Halogen In Acid Moiety Patents (Class 560/62)
  • Patent number: 10226748
    Abstract: A reactor tank is provided having an enzyme inlet, a heating jacket positioned around the exterior center of the tank, a gas outlet communicating with a vacuum apparatus and a condensing unit, a first gas inlet for receiving gas from a feed tank and a first liquid outlet for recirculating the liquid back to the feed tank. The tank further includes a sparged unit connected to the first gas inlet for receiving gas from the feed tank and a screen positioned between the sparged unit and the first liquid outlet. The reactor tank is utilized in a reactor system further including a condensing unit, vacuum pump or venturi valve, a first feed tank, a coalescer having at least one circulation pipe and a first circulation pump.
    Type: Grant
    Filed: June 27, 2012
    Date of Patent: March 12, 2019
    Inventors: Rachel Burton, Greg Austic, Xiaohu Fan
  • Patent number: 9145356
    Abstract: A compound of formula (I) wherein Rf is —CF3, —C2F5, or —CF2CFXCF3; X is —F, or —OC3F7; Y is —H, —Cl, or —Br; R is —OH, —(OCH2CH2)mOH, —(CH2)n(OCH2CH2)mOH, —O—C(O)—R1, —(CH2)nO—C(O)R1, —(OCH2CH2)mOC(O)—R1, —C(O)NHw(CH2CH2OH)2-w, —C?N, —C?CH; n is 1 to 10; m is 1 to 10; R1 is C1 to C10 alkyl; a is 1 to 5; b is 1 to 5; and w is 0, 1 or 2.
    Type: Grant
    Filed: October 31, 2013
    Date of Patent: September 29, 2015
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: Neville Everton Drysdale
  • Publication number: 20150133654
    Abstract: The present invention provides methods and intermediates for the preparation of (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.
    Type: Application
    Filed: July 16, 2013
    Publication date: May 14, 2015
    Inventors: Albert J. DelMonte, Kenneth J. Natalie, JR., Kenneth J. Fraunhoffer, Christina Ann Risatti, Chao Hang, Zhinong Gao, Akin H. Davulcu, Wenhao Hu
  • Publication number: 20150011755
    Abstract: The present application relates to amine salts of prostaglandin analogs and their uses for the preparation of substantially pure prostaglandin analogs. Specific embodiments relate to amine salts of tafluprost and their uses for the preparation of substantially pure tafluprost.
    Type: Application
    Filed: February 6, 2013
    Publication date: January 8, 2015
    Applicant: DR. REDDYS LABORATORIES LIMITED
    Inventor: Mark P Jackson
  • Patent number: 8912356
    Abstract: The present application discloses a process for the preparation of a halofenate compound of the formula (III) or a salt thereof: wherein R, X and X? are as defined herein, the process comprising contacting a compound of formula (Ia) with a compound of formula (Ib) and N,N?-dicyclohexylcarbodiimide under conditions sufficient to form the compound of formula (III).
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: December 16, 2014
    Assignee: Cymabay Therapeutics, Inc.
    Inventor: Jiangao Song
  • Patent number: 8846292
    Abstract: A radiation-sensitive composition containing a resist compound having a high sensitivity, a high resolution, a high etching resistance, and a low outgas which forms a resist pattern with good shape and a method of forming a resist pattern and novel compositions for forming a photoresist under coat film which is excellent in optical properties and etching resistance and contains substantially no sublimable substance and an under coat film formed by the composition. Radiation-sensitive composition containing a solvent and a cyclic compound having, e.g., a cyclic compound (A) having a molecular weight of 700 to 5000 which is synthesized by the condensation reaction of a compound having 2 to 59 carbon atoms and 1 to 4 formyl groups with a compound having 6 to 15 carbon atoms and 1 to 3 phenolic hydroxyl groups, and a cyclic compound for use in the radiation-sensitive composition.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: September 30, 2014
    Assignee: Mitsubishi Gas Chemical Company, Inc.
    Inventors: Masatoshi Echigo, Dai Oguro
  • Publication number: 20140256549
    Abstract: The present invention relates to esters of carboxylic acid agrochemicals comprising a labile protecting group and having formula (I). Certain of the esters of carboxylic acid agrochemicals do not undergo hydrolysis to a significant degree in the dark, but are cleaved to regenerate the parent carboxylic acid agrochemical when exposed to light. Others of the esters of carboxylic acid agrochemicals undergo hydrolysis under both light and dark conditions. The present invention further relates to methods for the controlled release of a carboxylic acid agrochemicals, and to methods of controlling unwanted plants comprising applying to the unwanted plants an ester of a carboxylic acid agrochemical.
    Type: Application
    Filed: October 11, 2012
    Publication date: September 11, 2014
    Applicant: MONSANTO TECHNOLOGY LLC
    Inventor: David A. Morgenstern
  • Publication number: 20140206892
    Abstract: The present application discloses a process for the preparation of a halofenate compound of the formula (III) or a salt thereof: wherein R, X and X? are as defined herein, the process comprising contacting a compound of formula (Ia) with a compound of formula (Ib) and N,N?-dicyclohexylcarbodiimide under conditions sufficient to form the compound of formula (III).
    Type: Application
    Filed: January 18, 2013
    Publication date: July 24, 2014
    Applicant: Metabolex, Inc.
    Inventor: Metabolex, Inc.
  • Publication number: 20140051882
    Abstract: The present invention discloses a method of purification of prostaglandins including fluorine atoms by using preparative HPLC. Tafluprost and Travoprost are prostaglandins including fluorine. The chemical structure of the impurities in crude Tafluprost and crude Travoprost also contain fluorine, therefore, the removal of the impurities is difficult. Purification by using preparative high performance liquid chromatography (HPLC) can achieve high-quality liquid bulk drugs.
    Type: Application
    Filed: February 13, 2013
    Publication date: February 20, 2014
    Applicant: EVERLIGHT USA, INC.
    Inventors: Chia-Chung TSAI, Chien-Yuh CHEN, Sen-Bau LIANG, Yu-Chi LO, Chi-Hsiang YAO
  • Publication number: 20140024852
    Abstract: The present invention provides crystalline solid and amorphous forms of (?)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (?)-halofenate.
    Type: Application
    Filed: July 10, 2013
    Publication date: January 23, 2014
    Applicants: Diatex, Inc., Metabolex, Inc.
    Inventors: Edward D. Daugs, Eric J. Hagen, Jason A. Hanko, David H. Louks
  • Patent number: 8592622
    Abstract: A polymerizable fluorine-containing compound represented by formula (1), wherein R1 represents a polymerizable double-bond containing group, R2 represents an acid-labile protecting group, R3 represents a fluorine atom or fluorine-containing alkyl group, and W represents a bivalent linking group. This compound can provide a fluorine-containing polymer compound that has a weight-average molecular weight of 1,000-1,000,000 and contains a repeating unit represented by formula (2), wherein R2, R3 and W are defined as above, each of R4, R5 and R6 independently represents a hydrogen atom, fluorine atom or monovalent organic group, at least two of R4, R5 and R6 may be combined to form a ring. This polymer compound can provide a resist composition capable of forming a pattern that is transparent to exposure light and superior in rectangularity.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: November 26, 2013
    Assignee: Central Glass Company, Limited
    Inventors: Yoshimi Isono, Jonathan Joachim Jodry, Satoru Narizuka
  • Patent number: 8541614
    Abstract: The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: September 24, 2013
    Assignee: Metabolex, Inc.
    Inventors: Diego Broggini, Hartmut Burghard Zinser
  • Publication number: 20130004679
    Abstract: A diamine compound of formula (I) is proposed as well as polymers, copolymers, polyamic acids, polyamic acid esters, or polyimides based on such compound.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 3, 2013
    Applicant: ROLIC AG
    Inventors: Thomas BACHELS, Zoubair Mohammed CHERKAOUI, Guy MARCK, Olivier MULLER, Joachim REICHARDT, Andreas SCHUSTER, Hubert SEIBERLE, Peggy STUDER, Thomas PEGLOW, Jean-Francois ECKERT
  • Publication number: 20120232303
    Abstract: The present invention provides crystalline solid and amorphous forms of (?)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (?)-halofenate.
    Type: Application
    Filed: May 11, 2012
    Publication date: September 13, 2012
    Applicants: Diatex, Inc., Metabolex, Inc.
    Inventors: Edward D. Daugs, Eric J. Hagen, Jason A. Hanko, David H. Louks
  • Publication number: 20120232302
    Abstract: The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.
    Type: Application
    Filed: March 16, 2012
    Publication date: September 13, 2012
    Inventors: Diego BROGGINI, Hartmut Burghard Zinser
  • Publication number: 20120225940
    Abstract: The present invention provides the use of (?) (3-trihalomethylphenoxy) (4-halophenyl)acetic acid derivatives and compositions in the treatment of insulin resistance, Type 2 diabetes, hyperlipidemia and hyperuricemia.
    Type: Application
    Filed: March 28, 2012
    Publication date: September 6, 2012
    Inventors: Kenneth L. Luskey, Jian Luo
  • Publication number: 20120165566
    Abstract: The present invention is directed to novel macrocyclic compounds of formula (I) and their pharmaceutically acceptable salts, hydrates or solvates: wherein R1, R2, R3, R4, R5, R6 , n1, m, p Z1, Z2, and Z3 are as describe in the specification. The invention also relates to compounds of formula (I) which are antagonists of the motilin receptor and are useful in the treatment of disorders associated with this receptor and with or with motility dysfunction.
    Type: Application
    Filed: March 5, 2012
    Publication date: June 28, 2012
    Inventors: Eric Marsault, Luc Ouellet, Hamid R. Hoveyda
  • Patent number: 8203019
    Abstract: The present invention provides crystalline solid and amorphous forms of (?)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (?)-halofenate.
    Type: Grant
    Filed: April 20, 2006
    Date of Patent: June 19, 2012
    Assignees: Metabolex, Inc., DiaTex, Inc.
    Inventors: Edward D. Daugs, Eric J. Hagen, Jason A. Hanko, David H. Louks
  • Publication number: 20120070511
    Abstract: Compositions which modulate mitochondrial functions treat diseases associated with cells that are hyperactively using their endoplasmic reticulum. Screening assays identify agents which modulate mitochondrial functions.
    Type: Application
    Filed: September 21, 2011
    Publication date: March 22, 2012
    Applicant: UNIVERSITY OF MIAMI
    Inventors: Theodore Lampidis, Metin Kurtoglu
  • Patent number: 8101095
    Abstract: The racemic and chiral compounds expressed by common formula 1 and formula 2: wherein the lateral substituents X1, X2, X3, X4, X5, X6, X7 and X8 in the benzene rings represent independently hydrogen and fluorine atoms, bridge group Z represent independently the single bond or COO, CH2CH2, CH2O and OCH2 group, substituent Y represents CH3, or CH2F, CHF2, CF3, C2H5 group, symbols n, m, r and t are independently integers of 1 to 8; symbols p and s signify independently number of 0 to 1 and its orthoconic antiferroelectric long helical pitch mixtures prepared by the methods 1) to the racemic components selected from compounds 1 are added chiral components selected from the compound of formula 1 and/or chiral components selected from the compounds of formula 2 and/or another optically active compounds with high helical twisting power, 2) to chiral compound 1 which helical pitches increases with the temperature increase is added chiral compound 1 which helical pitch decreases with temperature increase.
    Type: Grant
    Filed: April 13, 2010
    Date of Patent: January 24, 2012
    Assignee: Wojskowa Akademia Techniczna IM. Jaroslawa Dabrowskiego
    Inventors: Roman Slawomir Dabrowski, Krzysztof Ludwik Czuprynski, Przemyslaw Kula, Magdalena Zurowska, Wojciech Rejmer, Wiktor Piecek, Zbigniew Raszewski
  • Publication number: 20110313170
    Abstract: This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. The reagents and methods provided herein may be used to access a broad range of compounds, including aromatic compounds, heteroaromatic compounds, amino acids, nucleotides, and synthetic compounds.
    Type: Application
    Filed: June 30, 2011
    Publication date: December 22, 2011
    Inventor: Stephen Gregory DiMagno
  • Publication number: 20110144293
    Abstract: The invention relates to compounds represented by Formula (1): wherein Ra is alkyl or the like; Rb is fluorine or —CF3; A is 1,4-cyclohexylene, 1,4-phenylene or the like; Z is a single bond, alkylene or the like; Y is a single bond, alkylene or the like; and m and n are an integer of approximately 0 to approximately 5.
    Type: Application
    Filed: February 23, 2011
    Publication date: June 16, 2011
    Applicants: CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATION
    Inventor: Takashi KATO
  • Publication number: 20110060116
    Abstract: New fluorinated ethers of aromatic acids and diesters are disclosed. These compositions can be applied to, e.g., fibers, yarns, carpets, garments, films, molded parts, paper and cardboard, stone, and tile to impart soil, water and oil resistance. By incorporating the fluorinated ethers of aromatic acids, or diesters thereof, into polymer backbones, more lasting soil, water and oil resistance, as well as improved flame retardance, can be achieved.
    Type: Application
    Filed: September 2, 2010
    Publication date: March 10, 2011
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Neville Everton Drysdale, Surbhi Mahajan Du, Kenneth Gene Moloy, Joel M. Pollino, Joachim C. Ritter
  • Publication number: 20100261772
    Abstract: The present invention relates to compounds of formula (I) with a variety of therapeutic uses, more particularly the substituted cyclic alkylidene compounds are useful for selective estrogen receptor modulation.
    Type: Application
    Filed: May 24, 2010
    Publication date: October 14, 2010
    Inventors: Jing Fang, Dennis Heyer, Subba Reddy Katamreddy, Kenneth William Batchelor, Richard Dana Caldwell
  • Publication number: 20100231844
    Abstract: A liquid crystal composition comprising at least one compound having a fluorobicyclo[2.2.2]octane skeleton represented by formula (I) below is disclosed. A fluorobicyclo[2.2.2]octane compound represented by formula (II) below is also disclosed. In the formulae, Y represents a hydrogen atom or fluorine atom.
    Type: Application
    Filed: March 11, 2010
    Publication date: September 16, 2010
    Applicant: FUJIFILM Corporation
    Inventors: Takashi Miyahara, Masayuki Harada
  • Patent number: 7737176
    Abstract: The invention relates to compounds of the formula I: and to the pharmaceutically acceptable salts thereof, to processes for the preparation of them and to pharmaceutical compositions comprising them, which are useful especially for the treatment and prevention of dyslipidaemia, atherosclerosis and diabetes.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: June 15, 2010
    Assignee: Merck Patent GmbH
    Inventors: Michel Brunet, Jean-Jacques Zeiller, Gérard Ferrand, Yves Bonhomme
  • Patent number: 7718656
    Abstract: Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: May 18, 2010
    Assignee: Nicox S.A.
    Inventors: Francesca Benedini, Valerio Chiroli, Wesley Kwan Mung Chong, Achim Hans-Peter Krauss, Michael Ross Niesman, Ennio Ongini
  • Patent number: 7618690
    Abstract: A liquid crystal compound represented by the formula CH2?CR1—COO-(L)k-E1-E2-E3-E4-R2 wherein R1: a hydrogen atom or a methyl group; R2: a C1-8 alkyl group; k: 0 or 1; L: —(CH2)pO— or —(CH2)q— (wherein each of p and q which are independent of each other, is an integer of from 2 to 8); E1: a 1,4-phenylene group; E2, E3, E4: each independently a 1,4-phenylene group or a trans-1,4-cyclohexylene group and at least one of E2 and E3 is a trans-1,4-cyclohexylene group, provided that the 1,4-phenylene group and trans-1,4-cyclohexylene group in E1 to E4, may be such that a hydrogen atom bonded to a carbon atom in each group may be substituted by a fluorine atom, a chlorine atom or a methyl group. To provide a novel liquid crystal compound for preparing an optical element which can exhibit a proper Rd value depending upon usable wavelength and application and which is excellent in durability against a blue laser beam.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: November 17, 2009
    Assignee: Asahi Glass Company, Limited
    Inventors: Hiromichi Nagayama, Yuriko Kaida, Kara Yoshida
  • Patent number: 7597942
    Abstract: The invention relates to a polymerisable liquid crystal (LC) material, to optically biaxial films prepared thereof, to novel polymerisable compounds used therein and to the use of the material and films in optical devices like compensators and LC displays (LCDs).
    Type: Grant
    Filed: August 10, 2005
    Date of Patent: October 6, 2009
    Assignee: Merck Patent GmbH
    Inventors: Alison Linda May, Peter (Fangyun) Hsu, Tara Perrett, Ashley Nathan Smith, Owain Llyr Parri
  • Patent number: 7569518
    Abstract: A pyridazine compound represented by formula (1): has an excellent plant disease controlling effect.
    Type: Grant
    Filed: May 27, 2005
    Date of Patent: August 4, 2009
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Hiroshi Morishita, Akio Manabe
  • Publication number: 20090105352
    Abstract: This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.
    Type: Application
    Filed: September 17, 2008
    Publication date: April 23, 2009
    Applicant: Bezwada Biomedical, LLC
    Inventor: Rao S. Bezwada
  • Publication number: 20090093650
    Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
    Type: Application
    Filed: October 7, 2008
    Publication date: April 9, 2009
    Applicant: Metabolex, Inc.
    Inventors: Peng Cheng, Jingyuan Ma, Xin Chen, Yan Zhu, Zuchun Zhao
  • Publication number: 20080311507
    Abstract: Disclosed is a fluorine-containing compound represented by formula (1), wherein R1 represents a polymerizable double-bond containing group, R2 represents an acid-labile protecting group, R3 represents a fluorine atom or fluorine-containing alkyl group, and W represents a bivalent linking group. This compound can provide a fluorine-containing polymer compound that has a weight-average molecular weight of 1,000-1,000,000 and contains a repeating unit represented by formula (2), wherein R2, R3 and W are defined as above, each of R4, R5 and R6 independently represents a hydrogen atom, fluorine atom or monovalent organic group, at least two of R4, R5 and R6 may be combined to form a ring. This polymer compound can provide a resist composition capable of forming a pattern that is transparent to exposure light and superior in rectangularity.
    Type: Application
    Filed: June 11, 2008
    Publication date: December 18, 2008
    Applicant: Central Glass Company, Limited
    Inventors: Yoshimi ISONO, Jonathan Joachim JODRY, Satoru NARIZUKA
  • Patent number: 7465752
    Abstract: Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.
    Type: Grant
    Filed: April 6, 2005
    Date of Patent: December 16, 2008
    Assignee: Merck Patent GmbH
    Inventors: Jean Jacques Zeiller, Hervè Dumas, Valérie Guyard-Dangremont, Isabelle Berard, Francis Contard, Daniel Guerrier, Gérard Ferrand, Yves Bonhomme
  • Patent number: 7432394
    Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
    Type: Grant
    Filed: September 20, 2006
    Date of Patent: October 7, 2008
    Assignee: Metabolex, Inc.
    Inventors: Peng Cheng, Jingyuan Ma, Xin Chen, Yan Zhu, Zuchun Zhao
  • Publication number: 20080221018
    Abstract: The present invention provides crystalline solid and amorphous forms of (?)-halofenate. The crystalline solid forms may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of conditions associated with blood lipid deposition in a mammal, particularly those diseases related to Type 2 diabetes and hyperlipidemia. The invention also relates to a method for preventing or treating Type 2 diabetes and hyperlipidemia in a mammal comprising the step of administering a therapeutically effective amount of crystalline solid and amorphous forms of (?)-halofenate.
    Type: Application
    Filed: April 20, 2006
    Publication date: September 11, 2008
    Applicant: METABOLEX, INC.
    Inventors: Edward D. Daugs, Eric J. Hagen, Jason A. Hanko, David H. Louks
  • Publication number: 20080143943
    Abstract: The invention relates to a polymerisable liquid crystal (LC) material, to optically biaxial films prepared thereof, to novel polymerisable compounds used therein and to the use of the material and films in optical devices like compensators and LC displays (LCDs).
    Type: Application
    Filed: August 10, 2005
    Publication date: June 19, 2008
    Inventors: Alison Linda May, Peter (Fangyun) Hsu, Tara Perrett, Ashley Smith, Owain Parri
  • Publication number: 20080058544
    Abstract: The present invention provides a novel organic semiconductor material that affords efficient charge transport, under a wider range of conditions, by increasing the temperature stability and expanding the temperature range of the organic semiconductor material. In an organic semiconductor material comprising a liquid crystalline compound having substituents on the periphery of a rigid plate-like central structure, the substituents have a fluorinated phenylene group, and columns in which the molecules of the compound are accumulated in a stack are aligned hexagonally.
    Type: Application
    Filed: June 28, 2007
    Publication date: March 6, 2008
    Applicants: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY, CHISSO CORPORATION, CHISSO PETROCHEMICAL CORPORATION
    Inventors: Yasuyuki Sasada, Yo Shimizu, Hirosato Monobe
  • Publication number: 20070299276
    Abstract: A one-step process for the preparation of fluoroalkoxystyrene by contacting fluorinated olefin with a solution of hydroxystyrene is disclosed.
    Type: Application
    Filed: June 22, 2006
    Publication date: December 27, 2007
    Inventor: Andrew Edward Feiring
  • Patent number: 7273946
    Abstract: Prostaglandin nitroderivatives having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.
    Type: Grant
    Filed: January 5, 2005
    Date of Patent: September 25, 2007
    Assignee: Nicox S.A.
    Inventors: Eninnio Ongini, Valerio Chiroli, Francesca Benedini, Piero Del Soldato
  • Patent number: 7199259
    Abstract: The present invention provides a method for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula (I): from its enantiomeric mixture, where R1 is alkyl or haloalkyl R7 is heteroalkyl and X is halide.
    Type: Grant
    Filed: September 4, 2003
    Date of Patent: April 3, 2007
    Assignee: Metabolex, Inc.
    Inventor: Edward D. Daugs
  • Patent number: 7070838
    Abstract: The present invention provides a compound represented by formula (1) defined in the specification and a liquid crystal composition comprising the compound. The invention further provides a polymer obtained by polymerization of compound or composition above, and further the present invention provides a film, an optical anisotropic material, A ¼ or ½ wavelength functional plate, an optical compensation element, an optical element and a liquid crystal display element employing the polymer.
    Type: Grant
    Filed: June 23, 2004
    Date of Patent: July 4, 2006
    Assignees: Chisso Petrochemical Corporation, Chisso Corporation
    Inventors: Yasuyuki Sasada, Motoki Yanai
  • Patent number: 6897333
    Abstract: A process for the preparation of fibrates of formula I in which R1 is a halogen atom, a 2,2-dichloro-cyclopropyl group, a (4-chlorophenyul)-hydroxymethyl group, a-4-chlorobenzoyl group or a 2-(4-chlorobenzamido)-ethyl group, and R2 is hydrogen or a C1-C4 alkyl group.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: May 24, 2005
    Assignee: Solchem Italiana S.p.A.
    Inventor: Giuseppe Guazzi
  • Patent number: 6869967
    Abstract: Novel compounds of the general formula (I), the use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds and methods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Proliferator-Activated Receptors (PPAR), in particular the PPAR? suptype.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: March 22, 2005
    Assignee: Novo Nordisk A/S
    Inventors: Lone Jeppesen, Paul Stanley Bury, John Patrick Mogensen, Ingrid Pettersson, Per Sauerberg
  • Patent number: 6864287
    Abstract: The present invention relates to the compounds of the general formula (I) and their salts and stereoisomers for the production of medicaments for the treatment of cardiovascular disorders.
    Type: Grant
    Filed: August 31, 2000
    Date of Patent: March 8, 2005
    Assignee: Bayer Aktiengesellschaft
    Inventors: Cristina Alonso-Alija, Markus Heil, Dietmar Flubacher, Paul Naab, Johannes-Peter Stasch, Frank Wunder, Klaus Dembowsky, Elisabeth Perzborn, Elke Stahl
  • Patent number: 6770775
    Abstract: A method of synthesizing highly optically enriched &agr;-halo-esters comprises reacting acid halides with a cinchona alkaloid catalyst and a base to form intermediate ketenes. The ketenes are reacted with electrophilic halogenating reagents to produce &agr;-halo-esters with high enantiomeric excess. The base can be an inorganic salt. The thus-formed &agr;-halo-esters have utility in synthesizing other optically-pure materials.
    Type: Grant
    Filed: May 18, 2001
    Date of Patent: August 3, 2004
    Inventor: Harald Wack
  • Patent number: 6759101
    Abstract: Compounds that are useful as components in liquid crystal compositions, particularly in ferroelectric liquid crystal compositions. Compounds of the invention are rod-like molecules with a mesogenic (generally linear) core to which an alkene tail and an alkyl or alkoxy tail with a perfluoroalkyl terminal portion are bonded. Compounds of the invention can contain a variety of one, two or three ring cores, wherein the rings maybe aromatic or alicyclic. Alkenes of the invention are useful as components to improve LC properties of mixtures, for example, to lower melting point of lower freezing point, of LC compositions.
    Type: Grant
    Filed: January 3, 2001
    Date of Patent: July 6, 2004
    Assignee: Displaytech, Inc.
    Inventors: Neil Gough, Rohini Vohra, Michael Wand, Kundalika More, William N. Thurmes
  • Publication number: 20040073058
    Abstract: A process for the preparation of fibrates of formula I 1
    Type: Application
    Filed: November 24, 2003
    Publication date: April 15, 2004
    Inventor: Giuseppe Guazzi
  • Patent number: 6555577
    Abstract: The present invention relates to compounds of the general formula (I) The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: April 29, 2003
    Assignee: Novo Nordisk A/S
    Inventors: John Patrick Mogensen, Per Sauerberg, Paul Stanley Bury, Lone Jeppesen, Ingrid Pettersson
  • Patent number: RE37947
    Abstract: Novel pharmaceutically/cosmetically-active aromatic polyenic compounds have the structural formula (I): and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic, respiratory, cardiovascular, bone and ophthalmological disorders, as well as for the treatment of mammalian skin and hair conditions/disorders.
    Type: Grant
    Filed: January 5, 2000
    Date of Patent: December 31, 2002
    Assignee: Centre International de Recherches Dermatologiques Galderma
    Inventors: Jean-Michel Bernardon, Phillippe Nedoncelle