiracemate A from the solvent extract.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: January 21, 2014
    Assignees: Purapharm Company Limited, Versitech Limited
    Inventors: Lai Hung Cindy Yang, Allan Sy Lau
  • Patent number: 8628685
    Abstract: Compounds including at least one mesogenic substructure and at least one long flexible segment and methods of synthesizing the same are disclosed. Formulations which include various embodiments of the mesogen-containing compounds and their use in articles of manufacture and ophthalmic devices are also disclosed.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: January 14, 2014
    Assignee: Transitions Optical, Inc
    Inventors: Meng He, Anil Kumar
  • Patent number: 8623238
    Abstract: The present invention relates to compounds represented by the following Formula Ic, in which R2-R6 can each independently be selected from hydrogen or hydrocarbyl (e.g., methyl); L1 and L4 are each independently a divalent linking group, such as a bond or —OC(O)—R8—C(O)O—, where R8 can be divalent hydrocarbyl (e.g., —CH2CH2—); each L2 and each L5 each independently represent a flexible segment, such as divalent linear or branched C1-C25 alkyl; each L3 and each L6 each independently represent a rigid segment including, for example, optionally substituted phenylen-1,4-diyl groups; t and s are each independently from 1 to 4; m and p are each independently from 0 to 4 for each t, provided that the sum of m and p is at least 1 for each t; q and r are each independently from 0 to 4 for each s, provided that the sum of q and r is at least 1 for each s; and E1 and E2 can each independently be hydrogen or hydrocarbyl.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: January 7, 2014
    Assignee: Transitions Optical, Inc.
    Inventors: Ruisong Xu, Xiao-Man Dai, Anil Kumar, Meng He, Chenguang Li, Rachael L. Yoest
  • Publication number: 20130345383
    Abstract: Branched and hyperbranched oligomers and polymers that contain a cashew nutshell oil or liquid component are provided. The novel oligomers and polymers are suitable for use as an oil, lubricant, coating, adhesive, resin or composite.
    Type: Application
    Filed: January 6, 2012
    Publication date: December 26, 2013
    Applicant: NDSU RESEARCH FOUNDATION
    Inventors: Zhigang Chen, Ren Liu
  • Patent number: 8614347
    Abstract: The present invention concerns the design of an environmentally friendly and efficient fluorous phase based on dendritic architectures containing short semifluorinated groups on their periphery.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: December 24, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Virgil Percec, Christopher J. Wilson, Daniela A. Wilson, Andrew E Feiring
  • Patent number: 8613868
    Abstract: The present invention relates to compounds represented by the following Formula I, In Formula I, R1 and R2 are each independently selected from hydrogen, and optionally substituted hydrocarbyl, provided that at least one of R1 and R2 is selected from optionally substituted hydrocarbyl (e.g., tertiary butyl); n is 0, 1 or 2, and each R3 is independently selected from optionally substituted hydrocarbyl; L1 is a divalent linking group, such as a bond or —C(O)O—; each L2 independently represents a flexible segment, such as divalent linear or branched C1-C25 alkyl; each L3 independently represents a rigid segment including, for example, optionally substituted phenylen-1,4-diyl groups; t is from 1 to 4; m and p are each independently from 0 to 4 for each t, provided that the sum of m and p is at least 1 for each t; and E can be, for example, C5-C18 aryl.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: December 24, 2013
    Assignee: Transitions Optical, Inc
    Inventors: Xiao-Man Dai, Ruisong Xu, Meng He, Anil Kumar, Rachael L. Yoest, Chenguang Li
  • Publication number: 20130316985
    Abstract: A pharmaceutical composition including at least one compound of the Formulas (I), (II), or (III), or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, as defined herein. Also disclosed is a method of treatment of diseases which are pathophysiologically related to GPR35, the GPR35-hERG signaling complex, or both, as defined herein.
    Type: Application
    Filed: May 20, 2013
    Publication date: November 28, 2013
    Applicant: Corning Incorporated
    Inventors: Huayun Deng, Ye Fang
  • Patent number: 8592621
    Abstract: A description is given of precursor compounds of sweet taste receptor antagonists for the prevention or treatment of disease, in particular for the prevention or treatment of Type 2 diabetes. A description is also given of uses of these precursor compounds and edible compositions, preparations for nutrition or pleasure or semi-finished products and pharmaceutical preparations, containing such precursor compounds.
    Type: Grant
    Filed: July 15, 2010
    Date of Patent: November 26, 2013
    Assignee: Symrise AG
    Inventors: Jakob Peter Ley, Michael Backes, Tobias Vössing, Frauke Stähler, Wolfgang Meyerhof, Christian Wintermeyer
  • Patent number: 8592131
    Abstract: An ortho-nitrobenzyl ester compound including a compound represented by Chemical Formula 1, and a positive photosensitive resin composition including the same are provided.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: November 26, 2013
    Assignee: Cheil Industries Inc.
    Inventors: Min-Kook Chung, Ji-Young Jeong, Hyun-Yong Cho, Yong-Sik Yoo, Jeong-Woo Lee, Jong-Hwa Lee, Hwan-Sung Cheon, Soo-Young Kim, Young-Ho Kim, Jae-Hyun Kim, Su-Min Park
  • Patent number: 8592622
    Abstract: A polymerizable fluorine-containing compound represented by formula (1), wherein R1 represents a polymerizable double-bond containing group, R2 represents an acid-labile protecting group, R3 represents a fluorine atom or fluorine-containing alkyl group, and W represents a bivalent linking group. This compound can provide a fluorine-containing polymer compound that has a weight-average molecular weight of 1,000-1,000,000 and contains a repeating unit represented by formula (2), wherein R2, R3 and W are defined as above, each of R4, R5 and R6 independently represents a hydrogen atom, fluorine atom or monovalent organic group, at least two of R4, R5 and R6 may be combined to form a ring. This polymer compound can provide a resist composition capable of forming a pattern that is transparent to exposure light and superior in rectangularity.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: November 26, 2013
    Assignee: Central Glass Company, Limited
    Inventors: Yoshimi Isono, Jonathan Joachim Jodry, Satoru Narizuka
  • Patent number: 8586607
    Abstract: There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type II diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: November 19, 2013
    Assignee: Syddansk Universitet
    Inventors: Trond Ulven, Elisabeth Christiansen
  • Patent number: 8580775
    Abstract: The present invention relates to substances which can be used as cosmetic ingredients, especially for skin whitening and as cosmetic agents against signs of ageing skin. The present invention also relates to the use of such substances for the manufacture of a medicament for the treatment of disorders related to the pigmentation of the skin. The invention furthermore relates to specific substances.
    Type: Grant
    Filed: February 26, 2008
    Date of Patent: November 12, 2013
    Assignee: Cognis IP Management GmbH
    Inventors: Thomas Markert, Philippe Moussou, Louis Danoux, Andreas Rathjens
  • Publication number: 20130281652
    Abstract: The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R?]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
    Type: Application
    Filed: October 17, 2012
    Publication date: October 24, 2013
    Inventor: Rao S. Bezwada
  • Patent number: 8541157
    Abstract: A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under the action of acid and an acid-generator component (B) which generates acid upon exposure, wherein the acid-generator component (B) includes an acid generator (B1) composed of a compound having a base dissociable group within a cation moiety.
    Type: Grant
    Filed: September 25, 2009
    Date of Patent: September 24, 2013
    Assignee: Tokyo Ohka Kogyo Co., Ltd.
    Inventors: Akiya Kawaue, Yoshiyuki Utsumi, Sho Abe
  • Patent number: 8519178
    Abstract: The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: August 27, 2013
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Robert R. Hogan, Ronald Rossi
  • Publication number: 20130204034
    Abstract: The present invention relates to an isolated, recombinant or synthetic polynucleotide encoding a polypeptide with protoilludene synthase activity and comprising a sequence selected from the group consisting of a) SEQ ID Nos. 1 or 14 of the attached sequence listing; b) a nucleic acid sequence complementary to SEQ ID Nos. 1 or 14; c) nucleic acid sequences which hybridize under stringent conditions to the nucleic acid sequences defined in a) and b) or their complementary strands, as well as to the polypeptide encoded by the isolated polynucleotide, as well as a method for the production of melleolides employing the polynucleotide or polypeptide of the invention.
    Type: Application
    Filed: January 31, 2013
    Publication date: August 8, 2013
    Applicant: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventor: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
  • Patent number: 8501037
    Abstract: Disclosed is a compound having high optical anisotropy and high compatibility with a polymer resin, which is represented by Formula 1 and has at least one substituent introduced to a biphenyl mesogenic core. Also, a resin composition including the compound and a polymer resin, and an optical member including the resin composition are disclosed. In the case of an optical member obtained by using a polymer resin composition including the compound represented by Formula 1, there is no phase separation, and it is possible to achieve a required optical characteristic with only a small amount thereof.
    Type: Grant
    Filed: August 19, 2008
    Date of Patent: August 6, 2013
    Assignee: LG Chem, Ltd.
    Inventors: Kiyoul Lee, Minjin Ko, Myungsun Moon, Jaeho Cheong, Bumgyu Choi, Daeho Kang, YunBong Kim
  • Patent number: 8487125
    Abstract: A method for producing caffeic acid phenyl ester and its analogues, which includes the steps of: (i) reacting, in a solvent, a salt of a compound of formula (II) with an organic halide having the formula X—R2-A2 in the presence of an iodide catalyst having the formula M-I to produce caffeic acid phenyl ester or its analogue, wherein A1, R1, Q, Y, X, R2, and M are defined herein; and (ii) isolating the caffeic acid phenyl ester or its analogue from the solvent.
    Type: Grant
    Filed: August 19, 2009
    Date of Patent: July 16, 2013
    Assignee: Chemigen
    Inventors: Junyi Liu, Yansheng Du
  • Patent number: 8481519
    Abstract: A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.
    Type: Grant
    Filed: January 28, 2006
    Date of Patent: July 9, 2013
    Assignee: LTS Lohmann Therapie-Systeme AG
    Inventors: Hans-Rainer Hoffmann, Rudolf Matusch, Aria Baniahmad
  • Publication number: 20130123453
    Abstract: Provided is a novel polymerizable azomethine compound which has a high ?n and is colorless. The compound is represented by the formula (I). P1 and P2 each are a polymerizable group; m1 and m2 each are an integer of from 1 to 10; R1 and R2 each are an alkyl group having from 1 to 4 carbon atoms, an alkoxy group having from 1 to 4 carbon atoms, an alkoxycarbonyl group having from 2 to 5 carbon atoms, an acyloxy group having from 2 to 5 carbon atoms, an acyl group having from 2 to 4 carbon atoms, an amide group having from 2 to 5 carbon atoms, a cyano group or a halogen atom; n1 and n2 each are an integer of from 0 to 4; R3 is a hydrogen atom, or an alkyl group having from 1 to 4 carbon atoms; Z1 and L1 each are a predetermined divalent group; n is 0, 1 or 2.
    Type: Application
    Filed: December 17, 2012
    Publication date: May 16, 2013
    Applicant: FUJIFILM Corporation
    Inventor: FUJIFILM Corporation
  • Publication number: 20130109825
    Abstract: A polymerizable composition containing a compound represented by the formula (I) or the formula (I?) is useful for formation of films having a high ?n with no coloration. P1 and P2 each are a polymerizable group; m1 and m2 each are an integer of from 1 to 10; A1 to A4 each are a predetermined cyclic group; R is a hydrogen atom or an alkyl; in the formula (I), Z1 is —COO—, —COO—, —OCO—CH?CH—, —NHCO— or —NR1CO—; L1 and L2 each are —O—, —S—, —COO—, —COO—, —OCO—CH?CH—, —OCOO—, —NHCO— or —NR1CO; n1 is 1 or 2; in the formula (I?), Z1 and Z2 each are —COO—, —OCO—, —NHCO— or NR1CO; L1 and L2 each are —O—, —S—, —COO—, —OCO—, —OCOO—, —NHCO— or NR1CO; n1 and n2 each are 1 or 2.
    Type: Application
    Filed: December 17, 2012
    Publication date: May 2, 2013
    Applicant: FUJIFILM CORPORATION
    Inventor: FUJIFILM Corporation
  • Patent number: 8431039
    Abstract: The present invention relates to compounds represented by the following Formula Ia, in which each R1-R6 can in each case be independently selected from hydrogen or hydrocarbyl (e.g., methyl); R7 is a multivalent linking group, such as L1 is a divalent linking group, such as a bond or divalent optionally substituted hydrocarbyl; each L2 independently represents a flexible segment, such as divalent linear or branched C1-C25 alkyl; each L3 independently represents a rigid segment including, for example, optionally substituted phenylen-1,4-diyl groups; t is from 1 to 4; m and p are each independently from 0 to 4 for each t, provided that the sum of m and p is at least 1 for each t; and E can be hydrogen or optionally substituted hydrocarbyl. The present invention also relates to compositions, such as liquid crystal compositions, and articles, such as optical elements, that include the compound represented by Formula Ia.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: April 30, 2013
    Assignee: Transitions Optical, Inc.
    Inventors: Xiao-Man Dai, Ruisong Xu, Meng He, Anil Kumar, Rachael L. Yoest, Chenguang Li
  • Patent number: 8399696
    Abstract: This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
    Type: Grant
    Filed: July 29, 2012
    Date of Patent: March 19, 2013
    Assignee: Bezwada Biomedical, LLC
    Inventor: Rao S Bezwada
  • Publication number: 20130030211
    Abstract: A bicyclohexane derivative compound useful in the field of photoresist, the field of intermediate of drugs and pesticides, and the like, and a manufacturing method of the same are provided. A bicyclohexane derivative compound represented by the following general formula (II) is provided. (In formula (II), Y independently represents an alkyl group of 1 to 10 carbons, a halogen atom, an acyloxy group, an alkoxycarbonyl group or a hydroxyl group, X1 represents a halogen atom, m represents an integer of 0 to 11, and m represents an integer of 0 to 10.
    Type: Application
    Filed: January 13, 2011
    Publication date: January 31, 2013
    Inventors: Masatoshi Echigo, Dai Oguro
  • Publication number: 20130012557
    Abstract: Small molecule choline kinase inhibitors, pharmaceutical compositions thereof, and screening methods for identifying and evaluating choline kinase inhibitors are provided. Safe and effective methods for treating subjects suffering from a disorder or disease characterized by neoplastic cell proliferation employing the choline kinase inhibitors are also provided.
    Type: Application
    Filed: May 12, 2012
    Publication date: January 10, 2013
    Applicant: UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC.
    Inventors: Brian Clem, Sucheta Telang, John Trent, Jason Chesney, Pooran Chand, Gilles Tapolsky
  • Patent number: 8349210
    Abstract: The present invention relates to compounds represented by the following Formula I, in which R1-R6 can each independently be selected from hydrogen or hydrocarbyl (e.g., methyl); L1 is a divalent linking group, such as a bond or —OC(O)—R8—C(O)O—, where R8 can be divalent hydrocarbyl (e.g., —CH2CH2—); each L2 independently represents a flexible segment, such as divalent linear or branched C1-C25 alkyl; each L3 independently represents a rigid segment including, for example, optionally substituted phenylen-1,4-diyl groups; t is from 1 to 4; m and p are each independently from 0 to 4 for each t, provided that the sum of m and p is at least 1 for each t; and E can be hydrogen or hydrocarbyl. The present invention also relates to compositions, such as liquid crystal compositions, and articles, such as optical elements, that include the compound represented by Formula I.
    Type: Grant
    Filed: August 8, 2011
    Date of Patent: January 8, 2013
    Assignee: Transitions Optical, Inc.
    Inventors: Ruisong Xu, Xiao-Man Dai, Anil Kumar, Meng He, Chenguang Li, Rachael L. Yoest